# Clinical Trial Simulation

## Documentation for package ‘simtrial’ version 0.3.2

- DESCRIPTION file.
- User guides, package vignettes and other documentation.
- Package NEWS.

## Help Pages

counting_process | Process survival data into counting process format
cut_data_by_date | Cut a dataset for analysis at a specified date
cut_data_by_event | Cut a dataset for analysis at a specified event count
early_zero_weight | Zero early weight for weighted logrank tests
ex1_delayed_effect | Time-to-event data example 1 for non-proportional hazards working group
ex2_delayed_effect | Time-to-event data example 2 for non-proportional hazards working group
ex3_cure_with_ph | Time-to-event data example 3 for non-proportional hazards working group
ex4_belly | Time-to-event data example 4 for non-proportional hazards working group
ex5_widening | Time-to-event data example 5 for non-proportional hazards working group
ex6_crossing | Time-to-event data example 6 for non-proportional hazards working group
fh_weight | Fleming-Harrington weighted logrank tests
fit_pwexp | Piecewise exponential survival estimation
get_analysis_date | Get the analysis date under multiple conditions
get_cut_date_by_event | Get date at which an event count is reached
mb_delayed_effect | Simulated survival dataset with delayed treatment effect
mb_weight | Magirr and Burman modestly weighted logrank tests
pvalue_maxcombo | MaxCombo p-value
randomize_by_fixed_block | Permuted fixed block randomization
rpwexp | The piecewise exponential distribution
rpwexp_enroll | Generate piecewise exponential enrollment
sim_fixed_n | Simulation of fixed sample size design for time-to-event endpoint
sim_pw_surv | Simulate a stratified time-to-event outcome randomized trial
to_sim_pw_surv | Convert enrollment and failure rates from 'sim_fixed_n()' to 'sim_pw_surv()' format