Interpolation and extrapolation with awareness of doses occurring before, at the same time of, or after the requested interpolation time point must account for many interactions. To ensure clarity in the interpolation/extrapolation methods and the decisions made by the algorithm, each potential choice is listed below with its accompanying calculation method. The code used to generate the table is the same as the code within the function.
The method list below is described and sorted in order of how many scenarios the method is applied to in the list.
For each of the summary tables below, the column headers are as follows:
Copy the input concentration at the given time to the output.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
NA | NA | both | FALSE | NA | FALSE |
NA | NA | both | FALSE | NA | TRUE |
NA | NA | both | FALSE | both | FALSE |
NA | NA | both | FALSE | both | TRUE |
NA | NA | both | FALSE | conc | FALSE |
NA | NA | both | FALSE | conc | TRUE |
NA | NA | both | FALSE | dose | FALSE |
NA | NA | both | FALSE | dose | TRUE |
NA | NA | both | TRUE | NA | FALSE |
NA | NA | both | TRUE | both | FALSE |
NA | NA | both | TRUE | conc | FALSE |
NA | NA | both | TRUE | dose | FALSE |
NA | NA | conc | NA | NA | FALSE |
NA | NA | conc | NA | NA | TRUE |
NA | NA | conc | NA | both | FALSE |
NA | NA | conc | NA | both | TRUE |
NA | NA | conc | NA | conc | FALSE |
NA | NA | conc | NA | conc | TRUE |
NA | NA | conc | NA | dose | FALSE |
NA | NA | conc | NA | dose | TRUE |
both | FALSE | both | FALSE | NA | FALSE |
both | FALSE | both | FALSE | NA | TRUE |
both | FALSE | both | FALSE | both | FALSE |
both | FALSE | both | FALSE | both | TRUE |
both | FALSE | both | FALSE | conc | FALSE |
both | FALSE | both | FALSE | conc | TRUE |
both | FALSE | both | FALSE | dose | FALSE |
both | FALSE | both | FALSE | dose | TRUE |
both | FALSE | both | TRUE | NA | FALSE |
both | FALSE | both | TRUE | both | FALSE |
both | FALSE | both | TRUE | conc | FALSE |
both | FALSE | both | TRUE | dose | FALSE |
both | FALSE | conc | NA | NA | FALSE |
both | FALSE | conc | NA | NA | TRUE |
both | FALSE | conc | NA | both | FALSE |
both | FALSE | conc | NA | both | TRUE |
both | FALSE | conc | NA | conc | FALSE |
both | FALSE | conc | NA | conc | TRUE |
both | FALSE | conc | NA | dose | FALSE |
both | FALSE | conc | NA | dose | TRUE |
both | TRUE | both | FALSE | NA | FALSE |
both | TRUE | both | FALSE | NA | TRUE |
both | TRUE | both | FALSE | both | FALSE |
both | TRUE | both | FALSE | both | TRUE |
both | TRUE | both | FALSE | conc | FALSE |
both | TRUE | both | FALSE | conc | TRUE |
both | TRUE | both | FALSE | dose | FALSE |
both | TRUE | both | FALSE | dose | TRUE |
both | TRUE | both | TRUE | NA | FALSE |
both | TRUE | both | TRUE | both | FALSE |
both | TRUE | both | TRUE | conc | FALSE |
both | TRUE | both | TRUE | dose | FALSE |
both | TRUE | conc | NA | NA | FALSE |
both | TRUE | conc | NA | NA | TRUE |
both | TRUE | conc | NA | both | FALSE |
both | TRUE | conc | NA | both | TRUE |
both | TRUE | conc | NA | conc | FALSE |
both | TRUE | conc | NA | conc | TRUE |
both | TRUE | conc | NA | dose | FALSE |
both | TRUE | conc | NA | dose | TRUE |
conc | NA | both | FALSE | NA | FALSE |
conc | NA | both | FALSE | NA | TRUE |
conc | NA | both | FALSE | both | FALSE |
conc | NA | both | FALSE | both | TRUE |
conc | NA | both | FALSE | conc | FALSE |
conc | NA | both | FALSE | conc | TRUE |
conc | NA | both | FALSE | dose | FALSE |
conc | NA | both | FALSE | dose | TRUE |
conc | NA | both | TRUE | NA | FALSE |
conc | NA | both | TRUE | both | FALSE |
conc | NA | both | TRUE | conc | FALSE |
conc | NA | both | TRUE | dose | FALSE |
conc | NA | conc | NA | NA | FALSE |
conc | NA | conc | NA | NA | TRUE |
conc | NA | conc | NA | both | FALSE |
conc | NA | conc | NA | both | TRUE |
conc | NA | conc | NA | conc | FALSE |
conc | NA | conc | NA | conc | TRUE |
conc | NA | conc | NA | dose | FALSE |
conc | NA | conc | NA | dose | TRUE |
dose | FALSE | both | FALSE | NA | FALSE |
dose | FALSE | both | FALSE | NA | TRUE |
dose | FALSE | both | FALSE | both | FALSE |
dose | FALSE | both | FALSE | both | TRUE |
dose | FALSE | both | FALSE | conc | FALSE |
dose | FALSE | both | FALSE | conc | TRUE |
dose | FALSE | both | FALSE | dose | FALSE |
dose | FALSE | both | FALSE | dose | TRUE |
dose | FALSE | both | TRUE | NA | FALSE |
dose | FALSE | both | TRUE | both | FALSE |
dose | FALSE | both | TRUE | conc | FALSE |
dose | FALSE | both | TRUE | dose | FALSE |
dose | FALSE | conc | NA | NA | FALSE |
dose | FALSE | conc | NA | NA | TRUE |
dose | FALSE | conc | NA | both | FALSE |
dose | FALSE | conc | NA | both | TRUE |
dose | FALSE | conc | NA | conc | FALSE |
dose | FALSE | conc | NA | conc | TRUE |
dose | FALSE | conc | NA | dose | FALSE |
dose | FALSE | conc | NA | dose | TRUE |
dose | TRUE | both | FALSE | NA | FALSE |
dose | TRUE | both | FALSE | NA | TRUE |
dose | TRUE | both | FALSE | both | FALSE |
dose | TRUE | both | FALSE | both | TRUE |
dose | TRUE | both | FALSE | conc | FALSE |
dose | TRUE | both | FALSE | conc | TRUE |
dose | TRUE | both | FALSE | dose | FALSE |
dose | TRUE | both | FALSE | dose | TRUE |
dose | TRUE | both | TRUE | NA | FALSE |
dose | TRUE | both | TRUE | both | FALSE |
dose | TRUE | both | TRUE | conc | FALSE |
dose | TRUE | both | TRUE | dose | FALSE |
dose | TRUE | conc | NA | NA | FALSE |
dose | TRUE | conc | NA | NA | TRUE |
dose | TRUE | conc | NA | both | FALSE |
dose | TRUE | conc | NA | both | TRUE |
dose | TRUE | conc | NA | conc | FALSE |
dose | TRUE | conc | NA | conc | TRUE |
dose | TRUE | conc | NA | dose | FALSE |
dose | TRUE | conc | NA | dose | TRUE |
Two doses with no concentrations between them, return NA.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
both | FALSE | NA | NA | NA | FALSE |
both | FALSE | NA | NA | NA | TRUE |
both | FALSE | NA | NA | dose | FALSE |
both | FALSE | NA | NA | dose | TRUE |
both | FALSE | dose | FALSE | NA | FALSE |
both | FALSE | dose | FALSE | NA | TRUE |
both | FALSE | dose | FALSE | both | FALSE |
both | FALSE | dose | FALSE | both | TRUE |
both | FALSE | dose | FALSE | conc | FALSE |
both | FALSE | dose | FALSE | conc | TRUE |
both | FALSE | dose | FALSE | dose | FALSE |
both | FALSE | dose | FALSE | dose | TRUE |
both | FALSE | dose | TRUE | NA | FALSE |
both | FALSE | dose | TRUE | both | FALSE |
both | FALSE | dose | TRUE | conc | FALSE |
both | FALSE | dose | TRUE | dose | FALSE |
both | TRUE | dose | FALSE | NA | FALSE |
both | TRUE | dose | FALSE | NA | TRUE |
both | TRUE | dose | FALSE | both | FALSE |
both | TRUE | dose | FALSE | both | TRUE |
both | TRUE | dose | FALSE | conc | FALSE |
both | TRUE | dose | FALSE | conc | TRUE |
both | TRUE | dose | FALSE | dose | FALSE |
both | TRUE | dose | FALSE | dose | TRUE |
both | TRUE | dose | TRUE | NA | FALSE |
both | TRUE | dose | TRUE | both | FALSE |
both | TRUE | dose | TRUE | conc | FALSE |
both | TRUE | dose | TRUE | dose | FALSE |
dose | FALSE | NA | NA | NA | FALSE |
dose | FALSE | NA | NA | NA | TRUE |
dose | FALSE | NA | NA | both | FALSE |
dose | FALSE | NA | NA | both | TRUE |
dose | FALSE | NA | NA | dose | FALSE |
dose | FALSE | NA | NA | dose | TRUE |
dose | FALSE | dose | FALSE | NA | FALSE |
dose | FALSE | dose | FALSE | NA | TRUE |
dose | FALSE | dose | FALSE | both | FALSE |
dose | FALSE | dose | FALSE | both | TRUE |
dose | FALSE | dose | FALSE | conc | FALSE |
dose | FALSE | dose | FALSE | conc | TRUE |
dose | FALSE | dose | FALSE | dose | FALSE |
dose | FALSE | dose | FALSE | dose | TRUE |
dose | FALSE | dose | TRUE | NA | FALSE |
dose | FALSE | dose | TRUE | both | FALSE |
dose | FALSE | dose | TRUE | conc | FALSE |
dose | FALSE | dose | TRUE | dose | FALSE |
dose | TRUE | dose | FALSE | NA | FALSE |
dose | TRUE | dose | FALSE | NA | TRUE |
dose | TRUE | dose | FALSE | both | FALSE |
dose | TRUE | dose | FALSE | both | TRUE |
dose | TRUE | dose | FALSE | conc | FALSE |
dose | TRUE | dose | FALSE | conc | TRUE |
dose | TRUE | dose | FALSE | dose | FALSE |
dose | TRUE | dose | FALSE | dose | TRUE |
dose | TRUE | dose | TRUE | NA | FALSE |
dose | TRUE | dose | TRUE | both | FALSE |
dose | TRUE | dose | TRUE | conc | FALSE |
dose | TRUE | dose | TRUE | dose | FALSE |
Cannot calculate C0 without a concentration after an IV bolus; return NA.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
both | FALSE | both | TRUE | NA | TRUE |
both | FALSE | both | TRUE | both | TRUE |
both | FALSE | both | TRUE | dose | TRUE |
both | FALSE | dose | TRUE | NA | TRUE |
both | FALSE | dose | TRUE | both | TRUE |
both | FALSE | dose | TRUE | dose | TRUE |
both | TRUE | both | TRUE | NA | TRUE |
both | TRUE | both | TRUE | both | TRUE |
both | TRUE | both | TRUE | dose | TRUE |
both | TRUE | dose | TRUE | NA | TRUE |
both | TRUE | dose | TRUE | both | TRUE |
both | TRUE | dose | TRUE | dose | TRUE |
conc | NA | both | TRUE | NA | TRUE |
conc | NA | both | TRUE | both | TRUE |
conc | NA | both | TRUE | dose | TRUE |
conc | NA | dose | TRUE | NA | TRUE |
conc | NA | dose | TRUE | both | TRUE |
conc | NA | dose | TRUE | dose | TRUE |
dose | FALSE | both | TRUE | NA | TRUE |
dose | FALSE | both | TRUE | both | TRUE |
dose | FALSE | both | TRUE | dose | TRUE |
dose | FALSE | dose | TRUE | NA | TRUE |
dose | FALSE | dose | TRUE | both | TRUE |
dose | FALSE | dose | TRUE | dose | TRUE |
dose | TRUE | both | TRUE | NA | TRUE |
dose | TRUE | both | TRUE | both | TRUE |
dose | TRUE | both | TRUE | dose | TRUE |
dose | TRUE | dose | TRUE | NA | TRUE |
dose | TRUE | dose | TRUE | both | TRUE |
dose | TRUE | dose | TRUE | dose | TRUE |
Interpolation before any events is NA or zero (0) depending on the value of conc.origin. conc.origin defaults to zero which is the implicit assumption that a complete washout occurred and there is no endogenous source of the analyte.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
NA | NA | NA | NA | NA | FALSE |
NA | NA | NA | NA | NA | TRUE |
NA | NA | NA | NA | both | FALSE |
NA | NA | NA | NA | both | TRUE |
NA | NA | NA | NA | conc | FALSE |
NA | NA | NA | NA | conc | TRUE |
NA | NA | NA | NA | dose | FALSE |
NA | NA | NA | NA | dose | TRUE |
NA | NA | both | TRUE | NA | TRUE |
NA | NA | both | TRUE | both | TRUE |
NA | NA | both | TRUE | conc | TRUE |
NA | NA | both | TRUE | dose | TRUE |
NA | NA | dose | FALSE | NA | FALSE |
NA | NA | dose | FALSE | NA | TRUE |
NA | NA | dose | FALSE | both | FALSE |
NA | NA | dose | FALSE | both | TRUE |
NA | NA | dose | FALSE | conc | FALSE |
NA | NA | dose | FALSE | conc | TRUE |
NA | NA | dose | FALSE | dose | FALSE |
NA | NA | dose | FALSE | dose | TRUE |
NA | NA | dose | TRUE | NA | FALSE |
NA | NA | dose | TRUE | NA | TRUE |
NA | NA | dose | TRUE | both | FALSE |
NA | NA | dose | TRUE | both | TRUE |
NA | NA | dose | TRUE | conc | FALSE |
NA | NA | dose | TRUE | conc | TRUE |
NA | NA | dose | TRUE | dose | FALSE |
NA | NA | dose | TRUE | dose | TRUE |
Between an IV bolus and anything other than a concentration, interpolation cannot occur. Return NA
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
both | TRUE | NA | NA | NA | FALSE |
both | TRUE | NA | NA | NA | TRUE |
both | TRUE | NA | NA | both | FALSE |
both | TRUE | NA | NA | both | TRUE |
both | TRUE | NA | NA | dose | FALSE |
both | TRUE | NA | NA | dose | TRUE |
dose | TRUE | NA | NA | NA | FALSE |
dose | TRUE | NA | NA | NA | TRUE |
dose | TRUE | NA | NA | both | FALSE |
dose | TRUE | NA | NA | both | TRUE |
dose | TRUE | NA | NA | dose | FALSE |
dose | TRUE | NA | NA | dose | TRUE |
Extrapolate when the previous measurement is a concentration, and the current event is a dose or nothing. If the previous concentration measurement is below the limit of quantification (zero), then return zero.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
conc | NA | NA | NA | dose | FALSE |
conc | NA | NA | NA | dose | TRUE |
conc | NA | dose | FALSE | both | FALSE |
conc | NA | dose | FALSE | both | TRUE |
conc | NA | dose | FALSE | conc | FALSE |
conc | NA | dose | FALSE | conc | TRUE |
conc | NA | dose | FALSE | dose | FALSE |
conc | NA | dose | FALSE | dose | TRUE |
conc | NA | dose | TRUE | both | FALSE |
conc | NA | dose | TRUE | conc | FALSE |
conc | NA | dose | TRUE | dose | FALSE |
Calculate C0 for the time immediately after an IV bolus. First, attempt using log slope back-extrapolation. If that fails, use the first concentration after the dose as C0.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
both | FALSE | both | TRUE | conc | TRUE |
both | FALSE | dose | TRUE | conc | TRUE |
both | TRUE | both | TRUE | conc | TRUE |
both | TRUE | dose | TRUE | conc | TRUE |
conc | NA | both | TRUE | conc | TRUE |
conc | NA | dose | TRUE | conc | TRUE |
dose | FALSE | both | TRUE | conc | TRUE |
dose | FALSE | dose | TRUE | conc | TRUE |
dose | TRUE | both | TRUE | conc | TRUE |
dose | TRUE | dose | TRUE | conc | TRUE |
With concentrations before and after and not an IV bolus before, interpolate between observed concentrations.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
both | FALSE | NA | NA | both | FALSE |
both | FALSE | NA | NA | both | TRUE |
both | FALSE | NA | NA | conc | FALSE |
both | FALSE | NA | NA | conc | TRUE |
conc | NA | NA | NA | both | FALSE |
conc | NA | NA | NA | both | TRUE |
conc | NA | NA | NA | conc | FALSE |
conc | NA | NA | NA | conc | TRUE |
Extrapolate from the concentration data after the last dose.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
conc | NA | NA | NA | NA | FALSE |
conc | NA | NA | NA | NA | TRUE |
conc | NA | dose | FALSE | NA | FALSE |
conc | NA | dose | FALSE | NA | TRUE |
conc | NA | dose | TRUE | NA | FALSE |
First, calculate C0 using log slope back-extrapolation (falling back to the first post-dose concentration if that fails). Then, interpolate between C0 and the first post-dose concentration.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
both | TRUE | NA | NA | conc | FALSE |
both | TRUE | NA | NA | conc | TRUE |
dose | TRUE | NA | NA | conc | FALSE |
dose | TRUE | NA | NA | conc | TRUE |
If there is a non-IV bolus dose before, nothing at the current time, and a concentration after, extrapolate from prior data to the concentration at the time of dosing then interpolate between the dosing time and the requested output time.
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After |
---|---|---|---|---|---|
dose | FALSE | NA | NA | conc | FALSE |
dose | FALSE | NA | NA | conc | TRUE |
Event Before | IV Bolus Before | Event At | IV Bolus At | Event After | Instant After | Method Used |
---|---|---|---|---|---|---|
NA | NA | NA | NA | NA | FALSE | Before all events |
NA | NA | NA | NA | NA | TRUE | Before all events |
NA | NA | NA | NA | both | FALSE | Before all events |
NA | NA | NA | NA | both | TRUE | Before all events |
NA | NA | NA | NA | conc | FALSE | Before all events |
NA | NA | NA | NA | conc | TRUE | Before all events |
NA | NA | NA | NA | dose | FALSE | Before all events |
NA | NA | NA | NA | dose | TRUE | Before all events |
NA | NA | both | FALSE | NA | FALSE | Copy |
NA | NA | both | FALSE | NA | TRUE | Copy |
NA | NA | both | FALSE | both | FALSE | Copy |
NA | NA | both | FALSE | both | TRUE | Copy |
NA | NA | both | FALSE | conc | FALSE | Copy |
NA | NA | both | FALSE | conc | TRUE | Copy |
NA | NA | both | FALSE | dose | FALSE | Copy |
NA | NA | both | FALSE | dose | TRUE | Copy |
NA | NA | both | TRUE | NA | FALSE | Copy |
NA | NA | both | TRUE | NA | TRUE | Before all events |
NA | NA | both | TRUE | both | FALSE | Copy |
NA | NA | both | TRUE | both | TRUE | Before all events |
NA | NA | both | TRUE | conc | FALSE | Copy |
NA | NA | both | TRUE | conc | TRUE | Before all events |
NA | NA | both | TRUE | dose | FALSE | Copy |
NA | NA | both | TRUE | dose | TRUE | Before all events |
NA | NA | conc | NA | NA | FALSE | Copy |
NA | NA | conc | NA | NA | TRUE | Copy |
NA | NA | conc | NA | both | FALSE | Copy |
NA | NA | conc | NA | both | TRUE | Copy |
NA | NA | conc | NA | conc | FALSE | Copy |
NA | NA | conc | NA | conc | TRUE | Copy |
NA | NA | conc | NA | dose | FALSE | Copy |
NA | NA | conc | NA | dose | TRUE | Copy |
NA | NA | dose | FALSE | NA | FALSE | Before all events |
NA | NA | dose | FALSE | NA | TRUE | Before all events |
NA | NA | dose | FALSE | both | FALSE | Before all events |
NA | NA | dose | FALSE | both | TRUE | Before all events |
NA | NA | dose | FALSE | conc | FALSE | Before all events |
NA | NA | dose | FALSE | conc | TRUE | Before all events |
NA | NA | dose | FALSE | dose | FALSE | Before all events |
NA | NA | dose | FALSE | dose | TRUE | Before all events |
NA | NA | dose | TRUE | NA | FALSE | Before all events |
NA | NA | dose | TRUE | NA | TRUE | Before all events |
NA | NA | dose | TRUE | both | FALSE | Before all events |
NA | NA | dose | TRUE | both | TRUE | Before all events |
NA | NA | dose | TRUE | conc | FALSE | Before all events |
NA | NA | dose | TRUE | conc | TRUE | Before all events |
NA | NA | dose | TRUE | dose | FALSE | Before all events |
NA | NA | dose | TRUE | dose | TRUE | Before all events |
both | FALSE | NA | NA | NA | FALSE | Doses with no concentrations between |
both | FALSE | NA | NA | NA | TRUE | Doses with no concentrations between |
both | FALSE | NA | NA | both | FALSE | Interpolation |
both | FALSE | NA | NA | both | TRUE | Interpolation |
both | FALSE | NA | NA | conc | FALSE | Interpolation |
both | FALSE | NA | NA | conc | TRUE | Interpolation |
both | FALSE | NA | NA | dose | FALSE | Doses with no concentrations between |
both | FALSE | NA | NA | dose | TRUE | Doses with no concentrations between |
both | FALSE | both | FALSE | NA | FALSE | Copy |
both | FALSE | both | FALSE | NA | TRUE | Copy |
both | FALSE | both | FALSE | both | FALSE | Copy |
both | FALSE | both | FALSE | both | TRUE | Copy |
both | FALSE | both | FALSE | conc | FALSE | Copy |
both | FALSE | both | FALSE | conc | TRUE | Copy |
both | FALSE | both | FALSE | dose | FALSE | Copy |
both | FALSE | both | FALSE | dose | TRUE | Copy |
both | FALSE | both | TRUE | NA | FALSE | Copy |
both | FALSE | both | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
both | FALSE | both | TRUE | both | FALSE | Copy |
both | FALSE | both | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
both | FALSE | both | TRUE | conc | FALSE | Copy |
both | FALSE | both | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
both | FALSE | both | TRUE | dose | FALSE | Copy |
both | FALSE | both | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
both | FALSE | conc | NA | NA | FALSE | Copy |
both | FALSE | conc | NA | NA | TRUE | Copy |
both | FALSE | conc | NA | both | FALSE | Copy |
both | FALSE | conc | NA | both | TRUE | Copy |
both | FALSE | conc | NA | conc | FALSE | Copy |
both | FALSE | conc | NA | conc | TRUE | Copy |
both | FALSE | conc | NA | dose | FALSE | Copy |
both | FALSE | conc | NA | dose | TRUE | Copy |
both | FALSE | dose | FALSE | NA | FALSE | Doses with no concentrations between |
both | FALSE | dose | FALSE | NA | TRUE | Doses with no concentrations between |
both | FALSE | dose | FALSE | both | FALSE | Doses with no concentrations between |
both | FALSE | dose | FALSE | both | TRUE | Doses with no concentrations between |
both | FALSE | dose | FALSE | conc | FALSE | Doses with no concentrations between |
both | FALSE | dose | FALSE | conc | TRUE | Doses with no concentrations between |
both | FALSE | dose | FALSE | dose | FALSE | Doses with no concentrations between |
both | FALSE | dose | FALSE | dose | TRUE | Doses with no concentrations between |
both | FALSE | dose | TRUE | NA | FALSE | Doses with no concentrations between |
both | FALSE | dose | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
both | FALSE | dose | TRUE | both | FALSE | Doses with no concentrations between |
both | FALSE | dose | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
both | FALSE | dose | TRUE | conc | FALSE | Doses with no concentrations between |
both | FALSE | dose | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
both | FALSE | dose | TRUE | dose | FALSE | Doses with no concentrations between |
both | FALSE | dose | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
both | TRUE | NA | NA | NA | FALSE | After an IV bolus without a concentration next |
both | TRUE | NA | NA | NA | TRUE | After an IV bolus without a concentration next |
both | TRUE | NA | NA | both | FALSE | After an IV bolus without a concentration next |
both | TRUE | NA | NA | both | TRUE | After an IV bolus without a concentration next |
both | TRUE | NA | NA | conc | FALSE | After an IV bolus with a concentration next |
both | TRUE | NA | NA | conc | TRUE | After an IV bolus with a concentration next |
both | TRUE | NA | NA | dose | FALSE | After an IV bolus without a concentration next |
both | TRUE | NA | NA | dose | TRUE | After an IV bolus without a concentration next |
both | TRUE | both | FALSE | NA | FALSE | Copy |
both | TRUE | both | FALSE | NA | TRUE | Copy |
both | TRUE | both | FALSE | both | FALSE | Copy |
both | TRUE | both | FALSE | both | TRUE | Copy |
both | TRUE | both | FALSE | conc | FALSE | Copy |
both | TRUE | both | FALSE | conc | TRUE | Copy |
both | TRUE | both | FALSE | dose | FALSE | Copy |
both | TRUE | both | FALSE | dose | TRUE | Copy |
both | TRUE | both | TRUE | NA | FALSE | Copy |
both | TRUE | both | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
both | TRUE | both | TRUE | both | FALSE | Copy |
both | TRUE | both | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
both | TRUE | both | TRUE | conc | FALSE | Copy |
both | TRUE | both | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
both | TRUE | both | TRUE | dose | FALSE | Copy |
both | TRUE | both | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
both | TRUE | conc | NA | NA | FALSE | Copy |
both | TRUE | conc | NA | NA | TRUE | Copy |
both | TRUE | conc | NA | both | FALSE | Copy |
both | TRUE | conc | NA | both | TRUE | Copy |
both | TRUE | conc | NA | conc | FALSE | Copy |
both | TRUE | conc | NA | conc | TRUE | Copy |
both | TRUE | conc | NA | dose | FALSE | Copy |
both | TRUE | conc | NA | dose | TRUE | Copy |
both | TRUE | dose | FALSE | NA | FALSE | Doses with no concentrations between |
both | TRUE | dose | FALSE | NA | TRUE | Doses with no concentrations between |
both | TRUE | dose | FALSE | both | FALSE | Doses with no concentrations between |
both | TRUE | dose | FALSE | both | TRUE | Doses with no concentrations between |
both | TRUE | dose | FALSE | conc | FALSE | Doses with no concentrations between |
both | TRUE | dose | FALSE | conc | TRUE | Doses with no concentrations between |
both | TRUE | dose | FALSE | dose | FALSE | Doses with no concentrations between |
both | TRUE | dose | FALSE | dose | TRUE | Doses with no concentrations between |
both | TRUE | dose | TRUE | NA | FALSE | Doses with no concentrations between |
both | TRUE | dose | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
both | TRUE | dose | TRUE | both | FALSE | Doses with no concentrations between |
both | TRUE | dose | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
both | TRUE | dose | TRUE | conc | FALSE | Doses with no concentrations between |
both | TRUE | dose | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
both | TRUE | dose | TRUE | dose | FALSE | Doses with no concentrations between |
both | TRUE | dose | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
conc | NA | NA | NA | NA | FALSE | After all events, concentration before |
conc | NA | NA | NA | NA | TRUE | After all events, concentration before |
conc | NA | NA | NA | both | FALSE | Interpolation |
conc | NA | NA | NA | both | TRUE | Interpolation |
conc | NA | NA | NA | conc | FALSE | Interpolation |
conc | NA | NA | NA | conc | TRUE | Interpolation |
conc | NA | NA | NA | dose | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | NA | NA | dose | TRUE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | both | FALSE | NA | FALSE | Copy |
conc | NA | both | FALSE | NA | TRUE | Copy |
conc | NA | both | FALSE | both | FALSE | Copy |
conc | NA | both | FALSE | both | TRUE | Copy |
conc | NA | both | FALSE | conc | FALSE | Copy |
conc | NA | both | FALSE | conc | TRUE | Copy |
conc | NA | both | FALSE | dose | FALSE | Copy |
conc | NA | both | FALSE | dose | TRUE | Copy |
conc | NA | both | TRUE | NA | FALSE | Copy |
conc | NA | both | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
conc | NA | both | TRUE | both | FALSE | Copy |
conc | NA | both | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
conc | NA | both | TRUE | conc | FALSE | Copy |
conc | NA | both | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
conc | NA | both | TRUE | dose | FALSE | Copy |
conc | NA | both | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
conc | NA | conc | NA | NA | FALSE | Copy |
conc | NA | conc | NA | NA | TRUE | Copy |
conc | NA | conc | NA | both | FALSE | Copy |
conc | NA | conc | NA | both | TRUE | Copy |
conc | NA | conc | NA | conc | FALSE | Copy |
conc | NA | conc | NA | conc | TRUE | Copy |
conc | NA | conc | NA | dose | FALSE | Copy |
conc | NA | conc | NA | dose | TRUE | Copy |
conc | NA | dose | FALSE | NA | FALSE | After all events, concentration before |
conc | NA | dose | FALSE | NA | TRUE | After all events, concentration before |
conc | NA | dose | FALSE | both | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | FALSE | both | TRUE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | FALSE | conc | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | FALSE | conc | TRUE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | FALSE | dose | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | FALSE | dose | TRUE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | TRUE | NA | FALSE | After all events, concentration before |
conc | NA | dose | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
conc | NA | dose | TRUE | both | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
conc | NA | dose | TRUE | conc | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
conc | NA | dose | TRUE | dose | FALSE | Concentration, nothing or dose but not(dose, IV bolus, After), nothing or dose |
conc | NA | dose | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
dose | FALSE | NA | NA | NA | FALSE | Doses with no concentrations between |
dose | FALSE | NA | NA | NA | TRUE | Doses with no concentrations between |
dose | FALSE | NA | NA | both | FALSE | Doses with no concentrations between |
dose | FALSE | NA | NA | both | TRUE | Doses with no concentrations between |
dose | FALSE | NA | NA | conc | FALSE | After a dose with no event and a concentration after |
dose | FALSE | NA | NA | conc | TRUE | After a dose with no event and a concentration after |
dose | FALSE | NA | NA | dose | FALSE | Doses with no concentrations between |
dose | FALSE | NA | NA | dose | TRUE | Doses with no concentrations between |
dose | FALSE | both | FALSE | NA | FALSE | Copy |
dose | FALSE | both | FALSE | NA | TRUE | Copy |
dose | FALSE | both | FALSE | both | FALSE | Copy |
dose | FALSE | both | FALSE | both | TRUE | Copy |
dose | FALSE | both | FALSE | conc | FALSE | Copy |
dose | FALSE | both | FALSE | conc | TRUE | Copy |
dose | FALSE | both | FALSE | dose | FALSE | Copy |
dose | FALSE | both | FALSE | dose | TRUE | Copy |
dose | FALSE | both | TRUE | NA | FALSE | Copy |
dose | FALSE | both | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
dose | FALSE | both | TRUE | both | FALSE | Copy |
dose | FALSE | both | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
dose | FALSE | both | TRUE | conc | FALSE | Copy |
dose | FALSE | both | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
dose | FALSE | both | TRUE | dose | FALSE | Copy |
dose | FALSE | both | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
dose | FALSE | conc | NA | NA | FALSE | Copy |
dose | FALSE | conc | NA | NA | TRUE | Copy |
dose | FALSE | conc | NA | both | FALSE | Copy |
dose | FALSE | conc | NA | both | TRUE | Copy |
dose | FALSE | conc | NA | conc | FALSE | Copy |
dose | FALSE | conc | NA | conc | TRUE | Copy |
dose | FALSE | conc | NA | dose | FALSE | Copy |
dose | FALSE | conc | NA | dose | TRUE | Copy |
dose | FALSE | dose | FALSE | NA | FALSE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | NA | TRUE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | both | FALSE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | both | TRUE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | conc | FALSE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | conc | TRUE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | dose | FALSE | Doses with no concentrations between |
dose | FALSE | dose | FALSE | dose | TRUE | Doses with no concentrations between |
dose | FALSE | dose | TRUE | NA | FALSE | Doses with no concentrations between |
dose | FALSE | dose | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
dose | FALSE | dose | TRUE | both | FALSE | Doses with no concentrations between |
dose | FALSE | dose | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
dose | FALSE | dose | TRUE | conc | FALSE | Doses with no concentrations between |
dose | FALSE | dose | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
dose | FALSE | dose | TRUE | dose | FALSE | Doses with no concentrations between |
dose | FALSE | dose | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
dose | TRUE | NA | NA | NA | FALSE | After an IV bolus without a concentration next |
dose | TRUE | NA | NA | NA | TRUE | After an IV bolus without a concentration next |
dose | TRUE | NA | NA | both | FALSE | After an IV bolus without a concentration next |
dose | TRUE | NA | NA | both | TRUE | After an IV bolus without a concentration next |
dose | TRUE | NA | NA | conc | FALSE | After an IV bolus with a concentration next |
dose | TRUE | NA | NA | conc | TRUE | After an IV bolus with a concentration next |
dose | TRUE | NA | NA | dose | FALSE | After an IV bolus without a concentration next |
dose | TRUE | NA | NA | dose | TRUE | After an IV bolus without a concentration next |
dose | TRUE | both | FALSE | NA | FALSE | Copy |
dose | TRUE | both | FALSE | NA | TRUE | Copy |
dose | TRUE | both | FALSE | both | FALSE | Copy |
dose | TRUE | both | FALSE | both | TRUE | Copy |
dose | TRUE | both | FALSE | conc | FALSE | Copy |
dose | TRUE | both | FALSE | conc | TRUE | Copy |
dose | TRUE | both | FALSE | dose | FALSE | Copy |
dose | TRUE | both | FALSE | dose | TRUE | Copy |
dose | TRUE | both | TRUE | NA | FALSE | Copy |
dose | TRUE | both | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
dose | TRUE | both | TRUE | both | FALSE | Copy |
dose | TRUE | both | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
dose | TRUE | both | TRUE | conc | FALSE | Copy |
dose | TRUE | both | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
dose | TRUE | both | TRUE | dose | FALSE | Copy |
dose | TRUE | both | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |
dose | TRUE | conc | NA | NA | FALSE | Copy |
dose | TRUE | conc | NA | NA | TRUE | Copy |
dose | TRUE | conc | NA | both | FALSE | Copy |
dose | TRUE | conc | NA | both | TRUE | Copy |
dose | TRUE | conc | NA | conc | FALSE | Copy |
dose | TRUE | conc | NA | conc | TRUE | Copy |
dose | TRUE | conc | NA | dose | FALSE | Copy |
dose | TRUE | conc | NA | dose | TRUE | Copy |
dose | TRUE | dose | FALSE | NA | FALSE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | NA | TRUE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | both | FALSE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | both | TRUE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | conc | FALSE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | conc | TRUE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | dose | FALSE | Doses with no concentrations between |
dose | TRUE | dose | FALSE | dose | TRUE | Doses with no concentrations between |
dose | TRUE | dose | TRUE | NA | FALSE | Doses with no concentrations between |
dose | TRUE | dose | TRUE | NA | TRUE | Immediately after an IV bolus without a concentration next |
dose | TRUE | dose | TRUE | both | FALSE | Doses with no concentrations between |
dose | TRUE | dose | TRUE | both | TRUE | Immediately after an IV bolus without a concentration next |
dose | TRUE | dose | TRUE | conc | FALSE | Doses with no concentrations between |
dose | TRUE | dose | TRUE | conc | TRUE | Immediately after an IV bolus with a concentration next |
dose | TRUE | dose | TRUE | dose | FALSE | Doses with no concentrations between |
dose | TRUE | dose | TRUE | dose | TRUE | Immediately after an IV bolus without a concentration next |