The new QOI file format offers a very simple but efficient image compression algorithm. This package provides an easy and simple way to read, write and display bitmap images stored in the QOI (Quite Ok Image) format. It can read and write both files and in-memory raw vectors.

There are three functions: qol, miss_qol and miss_patient takes input of the data set containing the answers of QOL questionnaire. It will compute the three types of domain based scale scores: Global, Functional, and Symptoms. In case of missing data, the miss_qol and miss_patient functions will make the required changes and then calculate the domain-wise scale scores. Finally, provide an output replacing the question columns with the domain-based scale scores in the original data set.

Model fitting, optimal model selection and calculation of various features that are essential in the analysis of quantitative real-time polymerase chain reaction (qPCR).

Computes normalized cycle threshold (Ct) values (delta Ct) from raw quantitative polymerase 
    chain reaction (qPCR) Ct values and conducts test of significance using t.test(). Plots expression 
    values based from log2(2^(-1*delta delta Ct)) across groups per gene of interest. Methods for calculation
    of delta delta Ct and relative expression (2^(-1*delta delta Ct)) values are described in: 
    Livak & Schmittgen, (2001) <doi:10.1006/meth.2001.1262>.

Content-preserving transformations transformations of PDF files such 
    as split, combine, and compress. This package interfaces directly to the 'qpdf' 
    C++ API and does not require any command line utilities. Note that 'qpdf' does
    not read actual content from PDF files: to extract text and data you need the
    'pdftools' package.

Efficiently solve quadratic problems with linear inequality, equality and box constraints. The method used is outlined in D. Goldfarb, and A. Idnani (1983) <doi:10.1007/BF02591962>.

Computes noncompartmental pharmacokinetic parameters
 for drug concentration profiles.  For each profile, data
 imputations and adjustments are made as necessary and
 basic parameters are estimated. Supports single dose, multi-dose,
 and multi-subject data.  Supports steady-state calculations
 and various routes of drug administration. See ?qpNCA and vignettes.
 Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), 
 Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and
 Gibaldi and Perrier (1982, ISBN:978-0824710422).