Computes the optimal flow, Nash flow and the Price of Anarchy for any routing game defined within the game theoretical framework. The input is a routing game in the form of it’s cost and flow functions. Then transforms this into an optimisation problem, allowing both Nash and Optimal flows to be solved by nonlinear optimisation. See <https://en.wikipedia.org/wiki/Congestion_game> and Knight and Harper (2013) <doi:10.1016/j.ejor.2013.04.003> for more information.

Functions that interface with the 'Pocket' API (<https://getpocket.com/developer/>). Allows the user to get, add, and modify items in their own 'Pocket' account.

Penalized orthogonal-components regression (POCRE) is a supervised dimension reduction method for high-dimensional data. It sequentially constructs orthogonal components (with selected features) which are maximally correlated to the response residuals. POCRE can also construct common components for multiple responses and thus build up latent-variable models.

Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

This tool computes the probability of detection (POD) curve and the limit of detection (LOD), i.e. the number of copies of the target DNA sequence required to ensure a 95 % probability of detection (LOD95). Other quantiles of the LOD can be specified.
    This is a reimplementation of the mathematical-statistical modelling of the validation of qualitative polymerase chain reaction (PCR) methods within a single laboratory as provided by the commercial tool 'PROLab' <http://quodata.de/>. The modelling itself has been described by Uhlig et al. (2015) <doi:10.1007/s00769-015-1112-9>.