Provides an estimator for generalized linear models with incomplete
    data for discrete covariates. The estimation is based on the EM algorithm by the
    method of weights by Ibrahim (1990) <DOI:10.2307/2290013>.

Categorization and scoring of injury severity typically involves
    trained personnel with access to injured persons or their medical records. 'icdpicr' contains a function
    that provides automated calculation of Abbreviated Injury Scale ('AIS') and Injury Severity Score ('ISS')
    from International Classification of Diseases ('ICD') codes and may be a useful substitute to manual injury 
    severity scoring. 'ICDPIC' was originally developed in 'Stata', and 'icdpicr' is an open-access update 
    that accepts both 'ICD-9' and 'ICD-10' codes.

Identify Cancer Dysfunctional Sub-pathway by integrating gene expression, DNA methylation and copy number variation, and pathway topological information. 1)We firstly calculate the gene risk scores by integrating three kinds of data: DNA methylation, copy number variation, and gene expression.  2)Secondly, we perform a greedy search algorithm to identify the key dysfunctional sub-pathways within the pathways for which the discriminative scores were locally maximal. 3)Finally, the permutation test was used to calculate statistical significance level for these key dysfunctional sub-pathways.

Implements Individual Conditional Expectation (ICE) plots, a tool for visualizing the model estimated by any supervised learning algorithm. ICE plots refine Friedman's partial dependence plot by graphing the functional relationship between the predicted response and a covariate of interest for individual observations. Specifically, ICE plots highlight the variation in the fitted values across the range of a covariate of interest, suggesting where and to what extent they may exist.

Provides user-friendly and configurable print debugging via a
    single function, ic(). Wrap an expression in ic() to print the
    expression, its value and (where available) its source location.
    Debugging output can be toggled globally without modifying code.