A modular and computationally efficient R package for  
  parameterizing, simulating, and analyzing health economic simulation 
  models. The package supports cohort discrete time state transition models 
  (Briggs et al. 1998) <doi:10.2165/00019053-199813040-00003>,
  N-state partitioned survival models (Glasziou et al. 1990)
  <doi:10.1002/sim.4780091106>, and individual-level continuous 
  time state transition models (Siebert et al. 2012) <doi:10.1016/j.jval.2012.06.014>,
  encompassing both Markov (time-homogeneous and time-inhomogeneous) and 
  semi-Markov processes. Decision uncertainty from a cost-effectiveness analysis is 
  quantified with standard graphical and tabular summaries of a probabilistic 
  sensitivity analysis (Claxton et al. 2005, Barton et al. 2008) <doi:10.1002/hec.985>, 
  <doi:10.1111/j.1524-4733.2008.00358.x>. Use of C++ and data.table
  make individual-patient simulation, probabilistic sensitivity analysis, 
  and incorporation of patient heterogeneity fast.

Distribution free heteroscedastic tests for functional data. 
    The following tests are included in this package: test of no main treatment or contrast
    effect and no simple treatment effect given in 
    Wang, Higgins, and Blasi (2010) <doi:10.1016/j.spl.2009.11.016>,
    no main time effect, and no interaction effect based on 
    original observations given in Wang and Akritas (2010a) 
    <doi:10.1080/10485250903171621>
    and tests based on ranks given in Wang and Akritas (2010b)
    <doi:10.1016/j.jmva.2010.03.012>.

A comprehensive suite of spatial 
  functions created to analyze and assess data heterogeneity and climate variability 
  in spatial datasets. This package is specifically designed to address the challenges associated
  with characterizing and understanding complex spatial patterns in environmental and climate-related data.

The goal of this package is to user-friendly realizing Gaussian 
             graphical model-based heterogeneity analysis.
             Recently, several Gaussian graphical model-based heterogeneity 
             analysis techniques have been developed. A common methodological limitation 
             is that the number of subgroups is assumed to be known a priori, which 
             is not realistic. In a very recent study (Ren et al., 2022), a novel approach 
             based on the penalized fusion technique is developed to fully 
             data-dependently determine the number and structure of subgroups in 
             Gaussian graphical model-based heterogeneity analysis. It opens the door for utilizing 
             the Gaussian graphical model technique in more practical settings. Beyond 
             Ren et al. (2022), more estimations and functions are added, so 
             that the package is self-contained and more comprehensive and can 
             provide ``more direct'' insights to practitioners (with the 
             visualization function). Reference: 
             Ren, M., Zhang S., Zhang Q. and Ma S. (2022). Gaussian Graphical 
             Model-based Heterogeneity Analysis via Penalized Fusion. 
             Biometrics, 78 (2), 524-535.