PAM (Partitioning Around Medoids) algorithm application to samples of single cell sequencing techniques
	     with a high number of cells (as many as the computer memory allows). The package uses a binary format to
	     store matrices (either full, sparse or symmetric) in files written in the disk that can contain any data type
	     (not just double) which allows its manipulation when memory is sufficient to load them as int or float, but not
	     as double. The PAM implementation is done in parallel, using several/all the cores of the machine, if it has them.
	     This package shares a great part of its code with packages 'jmatrix' and 'parallelpam' but their functionality is
	     included here so there is no need to install them.

We introduce improved methods for statistically assessing birth seasonality and intra-annual variation. The first method we propose is a new idea that uses a nonparametric clustering procedure to group individuals with similar time series data and estimate birth seasonality based on the clusters. One can use the function SCEM() to implement this method. The second method estimates input parameters for use with a previously-developed parametric approach (Tornero et al., 2013). The relevant code for this approach is makeFits_OLS(), while makeFits_initial() is the code to implement the same method but with given initial conditions for two parameters. The latter can be used to show the disadvantage of the existing approach. One can use the function makeFits() to generate parametric birth seasonality estimates using either initialization. Detailed description can be found here: Chazin Hannah, Soudeep Deb, Joshua Falk, and Arun Srinivasan. (2019) "New Statistical Approaches to Intra-Individual Isotopic Analysis and Modeling Birth Seasonality in Studies of Herd Animals." <doi:10.1111/arcm.12432>.

Sometimes it is useful to serve up alternative 'shiny' UIs 
    depending on information passed in the request object, such as the value of 
    a cookie or a query parameter. This packages facilitates such switches.