Implements the Cross-contribution Compensating Multiple
    standard Normalization (CCMN) method described in Redestig et
    al. (2009) Analytical Chemistry <doi:10.1021/ac901143w>
    and other normalization algorithms.

Implements a wide range of model-based dose
    escalation designs, ranging from classical and modern continual
    reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
    dual-endpoint designs taking into account a biomarker/efficacy outcome. The
    focus is on Bayesian inference, making it very easy to setup a new design
    with its own JAGS code. However, it is also possible to implement 3+3
    designs for comparison or models with non-Bayesian estimation. The whole
    package is written in a modular form in the S4 class system, making it very
    flexible for adaptation to new models, escalation or stopping rules.

Method for fitting a cellwise robust linear M-regression model (CRM, Filzmoser et al. (2020) <DOI:10.1016/j.csda.2020.106944>) that yields both a map of cellwise outliers consistent with the linear model, and a vector of regression coefficients that is robust against vertical outliers and leverage points. As a by-product, the method yields an imputed data set that contains estimates of what the values in cellwise outliers would need to amount to if they had fit the model. The package also provides diagnostic tools for analyzing casewise and cellwise outliers using sparse directions of maximal outlyingness (SPADIMO, Debruyne et al. (2019) <DOI:10.1007/s11222-018-9831-5>).

Functions to help implement the extraction / subsetting / indexing
    function '[' and replacement function '[<-' of custom matrix-like types
    (based on S3, S4, etc.), modeled as closely to the base matrix class as
    possible (with tests to prove it).

A dashboard supports the usage of 'cromwell'. 
 'Cromwell' is a scientific workflow engine for command line users.
 This package utilizes 'cromwell' REST APIs and provides these convenient 
 functions: timing diagrams for running workflows, 'cromwell' engine status, 
 a tabular workflow list. For more information about 'cromwell', 
 visit <http://cromwell.readthedocs.io>.