Various utilities for the Multiplicative Multinomial distribution.

Gene Expression datasets for the 'MM2S' package. Contains normalized expression data for Human Medulloblastoma ('GSE37418') as well as Mouse Medulloblastoma models ('GSE36594'). Deena Gendoo et al. (2015) <doi:10.1016/j.ygeno.2015.05.002>.

The main function MMEst() performs (Restricted) Maximum Likelihood in a variance component mixed models using a Min-Max (MM) algorithm (Laporte, F., Charcosset, A. & Mary-Huard, T. (2022) <doi:10.1371/journal.pcbi.1009659>).

Used for general multiple mediation analysis. 
	The analysis method is described in Yu and Li (2022) (ISBN: 9780367365479) "Statistical Methods for Mediation, Confounding and Moderation Analysis Using R and SAS", published by Chapman and Hall/CRC; and Yu et al.(2017) <DOI:10.1016/j.sste.2017.02.001> "Exploring racial disparity in obesity: a mediation analysis considering geo-coded environmental factors", published on Spatial and Spatio-temporal Epidemiology, 21, 13-23.

Used for general multiple mediation analysis with big data sets.

Contains the data sets for the textbook "Mathematical Modeling and Applied Calculus" by Joel Kilty and Alex M. McAllister. The book will be published by Oxford University Press in 2018 with ISBN-13: 978-019882472.

The Minorize-Maximization(MM) algorithm based on Assembly-Decomposition(AD) technology can be used for model estimation of parametric models, semi-parametric models and non-parametric models. We selected parametric models including left truncated normal distribution, type I multivariate zero-inflated generalized poisson distribution and multivariate compound zero-inflated generalized poisson distribution; semiparametric models include Cox model and gamma frailty model; nonparametric model is estimated for type II interval-censored data. These general methods are proposed based on the following papers,
    Tian, Huang and Xu (2019) <doi:10.5705/SS.202016.0488>,
    Huang, Xu and Tian (2019) <doi:10.5705/ss.202016.0516>,
    Zhang and Huang (2022) <doi:10.1117/12.2642737>.