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Performs genomic mediation analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/078683>. It implements large scale mediation analysis and adaptively selects potential confounding variables to adjust for each mediation test from a pool of candidate confounders. The package is tailored for but not limited to genomic mediation analysis (e.g., cis-gene mediating trans-gene regulation pattern where an eQTL, its cis-linking gene transcript, and its trans-gene transcript play the roles as treatment, mediator and the outcome, respectively), restricting to scenarios with the presence of cis-association (i.e., treatment-mediator association) and random eQTL (i.e., treatment).
| Version: | 3.1 |
| Depends: | parallel |
| Published: | 2022-03-17 |
| Author: | Fan Yang, Jiebiao Wang and Lin Chen |
| Maintainer: | Jiebiao Wang <randel.wang at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL] |
| NeedsCompilation: | no |
| CRAN checks: | GMAC results |
| Reference manual: | GMAC.pdf |
| Package source: | GMAC_3.1.tar.gz |
| Windows binaries: | r-devel: GMAC_3.1.zip, r-release: GMAC_3.1.zip, r-oldrel: GMAC_3.1.zip |
| macOS binaries: | r-release (arm64): GMAC_3.1.tgz, r-oldrel (arm64): GMAC_3.1.tgz, r-release (x86_64): GMAC_3.1.tgz, r-oldrel (x86_64): GMAC_3.1.tgz |
| Old sources: | GMAC archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.