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MethScope identifies Most Recurrent Methylation Patterns (MRMPs) as the basis to encode latent representations for interpretatble analysis of DNA mehtylation data, in particular single cell and spatial methylome. The MRMPs embeddings will support automatic cell annotation, bulk deconvolution, unsupervisded clustering, and cancer cell of origin prediction.
Install the released version of usethis from CRAN:
install.packages("MethScope")or install from github
devtools::install_github("zhou-lab/MethScope")MethScope performs rapid cell annotation, deconvolution and other tasks for single cell and spatial DNA methylome. Please check out our documentation for more details:
If you use MethScope, kindly cite (coming soon):
Hongxiang Fu, Chin Nien Lee, Cameron Cloud, Hao Xu, Yanxiang Deng, Wanding Zhou, MethScope: Ultra-fast Analysis of Sparse DNA Methylome via Recurrent Pattern Encoding.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.