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OncoBayes2: Bayesian Logistic Regression for Oncology Dose-Escalation Trials

Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.

Version: 0.8-9
Depends: R (≥ 3.5.0)
Imports: methods, Rcpp (≥ 0.12.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.19.3), rstantools (≥ 2.3.1), posterior (≥ 1.4.0), assertthat (≥ 0.2.1), checkmate, Formula, bayesplot (≥ 1.4.0), ggplot2 (≥ 2.2.1), dplyr (≥ 0.8.0), tibble, tidyr (≥ 1.0.0), abind, scales, rlang (≥ 0.3.0), tidyselect, utils, stats, matrixStats
LinkingTo: BH (≥ 1.72.0), Rcpp (≥ 0.12.0), RcppEigen (≥ 0.3.3.3.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.19.3), StanHeaders (≥ 2.19.0)
Suggests: rmarkdown, knitr, testthat (≥ 2.0.0), mvtnorm, vdiffr, cmdstanr (≥ 0.4.0)
Published: 2023-07-20
DOI: 10.32614/CRAN.package.OncoBayes2
Author: Novartis Pharma AG [cph], Sebastian Weber [aut, cre], Lukas A. Widmer [aut], Andrew Bean [aut], Trustees of Columbia University [cph] (R/stanmodels.R, configure, configure.win)
Maintainer: Sebastian Weber <sebastian.weber at novartis.com>
License: GPL (≥ 3)
NeedsCompilation: yes
SystemRequirements: GNU make, pandoc (>= 1.12.3), pandoc-citeproc, C++17
Additional_repositories: https://mc-stan.org/r-packages/
Materials: NEWS
CRAN checks: OncoBayes2 results

Documentation:

Reference manual: OncoBayes2.pdf
Vignettes: Guiding Oncology Dose-Escalation Trials

Downloads:

Package source: OncoBayes2_0.8-9.tar.gz
Windows binaries: r-devel: OncoBayes2_0.8-9.zip, r-release: OncoBayes2_0.8-9.zip, r-oldrel: OncoBayes2_0.8-9.zip
macOS binaries: r-release (arm64): OncoBayes2_0.8-9.tgz, r-oldrel (arm64): OncoBayes2_0.8-9.tgz, r-release (x86_64): OncoBayes2_0.8-9.tgz, r-oldrel (x86_64): OncoBayes2_0.8-9.tgz
Old sources: OncoBayes2 archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=OncoBayes2 to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.