TxEffectsSurvival: Treatment Effect Inference for Terminal and Non-Terminal Events under Competing Risks

Provides several confidence interval and testing procedures, based on either semiparametric (using event-specific win ratios) or nonparametric measures, including the ratio of integrated cumulative hazard (RICH) and the ratio of integrated transformed cumulative hazard (RITCH), for treatment effect inference with terminal and non-terminal events under competing risks. The semiparametric results were developed in Yang et al. (2022 <doi:10.1002/sim.9266>), and the nonparametric results were developed in Yang (2025 <doi:10.1002/sim.70205>). For comparison, results for the win ratio (Finkelstein and Schoenfeld 1999 <doi:10.1002/(SICI)1097-0258(19990615)18:11%3C1341::AID-SIM129%3E3.0.CO;2-7>), Pocock et al. 2012 <doi:10.1093/eurheartj/ehr352>, and Bebu and Lachin 2016 <doi:10.1093/biostatistics/kxv032>) are included. The package also supports univariate survival analysis with a single event. In this package, effect size estimates and confidence intervals are obtained for each event type, and several testing procedures are implemented for the global null hypothesis of no treatment effect on either terminal or non-terminal events. Furthermore, a test of proportional hazards assumptions, under which the event-specific win ratios converge to hazard ratios, and a test of equal hazard ratios, are provided. For summarizing the treatment effect across all events, confidence intervals for linear combinations of the event-specific win ratios, RICH, or RITCH are available using pre-determined or data-driven weights. Asymptotic properties of these inference procedures are discussed in Yang et al. (2022 <doi:10.1002/sim.9266>) and Yang (2025 <doi:10.1002/sim.70205>).

Version:	1.0.2
Published:	2026-01-09
DOI:	10.32614/CRAN.package.TxEffectsSurvival
Author:	Daewoo Pak [aut, cre], Song Yang [aut]
Maintainer:	Daewoo Pak <dpak at yonsei.ac.kr>
License:	GPL (≥ 3)
NeedsCompilation:	no
Materials:	README, NEWS
CRAN checks:	TxEffectsSurvival results

Documentation:

Reference manual:

TxEffectsSurvival.html , TxEffectsSurvival.pdf

Downloads:

Package source:	TxEffectsSurvival_1.0.2.tar.gz
Windows binaries:	r-devel: TxEffectsSurvival_1.0.2.zip, r-release: TxEffectsSurvival_1.0.2.zip, r-oldrel: TxEffectsSurvival_1.0.2.zip
macOS binaries:	r-release (arm64): TxEffectsSurvival_1.0.2.tgz, r-oldrel (arm64): TxEffectsSurvival_1.0.2.tgz, r-release (x86_64): TxEffectsSurvival_1.0.2.tgz, r-oldrel (x86_64): TxEffectsSurvival_1.0.2.tgz

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