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combiroc: Selection and Ranking of Omics Biomarkers Combinations Made Easy

Provides functions and a workflow to easily and powerfully calculating specificity, sensitivity and ROC curves of biomarkers combinations. Allows to rank and select multi-markers signatures as well as to find the best performing sub-signatures, now also from single-cell RNA-seq datasets. The method used was first published as a Shiny app and described in Mazzara et al. (2017) <doi:10.1038/srep45477> and further described in Bombaci & Rossi (2019) <doi:10.1007/978-1-4939-9164-8_16>, and widely expanded as a package as presented in the bioRxiv pre print Ferrari et al. <doi:10.1101/2022.01.17.476603>.

Version: 0.3.4
Depends: R (≥ 3.5.0)
Imports: tidyr, dplyr, ggplot2, gtools, pROC, stringr, stats, utils, moments
Suggests: testthat (≥ 3.0.0), knitr, markdown, rmarkdown, httr, Seurat
Published: 2023-07-06
DOI: 10.32614/CRAN.package.combiroc
Author: Ivan Ferrari ORCID iD [aut], Riccardo L. Rossi ORCID iD [aut, cre], Saveria Mazzara ORCID iD [aut], Mauro Bombaci ORCID iD [ccp, ctb, dtc]
Maintainer: Riccardo L. Rossi <ric.rossi at gmail.com>
BugReports: https://github.com/ingmbioinfo/combiroc/issues
License: MIT + file LICENSE
URL: https://doi.org/10.1101/2022.01.17.476603, https://github.com/ingmbioinfo/combiroc
NeedsCompilation: no
Language: en-US
Materials: README NEWS
CRAN checks: combiroc results

Documentation:

Reference manual: combiroc.pdf
Vignettes: Quick guide to CombiROC
Single cell Combiroc tutorial

Downloads:

Package source: combiroc_0.3.4.tar.gz
Windows binaries: r-devel: combiroc_0.3.4.zip, r-release: combiroc_0.3.4.zip, r-oldrel: combiroc_0.3.4.zip
macOS binaries: r-release (arm64): combiroc_0.3.4.tgz, r-oldrel (arm64): combiroc_0.3.4.tgz, r-release (x86_64): combiroc_0.3.4.tgz, r-oldrel (x86_64): combiroc_0.3.4.tgz
Old sources: combiroc archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=combiroc to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.