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gsMeanFreq

Group sequential methods for composite endpoints based on mean frequency functions with recurrent and terminal events.

Description

The package implements simulation, estimation, and power calibration procedures for group sequential designs with composite endpoints, including recurrent events and terminal events. Both one-sample and two-sample settings are supported, with calendar-time monitoring.

Installation

install.packages("gsMeanFreq")

Example

This is a basic example which shows you how to solve a common problem:

library(gsMeanFreq)
# Simulate one-sample composite endpoint data
df <- Onesample.generate.sequential(
  size = 200,
  recruitment = 3,
  calendar = 5,
  random.censor.rate = 0.05,
  seed = 123
)
OneSample.Estimator.sequential(data= df, t = c(1.5, 2.9, 4.6))

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.