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presto: Fast Functions for Differential Expression Using Wilcoxon and AUC

Scalable implementation of the Wilcoxon rank sum test and the area under the receiver operating characteristic curve (also known as auROC or AUC) statistic. Interfaces to dense and sparse matrices, as well as the genomics analysis frameworks 'Seurat' and 'SingleCellExperiment'.

Version: 1.1.0
Depends: R (≥ 3.5.0)
Imports: Rcpp, data.table, dplyr, methods, tidyr, purrr, tibble, Matrix, rlang, stats, utils
LinkingTo: Rcpp, RcppArmadillo
Suggests: knitr, rmarkdown, testthat, Seurat, SingleCellExperiment, SummarizedExperiment, DelayedArray, broom, BiocStyle, DESeq2
Published: 2026-09-30
DOI: 10.32614/CRAN.package.presto
Author: Ilya Korsunsky ORCID iD [aut], Aparna Nathan [aut], Nghia Millard ORCID iD [aut], Soumya Raychaudhuri ORCID iD [aut], Kamil Slowikowski ORCID iD [cre, ctb], Austin Hartman ORCID iD [ctb]
Maintainer: Kamil Slowikowski <kslowikowski at gmail.com>
License: GPL-3
NeedsCompilation: yes
Materials: README, NEWS
CRAN checks: presto results

Documentation:

Reference manual: presto.html , presto.pdf
Vignettes: Getting started with presto (source)
Pseudobulk differential expression with DESeq2 (source)

Downloads:

Package source: presto_1.1.0.tar.gz
Windows binaries: r-devel: presto_1.1.0.zip, r-release: not available, r-oldrel: presto_1.1.0.zip
macOS binaries: r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): presto_1.1.0.tgz, r-oldrel (x86_64): presto_1.1.0.tgz

Reverse dependencies:

Reverse suggests: grandR, Seurat

Linking:

Please use the canonical form https://CRAN.R-project.org/package=presto to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.