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Final Report CTN-0094

CTN-0094 Team

2023-09-29

Table 1

Harmonized demographics data from the three National Drug Treatment Clinical Trials Network (CTN) opioid use disorder treatment trials (CTN-0027, CTN-0030, CTN-0051, , N= 2492)

27
(N=1269)
30
(N=653)
51
(N=570)
Overall
(N=2492)
Sex
Hispanic 206 (16.2%) 31 (4.7%) 99 (17.4%) 336 (13.5%)
Not Hispanic 1063 (83.8%) 622 (95.3%) 471 (82.6%) 2156 (86.5%)
Age
Mean (SD) 36.9 (11.1) 32.7 (10.2) 33.9 (9.63) 35.1 (10.7)
Median [Min, Max] 35.0 [18.0, 67.0] 30.0 [18.0, 77.0] 31.0 [19.0, 67.0] 33.0 [18.0, 77.0]
Ethnicity
Hispanic 206 (16.2%) 31 (4.7%) 99 (17.4%) 336 (13.5%)
Not Hispanic 1063 (83.8%) 622 (95.3%) 471 (82.6%) 2156 (86.5%)
Refused/Missing 0 (0%) 0 (0%) 0 (0%) 0 (0%)
Race
Refused/Missing 6 (0.5%) 1 (0.2%) 6 (1.1%) 13 (0.5%)
Black 128 (10.1%) 21 (3.2%) 73 (12.8%) 222 (8.9%)
Other 229 (18.0%) 35 (5.4%) 70 (12.3%) 334 (13.4%)
White 906 (71.4%) 596 (91.3%) 421 (73.9%) 1923 (77.2%)
Education
HS/GED 59 (4.6%) 253 (38.7%) 228 (40.0%) 540 (21.7%)
Less than HS 45 (3.5%) 102 (15.6%) 123 (21.6%) 270 (10.8%)
More than HS 59 (4.6%) 298 (45.6%) 219 (38.4%) 576 (23.1%)
Missing 1106 (87.2%) 0 (0%) 0 (0%) 1106 (44.4%)
Relationship Status
Married or Partnered 26 (2.0%) 186 (28.5%) 55 (9.6%) 267 (10.7%)
Never married 88 (6.9%) 326 (49.9%) 392 (68.8%) 806 (32.3%)
Separated/Divorced/Widowed 48 (3.8%) 139 (21.3%) 123 (21.6%) 310 (12.4%)
Missing 1107 (87.2%) 2 (0.3%) 0 (0%) 1109 (44.5%)
Employment
Full Time 69 (5.4%) 411 (62.9%) 268 (47.0%) 748 (30.0%)
Other 7 (0.6%) 16 (2.5%) 24 (4.2%) 47 (1.9%)
Part Time 34 (2.7%) 116 (17.8%) 116 (20.4%) 266 (10.7%)
Student 1 (0.1%) 28 (4.3%) 10 (1.8%) 39 (1.6%)
Unemployed 52 (4.1%) 82 (12.6%) 151 (26.5%) 285 (11.4%)
Missing 1106 (87.2%) 0 (0%) 1 (0.2%) 1107 (44.4%)
Usual Living Arragements
Stable 153 (12.1%) 651 (99.7%) 534 (93.7%) 1338 (53.7%)
Not Stable 9 (0.7%) 2 (0.3%) 36 (6.3%) 47 (1.9%)
Refused/Missing 1107 (87.2%) 0 (0%) 0 (0%) 1107 (44.4%)

Table 2

Harmonized Urine Drug Screen (UDS) data from the three National Drug Treatment Clinical Trials Network (CTN) opioid use disorder treatment trials

27
(N=26721)
30
(N=10364)
51
(N=10258)
Overall
(N=47343)
Substance
Amphetamine 1150 (4.3%) 254 (2.5%) 310 (3.0%) 1714 (3.6%)
Benzodiazepine 3089 (11.6%) 2049 (19.8%) 1116 (10.9%) 6254 (13.2%)
Cocaine 6595 (24.7%) 704 (6.8%) 800 (7.8%) 8099 (17.1%)
Methamphetamine 1462 (5.5%) 177 (1.7%) 308 (3.0%) 1947 (4.1%)
Opioid 8317 (31.1%) 1850 (17.9%) 1111 (10.8%) 11278 (23.8%)
Oxycodone 947 (3.5%) 2508 (24.2%) 151 (1.5%) 3606 (7.6%)
Propoxyphene 173 (0.6%) 164 (1.6%) 0 (0%) 337 (0.7%)
THC 4988 (18.7%) 2284 (22.0%) 1795 (17.5%) 9067 (19.2%)
Buprenorphine 0 (0%) 374 (3.6%) 4420 (43.1%) 4794 (10.1%)
Barbiturate 0 (0%) 0 (0%) 227 (2.2%) 227 (0.5%)
MDMA 0 (0%) 0 (0%) 20 (0.2%) 20 (0.0%)
27
(N=20961)
30
(N=6287)
51
(N=8638)
Overall
(N=35886)
Temperature In Range
No 25 (0.1%) 16 (0.3%) 40 (0.5%) 81 (0.2%)
Yes 20732 (98.9%) 6242 (99.3%) 8598 (99.5%) 35572 (99.1%)
Missing 204 (1.0%) 29 (0.5%) 0 (0%) 233 (0.6%)

Table 3

Medical and Psychiatric Co-Morbidities in the three National Drug Treatment Clinical Trials Network (CTN) opioid use disorder treatment trials

27
(N=1269)
30
(N=653)
51
(N=570)
Overall
(N=2492)
History of Schiziphrenia
Yes 32 (2.5%) 8 (1.2%) 7 (1.2%) 47 (1.9%)
No 1235 (97.3%) 645 (98.8%) 563 (98.8%) 2443 (98.0%)
Missing/Not Answered 2 (0.2%) 0 (0%) 0 (0%) 2 (0.1%)
History of Major Depression
Yes 352 (27.7%) 215 (32.9%) 179 (31.4%) 746 (29.9%)
No 917 (72.3%) 438 (67.1%) 391 (68.6%) 1746 (70.1%)
Missing/Not Answered 0 (0%) 0 (0%) 0 (0%) 0 (0%)
History of Bipolar Disorder
Yes 147 (11.6%) 37 (5.7%) 79 (13.9%) 263 (10.6%)
No 1121 (88.3%) 615 (94.2%) 491 (86.1%) 2227 (89.4%)
Missing/Not Answered 1 (0.1%) 1 (0.2%) 0 (0%) 2 (0.1%)
History of Anxiety/Panic Disorder
Yes 382 (30.1%) 204 (31.2%) 257 (45.1%) 843 (33.8%)
No 886 (69.8%) 448 (68.6%) 313 (54.9%) 1647 (66.1%)
Missing/Not Answered 1 (0.1%) 1 (0.2%) 0 (0%) 2 (0.1%)
History of Brain Damage
Yes 115 (9.1%) 119 (18.2%) 69 (12.1%) 303 (12.2%)
No 1151 (90.7%) 534 (81.8%) 501 (87.9%) 2186 (87.7%)
Missing/Not Answered 3 (0.2%) 0 (0%) 0 (0%) 3 (0.1%)
History of Epilepsy
Yes 40 (3.2%) 22 (3.4%) 49 (8.6%) 111 (4.5%)
No 1229 (96.8%) 631 (96.6%) 521 (91.4%) 2381 (95.5%)
Missing/Not Answered 0 (0%) 0 (0%) 0 (0%) 0 (0%)
DSM Opiate Diagnosis
Yes 1268 (99.9%) 653 (100%) 570 (100%) 2491 (100.0%)
No 1 (0.1%) 0 (0%) 0 (0%) 1 (0.0%)
Missing/Not Answered 0 (0%) 0 (0%) 0 (0%) 0 (0%)
DSM Alcohol Diagnosis
Yes 251 (19.8%) 0 (0%) 159 (27.9%) 410 (16.5%)
No 843 (66.4%) 0 (0%) 411 (72.1%) 1254 (50.3%)
Missing/Not Answered 175 (13.8%) 653 (100%) 0 (0%) 828 (33.2%)
DSM Amphetamine Diagnosis
Yes 120 (9.5%) 0 (0%) 106 (18.6%) 226 (9.1%)
No 974 (76.8%) 0 (0%) 464 (81.4%) 1438 (57.7%)
Missing/Not Answered 175 (13.8%) 653 (100%) 0 (0%) 828 (33.2%)
DSM Cannabis Diagnosis
Yes 223 (17.6%) 0 (0%) 163 (28.6%) 386 (15.5%)
No 871 (68.6%) 0 (0%) 407 (71.4%) 1278 (51.3%)
Missing/Not Answered 175 (13.8%) 653 (100%) 0 (0%) 828 (33.2%)
DSM Cocaine Diagnosis
Yes 357 (28.1%) 0 (0%) 175 (30.7%) 532 (21.3%)
No 737 (58.1%) 0 (0%) 394 (69.1%) 1131 (45.4%)
Missing/Not Answered 175 (13.8%) 653 (100%) 1 (0.2%) 829 (33.3%)
DSM Sedatives Diagnosis
Yes 153 (12.1%) 0 (0%) 153 (26.8%) 306 (12.3%)
No 941 (74.2%) 0 (0%) 417 (73.2%) 1358 (54.5%)
Missing/Not Answered 175 (13.8%) 653 (100%) 0 (0%) 828 (33.2%)
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