tsahr: Trial Sequential Analysis for Meta-Analyses of Hazard Ratios

Performs Trial Sequential Analysis (TSA) for meta-analyses of time-to-event outcomes reported as hazard ratios. Implements the Schoenfeld required-events sample-size formula generalised for unequal allocation, the Diversity (D-squared) heterogeneity adjustment of Wetterslev et al. (2009), and O'Brien-Fleming-type alpha- and beta-spending trial sequential monitoring boundaries computed at the inverse-variance information based on observed study-level log-HR standard errors (not merely event counts), via a compiled (C++) recursive numerical integration engine ported from the R package 'RTSA' (Soerensen, Olsen, Lange and Gluud; an R implementation of the Trial Sequential Analysis software of the Copenhagen Trial Unit, <https://ctu.dk/tools>), with no fixed software-imposed limit on the number of looks (subject to available computational resources). Produces a cumulative Z-curve plot with efficacy, futility, and conventional significance boundaries. Methodology follows Miladinovic et al. (2013) <doi:10.1016/j.jclinepi.2012.11.007> and Wetterslev et al. (2009) <doi:10.1186/1471-2288-9-86>.

Version:	0.2.8.17
Depends:	R (≥ 4.0.0)
Imports:	metafor, readxl, ggplot2 (≥ 3.4.0), stats, utils, Rcpp (≥ 1.0.0)
LinkingTo:	Rcpp
Suggests:	testthat (≥ 3.0.0), RTSA
Published:	2026-10-08
DOI:	10.32614/CRAN.package.tsahr (may not be active yet)
Author:	Tarak Dhaouadi [aut, cre], Anne Lyngholm Soerensen [ctb, cph] (author of the RTSA package, from which the boundary engine is ported), Markus Harboe Olsen [ctb, cph] (author of the RTSA package, from which the boundary engine is ported), Theis Lange [ctb, cph] (author of the RTSA package, from which the boundary engine is ported), Christian Gluud [ctb, cph] (author of the RTSA package, from which the boundary engine is ported)
Maintainer:	Tarak Dhaouadi <dhaouaditarak at yahoo.fr>
BugReports:	https://github.com/tarak-dhaouadi/tsahr/issues
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright:	inst/COPYRIGHTS tsahr copyright details
URL:	https://github.com/tarak-dhaouadi/tsahr
NeedsCompilation:	yes
Citation:	tsahr citation info
Materials:	README, NEWS
CRAN checks:	tsahr results

Documentation:

Reference manual:

tsahr.html , tsahr.pdf

Downloads:

Package source:	tsahr_0.2.8.17.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available

Linking:

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