Time to Event Outcome in Experimental Designs of Pre-Clinical Studies

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Documentation for package ‘PDXpower’ version 1.0.0

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mice1 Simulated preliminary mice uncensored data
mice2 Simulated preliminary mice censored data
plotpower A function to generate a four-panel power curve under specified number of PDX lines and number of individuals per PDX lines per treatment
PowANOVA A function to obtain a power table with the combination of various number of PDX lines and number of individuals per PDX lines per treatment based on a prior knowledge of median survival
PowANOVADat A function to obtain a power table with the combination of various number of PDX lines and number of individuals per PDX lines per treatment based on a preliminary dataset
PowerTable A function to obtain a power table with the combination of various number of PDX lines and number of individuals per PDX lines per treatment.
PowFrailty A function to obtain a power table with the combination of various number of PDX lines and number of individuals per PDX lines per treatment based on a prior knowledge of median survival
PowFrailtyDat A function to obtain a power table with the combination of various number of PDX lines and number of individuals per PDX lines per treatment based on a preliminary dataset
print.PowANOVADat Print PowANOVADat
print.PowerTable Print PowerTable
print.PowFrailtyDat Print PowFrailtyDat
SimPDXdata A function to calculate the power under pre-specified effect size, variance, and correlation using Monte Carlo sampling scheme by fitting ANOVA fixed effects model, ANOVA random effects model, Cox model, and frailty model.