Goldilocks Adaptive Trial Designs for Time-to-Event Endpoints

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Documentation for package ‘goldilocks’ version 0.3.0

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

enrollment	Simulate enrollment times
goldilocks	goldilocks
ppwe	Cumulative distribution function of the PWE for a vectorized hazard rate parameter
prop_to_haz	Estimate plausible piecewise constant hazard rates from summary summary event proportions
pwe_impute	Impute piecewise exponential time-to-event outcomes
pwe_sim	Simulate piecewise exponential time-to-event outcomes
randomization	Randomization allocation
sim_trials	Simulate one or more clinical trials subject to known design parameters and treatment effect
summarise_sims	Summarize simulations to get operating characteristics
survival_adapt	Simulate a single adaptive clinical trial with a time-to-event endpoint