Power and Sample Size Calculation for Non-Proportional Hazards

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Documentation for package ‘lrstat’ version 0.1.14

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

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lrstat-package	Power and Sample Size Calculation for Non-Proportional Hazards
accrual	Number of enrolled subjects
caltime	Calendar times for target number of events
errorSpent	Error spending functions
exitprob	Stagewise exit probabilities
fadjpbon	Adjusted p-values for Bonferroni-based graphical approaches
fadjpsim	Adjusted p-values for Simes-based graphical approaches
fseqbon	Group sequential trials using Bonferroni-based graphical approaches
fwgtmat	Weight matrix for all intersection hypotheses
getAccrualDuration	Accrual duration to enroll target number of subjects
getBound	Get efficacy boundaries for group sequential design
getDesign	Get group sequential design
getDurationFromNevents	Range of accrual duration for target number of events
getNeventsFromHazardRatio	Get the required number of events from hazard ratios
kmest	Stratified difference in milestone survival
lrpower	Log-rank test power
lrsamplesize	Log-rank test sample size
lrsim	Log-rank test simulation
lrsim2e	Log-rank test simulation for two endpoints and two arms
lrsim2e3a	Log-rank test simulation for two endpoints and three arms
lrsim3a	Log-rank test simulation for three arms
lrstat	Number of subjects having an event and log-rank statistics
qtpwexp	Quantile function of truncated piecewise exponential distribution
repeatedPValue	Repeated p-values for group sequential design
updateGraph	Update graph for graphical approaches