Clinical Trial Simulation

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Documentation for package ‘simtrial’ version 0.3.2

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

counting_process	Process survival data into counting process format
cut_data_by_date	Cut a dataset for analysis at a specified date
cut_data_by_event	Cut a dataset for analysis at a specified event count
early_zero_weight	Zero early weight for weighted logrank tests
ex1_delayed_effect	Time-to-event data example 1 for non-proportional hazards working group
ex2_delayed_effect	Time-to-event data example 2 for non-proportional hazards working group
ex3_cure_with_ph	Time-to-event data example 3 for non-proportional hazards working group
ex4_belly	Time-to-event data example 4 for non-proportional hazards working group
ex5_widening	Time-to-event data example 5 for non-proportional hazards working group
ex6_crossing	Time-to-event data example 6 for non-proportional hazards working group
fh_weight	Fleming-Harrington weighted logrank tests
fit_pwexp	Piecewise exponential survival estimation
get_analysis_date	Get the analysis date under multiple conditions
get_cut_date_by_event	Get date at which an event count is reached
mb_delayed_effect	Simulated survival dataset with delayed treatment effect
mb_weight	Magirr and Burman modestly weighted logrank tests
pvalue_maxcombo	MaxCombo p-value
randomize_by_fixed_block	Permuted fixed block randomization
rpwexp	The piecewise exponential distribution
rpwexp_enroll	Generate piecewise exponential enrollment
sim_fixed_n	Simulation of fixed sample size design for time-to-event endpoint
sim_pw_surv	Simulate a stratified time-to-event outcome randomized trial
to_sim_pw_surv	Convert enrollment and failure rates from 'sim_fixed_n()' to 'sim_pw_surv()' format