# Genome-Wide Robust Analysis for Biobank Data (GRAB)

## Documentation for package ‘GRAB’ version 0.2.4

- DESCRIPTION file
- Package README

## Help Pages

CCT | Cauchy Combination Test for p-value aggregation
getPairwiseIBD | Calculate Pairwise IBD (Identity By Descent)
getSparseGRM | Make a 'SparseGRMFile' for 'GRAB.NullModel'.
getTempFilesFullGRM | Make temporary files to be passed to function 'getSparseGRM'.
GRAB.getGenoInfo | Get allele frequency and missing rate information from genotype data
GRAB.makePlink | Convert genotype matrix to PLINK format files
GRAB.Marker | Perform single-marker association tests using a fitted null model
GRAB.NullModel | Top-level API for generating a null model object used by GRAB.Marker and GRAB.Region
GRAB.POLMM | Instruction of POLMM method
GRAB.POLMM.Region | Instruction of POLMM-GENE method
GRAB.ReadGeno | Read genotype data from multiple file formats
GRAB.Region | Perform region-based association tests
GRAB.SAGELD | SAGELD method in GRAB package
GRAB.SimubVec | Simulate random effects based on family structure
GRAB.SimuGMat | Simulate genotype data matrix for related and unrelated subjects
GRAB.SimuGMatFromGenoFile | Simulate genotype matrix from external genotype file
GRAB.SimuPheno | Simulate phenotypes from linear predictors
GRAB.SPACox | Instruction of SPACox method
GRAB.SPAGRM | Instruction of SPAGRM method
GRAB.SPAmix | Instruction of SPAmix method
GRAB.WtCoxG | Instruction of WtCoxG method
SAGELD.NullModel | Construct SAGELD/GALLOP null model from a mixed-effects fit
SPAGRM.NullModel | Fit SPAGRM null model from residuals and relatedness inputs