# Overview of Examples

This package contains a number of vignettes, each one walking through an example analysis. The table below gives an overview.

Many of these examples recreate analyses from the series of Technical Support Documents published by the NICE Decision Support Unit (Dias et al. 2011). The exceptions are atrial fibrillation (Cooper et al. 2009), white blood cell transfusion (Turner et al. 2012), social anxiety (Perren et al., in preparation; Mayo-Wilson et al. 2014), and plaque psoriasis multilevel network meta-regression (Phillippo et al. 2020, 2022).

Title | Outcome type | Likelihood | Link function | Notable features
--- | --- | --- | --- | ---
Blocker | Counts | Binomial | logit | Pairwise MA
Dietary fat | Rates | Poisson | log | Analysis of log rate ratios from rate data
Diabetes | Counts with time at risk | Binomial | cloglog | Analysis of log hazard ratios from count data with time at risk
Parkinson’s | Continuous | Normal | Identity | Analysis of arm-based data, contrast-based data, and a mixture of both
HTA plaque psoriasis | Ordered | Multinomial (ordered) | probit | Analysis of ordered categorical outcomes
Statins | Counts | Binomial | logit | Meta-regression with subgroups
BCG vaccine | Counts | Binomial | logit | Meta-regression with a continuous covariate, predictive distributions
Smoking cessation | Counts | Binomial | logit | Assessing inconsistency with unrelated mean effects and node-splitting models
Thrombolytics | Counts | Binomial | logit | Assessing inconsistency with unrelated mean effects and node-splitting models
Atrial fibrillation | Counts | Binomial | logit | Meta-regression with shared class interactions
WBC transfusion | Counts | Binomial | logit | Informative log-Normal prior on \(\tau^2\)
ML-NMR plaque psoriasis | Binary (IPD) and counts (AgD), and ordered categorical | Bernoulli (IPD) and two-parameter Binomial (AgD), and ordered multinomial | probit | Multilevel network meta-regression combining IPD and AgD
ML-NMR newly diagnosed multiple myeloma | Time-to-event with censoring | M-spline baseline hazard | log | Multilevel network meta-regression combining IPD and AgD
Social anxiety | Continuous | Normal | Identity | Model selection with class effects models

## References

Cooper, N. J., A. J. Sutton, D. Morris, A. E. Ades, and N. J. Welton. 2009. “Addressing Between-Study Heterogeneity and Inconsistency in Mixed Treatment Comparisons: Application to Stroke Prevention Treatments in Individuals with Non-Rheumatic Atrial Fibrillation.” Statistics in Medicine 28 (14): 1861–81. https://doi.org/10.1002/sim.3594.
Dias, S., N. J. Welton, A. J. Sutton, D. M. Caldwell, G. Lu, S. Reken, and A. E. Ades. 2011. “NICE DSU Technical Support Documents 1-7: Evidence Synthesis for Decision Making.” National Institute for Health and Care Excellence. https://www.sheffield.ac.uk/nice-dsu.
Mayo-Wilson, Evan, Sofia Dias, Ifigeneia Mavranezouli, Kayleigh Kew, David M Clark, AE Ades, and Stephen Pilling. 2014. “Psychological and Pharmacological Interventions for Social Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis.” The Lancet Psychiatry 1 (5): 368–76.
Perren, S. J., H. Pedder, N. J. Welton, and D. M. Phillippo. In preparation. “Network Meta-Analysis with Class Effects: A Practical Guide and Model Selection Algorithm.”
Phillippo, D. M., S. Dias, A. E. Ades, M. Belger, A. Brnabic, D. Saure, Y. Schymura, and N. J. Welton. 2022. “Validating the Assumptions of Population Adjustment: Application of Multilevel Network Meta-Regression to a Network of Treatments for Plaque Psoriasis.” Medical Decision Making. https://doi.org/10.1177/0272989X221117162.
Phillippo, D. M., S. Dias, A. E. Ades, M. Belger, A. Brnabic, A. Schacht, D. Saure, Z. Kadziola, and N. J. Welton. 2020. “Multilevel Network Meta-Regression for Population-Adjusted Treatment Comparisons.” Journal of the Royal Statistical Society: Series A (Statistics in Society) 183 (3): 1189–1210. https://doi.org/10.1111/rssa.12579.
Turner, R. M., J. Davey, M. J. Clarke, S. G. Thompson, and J. P. T. Higgins. 2012. “Predicting the Extent of Heterogeneity in Meta-Analysis, Using Empirical Data from the Cochrane Database of Systematic Reviews.” International Journal of Epidemiology 41 (3): 818–27. https://doi.org/10.1093/ije/dys041.