# Statistical Framework for in Vivo Drug Combination Studies

## Documentation for package ‘SynergyLMM’ version 1.1.0

- DESCRIPTION file.
- User guides, package vignettes and other documentation.
- Package NEWS.

## Help Pages

APrioriPwr | _A Priori_ Synergy Power Analysis Based on Variability and Drug Effect
CookDistance | Cook's distance for individual subjects
getRTV | Helper function to calculate the relative tumor volume from an imput data frame of tumor growth
grwth_data | Example Tumor Growth Data
lmmModel | Linear Mixed Effect Model for Tumor Growth
lmmModel_estimates | Get estimates from a linear mixed model of tumor growth data
lmmModel_estimates.explme | Get estimates from a linear mixed model of tumor growth data
lmmModel_estimates.gompertzlme | Get estimates from a linear mixed model of tumor growth data
lmmSynergy | Synergy calculation using linear-mixed and non-linear mixed-effect models
lmmSynergy.explme | Synergy calculation using linear-mixed and non-linear mixed-effect models
lmmSynergy.gompertzlme | Synergy calculation using linear-mixed and non-linear mixed-effect models
logLikSubjectDisplacements | Likelihood displacements for the model
ObsvsPred | Observed vs predicted values and performance of the model
plot_lmmModel | Plotting of tumor growth data from a fitted model
plot_lmmSynergy | Plotting synergy results
plot_ObsvsPred | Plots of Observed vs Predicted Values
plot_ranefDiagnostics | Plots for random effects diagnostics
plot_residDiagnostics | Plots for residuals diagnostics
plot_SynergyLMM | Plotting SynergyLMM results
PostHocPwr | Post hoc power calculation based on simulations of the synergy evaluation using LMM.
Pwr | Calculates power based on a model fit
Pwr.lme | Performs power calculations
PwrSampleSize | _A Priori_ Synergy Power Analysis Based on Sample Size
PwrTime | _A Priori_ Synergy Power Analysis Based on Time
ranefDiagnostics | Diagnostics of random effects of the linear mixed model
residDiagnostics | Diagnostics of residuals of the linear mixed model
simulateTumorGrowth | Helper function to simulate tumor growth data for a two-drug combination experiment.