Package: BBMBC
Title: Beta-Binomial Models for Vaccine-Specific Memory B Cell
        Frequency and Power Calculations
Version: 0.1.0
Authors@R: 
    person("Andrew", "Shin", , "ashin2@uw.edu", role = c("aut", "cre"))
Description: Provides tools to model overdispersed vaccine-specific memory B cell frequencies using 
    Beta-Binomial generalized linear models, specifically designed for 
    analyzing vaccine-induced cellular immune responses. Includes 
    method-of-moments dispersion estimation, likelihood ratio testing 
    across experimental arms, and Monte Carlo simulation frameworks to 
    calculate statistical power and Type I error rates. The methodologies 
    are directly motivated by the analysis of immunology data in 
    'Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers 
    elicited tier 2 neutralizing antibodies in a phase 1 clinical trial' 
    (Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.
Encoding: UTF-8
Depends: R (>= 4.1.0)
Imports: doParallel, foreach, glmmTMB, parallel, stats, utils
Suggests: testthat (>= 3.0.0)
Config/testthat/edition: 3
Config/roxygen2/version: 8.0.0
License: MIT + file LICENSE
NeedsCompilation: no
Packaged: 2026-09-26 17:13:47 UTC; andrewshin
Author: Andrew Shin [aut, cre]
Maintainer: Andrew Shin <ashin2@uw.edu>
Repository: CRAN
Date/Publication: 2026-10-07 08:10:20 UTC
