Metric >=75kg patients
N = 97
1
<75kg patients
N = 103
1
Day 1
AUC (ng/mL*h) 122 (98–154) 144 (120–174)
Cmax (ng/mL) 10.17 (7.47–12.80) 10.26 (8.23–13.42)
tmax (h) 2.00 (1.00–6.00) 2.00 (1.00–6.00)
Ctrough (ng/mL) 2.24 (1.25–3.90) 3.46 (2.20–4.60)
Day 7
AUC (ng/mL*h) 168 (121–236) 233 (164–305)
Cmax (ng/mL) 13.4 (9.9–18.4) 16.4 (12.6–21.1)
tmax (h) 2.00 (1.00–6.00) 2.00 (1.00–6.00)
Ctrough (ng/mL) 3.23 (1.27–5.85) 5.95 (3.03–9.21)
1 Median (5% Centile–95% Centile)