<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Discovery of Candidate Disease Genes Using Trans-Regulatory
Effects</dc:title>
  <dc:title>R package DANDELION version 0.1.0</dc:title>
  <dc:description>Implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) &lt;doi:10.1080/01621459.2021.1914634&gt;. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Imports: igraph</dc:relation>
  <dc:relation>Suggests: qvalue</dc:relation>
  <dc:creator>Peixin Tian &lt;pxtian@connect.hku.hk&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Peixin Tian [aut, cre]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-05-04</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=DANDELION</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.DANDELION</dc:identifier>
</oai_dc:dc>
