A Logistic Regression Model for Testing Microbial Differential Abundance R package LOCOM2 version 1.0 Testing differential abundance at individual taxa and in a whole microbial community. The tests are based on the log-ratio of relative abundances. The tests accommodate continuous, discrete (binary, categorical), and multivariate traits, and allow adjustment of confounders. For more details see He (2026) <doi:10.64898/2026.04.07.716976>. Software Depends: R (>= 3.5.0) Imports: Rcpp (>= 1.0.11), stats, permute, parallel, BiocParallel, matrixStats, abind, car LinkingTo: Rcpp, RcppArmadillo Suggests: testthat, survival Yi-Juan Hu <yijuanhu@bicmr.pku.edu.cn> Comprehensive R Archive Network (CRAN) Yi-Juan Hu [aut, cre] GPL (>= 2) 2026-05-04 application/tgz https://CRAN.R-project.org/package=LOCOM2 doi:10.32614/CRAN.package.LOCOM2