<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Latency Analysis in Epidemiological Studies Using Weighted
Cumulative Exposures</dc:title>
  <dc:title>R package LatencyA version 1.0.2</dc:title>
  <dc:description>Implements weighted cumulative exposure Cox proportional hazards
    models for latency analysis with repeatedly measured, time-varying
    exposures. Instead of entering every lagged exposure as a separate and
    highly correlated covariate, the lag-specific log hazard ratios are
    constrained to follow a smooth function of the time since exposure,
    parameterized by natural cubic splines or polynomials, so that the
    susceptible window of an exposure can be identified from the estimated
    lag-risk curve. Functions are provided to fit models with a
    prespecified number of knots or polynomial degree, to select the number
    of knots by a grid search or the spline terms by a stepwise search using
    the Akaike or Bayesian information criterion, and to extract
    lag-specific log hazard ratios with their variances. For the
    data-driven model selection procedures, inference is based on a cluster
    bootstrap that resamples subjects, which can be run sequentially or in
    parallel. The methods are described in Guo, Qian, Wang, Wang, Rosner and
    Wang (2026) "Taking Into Account the Susceptible Window for Exposures in
    Cox Proportional Hazards Model: A Way Using Splines to Model the Lag-Risk
    Relationship" &lt;doi:10.1002/sim.70755&gt;.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.1.0)</dc:relation>
  <dc:relation>Imports: Hmisc, survival, stats, MASS, stringr, future, furrr</dc:relation>
  <dc:creator>Fuyu Guo &lt;fuyuguo@hsph.harvard.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Fuyu Guo [aut, cre],
  Zihan Qian [aut],
  Molin Wang [aut]</dc:contributor>
  <dc:rights>MIT + file LICENSE (https://CRAN.R-project.org/package=LatencyA/LICENSE)</dc:rights>
  <dc:date>2026-10-21</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=LatencyA</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.LatencyA</dc:identifier>
</oai_dc:dc>
