This function takes a vector or matrix of data and smooths
    the data with an improved Savitzky Golay transform. The Savitzky-Golay
    method for data smoothing and differentiation calculates convolution
    weights using Gram polynomials that exactly reproduce the results of
    least-squares polynomial regression. Use of the Savitzky-Golay
    method requires specification of both filter length and
    polynomial degree to calculate convolution weights. For maximum
    smoothing of statistical noise in data, polynomials with
    low degrees are desirable, while a high polynomial degree
    is necessary for accurate reproduction of peaks in the data.
    Extension of the least-squares regression formalism with
    statistical testing of additional terms of polynomial degree
    to a heuristically chosen minimum for each data window leads
    to an adaptive-degree polynomial filter (ADPF). Based on noise
    reduction for data that consist of pure noise and on signal
    reproduction for data that is purely signal, ADPF performed
    nearly as well as the optimally chosen fixed-degree
    Savitzky-Golay filter and outperformed sub-optimally chosen
    Savitzky-Golay filters. For synthetic data consisting of noise
    and signal, ADPF outperformed both optimally chosen and
    sub-optimally chosen fixed-degree Savitzky-Golay filters. See Barak, P. (1995) <doi:10.1021/ac00113a006> for more information.

Obtain overlapping clustering models for object-by-variable data
        matrices using the Additive Profile Clustering (ADPROCLUS) method. 
        Also contains the low dimensional ADPROCLUS method 
        for simultaneous dimension reduction and overlapping clustering. 
        For reference see Depril, Van Mechelen, Mirkin (2008) 
        <doi:10.1016/j.csda.2008.04.014> and Depril, Van Mechelen, Wilderjans 
        (2012) <doi:10.1007/s00357-012-9112-5>.

Provides the functions for planning and conducting a
  clinical trial with adaptive sample size determination. Maximal statistical
  efficiency will be exploited even when dramatic or multiple adaptations
  are made. Such a trial consists of adaptive determination of sample size
  at an interim analysis and implementation of frequentist statistical test at the
  interim and final analysis with a prefixed significance level. The required
  assumptions for the stage-wise test statistics are independent and stationary
  increments and normality. Predetermination of adaptation rule is not required.