Implementation of the nonparametric bounds for the average
    causal effect under an instrumental variable model by Balke and Pearl
    (Bounds on Treatment Effects from Studies with Imperfect Compliance,
    JASA, 1997, 92, 439, 1171-1176). The package can calculate bounds for
    a binary outcome, a binary treatment/phenotype, and an instrument with
    either 2 or 3 categories. The package implements bounds for situations
    where these 3 variables are measured in the same dataset (trivariate
    data) or where the outcome and instrument are measured in one study
    and the treatment/phenotype and instrument are measured in another
    study (bivariate data).

Implements biplot (2d and 3d) of multivariate data based
             on principal components analysis and diagnostic tools of the quality of the reduction.

Calculates nonparametric pointwise confidence intervals for the survival distribution for right censored data, and for medians [Fay and Brittain <DOI:10.1002/sim.6905>]. Has two-sample tests for dissimilarity (e.g., difference, ratio or odds ratio) in survival at a fixed time, and differences in medians [Fay, Proschan, and Brittain <DOI:10.1111/biom.12231>]. Basically, the package gives exact inference methods for one- and two-sample exact inferences for Kaplan-Meier curves (e.g., generalizing Fisher's exact test to allow for right censoring), which are especially important for latter parts of the survival curve, small sample sizes or heavily censored data. Includes mid-p options.

Functions for drawing boxplots for data on (the boundary of) a unit circle (i.e., circular and axial data), from Buttarazzi D., Pandolfo G., Porzio G.C. (2018) <doi:10.1111/biom.12889>.

Model-based clustering using Bayesian parsimonious Gaussian mixture models.
  MCMC (Markov chain Monte Carlo) are used for parameter estimation. The RJMCMC (Reversible-jump Markov chain Monte Carlo) is used for model selection. 
  GREEN et al. (1995) <doi:10.1093/biomet/82.4.711>.

Bayesian purity model to estimate tumor purity using methylation 
    array data (DNA methylation Infinium 450K array data) without reference samples.