A robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.

Opens complete record(s) with .gb extension from the NCBI/GenBank Nucleotide database and returns a list containing shaped record(s). These kind of files contains detailed records of DNA samples (locus, organism, type of sequence, source of the sequence...). An example of record can be found at <https://www.ncbi.nlm.nih.gov/nuccore/HE799070>.

Implements a high performance C++ parser 
    for 'ActiGraph' 'GT3X'/'GT3X+' data format (with extension '.gt3x') 
    for 'accelerometer' samples. Activity samples can be easily read into a
    matrix or data.frame.  This allows for storing the raw 'accelerometer' 
    samples in the original binary format to reserve space.

Loads Axon Binary Files (both 'ABF' and 'ABF2') created by Axon Instruments/Molecular Devices software such as 'pClamp'.

Downloads, imports, and tidies time series data from the 
    Australian Bureau of Statistics <https://www.abs.gov.au/>.

Identifies and reads Windows BMP, JPEG, PNG, and TIFF format bitmap
    images. Identification defaults to the use of the magic number embedded in
    the file rather than the file extension. Reading of JPEG and PNG image
    depends on libjpg and libpng libraries. See file INSTALL for details if
    necessary.

Reads data files acquired by Bruker Daltonics' matrix-assisted
    laser desorption/ionization-time-of-flight mass spectrometer of the *flex
    series.