Diffusion Weighted Imaging (DWI) is a Magnetic Resonance Imaging
             modality, that measures diffusion of water in tissues like the human
             brain. The package contains R-functions to process diffusion-weighted
             data. The functionality includes diffusion tensor imaging (DTI),
             diffusion kurtosis imaging (DKI), modeling for high angular resolution
             diffusion weighted imaging (HARDI) using Q-ball-reconstruction and
             tensor mixture models, several methods for structural adaptive
             smoothing including POAS and msPOAS, and a streamline fiber tracking
             for tensor and tensor mixture models.
             The package provides functionality to manipulate and visualize results
             in 2D and 3D.

A series of functions which aid in both simulating and determining the properties of finite, discrete-time, discrete state markov chains.  Two functions (DTMC, MultDTMC) produce n iterations of a Markov Chain(s)  based on transition probabilities and an initial distribution.  The function FPTime determines the first passage time into each state.  The function statdistr determines the stationary distribution of a Markov Chain.

Compute the dynamic threshold panel model suggested by (Stephanie Kremer, Alexander Bick and Dieter Nautz (2013) <doi:10.1007/s00181-012-0553-9>) in which they extended the (Hansen (1999) <doi: 10.1016/S0304-4076(99)00025-1>) original static panel threshold estimation and the Caner and (Hansen (2004) <doi:10.1017/S0266466604205011>) cross-sectional instrumental variable threshold model, where generalized methods of moments type estimators are used.

Provides the dose transition pathways (DTP) to project in advance
    the doses recommended by a model-based design for subsequent patients (stay,
    escalate, deescalate or stop early) using all the accumulated toxicity
    information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP
    can be used as a design and an operational tool and can be displayed as a
    table or flow diagram. The 'dtpcrm' package also provides the modified
    continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with
    added practical considerations to allow stopping early when there is
    sufficient evidence that the lowest dose is too toxic and/or there is a
    sufficient number of patients dosed at the maximum tolerated dose.