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AutoScore is a novel machine learning framework to automate the development of interpretable clinical scoring models. AutoScore consists of six modules: 1) variable ranking with machine learning, 2) variable transformation, 3) score derivation, 4) model selection, 5) domain knowledge-based score fine-tuning, and 6) performance evaluation. The original AutoScore structure is elaborated in this article and its flowchart is shown in the following figure. AutoScore was originally designed for binary outcomes and later extended to survival outcomes and ordinal outcomes. AutoScore could seamlessly generate risk scores using a parsimonious set of variables for different types of clinical outcomes, which can be easily implemented and validated in clinical practice. Moreover, it enables users to build transparent and interpretable clinical scores quickly in a straightforward manner.
Please go to our bookdown page for a full tutorial on AutoScore usage.
The five pipeline functions constitute the 5-step AutoScore-based process for generating point-based clinical scores for binary, survival and ordinal outcomes.
This 5-step process gives users the flexibility of customization (e.g., determining the final list of variables according to the parsimony plot, and fine-tuning the cutoffs in variable transformation):
AutoScore_rank()or
AutoScore_rank_Survival() or
AutoScore_rank_Ordinal() - Rank variables with machine
learning (AutoScore Module 1)AutoScore_parsimony() or
AutoScore_parsimony_Survival() or
AutoScore_parsimony_Ordinal() - Select the best model with
parsimony plot (AutoScore Modules 2+3+4)AutoScore_weighting() or
AutoScore_weighting_Survival() or
AutoScore_weighting_Ordinal() - Generate the initial score
with the final list of variables (Re-run AutoScore Modules 2+3)AutoScore_fine_tuning() or
AutoScore_fine_tuning_Survival() or
AutoScore_fine_tuning_Ordinal() - Fine-tune the score by
revising cut_vec with domain knowledge (AutoScore Module
5)AutoScore_testing() or
AutoScore_testing_Survival() or
AutoScore_testing_Ordinal() - Evaluate the final score with
ROC analysis (AutoScore Module 6)We also include several optional functions in the package, which could help with data analysis and result reporting.
Please go to our bookdown page for a full tutorial on AutoScore usage.
Xie F, Ning Y, Yuan H, Goldstein BA, Ong MEH, Liu N, Chakraborty B. AutoScore-Survival: Developing interpretable machine learning-based time-to-event scores with right-censored survival data. Journal of Biomedical Informatics 2022; 125: 103959.
Saffari SE, Ning Y, Xie F, Chakraborty B, Volovici V, Vaughan R, Ong MEH, Liu N, AutoScore-Ordinal: An interpretable machine learning framework for generating scoring models for ordinal outcomes, arXiv:2202.08407.
Ning Y, Li S, Ong ME, Xie F, Chakraborty B, Ting DS, Liu N. A novel interpretable machine learning system to generate clinical risk scores: An application for predicting early mortality or unplanned readmission in a retrospective cohort study. PLOS Digit Health 2022; 1(6): e0000062.
Install from GitHub or CRAN：
# From Github
install.packages("devtools")
library(devtools)
install_github(repo = "nliulab/AutoScore", build_vignettes = TRUE)
# From CRAN (recommended)
install.packages("AutoScore")Load AutoScore package:
library(AutoScore)Please go to our bookdown page for a full tutorial on AutoScore usage.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.