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Provides tools to model overdispersed vaccine-specific memory B cell frequencies using Beta-Binomial generalized linear models, specifically designed for analyzing vaccine-induced cellular immune responses. Includes method-of-moments dispersion estimation, likelihood ratio testing across experimental arms, and Monte Carlo simulation frameworks to calculate statistical power and Type I error rates. The methodologies are directly motivated by the analysis of immunology data in 'Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial' (Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.
| Version: | 0.1.0 |
| Depends: | R (≥ 4.1.0) |
| Imports: | doParallel, foreach, glmmTMB, parallel, stats, utils |
| Suggests: | testthat (≥ 3.0.0) |
| Published: | 2026-10-07 |
| DOI: | 10.32614/CRAN.package.BBMBC (may not be active yet) |
| Author: | Andrew Shin [aut, cre] |
| Maintainer: | Andrew Shin <ashin2 at uw.edu> |
| License: | MIT + file LICENSE |
| NeedsCompilation: | no |
| CRAN checks: | BBMBC results |
| Reference manual: | BBMBC.html , BBMBC.pdf |
| Package source: | BBMBC_0.1.0.tar.gz |
| Windows binaries: | r-devel: not available, r-release: not available, r-oldrel: not available |
| macOS binaries: | r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.