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The hima function is described in:

Zhang H, Zheng Y, Zhang Z, Gao T, Joyce B, Yoon G, Zhang W, Schwartz J, Just A, Colicino E, Vokonas P, Zhao L, Lv J, Baccarelli A, Hou L, Liu L (2016). “Estimating and Testing High-dimensional Mediation Effects in Epigenetic Studies.” Bioinformatics, 32(20), 3150-3154. doi:10.1093/bioinformatics/btw351.

The survHIMA function is described in:

Zhang H, Zheng Y, Hou L, Liu L (2021). “Mediation Analysis for Survival Data with High-Dimensional Mediators.” Bioinformatics, 37(21), 3815-3821. doi:10.1093/bioinformatics/btab564.

The microHIMA function is described in:

Zhang H, Chen J, Feng Y, Wang C, Li H, Liu L (2021). “Mediation effect selection in high-dimensional and compositional microbiome data.” Statistics in medicine, 40(4), 885-896. doi:10.1002/sim.8808.

The delassoHIMA function is described in:

Chamila P, Zhang H, Zheng Y, Hou L, Qu A, Zheng C, Xie K, Liu L (2022). “HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data.” BMC Bioinformatics, 23(1), 296. doi:10.1186/s12859-022-04748-1.

The qHIMA function is described in:

Zhang H, Hong X, Zheng Y, Hou L, Zheng C, Wang X, Liu L (2024). “High-Dimensional Quantile Mediation Analysis with Application to a Birth Cohort Study of Mother–Newborn Pairs.” Bioinformatics, 40(2), btae055. doi:10.1093/bioinformatics/btae055.

The eHIMA function is described in:

Bai X, Zheng Y, Hou L, Zheng C, Liu L, Zhang H (2024). “An Efficient Testing Procedure for High-dimensional Mediators with FDR Control.” Statistics in Biosciences. doi:10.1007/s12561-024-09447-4.

Corresponding BibTeX entries:

  @Article{HIMA,
    title = {{Estimating and Testing High-dimensional Mediation Effects
      in Epigenetic Studies}},
    author = {Haixiang Zhang and Yinan Zheng and Zhou Zhang and Tao Gao
      and Brian Joyce and Grace Yoon and Wei Zhang and Joel Schwartz
      and Allan Just and Elena Colicino and Pantel Vokonas and Lihui
      Zhao and Jinchi Lv and Andrea Baccarelli and Lifang Hou and Lei
      Liu},
    journal = {Bioinformatics},
    year = {2016},
    volume = {32},
    number = {20},
    pages = {3150-3154},
    doi = {10.1093/bioinformatics/btw351},
    pubmed = {27357171},
  }
  @Article{survHIMA,
    title = {{Mediation Analysis for Survival Data with
      High-Dimensional Mediators}},
    author = {Haixiang Zhang and Yinan Zheng and Lifang Hou and Lei
      Liu},
    journal = {Bioinformatics},
    year = {2021},
    volume = {37},
    number = {21},
    pages = {3815-3821},
    doi = {10.1093/bioinformatics/btab564},
    pubmed = {34343267},
  }
  @Article{microHIMA,
    title = {{Mediation effect selection in high-dimensional and
      compositional microbiome data}},
    author = {Haixiang Zhang and Jun Chen and Yang Feng and Chan Wang
      and Huilin Li and Lei Liu},
    journal = {Statistics in medicine},
    year = {2021},
    volume = {40},
    number = {4},
    pages = {885-896},
    doi = {10.1002/sim.8808},
    pubmed = {33205470},
  }
  @Article{delassoHIMA,
    title = {{HIMA2: high-dimensional mediation analysis and its
      application in epigenome-wide DNA methylation data}},
    author = {Perera Chamila and Haixiang Zhang and Yinan Zheng and
      Lifang Hou and Annie Qu and Cheng Zheng and Ke Xie and Lei Liu},
    journal = {BMC Bioinformatics},
    year = {2022},
    volume = {23},
    number = {1},
    pages = {296},
    doi = {10.1186/s12859-022-04748-1},
    pubmed = {35879655},
  }
  @Article{qHIMA,
    title = {{High-Dimensional Quantile Mediation Analysis with
      Application to a Birth Cohort Study of Mother–Newborn Pairs}},
    author = {Haixiang Zhang and Xiumei Hong and Yinan Zheng and Lifang
      Hou and Cheng Zheng and Xiaobin Wang and Lei Liu},
    journal = {Bioinformatics},
    year = {2024},
    volume = {40},
    number = {2},
    pages = {btae055},
    doi = {10.1093/bioinformatics/btae055},
    pubmed = {38290773},
  }
  @Article{eHIMA,
    title = {{An Efficient Testing Procedure for High-dimensional
      Mediators with FDR Control}},
    author = {Xueyan Bai and Yinan Zheng and Lifang Hou and Cheng Zheng
      and Lei Liu and Haixiang Zhang},
    journal = {Statistics in Biosciences},
    year = {2024},
    doi = {10.1007/s12561-024-09447-4},
  }

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.