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Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a staple technology in structural proteomics. HaDeX provides a analytic workflow for HDX-MS data available as a standalone GUI (https://sourceforge.net/projects/HaDeX/), web server (https://hadex.mslab-ibb.pl/) and the R package available on CRAN (https://cran.r-project.org/web/packages/HaDeX/index.html).
To run HaDeX GUI locally on Windows, install it using the following binary file: https://sourceforge.net/projects/HaDeX/files/HaDeX_setup.exe/download
You can install the latest development version of the package:
devtools::install_github("hadexversum/HaDeX")or the latest version available on CRAN:
install.packages("HaDeX")After installation GUI can be accessed locally:
library(HaDeX)
HaDeX_gui()The HaDeX documentation is available online.
Puchala W, Burdukiewicz M, Kistowski M, Dabrowska KA, Badaczewska-Dawid AE, Cysewski D and Dadlez M (2020). HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data. Bioinformatics, 10.1093/bioinformatics/btaa587.
This work is supported by Foundation of Polish Science (TEAM TECH CORE FACILITY/2016-2/2 Mass Spectrometry of Biopharmaceuticals - improved methodologies for qualitative, quantitative and structural characterization of drugs, proteinaceous drug targets and diagnostic molecules).
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.