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LOCOM2: A Logistic Regression Model for Testing Microbial Differential Abundance

Testing differential abundance at individual taxa and in a whole microbial community. The tests are based on the log-ratio of relative abundances. The tests accommodate continuous, discrete (binary, categorical), and multivariate traits, and allow adjustment of confounders. For more details see He (2026) <doi:10.64898/2026.04.07.716976>.

Version: 1.0
Depends: R (≥ 3.5.0)
Imports: Rcpp (≥ 1.0.11), stats, permute, parallel, BiocParallel, matrixStats, abind, car
LinkingTo: Rcpp, RcppArmadillo
Suggests: testthat, survival
Published: 2026-05-04
DOI: 10.32614/CRAN.package.LOCOM2 (may not be active yet)
Author: Yi-Juan Hu [aut, cre]
Maintainer: Yi-Juan Hu <yijuanhu at bicmr.pku.edu.cn>
BugReports: https://github.com/yijuanhu/LOCOM2/issues
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
URL: https://github.com/yijuanhu/LOCOM2
NeedsCompilation: yes
Materials: README
CRAN checks: LOCOM2 results

Documentation:

Reference manual: LOCOM2.html , LOCOM2.pdf

Downloads:

Package source: LOCOM2_1.0.tar.gz
Windows binaries: r-devel: LOCOM2_1.0.zip, r-release: not available, r-oldrel: LOCOM2_1.0.zip
macOS binaries: r-release (arm64): LOCOM2_1.0.tgz, r-oldrel (arm64): LOCOM2_1.0.tgz, r-release (x86_64): LOCOM2_1.0.tgz, r-oldrel (x86_64): LOCOM2_1.0.tgz

Linking:

Please use the canonical form https://CRAN.R-project.org/package=LOCOM2 to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.