| Type: | Package |
| Title: | Treatment Allocation in Clinical Trials by the Maximal Procedure |
| Version: | 0.1-6 |
| Date: | 2024-01-15 |
| Author: | Ignacio López-de-Ullibarri [aut, cre] |
| Maintainer: | Ignacio López-de-Ullibarri <ignacio.lopezdeullibarri@udc.es> |
| Description: | Performs treatment allocation in two-arm clinical trials by the maximal procedure described by Berger et al. (2003) <doi:10.1002/sim.1538>. To that end, the algorithm provided by Salama et al. (2008) <doi:10.1002/sim.3014> is implemented. |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| Imports: | Rcpp (≥ 1.0.5) |
| LinkingTo: | Rcpp, BH |
| Depends: | R (≥ 4.1.0) |
| Suggests: | knitr, pinp, rmarkdown |
| VignetteBuilder: | knitr |
| NeedsCompilation: | yes |
| Encoding: | UTF-8 |
| Packaged: | 2024-01-15 11:08:53 UTC; ilu |
| Repository: | CRAN |
| Date/Publication: | 2024-01-15 12:20:02 UTC |
Treatment Allocation in Clinical Trials by the Maximal Procedure
Description
Performs treatment allocation in two-arm clinical trials by the maximal procedure described by Berger et al. (2003) <doi:10.1002/sim.1538>. To that end, the algorithm provided by Salama et al. (2008) <doi:10.1002/sim.3014> is implemented.
Details
Index of help topics:
MPBoost-package Treatment Allocation in Clinical Trials by the
Maximal Procedure
mpboost Compute Allocation Sequences by the Maximal
Procedure
Author(s)
Ignacio López-de-Ullibarri
Maintainer: Ignacio López-de-Ullibarri <ignacio.lopezdeullibarri@udc.es>
References
Berger, V. W., Ivanova, A., Knoll, M. D. (2003). Minimizing predictability while retaining balance through the use of less restrictive randomization procedures. Statistics in Medicine, 22: 3017-3028. doi:10.1002/sim.1538.
Salama, I., Ivanova, A., Qaqish, B. (2008). Efficient generation of constrained block allocation sequences. Statistics in Medicine, 27, 1421-1428. doi:10.1002/sim.3014.
Compute Allocation Sequences by the Maximal Procedure
Description
This function produces a treatment assignment sequence generated according to the maximal procedure of Berger et al. (2003). It is an implementation of the algorithm proposed by Salama et al. (2008).
Usage
mpboost(N1, N2, MTI = 2L)
Arguments
N1 |
An integer specifying the size of the sample assigned to treatment 1. |
N2 |
An integer specifying the size of the sample assigned to treatment 2. |
MTI |
An integer specifying the maximum tolerated imbalance (MTI). The default is 2. |
Value
A vector of N1 1's and N2 2's representing the allocation sequence.
Note
See the package's vignette for more details and further examples of the use of the function.
References
Berger, V. W., Ivanova, A., Knoll, M. D. (2003). Minimizing predictability while retaining balance through the use of less restrictive randomization procedures. Statistics in Medicine, 22: 3017-3028. doi:10.1002/sim.1538.
Salama, I., Ivanova, A., Qaqish, B. (2008). Efficient generation of constrained block allocation sequences. Statistics in Medicine, 27, 1421-1428. doi:10.1002/sim.3014.
Examples
#\donttest{
mpboost(N1 = 25, N2 = 25, MTI = 3)
#}