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PKbioanalysis

PKbioanalysis is an R package designed to facilitate the integration of pharmacokinetic (PK) and bioanalytical data analysis. The overarching goal of this package is to provide a streamlined and standardized approach to chromatography-based pharmacokinetic studies starting from study design to PK analysis and reporting.

Installation

You can install the released version of PKbioanalysis from CRAN with:

install.packages("PKbioanalysis")

Or the development version from GitHub with:

remotes::install_github("OmarAshkar/PKbioanalysis")

Main Features

• 96-well plate design and visualization
• Support Pharmacokinetic samples attributes on the plate
• Automatically propagate and design injection sequences
• Export injection sequences to CSV compatible with Masslynx and MassHunter
• Interactive dilution scheme with unit conversion

Milestones

• Support import peak areas from TargetLynx or other formats
• Support interactive chromatography integration and visualization
• Linearity
• Suitability
• MLE of additive and proportional errors
• Automatically estimate LOD
• Estimate UAD (dilution threshold) recommendation
• Export to NONMEM-formated dataset

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.