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Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.
| Version: | 1.3 |
| Depends: | methods, stats, rARPACK, Matrix, CompQuadForm |
| Published: | 2023-10-01 |
| DOI: | 10.32614/CRAN.package.POINT |
| Author: | Rachel Marceau West, Shannon T. Holloway |
| Maintainer: | Shannon T. Holloway <shannon.t.holloway at gmail.com> |
| License: | GPL-2 |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | POINT results |
| Reference manual: | POINT.pdf |
| Package source: | POINT_1.3.tar.gz |
| Windows binaries: | r-devel: POINT_1.3.zip, r-release: POINT_1.3.zip, r-oldrel: POINT_1.3.zip |
| macOS binaries: | r-release (arm64): POINT_1.3.tgz, r-oldrel (arm64): POINT_1.3.tgz, r-release (x86_64): POINT_1.3.tgz, r-oldrel (x86_64): POINT_1.3.tgz |
| Old sources: | POINT archive |
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