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Phase12Compare: Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.

Version: 1.5
Imports: Rcpp (≥ 0.12.18), mvtnorm
LinkingTo: Rcpp, RcppArmadillo
Published: 2020-07-31
DOI: 10.32614/CRAN.package.Phase12Compare
Author: Andrew G Chapple
Maintainer: Andrew G Chapple <achapp at lsuhsc.edu>
License: GPL-2
NeedsCompilation: yes
CRAN checks: Phase12Compare results

Documentation:

Reference manual: Phase12Compare.pdf

Downloads:

Package source: Phase12Compare_1.5.tar.gz
Windows binaries: r-devel: Phase12Compare_1.5.zip, r-release: Phase12Compare_1.5.zip, r-oldrel: Phase12Compare_1.5.zip
macOS binaries: r-release (arm64): Phase12Compare_1.5.tgz, r-oldrel (arm64): Phase12Compare_1.5.tgz, r-release (x86_64): Phase12Compare_1.5.tgz, r-oldrel (x86_64): Phase12Compare_1.5.tgz
Old sources: Phase12Compare archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=Phase12Compare to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.