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The PubChemR package introduces a pivotal function,
get_pug_rest, designed to facilitate seamless access to the
vast chemical data repository of PubChem. This function leverages the
capabilities of PubChem’s Power User Gateway (PUG) REST service,
providing a straightforward and efficient means for users to
programmatically interact with PubChem’s extensive database. This
vignette aims to elucidate the structure and usage of the PUG REST
service, offering a range of illustrative use cases to aid new users in
understanding its operation and constructing effective requests.
PUG REST, standing for Power User Gateway RESTful interface, is a simplified access route to PubChem’s data and services. It is designed for scripts, web page embedded JavaScript, and third-party applications, eliminating the need for the more complex XML and SOAP envelopes required by other PUG variants. PUG REST’s design revolves around the PubChem identifier (SID for substances, CID for compounds, and AID for assays) and is structured into three main request components: input (identifiers), operation (actions on identifiers), and output (desired information format).
Usage Policy:
get_pug_restOverview
The get_pug_rest function in the PubChemR
package provides a versatile interface to access a wide range of
chemical data from the PubChem database. This section of the vignette
focuses on various methods to retrieve chemical structure information
and other related data using the PUG REST service. The function is
designed to be flexible, accommodating different input methods,
operations, and output formats.
This function sends a request to the PubChem PUG REST API to retrieve various types of data for a given identifier. It supports fetching data in different formats and allows saving the output.
get_pug_rest(
identifier = NULL,
namespace = "cid",
domain = "compound",
operation = NULL,
output = "JSON",
searchtype = NULL,
property = NULL,
options = NULL,
save = FALSE,
dpi = 300,
path = NULL,
file_name = NULL,
...
)Arguments
identifier: A vector of identifiers for the query, either numeric or character. This is the main input for querying the PubChem database.
namespace: A character string specifying the namespace for the request. Default is ‘cid’. This defines the type of identifier being used, such as ‘cid’ (Compound ID), ‘sid’ (Substance ID), etc.
domain: A character string specifying the domain for the request. Default is ‘compound’. This indicates the type of entity being queried, such as ‘compound’, ‘substance’, etc.
operation: An optional character string specifying the operation for the request. This can be used to specify particular actions or methods within the API.
output: A character string specifying the output format. Possible values are ‘SDF’, ‘JSON’, ‘JSONP’, ‘CSV’, ‘TXT’, and ‘PNG’. Default is ‘JSON’. This defines the format in which the data will be returned.
searchtype: An optional character string specifying the search type. This allows for specifying the nature of the search being performed.
property: An optional character string specifying the property for the request. This can be used to filter or specify particular properties of the data being retrieved.
options: A list of additional options for the request. This allows for further customization and fine-tuning of the request parameters.
save: A logical value indicating whether to save the output as a file or image. Default is FALSE. When set to TRUE, the function will save the retrieved data to a specified file.
dpi: An integer specifying the DPI for image output. Default is 300. This is relevant when the output format is an image, determining the resolution of the saved image.
path: A character string specifying the directory path where the file will be saved. If not provided, the current working directory is used.
file_name: A character string of length 1. Defines the name of the file (without file extension) to save. If NULL, the default file name is set as “files_downloaded”.
…: Additional arguments to be passed to the request.
Value
The function returns different types of content based on the specified output format:
JSON: Returns a list. CSV and TXT: Returns a data frame. SDF: Returns an SDF file of the requested identifier. PNG: Returns an image object or saves an image file.
In the context of the PubChem PUG REST API, the input methods define how records of interest are specified for a request. There are several ways to define this input, with the most common methods being outlined below:
1. By Identifier: The most straightforward method to specify input is by using identifiers directly. These identifiers can be Substance IDs (SIDs) or Compound IDs (CIDs). For example, to retrieve the names of a substance with CID 2244, you can use the get_pug_rest function as follows:
result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: CID
#> - Operation: <NULL>
#> - Identifier: 2244
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.The pubChemData function then processes the result to extract and display the retrieved data. Here’s an interpretation of the output for CID 2244:
pubChemDataResult <- pubChemData(result)The JSON response contains detailed information about the compound identified by CID 2244. The PC_Compounds array holds the compound data, and within it, each element corresponds to a specific compound.
For CID 2244, the following information is retrieved:
ID: Confirms the compound identifier is CID 2244.
pubChemDataResult$PC_Compounds[[1]]$id
#> $id
#> cid
#> 2244Atoms: Details the atomic composition, with an aid array listing the atom IDs and an element array listing the atomic numbers (e.g., 6 for carbon, 8 for oxygen, 1 for hydrogen).
pubChemDataResult$PC_Compounds[[1]]$atoms
#> $aid
#> [1] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
#>
#> $element
#> [1] 8 8 8 8 6 6 6 6 6 6 6 6 6 1 1 1 1 1 1 1 1Bonds: Describes the bonds between atoms, including arrays for the IDs of the atoms involved (aid1 and aid2) and the bond order.
pubChemDataResult$PC_Compounds[[1]]$bonds
#> $aid1
#> [1] 1 1 2 2 3 4 5 5 6 6 7 7 8 8 9 9 10 12 13 13 13
#>
#> $aid2
#> [1] 5 12 11 21 11 12 6 7 8 11 9 14 10 15 10 16 17 13 18 19 20
#>
#> $order
#> [1] 1 1 1 1 2 2 1 2 2 1 1 1 1 1 2 1 1 1 1 1 1Coordinates: Provides the spatial coordinates (x and y) for each atom, which can be used to visualize the molecular structure.
pubChemDataResult$PC_Compounds[[1]]$coords
#> [[1]]
#> [[1]]$type
#> [1] 1 5 255
#>
#> [[1]]$aid
#> [1] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
#>
#> [[1]]$conformers
#> [[1]]$conformers[[1]]
#> [[1]]$conformers[[1]]$x
#> [1] 3.7320 6.3301 4.5981 2.8660 4.5981 5.4641 4.5981 6.3301 5.4641 6.3301
#> [11] 5.4641 2.8660 2.0000 4.0611 6.8671 5.4641 6.8671 2.3100 1.4631 1.6900
#> [21] 6.3301
#>
#> [[1]]$conformers[[1]]$y
#> [1] -0.0600 1.4400 1.4400 -1.5600 -0.5600 -0.0600 -1.5600 -0.5600 -2.0600
#> [10] -1.5600 0.9400 -0.5600 -0.0600 -1.8700 -0.2500 -2.6800 -1.8700 0.4769
#> [19] 0.2500 -0.5969 2.0600
#>
#> [[1]]$conformers[[1]]$style
#> [[1]]$conformers[[1]]$style$annotation
#> [1] 8 8 8 8 8 8
#>
#> [[1]]$conformers[[1]]$style$aid1
#> [1] 5 5 6 7 8 9
#>
#> [[1]]$conformers[[1]]$style$aid2
#> [1] 6 7 8 9 10 10Charge: Indicates the compound’s charge, which is 0 in this case.
pubChemDataResult$PC_Compounds[[1]]$charge
#> [1] 0Properties: Lists various properties of the compound, including:
Compound Complexity: A measure of the molecular complexity.
pubChemDataResult$PC_Compounds[[1]]$props[[2]]
#> $urn
#> $urn$label
#> [1] "Compound Complexity"
#>
#> $urn$datatype
#> [1] 7
#>
#> $urn$implementation
#> [1] "E_COMPLEXITY"
#>
#> $urn$version
#> [1] "3.4.8.18"
#>
#> $urn$software
#> [1] "Cactvs"
#>
#> $urn$source
#> [1] "Xemistry GmbH"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> fval
#> 212Hydrogen Bond Acceptor/Donor Count: Indicates the number of hydrogen bond acceptors and donors.
pubChemDataResult$PC_Compounds[[1]]$props[[3]]
#> $urn
#> $urn$label
#> [1] "Count"
#>
#> $urn$name
#> [1] "Hydrogen Bond Acceptor"
#>
#> $urn$datatype
#> [1] 5
#>
#> $urn$implementation
#> [1] "E_NHACCEPTORS"
#>
#> $urn$version
#> [1] "3.4.8.18"
#>
#> $urn$software
#> [1] "Cactvs"
#>
#> $urn$source
#> [1] "Xemistry GmbH"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> ival
#> 4pubChemDataResult$PC_Compounds[[1]]$props[[4]]
#> $urn
#> $urn$label
#> [1] "Count"
#>
#> $urn$name
#> [1] "Hydrogen Bond Donor"
#>
#> $urn$datatype
#> [1] 5
#>
#> $urn$implementation
#> [1] "E_NHDONORS"
#>
#> $urn$version
#> [1] "3.4.8.18"
#>
#> $urn$software
#> [1] "Cactvs"
#>
#> $urn$source
#> [1] "Xemistry GmbH"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> ival
#> 1Rotatable Bond Count: The number of rotatable bonds, which impacts the molecule’s flexibility.
pubChemDataResult$PC_Compounds[[1]]$props[[5]]
#> $urn
#> $urn$label
#> [1] "Count"
#>
#> $urn$name
#> [1] "Rotatable Bond"
#>
#> $urn$datatype
#> [1] 5
#>
#> $urn$implementation
#> [1] "E_NROTBONDS"
#>
#> $urn$version
#> [1] "3.4.8.18"
#>
#> $urn$software
#> [1] "Cactvs"
#>
#> $urn$source
#> [1] "Xemistry GmbH"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> ival
#> 3IUPAC Names: Various standardized names for the compound, such as “2-acetoxybenzoic acid” and “2-acetyloxybenzoic acid”.
pubChemDataResult$PC_Compounds[[1]]$props[[7]]
#> $urn
#> $urn$label
#> [1] "IUPAC Name"
#>
#> $urn$name
#> [1] "Allowed"
#>
#> $urn$datatype
#> [1] 1
#>
#> $urn$version
#> [1] "2.7.0"
#>
#> $urn$software
#> [1] "Lexichem TK"
#>
#> $urn$source
#> [1] "OpenEye Scientific Software"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> sval
#> "2-acetoxybenzoic acid"InChI and InChIKey: Standardized identifiers for the chemical structure.
pubChemDataResult$PC_Compounds[[1]]$props[[13]]
#> $urn
#> $urn$label
#> [1] "InChI"
#>
#> $urn$name
#> [1] "Standard"
#>
#> $urn$datatype
#> [1] 1
#>
#> $urn$version
#> [1] "1.0.6"
#>
#> $urn$software
#> [1] "InChI"
#>
#> $urn$source
#> [1] "iupac.org"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> sval
#> "InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)"pubChemDataResult$PC_Compounds[[1]]$props[[14]]
#> $urn
#> $urn$label
#> [1] "InChIKey"
#>
#> $urn$name
#> [1] "Standard"
#>
#> $urn$datatype
#> [1] 1
#>
#> $urn$version
#> [1] "1.0.6"
#>
#> $urn$software
#> [1] "InChI"
#>
#> $urn$source
#> [1] "iupac.org"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> sval
#> "BSYNRYMUTXBXSQ-UHFFFAOYSA-N"Log P: The partition coefficient, indicating the compound’s hydrophobicity.
pubChemDataResult$PC_Compounds[[1]]$props[[15]]
#> $urn
#> $urn$label
#> [1] "Log P"
#>
#> $urn$name
#> [1] "XLogP3"
#>
#> $urn$datatype
#> [1] 7
#>
#> $urn$version
#> [1] "3.0"
#>
#> $urn$source
#> [1] "sioc-ccbg.ac.cn"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> fval
#> 1.2Molecular Formula: The chemical formula of the compound, which is C9H8O4.
pubChemDataResult$PC_Compounds[[1]]$props[[17]]
#> $urn
#> $urn$label
#> [1] "Molecular Formula"
#>
#> $urn$datatype
#> [1] 1
#>
#> $urn$version
#> [1] "2.2"
#>
#> $urn$software
#> [1] "PubChem"
#>
#> $urn$source
#> [1] "ncbi.nlm.nih.gov"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> sval
#> "C9H8O4"Molecular Weight: The compound’s molecular weight, 180.16 g/mol.
pubChemDataResult$PC_Compounds[[1]]$props[[18]]
#> $urn
#> $urn$label
#> [1] "Molecular Weight"
#>
#> $urn$datatype
#> [1] 1
#>
#> $urn$version
#> [1] "2.2"
#>
#> $urn$software
#> [1] "PubChem"
#>
#> $urn$source
#> [1] "ncbi.nlm.nih.gov"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> sval
#> "180.16"SMILES: Canonical and isomeric Simplified Molecular Input Line Entry System (SMILES) strings, which are text representations of the chemical structure. Topological Polar Surface Area: A measure of the molecule’s surface area that can form hydrogen bonds.
pubChemDataResult$PC_Compounds[[1]]$props[[19]]
#> $urn
#> $urn$label
#> [1] "SMILES"
#>
#> $urn$name
#> [1] "Canonical"
#>
#> $urn$datatype
#> [1] 1
#>
#> $urn$version
#> [1] "2.3.0"
#>
#> $urn$software
#> [1] "OEChem"
#>
#> $urn$source
#> [1] "OpenEye Scientific Software"
#>
#> $urn$release
#> [1] "2021.10.14"
#>
#>
#> $value
#> sval
#> "CC(=O)OC1=CC=CC=C1C(=O)O"For multiple IDs, a vector of IDs can be used. For instance, to retrieve a CSV table of compound properties:
result <- get_pug_rest(identifier = c("1","2","3","4","5"), namespace = "cid", domain = "compound", property = c("MolecularFormula","MolecularWeight","CanonicalSMILES"), output = "CSV")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: CID
#> - Operation: <NULL>
#> - Identifier: 1, 2, ... and 3 more.
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.The output of this request, when processed with pubChemData, provides a data frame containing the specified properties for each CID:
pubChemData(result)
#> CID MolecularFormula MolecularWeight CanonicalSMILES
#> 1 1 C9H17NO4 203.24 CC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
#> 2 2 C9H18NO4+ 204.24 CC(=O)OC(CC(=O)O)C[N+](C)(C)C
#> 3 3 C7H8O4 156.14 C1=CC(C(C(=C1)C(=O)O)O)O
#> 4 4 C3H9NO 75.11 CC(CN)O
#> 5 5 C3H8NO5P 169.07 C(C(=O)COP(=O)(O)O)NEach row in the table corresponds to a different CID and lists the requested properties, facilitating easy comparison and further analysis.
2. By Name: In addition to using direct identifiers, you can refer to a chemical by its common name. This method allows users to search for compounds using familiar names instead of numerical identifiers. It’s important to note that a single name might correspond to multiple records in the PubChem database. For example, the name “glucose” can refer to several different compounds or isomers. Here’s how you can retrieve Compound IDs (CIDs) for “glucose”:
result <- get_pug_rest(identifier = "glucose", namespace = "name", domain = "compound", operation = "cids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: Name
#> - Operation: cids
#> - Identifier: glucose
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.The pubChemData function is then used to process the result and extract the retrieved data. The function retrieves the output in data frame. The output indicates that the search for “glucose” returned a single CID:
pubChemData(result)
#> Text
#> 1 5793This output reveals that the common name “glucose” corresponds to the CID 5793. This CID can then be used in further queries to retrieve detailed information about the compound, such as its molecular structure, properties, and associated bioactivities.
Using a common name for searching can simplify the process, especially when the numerical identifiers are not known. However, because a name can map to multiple records, the results might need further filtering or validation to ensure they correspond to the specific compound of interest.
3. By Structure Identity: Another method to specify a compound in PubChem PUG REST API requests is by using structural identifiers such as SMILES or InChI keys. This approach allows for precise identification of chemical structures by providing a textual representation of the molecule. For example, to retrieve the CID for the SMILES string “CCCC” (which represents butane), you can use the following code:
result <- get_pug_rest(identifier = "CCCC", namespace = "smiles", domain = "compound", operation = "cids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: SMILES
#> - Operation: cids
#> - Identifier: CCCC
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.When the pubChemData(result) function is executed, it retrieves the output in data frame. The output indicates that the search for the SMILES string “CCCC” returned a single CID:
pubChemData(result)
#> Text
#> 1 7843This output reveals that the SMILES string “CCCC” corresponds to the CID 7843. This CID can then be used in further queries to gather detailed information about the compound, such as its molecular structure, physical and chemical properties, biological activities, and more.
Using structure-based identifiers like SMILES or InChI keys is particularly useful for precise and unambiguous chemical searches, as these identifiers provide a detailed representation of the molecule’s structure. This method ensures that the exact compound of interest is identified, reducing the risk of ambiguity that might arise with common names or other identifiers.
4. By Fast (Synchronous) Structure Search: In PubChem PUG REST API, fast (synchronous) structure search allows for quicker searches by identity, similarity, substructure, and superstructure, often returning results in a single call. This method is efficient for obtaining results quickly and is useful for various types of structural queries.
To illustrate, let’s perform a fast identity search for the compound with CID 5793, using the same connectivity option:
result <- get_pug_rest(identifier = "5793", namespace = "cid", domain = "compound", operation = "cids", output = "TXT", searchtype = "fastidentity", options = list(identity_type = "same_connectivity"))
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: CID
#> - Operation: cids
#> - Identifier: 5793
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.When the following code executed, it retrieves the output in data frame, listing all CIDs that match the fast identity search criteria.
pubChemData(result)
#> Text
#> 1 5793
#> 2 206
#> 3 6036
#> 4 18950
#> 5 64689
#> 6 66371
#> 7 79025
#> 8 81696
#> 9 104724
#> 10 185698
#> 11 439353
#> 12 439357
#> 13 439507
#> 14 439583
#> 15 439680
#> 16 441032
#> 17 441033
#> 18 441034
#> 19 441035
#> 20 444314
#> 21 448388
#> 22 448702
#> 23 451187
#> 24 451188
#> 25 451189
#> 26 452245
#> 27 455147
#> 28 657055
#> 29 1549080
#> 30 2724488
#> 31 3000450
#> 32 3034742
#> 33 5319264
#> 34 6102790
#> 35 6321330
#> 36 6323336
#> 37 6400264
#> 38 6560213
#> 39 6971003
#> 40 6971007
#> 41 6971016
#> 42 6971096
#> 43 6971097
#> 44 6971098
#> 45 6992021
#> 46 6992084
#> 47 7018164
#> 48 7043897
#> 49 7044038
#> 50 7098663
#> 51 7098664
#> 52 7157007
#> 53 9794056
#> 54 9815418
#> 55 9834129
#> 56 9899007
#> 57 10035228
#> 58 10081060
#> 59 10103794
#> 60 10130220
#> 61 10197954
#> 62 10219674
#> 63 10219763
#> 64 10313382
#> 65 10329946
#> 66 10899282
#> 67 10954241
#> 68 11019447
#> 69 11030410
#> 70 11344362
#> 71 11367383
#> 72 11412863
#> 73 11480819
#> 74 11492034
#> 75 11571906
#> 76 11571917
#> 77 11600783
#> 78 11651921
#> 79 11672764
#> 80 11959770
#> 81 11970126
#> 82 12003287
#> 83 12193653
#> 84 12285853
#> 85 12285856
#> 86 12285861
#> 87 12285862
#> 88 12285863
#> 89 12285866
#> 90 12285868
#> 91 12285869
#> 92 12285870
#> 93 12285871
#> 94 12285873
#> 95 12285877
#> 96 12285878
#> 97 12285879
#> 98 12285885
#> 99 12285886
#> 100 12285889
#> 101 12285890
#> 102 12285891
#> 103 12285892
#> 104 12285893
#> 105 12285894
#> 106 16054987
#> 107 16211884
#> 108 16211941
#> 109 16211984
#> 110 16211986
#> 111 16212959
#> 112 16212960
#> 113 16212966
#> 114 16213546
#> 115 16213640
#> 116 16213872
#> 117 16217112
#> 118 16219580
#> 119 21355827
#> 120 22825318
#> 121 22836365
#> 122 22836366
#> 123 23424086
#> 124 24728695
#> 125 24802149
#> 126 24802163
#> 127 24802281
#> 128 24892722
#> 129 42626680
#> 130 44328781
#> 131 44328785
#> 132 46188479
#> 133 46780441
#> 134 46897877
#> 135 50939543
#> 136 51340651
#> 137 54445181
#> 138 54445182
#> 139 56845432
#> 140 56845995
#> 141 57197748
#> 142 57288387
#> 143 57483528
#> 144 57691826
#> 145 57973135
#> 146 58070804
#> 147 58265153
#> 148 58265160
#> 149 58265166
#> 150 58265178
#> 151 58265190
#> 152 58265196
#> 153 58300638
#> 154 58594768
#> 155 58595959
#> 156 58618581
#> 157 58969552
#> 158 59034276
#> 159 59036328
#> 160 59040622
#> 161 59083882
#> 162 59105109
#> 163 59125088
#> 164 59146659
#> 165 59383280
#> 166 59445439
#> 167 59503407
#> 168 59503411
#> 169 59886072
#> 170 59965103
#> 171 60052896
#> 172 60078648
#> 173 66629908
#> 174 67518639
#> 175 67615000
#> 176 67615455
#> 177 67641738
#> 178 67938791
#> 179 67944215
#> 180 67944290
#> 181 67950444
#> 182 68167579
#> 183 68324677
#> 184 68334110
#> 185 69528681
#> 186 70443535
#> 187 70543261
#> 188 71309028
#> 189 71309128
#> 190 71309129
#> 191 71309140
#> 192 71309397
#> 193 71309503
#> 194 71309513
#> 195 71309514
#> 196 71309671
#> 197 71309852
#> 198 71309905
#> 199 71309908
#> 200 71309927
#> 201 71317094
#> 202 71317095
#> 203 71317096
#> 204 71317097
#> 205 71317182
#> 206 71777654
#> 207 75357255
#> 208 76973265
#> 209 86278404
#> 210 87297824
#> 211 87929779
#> 212 87931119
#> 213 88255060
#> 214 88547603
#> 215 88974141
#> 216 89000581
#> 217 89200515
#> 218 89332529
#> 219 89374440
#> 220 89424182
#> 221 89742272
#> 222 89855666
#> 223 90057933
#> 224 90159939
#> 225 90346255
#> 226 90470917
#> 227 90472751
#> 228 90472752
#> 229 90472753
#> 230 90472761
#> 231 90472762
#> 232 90472770
#> 233 90473076
#> 234 90781811
#> 235 90895196
#> 236 91057721
#> 237 92043367
#> 238 92043446
#> 239 101015849
#> 240 101033892
#> 241 101254308
#> 242 101254309
#> 243 101254310
#> 244 101254311
#> 245 101254312
#> 246 101254313
#> 247 101254314
#> 248 101254315
#> 249 101469918
#> 250 101513786
#> 251 101718250
#> 252 101718251
#> 253 101796201
#> 254 102089288
#> 255 102447462
#> 256 102447463
#> 257 102601142
#> 258 102601177
#> 259 102601371
#> 260 102601743
#> 261 102601816
#> 262 117064633
#> 263 117064644
#> 264 117065485
#> 265 117633116
#> 266 117768413
#> 267 117938207
#> 268 118797420
#> 269 118797610
#> 270 118797621
#> 271 118797622
#> 272 118855887
#> 273 118855889
#> 274 118855904
#> 275 118855910
#> 276 118855920
#> 277 118855925
#> 278 118924468
#> 279 121494046
#> 280 121494058
#> 281 122360911
#> 282 122522140
#> 283 125309563
#> 284 125353406
#> 285 126704391
#> 286 129629038
#> 287 131698424
#> 288 131698425
#> 289 131698450
#> 290 131699179
#> 291 131842051
#> 292 131966764
#> 293 132939819
#> 294 132939820
#> 295 133119158
#> 296 133119249
#> 297 133121364
#> 298 133662560
#> 299 133662561
#> 300 133662562
#> 301 134695353
#> 302 134860471
#> 303 136898365
#> 304 137554722
#> 305 139025182
#> 306 140565377
#> 307 141697522
#> 308 142119910
#> 309 145874935
#> 310 153238571
#> 311 153238579
#> 312 154008122
#> 313 154724068
#> 314 155920671
#> 315 156615593
#> 316 162642814
#> 317 166450901
#> 318 166606713
#> 319 168357285
#> 320 168358828
#> 321 168361185
#> 322 168361364
#> 323 168361934
#> 324 168362043
#> 325 168363258
#> 326 168364204
#> 327 168365395
#> 328 168365574
#> 329 168366670
#> 330 168371870
#> 331 168372103
#> 332 168375045
#> 333 168375837
#> 334 168375921
#> 335 169440996
#> 336 169440997
#> 337 169493886
#> 338 169493887
#> 339 169494552The output indicates that there are numerous compounds with similar connectivity to the compound identified by CID 5793. Each row in the output represents a different CID that shares the same connectivity pattern as the original compound. This extensive list includes hundreds of CIDs, showcasing the effectiveness of the fast identity search in identifying structurally related compounds quickly.
This method is advantageous for researchers needing to identify compounds with similar structures for further study, such as drug development, chemical analysis, or bioactivity screening. The fast response time and comprehensive results make it a valuable tool for various chemical and pharmaceutical applications.
5. By Cross-Reference (XRef): The cross-reference (XRef) method allows for reverse lookup of records using a cross-reference value. This method is particularly useful for linking external identifiers, such as patent numbers, to records in the PubChem database. For example, to find all SIDs linked to a specific patent identifier, you can use the following code:
result <- get_pug_rest(identifier = "US20050159403A1", namespace = "xref/PatentID", domain = "substance", operation = "sids", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Substance
#> - Namespace: DomainSpecific
#> - Operation: sids
#> - Identifier: US20050159403A1
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData function retrieves all SIDs that are linked to the specified patent identifier. The output indicates that the specified patent identifier “US20050159403A1” is linked to a large number of SIDs. Each SID represents a different substance that has been referenced in the patent.
pubChemData(result)
#> $IdentifierList
#> $IdentifierList$SID
#> [1] 127377127 127382334 127386382 127387376 127394906 127397376 127401897
#> [8] 127417654 127421022 127427561 127429426 127432264 127440404 127440428
#> [15] 127445646 127449926 127457867 127460434 127463574 127464134 127494894
#> [22] 127496937 127498548 127529998 127543991 127546018 127550965 127560184
#> [29] 127566278 127568614 127579066 127599056 127600815 127611817 127623534
#> [36] 127625503 127632433 127671807 127679107 127688846 127691718 127697988
#> [43] 127711332 127715174 127721611 127722233 127724090 127724974 127727269
#> [50] 127740859 127774458 127786062 127790664 127793921 127794507 127795243
#> [57] 127815192 127824113 127825299 127832880 127835824 127841389 127851147
#> [64] 127855878 127884538 127887083 127907515 127915891 127918344 127926702
#> [71] 127931871 127943403 127949193 127959361 127959362 127961945 127968700
#> [78] 127974435 127988890 128003687 128016428 128024305 128030061 128033308
#> [85] 128033392 128037075 128041901 128043208 128054804 128071903 128075872
#> [92] 128078936 128080424 128086739 128096360 128107971 128108063 128108066
#> [99] 128112623 128116501 128122481 128133149 128139949 128147430 128149266
#> [106] 128164707 128171553 128181006 128199891 128202584 128204869 128208747
#> [113] 128209556 128214152 128216313 128231608 128233622 128235075 128239224
#> [120] 128247683 128253922 128254582 128257870 128265053 128273912 128287030
#> [127] 128289228 128292761 128310374 128310447 128311517 128313782 128319875
#> [134] 128321254 128324845 128327185 128328645 128338633 128344584 128358565
#> [141] 128360063 128361597 128370060 128375029 128381421 128383506 128383593
#> [148] 128385126 128390596 128391357 128391640 128397827 128407104 128414752
#> [155] 128417831 128417970 128421724 128427165 128429151 128431035 128453144
#> [162] 128454426 128459192 128479099 128485819 128490532 128490533 128496172
#> [169] 128504855 128514984 128515903 128531133 128539521 128548161 128550853
#> [176] 128555702 128571383 128573137 128579725 128582246 128587585 128600655
#> [183] 128620771 128624545 128627105 128628584 128632557 128632828 128633726
#> [190] 128633902 128634258 128639692 128642692 128646882 128649366 128675326
#> [197] 128675957 128689052 128690685 128693396 128694828 128699310 128702849
#> [204] 128706476 128716066 128720357 128723298 128723509 128731938 128749024
#> [211] 128749163 128751829 128757815 128766098 128776154 128783768 128789021
#> [218] 128789967 128791547 128796670 128801133 128801849 128804888 128804889
#> [225] 128808454 128815642 128821150 128833107 128837247 128846910 128856633
#> [232] 128862719 128865088 128873754 128874253 128880985 128881190 128894056
#> [239] 128894682 128905743 128908713 128915047 128915536 128921696 128931918
#> [246] 128934857 128935768 128953776 128955396 128970283 128981506 128988380
#> [253] 128997690 129001067 129007663 129014483 129015035 129015817 129016179
#> [260] 129017989 129017990 129026427 129044226 129053129 129054986 129068688
#> [267] 129068801 129079556 129084855 129102578 129104885 129111825 129113828
#> [274] 129115030 129122432 129128697 129130686 129133094 129136176 129140081
#> [281] 129141617 129142896 129148181 129162993 129168398 129173408 129173457
#> [288] 129176810 129177288 129184645 129192608 129202881 129203714 129205760
#> [295] 129209673 129218442 129224837 129228814 129233871 129233873 129233874
#> [302] 129255832 129266266 129272170 129288442 129292073 129294634 129302252
#> [309] 129309716 129310311 129313799 129317146 129328896 129333065 129337106
#> [316] 129337589 129345232 129349967 129351897 129359174 129365621 129366270
#> [323] 129370686 129371805 129374061 129376455 129378267 129379472 129383430
#> [330] 129384458 129389744 129403822 129421538 129440903 129455218 129456175
#> [337] 129457573 129462203 129479103 129489229 129493774 129504746 129508593
#> [344] 129517263 129521307 129526420 129534168 129538802 129547789 129551052
#> [351] 129551258 129555666 129562150 129573817 129586364 129598381 129614967
#> [358] 129617515 129624957 129625178 129625510 129627772 129627879 129629301
#> [365] 129632951 129670298 129672175 129685831 129688258 129702886 129706999
#> [372] 129709395 129711942 129715311 129726350 129728891 129729719 129736495
#> [379] 129738647 129764614 129770055 129776398 129781417 129797152 129808214
#> [386] 129809046 129809280 129811709 129815623 129815624 129818107 129838999
#> [393] 129842321 129844561 129845709 129855419 129865464 129871639 129873187
#> [400] 129873949 129879637 129880907 129894085 129894756 129894757 129906668
#> [407] 129908561 129912020 129921074 129935955 129936330 129941294 129945069
#> [414] 129950653 129962601 129975648 134359275 134393961 134412235 135747269
#> [421] 135752889 135754219 135763149 135798297 135802614 135806152 135826617
#> [428] 135837077 135842328 135847369 135857922 135878265 135887484 135892282
#> [435] 135900333 135900801 135946050 135971530 136022349 136022812 136044641
#> [442] 136052383 136057158 136072993 136080169 136099624 136116271 136118214
#> [449] 136126969 136156103 136157629 136161084 136172216 136222651 136227638
#> [456] 136234395 136261580 136265581 136269831 136272977 136273523 136275074
#> [463] 136291195 136291391 136302881 136314053 136324561 136326756 137349406
#> [470] 137349415 139042442 139667196 140037191 140037194 140254002 140254003
#> [477] 140254004 140254005 140254006 140254007 140254008 140254009 140254010
#> [484] 140254011 140254012 140254013 140254014 140254015 140254016 140254017
#> [491] 140254018 140254019 140254020 140254021 140254022 140254023 140254024
#> [498] 140254025 140254026 140254027 140254028 140254029 140254030 140254031
#> [505] 140254032 140254033 140254034 140254035 140254036 140254037 140254038
#> [512] 140254039 140254040 140254041 140254042 140254043 140254044 140254045
#> [519] 140254046 140254047 140254048 140254049 140254050 140254051 140254052
#> [526] 140254053 140254054 140254055 140254056 140254057 140254058 140254059
#> [533] 140254060 140254061 140254062 140254063 140254064 140254065 140254066
#> [540] 140254067 140254068 140254069 140254070 140254071 140254072 140254073
#> [547] 140254074 140254075 140254076 140254077 140254078 140254079 140254080
#> [554] 140254081 140254082 140254083 140254084 140254085 140254086 140254087
#> [561] 140254088 140254089 140254090 140254091 140254092 140254093 140254094
#> [568] 140254095 140254096 140254097 140254098 140254099 140254100 140262425
#> [575] 140262449 140262456 140262460 140262471 140262478 140262480 140262481
#> [582] 140262486 140262491 140262504 140297441 140297443 140343485 140343488
#> [589] 140343490 140343491 140343493 140343497 140343499 140343505 140492225
#> [596] 141972099 141972100 141989468 142047558 142047559 142059950 142086609
#> [603] 142090637 142093192 142106350 142106351 142106355 142106365 142106373
#> [610] 142130212 142216111 142266779 142289307 142290035 142292362 142292867
#> [617] 142300477 142301161 142355996 142359434 142359441 142365242 142395042
#> [624] 142395064 142396928 142396930 142396931 142398573 142405238 142418631
#> [631] 142438154 142448656 142456985 142456989 142456990 142456991 142456995
#> [638] 142457001 142457025 142457027 142457031 142457036 142457040 142457045
#> [645] 142457053 142457055 142457058 142457059 142457063 142457067 142457072
#> [652] 142457075 142457076 142457077 142457082 142457086 142457092 142457095
#> [659] 142457098 142457099 142457106 142457115 142457119 142457130 142457134
#> [666] 142457138 142457141 142457144 142457146 142457150 142457151 142457164
#> [673] 142457170 142457176 142457178 142457181 142457183 142457188 142457195
#> [680] 142457199 142457201 142457202 142457210 142457212 142457213 142457217
#> [687] 142472709 142504653 142517754 142718650 142794296 142794297 142794298
#> [694] 142976674 142976694 143004316 143078051 143078053 143078054 143078056
#> [701] 143078060 143078078 143078326 143091452 143251864 143251865 143251867
#> [708] 143251868 143251869 143251871 143251875 143251881 143251883 143251885
#> [715] 143251886 143251887 143251888 143251890 143251892 143251894 143251895
#> [722] 143274528 143298830 143319100 226393239 226393293 226393570 226393684
#> [729] 226393819 226393829 226393830 226393853 226393858 226393970 226393971
#> [736] 226394040 226394128 226394161 226394178 226394363 226394438 226394481
#> [743] 226394721 226394839 226395300 226395327 226395471 226395557 226395600
#> [750] 226395667 226395683 226395726 226395777 226395791 226395832 226395919
#> [757] 226395920 226395976 226395977 226396049 226396167 226396198 226396401
#> [764] 226396434 226396445 226396464 226396553 226396598 226396617 226396621
#> [771] 226396627 226397203 226397214 226397352 226397529 226397954 226397955
#> [778] 226398150 226398151 226398302 226398454 226399315 226399316 226399355
#> [785] 226399517 226399539 226399589 226400026 226400044 226400188 226400189
#> [792] 226400247 226400424 226401770 226402238 226405416 226405489 226405836
#> [799] 226406284 226406322 226406323 226406337 226406377 226406378 226406714
#> [806] 226406715 226406888 226407848 226408395 226408853 226409030 226409597
#> [813] 226409697 226410719 226411068 226411348 226411370 226411403 226411806
#> [820] 226412544 226412844 226412845 226412937 226413104 226413385 226413386
#> [827] 226413604 226413605 226413606 226414206 226414262 226414263 226414297
#> [834] 226414324 226419993 226419994 226420042 226420160 226420161 226420292
#> [841] 226420293 226420456 226420457 226420566 226420567 226420640 226420681
#> [848] 226420720 226420751 226420773 226420774 226420775 226420787 226420804
#> [855] 226420877 226421001 226421002 226421003 226421699 226421728 226423326
#> [862] 226423740 226423826 226424221 226424268 226424269 226424411 226424412
#> [869] 226424915 226425111 226425112 226425266 226425785 226425786 226425915
#> [876] 226425916 226426085 226426288 226426344 226426345 226426582 226426623
#> [883] 226426904 226427860 226427861 226428721 226428722 226428885 226429123
#> [890] 226429124 226432865 226432866 226433067 226433069 226433070 226433090
#> [897] 226433091 226433125 226433126 226433141 226433192 226433193 226433202
#> [904] 226433203 226433344 226433345 226433523 226433524 226433876 226434160
#> [911] 226434771 226440330 226441562 226443823 226445144 226457181 226457266
#> [918] 226457330 226457331 226457556 226458114 226458225 226458539 226459695
#> [925] 226461214 226462543 226471608 226471621 226472159 226472161 226487293
#> [932] 226487863 226487864 226489321 226490310 226490791 226492265 226492375
#> [939] 226492435 226492437 226492438 226493640 226494285 226494502 226495017
#> [946] 226495025 226497342 226503391 226503607 226506442 226506563 226516040
#> [953] 226520272 226521124 226542800 226553920 226554136 226564914 226567033
#> [960] 226567034 226567043 226567109 226567110 226567180 226567194 226567379
#> [967] 226567380 226567400 226567435 226567443 226567450 226567458 226567459
#> [974] 226567556 226567567 226567574 226567579 226567629 226567646 226567656
#> [981] 226567670 226567681 226567699 226567701 226567702 226567706 226567717
#> [988] 226567727 226567759 226567799 226567800 226567820 226567824 226567833
#> [995] 226567848 226567862 226567886 226567894 226567923 226567935 226567950
#> [1002] 226567961 226567989 226568036 226568060 226568061 226568066 226568082
#> [1009] 226568123 226568127 226568139 226568146 226568177 226568234 226568241
#> [1016] 226568245 226568264 226568294 226568315 226568346 226568349 226568359
#> [1023] 226568362 226568364 226568408 226568416 226568417 226568432 226568449
#> [1030] 226568457 226568460 226568463 226568464 226568465 226568530 226568537
#> [1037] 226568633 226568641 226568645 226568657 226568663 226568670 226568680
#> [1044] 226568696 226568699 226568700 226568701 226568711 226568713 226568725
#> [1051] 226568734 226568738 226568746 226568772 226568798 226568876 226568911
#> [1058] 226568928 226568929 226568941 226568980 226569025 226569064 226569099
#> [1065] 226569118 226569177 226569196 226569204 226569217 226569220 226569226
#> [1072] 226569232 226569328 226569330 226569349 226569414 226569437 226569451
#> [1079] 226569464 226569471 226569516 226569535 226569554 226569573 226569593
#> [1086] 226569594 226569596 226569607 226569623 226569624 226569625 226569648
#> [1093] 226569680 226569683 226569748 226569754 226569769 226569783 226569821
#> [1100] 226569829 226569832 226569836 226569850 226569859 226569892 226569907
#> [1107] 226569908 226569912 226569959 226569976 226569984 226569988 226570060
#> [1114] 226570099 226570146 226570279 226570308 226570330 226570331 226570363
#> [1121] 226570382 226570383 226570483 226570745 226570749 226570755 226570849
#> [1128] 226571011 226573101 226573345 226574052 226574439 226582522 226584018
#> [1135] 226589272 226589273 226597434 226597505 226600715 226600746 226647066
#> [1142] 226648068 226656069 226667895 226668614 226668738 226668855 226669423
#> [1149] 226669639 226670087 226683506 226696380 226710719 226823612 226871249
#> [1156] 226876459 226876460 226936194 226965286 226972501 226973045 226973164
#> [1163] 227122429 227236737 227281952 227325851 227339001 227384742 227409508
#> [1170] 227461168 227461872 227474526 227511968 227511969 227564952 227748570
#> [1177] 227960305 227987782 227988458 227990171 227990458 227991140 228067840
#> [1184] 228093688 228094302 228094400 228094598 228099363 228140626 228159764
#> [1191] 228159766 228248383 228248928 228263743 228265260 228304181 228304246
#> [1198] 228355922 228361147 228452780 228639103 228770559 228770560 228819438
#> [1205] 228821051 228821054 228821055 228821056 228821057 228821058 228821059
#> [1212] 229280318 229294930 229334353 229337219 229634546 230157026 230160664
#> [1219] 230162107 230331623 230331934 230335306 230336805 230336809 230337506
#> [1226] 230337861 230338660 230338865 230922657 231379826 231380229 231380490
#> [1233] 231380595 231408598 231804558 231804593 231804765 231805001 231805228
#> [1240] 231805267 231805479 231805547 231805598 231805601 231805607 232099662
#> [1247] 232168843 242681556 242717650 242881388 242920991 242939316 243086546
#> [1254] 243093644 243247276 243279817 243310463 243530634 243738751 243781361
#> [1261] 243836721 244274765 244304819 244351778 244473144 244482943 244615862
#> [1268] 244627129 244636869 244759771 244861749 245029031 245033760 245283852
#> [1275] 245309404 245363541 245370020 245708899 245712680 245833937 245910951
#> [1282] 246055152 246059618 246152086 246185335 246302557 246328178 246352373
#> [1289] 246554028 246643596 246771767 246837580 246918682 246999746 247221074
#> [1296] 247555200 247576141 247608871 247940116 248042834 248050678 248370740
#> [1303] 248382919 248412763 248454658 248521494 248564737 248603625 248633503
#> [1310] 248880456 248936405 248962580 249096157 406908050 406924010 406974008
#> [1317] 407050344 407246776 407400630 407406725 407454637 407458795 407597864
#> [1324] 407694713 408147735 408215224 408217559 408259874 408364713 408470213
#> [1331] 408624647 408901036 409227565 409282571 409314082 409433585 409471800
#> [1338] 409673423 409688950 409807984 409808036 409844257 409847976 409898992
#> [1345] 409899538 409899617 409900700 409918668 409918859 409956750 410076269
#> [1352] 410111933 410112156 410199016 410250219 410310907 410320935 410358412
#> [1359] 410358870 410358993 410364139 410368205 410390548 410443241 410611603
#> [1366] 410656308 410714557 410730470 410800662 410813610 410878039 410889153
#> [1373] 411029050 411120346 411209812 411236714 411322314 411481111 411739633
#> [1380] 411848723 412068746 412190947 412223907 412476987 412478856 412516310
#> [1387] 412540966 412700950 412759940 412769395 412771380 412892589 413247619
#> [1394] 413431688 413450070 413450927 413457356 413457635 413458038 413458045
#> [1401] 413478250 413485032 413490608 413490982 413505830 413505848 413505864
#> [1408] 413505881 413515875 413516940 413517191 413517594 413517711 413517787
#> [1415] 413518248 413518286 413518452 413555803 413573934 413576342 413577607
#> [1422] 413578969 413583708 413584099 413596608 413598583 413598590 413647181
#> [1429] 413911986 413963852 414064183 414626516 414661397 414825813 414856510
#> [1436] 414892091 414935619 414945852 414956160 415069749 415110648 415136092
#> [1443] 415714536 415727884 415728598 415729189 415729254 415729316 415732559
#> [1450] 415732675 415732908 415732945 415732955 415732961 415732979 415733001
#> [1457] 415733004 415740875 415748816 415748861 415748865 415748910 415749238
#> [1464] 415749262 415749353 415750692 415812290 415816885 415821932 415824540
#> [1471] 415827755 415827762 415828559 415829165 415830681 415835565 415850432
#> [1478] 415850705 415851694 415853441 415855021 415857010 415859316 415871129
#> [1485] 415872890 415873239 415875742 415939267 415966755 415966911 415967507
#> [1492] 416129933 416132545 419476058 419476730 419479763 419480873 419480972
#> [1499] 419485881 419486666 419490957 419491152 419491791 419492671 419492675
#> [1506] 419492924 419493503 419494003 419494133 419494704 419495016 419495902
#> [1513] 419495947 419496295 419497698 419497700 419497832 419499306 419499403
#> [1520] 419499559 419499585 419499632 419499643 419499837 419499846 419499949
#> [1527] 419500086 419500181 419500734 419500914 419501182 419501547 419501734
#> [1534] 419502131 419502930 419503347 419503687 419503883 419503967 419504952
#> [1541] 419505428 419506158 419506282 419506849 419507096 419507450 419507595
#> [1548] 419510089 419512824 419513193 419513201 419513968 419514082 419514092
#> [1555] 419514098 419514102 419514108 419514115 419514117 419516874 419523755
#> [1562] 419524130 419524875 419525381 419526621 419527521 419531719 419531724
#> [1569] 419531750 419531947 419532553 419532839 419534378 419534410 419534469
#> [1576] 419534484 419535046 419535071 419535113 419536034 419536121 419546112
#> [1583] 419549332 419551105 419551195 419551405 419551879 419551899 419551910
#> [1590] 419552498 419553075 419553096 419553297 419554682 419555018 419555613
#> [1597] 419555769 419557728 419559147 419559194 419559505 419561476 419572553
#> [1604] 419574667 419574686 419578517 419585247 419590036 419590658 419590946
#> [1611] 419591129 419591195 419591612 419592226 419593794 419595719 419681507
#> [1618] 419682519 419690476 419700929 419701108 419705795 419714072 419714186
#> [1625] 419721779 419722600 419724974 419742001 419765198 419765456 419968009
#> [1632] 420012827 420028738 420028752 420028796 420028825 420121099 420132130
#> [1639] 420290406 420482162 420509561 420599383 420599583 420611634 420613278
#> [1646] 420625825 420634933 420662981 420668293 420713373 420762856 420764388
#> [1653] 421051216 421054472 421152487 421168189 421185220 421200485 421285150
#> [1660] 421467012 421467021 421467167 421467814 421467821 421467841 421468181
#> [1667] 421618729 421645675 422224723 422286156 422291469 422291508 422291541
#> [1674] 422291868 422294992 422295060 422302674 422302967 422308315 422308547
#> [1681] 422309266 422309809 422319370 422361298 422394972 422395317 422395612
#> [1688] 422397162 422397173 422397290 422423005 422425739 422425747 422425769
#> [1695] 422478595 422511204 422511386 422536544 422536551 422537057 422537069
#> [1702] 422537094 422537110 422537118 422550741 422568394 422568403 422571327
#> [1709] 422571343 422571354 422571402 422573560 422573909 423390419 424119783
#> [1716] 424296317 424306124 424306736 424309010 424309022 424757743 424766567
#> [1723] 424766737 424803005 424818908 424819603 424819823 424819832 424849043
#> [1730] 424877080 425113081 425114186 425165937 425171162 425193155 425312104
#> [1737] 425396324 425516770 425535208 425897534 425961463 425965903 425967206
#> [1744] 426045728 426078961 426089733 426103724 426106692 426108038 426109622
#> [1751] 426110449 426119983 426121923 426147338 426149755 426150549 426150787
#> [1758] 426157394 426159592 426272317 426288672 426294028 426310077 426324267
#> [1765] 426359948 426412333 426432571 426442188 426459973 426517444 427700056
#> [1772] 431577953 432891950 433323349 433323597 433567908 447595048 447853768
#> [1779] 447923060 448050232 448532098 448892836 449326453 449676699 449681106
#> [1786] 449910701 450051033 450232513 450235101 450485725 450532993 450630545
#> [1793] 450682277 451013988 451180599 451555494 451961792 452145594 452311423
#> [1800] 452516785 452986205 453242316 453516563 453664627 453678106 453867505
#> [1807] 453889148 454241035 454274907 454483135 454611257 454631768 456171974
#> [1814] 456295911 456370357 456371022 456411915 456468049 456636612 456671281
#> [1821] 456739466 456796473 456977526 457169682 457192620 457203572 457280508
#> [1828] 457282502 457310819 457311044 457459970 457460012 457584123 457655803
#> [1835] 457673794 457673796 457815268 457842244 458157987 458347242 458392451
#> [1842] 458393276 458393605 458393636 458393652 458393705 458393708 458393785
#> [1849] 458393799 458393801 458394569 458394830 458394859 458394861 458395827
#> [1856] 458396401 458396411 458396423 458397310 458397365 458427722 466349722
#> [1863] 482532917This result provides a comprehensive list of substances associated with the specified patent, allowing for further exploration and analysis within the PubChem database.
Once you’ve specified the records of interest in PUG REST, the next step is to define what information you want to retrieve about these records. PUG REST excels in providing access to specific data points about each record, such as individual properties or cross-references, without the need to download and sift through large datasets.
1. Full Records: PUG REST allows the retrieval of entire records in various formats like JSON, CSV, TXT, and SDF. For example, to retrieve the record for aspirin (CID 2244) in SDF format:
result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", output = "SDF")Multiple records can also be requested in a single call, though large lists may be subject to timeouts.
2. Images: Images of chemical structures can be retrieved by specifying PNG format. This works with various input methods, including chemical names, SMILES strings, and InChI keys. For example, to get an image for the chemical name “lipitor”:
get_pug_rest(identifier = "lipitor", namespace = "name", domain = "compound", output = "PNG")
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: Name
#> - Operation: <NULL>
#> - Identifier: lipitor
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.3. Compound Properties: Pre-computed properties for PubChem compounds are accessible individually or in tables. For instance, to get the molecular weight of a compound:
result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", property = "MolecularWeight", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: CID
#> - Operation: <NULL>
#> - Identifier: 2244
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 180.16Or to retrieve a CSV table of multiple compounds and properties:
result <- get_pug_rest(identifier = c("1","2","3","4","5"), namespace = "cid", domain = "compound", property = c("MolecularWeight", "MolecularFormula", "HBondDonorCount", "HBondAcceptorCount", "InChIKey", "InChI"), output = "CSV")pubChemData(result)
#> CID MolecularWeight MolecularFormula HBondDonorCount HBondAcceptorCount
#> 1 1 203.24 C9H17NO4 0 4
#> 2 2 204.24 C9H18NO4+ 1 4
#> 3 3 156.14 C7H8O4 3 4
#> 4 4 75.11 C3H9NO 2 2
#> 5 5 169.07 C3H8NO5P 3 6
#> InChIKey
#> 1 RDHQFKQIGNGIED-UHFFFAOYSA-N
#> 2 RDHQFKQIGNGIED-UHFFFAOYSA-O
#> 3 INCSWYKICIYAHB-UHFFFAOYSA-N
#> 4 HXKKHQJGJAFBHI-UHFFFAOYSA-N
#> 5 HIQNVODXENYOFK-UHFFFAOYSA-N
#> InChI
#> 1 InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3
#> 2 InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/p+1
#> 3 InChI=1S/C7H8O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,5-6,8-9H,(H,10,11)
#> 4 InChI=1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3
#> 5 InChI=1S/C3H8NO5P/c4-1-3(5)2-9-10(6,7)8/h1-2,4H2,(H2,6,7,8)4. Synonyms: To view all synonyms of a compound, such as Vioxx:
result <- get_pug_rest(identifier = "vioxx", namespace = "name", domain = "compound", operation = "synonyms", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: Name
#> - Operation: synonyms
#> - Identifier: vioxx
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $InformationList
#> $InformationList$Information
#> $InformationList$Information[[1]]
#> $InformationList$Information[[1]]$CID
#> [1] 5090
#>
#> $InformationList$Information[[1]]$Synonym
#> [1] "rofecoxib"
#> [2] "162011-90-7"
#> [3] "Vioxx"
#> [4] "Ceoxx"
#> [5] "MK 966"
#> [6] "4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one"
#> [7] "refecoxib"
#> [8] "Vioxx Dolor"
#> [9] "MK-966"
#> [10] "4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one"
#> [11] "MK0966"
#> [12] "4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone"
#> [13] "MK 0966"
#> [14] "MK-0966"
#> [15] "rofecoxibum"
#> [16] "CCRIS 8967"
#> [17] "HSDB 7262"
#> [18] "TRM-201"
#> [19] "UNII-0QTW8Z7MCR"
#> [20] "0QTW8Z7MCR"
#> [21] "3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one"
#> [22] "2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-"
#> [23] "NSC-720256"
#> [24] "NSC-758705"
#> [25] "CHEBI:8887"
#> [26] "DTXSID2023567"
#> [27] "M01AH02"
#> [28] "MK966"
#> [29] "3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone"
#> [30] "4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone"
#> [31] "4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone"
#> [32] "3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone"
#> [33] "4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one"
#> [34] "CHEMBL122"
#> [35] "4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one"
#> [36] "DTXCID903567"
#> [37] "TRM201"
#> [38] "NSC720256"
#> [39] "NSC 720256"
#> [40] "NSC 758705"
#> [41] "2(5H)-Furanone, 4-(4-(methylsulfonyl)phenyl)-3-phenyl-"
#> [42] "NCGC00095118-01"
#> [43] "ROFECOXIB (MART.)"
#> [44] "ROFECOXIB [MART.]"
#> [45] "Vioxx (trademark)"
#> [46] "SMR000466331"
#> [47] "Vioxx (TN)"
#> [48] "SR-01000762904"
#> [49] "3-phenyl-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone"
#> [50] "Rofecoxib (JAN/USAN/INN)"
#> [51] "Rofecoxib [USAN:INN:BAN]"
#> [52] "Rofecoxib (Vioxx)"
#> [53] "Rofecoxib [USAN]"
#> [54] "MFCD00935806"
#> [55] "KS-1107"
#> [56] "MK 0996"
#> [57] "Spectrum_000119"
#> [58] "ROFECOXIB [INN]"
#> [59] "ROFECOXIB [JAN]"
#> [60] "SpecPlus_000669"
#> [61] "ROFECOXIB [MI]"
#> [62] "ROFECOXIB [HSDB]"
#> [63] "Spectrum2_000446"
#> [64] "Spectrum3_001153"
#> [65] "Spectrum4_000631"
#> [66] "Spectrum5_001598"
#> [67] "ROFECOXIB [VANDF]"
#> [68] "ROFECOXIB [WHO-DD]"
#> [69] "SCHEMBL3050"
#> [70] "BSPBio_002705"
#> [71] "KBioGR_001242"
#> [72] "KBioGR_002345"
#> [73] "KBioSS_000559"
#> [74] "KBioSS_002348"
#> [75] "MLS000759440"
#> [76] "MLS001165770"
#> [77] "MLS001195623"
#> [78] "MLS001424113"
#> [79] "MLS006010091"
#> [80] "BIDD:GT0399"
#> [81] "DivK1c_006765"
#> [82] "SPECTRUM1504235"
#> [83] "SPBio_000492"
#> [84] "3-(4-methanesulfonylphenyl)-2-phenyl-2-buten-4-olide"
#> [85] "GTPL2893"
#> [86] "ROFECOXIB [ORANGE BOOK]"
#> [87] "BDBM22369"
#> [88] "KBio1_001709"
#> [89] "KBio2_000559"
#> [90] "KBio2_002345"
#> [91] "KBio2_003127"
#> [92] "KBio2_004913"
#> [93] "KBio2_005695"
#> [94] "KBio2_007481"
#> [95] "KBio3_002205"
#> [96] "KBio3_002825"
#> [97] "EX-A708"
#> [98] "cMAP_000024"
#> [99] "HMS1922H11"
#> [100] "HMS2051G16"
#> [101] "HMS2089H20"
#> [102] "HMS2093E04"
#> [103] "HMS2232G21"
#> [104] "HMS3371P11"
#> [105] "HMS3393G16"
#> [106] "HMS3651F16"
#> [107] "HMS3713B07"
#> [108] "HMS3750I17"
#> [109] "HMS3885E05"
#> [110] "Pharmakon1600-01504235"
#> [111] "BCP03619"
#> [112] "Tox21_111430"
#> [113] "CCG-40253"
#> [114] "NSC758705"
#> [115] "s3043"
#> [116] "STK635144"
#> [117] "AKOS000280931"
#> [118] "AB07701"
#> [119] "CS-0997"
#> [120] "DB00533"
#> [121] "NC00132"
#> [122] "SB19518"
#> [123] "NCGC00095118-02"
#> [124] "NCGC00095118-03"
#> [125] "NCGC00095118-04"
#> [126] "NCGC00095118-05"
#> [127] "NCGC00095118-08"
#> [128] "NCGC00095118-17"
#> [129] "NCGC00095118-18"
#> [130] "AC-28318"
#> [131] "BR164362"
#> [132] "HY-17372"
#> [133] "NCI60_041175"
#> [134] "SBI-0206774.P001"
#> [135] "CAS-162011-90-7"
#> [136] "NS00003940"
#> [137] "R0206"
#> [138] "SW219668-1"
#> [139] "C07590"
#> [140] "D00568"
#> [141] "AB00052090-06"
#> [142] "AB00052090-08"
#> [143] "AB00052090_09"
#> [144] "AB00052090_10"
#> [145] "EN300-7364304"
#> [146] "L000912"
#> [147] "Q411412"
#> [148] "Q-201676"
#> [149] "SR-01000762904-3"
#> [150] "SR-01000762904-5"
#> [151] "BRD-K21733600-001-02-6"
#> [152] "BRD-K21733600-001-06-7"
#> [153] "BRD-K21733600-001-14-1"
#> [154] "BRD-K21733600-001-15-8"
#> [155] "BRD-K21733600-001-19-0"
#> [156] "BRD-K21733600-001-23-2"
#> [157] "BRD-K21733600-001-24-0"
#> [158] "3-(4-methanesulfonyl-phenyl)-2-phenyl-2-buten-4-olide"
#> [159] "4-(4'-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone"
#> [160] "Z2037279770"
#> [161] "2(5H)-Furanone, 4-[4-(methyl-sulfonyl)phenyl]-3-phenyl-"
#> [162] "3-(Phenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone"
#> [163] "3-Phenyl-4-(4-(Methylsulfonyl)Phenyl)-2-(5H)-Furanone"
#> [164] "4-(4-METHANESULFONYL-PHENYL)-3-PHENYL-5H-FURAN-2-ONE"
#> [165] "4-(4-methylsulfonylphenyl)-3-phenyl-2,5-dihydro-2-furanone"5. Cross-References (XRefs): PUG REST provides access to various cross-references. For example, to retrieve MMDB identifiers for protein structures containing aspirin:
result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", operation = c("xrefs","MMDBID"), output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Compound
#> - Namespace: CID
#> - Operation: xrefs
#> - Identifier: 2244
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $InformationList
#> $InformationList$Information
#> $InformationList$Information[[1]]
#> $InformationList$Information[[1]]$CID
#> [1] 2244
#>
#> $InformationList$Information[[1]]$MMDBID
#> [1] 115960 173465 230639 27242 27954 54234 70578 75951Or to find all patent identifiers associated with a given SID:
result <- get_pug_rest(identifier = "137349406", namespace = "sid", domain = "substance", operation = c("xrefs","PatentID"), output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Substance
#> - Namespace: SID
#> - Operation: xrefs
#> - Identifier: 137349406
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 US20030181500A1
#> 2 US20050059720A1
#> 3 US20050124633A1
#> 4 US20050124634A1
#> 5 US20050159403A1
#> 6 US20060008862A1
#> 7 US20060135506A1
#> 8 US20070142442A1
#> 9 US20070179152A1
#> 10 US20070196421A1
#> 11 US20070197957A1
#> 12 US20070198063A1
#> 13 US20070208134A1
#> 14 US20070299043A1
#> 15 US20080125595A1
#> 16 US20090075960A1
#> 17 US20100144696A1
#> 18 US20100144697A1
#> 19 US20100267704A1
#> 20 US20110098273A1
#> 21 US20110177999A1
#> 22 US20110201811A1
#> 23 US7485653
#> 24 US7488721
#> 25 US7585978These examples illustrate the versatility of PUG REST in fetching specific data efficiently. It’s an ideal tool for users who need quick access to particular pieces of information from the vast PubChem database without the overhead of processing bulk data.
PubChem BioAssays are complex entities containing a wealth of data. PUG REST provides access to both complete assay records and specific components of BioAssay data, allowing users to efficiently retrieve the information they need.
1. Assay Description: To obtain the description section of a BioAssay, which includes authorship, general description, protocol, and data readout definitions, use a request like:
result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "description", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: description
#> - Identifier: 504526
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $PC_AssayContainer
#> $PC_AssayContainer[[1]]
#> $PC_AssayContainer[[1]]$assay
#> $PC_AssayContainer[[1]]$assay$descr
#> $PC_AssayContainer[[1]]$assay$descr$aid
#> id version
#> 504526 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$aid_source
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$name
#> [1] "Southern Research Specialized Biocontainment Screening Center"
#>
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$source_id
#> str
#> "RSV_DR6"
#>
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$date
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$date$std
#> year month day
#> 2012 3 18
#>
#>
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$name
#> [1] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#>
#> $PC_AssayContainer[[1]]$assay$descr$description
#> [1] "Southern Research's Specialized Biocontainment Screening Center (SRSBSC)"
#> [2] "Southern Research Institute (Birmingham, Alabama)"
#> [3] "NIH Molecular Libraries Probe Centers Network (MLPCN)"
#> [4] "Assay Provider: Dr. William Severson, Southern Research Institute "
#> [5] "Grant number: 1 R03 MH082403-01A1"
#> [6] ""
#> [7] "Assay Rationale and Summary: Currently, there are no commercially available vaccines to protect humans against Respiratory syncytial virus (RSV). RSV is associated with substantial morbidity and mortality and is the most common cause of bronchiolitis and pneumonia among infants and children under one year of age. Nevertheless, severe lower respiratory tract disease may occur at any age, especially among the elderly or among those with compromised cardiac, pulmonary, or immune systems. The existing therapies for the acute infection are ribavirin and the prophylactic humanized monoclonal antibody (Synagis from MedImmune) that is limited to use in high risk pediatric patients. The economic impact of RSV infections due to hospitalizations and indirect medical costs is greater than $ 650 million annually. The assay provider has developed and validated an HTS assay that measures cytopathic effect (CPE) induced in HEp-2 cells by RSV infection, using a luminescent-based detection system for signal endpoint. We anticipate that the proposed studies utilizing the Molecular Libraries Probes Production Network (MLPCN) HTS resources will generate multiple scaffolds targeting various junctures in the RSV viral lifecycle. These may be furthered developed into probes to construct novel single or combination therapeutics. "
#>
#> $PC_AssayContainer[[1]]$assay$descr$protocol
#> [1] "Cell Culture: HEp-2 cells (ATCC CCL-23, American Tissue Culture Type) were maintained as adherent cell lines in Optimem 1 with 2 mM L-glutamine and 10% fetal bovine serum (FBS) at 37oC in a humidified 5% CO2 atmosphere. Cells were passaged as needed and harvested from flasks using 0.05% trypsin-EDTA. "
#> [2] ""
#> [3] "Assay Media - Preparation of Complete DMEM/F12: 50 mL Pen/Strep/Glutamine (Gibco, Cat. No. 10378) was added to four liters of room temperature DMEM/F12 (Sigma, Cat. No. D6434) and the pH adjusted to 7.5 using 1N NaOH. The medium was sterile filtered through a 0.2 um filter and 10 mL of HI-FBS was added per 500 mL of media."
#> [4] ""
#> [5] "RSV culture: Human respiratory syncytial virus (HRSV) strain Long (ATCC VR-26) was used for screening. The RSV stock was prepared in HEp-2 cells using an initial stock obtained from ATCC. Briefly, HEp-2 cells were grown in two T-175 flasks to 50% confluence in Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12 (CDMEM/F12), pH 7.5 with 2.5 mM L-glutamine, 2% FBS and 125 U of penicillin, 125 ug of streptomycin per ml. 0.2 ml of RSV was added to 25 ml of CDMEM/F12. After three days incubation at 37 degrees C, 5% C02 and high humidity, the supernatant was harvested and the cell debris pelleted by centrifuging at 1,000 rpm for 5 minutes at 18 degrees C. Trehalose and FBS were added to a final concentration of 10% each and the supernatant was aliquoted (1 ml per tube) fast freeze using 100% Ethanol dry ice for five minutes and stored at -80 degrees C. These virus stocks were titrated in HEp-2 cells using an agarose overlay plaque method and the titer was 6.0E+07 pfu/ml. "
#> [6] ""
#> [7] "Dose Response Compound Preparation: For dose response screening, compounds or carrier control (DMSO) were diluted to 6x in Complete DMEM/F12. Test compounds were serially diluted 1:2 resulting in an 8 point dose response dilution series. (final plate well concentration ranging from 50 uM to 0.39 uM and a final DMSO concentration of 0.5%). Twenty ul of each dilution was dispensed to assay plates (3% DMSO) in triplicate."
#> [8] "Control Drug: The positive control drug for this assay, ribavirin [1] (No. 196066, MP Biomedicals, Solon, OH) was solubilized in DMSO. It was diluted and added to the assay plates as described for test compounds. Final concentration for ribavirin was 100uM. All wells contained 0.5% DMSO."
#> [9] ""
#> [10] "Preparation of HEp-2 cells: Cells were harvested and resuspended to 178,000 cells per ml in Complete DMEM/F12."
#> [11] ""
#> [12] "Assay Set up: Sixty ul of HEp-2 cells (10,595 cells/well) forty ul of media and 20 ul of 3% DMSO were plated in the cell control wells. Sixty ul of HEp-2 cells (10,595 cells/well), forty ul of a 1:500 dilution of virus (viral MOI = 0.45) and 20 ul of compound or ribavirin control drug were added to the virus control and compound wells. All cell plating was conducted using a Matrix WellMate and cells were maintained at room temperature with stirring during the plating process. The assay plates were incubated for six days at 37 degrees C, 5% CO2 and 90% relative humidity. "
#> [13] ""
#> [14] "Data Analysis: Eight control wells containing cells only and four wells containing cells and virus were included on each assay plate and used to calculate Z' value for each plate and to normalize the data on a per plate basis. Results are reported as percent (%) CPE inhibition and were calculated using the following formula: % CPE inhibition = 100*(Test Cmpd - Med Virus)/(Med Cells - Med Virus). Four ribavirin positive control wells were included on each plate for quality control purposes. To quantify the viral cytopathic effect, IC50s were calculated for each substance using the 4 parameter Levenburg-Marquardt algorithm with the minimum and maximum parameters locked at 0 and 100, respectively. "
#>
#> $PC_AssayContainer[[1]]$assay$descr$comment
#> [1] "Possible artifacts in this assay include, but are not limited to, compounds that interfere with the luciferase reaction, absorb luminescence, or precipitate."
#> [2] ""
#> [3] "Compounds that demonstrated at least 50% inhibition and were considered active. "
#> [4] ""
#> [5] "The following tiered system has been implemented at Southern Research Institute for use with the PubChem Score. Compounds in the primary screen are scored on a scale of 0-40 based on inhibitory activity where a score of 40 corresponds to 100% inhibition. In the initial confirmatory dose response screen, active compounds were scored on a scale of 41-80 based on the IC50 result while compounds that did not confirm as actives were given the score of 0. In assays using purified and synthesized compounds a scale of 81-100 based on the IC50 result is used to denote a high level of confidence in both the substance and the data. Compounds that did not confirm activity were given the score of 0."
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref
#> $PC_AssayContainer[[1]]$assay$descr$xref[[1]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[1]]$xref
#> aid
#> 2391
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[1]]$comment
#> [1] "Primary and confirmatory screen."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[2]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[2]]$xref
#> aid
#> 2410
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[2]]$comment
#> [1] "Cytotoxicity of primary screen hits."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[3]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[3]]$xref
#> aid
#> 449732
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[3]]$comment
#> [1] "TCID50 on selected compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[4]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[4]]$xref
#> aid
#> 488972
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[4]]$comment
#> [1] "Confirmatory screen (2) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[5]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[5]]$xref
#> aid
#> 488976
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[5]]$comment
#> [1] "Cytotoxicity screen (2) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[6]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[6]]$xref
#> aid
#> 2440
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[6]]$comment
#> [1] "Summary AID."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[7]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[7]]$xref
#> aid
#> 492966
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[7]]$comment
#> [1] "Confirmatory screen (3) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[8]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[8]]$xref
#> aid
#> 492968
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[8]]$comment
#> [1] "Cytotoxicity screen (3) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[9]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[9]]$xref
#> aid
#> 493016
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[9]]$comment
#> [1] "Confirmatory screen (4) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[10]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[10]]$xref
#> aid
#> 493015
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[10]]$comment
#> [1] "Cytotoxicity screen (4) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[11]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[11]]$xref
#> aid
#> 493088
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[11]]$comment
#> [1] "Confirmatory screen (5) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[12]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[12]]$xref
#> aid
#> 493090
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[12]]$comment
#> [1] "Cytotoxicity screen (5) on purified and synthesized compounds."
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$xref[[13]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[13]]$xref
#> taxonomy
#> 12814
#>
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$tid
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$name
#> [1] "IC50 Modifier"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$type
#> [1] 4
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$unit
#> [1] 254
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$tid
#> [1] 2
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$name
#> [1] "IC50"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$unit
#> [1] 5
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$ac
#> [1] TRUE
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$tid
#> [1] 3
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$name
#> [1] "% CPE Inhibition @ 50 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$description
#> [1] "Inhibition of cytopathic effect of virus at 50 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$tc
#> concentration unit dr_id
#> 50 5 1
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$tid
#> [1] 4
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$name
#> [1] "% CPE Inhibition @ 25 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$description
#> [1] "Inhibition of cytopathic effect of virus at 25 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$tc
#> concentration unit dr_id
#> 25 5 1
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$tid
#> [1] 5
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$name
#> [1] "% CPE Inhibition @ 12.5 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$description
#> [1] "Inhibition of cytopathic effect of virus at 12.50 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$tc
#> concentration unit dr_id
#> 12.5 5.0 1.0
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$tid
#> [1] 6
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$name
#> [1] "% CPE Inhibition @ 6.25 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$description
#> [1] "Inhibition of cytopathic effect of virus at 6.25 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$tc
#> concentration unit dr_id
#> 6.25 5.00 1.00
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$tid
#> [1] 7
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$name
#> [1] "% CPE Inhibition @ 3.125 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$description
#> [1] "Inhibition of cytopathic effect of virus at 3.125 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$tc
#> concentration unit dr_id
#> 3.125 5.000 1.000
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$tid
#> [1] 8
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$name
#> [1] "% CPE Inhibition @ 1.563 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$description
#> [1] "Inhibition of cytopathic effect of virus at 1.563 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$tc
#> concentration unit dr_id
#> 1.563 5.000 1.000
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$tid
#> [1] 9
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$name
#> [1] "% CPE Inhibition @ 0.781 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.781 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$tc
#> concentration unit dr_id
#> 0.781 5.000 1.000
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$tid
#> [1] 10
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$name
#> [1] "% CPE Inhibition @ 0.391 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.391 uM"
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$type
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$unit
#> [1] 15
#>
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$tc
#> concentration unit dr_id
#> 0.391 5.000 1.000
#>
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$revision
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$activity_outcome_method
#> [1] 2
#>
#> $PC_AssayContainer[[1]]$assay$descr$dr
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$id
#> [1] 1
#>
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$descr
#> [1] "CR Plot Labels 1"
#>
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$dn
#> [1] "Concentration"
#>
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$rn
#> [1] "Response"
#>
#>
#>
#> $PC_AssayContainer[[1]]$assay$descr$grant_number
#> [1] "1R03 MH084847-01"
#>
#> $PC_AssayContainer[[1]]$assay$descr$project_category
#> [1] 2For a simplified summary format that includes target information, active and inactive SID and CID counts:
result <- get_pug_rest(identifier = "1000", namespace = "aid", domain = "assay", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: summary
#> - Identifier: 1000
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $AssaySummaries
#> $AssaySummaries$AssaySummary
#> $AssaySummaries$AssaySummary[[1]]
#> $AssaySummaries$AssaySummary[[1]]$AID
#> [1] 1000
#>
#> $AssaySummaries$AssaySummary[[1]]$SourceName
#> [1] "SRMLSC"
#>
#> $AssaySummaries$AssaySummary[[1]]$SourceID
#> [1] "SPE-MK-Sec"
#>
#> $AssaySummaries$AssaySummary[[1]]$Name
#> [1] "Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Secondary Assay"
#>
#> $AssaySummaries$AssaySummary[[1]]$Description
#> [1] "Southern Research Molecular Libraries Screening Center (SRMLSC) "
#> [2] "Southern Research Institute (Birmingham, Alabama) "
#> [3] "NIH Molecular Libraries Screening Centers Network (MLSCN) "
#> [4] "Assay Provider: Dr. Thomas S. Leyh, Albert Einstein College of medicine of Yeshiva University "
#> [5] "Award: R03 MH078936-01"
#> [6] ""
#> [7] "Streptococcus pneumonia (SP) takes the lives of nearly 4,000 people daily and antibiotic resistant strains are becoming an increasing problem. Because of this, the discovery of drugs targeting novel pathways such as the mevalonate pathway has become increasingly important. The pathway produces isopentyl diphosphate (the molecular building block of isoprenoids) and is essential for the survival of the pathogen in mouse lung and serum. The mevalonate pathway is comprised of three consecutive reactions that are catalyzed by the enzymes mevalonate kinase (MK; E.C. 2.7.1.36), phosphomevalonate kinase (PMK; E.C. 2.7.4.2), and diphosphomevalonate decarboxylase (PDM-DC; E.C. 4.1.1.33). MK catalyzes the ATP dependent conversion of (R)-mevalonate to ADP plus (R)-5-phosphomevalonate. "
#> [8] ""
#> [9] "The activity of MK was measured spectrophotometrically by coupling the formation of ADP to the reactions of pyruvate kinase and lactate dehydrogenase. The rate of ADP formation was quantitated by the reduction of absorbance (OD340) due to the oxidation of NADH to NAD by lactate dehydrogenase. A kinetic assay was chosen to minimize interference by compounds that absorbed at 340 nm."
#> [10] ""
#> [11] "A total of 57 compounds were initially screened at a final concentration of 100 uM. Compounds with more than 20% inhibition at 100 uM were then tested in dose response assays at seven concentrations, ranging from 100 uM to 0.0156 uM depending on the % inhibition for each compound in the initial 100 uM screen. To confirm that the compounds were specifically inhibiting MK and not one of the other enzymes in the assay, the compounds were tested in parallel in an assay that contained hexokinase as the enzyme instead of MK and glucose as the substrate instead of mevalonate. None of the compounds tested inhibited in this 'coupling enzymes' assay."
#>
#> $AssaySummaries$AssaySummary[[1]]$Protocol
#> [1] "Mevalonate Kinase Protocol for 1 mL cuvet assay"
#> [2] ""
#> [3] "Purified recombinant MK enzyme was provided by Dr. Thomas Leyh, Albert Einstein College of Medicine of Yeshiva University. "
#> [4] ""
#> [5] "590 uL of MK reagent mix which included NADH, mevalonate, ATP, phosphoenolpyruvate, MgCl2, KCl, pyruvate kinase, and lactate dehydrogenase in buffer was added to each UV-VIS semimicro cuvet. Compounds were then added to the cuvets in 10 uL volumes in DMSO. The reaction was initiated with the addition of 400 uL of MK, diluted in assay buffer. The final concentrations in the reaction were 0.4 mM NADH, 0.2 mM melalonate, 6 mM MgCl2, 50 mM KCl, 5 mM ATP, 2 mM potassium phosphoenolpyruvate, 3 units/mL each of rabbit muscle pyruvate kinase and rabbit muscle lactate dehydrogenase, 1% DMSO, and 60 nM Mevalonate Kinase (MK) diluted in 50 mM HEPES buffer (pH 7.8) in a final volume of 1000 uL. The cuvets were immediately transferred to a CARY 3E UV-Visible Spectrophotometer and absorbance was measured at 340 nm for 3 minutes. Each compound was tested in triplicate for the initial 100 uM screen and for the dose response assays each concentration was in triplicate. Full reaction controls were assays with 10 uL of DMSO added instead of compound. Background controls were assays in which 400 uL of assay buffer was added instead of MK. "
#> [6] ""
#> [7] "The 'coupling enzyme' assays were performed as above by replacing MK with hexokinase and mevalonate with glucose."
#>
#> $AssaySummaries$AssaySummary[[1]]$Comment
#> [1] "Percent inhibition in the single dose assay was determined by comparing the reaction rates of the compounds to that of the rate for the full reaction after subtracting the background rate using the following equation: "
#> [2] ""
#> [3] "% Inhib = 100*(1-((cmpd rate-bkgrd rate)/ (full rx rate-bkgrd rate))) "
#> [4] ""
#> [5] "Dose response curves were analyzed using the four parameter logistic formula in SigmaPlot Enzyme Kinetics software."
#> [6] " "
#> [7] "In this confirmatory dose response screen active compounds were scored on a scale of 41-80 using an inverted linear correlation to EC50s between 0 and 40 uM. Compounds that did not confirm as actives in the dose response screen were given the score 0. "
#>
#> $AssaySummaries$AssaySummary[[1]]$NumberOfTIDs
#> [1] 27
#>
#> $AssaySummaries$AssaySummary[[1]]$HasScore
#> [1] TRUE
#>
#> $AssaySummaries$AssaySummary[[1]]$Method
#> [1] "confirmatory"
#>
#> $AssaySummaries$AssaySummary[[1]]$Target
#> $AssaySummaries$AssaySummary[[1]]$Target[[1]]
#> Accession Name
#> "YP_815859" "mevalonate kinase"
#>
#>
#> $AssaySummaries$AssaySummary[[1]]$Version
#> [1] 1
#>
#> $AssaySummaries$AssaySummary[[1]]$Revision
#> [1] 2
#>
#> $AssaySummaries$AssaySummary[[1]]$LastDataChange
#> Year Month Day
#> 2008 3 5
#>
#> $AssaySummaries$AssaySummary[[1]]$SIDCountAll
#> [1] 57
#>
#> $AssaySummaries$AssaySummary[[1]]$SIDCountActive
#> [1] 36
#>
#> $AssaySummaries$AssaySummary[[1]]$SIDCountInactive
#> [1] 21
#>
#> $AssaySummaries$AssaySummary[[1]]$SIDCountInconclusive
#> [1] 0
#>
#> $AssaySummaries$AssaySummary[[1]]$SIDCountUnspecified
#> [1] 0
#>
#> $AssaySummaries$AssaySummary[[1]]$SIDCountProbe
#> [1] 0
#>
#> $AssaySummaries$AssaySummary[[1]]$CIDCountAll
#> [1] 57
#>
#> $AssaySummaries$AssaySummary[[1]]$CIDCountActive
#> [1] 36
#>
#> $AssaySummaries$AssaySummary[[1]]$CIDCountInactive
#> [1] 21
#>
#> $AssaySummaries$AssaySummary[[1]]$CIDCountInconclusive
#> [1] 0
#>
#> $AssaySummaries$AssaySummary[[1]]$CIDCountUnspecified
#> [1] 0
#>
#> $AssaySummaries$AssaySummary[[1]]$CIDCountProbe
#> [1] 02. Assay Data: To retrieve the entire data set of an assay in CSV format:
result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", output = "CSV")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: <NULL>
#> - Identifier: 504526
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> PUBCHEM_RESULT_TAG PUBCHEM_SID PUBCHEM_CID
#> 1 RESULT_TYPE NA NA
#> 2 RESULT_DESCR NA NA
#> 3 RESULT_UNIT NA NA
#> 4 RESULT_IS_ACTIVE_CONCENTRATION NA NA
#> 5 RESULT_ATTR_CONC_MICROMOL NA NA
#> 6 1 103061373 6619281
#> 7 2 103904139 2971528
#> 8 3 109967230 50897767
#> 9 4 109967232 50897761
#> 10 5 109967235 50897759
#> 11 6 104222572 22429344
#> 12 7 104169543 49842897
#> 13 8 104169547 6619281
#> 14 9 104169544 49842896
#> 15 10 104169548 49842898
#> 16 11 103904144 4969604
#> 17 12 109967231 50897764
#> 18 13 109967233 50897765
#> 19 14 109967234 50897766
#> 20 15 109967236 50897760
#> 21 16 109967237 50897763
#> 22 17 109967238 50897762
#> 23 18 109967239 50897768
#> 24 19 104222567 49852456
#> 25 20 104222568 49852454
#> 26 21 104222569 22429370
#> 27 22 104222570 15996204
#> 28 23 104222571 49852455
#> 29 24 104169545 1077725
#> 30 25 104169546 5308867
#> PUBCHEM_EXT_DATASOURCE_SMILES
#> 1
#> 2
#> 3
#> 4
#> 5
#> 6 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 7 C1CC2=CC=CC=C2N(C1)S(=O)(=O)C3=CC=C(C=C3)NC(=O)C4CC=CCC4C(=O)O
#> 8 CC1=CC=C(C=C1)CN2C3=CC=CC=C3C(=O)N(C2=O)CC4=CC=C(C=C4)C(=O)NCCOC
#> 9 CC1=C(C=C(C=C1)Cl)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 10 CC1=C(C=C(C=C1)OC)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 11 C1CN(CCC1C(=O)NCC2=CC=CC=C2Cl)S(=O)(=O)C3=CC=CC4=NON=C43
#> 12 CC1=CC(=C(C=C1)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 13 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 14 CC1=C(C(=CC=C1)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 15 COC1=CC=CC=C1CNC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 16 COC1=CC=CC=C1NCC(=O)NC2=C(C=CC(=C2)S(=O)(=O)N3CCOCC3)N4CCOCC4
#> 17 CC1=CC=C(C=C1)CN2C3=C(C=CC(=C3)Cl)C(=O)N(C2=O)CC4=CC=C(C=C4)C(=O)NCCCOC
#> 18 CC1=C(C=C(C=C1)C(C)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 19 CC1=CC(=C(C=C1)OC)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 20 CC1=CC(=C(C=C1)Cl)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 21 CC1=C(C=C(C=C1)C(F)(F)F)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 22 CC1=C(C=C(C=C1)C(C)(C)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 23 COCCCNC(=O)C1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3N(C2=O)CC4=CC=CC=C4
#> 24 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=C3N=CS4
#> 25 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)CC3=CC=CC4=NON=C43
#> 26 COC1=CC=CC(=C1)CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 27 COC1=CC=C(C=C1)CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 28 CC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 29 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3
#> 30 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> PUBCHEM_ACTIVITY_OUTCOME PUBCHEM_ACTIVITY_SCORE PUBCHEM_ACTIVITY_URL
#> 1 NA NA
#> 2 NA NA
#> 3 NA NA
#> 4 NA NA
#> 5 NA NA
#> 6 Active 99 NA
#> 7 Active 88 NA
#> 8 Active 99 NA
#> 9 Active 100 NA
#> 10 Active 99 NA
#> 11 Active 98 NA
#> 12 Active 98 NA
#> 13 Active 99 NA
#> 14 Active 87 NA
#> 15 Active 93 NA
#> 16 Inactive 81 NA
#> 17 Inactive 81 NA
#> 18 Inactive 81 NA
#> 19 Inactive 81 NA
#> 20 Inactive 81 NA
#> 21 Inactive 81 NA
#> 22 Inactive 81 NA
#> 23 Inactive 81 NA
#> 24 Inactive 81 NA
#> 25 Inactive 81 NA
#> 26 Inactive 81 NA
#> 27 Inactive 81 NA
#> 28 Inactive 81 NA
#> 29 Inactive 81 NA
#> 30 Inactive 81 NA
#> PUBCHEM_ASSAYDATA_COMMENT IC50.Modifier IC50
#> 1 NA STRING FLOAT
#> 2 NA
#> 3 NA NONE MICROMOLAR
#> 4 NA TRUE
#> 5 NA
#> 6 NA 3.6
#> 7 NA 31.4
#> 8 NA 2.32
#> 9 NA 0.22
#> 10 NA 3.51
#> 11 NA 6.9
#> 12 NA 5.1
#> 13 NA 4.7
#> 14 NA 34.6
#> 15 NA 18.8
#> 16 NA > 50
#> 17 NA > 50
#> 18 NA > 50
#> 19 NA > 50
#> 20 NA > 50
#> 21 NA > 50
#> 22 NA > 50
#> 23 NA > 50
#> 24 NA > 50
#> 25 NA > 50
#> 26 NA > 50
#> 27 NA > 50
#> 28 NA > 50
#> 29 NA > 50
#> 30 NA > 50
#> X..CPE.Inhibition...50.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 50 uM
#> 3 PERCENT
#> 4
#> 5 50
#> 6 78.38
#> 7 47.67
#> 8 107.05
#> 9 7.51
#> 10 88.79
#> 11 78.03
#> 12 43.94
#> 13 85.88
#> 14 59.74
#> 15 72.51
#> 16 0.42
#> 17 2.59
#> 18 30.79
#> 19 9.1
#> 20 3.2
#> 21 12.15
#> 22 2.49
#> 23 2.1
#> 24 0.59
#> 25 0.58
#> 26 0.96
#> 27 1.83
#> 28 2
#> 29 0.55
#> 30 0.51
#> X..CPE.Inhibition...25.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 25 uM
#> 3 PERCENT
#> 4
#> 5 25
#> 6 97.5
#> 7 68.41
#> 8 90.78
#> 9 9.47
#> 10 90.14
#> 11 86.65
#> 12 91.27
#> 13 92.21
#> 14 42.48
#> 15 61.24
#> 16 0.56
#> 17 2.63
#> 18 21.08
#> 19 11.2
#> 20 6.08
#> 21 3.83
#> 22 4.66
#> 23 2.52
#> 24 0.77
#> 25 0.54
#> 26 0.98
#> 27 1.5
#> 28 2.18
#> 29 0.69
#> 30 0.51
#> X..CPE.Inhibition...12.5.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 12.50 uM
#> 3 PERCENT
#> 4
#> 5 12.5
#> 6 94.84
#> 7 16.83
#> 8 87.53
#> 9 60.4
#> 10 77.74
#> 11 83.45
#> 12 82.68
#> 13 91.99
#> 14 21.56
#> 15 40.57
#> 16 0.62
#> 17 2.32
#> 18 27.55
#> 19 10.88
#> 20 34.16
#> 21 8.53
#> 22 4.19
#> 23 1.87
#> 24 0.76
#> 25 0.53
#> 26 0.94
#> 27 1.11
#> 28 1.73
#> 29 0.74
#> 30 0.52
#> X..CPE.Inhibition...6.25.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 6.25 uM
#> 3 PERCENT
#> 4
#> 5 6.25
#> 6 95.43
#> 7 2.14
#> 8 101.19
#> 9 79.75
#> 10 66.47
#> 11 47.02
#> 12 66.81
#> 13 78.58
#> 14 8.54
#> 15 19
#> 16 0.43
#> 17 2.49
#> 18 17.89
#> 19 7.76
#> 20 17.15
#> 21 39.9
#> 22 3.38
#> 23 1.93
#> 24 0.94
#> 25 0.49
#> 26 0.89
#> 27 0.77
#> 28 1.56
#> 29 0.88
#> 30 0.43
#> X..CPE.Inhibition...3.125.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 3.125 uM
#> 3 PERCENT
#> 4
#> 5 3.125
#> 6 35.06
#> 7 1.07
#> 8 80.54
#> 9 72.51
#> 10 48.34
#> 11 12.2
#> 12 39.43
#> 13 14.87
#> 14 4.49
#> 15 8.08
#> 16 0.51
#> 17 1.96
#> 18 6.44
#> 19 4.61
#> 20 8.56
#> 21 30.03
#> 22 2.38
#> 23 1.62
#> 24 0.79
#> 25 0.5
#> 26 1.09
#> 27 0.64
#> 28 1.19
#> 29 0.95
#> 30 0.58
#> X..CPE.Inhibition...1.563.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 1.563 uM
#> 3 PERCENT
#> 4
#> 5 1.563
#> 6 3.21
#> 7 0.93
#> 8 15.81
#> 9 59.35
#> 10 32.2
#> 11 2.23
#> 12 18.27
#> 13 2.15
#> 14 2.69
#> 15 3.66
#> 16 0.38
#> 17 1.8
#> 18 3.41
#> 19 3.29
#> 20 4.66
#> 21 14.27
#> 22 1.7
#> 23 1.42
#> 24 0.8
#> 25 0.39
#> 26 0.98
#> 27 0.51
#> 28 0.93
#> 29 0.78
#> 30 0.46
#> X..CPE.Inhibition...0.781.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 0.781 uM
#> 3 PERCENT
#> 4
#> 5 0.781
#> 6 1.08
#> 7 0.84
#> 8 4.66
#> 9 35.87
#> 10 15.81
#> 11 0.77
#> 12 6.99
#> 13 0.79
#> 14 1.51
#> 15 1.59
#> 16 0.44
#> 17 1.19
#> 18 2.54
#> 19 2.06
#> 20 3.13
#> 21 5.48
#> 22 1.37
#> 23 1.31
#> 24 0.77
#> 25 0.36
#> 26 0.89
#> 27 0.48
#> 28 0.8
#> 29 0.75
#> 30 0.62
#> X..CPE.Inhibition...0.391.uM
#> 1 FLOAT
#> 2 Inhibition of cytopathic effect of virus at 0.391 uM
#> 3 PERCENT
#> 4
#> 5 0.391
#> 6 0.7
#> 7 0.74
#> 8 2.32
#> 9 13.62
#> 10 5.72
#> 11 0.65
#> 12 4.01
#> 13 0.54
#> 14 0.94
#> 15 1.04
#> 16 0.45
#> 17 1.06
#> 18 1.48
#> 19 1.52
#> 20 1.93
#> 21 3.58
#> 22 1.06
#> 23 1.27
#> 24 0.73
#> 25 0.53
#> 26 0.71
#> 27 0.57
#> 28 0.74
#> 29 0.7
#> 30 0.51For a subset of data rows, specify the SIDs:
result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "JSON?sid=104169547,109967232", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: JSON?sid=104169547,109967232
#> - Identifier: 504526
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.result <- pubChemData(result)
result$PC_AssaySubmit$assay
#> $descr
#> $descr$aid
#> id version
#> 504526 1
#>
#> $descr$aid_source
#> $descr$aid_source$db
#> $descr$aid_source$db$name
#> [1] "Southern Research Specialized Biocontainment Screening Center"
#>
#> $descr$aid_source$db$source_id
#> str
#> "RSV_DR6"
#>
#> $descr$aid_source$db$date
#> $descr$aid_source$db$date$std
#> year month day
#> 2012 3 18
#>
#>
#>
#>
#> $descr$name
#> [1] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#>
#> $descr$description
#> [1] "Southern Research's Specialized Biocontainment Screening Center (SRSBSC)"
#> [2] "Southern Research Institute (Birmingham, Alabama)"
#> [3] "NIH Molecular Libraries Probe Centers Network (MLPCN)"
#> [4] "Assay Provider: Dr. William Severson, Southern Research Institute "
#> [5] "Grant number: 1 R03 MH082403-01A1"
#> [6] ""
#> [7] "Assay Rationale and Summary: Currently, there are no commercially available vaccines to protect humans against Respiratory syncytial virus (RSV). RSV is associated with substantial morbidity and mortality and is the most common cause of bronchiolitis and pneumonia among infants and children under one year of age. Nevertheless, severe lower respiratory tract disease may occur at any age, especially among the elderly or among those with compromised cardiac, pulmonary, or immune systems. The existing therapies for the acute infection are ribavirin and the prophylactic humanized monoclonal antibody (Synagis from MedImmune) that is limited to use in high risk pediatric patients. The economic impact of RSV infections due to hospitalizations and indirect medical costs is greater than $ 650 million annually. The assay provider has developed and validated an HTS assay that measures cytopathic effect (CPE) induced in HEp-2 cells by RSV infection, using a luminescent-based detection system for signal endpoint. We anticipate that the proposed studies utilizing the Molecular Libraries Probes Production Network (MLPCN) HTS resources will generate multiple scaffolds targeting various junctures in the RSV viral lifecycle. These may be furthered developed into probes to construct novel single or combination therapeutics. "
#>
#> $descr$protocol
#> [1] "Cell Culture: HEp-2 cells (ATCC CCL-23, American Tissue Culture Type) were maintained as adherent cell lines in Optimem 1 with 2 mM L-glutamine and 10% fetal bovine serum (FBS) at 37oC in a humidified 5% CO2 atmosphere. Cells were passaged as needed and harvested from flasks using 0.05% trypsin-EDTA. "
#> [2] ""
#> [3] "Assay Media - Preparation of Complete DMEM/F12: 50 mL Pen/Strep/Glutamine (Gibco, Cat. No. 10378) was added to four liters of room temperature DMEM/F12 (Sigma, Cat. No. D6434) and the pH adjusted to 7.5 using 1N NaOH. The medium was sterile filtered through a 0.2 um filter and 10 mL of HI-FBS was added per 500 mL of media."
#> [4] ""
#> [5] "RSV culture: Human respiratory syncytial virus (HRSV) strain Long (ATCC VR-26) was used for screening. The RSV stock was prepared in HEp-2 cells using an initial stock obtained from ATCC. Briefly, HEp-2 cells were grown in two T-175 flasks to 50% confluence in Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12 (CDMEM/F12), pH 7.5 with 2.5 mM L-glutamine, 2% FBS and 125 U of penicillin, 125 ug of streptomycin per ml. 0.2 ml of RSV was added to 25 ml of CDMEM/F12. After three days incubation at 37 degrees C, 5% C02 and high humidity, the supernatant was harvested and the cell debris pelleted by centrifuging at 1,000 rpm for 5 minutes at 18 degrees C. Trehalose and FBS were added to a final concentration of 10% each and the supernatant was aliquoted (1 ml per tube) fast freeze using 100% Ethanol dry ice for five minutes and stored at -80 degrees C. These virus stocks were titrated in HEp-2 cells using an agarose overlay plaque method and the titer was 6.0E+07 pfu/ml. "
#> [6] ""
#> [7] "Dose Response Compound Preparation: For dose response screening, compounds or carrier control (DMSO) were diluted to 6x in Complete DMEM/F12. Test compounds were serially diluted 1:2 resulting in an 8 point dose response dilution series. (final plate well concentration ranging from 50 uM to 0.39 uM and a final DMSO concentration of 0.5%). Twenty ul of each dilution was dispensed to assay plates (3% DMSO) in triplicate."
#> [8] "Control Drug: The positive control drug for this assay, ribavirin [1] (No. 196066, MP Biomedicals, Solon, OH) was solubilized in DMSO. It was diluted and added to the assay plates as described for test compounds. Final concentration for ribavirin was 100uM. All wells contained 0.5% DMSO."
#> [9] ""
#> [10] "Preparation of HEp-2 cells: Cells were harvested and resuspended to 178,000 cells per ml in Complete DMEM/F12."
#> [11] ""
#> [12] "Assay Set up: Sixty ul of HEp-2 cells (10,595 cells/well) forty ul of media and 20 ul of 3% DMSO were plated in the cell control wells. Sixty ul of HEp-2 cells (10,595 cells/well), forty ul of a 1:500 dilution of virus (viral MOI = 0.45) and 20 ul of compound or ribavirin control drug were added to the virus control and compound wells. All cell plating was conducted using a Matrix WellMate and cells were maintained at room temperature with stirring during the plating process. The assay plates were incubated for six days at 37 degrees C, 5% CO2 and 90% relative humidity. "
#> [13] ""
#> [14] "Data Analysis: Eight control wells containing cells only and four wells containing cells and virus were included on each assay plate and used to calculate Z' value for each plate and to normalize the data on a per plate basis. Results are reported as percent (%) CPE inhibition and were calculated using the following formula: % CPE inhibition = 100*(Test Cmpd - Med Virus)/(Med Cells - Med Virus). Four ribavirin positive control wells were included on each plate for quality control purposes. To quantify the viral cytopathic effect, IC50s were calculated for each substance using the 4 parameter Levenburg-Marquardt algorithm with the minimum and maximum parameters locked at 0 and 100, respectively. "
#>
#> $descr$comment
#> [1] "Possible artifacts in this assay include, but are not limited to, compounds that interfere with the luciferase reaction, absorb luminescence, or precipitate."
#> [2] ""
#> [3] "Compounds that demonstrated at least 50% inhibition and were considered active. "
#> [4] ""
#> [5] "The following tiered system has been implemented at Southern Research Institute for use with the PubChem Score. Compounds in the primary screen are scored on a scale of 0-40 based on inhibitory activity where a score of 40 corresponds to 100% inhibition. In the initial confirmatory dose response screen, active compounds were scored on a scale of 41-80 based on the IC50 result while compounds that did not confirm as actives were given the score of 0. In assays using purified and synthesized compounds a scale of 81-100 based on the IC50 result is used to denote a high level of confidence in both the substance and the data. Compounds that did not confirm activity were given the score of 0."
#>
#> $descr$xref
#> $descr$xref[[1]]
#> $descr$xref[[1]]$xref
#> aid
#> 2391
#>
#> $descr$xref[[1]]$comment
#> [1] "Primary and confirmatory screen."
#>
#>
#> $descr$xref[[2]]
#> $descr$xref[[2]]$xref
#> aid
#> 2410
#>
#> $descr$xref[[2]]$comment
#> [1] "Cytotoxicity of primary screen hits."
#>
#>
#> $descr$xref[[3]]
#> $descr$xref[[3]]$xref
#> aid
#> 449732
#>
#> $descr$xref[[3]]$comment
#> [1] "TCID50 on selected compounds."
#>
#>
#> $descr$xref[[4]]
#> $descr$xref[[4]]$xref
#> aid
#> 488972
#>
#> $descr$xref[[4]]$comment
#> [1] "Confirmatory screen (2) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[5]]
#> $descr$xref[[5]]$xref
#> aid
#> 488976
#>
#> $descr$xref[[5]]$comment
#> [1] "Cytotoxicity screen (2) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[6]]
#> $descr$xref[[6]]$xref
#> aid
#> 2440
#>
#> $descr$xref[[6]]$comment
#> [1] "Summary AID."
#>
#>
#> $descr$xref[[7]]
#> $descr$xref[[7]]$xref
#> aid
#> 492966
#>
#> $descr$xref[[7]]$comment
#> [1] "Confirmatory screen (3) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[8]]
#> $descr$xref[[8]]$xref
#> aid
#> 492968
#>
#> $descr$xref[[8]]$comment
#> [1] "Cytotoxicity screen (3) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[9]]
#> $descr$xref[[9]]$xref
#> aid
#> 493016
#>
#> $descr$xref[[9]]$comment
#> [1] "Confirmatory screen (4) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[10]]
#> $descr$xref[[10]]$xref
#> aid
#> 493015
#>
#> $descr$xref[[10]]$comment
#> [1] "Cytotoxicity screen (4) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[11]]
#> $descr$xref[[11]]$xref
#> aid
#> 493088
#>
#> $descr$xref[[11]]$comment
#> [1] "Confirmatory screen (5) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[12]]
#> $descr$xref[[12]]$xref
#> aid
#> 493090
#>
#> $descr$xref[[12]]$comment
#> [1] "Cytotoxicity screen (5) on purified and synthesized compounds."
#>
#>
#> $descr$xref[[13]]
#> $descr$xref[[13]]$xref
#> taxonomy
#> 12814
#>
#>
#>
#> $descr$results
#> $descr$results[[1]]
#> $descr$results[[1]]$tid
#> [1] 1
#>
#> $descr$results[[1]]$name
#> [1] "IC50 Modifier"
#>
#> $descr$results[[1]]$type
#> [1] 4
#>
#> $descr$results[[1]]$unit
#> [1] 254
#>
#>
#> $descr$results[[2]]
#> $descr$results[[2]]$tid
#> [1] 2
#>
#> $descr$results[[2]]$name
#> [1] "IC50"
#>
#> $descr$results[[2]]$type
#> [1] 1
#>
#> $descr$results[[2]]$unit
#> [1] 5
#>
#> $descr$results[[2]]$ac
#> [1] TRUE
#>
#>
#> $descr$results[[3]]
#> $descr$results[[3]]$tid
#> [1] 3
#>
#> $descr$results[[3]]$name
#> [1] "% CPE Inhibition @ 50 uM"
#>
#> $descr$results[[3]]$description
#> [1] "Inhibition of cytopathic effect of virus at 50 uM"
#>
#> $descr$results[[3]]$type
#> [1] 1
#>
#> $descr$results[[3]]$unit
#> [1] 15
#>
#> $descr$results[[3]]$tc
#> concentration unit dr_id
#> 50 5 1
#>
#>
#> $descr$results[[4]]
#> $descr$results[[4]]$tid
#> [1] 4
#>
#> $descr$results[[4]]$name
#> [1] "% CPE Inhibition @ 25 uM"
#>
#> $descr$results[[4]]$description
#> [1] "Inhibition of cytopathic effect of virus at 25 uM"
#>
#> $descr$results[[4]]$type
#> [1] 1
#>
#> $descr$results[[4]]$unit
#> [1] 15
#>
#> $descr$results[[4]]$tc
#> concentration unit dr_id
#> 25 5 1
#>
#>
#> $descr$results[[5]]
#> $descr$results[[5]]$tid
#> [1] 5
#>
#> $descr$results[[5]]$name
#> [1] "% CPE Inhibition @ 12.5 uM"
#>
#> $descr$results[[5]]$description
#> [1] "Inhibition of cytopathic effect of virus at 12.50 uM"
#>
#> $descr$results[[5]]$type
#> [1] 1
#>
#> $descr$results[[5]]$unit
#> [1] 15
#>
#> $descr$results[[5]]$tc
#> concentration unit dr_id
#> 12.5 5.0 1.0
#>
#>
#> $descr$results[[6]]
#> $descr$results[[6]]$tid
#> [1] 6
#>
#> $descr$results[[6]]$name
#> [1] "% CPE Inhibition @ 6.25 uM"
#>
#> $descr$results[[6]]$description
#> [1] "Inhibition of cytopathic effect of virus at 6.25 uM"
#>
#> $descr$results[[6]]$type
#> [1] 1
#>
#> $descr$results[[6]]$unit
#> [1] 15
#>
#> $descr$results[[6]]$tc
#> concentration unit dr_id
#> 6.25 5.00 1.00
#>
#>
#> $descr$results[[7]]
#> $descr$results[[7]]$tid
#> [1] 7
#>
#> $descr$results[[7]]$name
#> [1] "% CPE Inhibition @ 3.125 uM"
#>
#> $descr$results[[7]]$description
#> [1] "Inhibition of cytopathic effect of virus at 3.125 uM"
#>
#> $descr$results[[7]]$type
#> [1] 1
#>
#> $descr$results[[7]]$unit
#> [1] 15
#>
#> $descr$results[[7]]$tc
#> concentration unit dr_id
#> 3.125 5.000 1.000
#>
#>
#> $descr$results[[8]]
#> $descr$results[[8]]$tid
#> [1] 8
#>
#> $descr$results[[8]]$name
#> [1] "% CPE Inhibition @ 1.563 uM"
#>
#> $descr$results[[8]]$description
#> [1] "Inhibition of cytopathic effect of virus at 1.563 uM"
#>
#> $descr$results[[8]]$type
#> [1] 1
#>
#> $descr$results[[8]]$unit
#> [1] 15
#>
#> $descr$results[[8]]$tc
#> concentration unit dr_id
#> 1.563 5.000 1.000
#>
#>
#> $descr$results[[9]]
#> $descr$results[[9]]$tid
#> [1] 9
#>
#> $descr$results[[9]]$name
#> [1] "% CPE Inhibition @ 0.781 uM"
#>
#> $descr$results[[9]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.781 uM"
#>
#> $descr$results[[9]]$type
#> [1] 1
#>
#> $descr$results[[9]]$unit
#> [1] 15
#>
#> $descr$results[[9]]$tc
#> concentration unit dr_id
#> 0.781 5.000 1.000
#>
#>
#> $descr$results[[10]]
#> $descr$results[[10]]$tid
#> [1] 10
#>
#> $descr$results[[10]]$name
#> [1] "% CPE Inhibition @ 0.391 uM"
#>
#> $descr$results[[10]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.391 uM"
#>
#> $descr$results[[10]]$type
#> [1] 1
#>
#> $descr$results[[10]]$unit
#> [1] 15
#>
#> $descr$results[[10]]$tc
#> concentration unit dr_id
#> 0.391 5.000 1.000
#>
#>
#>
#> $descr$revision
#> [1] 1
#>
#> $descr$activity_outcome_method
#> [1] 2
#>
#> $descr$dr
#> $descr$dr[[1]]
#> $descr$dr[[1]]$id
#> [1] 1
#>
#> $descr$dr[[1]]$descr
#> [1] "CR Plot Labels 1"
#>
#> $descr$dr[[1]]$dn
#> [1] "Concentration"
#>
#> $descr$dr[[1]]$rn
#> [1] "Response"
#>
#>
#>
#> $descr$grant_number
#> [1] "1R03 MH084847-01"
#>
#> $descr$project_category
#> [1] 2For concise data (e.g., active concentration readout) with additional information:
result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "concise", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: concise
#> - Identifier: 504526
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#> [1] "AID" "SID" "CID"
#> [4] "Activity Outcome" "Target Accession" "Target GeneID"
#> [7] "Activity Value [uM]" "Activity Name" "Assay Name"
#> [10] "Assay Type" "PubMed ID" "RNAi"
#>
#>
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#> [1] "504526"
#> [2] "103061373"
#> [3] "6619281"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "3.6"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#> [1] "504526"
#> [2] "103904139"
#> [3] "2971528"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "31.4"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#> [1] "504526"
#> [2] "103904144"
#> [3] "4969604"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#> [1] "504526"
#> [2] "104169543"
#> [3] "49842897"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "5.1"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#> [1] "504526"
#> [2] "104169544"
#> [3] "49842896"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "34.6"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#> [1] "504526"
#> [2] "104169545"
#> [3] "1077725"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#> [1] "504526"
#> [2] "104169546"
#> [3] "5308867"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#> [1] "504526"
#> [2] "104169547"
#> [3] "6619281"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "4.7"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#> [1] "504526"
#> [2] "104169548"
#> [3] "49842898"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "18.8"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#> [1] "504526"
#> [2] "104222567"
#> [3] "49852456"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#> [1] "504526"
#> [2] "104222568"
#> [3] "49852454"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#> [1] "504526"
#> [2] "104222569"
#> [3] "22429370"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#> [1] "504526"
#> [2] "104222570"
#> [3] "15996204"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#> [1] "504526"
#> [2] "104222571"
#> [3] "49852455"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#> [1] "504526"
#> [2] "104222572"
#> [3] "22429344"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "6.9"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#> [1] "504526"
#> [2] "109967230"
#> [3] "50897767"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "2.32"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#> [1] "504526"
#> [2] "109967231"
#> [3] "50897764"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#> [1] "504526"
#> [2] "109967232"
#> [3] "50897761"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.22"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[19]]
#> $Table$Row[[19]]$Cell
#> [1] "504526"
#> [2] "109967233"
#> [3] "50897765"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[20]]
#> $Table$Row[[20]]$Cell
#> [1] "504526"
#> [2] "109967234"
#> [3] "50897766"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[21]]
#> $Table$Row[[21]]$Cell
#> [1] "504526"
#> [2] "109967235"
#> [3] "50897759"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "3.51"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[22]]
#> $Table$Row[[22]]$Cell
#> [1] "504526"
#> [2] "109967236"
#> [3] "50897760"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[23]]
#> $Table$Row[[23]]$Cell
#> [1] "504526"
#> [2] "109967237"
#> [3] "50897763"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[24]]
#> $Table$Row[[24]]$Cell
#> [1] "504526"
#> [2] "109967238"
#> [3] "50897762"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[25]]
#> $Table$Row[[25]]$Cell
#> [1] "504526"
#> [2] "109967239"
#> [3] "50897768"
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] "50"
#> [8] "IC50"
#> [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""For dose-response curve data:
result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "doseresponse/CSV?sid=104169547,109967232", output = "CSV")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: doseresponse/CSV?sid=104169547,109967232
#> - Identifier: 504526
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> AID SID Concentration Concentration.Unit Response Response.Unit
#> 1 504526 103061373 50.000 uM 78.38 %
#> 2 504526 103061373 25.000 uM 97.50 %
#> 3 504526 103061373 12.500 uM 94.84 %
#> 4 504526 103061373 6.250 uM 95.43 %
#> 5 504526 103061373 3.125 uM 35.06 %
#> 6 504526 103061373 1.563 uM 3.21 %
#> 7 504526 103061373 0.781 uM 1.08 %
#> 8 504526 103061373 0.391 uM 0.70 %
#> 9 504526 103904139 50.000 uM 47.67 %
#> 10 504526 103904139 25.000 uM 68.41 %
#> 11 504526 103904139 12.500 uM 16.83 %
#> 12 504526 103904139 6.250 uM 2.14 %
#> 13 504526 103904139 3.125 uM 1.07 %
#> 14 504526 103904139 1.563 uM 0.93 %
#> 15 504526 103904139 0.781 uM 0.84 %
#> 16 504526 103904139 0.391 uM 0.74 %
#> 17 504526 103904144 50.000 uM 0.42 %
#> 18 504526 103904144 25.000 uM 0.56 %
#> 19 504526 103904144 12.500 uM 0.62 %
#> 20 504526 103904144 6.250 uM 0.43 %
#> 21 504526 103904144 3.125 uM 0.51 %
#> 22 504526 103904144 1.563 uM 0.38 %
#> 23 504526 103904144 0.781 uM 0.44 %
#> 24 504526 103904144 0.391 uM 0.45 %
#> 25 504526 104169543 50.000 uM 43.94 %
#> 26 504526 104169543 25.000 uM 91.27 %
#> 27 504526 104169543 12.500 uM 82.68 %
#> 28 504526 104169543 6.250 uM 66.81 %
#> 29 504526 104169543 3.125 uM 39.43 %
#> 30 504526 104169543 1.563 uM 18.27 %
#> 31 504526 104169543 0.781 uM 6.99 %
#> 32 504526 104169543 0.391 uM 4.01 %
#> 33 504526 104169544 50.000 uM 59.74 %
#> 34 504526 104169544 25.000 uM 42.48 %
#> 35 504526 104169544 12.500 uM 21.56 %
#> 36 504526 104169544 6.250 uM 8.54 %
#> 37 504526 104169544 3.125 uM 4.49 %
#> 38 504526 104169544 1.563 uM 2.69 %
#> 39 504526 104169544 0.781 uM 1.51 %
#> 40 504526 104169544 0.391 uM 0.94 %
#> 41 504526 104169545 50.000 uM 0.55 %
#> 42 504526 104169545 25.000 uM 0.69 %
#> 43 504526 104169545 12.500 uM 0.74 %
#> 44 504526 104169545 6.250 uM 0.88 %
#> 45 504526 104169545 3.125 uM 0.95 %
#> 46 504526 104169545 1.563 uM 0.78 %
#> 47 504526 104169545 0.781 uM 0.75 %
#> 48 504526 104169545 0.391 uM 0.70 %
#> 49 504526 104169546 50.000 uM 0.51 %
#> 50 504526 104169546 25.000 uM 0.51 %
#> 51 504526 104169546 12.500 uM 0.52 %
#> 52 504526 104169546 6.250 uM 0.43 %
#> 53 504526 104169546 3.125 uM 0.58 %
#> 54 504526 104169546 1.563 uM 0.46 %
#> 55 504526 104169546 0.781 uM 0.62 %
#> 56 504526 104169546 0.391 uM 0.51 %
#> 57 504526 104169547 50.000 uM 85.88 %
#> 58 504526 104169547 25.000 uM 92.21 %
#> 59 504526 104169547 12.500 uM 91.99 %
#> 60 504526 104169547 6.250 uM 78.58 %
#> 61 504526 104169547 3.125 uM 14.87 %
#> 62 504526 104169547 1.563 uM 2.15 %
#> 63 504526 104169547 0.781 uM 0.79 %
#> 64 504526 104169547 0.391 uM 0.54 %
#> 65 504526 104169548 50.000 uM 72.51 %
#> 66 504526 104169548 25.000 uM 61.24 %
#> 67 504526 104169548 12.500 uM 40.57 %
#> 68 504526 104169548 6.250 uM 19.00 %
#> 69 504526 104169548 3.125 uM 8.08 %
#> 70 504526 104169548 1.563 uM 3.66 %
#> 71 504526 104169548 0.781 uM 1.59 %
#> 72 504526 104169548 0.391 uM 1.04 %
#> 73 504526 104222567 50.000 uM 0.59 %
#> 74 504526 104222567 25.000 uM 0.77 %
#> 75 504526 104222567 12.500 uM 0.76 %
#> 76 504526 104222567 6.250 uM 0.94 %
#> 77 504526 104222567 3.125 uM 0.79 %
#> 78 504526 104222567 1.563 uM 0.80 %
#> 79 504526 104222567 0.781 uM 0.77 %
#> 80 504526 104222567 0.391 uM 0.73 %
#> 81 504526 104222568 50.000 uM 0.58 %
#> 82 504526 104222568 25.000 uM 0.54 %
#> 83 504526 104222568 12.500 uM 0.53 %
#> 84 504526 104222568 6.250 uM 0.49 %
#> 85 504526 104222568 3.125 uM 0.50 %
#> 86 504526 104222568 1.563 uM 0.39 %
#> 87 504526 104222568 0.781 uM 0.36 %
#> 88 504526 104222568 0.391 uM 0.53 %
#> 89 504526 104222569 50.000 uM 0.96 %
#> 90 504526 104222569 25.000 uM 0.98 %
#> 91 504526 104222569 12.500 uM 0.94 %
#> 92 504526 104222569 6.250 uM 0.89 %
#> 93 504526 104222569 3.125 uM 1.09 %
#> 94 504526 104222569 1.563 uM 0.98 %
#> 95 504526 104222569 0.781 uM 0.89 %
#> 96 504526 104222569 0.391 uM 0.71 %
#> 97 504526 104222570 50.000 uM 1.83 %
#> 98 504526 104222570 25.000 uM 1.50 %
#> 99 504526 104222570 12.500 uM 1.11 %
#> 100 504526 104222570 6.250 uM 0.77 %
#> 101 504526 104222570 3.125 uM 0.64 %
#> 102 504526 104222570 1.563 uM 0.51 %
#> 103 504526 104222570 0.781 uM 0.48 %
#> 104 504526 104222570 0.391 uM 0.57 %
#> 105 504526 104222571 50.000 uM 2.00 %
#> 106 504526 104222571 25.000 uM 2.18 %
#> 107 504526 104222571 12.500 uM 1.73 %
#> 108 504526 104222571 6.250 uM 1.56 %
#> 109 504526 104222571 3.125 uM 1.19 %
#> 110 504526 104222571 1.563 uM 0.93 %
#> 111 504526 104222571 0.781 uM 0.80 %
#> 112 504526 104222571 0.391 uM 0.74 %
#> 113 504526 104222572 50.000 uM 78.03 %
#> 114 504526 104222572 25.000 uM 86.65 %
#> 115 504526 104222572 12.500 uM 83.45 %
#> 116 504526 104222572 6.250 uM 47.02 %
#> 117 504526 104222572 3.125 uM 12.20 %
#> 118 504526 104222572 1.563 uM 2.23 %
#> 119 504526 104222572 0.781 uM 0.77 %
#> 120 504526 104222572 0.391 uM 0.65 %
#> 121 504526 109967230 50.000 uM 107.05 %
#> 122 504526 109967230 25.000 uM 90.78 %
#> 123 504526 109967230 12.500 uM 87.53 %
#> 124 504526 109967230 6.250 uM 101.19 %
#> 125 504526 109967230 3.125 uM 80.54 %
#> 126 504526 109967230 1.563 uM 15.81 %
#> 127 504526 109967230 0.781 uM 4.66 %
#> 128 504526 109967230 0.391 uM 2.32 %
#> 129 504526 109967231 50.000 uM 2.59 %
#> 130 504526 109967231 25.000 uM 2.63 %
#> 131 504526 109967231 12.500 uM 2.32 %
#> 132 504526 109967231 6.250 uM 2.49 %
#> 133 504526 109967231 3.125 uM 1.96 %
#> 134 504526 109967231 1.563 uM 1.80 %
#> 135 504526 109967231 0.781 uM 1.19 %
#> 136 504526 109967231 0.391 uM 1.06 %
#> 137 504526 109967232 50.000 uM 7.51 %
#> 138 504526 109967232 25.000 uM 9.47 %
#> 139 504526 109967232 12.500 uM 60.40 %
#> 140 504526 109967232 6.250 uM 79.75 %
#> 141 504526 109967232 3.125 uM 72.51 %
#> 142 504526 109967232 1.563 uM 59.35 %
#> 143 504526 109967232 0.781 uM 35.87 %
#> 144 504526 109967232 0.391 uM 13.62 %
#> 145 504526 109967233 50.000 uM 30.79 %
#> 146 504526 109967233 25.000 uM 21.08 %
#> 147 504526 109967233 12.500 uM 27.55 %
#> 148 504526 109967233 6.250 uM 17.89 %
#> 149 504526 109967233 3.125 uM 6.44 %
#> 150 504526 109967233 1.563 uM 3.41 %
#> 151 504526 109967233 0.781 uM 2.54 %
#> 152 504526 109967233 0.391 uM 1.48 %
#> 153 504526 109967234 50.000 uM 9.10 %
#> 154 504526 109967234 25.000 uM 11.20 %
#> 155 504526 109967234 12.500 uM 10.88 %
#> 156 504526 109967234 6.250 uM 7.76 %
#> 157 504526 109967234 3.125 uM 4.61 %
#> 158 504526 109967234 1.563 uM 3.29 %
#> 159 504526 109967234 0.781 uM 2.06 %
#> 160 504526 109967234 0.391 uM 1.52 %
#> 161 504526 109967235 50.000 uM 88.79 %
#> 162 504526 109967235 25.000 uM 90.14 %
#> 163 504526 109967235 12.500 uM 77.74 %
#> 164 504526 109967235 6.250 uM 66.47 %
#> 165 504526 109967235 3.125 uM 48.34 %
#> 166 504526 109967235 1.563 uM 32.20 %
#> 167 504526 109967235 0.781 uM 15.81 %
#> 168 504526 109967235 0.391 uM 5.72 %
#> 169 504526 109967236 50.000 uM 3.20 %
#> 170 504526 109967236 25.000 uM 6.08 %
#> 171 504526 109967236 12.500 uM 34.16 %
#> 172 504526 109967236 6.250 uM 17.15 %
#> 173 504526 109967236 3.125 uM 8.56 %
#> 174 504526 109967236 1.563 uM 4.66 %
#> 175 504526 109967236 0.781 uM 3.13 %
#> 176 504526 109967236 0.391 uM 1.93 %
#> 177 504526 109967237 50.000 uM 12.15 %
#> 178 504526 109967237 25.000 uM 3.83 %
#> 179 504526 109967237 12.500 uM 8.53 %
#> 180 504526 109967237 6.250 uM 39.90 %
#> 181 504526 109967237 3.125 uM 30.03 %
#> 182 504526 109967237 1.563 uM 14.27 %
#> 183 504526 109967237 0.781 uM 5.48 %
#> 184 504526 109967237 0.391 uM 3.58 %
#> 185 504526 109967238 50.000 uM 2.49 %
#> 186 504526 109967238 25.000 uM 4.66 %
#> 187 504526 109967238 12.500 uM 4.19 %
#> 188 504526 109967238 6.250 uM 3.38 %
#> 189 504526 109967238 3.125 uM 2.38 %
#> 190 504526 109967238 1.563 uM 1.70 %
#> 191 504526 109967238 0.781 uM 1.37 %
#> 192 504526 109967238 0.391 uM 1.06 %
#> 193 504526 109967239 50.000 uM 2.10 %
#> 194 504526 109967239 25.000 uM 2.52 %
#> 195 504526 109967239 12.500 uM 1.87 %
#> 196 504526 109967239 6.250 uM 1.93 %
#> 197 504526 109967239 3.125 uM 1.62 %
#> 198 504526 109967239 1.563 uM 1.42 %
#> 199 504526 109967239 0.781 uM 1.31 %
#> 200 504526 109967239 0.391 uM 1.27 %3. Targets: To retrieve assay targets, including protein or gene identifiers:
result <- get_pug_rest(identifier = c("490","1000"), namespace = "aid", domain = "assay", operation = "targets/ProteinGI,ProteinName,GeneID,GeneSymbol", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: targets/ProteinGI,ProteinName,GeneID,GeneSymbol
#> - Identifier: 490, 1000
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $InformationList
#> $InformationList$Information
#> $InformationList$Information[[1]]
#> $InformationList$Information[[1]]$AID
#> [1] 1000
#>
#> $InformationList$Information[[1]]$GI
#> [1] 116516899
#>
#> $InformationList$Information[[1]]$ProteinName
#> [1] "mevalonate kinase"To select assays via target identifier:
result <- get_pug_rest(identifier = "USP2", namespace = "target/genesymbol", domain = "assay", operation = "aids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: DomainSpecific
#> - Operation: aids
#> - Identifier: USP2
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 927
#> 2 1455
#> 3 1904
#> 4 2281
#> 5 463106
#> 6 463254
#> 7 493168
#> 8 493170
#> 9 504793
#> 10 504794
#> 11 504804
#> 12 504805
#> 13 504808
#> 14 624099
#> 15 624345
#> 16 651626
#> 17 651810
#> 18 651811
#> 19 652172
#> 20 652173
#> 21 652174
#> 22 652243
#> 23 652259
#> 24 652272
#> 25 686937
#> 26 686938
#> 27 686943
#> 28 686990
#> 29 694822
#> 30 720505
#> 31 743454
#> 32 755342
#> 33 761504
#> 34 1053208
#> 35 1117281
#> 36 1117357
#> 37 1128595
#> 38 1128604
#> 39 1159506
#> 40 1159578
#> 41 1159584
#> 42 1159615
#> 43 1197975
#> 44 1224826
#> 45 1224828
#> 46 1224830
#> 47 1383944
#> 48 1383945
#> 49 1383947
#> 50 1383948
#> 51 1383950
#> 52 1383951
#> 53 1489184
#> 54 1489185
#> 55 1491550
#> 56 1508587
#> 57 1508588
#> 58 1558721
#> 59 1561164
#> 60 1649123
#> 61 1680000
#> 62 1692429
#> 63 1794863
#> 64 1802686
#> 65 1802687
#> 66 1857650
#> 67 1881105
#> 68 1897518
#> 69 1925871
#> 70 1930792
#> 71 1930821
#> 72 1930826
#> 73 1930827
#> 74 1947415
#> 75 1947418
#> 76 1947449
#> 77 1947457
#> 78 19475244. Activity Name: To select BioAssays by the name of the primary activity column:
result <- get_pug_rest(identifier = "EC50", namespace = "activity", domain = "assay", operation = "aids", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: DomainSpecific
#> - Operation: aids
#> - Identifier: EC50
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $IdentifierList
#> $IdentifierList$AID
#> [1] 430 431 618 620 696 718 737 773 854
#> [10] 872 874 876 936 1001 1045 1047 1050 1062
#> [19] 1078 1192 1196 1197 1198 1200 1221 1222 1223
#> [28] 1224 1228 1232 1234 1241 1243 1244 1245 1247
#> [37] 1248 1252 1266 1268 1269 1270 1271 1280 1281
#> [46] 1282 1283 1287 1289 1290 1291 1292 1293 1294
#> [55] 1295 1299 1302 1319 1320 1322 1323 1324 1327
#> [64] 1328 1329 1330 1331 1333 1334 1335 1336 1337
#> [73] 1339 1340 1341 1364 1365 1366 1367 1368 1369
#> [82] 1370 1371 1372 1373 1374 1375 1394 1397 1404
#> [91] 1406 1412 1414 1442 1444 1450 1465 1470 1508
#> [100] 1522 1528 1538 1562 1566 1578 1625 1659 1660
#> [109] 1679 1681 1682 1684 1686 1689 1690 1701 1723
#> [118] 1735 1736 1737 1738 1743 1744 1753 1757 1764
#> [127] 1767 1769 1777 1871 1872 1884 1888 1889 1891
#> [136] 1895 1896 1897 1900 1902 1914 1915 1923 1928
#> [145] 1929 1930 1932 1933 1934 1935 1936 1938 1939
#> [154] 1959 1960 1961 1964 1966 1988 1990 1994 1999
#> [163] 2002 2003 2008 2009 2010 2019 2020 2021 2022
#> [172] 2027 2031 2033 2036 2037 2038 2039 2040 2041
#> [181] 2042 2043 2044 2045 2046 2047 2048 2050 2051
#> [190] 2053 2055 2075 2077 2080 2081 2084 2086 2089
#> [199] 2096 2102 2121 2124 2133 2137 2138 2145 2150
#> [208] 2151 2181 2182 2183 2185 2186 2188 2190 2191
#> [217] 2192 2193 2194 2197 2199 2207 2208 2209 2210
#> [226] 2211 2212 2219 2220 2224 2252 2253 2284 2286
#> [235] 2294 2295 2296 2298 2307 2310 2311 2327 2343
#> [244] 2344 2347 2352 2359 2370 2376 2382 2387 2388
#> [253] 2396 2398 2400 2423 2425 2428 2434 2438 2442
#> [262] 2443 2446 2450 2452 2453 2454 2456 2457 2458
#> [271] 2460 2463 2467 2468 2470 2471 2473 2477 2484
#> [280] 2486 2492 2493 2497 2500 2510 2511 2518 2519
#> [289] 2525 2548 2583 2586 2603 2607 2608 2609 2610
#> [298] 2611 2630 2631 2633 2635 2638 2651 2654 2670
#> [307] 2683 2696 2704 2723 2724 2725 2735 2738 2739
#> [316] 2740 2742 2743 2744 2745 2753 2765 2807 2809
#> [325] 2814 2821 2823 2826 2827 2828 2829 2835 2843
#> [334] 2844 2901 2996 2997 2999 3004 3005 3006 3008
#> [343] 3009 3015 3058 3059 3189 3385 3423 3490 3492
#> [352] 3502 3503 3506 3507 3508 3509 3510 3513 3516
#> [361] 3517 3519 3706 3709 3901 3902 3903 3904 3905
#> [370] 3906 3907 3909 4494 4495 4496 4497 4498 4499
#> [379] 4500 4501 4502 4520 4521 4550 4567 4571 4572
#> [388] 4573 4574 4575 4576 4577 4578 4579 4580 4581
#> [397] 4582 4666 4667 4779 4871 4872 4936 4937 4938
#> [406] 4939 4972 4973 4974 5161 5162 5163 5165 5383
#> [415] 5459 5460 5461 5462 5464 5465 5466 5467 5468
#> [424] 5702 5841 5842 5843 6140 6142 6147 6148 6209
#> [433] 6220 6224 6225 6226 6228 6229 6250 6267 6274
#> [442] 6275 6276 6377 6380 6398 6399 8455 8619 8848
#> [451] 8849 9404 9405 9448 9454 9465 9467 9468 9635
#> [460] 9809 9810 9811 9812 9813 10054 19923 30287 30288
#> [469] 30289 30291 30292 30293 30294 30295 30296 30481 30504
#> [478] 30505 30506 30507 30508 30509 30510 30630 30631 30632
#> [487] 30633 30634 30792 30816 30817 30818 31103 31131 31260
#> [496] 31261 31262 31264 31265 31266 31267 31268 31269 31447
#> [505] 31454 31829 32070 32145 32146 32147 32148 32149 32150
#> [514] 32151 32464 32465 32785 32836 32967 32970 32972 33156
#> [523] 33162 33163 33164 33505 33767 33768 33769 33770 33950
#> [532] 34073 34074 34264 34265 34266 34267 34268 34269 34270
#> [541] 34309 34436 34438 34439 34440 34584 34592 34594 34596
#> [550] 34598 34600 34747 34748 35160 35381 35384 35390 35445
#> [559] 35446 35447 35448 35449 35451 35452 35453 35586 35618
#> [568] 35832 35922 35956 35957 35958 35959 35985 35987 35988
#> [577] 35989 35990 35991 35992 35993 35994 36027 36045 36046
#> [586] 36065 36133 36134 36135 36232 36233 36246 36261 36262
#> [595] 36352 36385 36416 36417 36419 36420 36421 36434 36435
#> [604] 36436 36437 36470 36512 36513 36524 36525 36526 36527
#> [613] 36578 36579 36580 36581 36626 36627 36628 36629 36656
#> [622] 36657 36665 36674 36675 36682 36683 36763 37036 37345
#> [631] 37346 37347 37348 37349 37350 37497 38017 38035 38326
#> [640] 38516 38518 38519 38533 38534 38535 38600 38694 38695
#> [649] 38696 38742 38799 38801 38802 38803 38804 38805 39027
#> [658] 39064 39165 39218 39867 39967 39968 40109 40110 40111
#> [667] 40112 40114 40115 40116 40117 40118 40119 40121 40122
#> [676] 40126 40844 40846 41017 41018 41032 41036 41037 41039
#> [685] 41040 41041 41045 41130 41137 41159 41160 41161 41162
#> [694] 41163 41165 41198 41199 41204 41207 41441 41442 41445
#> [703] 41512 41513 41528 41529 41530 41531 41543 41569 41570
#> [712] 41592 41600 41601 41634 41636 41650 41651 41652 41653
#> [721] 41654 41655 41656 41657 41658 41660 41663 41664 41665
#> [730] 41666 41667 41668 41669 41777 41778 41779 41780 41781
#> [739] 41783 41785 41786 41788 41789 41790 41791 41792 41910
#> [748] 41937 41938 41939 41940 41941 41964 42046 42047 42048
#> [757] 42049 42050 42052 42053 42092 42107 42117 42122 42220
#> [766] 42231 42233 42359 42382 42383 42398 42399 42593 42620
#> [775] 42621 42622 42776 42777 42778 42831 42847 42899 43083
#> [784] 43236 43237 43238 43239 43240 43241 43385 43386 43387
#> [793] 43388 43389 43390 43391 43392 43393 43394 43395 43396
#> [802] 43397 43398 43978 43979 43986 43987 43988 43990 44004
#> [811] 44005 44006 44208 44209 44211 44212 44213 44214 44215
#> [820] 44216 44217 44235 44340 44352 44384 44385 44393 44394
#> [829] 44398 44399 44405 44411 44412 44541 44542 44545 44546
#> [838] 44553 44560 44562 44563 44569 44570 44571 44591 44604
#> [847] 44608 44610 44627 44631 44641 44642 44645 44646 44647
#> [856] 44664 44665 44666 44667 44668 44669 44719 44735 44737
#> [865] 44739 44740 44741 44789 44790 44791 44792 44793 44794
#> [874] 44795 44796 44814 44816 44817 44818 44819 44820 44821
#> [883] 44822 44823 44824 44825 44826 44827 44828 44829 44830
#> [892] 44831 44832 44874 44998 44999 45000 45001 45002 45003
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#> [19324] 1140319 1140320 1140321 1140322 1140323 1140324 1140325 1140326 1140327
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#> [19360] 1141940 1141960 1141962 1141963 1141964 1141965 1141966 1141967 1141968
#> [19369] 1142031 1142106 1142108 1142112 1142113 1142114 1142196 1142221 1142222
#> [19378] 1142223 1142339 1142340 1142357 1142358 1142359 1142360 1142361 1142362
#> [19387] 1142363 1142383 1143097 1143099 1143100 1143101 1143102 1143103 1143104
#> [19396] 1143189 1143201 1143321 1143328 1143459 1143461 1143726 1143727 1143733
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#> [19414] 1151520 1151521 1151522 1151523 1151524 1151525 1151526 1151527 1151540
#> [19423] 1151542 1151544 1151546 1151548 1151833 1151835 1151911 1151916 1151918
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#> [19657] 1160770 1160774 1160775 1160776 1160777 1160778 1160779 1160780 1160781
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#> [19747] 1163233 1163312 1163313 1163346 1163514 1163529 1164163 1164219 1164344
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#> [21304] 1238217 1238220 1238313 1238314 1238315 1238316 1238317 1238321 1238323
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#> [38476] 1951541 1951639 1951642 1951645 1951648 1951651 1951654 1951657 1951660
#> [38485] 1951663 1951666 1951669 1951672 1951675 1951975 1951977 1952154 1952157
#> [38494] 1952162 1952163 1952166 1952168 1952173 1952174 1952176 1952177 1952452
#> [38503] 1952454 1952676 1952677 1952678 1952679 1952680 1952681 1952682 1952683
#> [38512] 1952684 1952685 1952686 1952687 1952689 1952697 1952698 1952699 1952700
#> [38521] 1952716 1952815 1952831 1952834 1952862 1952916 1952945 1952949 1953300
#> [38530] 1953301 1953311 1953332 1953411 1953412 1953584 1953609 1953610 1953611
#> [38539] 1953612 1953728 1953745 1953746 1953749 1953752 1953753 1953754 1953755
#> [38548] 1953756 1953768 1953769 1953770 1953771 1953788 1953792 1953797 1953801
#> [38557] 1953803 1953812 1953814 1953818 1953820 1953824 1954051 1954052 1954053
#> [38566] 1954063 1954064 1954065 1954066 1954067 1954068 1954069 1954070 1954071
#> [38575] 1954075 1954080 1954081 1954087 1954090 1954091 1954092 1954097 1954098
#> [38584] 1954100 1954103 1954104 1954112 1954114 1954225 1954226 1954227 1954228
#> [38593] 1954229 1954230 1954231 1954232 1954233 1954235 1954237 1954327 1954328
#> [38602] 1954581 1954676 1954679 1954680 1954682 1954826 1954828 1954846 1954854
#> [38611] 1954856 1954857 1954858 1954861 1955045 1955063 1955065 1955068 1955069
#> [38620] 1955071 1955078 1955079 1955080 1955081 1955082 1955440 1955486 1955487
#> [38629] 1955488 1955489 1955490 1955491 1955492 1955493 1955495 1955496 1955504
#> [38638] 1955505 1955510 1955511 1955516 1955517 1955522 1955523 1955524 1955525
#> [38647] 1955532 1955534 1955538 1955539 1955540 1955541 1955542 1955543 1955544
#> [38656] 1955545 1955557 1955570 1955571 1955572 1955576 1955577 1955578 1955579
#> [38665] 1955580 1955581 1955582 1955583 1955584 1955585 1955586 1955587 1955635
#> [38674] 1955642 1955643 1955644 1955820 1956008 1956114 1956116 1956124 1956127
#> [38683] 1956131 1956134 1956257 1956347 1956348 1956458 1956459 1956460 1956473
#> [38692] 1956510 1956641 1956642 1956643 1956644 1956645 1956646 1956647 1956648
#> [38701] 1956649 1956650 1956651 1956819 1957003 1957006 1957007 1957013 1957046
#> [38710] 1957056 1957087 1957156 1957195 1957224 1957225 1957226 1957227 1957228
#> [38719] 1957229 1957230 1957231 1957249 1957250 1957290 1957439 1957528 1957532
#> [38728] 1957533 1957543 1959096 1959123 1959169 1959170 1959182 1959184 1959185
#> [38737] 1959186 1959356 1959375 1959380 1959556 1959679 1959700 1959701 1959768
#> [38746] 1959769 1959771 1959794 1959913 1959914 1959916 1959917 1959918 1959919
#> [38755] 1960099 1960105 1960107 1960417 1960449 1960450 1960455 1960456 1960457
#> [38764] 1960458 1960581 1960582 1960583 1960710 1960724 1960918 1960919 1960920
#> [38773] 1960921 1960922 1960923 1960924 1960925 1960926 1960927 1960928 1960929
#> [38782] 1960930 1960931 1960935 1960938 1960940 1960941 1960942 1961203 1961347
#> [38791] 1961349 1961531 1961606 1961607 1961608 1961609 1961611 1961614 1961617
#> [38800] 1961619 1961622 1961648 1962465 1963009 1963010 1963012 1963014 1963016
#> [38809] 1963018 1963020 1963022 1963024 1963026 1963028 1963030 1963032 1963034
#> [38818] 1963036 1963038 1963040 1963042 1963044 1963046 1963048 1963050 1963052
#> [38827] 1963054 1963056 1963060 1963063 1963065 1963067 1963070 1963075 1963077
#> [38836] 1963116 1963117 1963118 1963119 1963120 1963121 1963122 1963124 1963126
#> [38845] 1963128 1963130 1963132 1963134 1963136 1963138 1963140 1963146 1963155
#> [38854] 1963157 1963163 1963165 1963171 1963174 1963176 1963178 1963180 1963182
#> [38863] 1963184 1963186 1963187 1963189 1963191 1963195 1963196 1963198 1963205
#> [38872] 1963207 1963213 1963214 1963219 1963222 1963224 1963226 1963228 1963230
#> [38881] 1963232 1963234 1963235 1963237 1963239 1963243 1963244 1963246 1963253
#> [38890] 1963255 1963262 1963263 1963268 1963287 1963288 1963326 1963327 1963328
#> [38899] 1963329 1963330 1963331 1963332 1963333 1963337 1963341 1963352 1963353
#> [38908] 1963354 1963370 1963383 1963386 1963395 1963396 1963398 1963401 1963402
#> [38917] 1963405 1963407 1963408 1963409 1963459 1963461 1963462 1963463 1963464
#> [38926] 1963468 1963471 1963473 1963474 1963475 1963480 1963506 1963528 1963534
#> [38935] 1963539 1963599 1963623These examples demonstrate the flexibility of PUG REST in accessing specific BioAssay data. Users can efficiently retrieve detailed descriptions, comprehensive data sets, concise readouts, and target information, making it a valuable tool for researchers and scientists working with BioAssay data.
PubChem provides various methods to access gene data, making it a valuable resource for genetic research. Here’s how you can utilize PUG REST to access gene-related information:
1. Gene Input Methods:
result <- get_pug_rest(identifier = "1956,13649", namespace = "geneid", domain = "gene", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: 1956,13649
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#>
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#>
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#>
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#> [1] "ERBB"
#> [2] "ERBB1"
#> [3] "ERRP"
#> [4] "HER1"
#> [5] "NISBD2"
#> [6] "NNCIS"
#> [7] "PIG61"
#> [8] "mENA"
#> [9] "EGFR vIII"
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"
#> [12] "cell proliferation-inducing protein 61"
#> [13] "epidermal growth factor receptor tyrosine kinase domain"
#> [14] "erb-b2 receptor tyrosine kinase 1"
#> [15] "proto-oncogene c-ErbB-1"
#> [16] "receptor tyrosine-protein kinase erbB-1"
#>
#>
#> $GeneSummaries$GeneSummary[[2]]
#> $GeneSummaries$GeneSummary[[2]]$GeneID
#> [1] 13649
#>
#> $GeneSummaries$GeneSummary[[2]]$Symbol
#> [1] "Egfr"
#>
#> $GeneSummaries$GeneSummary[[2]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[2]]$TaxonomyID
#> [1] 10090
#>
#> $GeneSummaries$GeneSummary[[2]]$Taxonomy
#> [1] "Mus musculus (house mouse)"
#>
#> $GeneSummaries$GeneSummary[[2]]$Description
#> [1] ""
#>
#> $GeneSummaries$GeneSummary[[2]]$Synonym
#> [1] "9030024J15Rik"
#> [2] "Erbb"
#> [3] "Errb1"
#> [4] "Errp"
#> [5] "Wa5"
#> [6] "wa-2"
#> [7] "wa2"
#> [8] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [9] "waved 2"result <- get_pug_rest(identifier = "EGFR", namespace = "genesymbol", domain = "gene", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: EGFR
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#>
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#>
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#>
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#> [1] "ERBB"
#> [2] "ERBB1"
#> [3] "ERRP"
#> [4] "HER1"
#> [5] "NISBD2"
#> [6] "NNCIS"
#> [7] "PIG61"
#> [8] "mENA"
#> [9] "EGFR vIII"
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"
#> [12] "cell proliferation-inducing protein 61"
#> [13] "epidermal growth factor receptor tyrosine kinase domain"
#> [14] "erb-b2 receptor tyrosine kinase 1"
#> [15] "proto-oncogene c-ErbB-1"
#> [16] "receptor tyrosine-protein kinase erbB-1"result <- get_pug_rest(identifier = "ERBB1", namespace = "synonym", domain = "gene", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: ERBB1
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#>
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#>
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#>
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#> [1] "ERBB"
#> [2] "ERBB1"
#> [3] "ERRP"
#> [4] "HER1"
#> [5] "NISBD2"
#> [6] "NNCIS"
#> [7] "PIG61"
#> [8] "mENA"
#> [9] "EGFR vIII"
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"
#> [12] "cell proliferation-inducing protein 61"
#> [13] "epidermal growth factor receptor tyrosine kinase domain"
#> [14] "erb-b2 receptor tyrosine kinase 1"
#> [15] "proto-oncogene c-ErbB-1"
#> [16] "receptor tyrosine-protein kinase erbB-1"
#>
#>
#> $GeneSummaries$GeneSummary[[2]]
#> $GeneSummaries$GeneSummary[[2]]$GeneID
#> [1] 24329
#>
#> $GeneSummaries$GeneSummary[[2]]$Symbol
#> [1] "Egfr"
#>
#> $GeneSummaries$GeneSummary[[2]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[2]]$TaxonomyID
#> [1] 10116
#>
#> $GeneSummaries$GeneSummary[[2]]$Taxonomy
#> [1] "Rattus norvegicus (Norway rat)"
#>
#> $GeneSummaries$GeneSummary[[2]]$Description
#> [1] "promotes cell proliferation and differentiation; mediates GPCR regulated induction of protein synthesis [RGD, Feb 2006]"
#>
#> $GeneSummaries$GeneSummary[[2]]$Synonym
#> [1] "ERBB1"
#> [2] "ErbB-1"
#> [3] "Errp"
#> [4] "EGFR-related peptide"
#> [5] "Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)"
#> [6] "avian erythroblastic leukemia viral (v-erbB) oncogene homolog"
#> [7] "epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)"
#>
#>
#> $GeneSummaries$GeneSummary[[3]]
#> $GeneSummaries$GeneSummary[[3]]$GeneID
#> [1] 724072
#>
#> $GeneSummaries$GeneSummary[[3]]$Symbol
#> [1] "egfr.L"
#>
#> $GeneSummaries$GeneSummary[[3]]$Name
#> [1] "epidermal growth factor receptor L homeolog"
#>
#> $GeneSummaries$GeneSummary[[3]]$TaxonomyID
#> [1] 8355
#>
#> $GeneSummaries$GeneSummary[[3]]$Taxonomy
#> [1] "Xenopus laevis (African clawed frog)"
#>
#> $GeneSummaries$GeneSummary[[3]]$Description
#> [1] ""
#>
#> $GeneSummaries$GeneSummary[[3]]$Synonym
#> [1] "XEgfr" "egfr"
#> [3] "erbb" "erbb1"
#> [5] "her1" "epidermal growth factor receptor"
#>
#>
#> $GeneSummaries$GeneSummary[[4]]
#> $GeneSummaries$GeneSummary[[4]]$GeneID
#> [1] 100492965
#>
#> $GeneSummaries$GeneSummary[[4]]$Symbol
#> [1] "egfr"
#>
#> $GeneSummaries$GeneSummary[[4]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[4]]$TaxonomyID
#> [1] 8364
#>
#> $GeneSummaries$GeneSummary[[4]]$Taxonomy
#> [1] "Xenopus tropicalis (tropical clawed frog)"
#>
#> $GeneSummaries$GeneSummary[[4]]$Description
#> [1] ""
#>
#> $GeneSummaries$GeneSummary[[4]]$Synonym
#> [1] "XEgfr" "erbb" "erbb1" "her1"
#>
#>
#> $GeneSummaries$GeneSummary[[5]]
#> $GeneSummaries$GeneSummary[[5]]$GeneID
#> [1] 100537376
#>
#> $GeneSummaries$GeneSummary[[5]]$Symbol
#> [1] "egfrb"
#>
#> $GeneSummaries$GeneSummary[[5]]$Name
#> [1] "epidermal growth factor receptor b (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)"
#>
#> $GeneSummaries$GeneSummary[[5]]$TaxonomyID
#> [1] 7955
#>
#> $GeneSummaries$GeneSummary[[5]]$Taxonomy
#> [1] "Danio rerio (zebrafish)"
#>
#> $GeneSummaries$GeneSummary[[5]]$Description
#> [1] ""
#>
#> $GeneSummaries$GeneSummary[[5]]$Synonym
#> [1] "erbb1" "erbb1b"
#>
#>
#> $GeneSummaries$GeneSummary[[6]]
#> $GeneSummaries$GeneSummary[[6]]$GeneID
#> [1] 108719997
#>
#> $GeneSummaries$GeneSummary[[6]]$Symbol
#> [1] "egfr.S"
#>
#> $GeneSummaries$GeneSummary[[6]]$Name
#> [1] "epidermal growth factor receptor S homeolog"
#>
#> $GeneSummaries$GeneSummary[[6]]$TaxonomyID
#> [1] 8355
#>
#> $GeneSummaries$GeneSummary[[6]]$Taxonomy
#> [1] "Xenopus laevis (African clawed frog)"
#>
#> $GeneSummaries$GeneSummary[[6]]$Description
#> [1] ""
#>
#> $GeneSummaries$GeneSummary[[6]]$Synonym
#> [1] "XEgfr" "erbb"
#> [3] "erbb1" "her1"
#> [5] "epidermal growth factor receptor"2. Available Gene Data:
result <- get_pug_rest(identifier = "1956,13649", namespace = "geneid", domain = "gene", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: 1956,13649
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#>
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#>
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#>
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#> [1] "ERBB"
#> [2] "ERBB1"
#> [3] "ERRP"
#> [4] "HER1"
#> [5] "NISBD2"
#> [6] "NNCIS"
#> [7] "PIG61"
#> [8] "mENA"
#> [9] "EGFR vIII"
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"
#> [12] "cell proliferation-inducing protein 61"
#> [13] "epidermal growth factor receptor tyrosine kinase domain"
#> [14] "erb-b2 receptor tyrosine kinase 1"
#> [15] "proto-oncogene c-ErbB-1"
#> [16] "receptor tyrosine-protein kinase erbB-1"
#>
#>
#> $GeneSummaries$GeneSummary[[2]]
#> $GeneSummaries$GeneSummary[[2]]$GeneID
#> [1] 13649
#>
#> $GeneSummaries$GeneSummary[[2]]$Symbol
#> [1] "Egfr"
#>
#> $GeneSummaries$GeneSummary[[2]]$Name
#> [1] "epidermal growth factor receptor"
#>
#> $GeneSummaries$GeneSummary[[2]]$TaxonomyID
#> [1] 10090
#>
#> $GeneSummaries$GeneSummary[[2]]$Taxonomy
#> [1] "Mus musculus (house mouse)"
#>
#> $GeneSummaries$GeneSummary[[2]]$Description
#> [1] ""
#>
#> $GeneSummaries$GeneSummary[[2]]$Synonym
#> [1] "9030024J15Rik"
#> [2] "Erbb"
#> [3] "Errb1"
#> [4] "Errp"
#> [5] "Wa5"
#> [6] "wa-2"
#> [7] "wa2"
#> [8] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [9] "waved 2"result <- get_pug_rest(identifier = "13649", namespace = "geneid", domain = "gene", operation = "aids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: aids
#> - Identifier: 13649
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 66438
#> 2 69721
#> 3 69722
#> 4 69724
#> 5 69727
#> 6 69728
#> 7 69729
#> 8 69730
#> 9 106697
#> 10 209326
#> 11 241562
#> 12 241823
#> 13 337238
#> 14 337243
#> 15 337244
#> 16 415757
#> 17 415758
#> 18 415759
#> 19 415760
#> 20 1053208
#> 21 1224826
#> 22 1224828
#> 23 1527521
#> 24 1740135
#> 25 1815786
#> 26 1815820
#> 27 1862914
#> 28 1896806result <- get_pug_rest(identifier = "13649", namespace = "geneid", domain = "gene", operation = "concise", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: concise
#> - Identifier: 13649
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#> [1] "AID" "SID" "CID"
#> [4] "Activity Outcome" "Target Accession" "Activity Value [uM]"
#> [7] "Activity Name" "Assay Name" "Assay Type"
#> [10] "PubMed ID" "RNAi"
#>
#>
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#> [1] "66438"
#> [2] "103250953"
#> [3] "25017867"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.01"
#> [7] "Effective concentration"
#> [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#> [9] "Confirmatory"
#> [10] "1597853"
#> [11] ""
#>
#>
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#> [1] "66438"
#> [2] "103432098"
#> [3] "454217"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.22"
#> [7] "Effective concentration"
#> [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#> [9] "Confirmatory"
#> [10] "1597853"
#> [11] ""
#>
#>
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#> [1] "69721"
#> [2] "103358917"
#> [3] "135512509"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "22.7"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#> [9] "Confirmatory"
#> [10] "9748366"
#> [11] ""
#>
#>
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#> [1] "69721"
#> [2] "103358918"
#> [3] "135434086"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "36.9"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#> [9] "Confirmatory"
#> [10] "9748366"
#> [11] ""
#>
#>
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#> [1] "69721"
#> [2] "103358919"
#> [3] "135455949"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "11.3"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#> [9] "Confirmatory"
#> [10] "9748366"
#> [11] ""
#>
#>
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#> [1] "69722"
#> [2] "103253186"
#> [3] "5328592"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#> [11] ""
#>
#>
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#> [1] "69722"
#> [2] "103253755"
#> [3] "5328614"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#> [11] ""
#>
#>
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#> [1] "69722"
#> [2] "103254313"
#> [3] "5328618"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#> [11] ""
#>
#>
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#> [1] "69722"
#> [2] "103254592"
#> [3] "5328617"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "25"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#> [11] ""
#>
#>
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#> [1] "69724"
#> [2] "103237764"
#> [3] "5328042"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.04"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#> [1] "69724"
#> [2] "103373305"
#> [3] "9882519"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.2"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#> [1] "69724"
#> [2] "103373788"
#> [3] "9885081"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.07"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#> [1] "69724"
#> [2] "103399645"
#> [3] "11198415"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.578"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#> [1] "69724"
#> [2] "103399736"
#> [3] "10094127"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.13"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#> [1] "69724"
#> [2] "103399893"
#> [3] "11349700"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.11"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#> [1] "69727"
#> [2] "103167027"
#> [3] "5280343"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#> [9] "Other"
#> [10] "8201603"
#> [11] ""
#>
#>
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#> [1] "69728"
#> [2] "103399857"
#> [3] "44368090"
#> [4] "Inactive"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK) (inactive)"
#> [9] "Other"
#> [10] "14640561"
#> [11] ""
#>
#>
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#> [1] "69729"
#> [2] "103167027"
#> [3] "5280343"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#> [9] "Other"
#> [10] "8201603"
#> [11] ""
#>
#>
#> $Table$Row[[19]]
#> $Table$Row[[19]]$Cell
#> [1] "69730"
#> [2] "103226434"
#> [3] "10318571"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "4"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[20]]
#> $Table$Row[[20]]$Cell
#> [1] "69730"
#> [2] "103350640"
#> [3] "10406106"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "14"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[21]]
#> $Table$Row[[21]]$Cell
#> [1] "69730"
#> [2] "103378973"
#> [3] "10738302"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "33"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[22]]
#> $Table$Row[[22]]$Cell
#> [1] "69730"
#> [2] "103378974"
#> [3] "10761144"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "200"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[23]]
#> $Table$Row[[23]]$Cell
#> [1] "69730"
#> [2] "103379003"
#> [3] "10044189"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "500"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[24]]
#> $Table$Row[[24]]$Cell
#> [1] "69730"
#> [2] "103379199"
#> [3] "10428841"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "8"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[25]]
#> $Table$Row[[25]]$Cell
#> [1] "69730"
#> [2] "103379200"
#> [3] "10716388"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[26]]
#> $Table$Row[[26]]$Cell
#> [1] "69730"
#> [2] "103379360"
#> [3] "10452792"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "50"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[27]]
#> $Table$Row[[27]]$Cell
#> [1] "69730"
#> [2] "103379591"
#> [3] "10620637"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "300"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[28]]
#> $Table$Row[[28]]$Cell
#> [1] "69730"
#> [2] "103379616"
#> [3] "10593843"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[29]]
#> $Table$Row[[29]]$Cell
#> [1] "69730"
#> [2] "103379617"
#> [3] "10787405"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "4"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[30]]
#> $Table$Row[[30]]$Cell
#> [1] "69730"
#> [2] "103379660"
#> [3] "10343317"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "35"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[31]]
#> $Table$Row[[31]]$Cell
#> [1] "69730"
#> [2] "103379661"
#> [3] "10499929"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "15"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[32]]
#> $Table$Row[[32]]$Cell
#> [1] "69730"
#> [2] "103379682"
#> [3] "10500718"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "1"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[33]]
#> $Table$Row[[33]]$Cell
#> [1] "69730"
#> [2] "103379908"
#> [3] "10619651"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[34]]
#> $Table$Row[[34]]$Cell
#> [1] "69730"
#> [2] "103379909"
#> [3] "10504027"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "35"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[35]]
#> $Table$Row[[35]]$Cell
#> [1] "69730"
#> [2] "103379910"
#> [3] "10740438"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "46"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#> [11] ""
#>
#>
#> $Table$Row[[36]]
#> $Table$Row[[36]]$Cell
#> [1] "106697"
#> [2] "103166113"
#> [3] "10499619"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "9.55"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[37]]
#> $Table$Row[[37]]$Cell
#> [1] "106697"
#> [2] "103166157"
#> [3] "9978638"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "4.93"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[38]]
#> $Table$Row[[38]]$Cell
#> [1] "106697"
#> [2] "103166217"
#> [3] "10590515"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "45.2"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[39]]
#> $Table$Row[[39]]$Cell
#> [1] "106697"
#> [2] "103166266"
#> [3] "10803234"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10.2"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[40]]
#> $Table$Row[[40]]$Cell
#> [1] "106697"
#> [2] "103166322"
#> [3] "2051"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.1"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[41]]
#> $Table$Row[[41]]$Cell
#> [1] "106697"
#> [2] "103166323"
#> [3] "10850934"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "16"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[42]]
#> $Table$Row[[42]]$Cell
#> [1] "106697"
#> [2] "103166405"
#> [3] "9883384"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "2.83"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[43]]
#> $Table$Row[[43]]$Cell
#> [1] "106697"
#> [2] "103166415"
#> [3] "10494548"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "11.4"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[44]]
#> $Table$Row[[44]]$Cell
#> [1] "106697"
#> [2] "103166416"
#> [3] "689033"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "46.2"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#> [11] ""
#>
#>
#> $Table$Row[[45]]
#> $Table$Row[[45]]$Cell
#> [1] "209326"
#> [2] "103257455"
#> [3] "2428"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.046"
#> [7] "IC50"
#> [8] "Inhibition of EGF-mediated mitogenesis in Swiss 3T3 cells"
#> [9] "Confirmatory"
#> [10] "8632415"
#> [11] ""
#>
#>
#> $Table$Row[[46]]
#> $Table$Row[[46]]$Cell
#> [1] "241562"
#> [2] "103439646"
#> [3] "10209082"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[47]]
#> $Table$Row[[47]]$Cell
#> [1] "241562"
#> [2] "103439659"
#> [3] "10185160"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[48]]
#> $Table$Row[[48]]$Cell
#> [1] "241562"
#> [2] "103439663"
#> [3] "10143584"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[49]]
#> $Table$Row[[49]]$Cell
#> [1] "241562"
#> [2] "103439672"
#> [3] "10163439"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[50]]
#> $Table$Row[[50]]$Cell
#> [1] "241562"
#> [2] "103439700"
#> [3] "10302405"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[51]]
#> $Table$Row[[51]]$Cell
#> [1] "241562"
#> [2] "103439717"
#> [3] "10187378"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[52]]
#> $Table$Row[[52]]$Cell
#> [1] "241562"
#> [2] "123092436"
#> [3] "44259"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#> [11] ""
#>
#>
#> $Table$Row[[53]]
#> $Table$Row[[53]]$Cell
#> [1] "241823"
#> [2] "103452251"
#> [3] "22732319"
#> [4] "Inconclusive"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of Epidermal growth factor receptor tyrosine kinase activity; not tested"
#> [9] "Other"
#> [10] "15454232"
#> [11] ""
#>
#>
#> $Table$Row[[54]]
#> $Table$Row[[54]]$Cell
#> [1] "337238"
#> [2] "103194285"
#> [3] "4075"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[55]]
#> $Table$Row[[55]]$Cell
#> [1] "337238"
#> [2] "103227545"
#> [3] "5328552"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[56]]
#> $Table$Row[[56]]$Cell
#> [1] "337238"
#> [2] "103319670"
#> [3] "3894"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[57]]
#> $Table$Row[[57]]$Cell
#> [1] "337238"
#> [2] "103319671"
#> [3] "3896"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[58]]
#> $Table$Row[[58]]$Cell
#> [1] "337238"
#> [2] "103529702"
#> [3] "65083"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[59]]
#> $Table$Row[[59]]$Cell
#> [1] "337238"
#> [2] "103529722"
#> [3] "70949"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[60]]
#> $Table$Row[[60]]$Cell
#> [1] "337238"
#> [2] "103618685"
#> [3] "3895"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[61]]
#> $Table$Row[[61]]$Cell
#> [1] "337238"
#> [2] "103618686"
#> [3] "44593598"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[62]]
#> $Table$Row[[62]]$Cell
#> [1] "337238"
#> [2] "103618687"
#> [3] "44593599"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[63]]
#> $Table$Row[[63]]$Cell
#> [1] "337238"
#> [2] "103618691"
#> [3] "375472"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[64]]
#> $Table$Row[[64]]$Cell
#> [1] "337238"
#> [2] "123092436"
#> [3] "44259"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[65]]
#> $Table$Row[[65]]$Cell
#> [1] "337243"
#> [2] "103319670"
#> [3] "3894"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR using [32P]gammaATP as substrate by competitive Lineweaver-Burke plot"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[66]]
#> $Table$Row[[66]]$Cell
#> [1] "337244"
#> [2] "103319670"
#> [3] "3894"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR using tridecapeptide as substrate by uncompetitive Lineweaver-Burke plot"
#> [9] "Other"
#> [10] "2614420"
#> [11] ""
#>
#>
#> $Table$Row[[67]]
#> $Table$Row[[67]]$Cell
#> [1] "415757"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[68]]
#> $Table$Row[[68]]$Cell
#> [1] "415757"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[69]]
#> $Table$Row[[69]]$Cell
#> [1] "415758"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[70]]
#> $Table$Row[[70]]$Cell
#> [1] "415758"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[71]]
#> $Table$Row[[71]]$Cell
#> [1] "415759"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[72]]
#> $Table$Row[[72]]$Cell
#> [1] "415759"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[73]]
#> $Table$Row[[73]]$Cell
#> [1] "415760"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Inactive"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[74]]
#> $Table$Row[[74]]$Cell
#> [1] "415760"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Inactive"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#> [9] "Other"
#> [10] "9139660"
#> [11] ""
#>
#>
#> $Table$Row[[75]]
#> $Table$Row[[75]]$Cell
#> [1] "1053208"
#> [2] "152302885"
#> [3] ""
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] ""
#> [8] "A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen"
#> [9] "Screening"
#> [10] "25862761"
#> [11] "1"
#>
#>
#> $Table$Row[[76]]
#> $Table$Row[[76]]$Cell
#> [1] "1224826"
#> [2] "315466459"
#> [3] ""
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] ""
#> [8] "Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout"
#> [9] "Summary"
#> [10] ""
#> [11] "1"
#>
#>
#> $Table$Row[[77]]
#> $Table$Row[[77]]$Cell
#> [1] "1224828"
#> [2] "315466459"
#> [3] ""
#> [4] "Inactive"
#> [5] ""
#> [6] ""
#> [7] ""
#> [8] "Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout"
#> [9] "Summary"
#> [10] ""
#> [11] "1"
#>
#>
#> $Table$Row[[78]]
#> $Table$Row[[78]]$Cell
#> [1] "1527521"
#> [2] "312367127"
#> [3] "71496458"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.081"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[79]]
#> $Table$Row[[79]]$Cell
#> [1] "1527521"
#> [2] "440110169"
#> [3] "139593669"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[80]]
#> $Table$Row[[80]]$Cell
#> [1] "1527521"
#> [2] "440119817"
#> [3] "155517202"
#> [4] "Inconclusive"
#> [5] "Q01279"
#> [6] ""
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[81]]
#> $Table$Row[[81]]$Cell
#> [1] "1527521"
#> [2] "440125045"
#> [3] "139447864"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "3.6"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[82]]
#> $Table$Row[[82]]$Cell
#> [1] "1527521"
#> [2] "440160302"
#> [3] "139593670"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "1.3"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[83]]
#> $Table$Row[[83]]$Cell
#> [1] "1527521"
#> [2] "440163841"
#> [3] "139447649"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "5.1"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[84]]
#> $Table$Row[[84]]$Cell
#> [1] "1527521"
#> [2] "440172005"
#> [3] "139447554"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.7"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[85]]
#> $Table$Row[[85]]$Cell
#> [1] "1527521"
#> [2] "440176009"
#> [3] "139600318"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.19"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[86]]
#> $Table$Row[[86]]$Cell
#> [1] "1527521"
#> [2] "440182946"
#> [3] "155444794"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "2.3"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[87]]
#> $Table$Row[[87]]$Cell
#> [1] "1527521"
#> [2] "440203081"
#> [3] "155444797"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "1.1"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[88]]
#> $Table$Row[[88]]$Cell
#> [1] "1527521"
#> [2] "440207922"
#> [3] "155444848"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "0.27"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[89]]
#> $Table$Row[[89]]$Cell
#> [1] "1527521"
#> [2] "440227038"
#> [3] "139593668"
#> [4] "Inconclusive"
#> [5] "Q01279"
#> [6] ""
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#> [11] ""
#>
#>
#> $Table$Row[[90]]
#> $Table$Row[[90]]$Cell
#> [1] "1740135"
#> [2] "312367127"
#> [3] "71496458"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "2.6"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[91]]
#> $Table$Row[[91]]$Cell
#> [1] "1740135"
#> [2] "461515468"
#> [3] "162643657"
#> [4] "Inconclusive"
#> [5] "Q01279"
#> [6] ""
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[92]]
#> $Table$Row[[92]]$Cell
#> [1] "1740135"
#> [2] "461515649"
#> [3] "162643790"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "9.23"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[93]]
#> $Table$Row[[93]]$Cell
#> [1] "1740135"
#> [2] "461542097"
#> [3] "162662364"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "3.91"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[94]]
#> $Table$Row[[94]]$Cell
#> [1] "1740135"
#> [2] "461543217"
#> [3] "162663118"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[95]]
#> $Table$Row[[95]]$Cell
#> [1] "1740135"
#> [2] "461546315"
#> [3] "162665339"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[96]]
#> $Table$Row[[96]]$Cell
#> [1] "1740135"
#> [2] "461547480"
#> [3] "162666122"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "4.27"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[97]]
#> $Table$Row[[97]]$Cell
#> [1] "1740135"
#> [2] "461549927"
#> [3] "162667840"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "3.79"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[98]]
#> $Table$Row[[98]]$Cell
#> [1] "1740135"
#> [2] "461550238"
#> [3] "162668052"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "2.65"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[99]]
#> $Table$Row[[99]]$Cell
#> [1] "1740135"
#> [2] "461550466"
#> [3] "162668204"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[100]]
#> $Table$Row[[100]]$Cell
#> [1] "1740135"
#> [2] "461555362"
#> [3] "162671649"
#> [4] "Inconclusive"
#> [5] "Q01279"
#> [6] ""
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[101]]
#> $Table$Row[[101]]$Cell
#> [1] "1740135"
#> [2] "461557317"
#> [3] "162673094"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "9.23"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[102]]
#> $Table$Row[[102]]$Cell
#> [1] "1740135"
#> [2] "461557891"
#> [3] "162673491"
#> [4] "Active"
#> [5] "Q01279"
#> [6] "3.79"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[103]]
#> $Table$Row[[103]]$Cell
#> [1] "1740135"
#> [2] "461558880"
#> [3] "162674154"
#> [4] "Inconclusive"
#> [5] "Q01279"
#> [6] ""
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[104]]
#> $Table$Row[[104]]$Cell
#> [1] "1740135"
#> [2] "461562991"
#> [3] "162677073"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#> [11] ""
#>
#>
#> $Table$Row[[105]]
#> $Table$Row[[105]]$Cell
#> [1] "1815786"
#> [2] "475982343"
#> [3] "166627448"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR 19Del/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#> [9] "Other"
#> [10] "35178175"
#> [11] ""
#>
#>
#> $Table$Row[[106]]
#> $Table$Row[[106]]$Cell
#> [1] "1815820"
#> [2] "475982343"
#> [3] "166627448"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR L858R/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#> [9] "Other"
#> [10] "35178175"
#> [11] ""
#>
#>
#> $Table$Row[[107]]
#> $Table$Row[[107]]$Cell
#> [1] "1862914"
#> [2] "482063640"
#> [3] "155431347"
#> [4] "Active"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Invivo inhibition of EGFR phosphorylation in nude mouse implanted with mouse BaF3 cells harboring EGFR del18/T790M/C797S triple mutant at 20 mg/kg, po administered as single dose and measured upto 24 hrs by Western blot analysis"
#> [9] "Other"
#> [10] "35810715"
#> [11] ""
#>
#>
#> $Table$Row[[108]]
#> $Table$Row[[108]]$Cell
#> [1] "1896806"
#> [2] "482061797"
#> [3] "166176964"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#> [9] "Other"
#> [10] "36384036"
#> [11] ""
#>
#>
#> $Table$Row[[109]]
#> $Table$Row[[109]]$Cell
#> [1] "1896806"
#> [2] "482062269"
#> [3] "168280117"
#> [4] "Unspecified"
#> [5] "Q01279"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#> [9] "Other"
#> [10] "36384036"
#> [11] ""result <- get_pug_rest(identifier = "13649", namespace = "geneid", domain = "gene", operation = "pwaccs", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Gene
#> - Namespace: DomainSpecific
#> - Operation: pwaccs
#> - Identifier: 13649
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 PANTHER:P06664
#> 2 PathBank:SMP0120900
#> 3 PathBank:SMP0120901
#> 4 Reactome:R-MMU-1227986
#> 5 Reactome:R-MMU-1236394
#> 6 Reactome:R-MMU-1266738
#> 7 Reactome:R-MMU-157118
#> 8 Reactome:R-MMU-162582
#> 9 Reactome:R-MMU-177929
#> 10 Reactome:R-MMU-179812
#> 11 Reactome:R-MMU-180292
#> 12 Reactome:R-MMU-180336
#> 13 Reactome:R-MMU-182971
#> 14 Reactome:R-MMU-199991
#> 15 Reactome:R-MMU-212718
#> 16 Reactome:R-MMU-2179392
#> 17 Reactome:R-MMU-372790
#> 18 Reactome:R-MMU-373760
#> 19 Reactome:R-MMU-388396
#> 20 Reactome:R-MMU-416476
#> 21 Reactome:R-MMU-422475
#> 22 Reactome:R-MMU-445144
#> 23 Reactome:R-MMU-5653656
#> 24 Reactome:R-MMU-881907
#> 25 Reactome:R-MMU-8848021
#> 26 Reactome:R-MMU-8856825
#> 27 Reactome:R-MMU-8856828
#> 28 Reactome:R-MMU-8857538
#> 29 Reactome:R-MMU-8939211
#> 30 Reactome:R-MMU-9006927
#> 31 Reactome:R-MMU-9006931
#> 32 Reactome:R-MMU-9006934
#> 33 Reactome:R-MMU-9009391
#> 34 Reactome:R-MMU-9012852
#> 35 Reactome:R-MMU-9013507
#> 36 Reactome:R-MMU-9675108
#> 37 WikiPathways:WP1261
#> 38 WikiPathways:WP265
#> 39 WikiPathways:WP2841
#> 40 WikiPathways:WP339
#> 41 WikiPathways:WP3663
#> 42 WikiPathways:WP488
#> 43 WikiPathways:WP493
#> 44 WikiPathways:WP523
#> 45 WikiPathways:WP5242
#> 46 WikiPathways:WP572
#> 47 WikiPathways:WP85These methods offer a comprehensive way to access and analyze gene-related data in PubChem, catering to various research needs in genetics and molecular biology.
PubChem provides a versatile platform for accessing detailed protein data, essential for researchers in biochemistry and molecular biology. Here’s how you can utilize PUG REST for protein-related queries:
1. Protein Input Methods:
result <- get_pug_rest(identifier = "P00533,P01422", namespace = "accession", domain = "protein", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Protein
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: P00533,P01422
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $ProteinSummaries
#> $ProteinSummaries$ProteinSummary
#> $ProteinSummaries$ProteinSummary[[1]]
#> $ProteinSummaries$ProteinSummary[[1]]$ProteinAccession
#> [1] "P00533"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Name
#> [1] "Epidermal growth factor receptor"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Synonym
#> [1] "EC 2.7.10.1"
#> [2] "Proto-oncogene c-ErbB-1"
#> [3] "Receptor tyrosine-protein kinase erbB-1"
#>
#>
#> $ProteinSummaries$ProteinSummary[[2]]
#> $ProteinSummaries$ProteinSummary[[2]]$ProteinAccession
#> [1] "P01422"
#>
#> $ProteinSummaries$ProteinSummary[[2]]$Name
#> [1] "Short neurotoxin 2"
#>
#> $ProteinSummaries$ProteinSummary[[2]]$TaxonomyID
#> [1] 96794
#>
#> $ProteinSummaries$ProteinSummary[[2]]$Taxonomy
#> [1] "Naja annulifera (banded Egyptian cobra)"
#>
#> $ProteinSummaries$ProteinSummary[[2]]$Synonym
#> [1] "Toxin CM-14" "Toxin V-N-I2"By Protein Synonym: Access protein data using synonyms or identifiers from external sources. For example, using a ChEMBL ID:
result <- get_pug_rest(identifier = "ChEMBL:CHEMBL203", namespace = "synonym", domain = "protein", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Protein
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: ChEMBL:CHEMBL203
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $ProteinSummaries
#> $ProteinSummaries$ProteinSummary
#> $ProteinSummaries$ProteinSummary[[1]]
#> $ProteinSummaries$ProteinSummary[[1]]$ProteinAccession
#> [1] "P00533"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Name
#> [1] "Epidermal growth factor receptor"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Synonym
#> [1] "EC 2.7.10.1"
#> [2] "Proto-oncogene c-ErbB-1"
#> [3] "Receptor tyrosine-protein kinase erbB-1"2. Available Protein Data:
result <- get_pug_rest(identifier = "P00533,P01422", namespace = "accession", domain = "protein", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Protein
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: P00533,P01422
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $ProteinSummaries
#> $ProteinSummaries$ProteinSummary
#> $ProteinSummaries$ProteinSummary[[1]]
#> $ProteinSummaries$ProteinSummary[[1]]$ProteinAccession
#> [1] "P00533"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Name
#> [1] "Epidermal growth factor receptor"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#> $ProteinSummaries$ProteinSummary[[1]]$Synonym
#> [1] "EC 2.7.10.1"
#> [2] "Proto-oncogene c-ErbB-1"
#> [3] "Receptor tyrosine-protein kinase erbB-1"
#>
#>
#> $ProteinSummaries$ProteinSummary[[2]]
#> $ProteinSummaries$ProteinSummary[[2]]$ProteinAccession
#> [1] "P01422"
#>
#> $ProteinSummaries$ProteinSummary[[2]]$Name
#> [1] "Short neurotoxin 2"
#>
#> $ProteinSummaries$ProteinSummary[[2]]$TaxonomyID
#> [1] 96794
#>
#> $ProteinSummaries$ProteinSummary[[2]]$Taxonomy
#> [1] "Naja annulifera (banded Egyptian cobra)"
#>
#> $ProteinSummaries$ProteinSummary[[2]]$Synonym
#> [1] "Toxin CM-14" "Toxin V-N-I2"Assays from Protein: Retrieves a list of AIDs tested against a specific protein. For example, for protein accession P00533:
result <- get_pug_rest(identifier = "P00533", namespace = "accession", domain = "protein", operation = "aids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Protein
#> - Namespace: DomainSpecific
#> - Operation: aids
#> - Identifier: P00533
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 1433
#> 2 1726
#> 3 1727
#> 4 1729
#> 5 1731
#> 6 1742
#> 7 1982
#> 8 3364
#> 9 3365
#> 10 7884
#> 11 7888
#> 12 7890
#> 13 7899
#> 14 7901
#> 15 7903
#> 16 7907
#> 17 7909
#> 18 7910
#> 19 7911
#> 20 8066
#> 21 8069
#> 22 8070
#> 23 8076
#> 24 8077
#> 25 8621
#> 26 32370
#> 27 51584
#> 28 66431
#> 29 66435
#> 30 66436
#> 31 66437
#> 32 66442
#> 33 66443
#> 34 66444
#> 35 66445
#> 36 66446
#> 37 66447
#> 38 66448
#> 39 66449
#> 40 66450
#> 41 66451
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#> 43 66453
#> 44 66454
#> 45 66455
#> 46 66456
#> 47 66457
#> 48 66458
#> 49 66459
#> 50 66460
#> 51 66595
#> 52 66596
#> 53 66597
#> 54 66598
#> 55 66599
#> 56 66600
#> 57 66601
#> 58 66602
#> 59 66603
#> 60 66604
#> 61 66605
#> 62 66606
#> 63 66607
#> 64 66608
#> 65 66609
#> 66 66610
#> 67 66611
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#> 71 66615
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#> 81 66627
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#> 83 66629
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#> 85 66631
#> 86 67273
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#> 93 67280
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#> 100 67287
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#> 114 67951
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#> 129 68089
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#> 131 68091
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#> 134 68094
#> 135 69398
#> 136 69399
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#> 201 69577
#> 202 69578
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#> 205 69581
#> 206 69707
#> 207 69708
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#> 225 69874
#> 226 69875
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#> 229 69878
#> 230 69879
#> 231 69880
#> 232 69881
#> 233 69882
#> 234 69883
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#> 237 69886
#> 238 69887
#> 239 69889
#> 240 69890
#> 241 69891
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#> 243 69893
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#> 245 69895
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#> 247 69897
#> 248 69898
#> 249 69899
#> 250 69900
#> 251 69901
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#> 262 70039
#> 263 70041
#> 264 70042
#> 265 70043
#> 266 70044
#> 267 70045
#> 268 70046
#> 269 70047
#> 270 70048
#> 271 70049
#> 272 70050
#> 273 70051
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#> 275 70053
#> 276 70054
#> 277 70055
#> 278 79545
#> 279 81334
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#> 297 84823
#> 298 85137
#> 299 85139
#> 300 89322
#> 301 89323
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#> 304 89326
#> 305 92132
#> 306 96371
#> 307 102177
#> 308 102607
#> 309 162571
#> 310 164333
#> 311 205012
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#> 313 215071
#> 314 219670
#> 315 224428
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#> 340 241976
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#> 342 242149
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#> 344 242228
#> 345 242288
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#> 360 243906
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#> 363 244014
#> 364 244180
#> 365 244206
#> 366 248902
#> 367 248903
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#> 398 260050
#> 399 260441
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#> 415 263980
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#> 421 267201
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#> 423 268483
#> 424 268874
#> 425 269261
#> 426 269262
#> 427 269263
#> 428 269264
#> 429 269265
#> 430 269266
#> 431 269877
#> 432 270617
#> 433 271124
#> 434 271125
#> 435 271202
#> 436 271215
#> 437 271216
#> 438 271751
#> 439 271838
#> 440 271971
#> 441 272233
#> 442 272763
#> 443 273802
#> 444 273821
#> 445 273833
#> 446 275023
#> 447 276188
#> 448 276632
#> 449 276914
#> 450 277404
#> 451 277646
#> 452 281187
#> 453 282236
#> 454 282724
#> 455 283008
#> 456 283009
#> 457 283012
#> 458 283014
#> 459 284566
#> 460 288400
#> 461 288404
#> 462 290551
#> 463 290556
#> 464 295196
#> 465 295762
#> 466 295763
#> 467 295764
#> 468 295765
#> 469 295766
#> 470 295767
#> 471 295768
#> 472 296209
#> 473 296210
#> 474 296994
#> 475 297603
#> 476 297878
#> 477 298426
#> 478 298749
#> 479 299190
#> 480 299322
#> 481 300845
#> 482 301974
#> 483 302721
#> 484 303316
#> 485 305833
#> 486 306290
#> 487 306363
#> 488 306443
#> 489 306907
#> 490 307035
#> 491 307490
#> 492 308302
#> 493 308829
#> 494 309618
#> 495 309619
#> 496 309841
#> 497 309858
#> 498 310063
#> 499 310409
#> 500 313402
#> 501 314511
#> 502 314863
#> 503 314925
#> 504 314966
#> 505 314967
#> 506 315251
#> 507 315727
#> 508 319731
#> 509 320573
#> 510 320620
#> 511 320960
#> 512 323098
#> 513 323517
#> 514 325539
#> 515 325546
#> 516 325547
#> 517 325548
#> 518 325628
#> 519 325790
#> 520 325823
#> 521 325825
#> 522 325842
#> 523 325848
#> 524 327908
#> 525 328042
#> 526 329119
#> 527 329535
#> 528 330087
#> 529 330088
#> 530 330089
#> 531 330090
#> 532 330091
#> 533 331422
#> 534 331435
#> 535 331536
#> 536 331927
#> 537 331999
#> 538 334681
#> 539 337239
#> 540 340324
#> 541 340386
#> 542 341701
#> 543 341711
#> 544 344460
#> 545 345860
#> 546 345874
#> 547 345875
#> 548 345876
#> 549 345877
#> 550 346705
#> 551 347285
#> 552 347662
#> 553 349059
#> 554 349117
#> 555 349132
#> 556 349255
#> 557 350262
#> 558 350326
#> 559 350407
#> 560 350455
#> 561 353508
#> 562 353535
#> 563 353712
#> 564 357183
#> 565 358171
#> 566 358179
#> 567 358180
#> 568 358181
#> 569 358418
#> 570 361267
#> 571 361655
#> 572 362388
#> 573 362392
#> 574 363172
#> 575 364116
#> 576 364141
#> 577 364387
#> 578 364693
#> 579 364801
#> 580 364802
#> 581 365239
#> 582 365899
#> 583 367150
#> 584 367173
#> 585 370515
#> 586 370574
#> 587 370953
#> 588 371020
#> 589 371170
#> 590 371183
#> 591 371298
#> 592 371614
#> 593 372680
#> 594 372681
#> 595 375748
#> 596 378668
#> 597 380371
#> 598 381492
#> 599 381969
#> 600 383062
#> 601 383069
#> 602 383070
#> 603 383071
#> 604 388111
#> 605 388112
#> 606 388113
#> 607 388114
#> 608 388115
#> 609 388814
#> 610 390051
#> 611 390490
#> 612 390491
#> 613 390492
#> 614 390493
#> 615 390494
#> 616 390703
#> 617 390958
#> 618 392129
#> 619 392551
#> 620 392584
#> 621 393229
#> 622 394049
#> 623 394660
#> 624 394661
#> 625 394664
#> 626 394727
#> 627 397043
#> 628 402132
#> 629 405904
#> 630 406968
#> 631 407799
#> 632 408110
#> 633 408788
#> 634 409436
#> 635 410049
#> 636 410895
#> 637 410943
#> 638 410948
#> 639 410951
#> 640 410953
#> 641 412429
#> 642 412433
#> 643 412823
#> 644 414809
#> 645 415003
#> 646 415072
#> 647 417631
#> 648 417896
#> 649 418367
#> 650 418565
#> 651 418566
#> 652 418569
#> 653 418577
#> 654 418918
#> 655 418921
#> 656 419708
#> 657 419709
#> 658 419710
#> 659 419711
#> 660 419712
#> 661 419713
#> 662 419714
#> 663 420172
#> 664 420261
#> 665 420262
#> 666 422340
#> 667 423602
#> 668 427475
#> 669 429308
#> 670 430649
#> 671 433339
#> 672 433340
#> 673 433341
#> 674 433876
#> 675 435137
#> 676 435156
#> 677 435157
#> 678 435392
#> 679 435402
#> 680 435525
#> 681 435652
#> 682 435653
#> 683 435791
#> 684 435792
#> 685 435906
#> 686 435907
#> 687 437896
#> 688 438181
#> 689 439133
#> 690 439275
#> 691 439276
#> 692 439277
#> 693 439278
#> 694 439279
#> 695 439280
#> 696 439281
#> 697 439282
#> 698 439283
#> 699 439284
#> 700 439896
#> 701 440202
#> 702 440203
#> 703 440204
#> 704 440205
#> 705 440617
#> 706 440975
#> 707 441963
#> 708 441965
#> 709 441995
#> 710 444211
#> 711 444990
#> 712 445188
#> 713 445580
#> 714 447768
#> 715 449028
#> 716 450352
#> 717 450353
#> 718 450354
#> 719 450355
#> 720 450598
#> 721 450599
#> 722 450600
#> 723 450601
#> 724 450750
#> 725 450751
#> 726 450752
#> 727 450753
#> 728 451384
#> 729 451414
#> 730 451415
#> 731 451504
#> 732 451505
#> 733 451594
#> 734 451595
#> 735 452116
#> 736 452303
#> 737 453329
#> 738 454326
#> 739 454333
#> 740 455875
#> 741 456090
#> 742 456099
#> 743 456588
#> 744 456589
#> 745 456590
#> 746 456591
#> 747 456592
#> 748 456904
#> 749 457018
#> 750 457029
#> 751 457030
#> 752 457031
#> 753 457032
#> 754 457033
#> 755 457036
#> 756 457038
#> 757 457040
#> 758 457041
#> 759 457278
#> 760 457343
#> 761 458721
#> 762 459558
#> 763 460303
#> 764 460504
#> 765 460689
#> 766 460883
#> 767 460885
#> 768 460933
#> 769 461251
#> 770 463369
#> 771 463638
#> 772 463708
#> 773 463916
#> 774 464481
#> 775 465678
#> 776 466546
#> 777 467361
#> 778 467362
#> 779 467363
#> 780 467364
#> 781 467942
#> 782 469069
#> 783 469664
#> 784 469665
#> 785 469666
#> 786 469667
#> 787 469668
#> 788 470469
#> 789 470891
#> 790 472050
#> 791 472051
#> 792 472897
#> 793 473321
#> 794 473322
#> 795 473323
#> 796 473526
#> 797 474116
#> 798 474118
#> 799 476556
#> 800 480262
#> 801 480551
#> 802 480656
#> 803 481530
#> 804 481817
#> 805 481821
#> 806 481941
#> 807 481945
#> 808 481946
#> 809 481947
#> 810 483380
#> 811 484456
#> 812 484564
#> 813 485509
#> 814 485510
#> 815 485511
#> 816 485512
#> 817 485513
#> 818 485514
#> 819 485515
#> 820 485599
#> 821 485600
#> 822 485601
#> 823 485602
#> 824 486356
#> 825 486357
#> 826 486802
#> 827 488715
#> 828 489258
#> 829 489609
#> 830 490682
#> 831 490683
#> 832 490684
#> 833 490685
#> 834 490686
#> 835 490687
#> 836 490688
#> 837 490689
#> 838 490690
#> 839 490691
#> 840 490692
#> 841 490693
#> 842 491742
#> 843 491922
#> 844 491923
#> 845 492036
#> 846 492108
#> 847 492109
#> 848 492110
#> 849 492320
#> 850 494394
#> 851 494402
#> 852 500003
#> 853 500004
#> 854 502965
#> 855 502966
#> 856 502967
#> 857 502968
#> 858 502969
#> 859 502970
#> 860 503767
#> 861 507084
#> 862 507197
#> 863 507519
#> 864 507520
#> 865 507521
#> 866 507689
#> 867 507690
#> 868 507703
#> 869 507908
#> 870 507910
#> 871 507911
#> 872 507915
#> 873 507916
#> 874 507917
#> 875 509590
#> 876 509715
#> 877 510254
#> 878 510404
#> 879 511488
#> 880 511826
#> 881 512415
#> 882 512421
#> 883 512580
#> 884 513127
#> 885 513986
#> 886 514033
#> 887 514034
#> 888 514035
#> 889 515896
#> 890 516619
#> 891 517218
#> 892 517320
#> 893 517323
#> 894 517562
#> 895 526050
#> 896 527003
#> 897 527448
#> 898 528338
#> 899 528340
#> 900 528341
#> 901 528342
#> 902 535995
#> 903 537796
#> 904 538788
#> 905 539563
#> 906 546551
#> 907 546565
#> 908 549931
#> 909 550444
#> 910 550460
#> 911 550540
#> 912 550541
#> 913 550624
#> 914 550663
#> 915 552199
#> 916 552200
#> 917 552201
#> 918 552202
#> 919 552203
#> 920 553029
#> 921 577967
#> 922 577995
#> 923 578471
#> 924 578699
#> 925 578726
#> 926 579003
#> 927 579111
#> 928 580190
#> 929 581172
#> 930 586443
#> 931 589576
#> 932 589577
#> 933 589684
#> 934 591162
#> 935 591887
#> 936 592282
#> 937 592965
#> 938 596576
#> 939 597038
#> 940 597116
#> 941 597681
#> 942 598164
#> 943 598165
#> 944 598839
#> 945 599704
#> 946 601667
#> 947 601668
#> 948 601669
#> 949 601670
#> 950 602888
#> 951 603083
#> 952 603816
#> 953 603958
#> 954 605587
#> 955 605826
#> 956 607978
#> 957 608487
#> 958 609409
#> 959 611835
#> 960 611842
#> 961 611845
#> 962 612122
#> 963 612771
#> 964 613153
#> 965 613199
#> 966 613200
#> 967 613201
#> 968 613202
#> 969 613203
#> 970 613204
#> 971 613205
#> 972 614856
#> 973 615007
#> 974 615098
#> 975 615120
#> 976 615354
#> 977 615355
#> 978 616546
#> 979 616951
#> 980 618743
#> 981 618971
#> 982 620239
#> 983 620241
#> 984 621665
#> 985 623492
#> 986 624996
#> 987 624997
#> 988 624998
#> 989 624999
#> 990 625000
#> 991 625001
#> 992 625002
#> 993 625003
#> 994 625004
#> 995 625005
#> 996 625006
#> 997 625007
#> 998 625184
#> 999 625519
#> 1000 626081
#> 1001 627245
#> 1002 627246
#> 1003 627247
#> 1004 629219
#> 1005 629272
#> 1006 629306
#> 1007 629471
#> 1008 629472
#> 1009 629473
#> 1010 629824
#> 1011 629825
#> 1012 629826
#> 1013 629929
#> 1014 630068
#> 1015 630334
#> 1016 630515
#> 1017 630516
#> 1018 630766
#> 1019 630785
#> 1020 632227
#> 1021 633717
#> 1022 634135
#> 1023 634136
#> 1024 634625
#> 1025 634930
#> 1026 636123
#> 1027 636131
#> 1028 636163
#> 1029 636384
#> 1030 636420
#> 1031 637121
#> 1032 637257
#> 1033 637323
#> 1034 637639
#> 1035 638067
#> 1036 638084
#> 1037 638112
#> 1038 638916
#> 1039 639687
#> 1040 640254
#> 1041 641996
#> 1042 642302
#> 1043 642483
#> 1044 642760
#> 1045 642761
#> 1046 643601
#> 1047 643942
#> 1048 644271
#> 1049 644272
#> 1050 644745
#> 1051 644746
#> 1052 645933
#> 1053 646071
#> 1054 646402
#> 1055 647744
#> 1056 647745
#> 1057 648951
#> 1058 649305
#> 1059 649352
#> 1060 649840
#> 1061 650379
#> 1062 650455
#> 1063 650467
#> 1064 650681
#> 1065 651402
#> 1066 651403
#> 1067 651404
#> 1068 651405
#> 1069 651406
#> 1070 651407
#> 1071 651408
#> 1072 651409
#> 1073 651410
#> 1074 651411
#> 1075 653733
#> 1076 653881
#> 1077 654153
#> 1078 654154
#> 1079 655326
#> 1080 655327
#> 1081 655328
#> 1082 655329
#> 1083 655330
#> 1084 655996
#> 1085 656205
#> 1086 656465
#> 1087 656489
#> 1088 660688
#> 1089 660894
#> 1090 661561
#> 1091 661562
#> 1092 661563
#> 1093 661564
#> 1094 661582
#> 1095 661583
#> 1096 661590
#> 1097 661591
#> 1098 661592
#> 1099 662478
#> 1100 662479
#> 1101 662480
#> 1102 662481
#> 1103 662482
#> 1104 662483
#> 1105 662484
#> 1106 662485
#> 1107 662486
#> 1108 662487
#> 1109 662508
#> 1110 662509
#> 1111 662510
#> 1112 662511
#> 1113 662512
#> 1114 662577
#> 1115 662578
#> 1116 662579
#> 1117 662580
#> 1118 662581
#> 1119 662582
#> 1120 662583
#> 1121 662584
#> 1122 662585
#> 1123 662586
#> 1124 662587
#> 1125 662588
#> 1126 662589
#> 1127 662590
#> 1128 662591
#> 1129 662592
#> 1130 662593
#> 1131 662594
#> 1132 662595
#> 1133 662616
#> 1134 662617
#> 1135 662802
#> 1136 662803
#> 1137 662804
#> 1138 664631
#> 1139 664632
#> 1140 664736
#> 1141 664738
#> 1142 666196
#> 1143 666197
#> 1144 666198
#> 1145 666199
#> 1146 666200
#> 1147 666201
#> 1148 666202
#> 1149 666203
#> 1150 666324
#> 1151 669884
#> 1152 670127
#> 1153 670129
#> 1154 670513
#> 1155 671088
#> 1156 673705
#> 1157 674129
#> 1158 674429
#> 1159 674615
#> 1160 674645
#> 1161 674789
#> 1162 674790
#> 1163 677070
#> 1164 677662
#> 1165 678104
#> 1166 678508
#> 1167 678509
#> 1168 678514
#> 1169 683479
#> 1170 683480
#> 1171 684216
#> 1172 684962
#> 1173 685282
#> 1174 685434
#> 1175 688739
#> 1176 688861
#> 1177 688862
#> 1178 688863
#> 1179 688864
#> 1180 688865
#> 1181 688866
#> 1182 688867
#> 1183 688868
#> 1184 688869
#> 1185 688870
#> 1186 688871
#> 1187 688872
#> 1188 688873
#> 1189 688874
#> 1190 688875
#> 1191 688876
#> 1192 688881
#> 1193 689246
#> 1194 689488
#> 1195 689489
#> 1196 689490
#> 1197 689491
#> 1198 689664
#> 1199 689668
#> 1200 689678
#> 1201 690171
#> 1202 690206
#> 1203 691095
#> 1204 692840
#> 1205 694020
#> 1206 695967
#> 1207 696622
#> 1208 697296
#> 1209 697382
#> 1210 701047
#> 1211 705003
#> 1212 708790
#> 1213 708791
#> 1214 708792
#> 1215 708793
#> 1216 708794
#> 1217 708795
#> 1218 708796
#> 1219 708839
#> 1220 708842
#> 1221 708972
#> 1222 708973
#> 1223 708974
#> 1224 708975
#> 1225 708978
#> 1226 708983
#> 1227 708984
#> 1228 709746
#> 1229 710535
#> 1230 710623
#> 1231 711534
#> 1232 711547
#> 1233 713443
#> 1234 714343
#> 1235 714344
#> 1236 714345
#> 1237 714346
#> 1238 714347
#> 1239 714348
#> 1240 714349
#> 1241 714545
#> 1242 714546
#> 1243 714547
#> 1244 714548
#> 1245 714549
#> 1246 715336
#> 1247 718823
#> 1248 719077
#> 1249 719231
#> 1250 719884
#> 1251 719885
#> 1252 719886
#> 1253 719889
#> 1254 719892
#> 1255 720121
#> 1256 720122
#> 1257 720910
#> 1258 721391
#> 1259 722207
#> 1260 723353
#> 1261 725957
#> 1262 725958
#> 1263 725963
#> 1264 725966
#> 1265 727732
#> 1266 727733
#> 1267 727734
#> 1268 729554
#> 1269 729555
#> 1270 729556
#> 1271 729557
#> 1272 729977
#> 1273 730005
#> 1274 731106
#> 1275 731916
#> 1276 732198
#> 1277 734141
#> 1278 734221
#> 1279 734224
#> 1280 734773
#> 1281 735315
#> 1282 735372
#> 1283 737513
#> 1284 737514
#> 1285 737515
#> 1286 737516
#> 1287 737517
#> 1288 738834
#> 1289 738835
#> 1290 738836
#> 1291 738837
#> 1292 739385
#> 1293 739427
#> 1294 739428
#> 1295 739429
#> 1296 739430
#> 1297 739685
#> 1298 739688
#> 1299 739690
#> 1300 739692
#> 1301 739693
#> 1302 739789
#> 1303 740396
#> 1304 740397
#> 1305 740935
#> 1306 740936
#> 1307 741245
#> 1308 741246
#> 1309 741247
#> 1310 741248
#> 1311 741249
#> 1312 743668
#> 1313 743671
#> 1314 745320
#> 1315 745352
#> 1316 746532
#> 1317 748064
#> 1318 748065
#> 1319 748066
#> 1320 748067
#> 1321 748068
#> 1322 748069
#> 1323 748091
#> 1324 748093
#> 1325 748094
#> 1326 748799
#> 1327 748805
#> 1328 749335
#> 1329 749394
#> 1330 749763
#> 1331 750072
#> 1332 752152
#> 1333 752176
#> 1334 752702
#> 1335 753284
#> 1336 755962
#> 1337 757290
#> 1338 757291
#> 1339 757292
#> 1340 757293
#> 1341 757294
#> 1342 757674
#> 1343 758024
#> 1344 760331
#> 1345 760332
#> 1346 761265
#> 1347 761587
#> 1348 761588
#> 1349 761589
#> 1350 761591
#> 1351 761601
#> 1352 761602
#> 1353 761603
#> 1354 764900
#> 1355 764901
#> 1356 764902
#> 1357 764903
#> 1358 764904
#> 1359 764905
#> 1360 764906
#> 1361 764907
#> 1362 764908
#> 1363 764909
#> 1364 764910
#> 1365 764911
#> 1366 764912
#> 1367 764925
#> 1368 764926
#> 1369 764927
#> 1370 764928
#> 1371 766544
#> 1372 766550
#> 1373 766931
#> 1374 767006
#> 1375 767092
#> 1376 768502
#> 1377 769201
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#> 1379 769206
#> 1380 769207
#> 1381 769368
#> 1382 770078
#> 1383 770081
#> 1384 770082
#> 1385 770083
#> 1386 770096
#> 1387 770439
#> 1388 770794
#> 1389 771338
#> 1390 771341
#> 1391 771342
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#> 1406 776746
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#> 1418 779874
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#> 1420 780820
#> 1421 1053577
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#> 1489 1093388
#> 1490 1106449
#> 1491 1117570
#> 1492 1117574
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#> 1494 1117576
#> 1495 1117578
#> 1496 1117804
#> 1497 1117806
#> 1498 1119051
#> 1499 1119724
#> 1500 1119822
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#> 1503 1119828
#> 1504 1119829
#> 1505 1119830
#> 1506 1119835
#> 1507 1119836
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#> 1509 1119838
#> 1510 1119839
#> 1511 1119840
#> 1512 1119841
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#> 1514 1119844
#> 1515 1119845
#> 1516 1119846
#> 1517 1120079
#> 1518 1120256
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#> 1520 1120258
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#> 1523 1120261
#> 1524 1120262
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#> 1560 1137607
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#> 1564 1140573
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#> 1568 1142994
#> 1569 1155021
#> 1570 1155097
#> 1571 1155100
#> 1572 1155502
#> 1573 1155508
#> 1574 1156999
#> 1575 1157406
#> 1576 1157567
#> 1577 1158369
#> 1578 1160535
#> 1579 1160536
#> 1580 1162094
#> 1581 1163157
#> 1582 1163158
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#> 1584 1163160
#> 1585 1163161
#> 1586 1163162
#> 1587 1163163
#> 1588 1163187
#> 1589 1163188
#> 1590 1163220
#> 1591 1163221
#> 1592 1163222
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#> 1594 1163224
#> 1595 1163225
#> 1596 1163289
#> 1597 1163503
#> 1598 1164107
#> 1599 1165336
#> 1600 1167082
#> 1601 1167101
#> 1602 1167102
#> 1603 1167103
#> 1604 1167665
#> 1605 1167806
#> 1606 1168535
#> 1607 1168539
#> 1608 1168541
#> 1609 1168542
#> 1610 1168545
#> 1611 1168547
#> 1612 1168548
#> 1613 1168554
#> 1614 1169271
#> 1615 1170394
#> 1616 1170824
#> 1617 1170825
#> 1618 1170826
#> 1619 1170838
#> 1620 1170839
#> 1621 1170850
#> 1622 1170851
#> 1623 1171419
#> 1624 1171420
#> 1625 1172278
#> 1626 1172507
#> 1627 1173104
#> 1628 1173170
#> 1629 1173888
#> 1630 1173894
#> 1631 1173900
#> 1632 1174299
#> 1633 1174871
#> 1634 1175324
#> 1635 1175520
#> 1636 1176840
#> 1637 1177759
#> 1638 1178238
#> 1639 1178239
#> 1640 1178687
#> 1641 1179013
#> 1642 1179600
#> 1643 1181816
#> 1644 1182667
#> 1645 1182830
#> 1646 1184140
#> 1647 1184492
#> 1648 1186391
#> 1649 1186630
#> 1650 1187672
#> 1651 1189770
#> 1652 1189786
#> 1653 1190102
#> 1654 1190117
#> 1655 1190132
#> 1656 1190997
#> 1657 1191001
#> 1658 1191167
#> 1659 1192060
#> 1660 1192061
#> 1661 1192062
#> 1662 1192063
#> 1663 1192065
#> 1664 1193682
#> 1665 1193684
#> 1666 1193956
#> 1667 1195283
#> 1668 1198818
#> 1669 1201366
#> 1670 1201367
#> 1671 1201368
#> 1672 1201369
#> 1673 1201370
#> 1674 1201886
#> 1675 1201887
#> 1676 1202434
#> 1677 1204628
#> 1678 1204629
#> 1679 1204630
#> 1680 1205021
#> 1681 1205971
#> 1682 1206239
#> 1683 1223918
#> 1684 1224256
#> 1685 1226561
#> 1686 1226614
#> 1687 1230130
#> 1688 1234624
#> 1689 1234984
#> 1690 1235505
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#> 1692 1240683
#> 1693 1241286
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#> 1695 1241288
#> 1696 1241289
#> 1697 1241290
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#> 1700 1241297
#> 1701 1241298
#> 1702 1241299
#> 1703 1241300
#> 1704 1242283
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#> 1706 1242285
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#> 1708 1242287
#> 1709 1243173
#> 1710 1243176
#> 1711 1243996
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#> 1713 1244850
#> 1714 1244851
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#> 1719 1244856
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#> 1721 1247624
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#> 1725 1247698
#> 1726 1247699
#> 1727 1247700
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#> 1729 1247702
#> 1730 1247703
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#> 1732 1250263
#> 1733 1250365
#> 1734 1250380
#> 1735 1250405
#> 1736 1250406
#> 1737 1250407
#> 1738 1250408
#> 1739 1250409
#> 1740 1250410
#> 1741 1250411
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#> 1743 1251091
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#> 1745 1251460
#> 1746 1251475
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#> 1748 1252466
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#> 1750 1252717
#> 1751 1253271
#> 1752 1253398
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#> 1755 1254370
#> 1756 1255209
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#> 1758 1255211
#> 1759 1255233
#> 1760 1255234
#> 1761 1255250
#> 1762 1255251
#> 1763 1256452
#> 1764 1261426
#> 1765 1261427
#> 1766 1261447
#> 1767 1261455
#> 1768 1261456
#> 1769 1261461
#> 1770 1262476
#> 1771 1263409
#> 1772 1263411
#> 1773 1263969
#> 1774 1263972
#> 1775 1263984
#> 1776 1263987
#> 1777 1264286
#> 1778 1264287
#> 1779 1264288
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#> 1781 1264290
#> 1782 1264291
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#> 1784 1264572
#> 1785 1264814
#> 1786 1266267
#> 1787 1266268
#> 1788 1266550
#> 1789 1267818
#> 1790 1268284
#> 1791 1268676
#> 1792 1268756
#> 1793 1269775
#> 1794 1269991
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#> 1796 1270377
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#> 1798 1270379
#> 1799 1270380
#> 1800 1270381
#> 1801 1270382
#> 1802 1270384
#> 1803 1270385
#> 1804 1270386
#> 1805 1270387
#> 1806 1270388
#> 1807 1270393
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#> 1809 1270398
#> 1810 1270399
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#> 1812 1270401
#> 1813 1270402
#> 1814 1270403
#> 1815 1270404
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#> 1817 1272593
#> 1818 1273072
#> 1819 1273653
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#> 1821 1273663
#> 1822 1274037
#> 1823 1274046
#> 1824 1274047
#> 1825 1274048
#> 1826 1274049
#> 1827 1274115
#> 1828 1274116
#> 1829 1274117
#> 1830 1274118
#> 1831 1274119
#> 1832 1274360
#> 1833 1274365
#> 1834 1274919
#> 1835 1275676
#> 1836 1276507
#> 1837 1277862
#> 1838 1278231
#> 1839 1278392
#> 1840 1278393
#> 1841 1278394
#> 1842 1278400
#> 1843 1278401
#> 1844 1279048
#> 1845 1279101
#> 1846 1279299
#> 1847 1279301
#> 1848 1280769
#> 1849 1283722
#> 1850 1283723
#> 1851 1283724
#> 1852 1283725
#> 1853 1283726
#> 1854 1283992
#> 1855 1283993
#> 1856 1284867
#> 1857 1284943
#> 1858 1284944
#> 1859 1285190
#> 1860 1285291
#> 1861 1286788
#> 1862 1286789
#> 1863 1286791
#> 1864 1286793
#> 1865 1286794
#> 1866 1287299
#> 1867 1287300
#> 1868 1288051
#> 1869 1289534
#> 1870 1289535
#> 1871 1289536
#> 1872 1289537
#> 1873 1289538
#> 1874 1289541
#> 1875 1289542
#> 1876 1289543
#> 1877 1289544
#> 1878 1289545
#> 1879 1289546
#> 1880 1289550
#> 1881 1289551
#> 1882 1289554
#> 1883 1289555
#> 1884 1289557
#> 1885 1289558
#> 1886 1289559
#> 1887 1289561
#> 1888 1290653
#> 1889 1290958
#> 1890 1291005
#> 1891 1291016
#> 1892 1291323
#> 1893 1291324
#> 1894 1291325
#> 1895 1291326
#> 1896 1291327
#> 1897 1291328
#> 1898 1291329
#> 1899 1291330
#> 1900 1291332
#> 1901 1291334
#> 1902 1291335
#> 1903 1291336
#> 1904 1291347
#> 1905 1291348
#> 1906 1291349
#> 1907 1291350
#> 1908 1291351
#> 1909 1291354
#> 1910 1293803
#> 1911 1294530
#> 1912 1295944
#> 1913 1295947
#> 1914 1296983
#> 1915 1297808
#> 1916 1297809
#> 1917 1298012
#> 1918 1298088
#> 1919 1298203
#> 1920 1298204
#> 1921 1298217
#> 1922 1298487
#> 1923 1298660
#> 1924 1298661
#> 1925 1298663
#> 1926 1298664
#> 1927 1298665
#> 1928 1298673
#> 1929 1298674
#> 1930 1298675
#> 1931 1298676
#> 1932 1298677
#> 1933 1300486
#> 1934 1301213
#> 1935 1301217
#> 1936 1301348
#> 1937 1301349
#> 1938 1301350
#> 1939 1301362
#> 1940 1301717
#> 1941 1301793
#> 1942 1301821
#> 1943 1301832
#> 1944 1303327
#> 1945 1303331
#> 1946 1303332
#> 1947 1303333
#> 1948 1303334
#> 1949 1303336
#> 1950 1303337
#> 1951 1303338
#> 1952 1303339
#> 1953 1303342
#> 1954 1303499
#> 1955 1303500
#> 1956 1305066
#> 1957 1305352
#> 1958 1305355
#> 1959 1305356
#> 1960 1305357
#> 1961 1305360
#> 1962 1305361
#> 1963 1305373
#> 1964 1305808
#> 1965 1306574
#> 1966 1306576
#> 1967 1306577
#> 1968 1306578
#> 1969 1306579
#> 1970 1306580
#> 1971 1306581
#> 1972 1306585
#> 1973 1306586
#> 1974 1306587
#> 1975 1306588
#> 1976 1307364
#> 1977 1307365
#> 1978 1307366
#> 1979 1307368
#> 1980 1307369
#> 1981 1308939
#> 1982 1308940
#> 1983 1308941
#> 1984 1308942
#> 1985 1309512
#> 1986 1309513
#> 1987 1309514
#> 1988 1309518
#> 1989 1309519
#> 1990 1310977
#> 1991 1312467
#> 1992 1312557
#> 1993 1312558
#> 1994 1312564
#> 1995 1312565
#> 1996 1312566
#> 1997 1313622
#> 1998 1315424
#> 1999 1315978
#> 2000 1315982
#> 2001 1315985
#> 2002 1315986
#> 2003 1315987
#> 2004 1317489
#> 2005 1317873
#> 2006 1317881
#> 2007 1317922
#> 2008 1317923
#> 2009 1319175
#> 2010 1321087
#> 2011 1321088
#> 2012 1321089
#> 2013 1321090
#> 2014 1321091
#> 2015 1321092
#> 2016 1321093
#> 2017 1321095
#> 2018 1321096
#> 2019 1321097
#> 2020 1321098
#> 2021 1321151
#> 2022 1321152
#> 2023 1321153
#> 2024 1321154
#> 2025 1321923
#> 2026 1321924
#> 2027 1321926
#> 2028 1325432
#> 2029 1326940
#> 2030 1330640
#> 2031 1330728
#> 2032 1330842
#> 2033 1330923
#> 2034 1330924
#> 2035 1330928
#> 2036 1330931
#> 2037 1330933
#> 2038 1330935
#> 2039 1330937
#> 2040 1330939
#> 2041 1330949
#> 2042 1330950
#> 2043 1330966
#> 2044 1330967
#> 2045 1335027
#> 2046 1335805
#> 2047 1336032
#> 2048 1337176
#> 2049 1337730
#> 2050 1341596
#> 2051 1341617
#> 2052 1341622
#> 2053 1341624
#> 2054 1341757
#> 2055 1341758
#> 2056 1341763
#> 2057 1341764
#> 2058 1341765
#> 2059 1341766
#> 2060 1341767
#> 2061 1342328
#> 2062 1342636
#> 2063 1345502
#> 2064 1348155
#> 2065 1350803
#> 2066 1350804
#> 2067 1350805
#> 2068 1350806
#> 2069 1350814
#> 2070 1350815
#> 2071 1350816
#> 2072 1350817
#> 2073 1350820
#> 2074 1350821
#> 2075 1350822
#> 2076 1350853
#> 2077 1350854
#> 2078 1350855
#> 2079 1350856
#> 2080 1350857
#> 2081 1350858
#> 2082 1350859
#> 2083 1350860
#> 2084 1350861
#> 2085 1350862
#> 2086 1350863
#> 2087 1350864
#> 2088 1350897
#> 2089 1352745
#> 2090 1352750
#> 2091 1353459
#> 2092 1353460
#> 2093 1353461
#> 2094 1353462
#> 2095 1353463
#> 2096 1353464
#> 2097 1353465
#> 2098 1353466
#> 2099 1353467
#> 2100 1353468
#> 2101 1353469
#> 2102 1353470
#> 2103 1353471
#> 2104 1353472
#> 2105 1353476
#> 2106 1353477
#> 2107 1353478
#> 2108 1353479
#> 2109 1353480
#> 2110 1353481
#> 2111 1353482
#> 2112 1357746
#> 2113 1357755
#> 2114 1358748
#> 2115 1358811
#> 2116 1359368
#> 2117 1359369
#> 2118 1359374
#> 2119 1359375
#> 2120 1359376
#> 2121 1359377
#> 2122 1359917
#> 2123 1359922
#> 2124 1359923
#> 2125 1360607
#> 2126 1360965
#> 2127 1361678
#> 2128 1361679
#> 2129 1361680
#> 2130 1361681
#> 2131 1361682
#> 2132 1361683
#> 2133 1361863
#> 2134 1361864
#> 2135 1361865
#> 2136 1361866
#> 2137 1361867
#> 2138 1361868
#> 2139 1361869
#> 2140 1361871
#> 2141 1361872
#> 2142 1361873
#> 2143 1361874
#> 2144 1364047
#> 2145 1364403
#> 2146 1364452
#> 2147 1364453
#> 2148 1364458
#> 2149 1364459
#> 2150 1364462
#> 2151 1364463
#> 2152 1364466
#> 2153 1364537
#> 2154 1364538
#> 2155 1364539
#> 2156 1364541
#> 2157 1364542
#> 2158 1364543
#> 2159 1364545
#> 2160 1364548
#> 2161 1365191
#> 2162 1365564
#> 2163 1365565
#> 2164 1365566
#> 2165 1365567
#> 2166 1365568
#> 2167 1365569
#> 2168 1365570
#> 2169 1365571
#> 2170 1365572
#> 2171 1365573
#> 2172 1365574
#> 2173 1365575
#> 2174 1365576
#> 2175 1365577
#> 2176 1365578
#> 2177 1365583
#> 2178 1365584
#> 2179 1365585
#> 2180 1365586
#> 2181 1365587
#> 2182 1365748
#> 2183 1366001
#> 2184 1367262
#> 2185 1367529
#> 2186 1367530
#> 2187 1368035
#> 2188 1368036
#> 2189 1370352
#> 2190 1370933
#> 2191 1371602
#> 2192 1371603
#> 2193 1371604
#> 2194 1371605
#> 2195 1371606
#> 2196 1371607
#> 2197 1371608
#> 2198 1371609
#> 2199 1371610
#> 2200 1371611
#> 2201 1371612
#> 2202 1371613
#> 2203 1372110
#> 2204 1372112
#> 2205 1372113
#> 2206 1372114
#> 2207 1372115
#> 2208 1372117
#> 2209 1372118
#> 2210 1372400
#> 2211 1373080
#> 2212 1373081
#> 2213 1374818
#> 2214 1375525
#> 2215 1376029
#> 2216 1376035
#> 2217 1376036
#> 2218 1376515
#> 2219 1376516
#> 2220 1376517
#> 2221 1376518
#> 2222 1376519
#> 2223 1378273
#> 2224 1378274
#> 2225 1378275
#> 2226 1378276
#> 2227 1378277
#> 2228 1378278
#> 2229 1378279
#> 2230 1378280
#> 2231 1378281
#> 2232 1378282
#> 2233 1378283
#> 2234 1378287
#> 2235 1378288
#> 2236 1378289
#> 2237 1378290
#> 2238 1378291
#> 2239 1378292
#> 2240 1378293
#> 2241 1379773
#> 2242 1381595
#> 2243 1381744
#> 2244 1381770
#> 2245 1382532
#> 2246 1382533
#> 2247 1382534
#> 2248 1382535
#> 2249 1382536
#> 2250 1382537
#> 2251 1382538
#> 2252 1389856
#> 2253 1389857
#> 2254 1389858
#> 2255 1389969
#> 2256 1389971
#> 2257 1390633
#> 2258 1390635
#> 2259 1390636
#> 2260 1390638
#> 2261 1390894
#> 2262 1391281
#> 2263 1391283
#> 2264 1391284
#> 2265 1391286
#> 2266 1391841
#> 2267 1393181
#> 2268 1393599
#> 2269 1394199
#> 2270 1394200
#> 2271 1394201
#> 2272 1394202
#> 2273 1394203
#> 2274 1394204
#> 2275 1394205
#> 2276 1394206
#> 2277 1394207
#> 2278 1394208
#> 2279 1394209
#> 2280 1394210
#> 2281 1394679
#> 2282 1394683
#> 2283 1394726
#> 2284 1394727
#> 2285 1394812
#> 2286 1395241
#> 2287 1396416
#> 2288 1396417
#> 2289 1396513
#> 2290 1396514
#> 2291 1396811
#> 2292 1396844
#> 2293 1397231
#> 2294 1398876
#> 2295 1399364
#> 2296 1399807
#> 2297 1401884
#> 2298 1401963
#> 2299 1402422
#> 2300 1402423
#> 2301 1402424
#> 2302 1402504
#> 2303 1402505
#> 2304 1402506
#> 2305 1402960
#> 2306 1402961
#> 2307 1402962
#> 2308 1402963
#> 2309 1403293
#> 2310 1403294
#> 2311 1403917
#> 2312 1404100
#> 2313 1404619
#> 2314 1404759
#> 2315 1404897
#> 2316 1404960
#> 2317 1404962
#> 2318 1404963
#> 2319 1404964
#> 2320 1404965
#> 2321 1404966
#> 2322 1404967
#> 2323 1404968
#> 2324 1404974
#> 2325 1404975
#> 2326 1404976
#> 2327 1404977
#> 2328 1404978
#> 2329 1404979
#> 2330 1404980
#> 2331 1404981
#> 2332 1406661
#> 2333 1407099
#> 2334 1407100
#> 2335 1407101
#> 2336 1407105
#> 2337 1407106
#> 2338 1409093
#> 2339 1411545
#> 2340 1411546
#> 2341 1411549
#> 2342 1411550
#> 2343 1411551
#> 2344 1411556
#> 2345 1411557
#> 2346 1411558
#> 2347 1412316
#> 2348 1412317
#> 2349 1412321
#> 2350 1412322
#> 2351 1412323
#> 2352 1412324
#> 2353 1412325
#> 2354 1412326
#> 2355 1412463
#> 2356 1412703
#> 2357 1412708
#> 2358 1412846
#> 2359 1415023
#> 2360 1417363
#> 2361 1417834
#> 2362 1417835
#> 2363 1417836
#> 2364 1417837
#> 2365 1417838
#> 2366 1417839
#> 2367 1417840
#> 2368 1417841
#> 2369 1417842
#> 2370 1417843
#> 2371 1417844
#> 2372 1417845
#> 2373 1418418
#> 2374 1418419
#> 2375 1418420
#> 2376 1419163
#> 2377 1419930
#> 2378 1419931
#> 2379 1420632
#> 2380 1420633
#> 2381 1420634
#> 2382 1420635
#> 2383 1420636
#> 2384 1420640
#> 2385 1420671
#> 2386 1420674
#> 2387 1420676
#> 2388 1420678
#> 2389 1420679
#> 2390 1420680
#> 2391 1420681
#> 2392 1420682
#> 2393 1420683
#> 2394 1420684
#> 2395 1420685
#> 2396 1420686
#> 2397 1421134
#> 2398 1421264
#> 2399 1421409
#> 2400 1421410
#> 2401 1422234
#> 2402 1423307
#> 2403 1423308
#> 2404 1423311
#> 2405 1423312
#> 2406 1423824
#> 2407 1423825
#> 2408 1423826
#> 2409 1423828
#> 2410 1423829
#> 2411 1423830
#> 2412 1423831
#> 2413 1424192
#> 2414 1424193
#> 2415 1424200
#> 2416 1424201
#> 2417 1424202
#> 2418 1424203
#> 2419 1424204
#> 2420 1424205
#> 2421 1424206
#> 2422 1424207
#> 2423 1424261
#> 2424 1424262
#> 2425 1424361
#> 2426 1424363
#> 2427 1424364
#> 2428 1424369
#> 2429 1424371
#> 2430 1424372
#> 2431 1424373
#> 2432 1424398
#> 2433 1424983
#> 2434 1426855
#> 2435 1426964
#> 2436 1428029
#> 2437 1428030
#> 2438 1428362
#> 2439 1428884
#> 2440 1430980
#> 2441 1431174
#> 2442 1431285
#> 2443 1432775
#> 2444 1432776
#> 2445 1432777
#> 2446 1432797
#> 2447 1432798
#> 2448 1432799
#> 2449 1432800
#> 2450 1434201
#> 2451 1434568
#> 2452 1434569
#> 2453 1434579
#> 2454 1434580
#> 2455 1434581
#> 2456 1434582
#> 2457 1435450
#> 2458 1435625
#> 2459 1435626
#> 2460 1435627
#> 2461 1435628
#> 2462 1435629
#> 2463 1435630
#> 2464 1436457
#> 2465 1436879
#> 2466 1438343
#> 2467 1439619
#> 2468 1439620
#> 2469 1439621
#> 2470 1439622
#> 2471 1439623
#> 2472 1439624
#> 2473 1439625
#> 2474 1439629
#> 2475 1439630
#> 2476 1439631
#> 2477 1439632
#> 2478 1439753
#> 2479 1440116
#> 2480 1440316
#> 2481 1440730
#> 2482 1441910
#> 2483 1441911
#> 2484 1441912
#> 2485 1441913
#> 2486 1441914
#> 2487 1441917
#> 2488 1441922
#> 2489 1441923
#> 2490 1441924
#> 2491 1441925
#> 2492 1441929
#> 2493 1441930
#> 2494 1441931
#> 2495 1441932
#> 2496 1441937
#> 2497 1441938
#> 2498 1441939
#> 2499 1441940
#> 2500 1441941
#> 2501 1441942
#> 2502 1441944
#> 2503 1441945
#> 2504 1441946
#> 2505 1441947
#> 2506 1441948
#> 2507 1441949
#> 2508 1441950
#> 2509 1441951
#> 2510 1441952
#> 2511 1442426
#> 2512 1442427
#> 2513 1442428
#> 2514 1443455
#> 2515 1443465
#> 2516 1443477
#> 2517 1443538
#> 2518 1444111
#> 2519 1444155
#> 2520 1444158
#> 2521 1444159
#> 2522 1444160
#> 2523 1444161
#> 2524 1445468
#> 2525 1445469
#> 2526 1445470
#> 2527 1445471
#> 2528 1445472
#> 2529 1445473
#> 2530 1445474
#> 2531 1445479
#> 2532 1445480
#> 2533 1445481
#> 2534 1446437
#> 2535 1446714
#> 2536 1446715
#> 2537 1450098
#> 2538 1450405
#> 2539 1450412
#> 2540 1450709
#> 2541 1450710
#> 2542 1450767
#> 2543 1450768
#> 2544 1450769
#> 2545 1452382
#> 2546 1452454
#> 2547 1455679
#> 2548 1458976
#> 2549 1458977
#> 2550 1458978
#> 2551 1459020
#> 2552 1461120
#> 2553 1461121
#> 2554 1461122
#> 2555 1461123
#> 2556 1461124
#> 2557 1461125
#> 2558 1461126
#> 2559 1461127
#> 2560 1461128
#> 2561 1461129
#> 2562 1461130
#> 2563 1461131
#> 2564 1461711
#> 2565 1461712
#> 2566 1461714
#> 2567 1461715
#> 2568 1461716
#> 2569 1461717
#> 2570 1461718
#> 2571 1461719
#> 2572 1461720
#> 2573 1461721
#> 2574 1461722
#> 2575 1462163
#> 2576 1463353
#> 2577 1463973
#> 2578 1463975
#> 2579 1464302
#> 2580 1464456
#> 2581 1466303
#> 2582 1466304
#> 2583 1466329
#> 2584 1466854
#> 2585 1468807
#> 2586 1469701
#> 2587 1469776
#> 2588 1469777
#> 2589 1469778
#> 2590 1469779
#> 2591 1469890
#> 2592 1470056
#> 2593 1470057
#> 2594 1470058
#> 2595 1470059
#> 2596 1470060
#> 2597 1470061
#> 2598 1470062
#> 2599 1470063
#> 2600 1470064
#> 2601 1470065
#> 2602 1470066
#> 2603 1470067
#> 2604 1470863
#> 2605 1470864
#> 2606 1470865
#> 2607 1470939
#> 2608 1470940
#> 2609 1470960
#> 2610 1471073
#> 2611 1471074
#> 2612 1471075
#> 2613 1471076
#> 2614 1471077
#> 2615 1471079
#> 2616 1474494
#> 2617 1475828
#> 2618 1478764
#> 2619 1478910
#> 2620 1478911
#> 2621 1481308
#> 2622 1481309
#> 2623 1481310
#> 2624 1481312
#> 2625 1481313
#> 2626 1481314
#> 2627 1481316
#> 2628 1481317
#> 2629 1481318
#> 2630 1481319
#> 2631 1481320
#> 2632 1481321
#> 2633 1481322
#> 2634 1481323
#> 2635 1481324
#> 2636 1481325
#> 2637 1481326
#> 2638 1481327
#> 2639 1481328
#> 2640 1481329
#> 2641 1481330
#> 2642 1481331
#> 2643 1481340
#> 2644 1481341
#> 2645 1481350
#> 2646 1481351
#> 2647 1481353
#> 2648 1481354
#> 2649 1481355
#> 2650 1481356
#> 2651 1481357
#> 2652 1481358
#> 2653 1481361
#> 2654 1481362
#> 2655 1481363
#> 2656 1481364
#> 2657 1481365
#> 2658 1481366
#> 2659 1481367
#> 2660 1481368
#> 2661 1481369
#> 2662 1481370
#> 2663 1481371
#> 2664 1481372
#> 2665 1481373
#> 2666 1481374
#> 2667 1481375
#> 2668 1481376
#> 2669 1481377
#> 2670 1481378
#> 2671 1481379
#> 2672 1481380
#> 2673 1481381
#> 2674 1481382
#> 2675 1481383
#> 2676 1481384
#> 2677 1481385
#> 2678 1481386
#> 2679 1481427
#> 2680 1481428
#> 2681 1481429
#> 2682 1481430
#> 2683 1481431
#> 2684 1481432
#> 2685 1483363
#> 2686 1483364
#> 2687 1483365
#> 2688 1483366
#> 2689 1483367
#> 2690 1483368
#> 2691 1483369
#> 2692 1483370
#> 2693 1483375
#> 2694 1483376
#> 2695 1483377
#> 2696 1483378
#> 2697 1483379
#> 2698 1483380
#> 2699 1483385
#> 2700 1483386
#> 2701 1483387
#> 2702 1483388
#> 2703 1483389
#> 2704 1483390
#> 2705 1483391
#> 2706 1483410
#> 2707 1483411
#> 2708 1483412
#> 2709 1484432
#> 2710 1484433
#> 2711 1484434
#> 2712 1484894
#> 2713 1484895
#> 2714 1485537
#> 2715 1488002
#> 2716 1488003
#> 2717 1488004
#> 2718 1488207
#> 2719 1488208
#> 2720 1488209
#> 2721 1488516
#> 2722 1488737
#> 2723 1488746
#> 2724 1490106
#> 2725 1490107
#> 2726 1491837
#> 2727 1491838
#> 2728 1492056
#> 2729 1492163
#> 2730 1492192
#> 2731 1492283
#> 2732 1492390
#> 2733 1492412
#> 2734 1492507
#> 2735 1492556
#> 2736 1492632
#> 2737 1492672
#> 2738 1492990
#> 2739 1493616
#> 2740 1494799
#> 2741 1497678
#> 2742 1497679
#> 2743 1497680
#> 2744 1497681
#> 2745 1497682
#> 2746 1497683
#> 2747 1497684
#> 2748 1497691
#> 2749 1497692
#> 2750 1497693
#> 2751 1497694
#> 2752 1498599
#> 2753 1498600
#> 2754 1498606
#> 2755 1498607
#> 2756 1498608
#> 2757 1498609
#> 2758 1498610
#> 2759 1498611
#> 2760 1499230
#> 2761 1499231
#> 2762 1499233
#> 2763 1499598
#> 2764 1499599
#> 2765 1499600
#> 2766 1499601
#> 2767 1499602
#> 2768 1499603
#> 2769 1499604
#> 2770 1499605
#> 2771 1499606
#> 2772 1500166
#> 2773 1500431
#> 2774 1502391
#> 2775 1503435
#> 2776 1503436
#> 2777 1504166
#> 2778 1504753
#> 2779 1507120
#> 2780 1507441
#> 2781 1507444
#> 2782 1507448
#> 2783 1507462
#> 2784 1508705
#> 2785 1508706
#> 2786 1508844
#> 2787 1509627
#> 2788 1510874
#> 2789 1511366
#> 2790 1511394
#> 2791 1511583
#> 2792 1511584
#> 2793 1511585
#> 2794 1511586
#> 2795 1511587
#> 2796 1511588
#> 2797 1511589
#> 2798 1511590
#> 2799 1511591
#> 2800 1511592
#> 2801 1511593
#> 2802 1511594
#> 2803 1513293
#> 2804 1516620
#> 2805 1516673
#> 2806 1517030
#> 2807 1517249
#> 2808 1518420
#> 2809 1518421
#> 2810 1518422
#> 2811 1518423
#> 2812 1518424
#> 2813 1519080
#> 2814 1519106
#> 2815 1519413
#> 2816 1519414
#> 2817 1519441
#> 2818 1519442
#> 2819 1520225
#> 2820 1525532
#> 2821 1527516
#> 2822 1527518
#> 2823 1528993
#> 2824 1529017
#> 2825 1529900
#> 2826 1530946
#> 2827 1531306
#> 2828 1531670
#> 2829 1532891
#> 2830 1532893
#> 2831 1533594
#> 2832 1534219
#> 2833 1535422
#> 2834 1535423
#> 2835 1535424
#> 2836 1535425
#> 2837 1535426
#> 2838 1535427
#> 2839 1535438
#> 2840 1535442
#> 2841 1535504
#> 2842 1536118
#> 2843 1536504
#> 2844 1536505
#> 2845 1536506
#> 2846 1536507
#> 2847 1536508
#> 2848 1536509
#> 2849 1536510
#> 2850 1536511
#> 2851 1536512
#> 2852 1536513
#> 2853 1536514
#> 2854 1536515
#> 2855 1538060
#> 2856 1538061
#> 2857 1538062
#> 2858 1538063
#> 2859 1538064
#> 2860 1538771
#> 2861 1539887
#> 2862 1539888
#> 2863 1539889
#> 2864 1539890
#> 2865 1539891
#> 2866 1540476
#> 2867 1541723
#> 2868 1542170
#> 2869 1542831
#> 2870 1542926
#> 2871 1543469
#> 2872 1543716
#> 2873 1544356
#> 2874 1544357
#> 2875 1544720
#> 2876 1544721
#> 2877 1544759
#> 2878 1545164
#> 2879 1545376
#> 2880 1545466
#> 2881 1545469
#> 2882 1545470
#> 2883 1545471
#> 2884 1545472
#> 2885 1545473
#> 2886 1545474
#> 2887 1545475
#> 2888 1545476
#> 2889 1545477
#> 2890 1545478
#> 2891 1545480
#> 2892 1545481
#> 2893 1545484
#> 2894 1545485
#> 2895 1545486
#> 2896 1545489
#> 2897 1545497
#> 2898 1545522
#> 2899 1548404
#> 2900 1548406
#> 2901 1549279
#> 2902 1549564
#> 2903 1550199
#> 2904 1550200
#> 2905 1550517
#> 2906 1550976
#> 2907 1551638
#> 2908 1551665
#> 2909 1551765
#> 2910 1551768
#> 2911 1551769
#> 2912 1552893
#> 2913 1553448
#> 2914 1554252
#> 2915 1554253
#> 2916 1554254
#> 2917 1554255
#> 2918 1554256
#> 2919 1554763
#> 2920 1555636
#> 2921 1555842
#> 2922 1555843
#> 2923 1556671
#> 2924 1557565
#> 2925 1558400
#> 2926 1559935
#> 2927 1560155
#> 2928 1560156
#> 2929 1560157
#> 2930 1560158
#> 2931 1560159
#> 2932 1560160
#> 2933 1560161
#> 2934 1560162
#> 2935 1560163
#> 2936 1560164
#> 2937 1560165
#> 2938 1560166
#> 2939 1560826
#> 2940 1560842
#> 2941 1561646
#> 2942 1561647
#> 2943 1562643
#> 2944 1562644
#> 2945 1562645
#> 2946 1562646
#> 2947 1562647
#> 2948 1562648
#> 2949 1562649
#> 2950 1562650
#> 2951 1562651
#> 2952 1562652
#> 2953 1562653
#> 2954 1562654
#> 2955 1562655
#> 2956 1563732
#> 2957 1563733
#> 2958 1564219
#> 2959 1564228
#> 2960 1564389
#> 2961 1565409
#> 2962 1565421
#> 2963 1565422
#> 2964 1565423
#> 2965 1565424
#> 2966 1565425
#> 2967 1565431
#> 2968 1565432
#> 2969 1565433
#> 2970 1565434
#> 2971 1565435
#> 2972 1565436
#> 2973 1565438
#> 2974 1567753
#> 2975 1567754
#> 2976 1567755
#> 2977 1567756
#> 2978 1567757
#> 2979 1567758
#> 2980 1567759
#> 2981 1567760
#> 2982 1567761
#> 2983 1567762
#> 2984 1567763
#> 2985 1567764
#> 2986 1568440
#> 2987 1572261
#> 2988 1572263
#> 2989 1572264
#> 2990 1572286
#> 2991 1572652
#> 2992 1572752
#> 2993 1573270
#> 2994 1573285
#> 2995 1573349
#> 2996 1574235
#> 2997 1574928
#> 2998 1574929
#> 2999 1574930
#> 3000 1576796
#> 3001 1576797
#> 3002 1576798
#> 3003 1576799
#> 3004 1576941
#> 3005 1576959
#> 3006 1578256
#> 3007 1578257
#> 3008 1578258
#> 3009 1578326
#> 3010 1579440
#> 3011 1580125
#> 3012 1580126
#> 3013 1580127
#> 3014 1580189
#> 3015 1580190
#> 3016 1580191
#> 3017 1580192
#> 3018 1580193
#> 3019 1580194
#> 3020 1580220
#> 3021 1580221
#> 3022 1580222
#> 3023 1580223
#> 3024 1580224
#> 3025 1580528
#> 3026 1580946
#> 3027 1580947
#> 3028 1580948
#> 3029 1580949
#> 3030 1580950
#> 3031 1582348
#> 3032 1582365
#> 3033 1582366
#> 3034 1582367
#> 3035 1582368
#> 3036 1582370
#> 3037 1582371
#> 3038 1582372
#> 3039 1582373
#> 3040 1582374
#> 3041 1582375
#> 3042 1582376
#> 3043 1582377
#> 3044 1582378
#> 3045 1582379
#> 3046 1582380
#> 3047 1582381
#> 3048 1582382
#> 3049 1582383
#> 3050 1582384
#> 3051 1582385
#> 3052 1582386
#> 3053 1582387
#> 3054 1582388
#> 3055 1582389
#> 3056 1582390
#> 3057 1582391
#> 3058 1582392
#> 3059 1582393
#> 3060 1582394
#> 3061 1582395
#> 3062 1582398
#> 3063 1582399
#> 3064 1582400
#> 3065 1582401
#> 3066 1582402
#> 3067 1582403
#> 3068 1582404
#> 3069 1582405
#> 3070 1582406
#> 3071 1582407
#> 3072 1582408
#> 3073 1582409
#> 3074 1582410
#> 3075 1582411
#> 3076 1582412
#> 3077 1582413
#> 3078 1582414
#> 3079 1582415
#> 3080 1582416
#> 3081 1582417
#> 3082 1582418
#> 3083 1582419
#> 3084 1582420
#> 3085 1582421
#> 3086 1582422
#> 3087 1582423
#> 3088 1582424
#> 3089 1582425
#> 3090 1582426
#> 3091 1582427
#> 3092 1582428
#> 3093 1582429
#> 3094 1582430
#> 3095 1582431
#> 3096 1582432
#> 3097 1582433
#> 3098 1582434
#> 3099 1582435
#> 3100 1582436
#> 3101 1582437
#> 3102 1582438
#> 3103 1582439
#> 3104 1582440
#> 3105 1582442
#> 3106 1582443
#> 3107 1583836
#> 3108 1583837
#> 3109 1583838
#> 3110 1583839
#> 3111 1583840
#> 3112 1583841
#> 3113 1583844
#> 3114 1583845
#> 3115 1583851
#> 3116 1583854
#> 3117 1583855
#> 3118 1583862
#> 3119 1583863
#> 3120 1583865
#> 3121 1583867
#> 3122 1583869
#> 3123 1583870
#> 3124 1584016
#> 3125 1584017
#> 3126 1584018
#> 3127 1584019
#> 3128 1584020
#> 3129 1584021
#> 3130 1584022
#> 3131 1584023
#> 3132 1584024
#> 3133 1584025
#> 3134 1584026
#> 3135 1584027
#> 3136 1584395
#> 3137 1585296
#> 3138 1585297
#> 3139 1585298
#> 3140 1585300
#> 3141 1585301
#> 3142 1585302
#> 3143 1585303
#> 3144 1585919
#> 3145 1585920
#> 3146 1585964
#> 3147 1585965
#> 3148 1585966
#> 3149 1585970
#> 3150 1585971
#> 3151 1585972
#> 3152 1585980
#> 3153 1585981
#> 3154 1585982
#> 3155 1586668
#> 3156 1586911
#> 3157 1587023
#> 3158 1587025
#> 3159 1588684
#> 3160 1588685
#> 3161 1588959
#> 3162 1589886
#> 3163 1589887
#> 3164 1589904
#> 3165 1589905
#> 3166 1589906
#> 3167 1589907
#> 3168 1589908
#> 3169 1589909
#> 3170 1589910
#> 3171 1589911
#> 3172 1589912
#> 3173 1589913
#> 3174 1589914
#> 3175 1589920
#> 3176 1589921
#> 3177 1589922
#> 3178 1589923
#> 3179 1589924
#> 3180 1589925
#> 3181 1590557
#> 3182 1590558
#> 3183 1590559
#> 3184 1590560
#> 3185 1590561
#> 3186 1590562
#> 3187 1590563
#> 3188 1590564
#> 3189 1590565
#> 3190 1590566
#> 3191 1590567
#> 3192 1590568
#> 3193 1591034
#> 3194 1591035
#> 3195 1591036
#> 3196 1591037
#> 3197 1591038
#> 3198 1591039
#> 3199 1591040
#> 3200 1591041
#> 3201 1591042
#> 3202 1591043
#> 3203 1591044
#> 3204 1591045
#> 3205 1591631
#> 3206 1592583
#> 3207 1592584
#> 3208 1592585
#> 3209 1592586
#> 3210 1592587
#> 3211 1592588
#> 3212 1592589
#> 3213 1592590
#> 3214 1592591
#> 3215 1592592
#> 3216 1592593
#> 3217 1592594
#> 3218 1594502
#> 3219 1594503
#> 3220 1595473
#> 3221 1595474
#> 3222 1595475
#> 3223 1595476
#> 3224 1595477
#> 3225 1595478
#> 3226 1595485
#> 3227 1595486
#> 3228 1595487
#> 3229 1595488
#> 3230 1595615
#> 3231 1595618
#> 3232 1595620
#> 3233 1595637
#> 3234 1595638
#> 3235 1595639
#> 3236 1595644
#> 3237 1595651
#> 3238 1596990
#> 3239 1597221
#> 3240 1598163
#> 3241 1599509
#> 3242 1599511
#> 3243 1599794
#> 3244 1599795
#> 3245 1599836
#> 3246 1599837
#> 3247 1599838
#> 3248 1599843
#> 3249 1599844
#> 3250 1599893
#> 3251 1599932
#> 3252 1599941
#> 3253 1599942
#> 3254 1599945
#> 3255 1599946
#> 3256 1599950
#> 3257 1599951
#> 3258 1599952
#> 3259 1600531
#> 3260 1600532
#> 3261 1600798
#> 3262 1601052
#> 3263 1601320
#> 3264 1602519
#> 3265 1602520
#> 3266 1602521
#> 3267 1602522
#> 3268 1602523
#> 3269 1602524
#> 3270 1602525
#> 3271 1602526
#> 3272 1602527
#> 3273 1603711
#> 3274 1606161
#> 3275 1607642
#> 3276 1607643
#> 3277 1608248
#> 3278 1608655
#> 3279 1608656
#> 3280 1608657
#> 3281 1608658
#> 3282 1609522
#> 3283 1610896
#> 3284 1610897
#> 3285 1610943
#> 3286 1610967
#> 3287 1610968
#> 3288 1610969
#> 3289 1611097
#> 3290 1611104
#> 3291 1611560
#> 3292 1611561
#> 3293 1611562
#> 3294 1611563
#> 3295 1611564
#> 3296 1611565
#> 3297 1611566
#> 3298 1611567
#> 3299 1611568
#> 3300 1612545
#> 3301 1612546
#> 3302 1612890
#> 3303 1612891
#> 3304 1612896
#> 3305 1612929
#> 3306 1612959
#> 3307 1612989
#> 3308 1613109
#> 3309 1614789
#> 3310 1614797
#> 3311 1615345
#> 3312 1615387
#> 3313 1616553
#> 3314 1616555
#> 3315 1616556
#> 3316 1616559
#> 3317 1616561
#> 3318 1616564
#> 3319 1616575
#> 3320 1616576
#> 3321 1616577
#> 3322 1616578
#> 3323 1616579
#> 3324 1616580
#> 3325 1616581
#> 3326 1616582
#> 3327 1616583
#> 3328 1616584
#> 3329 1616585
#> 3330 1616586
#> 3331 1616601
#> 3332 1616603
#> 3333 1616948
#> 3334 1617466
#> 3335 1617467
#> 3336 1617468
#> 3337 1617954
#> 3338 1617955
#> 3339 1617956
#> 3340 1617957
#> 3341 1617959
#> 3342 1617960
#> 3343 1617961
#> 3344 1617975
#> 3345 1617981
#> 3346 1617982
#> 3347 1617983
#> 3348 1618015
#> 3349 1618026
#> 3350 1620788
#> 3351 1625022
#> 3352 1625319
#> 3353 1625320
#> 3354 1625325
#> 3355 1625327
#> 3356 1627085
#> 3357 1627086
#> 3358 1627091
#> 3359 1627092
#> 3360 1627104
#> 3361 1627105
#> 3362 1627106
#> 3363 1627692
#> 3364 1627748
#> 3365 1629483
#> 3366 1630435
#> 3367 1630436
#> 3368 1630438
#> 3369 1630439
#> 3370 1631222
#> 3371 1632290
#> 3372 1632301
#> 3373 1632327
#> 3374 1633243
#> 3375 1636724
#> 3376 1636808
#> 3377 1636809
#> 3378 1637072
#> 3379 1637540
#> 3380 1638787
#> 3381 1638788
#> 3382 1646570
#> 3383 1646613
#> 3384 1646614
#> 3385 1646615
#> 3386 1646616
#> 3387 1646617
#> 3388 1646945
#> 3389 1646966
#> 3390 1649859
#> 3391 1649860
#> 3392 1649861
#> 3393 1649862
#> 3394 1649863
#> 3395 1649864
#> 3396 1649865
#> 3397 1652200
#> 3398 1654042
#> 3399 1656256
#> 3400 1656714
#> 3401 1656715
#> 3402 1656985
#> 3403 1658303
#> 3404 1658308
#> 3405 1658309
#> 3406 1658312
#> 3407 1658313
#> 3408 1658315
#> 3409 1658316
#> 3410 1658317
#> 3411 1658318
#> 3412 1658319
#> 3413 1658320
#> 3414 1658321
#> 3415 1658322
#> 3416 1658323
#> 3417 1658324
#> 3418 1658325
#> 3419 1658326
#> 3420 1658327
#> 3421 1658328
#> 3422 1658329
#> 3423 1659246
#> 3424 1659784
#> 3425 1659786
#> 3426 1659955
#> 3427 1659956
#> 3428 1659957
#> 3429 1659958
#> 3430 1659959
#> 3431 1659960
#> 3432 1659961
#> 3433 1659962
#> 3434 1659963
#> 3435 1659964
#> 3436 1659965
#> 3437 1659966
#> 3438 1659967
#> 3439 1659968
#> 3440 1659972
#> 3441 1659973
#> 3442 1659974
#> 3443 1664188
#> 3444 1664192
#> 3445 1664193
#> 3446 1664194
#> 3447 1664195
#> 3448 1664196
#> 3449 1664199
#> 3450 1664200
#> 3451 1664394
#> 3452 1664395
#> 3453 1664396
#> 3454 1664397
#> 3455 1664425
#> 3456 1664426
#> 3457 1664427
#> 3458 1667574
#> 3459 1667575
#> 3460 1667592
#> 3461 1672580
#> 3462 1672723
#> 3463 1672724
#> 3464 1672938
#> 3465 1673088
#> 3466 1673305
#> 3467 1673312
#> 3468 1673827
#> 3469 1673834
#> 3470 1673934
#> 3471 1676511
#> 3472 1676512
#> 3473 1676513
#> 3474 1676514
#> 3475 1676515
#> 3476 1676680
#> 3477 1676868
#> 3478 1676869
#> 3479 1677821
#> 3480 1677853
#> 3481 1679034
#> 3482 1679045
#> 3483 1679757
#> 3484 1688918
#> 3485 1688919
#> 3486 1689697
#> 3487 1690317
#> 3488 1690728
#> 3489 1690736
#> 3490 1690737
#> 3491 1690738
#> 3492 1690739
#> 3493 1690740
#> 3494 1690741
#> 3495 1690742
#> 3496 1690743
#> 3497 1690744
#> 3498 1690749
#> 3499 1691109
#> 3500 1691110
#> 3501 1691112
#> 3502 1691113
#> 3503 1691116
#> 3504 1691117
#> 3505 1691118
#> 3506 1691119
#> 3507 1691120
#> 3508 1691121
#> 3509 1691122
#> 3510 1691125
#> 3511 1691126
#> 3512 1691127
#> 3513 1691128
#> 3514 1691129
#> 3515 1691130
#> 3516 1691131
#> 3517 1691132
#> 3518 1691133
#> 3519 1691134
#> 3520 1691135
#> 3521 1691136
#> 3522 1691137
#> 3523 1691139
#> 3524 1691140
#> 3525 1691141
#> 3526 1691142
#> 3527 1691143
#> 3528 1691144
#> 3529 1691145
#> 3530 1691384
#> 3531 1693246
#> 3532 1695555
#> 3533 1697063
#> 3534 1699720
#> 3535 1699735
#> 3536 1702613
#> 3537 1702614
#> 3538 1702615
#> 3539 1702616
#> 3540 1703381
#> 3541 1703398
#> 3542 1704357
#> 3543 1704927
#> 3544 1704928
#> 3545 1704929
#> 3546 1704930
#> 3547 1704931
#> 3548 1704939
#> 3549 1704940
#> 3550 1704941
#> 3551 1704942
#> 3552 1704943
#> 3553 1704944
#> 3554 1704945
#> 3555 1704946
#> 3556 1704947
#> 3557 1704948
#> 3558 1704949
#> 3559 1704950
#> 3560 1704951
#> 3561 1704952
#> 3562 1704953
#> 3563 1704954
#> 3564 1704955
#> 3565 1704956
#> 3566 1704957
#> 3567 1704960
#> 3568 1704961
#> 3569 1704962
#> 3570 1704963
#> 3571 1704964
#> 3572 1704965
#> 3573 1704966
#> 3574 1704967
#> 3575 1704968
#> 3576 1704969
#> 3577 1704970
#> 3578 1704971
#> 3579 1704972
#> 3580 1704973
#> 3581 1704974
#> 3582 1704975
#> 3583 1704976
#> 3584 1704977
#> 3585 1704978
#> 3586 1706939
#> 3587 1708147
#> 3588 1708236
#> 3589 1708237
#> 3590 1708238
#> 3591 1708302
#> 3592 1709289
#> 3593 1709292
#> 3594 1709313
#> 3595 1709314
#> 3596 1709316
#> 3597 1709459
#> 3598 1710199
#> 3599 1710850
#> 3600 1710851
#> 3601 1711467
#> 3602 1712123
#> 3603 1713436
#> 3604 1713454
#> 3605 1713455
#> 3606 1713456
#> 3607 1713467
#> 3608 1713705
#> 3609 1714838
#> 3610 1715121
#> 3611 1715371
#> 3612 1715723
#> 3613 1715787
#> 3614 1715788
#> 3615 1715789
#> 3616 1715791
#> 3617 1715796
#> 3618 1715979
#> 3619 1717446
#> 3620 1717447
#> 3621 1717448
#> 3622 1717449
#> 3623 1718804
#> 3624 1718805
#> 3625 1718891
#> 3626 1718992
#> 3627 1718993
#> 3628 1719557
#> 3629 1719558
#> 3630 1719559
#> 3631 1719560
#> 3632 1719561
#> 3633 1719562
#> 3634 1719563
#> 3635 1719564
#> 3636 1720107
#> 3637 1720112
#> 3638 1720507
#> 3639 1720509
#> 3640 1720514
#> 3641 1720530
#> 3642 1721874
#> 3643 1723351
#> 3644 1723352
#> 3645 1724039
#> 3646 1724046
#> 3647 1724051
#> 3648 1724473
#> 3649 1724474
#> 3650 1724534
#> 3651 1724535
#> 3652 1724536
#> 3653 1724541
#> 3654 1724542
#> 3655 1724543
#> 3656 1724890
#> 3657 1724891
#> 3658 1724899
#> 3659 1724914
#> 3660 1724922
#> 3661 1724925
#> 3662 1726708
#> 3663 1726709
#> 3664 1726716
#> 3665 1730437
#> 3666 1730445
#> 3667 1730446
#> 3668 1730447
#> 3669 1730448
#> 3670 1730449
#> 3671 1730450
#> 3672 1730451
#> 3673 1730452
#> 3674 1730458
#> 3675 1730459
#> 3676 1730460
#> 3677 1730461
#> 3678 1730462
#> 3679 1730463
#> 3680 1730464
#> 3681 1730858
#> 3682 1730859
#> 3683 1730860
#> 3684 1730865
#> 3685 1730866
#> 3686 1730883
#> 3687 1730885
#> 3688 1730886
#> 3689 1730888
#> 3690 1730889
#> 3691 1730891
#> 3692 1730892
#> 3693 1731395
#> 3694 1731397
#> 3695 1731979
#> 3696 1734767
#> 3697 1734769
#> 3698 1735358
#> 3699 1737847
#> 3700 1738031
#> 3701 1738032
#> 3702 1738033
#> 3703 1738568
#> 3704 1738669
#> 3705 1738670
#> 3706 1738671
#> 3707 1738675
#> 3708 1738676
#> 3709 1738683
#> 3710 1738684
#> 3711 1738685
#> 3712 1738686
#> 3713 1738687
#> 3714 1738688
#> 3715 1738689
#> 3716 1738690
#> 3717 1738691
#> 3718 1738692
#> 3719 1739679
#> 3720 1739959
#> 3721 1739960
#> 3722 1739964
#> 3723 1739965
#> 3724 1740136
#> 3725 1740137
#> 3726 1740138
#> 3727 1740139
#> 3728 1740140
#> 3729 1740141
#> 3730 1740143
#> 3731 1740144
#> 3732 1740145
#> 3733 1740146
#> 3734 1740147
#> 3735 1740149
#> 3736 1741603
#> 3737 1742783
#> 3738 1743535
#> 3739 1743741
#> 3740 1746461
#> 3741 1746462
#> 3742 1746463
#> 3743 1746464
#> 3744 1746465
#> 3745 1746466
#> 3746 1746467
#> 3747 1746468
#> 3748 1746469
#> 3749 1746470
#> 3750 1746471
#> 3751 1746472
#> 3752 1747049
#> 3753 1747050
#> 3754 1747051
#> 3755 1747052
#> 3756 1747053
#> 3757 1747054
#> 3758 1747055
#> 3759 1747056
#> 3760 1747057
#> 3761 1747058
#> 3762 1747059
#> 3763 1747060
#> 3764 1747475
#> 3765 1747476
#> 3766 1747477
#> 3767 1747478
#> 3768 1747479
#> 3769 1747480
#> 3770 1747481
#> 3771 1747482
#> 3772 1747483
#> 3773 1747484
#> 3774 1747485
#> 3775 1747486
#> 3776 1747905
#> 3777 1748066
#> 3778 1748067
#> 3779 1748068
#> 3780 1748069
#> 3781 1748070
#> 3782 1748071
#> 3783 1748072
#> 3784 1748073
#> 3785 1748074
#> 3786 1748075
#> 3787 1748076
#> 3788 1748077
#> 3789 1749383
#> 3790 1750396
#> 3791 1751280
#> 3792 1751281
#> 3793 1751473
#> 3794 1752176
#> 3795 1753429
#> 3796 1753430
#> 3797 1753431
#> 3798 1755834
#> 3799 1756967
#> 3800 1756968
#> 3801 1756972
#> 3802 1756991
#> 3803 1756992
#> 3804 1756993
#> 3805 1756994
#> 3806 1756995
#> 3807 1756996
#> 3808 1757018
#> 3809 1757235
#> 3810 1757237
#> 3811 1757409
#> 3812 1757439
#> 3813 1758203
#> 3814 1760291
#> 3815 1760294
#> 3816 1760612
#> 3817 1760613
#> 3818 1760614
#> 3819 1760615
#> 3820 1762240
#> 3821 1764517
#> 3822 1765422
#> 3823 1765423
#> 3824 1766922
#> 3825 1766923
#> 3826 1766924
#> 3827 1766925
#> 3828 1766926
#> 3829 1766927
#> 3830 1766928
#> 3831 1766929
#> 3832 1766930
#> 3833 1766931
#> 3834 1766932
#> 3835 1766933
#> 3836 1766934
#> 3837 1766936
#> 3838 1766937
#> 3839 1766938
#> 3840 1766939
#> 3841 1766940
#> 3842 1766949
#> 3843 1766950
#> 3844 1766951
#> 3845 1766952
#> 3846 1766953
#> 3847 1766954
#> 3848 1766955
#> 3849 1766957
#> 3850 1768123
#> 3851 1769046
#> 3852 1769053
#> 3853 1769056
#> 3854 1769799
#> 3855 1770181
#> 3856 1770182
#> 3857 1770183
#> 3858 1770184
#> 3859 1770185
#> 3860 1770186
#> 3861 1770187
#> 3862 1770188
#> 3863 1770189
#> 3864 1770190
#> 3865 1770191
#> 3866 1770192
#> 3867 1770193
#> 3868 1770194
#> 3869 1770240
#> 3870 1770241
#> 3871 1770245
#> 3872 1770246
#> 3873 1770247
#> 3874 1770248
#> 3875 1771671
#> 3876 1771672
#> 3877 1771673
#> 3878 1771674
#> 3879 1771675
#> 3880 1771676
#> 3881 1771694
#> 3882 1771695
#> 3883 1771696
#> 3884 1771697
#> 3885 1771698
#> 3886 1771699
#> 3887 1771700
#> 3888 1771701
#> 3889 1771702
#> 3890 1771703
#> 3891 1771720
#> 3892 1771721
#> 3893 1771722
#> 3894 1771723
#> 3895 1771724
#> 3896 1771729
#> 3897 1772706
#> 3898 1772707
#> 3899 1772708
#> 3900 1772709
#> 3901 1772744
#> 3902 1772745
#> 3903 1772778
#> 3904 1772779
#> 3905 1772780
#> 3906 1772900
#> 3907 1772909
#> 3908 1772920
#> 3909 1772921
#> 3910 1772922
#> 3911 1773379
#> 3912 1775724
#> 3913 1776223
#> 3914 1776225
#> 3915 1776908
#> 3916 1777020
#> 3917 1778613
#> 3918 1779644
#> 3919 1780856
#> 3920 1781602
#> 3921 1781999
#> 3922 1784108
#> 3923 1784184
#> 3924 1784553
#> 3925 1784556
#> 3926 1784557
#> 3927 1784562
#> 3928 1784591
#> 3929 1784593
#> 3930 1784612
#> 3931 1785056
#> 3932 1785942
#> 3933 1785943
#> 3934 1786376
#> 3935 1786832
#> 3936 1787124
#> 3937 1787306
#> 3938 1787623
#> 3939 1788980
#> 3940 1789257
#> 3941 1789668
#> 3942 1789731
#> 3943 1790049
#> 3944 1790164
#> 3945 1790165
#> 3946 1790166
#> 3947 1790167
#> 3948 1790168
#> 3949 1790482
#> 3950 1790553
#> 3951 1790653
#> 3952 1790985
#> 3953 1790986
#> 3954 1790987
#> 3955 1790988
#> 3956 1790989
#> 3957 1791476
#> 3958 1791587
#> 3959 1792259
#> 3960 1792260
#> 3961 1792261
#> 3962 1792262
#> 3963 1792263
#> 3964 1792264
#> 3965 1792265
#> 3966 1792266
#> 3967 1792267
#> 3968 1792268
#> 3969 1792269
#> 3970 1792659
#> 3971 1793069
#> 3972 1793363
#> 3973 1793654
#> 3974 1794053
#> 3975 1794054
#> 3976 1794055
#> 3977 1794056
#> 3978 1794057
#> 3979 1794058
#> 3980 1794059
#> 3981 1794060
#> 3982 1794061
#> 3983 1794062
#> 3984 1794063
#> 3985 1794064
#> 3986 1794473
#> 3987 1794553
#> 3988 1794871
#> 3989 1795051
#> 3990 1795071
#> 3991 1795072
#> 3992 1795073
#> 3993 1795123
#> 3994 1795309
#> 3995 1795419
#> 3996 1795424
#> 3997 1795439
#> 3998 1795457
#> 3999 1795505
#> 4000 1795513
#> 4001 1795518
#> 4002 1795540
#> 4003 1795546
#> 4004 1795547
#> 4005 1795551
#> 4006 1795552
#> 4007 1795555
#> 4008 1795556
#> 4009 1795558
#> 4010 1795584
#> 4011 1795588
#> 4012 1795591
#> 4013 1795628
#> 4014 1795632
#> 4015 1795635
#> 4016 1795638
#> 4017 1795646
#> 4018 1795660
#> 4019 1795681
#> 4020 1795684
#> 4021 1795688
#> 4022 1795704
#> 4023 1795705
#> 4024 1795712
#> 4025 1795741
#> 4026 1795746
#> 4027 1795747
#> 4028 1795752
#> 4029 1795753
#> 4030 1795774
#> 4031 1795775
#> 4032 1795856
#> 4033 1795889
#> 4034 1795895
#> 4035 1795900
#> 4036 1795920
#> 4037 1795974
#> 4038 1796250
#> 4039 1796430
#> 4040 1796550
#> 4041 1796605
#> 4042 1796863
#> 4043 1796887
#> 4044 1796911
#> 4045 1796957
#> 4046 1797176
#> 4047 1797252
#> 4048 1797253
#> 4049 1797254
#> 4050 1797255
#> 4051 1797499
#> 4052 1798057
#> 4053 1798058
#> 4054 1798059
#> 4055 1798060
#> 4056 1798141
#> 4057 1798142
#> 4058 1798244
#> 4059 1798381
#> 4060 1798403
#> 4061 1798470
#> 4062 1798474
#> 4063 1798578
#> 4064 1798633
#> 4065 1798634
#> 4066 1798858
#> 4067 1798859
#> 4068 1798869
#> 4069 1798897
#> 4070 1798900
#> 4071 1799141
#> 4072 1799178
#> 4073 1799243
#> 4074 1799574
#> 4075 1799615
#> 4076 1799617
#> 4077 1799625
#> 4078 1799771
#> 4079 1799815
#> 4080 1800017
#> 4081 1800264
#> 4082 1800296
#> 4083 1800438
#> 4084 1800686
#> 4085 1800785
#> 4086 1800803
#> 4087 1800956
#> 4088 1801080
#> 4089 1801412
#> 4090 1801434
#> 4091 1801474
#> 4092 1801647
#> 4093 1801868
#> 4094 1801874
#> 4095 1801898
#> 4096 1802136
#> 4097 1802137
#> 4098 1802325
#> 4099 1802525
#> 4100 1802578
#> 4101 1802918
#> 4102 1802919
#> 4103 1802936
#> 4104 1802974
#> 4105 1802992
#> 4106 1803023
#> 4107 1803024
#> 4108 1803025
#> 4109 1803088
#> 4110 1803154
#> 4111 1803180
#> 4112 1803181
#> 4113 1803203
#> 4114 1803274
#> 4115 1803310
#> 4116 1803399
#> 4117 1803412
#> 4118 1803805
#> 4119 1803853
#> 4120 1803858
#> 4121 1804000
#> 4122 1804197
#> 4123 1804293
#> 4124 1804325
#> 4125 1804410
#> 4126 1804433
#> 4127 1804859
#> 4128 1804965
#> 4129 1804972
#> 4130 1804977
#> 4131 1805069
#> 4132 1805145
#> 4133 1805273
#> 4134 1805304
#> 4135 1805507
#> 4136 1805558
#> 4137 1805668
#> 4138 1805683
#> 4139 1805847
#> 4140 1805904
#> 4141 1805911
#> 4142 1805923
#> 4143 1806019
#> 4144 1806100
#> 4145 1806101
#> 4146 1806114
#> 4147 1806351
#> 4148 1806356
#> 4149 1806384
#> 4150 1806436
#> 4151 1806437
#> 4152 1806453
#> 4153 1806454
#> 4154 1806503
#> 4155 1806542
#> 4156 1806553
#> 4157 1806554
#> 4158 1806579
#> 4159 1806610
#> 4160 1806667
#> 4161 1806668
#> 4162 1806769
#> 4163 1806801
#> 4164 1807691
#> 4165 1807692
#> 4166 1807693
#> 4167 1807694
#> 4168 1807698
#> 4169 1807699
#> 4170 1807700
#> 4171 1807880
#> 4172 1809035
#> 4173 1809036
#> 4174 1809037
#> 4175 1809038
#> 4176 1809051
#> 4177 1809346
#> 4178 1809347
#> 4179 1809348
#> 4180 1809353
#> 4181 1809354
#> 4182 1809355
#> 4183 1809356
#> 4184 1809435
#> 4185 1809462
#> 4186 1809464
#> 4187 1810735
#> 4188 1811625
#> 4189 1811626
#> 4190 1811627
#> 4191 1811628
#> 4192 1811975
#> 4193 1812027
#> 4194 1812036
#> 4195 1812038
#> 4196 1812799
#> 4197 1812800
#> 4198 1812801
#> 4199 1812802
#> 4200 1813292
#> 4201 1813864
#> 4202 1813866
#> 4203 1813869
#> 4204 1813879
#> 4205 1813976
#> 4206 1814379
#> 4207 1815232
#> 4208 1815785
#> 4209 1815787
#> 4210 1815789
#> 4211 1816270
#> 4212 1817355
#> 4213 1817356
#> 4214 1817358
#> 4215 1817360
#> 4216 1817364
#> 4217 1817366
#> 4218 1817367
#> 4219 1817369
#> 4220 1817372
#> 4221 1820084
#> 4222 1821869
#> 4223 1822764
#> 4224 1822769
#> 4225 1822806
#> 4226 1822807
#> 4227 1823020
#> 4228 1824039
#> 4229 1824040
#> 4230 1824041
#> 4231 1825949
#> 4232 1825950
#> 4233 1825951
#> 4234 1825968
#> 4235 1825969
#> 4236 1830144
#> 4237 1830145
#> 4238 1830146
#> 4239 1830557
#> 4240 1834113
#> 4241 1834646
#> 4242 1834755
#> 4243 1834949
#> 4244 1835706
#> 4245 1845273
#> 4246 1845392
#> 4247 1846706
#> 4248 1846709
#> 4249 1846710
#> 4250 1846711
#> 4251 1846712
#> 4252 1846713
#> 4253 1846715
#> 4254 1846717
#> 4255 1846721
#> 4256 1846723
#> 4257 1846724
#> 4258 1846730
#> 4259 1846731
#> 4260 1846734
#> 4261 1846747
#> 4262 1846777
#> 4263 1846789
#> 4264 1846790
#> 4265 1846838
#> 4266 1848430
#> 4267 1848536
#> 4268 1848537
#> 4269 1849135
#> 4270 1849136
#> 4271 1849655
#> 4272 1850190
#> 4273 1851522
#> 4274 1853203
#> 4275 1855210
#> 4276 1855624
#> 4277 1855769
#> 4278 1856438
#> 4279 1857167
#> 4280 1857195
#> 4281 1858633
#> 4282 1858635
#> 4283 1859058
#> 4284 1859065
#> 4285 1859066
#> 4286 1859161
#> 4287 1859426
#> 4288 1859429
#> 4289 1859430
#> 4290 1859431
#> 4291 1859432
#> 4292 1859433
#> 4293 1859434
#> 4294 1859435
#> 4295 1860200
#> 4296 1860386
#> 4297 1860451
#> 4298 1860733
#> 4299 1860734
#> 4300 1860735
#> 4301 1860736
#> 4302 1860737
#> 4303 1860738
#> 4304 1860739
#> 4305 1860740
#> 4306 1860741
#> 4307 1860742
#> 4308 1860743
#> 4309 1860769
#> 4310 1860770
#> 4311 1861560
#> 4312 1861561
#> 4313 1861562
#> 4314 1861565
#> 4315 1861566
#> 4316 1861567
#> 4317 1861568
#> 4318 1861569
#> 4319 1861570
#> 4320 1861607
#> 4321 1861611
#> 4322 1861965
#> 4323 1861966
#> 4324 1861967
#> 4325 1861968
#> 4326 1861969
#> 4327 1862859
#> 4328 1862860
#> 4329 1862861
#> 4330 1862936
#> 4331 1862937
#> 4332 1864438
#> 4333 1864595
#> 4334 1865358
#> 4335 1865359
#> 4336 1865379
#> 4337 1865380
#> 4338 1865381
#> 4339 1865382
#> 4340 1865403
#> 4341 1865404
#> 4342 1865633
#> 4343 1865634
#> 4344 1865635
#> 4345 1865636
#> 4346 1865637
#> 4347 1865638
#> 4348 1865645
#> 4349 1866055
#> 4350 1866989
#> 4351 1867134
#> 4352 1867135
#> 4353 1867136
#> 4354 1867137
#> 4355 1867185
#> 4356 1867186
#> 4357 1867213
#> 4358 1867214
#> 4359 1867215
#> 4360 1867476
#> 4361 1867477
#> 4362 1867478
#> 4363 1867479
#> 4364 1870642
#> 4365 1870643
#> 4366 1870651
#> 4367 1870653
#> 4368 1870654
#> 4369 1870656
#> 4370 1870657
#> 4371 1870658
#> 4372 1871558
#> 4373 1871559
#> 4374 1871560
#> 4375 1871564
#> 4376 1871566
#> 4377 1871567
#> 4378 1871569
#> 4379 1871573
#> 4380 1871580
#> 4381 1871582
#> 4382 1871584
#> 4383 1871588
#> 4384 1871593
#> 4385 1871597
#> 4386 1871599
#> 4387 1871600
#> 4388 1871765
#> 4389 1872757
#> 4390 1873620
#> 4391 1874024
#> 4392 1875934
#> 4393 1876161
#> 4394 1876269
#> 4395 1877817
#> 4396 1877822
#> 4397 1877823
#> 4398 1877824
#> 4399 1877909
#> 4400 1878118
#> 4401 1880122
#> 4402 1880123
#> 4403 1880124
#> 4404 1880126
#> 4405 1880128
#> 4406 1880129
#> 4407 1880130
#> 4408 1880132
#> 4409 1880138
#> 4410 1880140
#> 4411 1880576
#> 4412 1880577
#> 4413 1880578
#> 4414 1880579
#> 4415 1880580
#> 4416 1880581
#> 4417 1880582
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#> 4419 1880584
#> 4420 1880585
#> 4421 1880586
#> 4422 1880588
#> 4423 1880589
#> 4424 1880590
#> 4425 1880591
#> 4426 1880592
#> 4427 1880593
#> 4428 1880594
#> 4429 1880595
#> 4430 1880596
#> 4431 1880597
#> 4432 1880598
#> 4433 1880599
#> 4434 1880600
#> 4435 1880601
#> 4436 1880602
#> 4437 1880603
#> 4438 1880604
#> 4439 1880605
#> 4440 1880606
#> 4441 1880607
#> 4442 1880608
#> 4443 1880609
#> 4444 1880610
#> 4445 1880611
#> 4446 1880612
#> 4447 1880613
#> 4448 1880614
#> 4449 1880615
#> 4450 1880616
#> 4451 1880617
#> 4452 1880618
#> 4453 1880619
#> 4454 1880620
#> 4455 1880621
#> 4456 1880622
#> 4457 1880627
#> 4458 1880628
#> 4459 1881816
#> 4460 1881817
#> 4461 1881819
#> 4462 1881820
#> 4463 1881821
#> 4464 1881822
#> 4465 1881823
#> 4466 1881824
#> 4467 1882134
#> 4468 1882139
#> 4469 1882140
#> 4470 1882141
#> 4471 1882145
#> 4472 1882626
#> 4473 1882627
#> 4474 1882632
#> 4475 1882637
#> 4476 1882641
#> 4477 1882645
#> 4478 1882646
#> 4479 1882652
#> 4480 1882655
#> 4481 1882660
#> 4482 1882661
#> 4483 1883959
#> 4484 1884418
#> 4485 1884788
#> 4486 1884789
#> 4487 1884790
#> 4488 1884791
#> 4489 1885339
#> 4490 1885341
#> 4491 1885342
#> 4492 1885343
#> 4493 1885371
#> 4494 1885372
#> 4495 1885373
#> 4496 1885374
#> 4497 1885375
#> 4498 1885376
#> 4499 1885377
#> 4500 1885486
#> 4501 1886715
#> 4502 1887635
#> 4503 1887636
#> 4504 1887637
#> 4505 1887639
#> 4506 1887642
#> 4507 1887643
#> 4508 1887647
#> 4509 1887648
#> 4510 1887649
#> 4511 1887680
#> 4512 1888970
#> 4513 1889499
#> 4514 1890815
#> 4515 1890816
#> 4516 1891048
#> 4517 1891050
#> 4518 1891069
#> 4519 1891383
#> 4520 1893104
#> 4521 1893379
#> 4522 1894146
#> 4523 1894148
#> 4524 1894149
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#> 4527 1894153
#> 4528 1894155
#> 4529 1894156
#> 4530 1894157
#> 4531 1894161
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#> 4533 1894624
#> 4534 1894678
#> 4535 1895668
#> 4536 1895673
#> 4537 1896769
#> 4538 1896770
#> 4539 1896771
#> 4540 1896772
#> 4541 1896773
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#> 4543 1896775
#> 4544 1896782
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#> 4546 1896785
#> 4547 1896786
#> 4548 1896787
#> 4549 1896788
#> 4550 1896791
#> 4551 1898317
#> 4552 1898661
#> 4553 1898662
#> 4554 1898665
#> 4555 1898666
#> 4556 1898674
#> 4557 1899709
#> 4558 1901540
#> 4559 1904029
#> 4560 1904122
#> 4561 1904299
#> 4562 1904300
#> 4563 1904301
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#> 4565 1904305
#> 4566 1904306
#> 4567 1904309
#> 4568 1904310
#> 4569 1904311
#> 4570 1904318
#> 4571 1904319
#> 4572 1904320
#> 4573 1904321
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#> 4575 1904323
#> 4576 1904324
#> 4577 1904325
#> 4578 1904326
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#> 4580 1904328
#> 4581 1904329
#> 4582 1904330
#> 4583 1904331
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#> 4585 1904333
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#> 4588 1904340
#> 4589 1904341
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#> 4591 1904343
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#> 4594 1904347
#> 4595 1904349
#> 4596 1904350
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#> 4599 1904353
#> 4600 1904473
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#> 4602 1904475
#> 4603 1904478
#> 4604 1904544
#> 4605 1904545
#> 4606 1904552
#> 4607 1904555
#> 4608 1904558
#> 4609 1904561
#> 4610 1904564
#> 4611 1905727
#> 4612 1905794
#> 4613 1908699
#> 4614 1909240
#> 4615 1909241
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#> 4619 1909251
#> 4620 1909685
#> 4621 1909886
#> 4622 1909888
#> 4623 1909890
#> 4624 1909899
#> 4625 1910562
#> 4626 1912865
#> 4627 1913054
#> 4628 1913374
#> 4629 1913459
#> 4630 1913505
#> 4631 1913676
#> 4632 1913717
#> 4633 1913718
#> 4634 1913804
#> 4635 1913805
#> 4636 1913871
#> 4637 1914046
#> 4638 1914053
#> 4639 1914125
#> 4640 1914203
#> 4641 1914311
#> 4642 1914653
#> 4643 1914684
#> 4644 1914919
#> 4645 1914976
#> 4646 1915188
#> 4647 1915407
#> 4648 1915408
#> 4649 1915409
#> 4650 1915410
#> 4651 1915467
#> 4652 1915468
#> 4653 1915469
#> 4654 1915535
#> 4655 1915572
#> 4656 1915575
#> 4657 1915576
#> 4658 1915577
#> 4659 1915677
#> 4660 1915678
#> 4661 1915679
#> 4662 1915685
#> 4663 1915688
#> 4664 1915689
#> 4665 1915690
#> 4666 1915691
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#> 4668 1915693
#> 4669 1915694
#> 4670 1915697
#> 4671 1915698
#> 4672 1915699
#> 4673 1915705
#> 4674 1915719
#> 4675 1916784
#> 4676 1919057
#> 4677 1919092
#> 4678 1919093
#> 4679 1919180
#> 4680 1919215
#> 4681 1919300
#> 4682 1919455
#> 4683 1919495
#> 4684 1919607
#> 4685 1919644
#> 4686 1919678
#> 4687 1919849
#> 4688 1919856
#> 4689 1919928
#> 4690 1919985
#> 4691 1919999
#> 4692 1920013
#> 4693 1920045
#> 4694 1920191
#> 4695 1921360
#> 4696 1921363
#> 4697 1921364
#> 4698 1921814
#> 4699 1921815
#> 4700 1921816
#> 4701 1922095
#> 4702 1922295
#> 4703 1923076
#> 4704 1923183
#> 4705 1924191
#> 4706 1924659
#> 4707 1925327
#> 4708 1925450
#> 4709 1925467
#> 4710 1925476
#> 4711 1925478
#> 4712 1925485
#> 4713 1925497
#> 4714 1925499
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#> 4717 1925517
#> 4718 1927458
#> 4719 1927644
#> 4720 1927645
#> 4721 1927646
#> 4722 1927647
#> 4723 1927649
#> 4724 1927651
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#> 4727 1927669
#> 4728 1927678
#> 4729 1927684
#> 4730 1927685
#> 4731 1927691
#> 4732 1927695
#> 4733 1927699
#> 4734 1927701
#> 4735 1927702
#> 4736 1927705
#> 4737 1927706
#> 4738 1927707
#> 4739 1927712
#> 4740 1927714
#> 4741 1927715
#> 4742 1927716
#> 4743 1927717
#> 4744 1928276
#> 4745 1928914
#> 4746 1929371
#> 4747 1929375
#> 4748 1930037
#> 4749 1930755
#> 4750 1930756
#> 4751 1933403
#> 4752 1934726
#> 4753 1934848
#> 4754 1935444
#> 4755 1935462
#> 4756 1935464
#> 4757 1936611
#> 4758 1936712
#> 4759 1937347
#> 4760 1937700
#> 4761 1937704
#> 4762 1937919
#> 4763 1937920
#> 4764 1939172
#> 4765 1939174
#> 4766 1939436
#> 4767 1939605
#> 4768 1939975
#> 4769 1939977
#> 4770 1939981
#> 4771 1939982
#> 4772 1939983
#> 4773 1939984
#> 4774 1940017
#> 4775 1940255
#> 4776 1940841
#> 4777 1941740
#> 4778 1942598
#> 4779 1946252
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#> 4781 1946255
#> 4782 1946507
#> 4783 1946518
#> 4784 1946519
#> 4785 1948213
#> 4786 1948215
#> 4787 1948227
#> 4788 1948241
#> 4789 1948304
#> 4790 1948925
#> 4791 1949540
#> 4792 1949832
#> 4793 1949847
#> 4794 1949848
#> 4795 1949849
#> 4796 1949850
#> 4797 1949857
#> 4798 1949858
#> 4799 1949859
#> 4800 1949860
#> 4801 1949861
#> 4802 1949874
#> 4803 1949875
#> 4804 1949876
#> 4805 1949877
#> 4806 1949878
#> 4807 1949879
#> 4808 1951283
#> 4809 1951284
#> 4810 1951285
#> 4811 1951286
#> 4812 1951287
#> 4813 1951289
#> 4814 1951291
#> 4815 1951304
#> 4816 1951895
#> 4817 1951896
#> 4818 1951897
#> 4819 1951898
#> 4820 1951899
#> 4821 1951900
#> 4822 1951901
#> 4823 1952793
#> 4824 1953122
#> 4825 1953508
#> 4826 1953631
#> 4827 1954449
#> 4828 1954480
#> 4829 1954812
#> 4830 1954813
#> 4831 1955433
#> 4832 1955684
#> 4833 1955685
#> 4834 1955686
#> 4835 1955938
#> 4836 1956454
#> 4837 1956455
#> 4838 1956456
#> 4839 1956457
#> 4840 1956461
#> 4841 1956472
#> 4842 1958843
#> 4843 1959126
#> 4844 1959127
#> 4845 1959130
#> 4846 1959134
#> 4847 1959135
#> 4848 1959136
#> 4849 1959139
#> 4850 1959358
#> 4851 1960665
#> 4852 1960671
#> 4853 1960854
#> 4854 1961744
#> 4855 1962262
#> 4856 1962409
#> 4857 1962577
#> 4858 1963350
#> 4859 1963351
#> 4860 1963502Bioactivities from Protein: Returns concise bioactivity data for a specific protein. For example:
result <- get_pug_rest(identifier = "Q01279", namespace = "accession", domain = "protein", operation = "concise", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Protein
#> - Namespace: DomainSpecific
#> - Operation: concise
#> - Identifier: Q01279
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#> [1] "AID" "SID" "CID"
#> [4] "Activity Outcome" "Target GeneID" "Activity Value [uM]"
#> [7] "Activity Name" "Assay Name" "Assay Type"
#> [10] "PubMed ID"
#>
#>
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#> [1] "66438"
#> [2] "103250953"
#> [3] "25017867"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.01"
#> [7] "Effective concentration"
#> [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#> [9] "Confirmatory"
#> [10] "1597853"
#>
#>
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#> [1] "66438"
#> [2] "103432098"
#> [3] "454217"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.22"
#> [7] "Effective concentration"
#> [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#> [9] "Confirmatory"
#> [10] "1597853"
#>
#>
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#> [1] "69721"
#> [2] "103358917"
#> [3] "135512509"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "22.7"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#> [9] "Confirmatory"
#> [10] "9748366"
#>
#>
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#> [1] "69721"
#> [2] "103358918"
#> [3] "135434086"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "36.9"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#> [9] "Confirmatory"
#> [10] "9748366"
#>
#>
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#> [1] "69721"
#> [2] "103358919"
#> [3] "135455949"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "11.3"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#> [9] "Confirmatory"
#> [10] "9748366"
#>
#>
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#> [1] "69722"
#> [2] "103253186"
#> [3] "5328592"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#>
#>
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#> [1] "69722"
#> [2] "103253755"
#> [3] "5328614"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#>
#>
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#> [1] "69722"
#> [2] "103254313"
#> [3] "5328618"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#>
#>
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#> [1] "69722"
#> [2] "103254592"
#> [3] "5328617"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "25"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#> [9] "Confirmatory"
#> [10] "8027985"
#>
#>
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#> [1] "69724"
#> [2] "103237764"
#> [3] "5328042"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.04"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#>
#>
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#> [1] "69724"
#> [2] "103373305"
#> [3] "9882519"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.2"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#>
#>
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#> [1] "69724"
#> [2] "103373788"
#> [3] "9885081"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.07"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#>
#>
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#> [1] "69724"
#> [2] "103399645"
#> [3] "11198415"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.578"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#>
#>
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#> [1] "69724"
#> [2] "103399736"
#> [3] "10094127"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.13"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#>
#>
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#> [1] "69724"
#> [2] "103399893"
#> [3] "11349700"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.11"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#> [9] "Confirmatory"
#> [10] "14640561"
#>
#>
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#> [1] "69727"
#> [2] "103167027"
#> [3] "5280343"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#> [9] "Other"
#> [10] "8201603"
#>
#>
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#> [1] "69728"
#> [2] "103399857"
#> [3] "44368090"
#> [4] "Inactive"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK) (inactive)"
#> [9] "Other"
#> [10] "14640561"
#>
#>
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#> [1] "69729"
#> [2] "103167027"
#> [3] "5280343"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#> [9] "Other"
#> [10] "8201603"
#>
#>
#> $Table$Row[[19]]
#> $Table$Row[[19]]$Cell
#> [1] "69730"
#> [2] "103226434"
#> [3] "10318571"
#> [4] "Active"
#> [5] "13649"
#> [6] "4"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[20]]
#> $Table$Row[[20]]$Cell
#> [1] "69730"
#> [2] "103350640"
#> [3] "10406106"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "14"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[21]]
#> $Table$Row[[21]]$Cell
#> [1] "69730"
#> [2] "103378973"
#> [3] "10738302"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "33"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[22]]
#> $Table$Row[[22]]$Cell
#> [1] "69730"
#> [2] "103378974"
#> [3] "10761144"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "200"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[23]]
#> $Table$Row[[23]]$Cell
#> [1] "69730"
#> [2] "103379003"
#> [3] "10044189"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "500"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[24]]
#> $Table$Row[[24]]$Cell
#> [1] "69730"
#> [2] "103379199"
#> [3] "10428841"
#> [4] "Active"
#> [5] "13649"
#> [6] "8"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[25]]
#> $Table$Row[[25]]$Cell
#> [1] "69730"
#> [2] "103379200"
#> [3] "10716388"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[26]]
#> $Table$Row[[26]]$Cell
#> [1] "69730"
#> [2] "103379360"
#> [3] "10452792"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "50"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[27]]
#> $Table$Row[[27]]$Cell
#> [1] "69730"
#> [2] "103379591"
#> [3] "10620637"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "300"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[28]]
#> $Table$Row[[28]]$Cell
#> [1] "69730"
#> [2] "103379616"
#> [3] "10593843"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "100"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[29]]
#> $Table$Row[[29]]$Cell
#> [1] "69730"
#> [2] "103379617"
#> [3] "10787405"
#> [4] "Active"
#> [5] "13649"
#> [6] "4"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[30]]
#> $Table$Row[[30]]$Cell
#> [1] "69730"
#> [2] "103379660"
#> [3] "10343317"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "35"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[31]]
#> $Table$Row[[31]]$Cell
#> [1] "69730"
#> [2] "103379661"
#> [3] "10499929"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "15"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[32]]
#> $Table$Row[[32]]$Cell
#> [1] "69730"
#> [2] "103379682"
#> [3] "10500718"
#> [4] "Active"
#> [5] "13649"
#> [6] "1"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[33]]
#> $Table$Row[[33]]$Cell
#> [1] "69730"
#> [2] "103379908"
#> [3] "10619651"
#> [4] "Active"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[34]]
#> $Table$Row[[34]]$Cell
#> [1] "69730"
#> [2] "103379909"
#> [3] "10504027"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "35"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[35]]
#> $Table$Row[[35]]$Cell
#> [1] "69730"
#> [2] "103379910"
#> [3] "10740438"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "46"
#> [7] "IC50"
#> [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#> [9] "Confirmatory"
#> [10] "11462983"
#>
#>
#> $Table$Row[[36]]
#> $Table$Row[[36]]$Cell
#> [1] "106697"
#> [2] "103166113"
#> [3] "10499619"
#> [4] "Active"
#> [5] "13649"
#> [6] "9.55"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[37]]
#> $Table$Row[[37]]$Cell
#> [1] "106697"
#> [2] "103166157"
#> [3] "9978638"
#> [4] "Active"
#> [5] "13649"
#> [6] "4.93"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[38]]
#> $Table$Row[[38]]$Cell
#> [1] "106697"
#> [2] "103166217"
#> [3] "10590515"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "45.2"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[39]]
#> $Table$Row[[39]]$Cell
#> [1] "106697"
#> [2] "103166266"
#> [3] "10803234"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10.2"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[40]]
#> $Table$Row[[40]]$Cell
#> [1] "106697"
#> [2] "103166322"
#> [3] "2051"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.1"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[41]]
#> $Table$Row[[41]]$Cell
#> [1] "106697"
#> [2] "103166323"
#> [3] "10850934"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "16"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[42]]
#> $Table$Row[[42]]$Cell
#> [1] "106697"
#> [2] "103166405"
#> [3] "9883384"
#> [4] "Active"
#> [5] "13649"
#> [6] "2.83"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[43]]
#> $Table$Row[[43]]$Cell
#> [1] "106697"
#> [2] "103166415"
#> [3] "10494548"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "11.4"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[44]]
#> $Table$Row[[44]]$Cell
#> [1] "106697"
#> [2] "103166416"
#> [3] "689033"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "46.2"
#> [7] "IC50"
#> [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#> [9] "Confirmatory"
#> [10] "10090785"
#>
#>
#> $Table$Row[[45]]
#> $Table$Row[[45]]$Cell
#> [1] "209326"
#> [2] "103257455"
#> [3] "2428"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.046"
#> [7] "IC50"
#> [8] "Inhibition of EGF-mediated mitogenesis in Swiss 3T3 cells"
#> [9] "Confirmatory"
#> [10] "8632415"
#>
#>
#> $Table$Row[[46]]
#> $Table$Row[[46]]$Cell
#> [1] "241562"
#> [2] "103439646"
#> [3] "10209082"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[47]]
#> $Table$Row[[47]]$Cell
#> [1] "241562"
#> [2] "103439659"
#> [3] "10185160"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[48]]
#> $Table$Row[[48]]$Cell
#> [1] "241562"
#> [2] "103439663"
#> [3] "10143584"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[49]]
#> $Table$Row[[49]]$Cell
#> [1] "241562"
#> [2] "103439672"
#> [3] "10163439"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[50]]
#> $Table$Row[[50]]$Cell
#> [1] "241562"
#> [2] "103439700"
#> [3] "10302405"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[51]]
#> $Table$Row[[51]]$Cell
#> [1] "241562"
#> [2] "103439717"
#> [3] "10187378"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[52]]
#> $Table$Row[[52]]$Cell
#> [1] "241562"
#> [2] "123092436"
#> [3] "44259"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#> [9] "Confirmatory"
#> [10] "15771419"
#>
#>
#> $Table$Row[[53]]
#> $Table$Row[[53]]$Cell
#> [1] "241823"
#> [2] "103452251"
#> [3] "22732319"
#> [4] "Inconclusive"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of Epidermal growth factor receptor tyrosine kinase activity; not tested"
#> [9] "Other"
#> [10] "15454232"
#>
#>
#> $Table$Row[[54]]
#> $Table$Row[[54]]$Cell
#> [1] "337238"
#> [2] "103194285"
#> [3] "4075"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[55]]
#> $Table$Row[[55]]$Cell
#> [1] "337238"
#> [2] "103227545"
#> [3] "5328552"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[56]]
#> $Table$Row[[56]]$Cell
#> [1] "337238"
#> [2] "103319670"
#> [3] "3894"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[57]]
#> $Table$Row[[57]]$Cell
#> [1] "337238"
#> [2] "103319671"
#> [3] "3896"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[58]]
#> $Table$Row[[58]]$Cell
#> [1] "337238"
#> [2] "103529702"
#> [3] "65083"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[59]]
#> $Table$Row[[59]]$Cell
#> [1] "337238"
#> [2] "103529722"
#> [3] "70949"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[60]]
#> $Table$Row[[60]]$Cell
#> [1] "337238"
#> [2] "103618685"
#> [3] "3895"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[61]]
#> $Table$Row[[61]]$Cell
#> [1] "337238"
#> [2] "103618686"
#> [3] "44593598"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[62]]
#> $Table$Row[[62]]$Cell
#> [1] "337238"
#> [2] "103618687"
#> [3] "44593599"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[63]]
#> $Table$Row[[63]]$Cell
#> [1] "337238"
#> [2] "103618691"
#> [3] "375472"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[64]]
#> $Table$Row[[64]]$Cell
#> [1] "337238"
#> [2] "123092436"
#> [3] "44259"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[65]]
#> $Table$Row[[65]]$Cell
#> [1] "337243"
#> [2] "103319670"
#> [3] "3894"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR using [32P]gammaATP as substrate by competitive Lineweaver-Burke plot"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[66]]
#> $Table$Row[[66]]$Cell
#> [1] "337244"
#> [2] "103319670"
#> [3] "3894"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of mouse EGFR using tridecapeptide as substrate by uncompetitive Lineweaver-Burke plot"
#> [9] "Other"
#> [10] "2614420"
#>
#>
#> $Table$Row[[67]]
#> $Table$Row[[67]]$Cell
#> [1] "415757"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[68]]
#> $Table$Row[[68]]$Cell
#> [1] "415757"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[69]]
#> $Table$Row[[69]]$Cell
#> [1] "415758"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[70]]
#> $Table$Row[[70]]$Cell
#> [1] "415758"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[71]]
#> $Table$Row[[71]]$Cell
#> [1] "415759"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[72]]
#> $Table$Row[[72]]$Cell
#> [1] "415759"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[73]]
#> $Table$Row[[73]]$Cell
#> [1] "415760"
#> [2] "103294831"
#> [3] "5289418"
#> [4] "Inactive"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[74]]
#> $Table$Row[[74]]$Cell
#> [1] "415760"
#> [2] "103295395"
#> [3] "5941540"
#> [4] "Inactive"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#> [9] "Other"
#> [10] "9139660"
#>
#>
#> $Table$Row[[75]]
#> $Table$Row[[75]]$Cell
#> [1] "1527521"
#> [2] "312367127"
#> [3] "71496458"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.081"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[76]]
#> $Table$Row[[76]]$Cell
#> [1] "1527521"
#> [2] "440110169"
#> [3] "139593669"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[77]]
#> $Table$Row[[77]]$Cell
#> [1] "1527521"
#> [2] "440119817"
#> [3] "155517202"
#> [4] "Inconclusive"
#> [5] "13649"
#> [6] ""
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[78]]
#> $Table$Row[[78]]$Cell
#> [1] "1527521"
#> [2] "440125045"
#> [3] "139447864"
#> [4] "Active"
#> [5] "13649"
#> [6] "3.6"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[79]]
#> $Table$Row[[79]]$Cell
#> [1] "1527521"
#> [2] "440160302"
#> [3] "139593670"
#> [4] "Active"
#> [5] "13649"
#> [6] "1.3"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[80]]
#> $Table$Row[[80]]$Cell
#> [1] "1527521"
#> [2] "440163841"
#> [3] "139447649"
#> [4] "Active"
#> [5] "13649"
#> [6] "5.1"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[81]]
#> $Table$Row[[81]]$Cell
#> [1] "1527521"
#> [2] "440172005"
#> [3] "139447554"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.7"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[82]]
#> $Table$Row[[82]]$Cell
#> [1] "1527521"
#> [2] "440176009"
#> [3] "139600318"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.19"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[83]]
#> $Table$Row[[83]]$Cell
#> [1] "1527521"
#> [2] "440182946"
#> [3] "155444794"
#> [4] "Active"
#> [5] "13649"
#> [6] "2.3"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[84]]
#> $Table$Row[[84]]$Cell
#> [1] "1527521"
#> [2] "440203081"
#> [3] "155444797"
#> [4] "Active"
#> [5] "13649"
#> [6] "1.1"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[85]]
#> $Table$Row[[85]]$Cell
#> [1] "1527521"
#> [2] "440207922"
#> [3] "155444848"
#> [4] "Active"
#> [5] "13649"
#> [6] "0.27"
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[86]]
#> $Table$Row[[86]]$Cell
#> [1] "1527521"
#> [2] "440227038"
#> [3] "139593668"
#> [4] "Inconclusive"
#> [5] "13649"
#> [6] ""
#> [7] "IC50"
#> [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "31689114"
#>
#>
#> $Table$Row[[87]]
#> $Table$Row[[87]]$Cell
#> [1] "1740135"
#> [2] "312367127"
#> [3] "71496458"
#> [4] "Active"
#> [5] "13649"
#> [6] "2.6"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[88]]
#> $Table$Row[[88]]$Cell
#> [1] "1740135"
#> [2] "461515468"
#> [3] "162643657"
#> [4] "Inconclusive"
#> [5] "13649"
#> [6] ""
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[89]]
#> $Table$Row[[89]]$Cell
#> [1] "1740135"
#> [2] "461515649"
#> [3] "162643790"
#> [4] "Active"
#> [5] "13649"
#> [6] "9.23"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[90]]
#> $Table$Row[[90]]$Cell
#> [1] "1740135"
#> [2] "461542097"
#> [3] "162662364"
#> [4] "Active"
#> [5] "13649"
#> [6] "3.91"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[91]]
#> $Table$Row[[91]]$Cell
#> [1] "1740135"
#> [2] "461543217"
#> [3] "162663118"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[92]]
#> $Table$Row[[92]]$Cell
#> [1] "1740135"
#> [2] "461546315"
#> [3] "162665339"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[93]]
#> $Table$Row[[93]]$Cell
#> [1] "1740135"
#> [2] "461547480"
#> [3] "162666122"
#> [4] "Active"
#> [5] "13649"
#> [6] "4.27"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[94]]
#> $Table$Row[[94]]$Cell
#> [1] "1740135"
#> [2] "461549927"
#> [3] "162667840"
#> [4] "Active"
#> [5] "13649"
#> [6] "3.79"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[95]]
#> $Table$Row[[95]]$Cell
#> [1] "1740135"
#> [2] "461550238"
#> [3] "162668052"
#> [4] "Active"
#> [5] "13649"
#> [6] "2.65"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[96]]
#> $Table$Row[[96]]$Cell
#> [1] "1740135"
#> [2] "461550466"
#> [3] "162668204"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[97]]
#> $Table$Row[[97]]$Cell
#> [1] "1740135"
#> [2] "461555362"
#> [3] "162671649"
#> [4] "Inconclusive"
#> [5] "13649"
#> [6] ""
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[98]]
#> $Table$Row[[98]]$Cell
#> [1] "1740135"
#> [2] "461557317"
#> [3] "162673094"
#> [4] "Active"
#> [5] "13649"
#> [6] "9.23"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[99]]
#> $Table$Row[[99]]$Cell
#> [1] "1740135"
#> [2] "461557891"
#> [3] "162673491"
#> [4] "Active"
#> [5] "13649"
#> [6] "3.79"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[100]]
#> $Table$Row[[100]]$Cell
#> [1] "1740135"
#> [2] "461558880"
#> [3] "162674154"
#> [4] "Inconclusive"
#> [5] "13649"
#> [6] ""
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[101]]
#> $Table$Row[[101]]$Cell
#> [1] "1740135"
#> [2] "461562991"
#> [3] "162677073"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] "10"
#> [7] "GI50"
#> [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#> [9] "Confirmatory"
#> [10] "32619886"
#>
#>
#> $Table$Row[[102]]
#> $Table$Row[[102]]$Cell
#> [1] "1815786"
#> [2] "475982343"
#> [3] "166627448"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR 19Del/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#> [9] "Other"
#> [10] "35178175"
#>
#>
#> $Table$Row[[103]]
#> $Table$Row[[103]]$Cell
#> [1] "1815820"
#> [2] "475982343"
#> [3] "166627448"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR L858R/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#> [9] "Other"
#> [10] "35178175"
#>
#>
#> $Table$Row[[104]]
#> $Table$Row[[104]]$Cell
#> [1] "1862914"
#> [2] "482063640"
#> [3] "155431347"
#> [4] "Active"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Invivo inhibition of EGFR phosphorylation in nude mouse implanted with mouse BaF3 cells harboring EGFR del18/T790M/C797S triple mutant at 20 mg/kg, po administered as single dose and measured upto 24 hrs by Western blot analysis"
#> [9] "Other"
#> [10] "35810715"
#>
#>
#> $Table$Row[[105]]
#> $Table$Row[[105]]$Cell
#> [1] "1896806"
#> [2] "482061797"
#> [3] "166176964"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#> [9] "Other"
#> [10] "36384036"
#>
#>
#> $Table$Row[[106]]
#> $Table$Row[[106]]$Cell
#> [1] "1896806"
#> [2] "482062269"
#> [3] "168280117"
#> [4] "Unspecified"
#> [5] "13649"
#> [6] ""
#> [7] ""
#> [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#> [9] "Other"
#> [10] "36384036"Pathways from Protein: Provides a list of pathways involving a specific protein. For example, for protein accession P00533:
result <- get_pug_rest(identifier = "P00533", namespace = "accession", domain = "protein", operation = "pwaccs", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Protein
#> - Namespace: DomainSpecific
#> - Operation: pwaccs
#> - Identifier: P00533
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 PathBank:SMP0000472
#> 2 PathBank:SMP0000473
#> 3 PathBank:SMP0000474
#> 4 PathBank:SMP0000475
#> 5 PathBank:SMP0000476
#> 6 PathBank:SMP0063810
#> 7 PathBank:SMP0063811
#> 8 Pathway Interaction Database:a6b1_a6b4_integrin_pathway
#> 9 Pathway Interaction Database:ajdiss_2pathway
#> 10 Pathway Interaction Database:arf6_pathway
#> 11 Pathway Interaction Database:ecadherin_keratinocyte_pathway
#> 12 Pathway Interaction Database:ecadherin_stabilization_pathway
#> 13 Pathway Interaction Database:erbb1_downstream_pathway
#> 14 Pathway Interaction Database:erbb1_internalization_pathway
#> 15 Pathway Interaction Database:erbb_network_pathway
#> 16 Pathway Interaction Database:et_egfrpathway
#> 17 Pathway Interaction Database:lysophospholipid_pathway
#> 18 Pathway Interaction Database:p53downstreampathway
#> 19 Pathway Interaction Database:ptp1bpathway
#> 20 Pathway Interaction Database:shp2_pathway
#> 21 Pathway Interaction Database:syndecan_3_pathway
#> 22 Pathway Interaction Database:tcptp_pathway
#> 23 Pathway Interaction Database:telomerasepathway
#> 24 Pathway Interaction Database:txa2pathway
#> 25 Pathway Interaction Database:upa_upar_pathway
#> 26 PharmGKB:PA152325160
#> 27 PharmGKB:PA154426903
#> 28 PharmGKB:PA162356267
#> 29 PharmGKB:PA165980050
#> 30 Reactome:R-HSA-1227986
#> 31 Reactome:R-HSA-1227990
#> 32 Reactome:R-HSA-1236394
#> 33 Reactome:R-HSA-1266738
#> 34 Reactome:R-HSA-157118
#> 35 Reactome:R-HSA-162582
#> 36 Reactome:R-HSA-1643685
#> 37 Reactome:R-HSA-1643713
#> 38 Reactome:R-HSA-177929
#> 39 Reactome:R-HSA-179812
#> 40 Reactome:R-HSA-180292
#> 41 Reactome:R-HSA-180336
#> 42 Reactome:R-HSA-182971
#> 43 Reactome:R-HSA-199991
#> 44 Reactome:R-HSA-212436
#> 45 Reactome:R-HSA-212718
#> 46 Reactome:R-HSA-2179392
#> 47 Reactome:R-HSA-372790
#> 48 Reactome:R-HSA-373760
#> 49 Reactome:R-HSA-388396
#> 50 Reactome:R-HSA-416476
#> 51 Reactome:R-HSA-422475
#> 52 Reactome:R-HSA-445144
#> 53 Reactome:R-HSA-5637810
#> 54 Reactome:R-HSA-5637812
#> 55 Reactome:R-HSA-5638302
#> 56 Reactome:R-HSA-5638303
#> 57 Reactome:R-HSA-5653656
#> 58 Reactome:R-HSA-5663202
#> 59 Reactome:R-HSA-73857
#> 60 Reactome:R-HSA-74160
#> 61 Reactome:R-HSA-881907
#> 62 Reactome:R-HSA-8848021
#> 63 Reactome:R-HSA-8856825
#> 64 Reactome:R-HSA-8856828
#> 65 Reactome:R-HSA-8857538
#> 66 Reactome:R-HSA-8864260
#> 67 Reactome:R-HSA-8866910
#> 68 Reactome:R-HSA-8939211
#> 69 Reactome:R-HSA-9006927
#> 70 Reactome:R-HSA-9006931
#> 71 Reactome:R-HSA-9006934
#> 72 Reactome:R-HSA-9009391
#> 73 Reactome:R-HSA-9012852
#> 74 Reactome:R-HSA-9013507
#> 75 Reactome:R-HSA-9634638
#> 76 Reactome:R-HSA-9664565
#> 77 Reactome:R-HSA-9665348
#> 78 Reactome:R-HSA-9665686
#> 79 Reactome:R-HSA-9675108
#> 80 WikiPathways:WP1984
#> 81 WikiPathways:WP2643
#> 82 WikiPathways:WP2840
#> 83 WikiPathways:WP5144
#> 84 WikiPathways:WP5158
#> 85 WikiPathways:WP5322These methods offer a comprehensive approach to accessing and analyzing protein-related data in PubChem, supporting a wide range of research applications in the fields of biochemistry, molecular biology, and pharmacology.
PubChem’s PUG REST service offers a detailed and comprehensive approach to accessing pathway information, crucial for researchers in fields like bioinformatics, pharmacology, and molecular biology. Here’s how to utilize PUG REST for pathway-related queries:
1. Pathway Input Methods:
By Pathway Accession: The primary method to access pathway data in PubChem. Pathway Accession is formatted as Source:ID. For example, to get a summary for the Reactome pathway R-HSA-70171 in JSON format:
result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: DomainSpecific (pathway)
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: Reactome:R-HSA-70171
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $PathwaySummaries
#> $PathwaySummaries$PathwaySummary
#> $PathwaySummaries$PathwaySummary[[1]]
#> $PathwaySummaries$PathwaySummary[[1]]$PathwayAccession
#> [1] "Reactome:R-HSA-70171"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$SourceName
#> [1] "Reactome"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$SourceID
#> [1] "R-HSA-70171"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$SourceURL
#> [1] "https://reactome.org/content/detail/R-HSA-70171"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Name
#> [1] "Glycolysis"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Type
#> [1] "organism_specific"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Category
#> [1] "pathway"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Description
#> [1] "The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate."
#>
#> $PathwaySummaries$PathwaySummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"2. Available Pathway Data:
Pathway Summary: Returns a summary including PathwayAccession, SourceName, Name, Type, Category, Description, TaxonomyID, and Taxonomy. For example:
result <- get_pug_rest(identifier = "Reactome:R-HSA-70171,BioCyc:HUMAN_PWY-4983", namespace = "pwacc", domain = "pathway", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: DomainSpecific (pathway)
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: Reactome:R-HSA-70171,BioCyc:HUMAN_PWY-4983
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $PathwaySummaries
#> $PathwaySummaries$PathwaySummary
#> $PathwaySummaries$PathwaySummary[[1]]
#> $PathwaySummaries$PathwaySummary[[1]]$PathwayAccession
#> [1] "Reactome:R-HSA-70171"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$SourceName
#> [1] "Reactome"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$SourceID
#> [1] "R-HSA-70171"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$SourceURL
#> [1] "https://reactome.org/content/detail/R-HSA-70171"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Name
#> [1] "Glycolysis"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Type
#> [1] "organism_specific"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Category
#> [1] "pathway"
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Description
#> [1] "The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate."
#>
#> $PathwaySummaries$PathwaySummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $PathwaySummaries$PathwaySummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#>
#>
#> $PathwaySummaries$PathwaySummary[[2]]
#> $PathwaySummaries$PathwaySummary[[2]]$PathwayAccession
#> [1] "BioCyc:HUMAN_PWY-4983"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$SourceName
#> [1] "BioCyc"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$SourceID
#> [1] "PWY-4983"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$SourceURL
#> [1] "https://biocyc.org/pathway?orgid=HUMAN&id=PWY-4983"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$Name
#> [1] "citrulline-nitric oxide cycle"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$Type
#> [1] "organism_specific"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$Category
#> [1] "pathway"
#>
#> $PathwaySummaries$PathwaySummary[[2]]$Description
#> [1] "<b>General Background</b>\n\n|FRAME: NITRIC-OXIDE \"Nitric oxide\"| (NO) is the active moiety of the endothelium-derived relaxing factor. In the vasculature NO relaxes smooth muscle and inhibits platelet and leukocyte adhesion. Outside the vasculature, NO participates in the immunologic response to infection. It serves as a neurotransmitter and plays an important role in cell signaling in the nervous system, and in synaptic plasticity. \n\nNitric oxide synthases are a family of enzymes responsible for the NADPH dependent synthesis of nitric oxide from |FRAME: ARG| and oxygen in the |FRAME: PWY-4983|.\n\n<b>About this Pathway</b>\n\n|FRAME: NITRIC-OXIDE \"Nitric oxide\"| can be synthesized by three nitric oxide synthases from |FRAME: ARG| generating |FRAME:L-CITRULLINE| as a by-product. In this cycle, arginine forms NO and citrulline, and is subsequently regenerated from citrulline by the action of the enzymes |FRAME:CPLX-6641| and |FRAME:CPLX-6661|. These two enzymes are shared with the |FRAME: PWY-4984|. Citrulline is also required in |FRAME: PWY-4921|.\n\nThe citrulline-NO cycle functions in many different types of cells. It has been demonstrated in epithelial cells, chondrocytes, endothelial cells, macrophages and neurons |CITS: [2236071]||CITS:[1731766]|.\n\nThe enzymes |FRAME: CPLX-6641| and |FRAME: CPLX-6661| confer cells with the capacity to produce NO without the need for exogenous arginine. In vascular smooth muscle cells |FRAME: CPLX-6661| is constitutively expressed but |FRAME: CPLX-6641| is inducible by cytokines and bacterial endotoxin |CITS:[7511585]|."
#>
#> $PathwaySummaries$PathwaySummary[[2]]$TaxonomyID
#> [1] 9606
#>
#> $PathwaySummaries$PathwaySummary[[2]]$Taxonomy
#> [1] "Homo sapiens (human)"Compounds from Pathway: Retrieves a list of compounds involved in a specific pathway. For example, for the Reactome pathway R-HSA-70171:
result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "cids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: DomainSpecific (pathway)
#> - Namespace: DomainSpecific
#> - Operation: cids
#> - Identifier: Reactome:R-HSA-70171
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 223
#> 2 311
#> 3 753
#> 4 813
#> 5 888
#> 6 962
#> 7 1038
#> 8 65246
#> 9 79025
#> 10 82400
#> 11 105021
#> 12 107735
#> 13 152306
#> 14 439217
#> 15 3674425
#> 16 3681305
#> 17 4643300
#> 18 5460765
#> 19 5461108
#> 20 7058055
#> 21 7059571
#> 22 9548671
#> 23 15938965
#> 24 15938971
#> 25 21604863
#> 26 21604864
#> 27 21604869
#> 28 24794350
#> 29 25245548
#> 30 40467846
#> 31 45266541
#> 32 46878409Genes from Pathway: Provides a list of genes involved in a specific pathway. For example, for the Reactome pathway R-HSA-70171:
result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "geneids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: DomainSpecific (pathway)
#> - Namespace: DomainSpecific
#> - Operation: geneids
#> - Identifier: Reactome:R-HSA-70171
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 226
#> 2 229
#> 3 230
#> 4 669
#> 5 2023
#> 6 2026
#> 7 2027
#> 8 2597
#> 9 2645
#> 10 2646
#> 11 2821
#> 12 4927
#> 13 5207
#> 14 5208
#> 15 5209
#> 16 5210
#> 17 5211
#> 18 5213
#> 19 5214
#> 20 5223
#> 21 5224
#> 22 5230
#> 23 5232
#> 24 5528
#> 25 5903
#> 26 6396
#> 27 7167
#> 28 7175
#> 29 8021
#> 30 8086
#> 31 8480
#> 32 9631
#> 33 9688
#> 34 9972
#> 35 10007
#> 36 10762
#> 37 11097
#> 38 23165
#> 39 23225
#> 40 23279
#> 41 23511
#> 42 23636
#> 43 26330
#> 44 53371
#> 45 55706
#> 46 55746
#> 47 57122
#> 48 79023
#> 49 79902
#> 50 83440
#> 51 129401
#> 52 132789
#> 53 283209
#> 54 283871
#> 55 348995
#> 56 387712Proteins from Pathway: Returns a list of proteins involved in a given pathway. For example, for the Reactome pathway R-HSA-70171:
result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "accessions", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: DomainSpecific (pathway)
#> - Namespace: DomainSpecific
#> - Operation: accessions
#> - Identifier: Reactome:R-HSA-70171
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 A6NDG6
#> 2 A6NNW6
#> 3 O14556
#> 4 O15504
#> 5 O60825
#> 6 O75694
#> 7 P00558
#> 8 P04075
#> 9 P04406
#> 10 P05062
#> 11 P06733
#> 12 P06744
#> 13 P07205
#> 14 P07738
#> 15 P08237
#> 16 P09104
#> 17 P09972
#> 18 P12270
#> 19 P13929
#> 20 P14618-1
#> 21 P14618-2
#> 22 P15259
#> 23 P16118
#> 24 P17858
#> 25 P18669
#> 26 P35557
#> 27 P35658
#> 28 P37198
#> 29 P46926
#> 30 P49790
#> 31 P49792
#> 32 P52948-5
#> 33 P55735
#> 34 P57740
#> 35 P60174
#> 36 P78406
#> 37 Q01813
#> 38 Q12769
#> 39 Q14397
#> 40 Q14738
#> 41 Q16875
#> 42 Q16877
#> 43 Q5SRE5
#> 44 Q6PCE3
#> 45 Q7Z3B4
#> 46 Q8N1F7
#> 47 Q8NFH3
#> 48 Q8NFH4
#> 49 Q8NFH5
#> 50 Q8TDQ7
#> 51 Q8TEM1
#> 52 Q8WUM0
#> 53 Q92621
#> 54 Q96EE3-1
#> 55 Q96EE3-2
#> 56 Q99567
#> 57 Q9BRR6
#> 58 Q9BTX1
#> 59 Q9BW27
#> 60 Q9NRG9
#> 61 Q9UKX7These methods offer a streamlined and efficient way to access and analyze pathway-related data in PubChem, supporting a wide range of research applications in bioinformatics, molecular biology, and related fields.
PubChem’s PUG REST service provides a comprehensive approach to accessing taxonomy information, essential for researchers in fields like biology, pharmacology, and environmental science. Here’s how to utilize PUG REST for taxonomy-related queries:
1. Taxonomy Input Methods:
By Taxonomy ID: The primary method to access taxonomy data in PubChem using NCBI Taxonomy identifiers. For example, to get a summary for human (Taxonomy ID 9606) and SARS-CoV-2 (Taxonomy ID 2697049) in JSON format:
result <- get_pug_rest(identifier = "9606,2697049", namespace = "taxid", domain = "taxonomy", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Taxonomy
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: 9606,2697049
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $TaxonomySummaries
#> $TaxonomySummaries$TaxonomySummary
#> $TaxonomySummaries$TaxonomySummary[[1]]
#> $TaxonomySummaries$TaxonomySummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$ScientificName
#> [1] "Homo sapiens"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$CommonName
#> [1] "human"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$Rank
#> [1] "species"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$RankedLineage
#> Species Genus Family Order Class Phylum
#> "" "Homo" "Hominidae" "Primates" "Mammalia" "Chordata"
#> Kingdom Superkingdom
#> "Metazoa" "Eukaryota"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$Synonym
#> [1] "Homo sapiens Linnaeus, 1758" "Homo sapiens"
#> [3] "human"
#>
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]
#> $TaxonomySummaries$TaxonomySummary[[2]]$TaxonomyID
#> [1] 2697049
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$ScientificName
#> [1] "Severe acute respiratory syndrome coronavirus 2"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$CommonName
#> [1] ""
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$Rank
#> [1] "no rank"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$RankedLineage
#> Species
#> "Severe acute respiratory syndrome-related coronavirus"
#> Genus
#> "Betacoronavirus"
#> Family
#> "Coronaviridae"
#> Order
#> "Nidovirales"
#> Class
#> "Pisoniviricetes"
#> Phylum
#> "Pisuviricota"
#> Kingdom
#> "Orthornavirae"
#> Superkingdom
#> "Viruses"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$Synonym
#> [1] "2019-nCoV"
#> [2] "COVID-19 virus"
#> [3] "HCoV-19"
#> [4] "Human coronavirus 2019"
#> [5] "SARS-2"
#> [6] "SARS2"
#> [7] "SARS-CoV2"
#> [8] "Severe acute respiratory syndrome coronavirus 2"By Taxonomy Synonym: Access taxonomy data using synonyms like scientific or common names. For example, for Homo sapiens:
result <- get_pug_rest(identifier = "Homo sapiens", namespace = "synonym", domain = "taxonomy", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Taxonomy
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: Homo sapiens
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $TaxonomySummaries
#> $TaxonomySummaries$TaxonomySummary
#> $TaxonomySummaries$TaxonomySummary[[1]]
#> $TaxonomySummaries$TaxonomySummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$ScientificName
#> [1] "Homo sapiens"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$CommonName
#> [1] "human"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$Rank
#> [1] "species"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$RankedLineage
#> Species Genus Family Order Class Phylum
#> "" "Homo" "Hominidae" "Primates" "Mammalia" "Chordata"
#> Kingdom Superkingdom
#> "Metazoa" "Eukaryota"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$Synonym
#> [1] "Homo sapiens Linnaeus, 1758" "Homo sapiens"
#> [3] "human"2. Available Taxonomy Data:
Taxonomy Summary: Returns a summary including TaxonomyID, ScientificName, CommonName, Rank, RankedLineage, and Synonyms. For example:
result <- get_pug_rest(identifier = "9606,10090,10116", namespace = "taxid", domain = "taxonomy", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Taxonomy
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: 9606,10090,10116
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $TaxonomySummaries
#> $TaxonomySummaries$TaxonomySummary
#> $TaxonomySummaries$TaxonomySummary[[1]]
#> $TaxonomySummaries$TaxonomySummary[[1]]$TaxonomyID
#> [1] 9606
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$ScientificName
#> [1] "Homo sapiens"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$CommonName
#> [1] "human"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$Rank
#> [1] "species"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$RankedLineage
#> Species Genus Family Order Class Phylum
#> "" "Homo" "Hominidae" "Primates" "Mammalia" "Chordata"
#> Kingdom Superkingdom
#> "Metazoa" "Eukaryota"
#>
#> $TaxonomySummaries$TaxonomySummary[[1]]$Synonym
#> [1] "Homo sapiens Linnaeus, 1758" "Homo sapiens"
#> [3] "human"
#>
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]
#> $TaxonomySummaries$TaxonomySummary[[2]]$TaxonomyID
#> [1] 10090
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$ScientificName
#> [1] "Mus musculus"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$CommonName
#> [1] "house mouse"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$Rank
#> [1] "species"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$RankedLineage
#> Species Genus Family Order Class Phylum
#> "" "Mus" "Muridae" "Rodentia" "Mammalia" "Chordata"
#> Kingdom Superkingdom
#> "Metazoa" "Eukaryota"
#>
#> $TaxonomySummaries$TaxonomySummary[[2]]$Synonym
#> [1] "house mouse" "mouse"
#> [3] "Mus musculus Linnaeus, 1758" "Mus musculus"
#>
#>
#> $TaxonomySummaries$TaxonomySummary[[3]]
#> $TaxonomySummaries$TaxonomySummary[[3]]$TaxonomyID
#> [1] 10116
#>
#> $TaxonomySummaries$TaxonomySummary[[3]]$ScientificName
#> [1] "Rattus norvegicus"
#>
#> $TaxonomySummaries$TaxonomySummary[[3]]$CommonName
#> [1] "Norway rat"
#>
#> $TaxonomySummaries$TaxonomySummary[[3]]$Rank
#> [1] "species"
#>
#> $TaxonomySummaries$TaxonomySummary[[3]]$RankedLineage
#> Species Genus Family Order Class Phylum
#> "" "Rattus" "Muridae" "Rodentia" "Mammalia" "Chordata"
#> Kingdom Superkingdom
#> "Metazoa" "Eukaryota"
#>
#> $TaxonomySummaries$TaxonomySummary[[3]]$Synonym
#> [1] "brown rat" "Mus norvegicus Berkenhout, 1769"
#> [3] "Mus norvegicus" "Norway rat"
#> [5] "rat" "rats"
#> [7] "Rattus norvegicus"Assays and Bioactivities: Retrieves a list of assays (AIDs) associated with a given taxonomy. For example, for SARS-CoV-2:
result <- get_pug_rest(identifier = "2697049", namespace = "taxid", domain = "taxonomy", operation = "aids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Taxonomy
#> - Namespace: DomainSpecific
#> - Operation: aids
#> - Identifier: 2697049
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
#> 1 1409578
#> 2 1409579
#> 3 1409582
#> 4 1409585
#> 5 1409588
#> 6 1409589
#> 7 1409590
#> 8 1409594
#> 9 1409595
#> 10 1409598
#> 11 1409599
#> 12 1409602
#> 13 1409603
#> 14 1409605
#> 15 1409606
#> 16 1409607
#> 17 1409608
#> 18 1409614
#> 19 1409623
#> 20 1645758
#> 21 1645759
#> 22 1671498
#> 23 1671499
#> 24 1678482
#> 25 1682556
#> 26 1684795
#> 27 1684805
#> 28 1684808
#> 29 1684809
#> 30 1685583
#> 31 1692496
#> 32 1704258
#> 33 1717739
#> 34 1717742
#> 35 1717748
#> 36 1717755
#> 37 1717812
#> 38 1717813
#> 39 1733128
#> 40 1733183
#> 41 1750792
#> 42 1756674
#> 43 1756676
#> 44 1756677
#> 45 1756960
#> 46 1756961
#> 47 1756962
#> 48 1762039
#> 49 1762040
#> 50 1762041
#> 51 1762042
#> 52 1762043
#> 53 1762044
#> 54 1763053
#> 55 1763054
#> 56 1763571
#> 57 1763573
#> 58 1763925
#> 59 1766061
#> 60 1766062
#> 61 1766065
#> 62 1766066
#> 63 1766070
#> 64 1766122
#> 65 1766126
#> 66 1766127
#> 67 1766128
#> 68 1766129
#> 69 1766130
#> 70 1766166
#> 71 1766167
#> 72 1766168
#> 73 1767844
#> 74 1767845
#> 75 1768968
#> 76 1768969
#> 77 1774049
#> 78 1774051
#> 79 1774052
#> 80 1774053
#> 81 1774054
#> 82 1777358
#> 83 1777359
#> 84 1777360
#> 85 1777361
#> 86 1777362
#> 87 1778630
#> 88 1782697
#> 89 1783387
#> 90 1783391
#> 91 1783393
#> 92 1783396
#> 93 1783398
#> 94 1783399
#> 95 1783400
#> 96 1783420
#> 97 1783421
#> 98 1783422
#> 99 1785765
#> 100 1785767
#> 101 1785768
#> 102 1785769
#> 103 1785770
#> 104 1785771
#> 105 1785772
#> 106 1785773
#> 107 1785774
#> 108 1785775
#> 109 1785776
#> 110 1808127
#> 111 1809725
#> 112 1809727
#> 113 1809728
#> 114 1810094
#> 115 1810095
#> 116 1810096
#> 117 1810097
#> 118 1810098
#> 119 1810099
#> 120 1811315
#> 121 1811318
#> 122 1811334
#> 123 1811336
#> 124 1811337
#> 125 1812897
#> 126 1815250
#> 127 1815252
#> 128 1815257
#> 129 1815261
#> 130 1815328
#> 131 1815329
#> 132 1816643
#> 133 1816646
#> 134 1816648
#> 135 1816650
#> 136 1816677
#> 137 1816678
#> 138 1816679
#> 139 1816680
#> 140 1817679
#> 141 1817680
#> 142 1817681
#> 143 1817683
#> 144 1817714
#> 145 1817715
#> 146 1817716
#> 147 1818936
#> 148 1820302
#> 149 1820303
#> 150 1820306
#> 151 1820307
#> 152 1820344
#> 153 1820345
#> 154 1820346
#> 155 1820417
#> 156 1820419
#> 157 1820425
#> 158 1820426
#> 159 1820428
#> 160 1820429
#> 161 1820434
#> 162 1820437
#> 163 1820447
#> 164 1825216
#> 165 1825217
#> 166 1825218
#> 167 1825219
#> 168 1825220
#> 169 1832331
#> 170 1845235
#> 171 1845237
#> 172 1846469
#> 173 1846470
#> 174 1846471
#> 175 1846472
#> 176 1846473
#> 177 1846487
#> 178 1851895
#> 179 1851900
#> 180 1853884
#> 181 1853885
#> 182 1853886
#> 183 1853887
#> 184 1853888
#> 185 1853889
#> 186 1853890
#> 187 1853891
#> 188 1853892
#> 189 1853893
#> 190 1853894
#> 191 1853895
#> 192 1853896
#> 193 1853897
#> 194 1853898
#> 195 1853899
#> 196 1853900
#> 197 1854357
#> 198 1854360
#> 199 1854363
#> 200 1854437
#> 201 1856553
#> 202 1857250
#> 203 1857252
#> 204 1857253
#> 205 1857254
#> 206 1857255
#> 207 1857878
#> 208 1857879
#> 209 1857880
#> 210 1857881
#> 211 1857882
#> 212 1857884
#> 213 1857885
#> 214 1858559
#> 215 1858562
#> 216 1859992
#> 217 1859993
#> 218 1859994
#> 219 1859995
#> 220 1859998
#> 221 1860001
#> 222 1860002
#> 223 1860003
#> 224 1860004
#> 225 1860005
#> 226 1860006
#> 227 1860007
#> 228 1860008
#> 229 1860009
#> 230 1860012
#> 231 1860014
#> 232 1860015
#> 233 1860016
#> 234 1862231
#> 235 1862232
#> 236 1862233
#> 237 1862234
#> 238 1862235
#> 239 1863307
#> 240 1863308
#> 241 1863309
#> 242 1863314
#> 243 1863315
#> 244 1865408
#> 245 1865409
#> 246 1869094
#> 247 1869096
#> 248 1871176
#> 249 1871186
#> 250 1871187
#> 251 1871188
#> 252 1871195
#> 253 1871196
#> 254 1873612
#> 255 1875154
#> 256 1875161
#> 257 1875162
#> 258 1875163
#> 259 1875164
#> 260 1875166
#> 261 1875882
#> 262 1875889
#> 263 1875890
#> 264 1875896
#> 265 1875897
#> 266 1875908
#> 267 1875986
#> 268 1876053
#> 269 1876098
#> 270 1876253
#> 271 1876316
#> 272 1876321
#> 273 1876328
#> 274 1876330
#> 275 1876331
#> 276 1876332
#> 277 1877262
#> 278 1877267
#> 279 1877268
#> 280 1877269
#> 281 1877270
#> 282 1877271
#> 283 1877272
#> 284 1877273
#> 285 1877274
#> 286 1877275
#> 287 1877276
#> 288 1877277
#> 289 1878326
#> 290 1878327
#> 291 1878328
#> 292 1878329
#> 293 1878336
#> 294 1878337
#> 295 1878338
#> 296 1878353
#> 297 1878355
#> 298 1878356
#> 299 1879911
#> 300 1880205
#> 301 1880957
#> 302 1880958
#> 303 1881678
#> 304 1881681
#> 305 1881688
#> 306 1881695
#> 307 1881721
#> 308 1881729
#> 309 1881730
#> 310 1881733
#> 311 1881734
#> 312 1881735
#> 313 1881736
#> 314 1881737
#> 315 1881740
#> 316 1881741
#> 317 1881745
#> 318 1881747
#> 319 1882572
#> 320 1882573
#> 321 1882574
#> 322 1882575
#> 323 1884002
#> 324 1884004
#> 325 1884008
#> 326 1884010
#> 327 1884014
#> 328 1884019
#> 329 1884022
#> 330 1884029
#> 331 1884032
#> 332 1884044
#> 333 1884126
#> 334 1884127
#> 335 1884558
#> 336 1884560
#> 337 1884562
#> 338 1884564
#> 339 1884566
#> 340 1884568
#> 341 1884570
#> 342 1884572
#> 343 1888678
#> 344 1888679
#> 345 1888680
#> 346 1890667
#> 347 1890668
#> 348 1890669
#> 349 1890670
#> 350 1890671
#> 351 1890673
#> 352 1890674
#> 353 1890675
#> 354 1893718
#> 355 1893719
#> 356 1894685
#> 357 1895996
#> 358 1897958
#> 359 1897968
#> 360 1897970
#> 361 1897972
#> 362 1898047
#> 363 1898048
#> 364 1898049
#> 365 1898371
#> 366 1898372
#> 367 1898373
#> 368 1898386
#> 369 1898457
#> 370 1898461
#> 371 1898547
#> 372 1898748
#> 373 1898754
#> 374 1898765
#> 375 1898766
#> 376 1898773
#> 377 1898774
#> 378 1898775
#> 379 1898779
#> 380 1898782
#> 381 1898783
#> 382 1904972
#> 383 1906772
#> 384 1906784
#> 385 1906785
#> 386 1906786
#> 387 1906787
#> 388 1906788
#> 389 1906789
#> 390 1906802
#> 391 1906803
#> 392 1911673
#> 393 1911674
#> 394 1916354
#> 395 1916961
#> 396 1918729
#> 397 1918735
#> 398 1920272
#> 399 1920273
#> 400 1920276
#> 401 1922108
#> 402 1922110
#> 403 1922114
#> 404 1922118
#> 405 1922120
#> 406 1922122
#> 407 1922123
#> 408 1922125
#> 409 1922126
#> 410 1922131
#> 411 1922132
#> 412 1922133
#> 413 1922135
#> 414 1922136
#> 415 1922137
#> 416 1922139
#> 417 1922142
#> 418 1922144
#> 419 1922145
#> 420 1922147
#> 421 1922149
#> 422 1922999
#> 423 1923922
#> 424 1923923
#> 425 1923924
#> 426 1923931
#> 427 1923935
#> 428 1923952
#> 429 1926781
#> 430 1927265
#> 431 1927280
#> 432 1927286
#> 433 1928658
#> 434 1928660
#> 435 1928661
#> 436 1928667
#> 437 1928668
#> 438 1928669
#> 439 1928670
#> 440 1929028
#> 441 1929044
#> 442 1929691
#> 443 1929692
#> 444 1929693
#> 445 1931760
#> 446 1942232
#> 447 1942235
#> 448 1942239
#> 449 1942534
#> 450 1942540
#> 451 1942547
#> 452 1942556
#> 453 1942759
#> 454 1943742
#> 455 1943744
#> 456 1943746
#> 457 1943750
#> 458 1943779
#> 459 1943781
#> 460 1946884
#> 461 1946886
#> 462 1946932
#> 463 1946933
#> 464 1946937
#> 465 1946938
#> 466 1946939
#> 467 1948588
#> 468 1948591
#> 469 1951065
#> 470 1951067
#> 471 1951075
#> 472 1951104
#> 473 1951111
#> 474 1951112
#> 475 1951115
#> 476 1951510
#> 477 1951513
#> 478 1952452
#> 479 1952454
#> 480 1954264
#> 481 1954265
#> 482 1954267
#> 483 1955375
#> 484 1955377
#> 485 1955378
#> 486 1955380
#> 487 1955381
#> 488 1955384
#> 489 1955385
#> 490 1956257
#> 491 1956689
#> 492 1962013To aggregate concise bioactivity data from each AID:
result <- get_pug_rest(identifier = "1409578", namespace = "aid", domain = "assay", operation = "concise", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: concise
#> - Identifier: 1409578
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#> [1] "AID" "SID" "CID"
#> [4] "Activity Outcome" "Target Accession" "Target GeneID"
#> [7] "Activity Value [uM]" "Activity Name" "Assay Name"
#> [10] "Assay Type" "PubMed ID" "RNAi"
#>
#>
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#> [1] "1409578"
#> [2] "103196897"
#> [3] "11199915"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.22"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#> [1] "1409578"
#> [2] "103224052"
#> [3] "2247"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.1"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#> [1] "1409578"
#> [2] "103246927"
#> [3] "208917"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.1"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#> [1] "1409578"
#> [2] "103281094"
#> [3] "9801987"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.75"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#> [1] "1409578"
#> [2] "103368147"
#> [3] "6476696"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.25"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#> [1] "1409578"
#> [2] "103389209"
#> [3] "10316203"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.2"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#> [1] "1409578"
#> [2] "103439840"
#> [3] "73078"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.1"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#> [1] "1409578"
#> [2] "103467980"
#> [3] "11591924"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.2"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#> [1] "1409578"
#> [2] "103490076"
#> [3] "15984102"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.95"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#> [1] "1409578"
#> [2] "103626512"
#> [3] "44579921"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.6"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#> [1] "1409578"
#> [2] "381838043"
#> [3] "121304016"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.62"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#> [1] "1409578"
#> [2] "404718364"
#> [3] "10173277"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.023"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#> [1] "1409578"
#> [2] "405270384"
#> [3] "73715817"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.19"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#> [1] "1409578"
#> [2] "405270481"
#> [3] "3025960"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "1.2"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#> [1] "1409578"
#> [2] "405270549"
#> [3] "11527774"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.14"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#> [1] "1409578"
#> [2] "405270558"
#> [3] "70945511"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.3"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#> [1] "1409578"
#> [2] "405270636"
#> [3] "21476448"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.95"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""
#>
#>
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#> [1] "1409578"
#> [2] "405270669"
#> [3] "11582982"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.5"
#> [8] "EC50"
#> [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"
#> [11] ""
#> [12] ""These methods offer a streamlined and efficient way to access and analyze taxonomy-related data in PubChem, supporting a wide range of research applications in biology, pharmacology, environmental science, and related fields.
PubChem’s PUG REST service offers a valuable resource for accessing detailed information about various cell lines, crucial for research in cellular biology, pharmacology, and related fields. Here’s how to effectively use PUG REST for cell line-related queries:
1. Cell Line Input Methods:
By Cell Line Accession: Utilize Cellosaurus and ChEMBL cell line accessions for precise data retrieval. For example:
result <- get_pug_rest(identifier = "CHEMBL3308376,CVCL_0045", namespace = "cellacc", domain = "cell", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Cell
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: CHEMBL3308376,CVCL_0045
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $CellSummaries
#> $CellSummaries$CellSummary
#> $CellSummaries$CellSummary[[1]]
#> $CellSummaries$CellSummary[[1]]$CellAccession
#> [1] "CVCL_0030"
#>
#> $CellSummaries$CellSummary[[1]]$Name
#> [1] "HeLa"
#>
#> $CellSummaries$CellSummary[[1]]$Sex
#> [1] "Female"
#>
#> $CellSummaries$CellSummary[[1]]$Category
#> [1] "Cancer cell line"
#>
#> $CellSummaries$CellSummary[[1]]$SourceTissue
#> [1] "uterine cervix"
#>
#> $CellSummaries$CellSummary[[1]]$SourceTaxonomyID
#> [1] 9606
#>
#> $CellSummaries$CellSummary[[1]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#>
#> $CellSummaries$CellSummary[[1]]$Synonym
#> [1] "HELA" "Hela" "He La"
#> [4] "He-La" "HeLa-CCL2" "Henrietta Lacks cells"
#> [7] "Helacyton gartleri"
#>
#>
#> $CellSummaries$CellSummary[[2]]
#> $CellSummaries$CellSummary[[2]]$CellAccession
#> [1] "CVCL_0045"
#>
#> $CellSummaries$CellSummary[[2]]$Name
#> [1] "HEK293"
#>
#> $CellSummaries$CellSummary[[2]]$Sex
#> [1] "Female"
#>
#> $CellSummaries$CellSummary[[2]]$Category
#> [1] "Transformed cell line"
#>
#> $CellSummaries$CellSummary[[2]]$SourceTissue
#> [1] "kidney"
#>
#> $CellSummaries$CellSummary[[2]]$SourceTaxonomyID
#> [1] 9606
#>
#> $CellSummaries$CellSummary[[2]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#>
#> $CellSummaries$CellSummary[[2]]$Synonym
#> [1] "Hek293" "HEK-293"
#> [3] "HEK/293" "HEK 293"
#> [5] "HEK;293" "293"
#> [7] "293 HEK" "293 Ad5"
#> [9] "Graham 293" "Graham-293"
#> [11] "Human Embryonic Kidney 293"By Cell Line Synonym: Access data using cell line names or other synonyms. For instance, for the HeLa cell line:
result <- get_pug_rest(identifier = "HeLa", namespace = "synonym", domain = "cell", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Cell
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: HeLa
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $CellSummaries
#> $CellSummaries$CellSummary
#> $CellSummaries$CellSummary[[1]]
#> $CellSummaries$CellSummary[[1]]$CellAccession
#> [1] "CVCL_0030"
#>
#> $CellSummaries$CellSummary[[1]]$Name
#> [1] "HeLa"
#>
#> $CellSummaries$CellSummary[[1]]$Sex
#> [1] "Female"
#>
#> $CellSummaries$CellSummary[[1]]$Category
#> [1] "Cancer cell line"
#>
#> $CellSummaries$CellSummary[[1]]$SourceTissue
#> [1] "uterine cervix"
#>
#> $CellSummaries$CellSummary[[1]]$SourceTaxonomyID
#> [1] 9606
#>
#> $CellSummaries$CellSummary[[1]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#>
#> $CellSummaries$CellSummary[[1]]$Synonym
#> [1] "HELA" "Hela" "He La"
#> [4] "He-La" "HeLa-CCL2" "Henrietta Lacks cells"
#> [7] "Helacyton gartleri"2. Available Cell Line Data:
Cell Line Summary: Provides a comprehensive overview including CellAccession, Name, Sex, Category, SourceTissue, SourceTaxonomyID, SourceOrganism, and Synonyms. For example:
result <- get_pug_rest(identifier = "CVCL_0030,CVCL_0045", namespace = "cellacc", domain = "cell", operation = "summary", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Cell
#> - Namespace: DomainSpecific
#> - Operation: summary
#> - Identifier: CVCL_0030,CVCL_0045
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $CellSummaries
#> $CellSummaries$CellSummary
#> $CellSummaries$CellSummary[[1]]
#> $CellSummaries$CellSummary[[1]]$CellAccession
#> [1] "CVCL_0030"
#>
#> $CellSummaries$CellSummary[[1]]$Name
#> [1] "HeLa"
#>
#> $CellSummaries$CellSummary[[1]]$Sex
#> [1] "Female"
#>
#> $CellSummaries$CellSummary[[1]]$Category
#> [1] "Cancer cell line"
#>
#> $CellSummaries$CellSummary[[1]]$SourceTissue
#> [1] "uterine cervix"
#>
#> $CellSummaries$CellSummary[[1]]$SourceTaxonomyID
#> [1] 9606
#>
#> $CellSummaries$CellSummary[[1]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#>
#> $CellSummaries$CellSummary[[1]]$Synonym
#> [1] "HELA" "Hela" "He La"
#> [4] "He-La" "HeLa-CCL2" "Henrietta Lacks cells"
#> [7] "Helacyton gartleri"
#>
#>
#> $CellSummaries$CellSummary[[2]]
#> $CellSummaries$CellSummary[[2]]$CellAccession
#> [1] "CVCL_0045"
#>
#> $CellSummaries$CellSummary[[2]]$Name
#> [1] "HEK293"
#>
#> $CellSummaries$CellSummary[[2]]$Sex
#> [1] "Female"
#>
#> $CellSummaries$CellSummary[[2]]$Category
#> [1] "Transformed cell line"
#>
#> $CellSummaries$CellSummary[[2]]$SourceTissue
#> [1] "kidney"
#>
#> $CellSummaries$CellSummary[[2]]$SourceTaxonomyID
#> [1] 9606
#>
#> $CellSummaries$CellSummary[[2]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#>
#> $CellSummaries$CellSummary[[2]]$Synonym
#> [1] "Hek293" "HEK-293"
#> [3] "HEK/293" "HEK 293"
#> [5] "HEK;293" "293"
#> [7] "293 HEK" "293 Ad5"
#> [9] "Graham 293" "Graham-293"
#> [11] "Human Embryonic Kidney 293"Assays and Bioactivities from Cell Line: Retrieves a list of assays (AIDs) tested on a specific cell line. For example, for HeLa:
result <- get_pug_rest(identifier = "HeLa", namespace = "synonym", domain = "cell", operation = "aids", output = "TXT")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Cell
#> - Namespace: DomainSpecific
#> - Operation: aids
#> - Identifier: HeLa
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> Text
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#> 736 88224
#> 737 88256
#> 738 88295
#> 739 88302
#> 740 88342
#> 741 88343
#> 742 88344
#> 743 88345
#> 744 88347
#> 745 88348
#> 746 88349
#> 747 88350
#> 748 88351
#> 749 88352
#> 750 88353
#> 751 88354
#> 752 88355
#> 753 88356
#> 754 88357
#> 755 88358
#> 756 88359
#> 757 88360
#> 758 88361
#> 759 88362
#> 760 88363
#> 761 88364
#> 762 88365
#> 763 88366
#> 764 88367
#> 765 88368
#> 766 88369
#> 767 88370
#> 768 88371
#> 769 88372
#> 770 88373
#> 771 88374
#> 772 88375
#> 773 88376
#> 774 88377
#> 775 88378
#> 776 88379
#> 777 88380
#> 778 88381
#> 779 88382
#> 780 88383
#> 781 88384
#> 782 88385
#> 783 88386
#> 784 88387
#> 785 88502
#> 786 88503
#> 787 88504
#> 788 88505
#> 789 88506
#> 790 88507
#> 791 88508
#> 792 88509
#> 793 88510
#> 794 88511
#> 795 88512
#> 796 88513
#> 797 88514
#> 798 88515
#> 799 88516
#> 800 88517
#> 801 88518
#> 802 88519
#> 803 88520
#> 804 88521
#> 805 88522
#> 806 88523
#> 807 88524
#> 808 88525
#> 809 88526
#> 810 88527
#> 811 88528
#> 812 88529
#> 813 88530
#> 814 88531
#> 815 88532
#> 816 88533
#> 817 88534
#> 818 88535
#> 819 88536
#> 820 88537
#> 821 88538
#> 822 88539
#> 823 88540
#> 824 88541
#> 825 88542
#> 826 88543
#> 827 88544
#> 828 88545
#> 829 88546
#> 830 88666
#> 831 88667
#> 832 88668
#> 833 88669
#> 834 88670
#> 835 88671
#> 836 88672
#> 837 88673
#> 838 88674
#> 839 88675
#> 840 88676
#> 841 88677
#> 842 88678
#> 843 88679
#> 844 88680
#> 845 88681
#> 846 88682
#> 847 88683
#> 848 88684
#> 849 88685
#> 850 88686
#> 851 88687
#> 852 88688
#> 853 88689
#> 854 88690
#> 855 88691
#> 856 88692
#> 857 88693
#> 858 88694
#> 859 88695
#> 860 88696
#> 861 88697
#> 862 88698
#> 863 88699
#> 864 88700
#> 865 88701
#> 866 88702
#> 867 88703
#> 868 88704
#> 869 88705
#> 870 88706
#> 871 88707
#> 872 88708
#> 873 88709
#> 874 88710
#> 875 88711
#> 876 88712
#> 877 88713
#> 878 88955
#> 879 90356
#> 880 90528
#> 881 91701
#> 882 91702
#> 883 93660
#> 884 102398
#> 885 102399
#> 886 102400
#> 887 102401
#> 888 102402
#> 889 103160
#> 890 103161
#> 891 103162
#> 892 103163
#> 893 103164
#> 894 103165
#> 895 103166
#> 896 103167
#> 897 103168
#> 898 103169
#> 899 103170
#> 900 103171
#> 901 103172
#> 902 103173
#> 903 103174
#> 904 103175
#> 905 103176
#> 906 103177
#> 907 103178
#> 908 103179
#> 909 103311
#> 910 103312
#> 911 103313
#> 912 103314
#> 913 103315
#> 914 103316
#> 915 103318
#> 916 103319
#> 917 103320
#> 918 103321
#> 919 103322
#> 920 103323
#> 921 103324
#> 922 103325
#> 923 103326
#> 924 103327
#> 925 103328
#> 926 103329
#> 927 103330
#> 928 103331
#> 929 103332
#> 930 103333
#> 931 103334
#> 932 103335
#> 933 103336
#> 934 103337
#> 935 103338
#> 936 103339
#> 937 103340
#> 938 103341
#> 939 103342
#> 940 103343
#> 941 106501
#> 942 148873
#> 943 148874
#> 944 148875
#> 945 156711
#> 946 156712
#> 947 156715
#> 948 162232
#> 949 162250
#> 950 162252
#> 951 162253
#> 952 164825
#> 953 167231
#> 954 198215
#> 955 198728
#> 956 199699
#> 957 199700
#> 958 199701
#> 959 199702
#> 960 199703
#> 961 199704
#> 962 199705
#> 963 199706
#> 964 199707
#> 965 199708
#> 966 199709
#> 967 199710
#> 968 199899
#> 969 199900
#> 970 199901
#> 971 199902
#> 972 200014
#> 973 200130
#> 974 200922
#> 975 200923
#> 976 200924
#> 977 210711
#> 978 210714
#> 979 210720
#> 980 210721
#> 981 211288
#> 982 211289
#> 983 211290
#> 984 211291
#> 985 211292
#> 986 211293
#> 987 211500
#> 988 211653
#> 989 211658
#> 990 211659
#> 991 211660
#> 992 211661
#> 993 212296
#> 994 212327
#> 995 212762
#> 996 212764
#> 997 216384
#> 998 216393
#> 999 216407
#> 1000 216534
#> 1001 216537
#> 1002 216544
#> 1003 217366
#> 1004 217367
#> 1005 217372
#> 1006 217380
#> 1007 217381
#> 1008 217382
#> 1009 217521
#> 1010 217530
#> 1011 217531
#> 1012 217984
#> 1013 217990
#> 1014 218003
#> 1015 220034
#> 1016 220035
#> 1017 220036
#> 1018 221145
#> 1019 221146
#> 1020 221626
#> 1021 221627
#> 1022 221813
#> 1023 222132
#> 1024 225768
#> 1025 225769
#> 1026 227069
#> 1027 228058
#> 1028 228059
#> 1029 228429
#> 1030 228576
#> 1031 228577
#> 1032 228578
#> 1033 229227
#> 1034 229228
#> 1035 229229
#> 1036 229230
#> 1037 229234
#> 1038 239013
#> 1039 239088
#> 1040 239093
#> 1041 239094
#> 1042 239185
#> 1043 239276
#> 1044 239346
#> 1045 239580
#> 1046 239954
#> 1047 240505
#> 1048 241010
#> 1049 241331
#> 1050 241691
#> 1051 242043
#> 1052 242068
#> 1053 242342
#> 1054 242363
#> 1055 242368
#> 1056 242378
#> 1057 242599
#> 1058 242629
#> 1059 242687
#> 1060 242704
#> 1061 242722
#> 1062 242790
#> 1063 242793
#> 1064 242817
#> 1065 242818
#> 1066 242827
#> 1067 242832
#> 1068 243130
#> 1069 243132
#> 1070 243383
#> 1071 243441
#> 1072 243474
#> 1073 243825
#> 1074 243913
#> 1075 243951
#> 1076 244674
#> 1077 244676
#> 1078 244716
#> 1079 244717
#> 1080 244765
#> 1081 244821
#> 1082 244859
#> 1083 244865
#> 1084 245935
#> 1085 246030
#> 1086 246036
#> 1087 246254
#> 1088 246262
#> 1089 246385
#> 1090 246457
#> 1091 247123
#> 1092 247473
#> 1093 247474
#> 1094 247559
#> 1095 247578
#> 1096 247584
#> 1097 247605
#> 1098 247662
#> 1099 247689
#> 1100 247734
#> 1101 247753
#> 1102 247772
#> 1103 247797
#> 1104 247881
#> 1105 247882
#> 1106 247922
#> 1107 247933
#> 1108 247998
#> 1109 248093
#> 1110 248144
#> 1111 248148
#> 1112 248242
#> 1113 248243
#> 1114 248269
#> 1115 248326
#> 1116 248475
#> 1117 248527
#> 1118 248537
#> 1119 248676
#> 1120 248684
#> 1121 248786
#> 1122 248799
#> 1123 248841
#> 1124 248842
#> 1125 248843
#> 1126 248844
#> 1127 248845
#> 1128 248846
#> 1129 248878
#> 1130 248879
#> 1131 248880
#> 1132 248881
#> 1133 248882
#> 1134 248913
#> 1135 249084
#> 1136 249085
#> 1137 249178
#> 1138 249261
#> 1139 249265
#> 1140 249268
#> 1141 249452
#> 1142 251317
#> 1143 251319
#> 1144 251734
#> 1145 251738
#> 1146 251739
#> 1147 251740
#> 1148 251741
#> 1149 252139
#> 1150 252375
#> 1151 252386
#> 1152 252584
#> 1153 252626
#> 1154 252954
#> 1155 253291
#> 1156 253292
#> 1157 254401
#> 1158 254583
#> 1159 254607
#> 1160 254646
#> 1161 255345
#> 1162 255346
#> 1163 255347
#> 1164 255652
#> 1165 255749
#> 1166 255816
#> 1167 255866
#> 1168 255874
#> 1169 255896
#> 1170 256016
#> 1171 256284
#> 1172 256285
#> 1173 256287
#> 1174 256292
#> 1175 256297
#> 1176 256298
#> 1177 256333
#> 1178 256334
#> 1179 256746
#> 1180 257360
#> 1181 257364
#> 1182 257888
#> 1183 257899
#> 1184 257900
#> 1185 257901
#> 1186 257931
#> 1187 257932
#> 1188 258074
#> 1189 258765
#> 1190 258766
#> 1191 259358
#> 1192 259362
#> 1193 259366
#> 1194 259369
#> 1195 259514
#> 1196 259518
#> 1197 260365
#> 1198 260417
#> 1199 260418
#> 1200 260523
#> 1201 260524
#> 1202 260660
#> 1203 260969
#> 1204 261532
#> 1205 261725
#> 1206 261726
#> 1207 261727
#> 1208 262010
#> 1209 262126
#> 1210 262202
#> 1211 262687
#> 1212 262825
#> 1213 262844
#> 1214 262953
#> 1215 262954
#> 1216 262955
#> 1217 262956
#> 1218 262957
#> 1219 263796
#> 1220 263797
#> 1221 263798
#> 1222 263930
#> 1223 264027
#> 1224 264033
#> 1225 264053
#> 1226 264148
#> 1227 264209
#> 1228 264268
#> 1229 264269
#> 1230 264270
#> 1231 264271
#> 1232 264272
#> 1233 264273
#> 1234 264274
#> 1235 264275
#> 1236 264276
#> 1237 264277
#> 1238 264278
#> 1239 264279
#> 1240 264280
#> 1241 264281
#> 1242 264282
#> 1243 264283
#> 1244 264284
#> 1245 264285
#> 1246 264286
#> 1247 264287
#> 1248 264288
#> 1249 264289
#> 1250 264290
#> 1251 264291
#> 1252 264292
#> 1253 264293
#> 1254 264294
#> 1255 264295
#> 1256 264296
#> 1257 264297
#> 1258 264298
#> 1259 264299
#> 1260 264300
#> 1261 264301
#> 1262 264302
#> 1263 264303
#> 1264 264529
#> 1265 264530
#> 1266 264533
#> 1267 264534
#> 1268 264982
#> 1269 265379
#> 1270 265388
#> 1271 265389
#> 1272 265390
#> 1273 267601
#> 1274 267602
#> 1275 267710
#> 1276 268212
#> 1277 268535
#> 1278 268704
#> 1279 269034
#> 1280 269488
#> 1281 269635
#> 1282 269636
#> 1283 269637
#> 1284 269638
#> 1285 269639
#> 1286 269668
#> 1287 270162
#> 1288 270163
#> 1289 270213
#> 1290 270399
#> 1291 270445
#> 1292 270446
#> 1293 270657
#> 1294 270822
#> 1295 270900
#> 1296 271075
#> 1297 271182
#> 1298 271188
#> 1299 271189
#> 1300 271413
#> 1301 271414
#> 1302 271415
#> 1303 271416
#> 1304 272290
#> 1305 272308
#> 1306 272769
#> 1307 273211
#> 1308 273212
#> 1309 273213
#> 1310 273253
#> 1311 273255
#> 1312 274079
#> 1313 274081
#> 1314 274117
#> 1315 274148
#> 1316 274997
#> 1317 274998
#> 1318 275003
#> 1319 275007
#> 1320 275010
#> 1321 275013
#> 1322 275015
#> 1323 275017
#> 1324 275071
#> 1325 275072
#> 1326 275088
#> 1327 275867
#> 1328 275868
#> 1329 275869
#> 1330 275870
#> 1331 275925
#> 1332 276006
#> 1333 276697
#> 1334 276700
#> 1335 276701
#> 1336 276702
#> 1337 276855
#> 1338 276856
#> 1339 276950
#> 1340 276951
#> 1341 276952
#> 1342 276953
#> 1343 276954
#> 1344 276955
#> 1345 277280
#> 1346 277832
#> 1347 277976
#> 1348 277977
#> 1349 278417
#> 1350 278860
#> 1351 278861
#> 1352 278867
#> 1353 278869
#> 1354 279326
#> 1355 280071
#> 1356 280079
#> 1357 280193
#> 1358 280194
#> 1359 280196
#> 1360 280204
#> 1361 280246
#> 1362 281111
#> 1363 281112
#> 1364 281113
#> 1365 281114
#> 1366 281115
#> 1367 281240
#> 1368 281241
#> 1369 281242
#> 1370 281337
#> 1371 281338
#> 1372 281340
#> 1373 281341
#> 1374 282003
#> 1375 282769
#> 1376 283987
#> 1377 284030
#> 1378 284040
#> 1379 284041
#> 1380 284207
#> 1381 284208
#> 1382 284287
#> 1383 284289
#> 1384 284519
#> 1385 284540
#> 1386 286454
#> 1387 286623
#> 1388 287274
#> 1389 287837
#> 1390 288359
#> 1391 288360
#> 1392 288364
#> 1393 288365
#> 1394 288446
#> 1395 288671
#> 1396 288672
#> 1397 288673
#> 1398 288674
#> 1399 288675
#> 1400 288676
#> 1401 288677
#> 1402 288678
#> 1403 288679
#> 1404 288680
#> 1405 288681
#> 1406 288682
#> 1407 288738
#> 1408 288840
#> 1409 288846
#> 1410 288929
#> 1411 288930
#> 1412 288931
#> 1413 288941
#> 1414 288942
#> 1415 288943
#> 1416 289013
#> 1417 289060
#> 1418 289176
#> 1419 289177
#> 1420 289178
#> 1421 289179
#> 1422 289259
#> 1423 289264
#> 1424 289789
#> 1425 290469
#> 1426 290474
#> 1427 291037
#> 1428 291039
#> 1429 291076
#> 1430 291746
#> 1431 291829
#> 1432 292436
#> 1433 292437
#> 1434 292438
#> 1435 292439
#> 1436 292440
#> 1437 292441
#> 1438 292442
#> 1439 292443
#> 1440 292444
#> 1441 292445
#> 1442 292448
#> 1443 292454
#> 1444 292675
#> 1445 292676
#> 1446 292677
#> 1447 292678
#> 1448 292679
#> 1449 292937
#> 1450 293059
#> 1451 293249
#> 1452 294074
#> 1453 294244
#> 1454 294517
#> 1455 294531
#> 1456 294826
#> 1457 294827
#> 1458 294838
#> 1459 295408
#> 1460 295409
#> 1461 295410
#> 1462 295755
#> 1463 295757
#> 1464 296517
#> 1465 296522
#> 1466 296523
#> 1467 296940
#> 1468 297005
#> 1469 297237
#> 1470 297238
#> 1471 297239
#> 1472 297312
#> 1473 297317
#> 1474 297325
#> 1475 297470
#> 1476 297471
#> 1477 297472
#> 1478 297473
#> 1479 298655
#> 1480 298659
#> 1481 298661
#> 1482 298739
#> 1483 298796
#> 1484 299281
#> 1485 299422
#> 1486 299461
#> 1487 299462
#> 1488 299526
#> 1489 299527
#> 1490 299709
#> 1491 300008
#> 1492 300369
#> 1493 300456
#> 1494 300457
#> 1495 300458
#> 1496 300459
#> 1497 300460
#> 1498 300461
#> 1499 300489
#> 1500 300690
#> 1501 300691
#> 1502 300692
#> 1503 300701
#> 1504 300832
#> 1505 301139
#> 1506 301211
#> 1507 301366
#> 1508 301367
#> 1509 301525
#> 1510 302013
#> 1511 302385
#> 1512 302817
#> 1513 302855
#> 1514 302866
#> 1515 302871
#> 1516 302872
#> 1517 302873
#> 1518 302874
#> 1519 302875
#> 1520 302876
#> 1521 302877
#> 1522 302878
#> 1523 302879
#> 1524 302880
#> 1525 302881
#> 1526 302882
#> 1527 303094
#> 1528 303095
#> 1529 303096
#> 1530 303229
#> 1531 303230
#> 1532 303232
#> 1533 303237
#> 1534 304536
#> 1535 304537
#> 1536 304538
#> 1537 305458
#> 1538 305572
#> 1539 305809
#> 1540 305850
#> 1541 306006
#> 1542 306007
#> 1543 306008
#> 1544 306009
#> 1545 306014
#> 1546 306016
#> 1547 306017
#> 1548 306018
#> 1549 306019
#> 1550 306020
#> 1551 306021
#> 1552 306022
#> 1553 306023
#> 1554 306024
#> 1555 306025
#> 1556 306830
#> 1557 306831
#> 1558 307321
#> 1559 307424
#> 1560 307643
#> 1561 308244
#> 1562 308319
#> 1563 308522
#> 1564 309182
#> 1565 309183
#> 1566 309356
#> 1567 309377
#> 1568 309396
#> 1569 309397
#> 1570 309598
#> 1571 309637
#> 1572 309667
#> 1573 310065
#> 1574 310123
#> 1575 310124
#> 1576 310180
#> 1577 310228
#> 1578 310363
#> 1579 311261
#> 1580 311262
#> 1581 311331
#> 1582 311336
#> 1583 311521
#> 1584 311630
#> 1585 311766
#> 1586 311999
#> 1587 312073
#> 1588 312074
#> 1589 312195
#> 1590 312196
#> 1591 312197
#> 1592 312198
#> 1593 312199
#> 1594 312200
#> 1595 312201
#> 1596 312202
#> 1597 312203
#> 1598 312204
#> 1599 312205
#> 1600 312206
#> 1601 312207
#> 1602 312208
#> 1603 312209
#> 1604 312210
#> 1605 312211
#> 1606 312212
#> 1607 312213
#> 1608 312214
#> 1609 312215
#> 1610 312216
#> 1611 312217
#> 1612 312218
#> 1613 312370
#> 1614 312939
#> 1615 312946
#> 1616 313206
#> 1617 313207
#> 1618 313208
#> 1619 313664
#> 1620 314058
#> 1621 314063
#> 1622 315517
#> 1623 315518
#> 1624 315519
#> 1625 315520
#> 1626 315521
#> 1627 315546
#> 1628 315561
#> 1629 315569
#> 1630 316764
#> 1631 316850
#> 1632 316851
#> 1633 316852
#> 1634 316853
#> 1635 316854
#> 1636 316855
#> 1637 316858
#> 1638 316859
#> 1639 316875
#> 1640 316884
#> 1641 316928
#> 1642 316942
#> 1643 317174
#> 1644 317178
#> 1645 317478
#> 1646 317535
#> 1647 317536
#> 1648 317537
#> 1649 317538
#> 1650 317539
#> 1651 317540
#> 1652 317541
#> 1653 317542
#> 1654 317814
#> 1655 317815
#> 1656 317816
#> 1657 318363
#> 1658 318588
#> 1659 318597
#> 1660 318733
#> 1661 318736
#> 1662 319509
#> 1663 319510
#> 1664 319511
#> 1665 319519
#> 1666 319520
#> 1667 320267
#> 1668 320287
#> 1669 320288
#> 1670 320294
#> 1671 320371
#> 1672 320372
#> 1673 320373
#> 1674 320374
#> 1675 320375
#> 1676 320376
#> 1677 320445
#> 1678 320446
#> 1679 320447
#> 1680 320448
#> 1681 320449
#> 1682 320450
#> 1683 320451
#> 1684 320452
#> 1685 320453
#> 1686 320454
#> 1687 320455
#> 1688 320456
#> 1689 320457
#> 1690 320458
#> 1691 320459
#> 1692 320460
#> 1693 320461
#> 1694 320462
#> 1695 320463
#> 1696 320464
#> 1697 320465
#> 1698 320466
#> 1699 320467
#> 1700 320468
#> 1701 320469
#> 1702 320473
#> 1703 320475
#> 1704 320476
#> 1705 320477
#> 1706 320478
#> 1707 320479
#> 1708 320480
#> 1709 321366
#> 1710 321367
#> 1711 321368
#> 1712 321369
#> 1713 321370
#> 1714 321371
#> 1715 321372
#> 1716 321373
#> 1717 321374
#> 1718 321824
#> 1719 321838
#> 1720 322145
#> 1721 322405
#> 1722 322485
#> 1723 322913
#> 1724 322919
#> 1725 322920
#> 1726 322921
#> 1727 322922
#> 1728 322923
#> 1729 322924
#> 1730 322925
#> 1731 322926
#> 1732 322927
#> 1733 322928
#> 1734 322929
#> 1735 322930
#> 1736 323178
#> 1737 323179
#> 1738 323587
#> 1739 323589
#> 1740 323591
#> 1741 323593
#> 1742 323638
#> 1743 323641
#> 1744 323642
#> 1745 323646
#> 1746 323647
#> 1747 323648
#> 1748 323649
#> 1749 323650
#> 1750 323651
#> 1751 323652
#> 1752 323653
#> 1753 323654
#> 1754 323655
#> 1755 323656
#> 1756 323657
#> 1757 323658
#> 1758 323997
#> 1759 324001
#> 1760 324905
#> 1761 325553
#> 1762 325581
#> 1763 326173
#> 1764 326910
#> 1765 327127
#> 1766 327269
#> 1767 327271
#> 1768 327273
#> 1769 327329
#> 1770 327335
#> 1771 327367
#> 1772 327541
#> 1773 327542
#> 1774 327543
#> 1775 327652
#> 1776 327673
#> 1777 327963
#> 1778 327964
#> 1779 327970
#> 1780 328805
#> 1781 328885
#> 1782 329144
#> 1783 329145
#> 1784 329146
#> 1785 329148
#> 1786 329150
#> 1787 329152
#> 1788 329296
#> 1789 329355
#> 1790 329356
#> 1791 329357
#> 1792 329435
#> 1793 329436
#> 1794 329437
#> 1795 329438
#> 1796 329439
#> 1797 329440
#> 1798 329445
#> 1799 329726
#> 1800 329802
#> 1801 329957
#> 1802 329961
#> 1803 329962
#> 1804 330649
#> 1805 331133
#> 1806 331618
#> 1807 332247
#> 1808 332251
#> 1809 332392
#> 1810 332393
#> 1811 332394
#> 1812 332395
#> 1813 332519
#> 1814 332520
#> 1815 332521
#> 1816 332657
#> 1817 333345
#> 1818 333399
#> 1819 333433
#> 1820 333437
#> 1821 333502
#> 1822 333698
#> 1823 333743
#> 1824 333817
#> 1825 333818
#> 1826 334172
#> 1827 334176
#> 1828 334215
#> 1829 334216
#> 1830 334217
#> 1831 334218
#> 1832 334278
#> 1833 334763
#> 1834 334920
#> 1835 334930
#> 1836 334932
#> 1837 334982
#> 1838 334983
#> 1839 334984
#> 1840 335543
#> 1841 335640
#> 1842 335672
#> 1843 335955
#> 1844 335957
#> 1845 335964
#> 1846 335965
#> 1847 335966
#> 1848 335967
#> 1849 335968
#> 1850 337076
#> 1851 337102
#> 1852 338805
#> 1853 338960
#> 1854 338970
#> 1855 339796
#> 1856 339797
#> 1857 339800
#> 1858 339801
#> 1859 339802
#> 1860 339996
#> 1861 340023
#> 1862 340025
#> 1863 340026
#> 1864 340661
#> 1865 340844
#> 1866 340970
#> 1867 342768
#> 1868 342769
#> 1869 342770
#> 1870 343443
#> 1871 343663
#> 1872 343664
#> 1873 343689
#> 1874 343690
#> 1875 343691
#> 1876 343694
#> 1877 343695
#> 1878 343698
#> 1879 343699
#> 1880 343700
#> 1881 343701
#> 1882 343705
#> 1883 343706
#> 1884 344125
#> 1885 344230
#> 1886 344236
#> 1887 344463
#> 1888 344541
#> 1889 344664
#> 1890 344805
#> 1891 344806
#> 1892 344807
#> 1893 344808
#> 1894 344809
#> 1895 344810
#> 1896 344811
#> 1897 345361
#> 1898 345925
#> 1899 345926
#> 1900 345927
#> 1901 346017
#> 1902 346019
#> 1903 346248
#> 1904 346797
#> 1905 346800
#> 1906 346958
#> 1907 346959
#> 1908 346960
#> 1909 346961
#> 1910 346962
#> 1911 346963
#> 1912 346964
#> 1913 346965
#> 1914 346966
#> 1915 346967
#> 1916 346968
#> 1917 346969
#> 1918 347038
#> 1919 347039
#> 1920 347040
#> 1921 347041
#> 1922 347042
#> 1923 347043
#> 1924 347044
#> 1925 347045
#> 1926 347046
#> 1927 347047
#> 1928 347048
#> 1929 347049
#> 1930 347050
#> 1931 347051
#> 1932 347052
#> 1933 347053
#> 1934 347054
#> 1935 347055
#> 1936 347056
#> 1937 347057
#> 1938 347058
#> 1939 347059
#> 1940 347060
#> 1941 347061
#> 1942 347069
#> 1943 347070
#> 1944 347071
#> 1945 347072
#> 1946 347073
#> 1947 347074
#> 1948 347075
#> 1949 347076
#> 1950 347077
#> 1951 347078
#> 1952 347079
#> 1953 347080
#> 1954 347081
#> 1955 347082
#> 1956 347083
#> 1957 347084
#> 1958 347764
#> 1959 347766
#> 1960 347767
#> 1961 347768
#> 1962 347772
#> 1963 347773
#> 1964 347774
#> 1965 347775
#> 1966 347776
#> 1967 347777
#> 1968 347778
#> 1969 347779
#> 1970 347780
#> 1971 347781
#> 1972 347782
#> 1973 347783
#> 1974 347784
#> 1975 347785
#> 1976 347786
#> 1977 347966
#> 1978 348478
#> 1979 348479
#> 1980 348480
#> 1981 348481
#> 1982 348482
#> 1983 348483
#> 1984 348484
#> 1985 348485
#> 1986 348486
#> 1987 348487
#> 1988 348488
#> 1989 348793
#> 1990 349129
#> 1991 349132
#> 1992 349133
#> 1993 349332
#> 1994 349338
#> 1995 349464
#> 1996 349467
#> 1997 349468
#> 1998 349889
#> 1999 349890
#> 2000 349891
#> 2001 350222
#> 2002 350231
#> 2003 350232
#> 2004 350233
#> 2005 350234
#> 2006 350235
#> 2007 350236
#> 2008 350239
#> 2009 350240
#> 2010 350324
#> 2011 350578
#> 2012 350579
#> 2013 350581
#> 2014 350714
#> 2015 350715
#> 2016 350722
#> 2017 351110
#> 2018 351581
#> 2019 351838
#> 2020 351841
#> 2021 352122
#> 2022 352128
#> 2023 352129
#> 2024 352130
#> 2025 352131
#> 2026 352132
#> 2027 352133
#> 2028 352134
#> 2029 352135
#> 2030 352136
#> 2031 352137
#> 2032 352138
#> 2033 352139
#> 2034 352140
#> 2035 352141
#> 2036 352142
#> 2037 352143
#> 2038 352144
#> 2039 352145
#> 2040 352146
#> 2041 352308
#> 2042 352309
#> 2043 352310
#> 2044 352311
#> 2045 352312
#> 2046 352597
#> 2047 352598
#> 2048 352599
#> 2049 352600
#> 2050 352601
#> 2051 352602
#> 2052 352603
#> 2053 352604
#> 2054 352605
#> 2055 352606
#> 2056 352607
#> 2057 352608
#> 2058 352743
#> 2059 353082
#> 2060 353125
#> 2061 353126
#> 2062 353127
#> 2063 353128
#> 2064 353129
#> 2065 353130
#> 2066 353190
#> 2067 353304
#> 2068 353352
#> 2069 353365
#> 2070 353366
#> 2071 353591
#> 2072 353592
#> 2073 353595
#> 2074 353597
#> 2075 353962
#> 2076 353964
#> 2077 353965
#> 2078 353967
#> 2079 353968
#> 2080 353969
#> 2081 353970
#> 2082 353971
#> 2083 353972
#> 2084 353973
#> 2085 353974
#> 2086 353975
#> 2087 353976
#> 2088 353977
#> 2089 353978
#> 2090 353979
#> 2091 353980
#> 2092 353981
#> 2093 353982
#> 2094 353983
#> 2095 353984
#> 2096 353985
#> 2097 353986
#> 2098 353987
#> 2099 353988
#> 2100 353989
#> 2101 353990
#> 2102 353991
#> 2103 353992
#> 2104 353993
#> 2105 353994
#> 2106 353995
#> 2107 353996
#> 2108 353997
#> 2109 354195
#> 2110 354196
#> 2111 354197
#> 2112 354198
#> 2113 354199
#> 2114 354200
#> 2115 354201
#> 2116 354202
#> 2117 354203
#> 2118 354204
#> 2119 354205
#> 2120 354206
#> 2121 354207
#> 2122 354208
#> 2123 354209
#> 2124 354210
#> 2125 354211
#> 2126 354212
#> 2127 354213
#> 2128 354214
#> 2129 354215
#> 2130 354216
#> 2131 354217
#> 2132 354218
#> 2133 354219
#> 2134 354220
#> 2135 354221
#> 2136 354222
#> 2137 354223
#> 2138 354224
#> 2139 354225
#> 2140 354226
#> 2141 354227
#> 2142 354228
#> 2143 354229
#> 2144 354230
#> 2145 354231
#> 2146 354232
#> 2147 354233
#> 2148 354234
#> 2149 354235
#> 2150 355399
#> 2151 355412
#> 2152 355718
#> 2153 355864
#> 2154 356106
#> 2155 356107
#> 2156 356379
#> 2157 356397
#> 2158 356410
#> 2159 356549
#> 2160 356581
#> 2161 357047
#> 2162 357100
#> 2163 357101
#> 2164 357227
#> 2165 357264
#> 2166 357917
#> 2167 357918
#> 2168 357919
#> 2169 357920
#> 2170 358244
#> 2171 358470
#> 2172 358471
#> 2173 358472
#> 2174 358473
#> 2175 358663
#> 2176 358664
#> 2177 358667
#> 2178 358668
#> 2179 358913
#> 2180 358975
#> 2181 358976
#> 2182 359887
#> 2183 360015
#> 2184 360016
#> 2185 360215
#> 2186 360387
#> 2187 360620
#> 2188 360621
#> 2189 360622
#> 2190 360623
#> 2191 360624
#> 2192 360625
#> 2193 360626
#> 2194 361125
#> 2195 361236
#> 2196 361406
#> 2197 361454
#> 2198 361610
#> 2199 361660
#> 2200 361904
#> 2201 361905
#> 2202 361906
#> 2203 361907
#> 2204 361908
#> 2205 361909
#> 2206 361910
#> 2207 361911
#> 2208 361912
#> 2209 361913
#> 2210 361914
#> 2211 361915
#> 2212 361916
#> 2213 361917
#> 2214 361918
#> 2215 361919
#> 2216 361920
#> 2217 361921
#> 2218 361922
#> 2219 361923
#> 2220 361924
#> 2221 361925
#> 2222 361926
#> 2223 361927
#> 2224 361928
#> 2225 361983
#> 2226 362095
#> 2227 362096
#> 2228 362162
#> 2229 362174
#> 2230 362397
#> 2231 362398
#> 2232 362769
#> 2233 362780
#> 2234 363461
#> 2235 363462
#> 2236 363463
#> 2237 363464
#> 2238 363466
#> 2239 363592
#> 2240 363795
#> 2241 363796
#> 2242 363797
#> 2243 364280
#> 2244 364435
#> 2245 364460
#> 2246 364813
#> 2247 364865
#> 2248 365322
#> 2249 366749
#> 2250 366768
#> 2251 366769
#> 2252 367215
#> 2253 367606
#> 2254 367934
#> 2255 368013
#> 2256 368014
#> 2257 368015
#> 2258 368016
#> 2259 368017
#> 2260 368018
#> 2261 368019
#> 2262 368587
#> 2263 370457
#> 2264 370587
#> 2265 370588
#> 2266 370589
#> 2267 370611
#> 2268 370612
#> 2269 370615
#> 2270 370616
#> 2271 370647
#> 2272 370648
#> 2273 370649
#> 2274 370650
#> 2275 370651
#> 2276 370652
#> 2277 370653
#> 2278 370654
#> 2279 370655
#> 2280 370656
#> 2281 370657
#> 2282 370658
#> 2283 370659
#> 2284 370660
#> 2285 370661
#> 2286 370662
#> 2287 370663
#> 2288 370664
#> 2289 370665
#> 2290 370666
#> 2291 370667
#> 2292 370701
#> 2293 370702
#> 2294 370707
#> 2295 370708
#> 2296 370709
#> 2297 370710
#> 2298 370711
#> 2299 370712
#> 2300 370713
#> 2301 370714
#> 2302 370715
#> 2303 370722
#> 2304 370941
#> 2305 370942
#> 2306 370991
#> 2307 370992
#> 2308 371221
#> 2309 371512
#> 2310 373073
#> 2311 373083
#> 2312 373086
#> 2313 373131
#> 2314 373865
#> 2315 374095
#> 2316 374769
#> 2317 374770
#> 2318 374771
#> 2319 374812
#> 2320 375386
#> 2321 375864
#> 2322 375865
#> 2323 376340
#> 2324 376341
#> 2325 376360
#> 2326 376506
#> 2327 376542
#> 2328 377269
#> 2329 377285
#> 2330 377286
#> 2331 377287
#> 2332 377288
#> 2333 377289
#> 2334 377290
#> 2335 377291
#> 2336 377292
#> 2337 377293
#> 2338 377294
#> 2339 377295
#> 2340 377296
#> 2341 377297
#> 2342 377298
#> 2343 377299
#> 2344 377300
#> 2345 377301
#> 2346 377302
#> 2347 377303
#> 2348 377304
#> 2349 377305
#> 2350 377306
#> 2351 377307
#> 2352 377308
#> 2353 377309
#> 2354 377310
#> 2355 377311
#> 2356 377312
#> 2357 377313
#> 2358 377314
#> 2359 377315
#> 2360 377316
#> 2361 377317
#> 2362 377318
#> 2363 377319
#> 2364 377320
#> 2365 377321
#> 2366 377322
#> 2367 377323
#> 2368 377324
#> 2369 377325
#> 2370 377326
#> 2371 377327
#> 2372 377328
#> 2373 377329
#> 2374 377330
#> 2375 377331
#> 2376 377332
#> 2377 377333
#> 2378 377334
#> 2379 377335
#> 2380 377336
#> 2381 377337
#> 2382 377338
#> 2383 377339
#> 2384 377340
#> 2385 377341
#> 2386 377342
#> 2387 377343
#> 2388 377550
#> 2389 377606
#> 2390 377622
#> 2391 377623
#> 2392 377624
#> 2393 377625
#> 2394 377626
#> 2395 378027
#> 2396 378039
#> 2397 378139
#> 2398 378140
#> 2399 378141
#> 2400 378142
#> 2401 378143
#> 2402 378181
#> 2403 378481
#> 2404 379196
#> 2405 379284
#> 2406 379439
#> 2407 379685
#> 2408 379700
#> 2409 379701
#> 2410 379702
#> 2411 379703
#> 2412 379735
#> 2413 379736
#> 2414 379820
#> 2415 379821
#> 2416 379822
#> 2417 379823
#> 2418 379845
#> 2419 379896
#> 2420 380044
#> 2421 380051
#> 2422 380114
#> 2423 380115
#> 2424 380116
#> 2425 380117
#> 2426 380118
#> 2427 380127
#> 2428 380128
#> 2429 380362
#> 2430 380470
#> 2431 380471
#> 2432 380586
#> 2433 381150
#> 2434 381477
#> 2435 381494
#> 2436 381495
#> 2437 381496
#> 2438 381497
#> 2439 381673
#> 2440 381674
#> 2441 381677
#> 2442 381678
#> 2443 381679
#> 2444 381680
#> 2445 381681
#> 2446 381682
#> 2447 381683
#> 2448 381684
#> 2449 381685
#> 2450 381686
#> 2451 381687
#> 2452 381688
#> 2453 381689
#> 2454 381690
#> 2455 381691
#> 2456 381692
#> 2457 381693
#> 2458 381694
#> 2459 381695
#> 2460 381696
#> 2461 381717
#> 2462 381718
#> 2463 381720
#> 2464 381721
#> 2465 381722
#> 2466 381723
#> 2467 381724
#> 2468 381725
#> 2469 381726
#> 2470 381738
#> 2471 381739
#> 2472 381740
#> 2473 381741
#> 2474 381742
#> 2475 381743
#> 2476 381744
#> 2477 381745
#> 2478 381746
#> 2479 381747
#> 2480 381758
#> 2481 381759
#> 2482 381760
#> 2483 381761
#> 2484 381762
#> 2485 381763
#> 2486 381764
#> 2487 381765
#> 2488 381766
#> 2489 381767
#> 2490 381778
#> 2491 381779
#> 2492 381780
#> 2493 381781
#> 2494 381782
#> 2495 381783
#> 2496 381784
#> 2497 381785
#> 2498 381786
#> 2499 381787
#> 2500 381933
#> 2501 381936
#> 2502 381985
#> 2503 382092
#> 2504 382342
#> 2505 382679
#> 2506 382680
#> 2507 382681
#> 2508 382851
#> 2509 382918
#> 2510 383028
#> 2511 383188
#> 2512 383216
#> 2513 383438
#> 2514 383506
#> 2515 383507
#> 2516 383508
#> 2517 383509
#> 2518 383795
#> 2519 383913
#> 2520 383914
#> 2521 383915
#> 2522 383916
#> 2523 383918
#> 2524 383919
#> 2525 384919
#> 2526 385103
#> 2527 385160
#> 2528 385161
#> 2529 385290
#> 2530 385291
#> 2531 385302
#> 2532 385303
#> 2533 385306
#> 2534 385307
#> 2535 385318
#> 2536 385319
#> 2537 385575
#> 2538 385576
#> 2539 385577
#> 2540 385578
#> 2541 385579
#> 2542 385580
#> 2543 385581
#> 2544 385582
#> 2545 385583
#> 2546 385689
#> 2547 385690
#> 2548 385693
#> 2549 385694
#> 2550 386306
#> 2551 386307
#> 2552 386400
#> 2553 386692
#> 2554 387073
#> 2555 387074
#> 2556 387581
#> 2557 387596
#> 2558 387597
#> 2559 387602
#> 2560 387605
#> 2561 387694
#> 2562 387748
#> 2563 387751
#> 2564 387752
#> 2565 387753
#> 2566 387754
#> 2567 387755
#> 2568 387756
#> 2569 387757
#> 2570 387848
#> 2571 387966
#> 2572 388256
#> 2573 388756
#> 2574 390237
#> 2575 390285
#> 2576 390286
#> 2577 390287
#> 2578 390289
#> 2579 390290
#> 2580 390292
#> 2581 390533
#> 2582 390534
#> 2583 390535
#> 2584 390536
#> 2585 391725
#> 2586 391726
#> 2587 391730
#> 2588 391731
#> 2589 391754
#> 2590 391758
#> 2591 391759
#> 2592 391865
#> 2593 391871
#> 2594 391883
#> 2595 392065
#> 2596 392187
#> 2597 392188
#> 2598 392305
#> 2599 392334
#> 2600 392335
#> 2601 392340
#> 2602 392341
#> 2603 392419
#> 2604 392699
#> 2605 392759
#> 2606 392760
#> 2607 392832
#> 2608 392833
#> 2609 392836
#> 2610 392837
#> 2611 392842
#> 2612 392843
#> 2613 392844
#> 2614 392845
#> 2615 392956
#> 2616 393023
#> 2617 393024
#> 2618 393149
#> 2619 393327
#> 2620 393328
#> 2621 393329
#> 2622 393331
#> 2623 393332
#> 2624 393333
#> 2625 393334
#> 2626 393335
#> 2627 393336
#> 2628 393337
#> 2629 393338
#> 2630 393778
#> 2631 393883
#> 2632 393902
#> 2633 393903
#> 2634 393904
#> 2635 393969
#> 2636 393971
#> 2637 393972
#> 2638 394305
#> 2639 394406
#> 2640 394424
#> 2641 394428
#> 2642 394430
#> 2643 394431
#> 2644 394432
#> 2645 394433
#> 2646 394434
#> 2647 394435
#> 2648 394436
#> 2649 394437
#> 2650 394438
#> 2651 394439
#> 2652 394440
#> 2653 394441
#> 2654 394442
#> 2655 394769
#> 2656 394859
#> 2657 394861
#> 2658 394862
#> 2659 394863
#> 2660 394864
#> 2661 394865
#> 2662 394866
#> 2663 394867
#> 2664 394868
#> 2665 394869
#> 2666 394870
#> 2667 394871
#> 2668 394872
#> 2669 394873
#> 2670 395461
#> 2671 395608
#> 2672 395609
#> 2673 395610
#> 2674 396239
#> 2675 396244
#> 2676 396370
#> 2677 397046
#> 2678 397651
#> 2679 397652
#> 2680 397955
#> 2681 398539
#> 2682 398661
#> 2683 399049
#> 2684 399050
#> 2685 399176
#> 2686 399903
#> 2687 400016
#> 2688 400017
#> 2689 400018
#> 2690 400019
#> 2691 400020
#> 2692 400021
#> 2693 400065
#> 2694 400350
#> 2695 400946
#> 2696 401249
#> 2697 401378
#> 2698 401550
#> 2699 401564
#> 2700 401565
#> 2701 401566
#> 2702 401567
#> 2703 401568
#> 2704 401569
#> 2705 401593
#> 2706 401630
#> 2707 401844
#> 2708 401941
#> 2709 401978
#> 2710 402235
#> 2711 402266
#> 2712 402305
#> 2713 402342
#> 2714 402501
#> 2715 402636
#> 2716 402660
#> 2717 402698
#> 2718 402782
#> 2719 402784
#> 2720 402787
#> 2721 402790
#> 2722 403063
#> 2723 403327
#> 2724 403329
#> 2725 403330
#> 2726 403331
#> 2727 403686
#> 2728 403733
#> 2729 403734
#> 2730 404114
#> 2731 404183
#> 2732 404189
#> 2733 404583
#> 2734 405141
#> 2735 405551
#> 2736 405928
#> 2737 406460
#> 2738 406462
#> 2739 407951
#> 2740 407957
#> 2741 408258
#> 2742 408663
#> 2743 408914
#> 2744 409606
#> 2745 409608
#> 2746 409610
#> 2747 409612
#> 2748 409614
#> 2749 409615
#> 2750 409616
#> 2751 409672
#> 2752 409722
#> 2753 410367
#> 2754 410517
#> 2755 410518
#> 2756 410519
#> 2757 410521
#> 2758 410678
#> 2759 410679
#> 2760 410680
#> 2761 410681
#> 2762 410682
#> 2763 410683
#> 2764 410684
#> 2765 410685
#> 2766 410686
#> 2767 410687
#> 2768 410688
#> 2769 410689
#> 2770 410690
#> 2771 410917
#> 2772 411253
#> 2773 411254
#> 2774 411256
#> 2775 411432
#> 2776 411499
#> 2777 411589
#> 2778 411590
#> 2779 411591
#> 2780 411592
#> 2781 411593
#> 2782 411594
#> 2783 411595
#> 2784 411730
#> 2785 411744
#> 2786 411745
#> 2787 411746
#> 2788 411747
#> 2789 411748
#> 2790 411749
#> 2791 411750
#> 2792 411751
#> 2793 411752
#> 2794 411753
#> 2795 411754
#> 2796 411755
#> 2797 411757
#> 2798 411763
#> 2799 411764
#> 2800 411765
#> 2801 411766
#> 2802 411768
#> 2803 411770
#> 2804 411772
#> 2805 411774
#> 2806 411952
#> 2807 411954
#> 2808 411956
#> 2809 411958
#> 2810 411960
#> 2811 411962
#> 2812 414273
#> 2813 414719
#> 2814 414720
#> 2815 414780
#> 2816 414782
#> 2817 415546
#> 2818 415925
#> 2819 416202
#> 2820 416332
#> 2821 416431
#> 2822 416432
#> 2823 416462
#> 2824 416748
#> 2825 416749
#> 2826 416764
#> 2827 416766
#> 2828 416990
#> 2829 417010
#> 2830 417011
#> 2831 417012
#> 2832 417067
#> 2833 417068
#> 2834 417087
#> 2835 417451
#> 2836 417477
#> 2837 417481
#> 2838 417483
#> 2839 417484
#> 2840 417672
#> 2841 418902
#> 2842 418903
#> 2843 419184
#> 2844 419185
#> 2845 419186
#> 2846 419187
#> 2847 419188
#> 2848 419189
#> 2849 419190
#> 2850 419191
#> 2851 419192
#> 2852 419193
#> 2853 419312
#> 2854 419313
#> 2855 419314
#> 2856 419318
#> 2857 419319
#> 2858 419320
#> 2859 419324
#> 2860 419584
#> 2861 419597
#> 2862 419598
#> 2863 419599
#> 2864 419600
#> 2865 420326
#> 2866 420360
#> 2867 420361
#> 2868 420362
#> 2869 420363
#> 2870 420364
#> 2871 420502
#> 2872 420973
#> 2873 420976
#> 2874 420977
#> 2875 420978
#> 2876 421187
#> 2877 421210
#> 2878 421212
#> 2879 421213
#> 2880 421214
#> 2881 421216
#> 2882 421217
#> 2883 421218
#> 2884 421224
#> 2885 421522
#> 2886 421524
#> 2887 421549
#> 2888 421550
#> 2889 421685
#> 2890 421720
#> 2891 422054
#> 2892 422118
#> 2893 422226
#> 2894 422396
#> 2895 422519
#> 2896 423405
#> 2897 423411
#> 2898 423414
#> 2899 423415
#> 2900 423416
#> 2901 423636
#> 2902 423825
#> 2903 423827
#> 2904 423829
#> 2905 423831
#> 2906 423857
#> 2907 423858
#> 2908 423983
#> 2909 423984
#> 2910 423985
#> 2911 424740
#> 2912 424777
#> 2913 424778
#> 2914 424779
#> 2915 424823
#> 2916 424987
#> 2917 424988
#> 2918 424989
#> 2919 424990
#> 2920 424991
#> 2921 424992
#> 2922 424993
#> 2923 424994
#> 2924 424995
#> 2925 424996
#> 2926 424997
#> 2927 424998
#> 2928 425031
#> 2929 425037
#> 2930 425172
#> 2931 425173
#> 2932 425174
#> 2933 425175
#> 2934 425176
#> 2935 425177
#> 2936 425178
#> 2937 425179
#> 2938 425180
#> 2939 425181
#> 2940 425182
#> 2941 425183
#> 2942 425184
#> 2943 425185
#> 2944 425186
#> 2945 425187
#> 2946 425188
#> 2947 425638
#> 2948 425639
#> 2949 425640
#> 2950 426069
#> 2951 426106
#> 2952 426174
#> 2953 426175
#> 2954 426320
#> 2955 426413
#> 2956 426414
#> 2957 426415
#> 2958 426416
#> 2959 426417
#> 2960 426719
#> 2961 426819
#> 2962 426823
#> 2963 426824
#> 2964 426825
#> 2965 426828
#> 2966 426831
#> 2967 426911
#> 2968 426912
#> 2969 426954
#> 2970 427179
#> 2971 427182
#> 2972 427183
#> 2973 427184
#> 2974 427185
#> 2975 427186
#> 2976 427283
#> 2977 427441
#> 2978 427444
#> 2979 427748
#> 2980 427929
#> 2981 427967
#> 2982 427968
#> 2983 427969
#> 2984 427970
#> 2985 427971
#> 2986 427973
#> 2987 427974
#> 2988 427975
#> 2989 427976
#> 2990 427981
#> 2991 428031
#> 2992 428033
#> 2993 428034
#> 2994 428041
#> 2995 428043
#> 2996 428047
#> 2997 428567
#> 2998 429351
#> 2999 429377
#> 3000 430067
#> 3001 430068
#> 3002 430358
#> 3003 430377
#> 3004 430742
#> 3005 430823
#> 3006 430824
#> 3007 430825
#> 3008 430826
#> 3009 430827
#> 3010 430828
#> 3011 430829
#> 3012 430909
#> 3013 430910
#> 3014 430911
#> 3015 430912
#> 3016 430913
#> 3017 430914
#> 3018 430915
#> 3019 430921
#> 3020 430922
#> 3021 430923
#> 3022 430990
#> 3023 431815
#> 3024 432026
#> 3025 432066
#> 3026 432174
#> 3027 432175
#> 3028 432177
#> 3029 432178
#> 3030 432187
#> 3031 432360
#> 3032 432361
#> 3033 432362
#> 3034 432363
#> 3035 432364
#> 3036 432365
#> 3037 432366
#> 3038 432367
#> 3039 432368
#> 3040 432369
#> 3041 432370
#> 3042 432371
#> 3043 432373
#> 3044 432374
#> 3045 432375
#> 3046 432376
#> 3047 432377
#> 3048 432378
#> 3049 432379
#> 3050 432380
#> 3051 432381
#> 3052 432382
#> 3053 432383
#> 3054 432400
#> 3055 433286
#> 3056 433287
#> 3057 433288
#> 3058 433289
#> 3059 433290
#> 3060 433291
#> 3061 433292
#> 3062 433293
#> 3063 433721
#> 3064 433722
#> 3065 433723
#> 3066 434133
#> 3067 434306
#> 3068 434312
#> 3069 434313
#> 3070 434314
#> 3071 434328
#> 3072 434329
#> 3073 434709
#> 3074 434710
#> 3075 434711
#> 3076 434712
#> 3077 434713
#> 3078 434714
#> 3079 434865
#> 3080 435446
#> 3081 435943
#> 3082 436674
#> 3083 436724
#> 3084 436725
#> 3085 436726
#> 3086 436985
#> 3087 436988
#> 3088 437001
#> 3089 437154
#> 3090 437157
#> 3091 437160
#> 3092 437360
#> 3093 437361
#> 3094 437362
#> 3095 438045
#> 3096 438046
#> 3097 438047
#> 3098 438216
#> 3099 438218
#> 3100 438220
#> 3101 438783
#> 3102 439709
#> 3103 441607
#> 3104 441608
#> 3105 441616
#> 3106 441617
#> 3107 441811
#> 3108 441812
#> 3109 442504
#> 3110 442544
#> 3111 443312
#> 3112 443467
#> 3113 443590
#> 3114 443591
#> 3115 443718
#> 3116 443719
#> 3117 443720
#> 3118 443721
#> 3119 443722
#> 3120 443723
#> 3121 443930
#> 3122 443931
#> 3123 443933
#> 3124 443967
#> 3125 443968
#> 3126 443969
#> 3127 444158
#> 3128 444159
#> 3129 444160
#> 3130 444165
#> 3131 444166
#> 3132 444167
#> 3133 444290
#> 3134 444894
#> 3135 445049
#> 3136 445066
#> 3137 445067
#> 3138 445069
#> 3139 445502
#> 3140 445506
#> 3141 445651
#> 3142 445855
#> 3143 445922
#> 3144 446322
#> 3145 446323
#> 3146 446324
#> 3147 446329
#> 3148 447340
#> 3149 447578
#> 3150 447579
#> 3151 447580
#> 3152 447581
#> 3153 447582
#> 3154 447583
#> 3155 447584
#> 3156 447880
#> 3157 447991
#> 3158 447992
#> 3159 448004
#> 3160 448393
#> 3161 448796
#> 3162 449217
#> 3163 449218
#> 3164 449883
#> 3165 449889
#> 3166 449979
#> 3167 449980
#> 3168 449982
#> 3169 450286
#> 3170 450295
#> 3171 450296
#> 3172 450308
#> 3173 450313
#> 3174 450675
#> 3175 450981
#> 3176 450985
#> 3177 450986
#> 3178 450993
#> 3179 450995
#> 3180 450997
#> 3181 450999
#> 3182 451001
#> 3183 451003
#> 3184 451005
#> 3185 451007
#> 3186 451009
#> 3187 451011
#> 3188 452267
#> 3189 452318
#> 3190 452325
#> 3191 452326
#> 3192 452327
#> 3193 452328
#> 3194 452329
#> 3195 452330
#> 3196 452331
#> 3197 452332
#> 3198 452333
#> 3199 452334
#> 3200 452335
#> 3201 452336
#> 3202 452337
#> 3203 452338
#> 3204 452339
#> 3205 452340
#> 3206 452341
#> 3207 452342
#> 3208 452343
#> 3209 452344
#> 3210 452345
#> 3211 452346
#> 3212 452347
#> 3213 452348
#> 3214 452349
#> 3215 452350
#> 3216 452351
#> 3217 452352
#> 3218 452353
#> 3219 452354
#> 3220 452355
#> 3221 452356
#> 3222 452357
#> 3223 452358
#> 3224 452359
#> 3225 452360
#> 3226 452361
#> 3227 452362
#> 3228 452363
#> 3229 452364
#> 3230 452403
#> 3231 452459
#> 3232 452537
#> 3233 452538
#> 3234 452539
#> 3235 452540
#> 3236 452541
#> 3237 452542
#> 3238 452543
#> 3239 452660
#> 3240 452661
#> 3241 452684
#> 3242 452774
#> 3243 453067
#> 3244 453158
#> 3245 453932
#> 3246 453933
#> 3247 453934
#> 3248 453935
#> 3249 453936
#> 3250 454765
#> 3251 454766
#> 3252 454799
#> 3253 454804
#> 3254 454809
#> 3255 454810
#> 3256 454811
#> 3257 454812
#> 3258 454813
#> 3259 454814
#> 3260 454842
#> 3261 455099
#> 3262 455100
#> 3263 455101
#> 3264 455102
#> 3265 455103
#> 3266 455104
#> 3267 455105
#> 3268 455106
#> 3269 455107
#> 3270 455108
#> 3271 455109
#> 3272 455110
#> 3273 455111
#> 3274 455112
#> 3275 455113
#> 3276 455114
#> 3277 455115
#> 3278 455142
#> 3279 455465
#> 3280 455467
#> 3281 455481
#> 3282 455482
#> 3283 455483
#> 3284 455568
#> 3285 455680
#> 3286 455681
#> 3287 455682
#> 3288 455962
#> 3289 455967
#> 3290 455991
#> 3291 456175
#> 3292 456255
#> 3293 456268
#> 3294 456667
#> 3295 456668
#> 3296 456673
#> 3297 456674
#> 3298 456675
#> 3299 456676
#> 3300 456677
#> 3301 456678
#> 3302 456795
#> 3303 456976
#> 3304 457053
#> 3305 457325
#> 3306 457781
#> 3307 457782
#> 3308 457794
#> 3309 457795
#> 3310 457949
#> 3311 457950
#> 3312 457951
#> 3313 457952
#> 3314 457954
#> 3315 458395
#> 3316 458397
#> 3317 458398
#> 3318 458883
#> 3319 459054
#> 3320 459343
#> 3321 459344
#> 3322 459821
#> 3323 459834
#> 3324 459835
#> 3325 459916
#> 3326 460046
#> 3327 460538
#> 3328 460581
#> 3329 460583
#> 3330 460585
#> 3331 460587
#> 3332 461250
#> 3333 461545
#> 3334 461637
#> 3335 461848
#> 3336 461867
#> 3337 461868
#> 3338 461869
#> 3339 461870
#> 3340 461871
#> 3341 461872
#> 3342 461873
#> 3343 461874
#> 3344 461875
#> 3345 461876
#> 3346 461877
#> 3347 461878
#> 3348 462327
#> 3349 462598
#> 3350 462600
#> 3351 462602
#> 3352 462604
#> 3353 462633
#> 3354 462635
#> 3355 462643
#> 3356 462644
#> 3357 462645
#> 3358 462646
#> 3359 462647
#> 3360 462648
#> 3361 462649
#> 3362 462650
#> 3363 462651
#> 3364 462652
#> 3365 462653
#> 3366 462654
#> 3367 462655
#> 3368 462656
#> 3369 462657
#> 3370 462658
#> 3371 462659
#> 3372 462660
#> 3373 462736
#> 3374 462744
#> 3375 462745
#> 3376 462746
#> 3377 463864
#> 3378 463865
#> 3379 463866
#> 3380 463981
#> 3381 463983
#> 3382 463988
#> 3383 464126
#> 3384 464128
#> 3385 464172
#> 3386 464175
#> 3387 464176
#> 3388 464177
#> 3389 464524
#> 3390 464526
#> 3391 464527
#> 3392 464528
#> 3393 464529
#> 3394 464530
#> 3395 464534
#> 3396 464544
#> 3397 464545
#> 3398 464546
#> 3399 464547
#> 3400 464550
#> 3401 464551
#> 3402 464552
#> 3403 464553
#> 3404 464554
#> 3405 464555
#> 3406 464556
#> 3407 464557
#> 3408 464558
#> 3409 464559
#> 3410 464598
#> 3411 465029
#> 3412 465030
#> 3413 465063
#> 3414 465068
#> 3415 465069
#> 3416 465216
#> 3417 465218
#> 3418 465220
#> 3419 465222
#> 3420 465538
#> 3421 465540
#> 3422 465541
#> 3423 465713
#> 3424 465714
#> 3425 465715
#> 3426 465716
#> 3427 465717
#> 3428 465993
#> 3429 466579
#> 3430 466905
#> 3431 466906
#> 3432 466907
#> 3433 466914
#> 3434 466916
#> 3435 467758
#> 3436 467909
#> 3437 467933
#> 3438 468049
#> 3439 468116
#> 3440 468117
#> 3441 468120
#> 3442 468134
#> 3443 468135
#> 3444 468139
#> 3445 468140
#> 3446 468174
#> 3447 468210
#> 3448 468212
#> 3449 468240
#> 3450 468370
#> 3451 468371
#> 3452 468474
#> 3453 469174
#> 3454 469187
#> 3455 469269
#> 3456 469272
#> 3457 469451
#> 3458 469452
#> 3459 469457
#> 3460 469477
#> 3461 469478
#> 3462 469808
#> 3463 469910
#> 3464 470172
#> 3465 470245
#> 3466 470446
#> 3467 470459
#> 3468 470664
#> 3469 471079
#> 3470 471085
#> 3471 471379
#> 3472 471485
#> 3473 471493
#> 3474 471494
#> 3475 471495
#> 3476 471521
#> 3477 471526
#> 3478 471527
#> 3479 471528
#> 3480 471529
#> 3481 471600
#> 3482 471601
#> 3483 471781
#> 3484 471919
#> 3485 472107
#> 3486 472334
#> 3487 472336
#> 3488 473043
#> 3489 473062
#> 3490 473063
#> 3491 473064
#> 3492 473143
#> 3493 473144
#> 3494 473145
#> 3495 473146
#> 3496 473147
#> 3497 473148
#> 3498 473208
#> 3499 473218
#> 3500 473219
#> 3501 473222
#> 3502 473227
#> 3503 473228
#> 3504 473621
#> 3505 473628
#> 3506 473629
#> 3507 473630
#> 3508 473631
#> 3509 473632
#> 3510 473633
#> 3511 473634
#> 3512 473635
#> 3513 473961
#> 3514 474055
#> 3515 474598
#> 3516 474607
#> 3517 474608
#> 3518 474611
#> 3519 474624
#> 3520 474632
#> 3521 474633
#> 3522 474634
#> 3523 474635
#> 3524 474636
#> 3525 474637
#> 3526 474638
#> 3527 474639
#> 3528 474640
#> 3529 474641
#> 3530 474642
#> 3531 474643
#> 3532 474644
#> 3533 474645
#> 3534 474646
#> 3535 475271
#> 3536 475309
#> 3537 475315
#> 3538 475316
#> 3539 475493
#> 3540 475853
#> 3541 475854
#> 3542 475860
#> 3543 475874
#> 3544 475875
#> 3545 475985
#> 3546 476560
#> 3547 476714
#> 3548 476949
#> 3549 477399
#> 3550 477401
#> 3551 477515
#> 3552 477516
#> 3553 477517
#> 3554 477525
#> 3555 477828
#> 3556 477829
#> 3557 477841
#> 3558 477849
#> 3559 477927
#> 3560 477998
#> 3561 478136
#> 3562 478141
#> 3563 478150
#> 3564 478157
#> 3565 478158
#> 3566 478159
#> 3567 478160
#> 3568 478169
#> 3569 478170
#> 3570 478171
#> 3571 478172
#> 3572 478173
#> 3573 478309
#> 3574 478330
#> 3575 478331
#> 3576 478332
#> 3577 478367
#> 3578 478368
#> 3579 478513
#> 3580 478926
#> 3581 479041
#> 3582 479043
#> 3583 479046
#> 3584 479050
#> 3585 479074
#> 3586 479075
#> 3587 479353
#> 3588 479354
#> 3589 479355
#> 3590 479357
#> 3591 479358
#> 3592 479359
#> 3593 479360
#> 3594 479361
#> 3595 479365
#> 3596 479715
#> 3597 479787
#> 3598 479908
#> 3599 479909
#> 3600 479910
#> 3601 479911
#> 3602 479991
#> 3603 479993
#> 3604 480108
#> 3605 480960
#> 3606 481145
#> 3607 481147
#> 3608 481148
#> 3609 481149
#> 3610 481150
#> 3611 481151
#> 3612 481754
#> 3613 481755
#> 3614 481758
#> 3615 481759
#> 3616 481763
#> 3617 481764
#> 3618 481765
#> 3619 481766
#> 3620 481767
#> 3621 481768
#> 3622 481769
#> 3623 481770
#> 3624 481771
#> 3625 481772
#> 3626 481773
#> 3627 481774
#> 3628 481775
#> 3629 481776
#> 3630 481777
#> 3631 481783
#> 3632 481784
#> 3633 481785
#> 3634 481786
#> 3635 481787
#> 3636 481788
#> 3637 481789
#> 3638 481790
#> 3639 481791
#> 3640 481792
#> 3641 481793
#> 3642 481794
#> 3643 481796
#> 3644 481797
#> 3645 481857
#> 3646 482108
#> 3647 482324
#> 3648 482394
#> 3649 482707
#> 3650 482708
#> 3651 482710
#> 3652 482938
#> 3653 483173
#> 3654 483623
#> 3655 483670
#> 3656 483671
#> 3657 483776
#> 3658 483980
#> 3659 484874
#> 3660 484913
#> 3661 484914
#> 3662 484915
#> 3663 485531
#> 3664 485981
#> 3665 486191
#> 3666 486598
#> 3667 486643
#> 3668 486948
#> 3669 486957
#> 3670 487230
#> 3671 487711
#> 3672 487853
#> 3673 487854
#> 3674 487873
#> 3675 488523
#> 3676 488530
#> 3677 488584
#> 3678 489353
#> 3679 489428
#> 3680 489430
#> 3681 489465
#> 3682 489578
#> 3683 489617
#> 3684 489636
#> 3685 489643
#> 3686 489677
#> 3687 489678
#> 3688 489679
#> 3689 489680
#> 3690 490009
#> 3691 490017
#> 3692 490113
#> 3693 490118
#> 3694 490120
#> 3695 490453
#> 3696 490962
#> 3697 490963
#> 3698 490964
#> 3699 491359
#> 3700 491360
#> 3701 491361
#> 3702 491362
#> 3703 491599
#> 3704 491881
#> 3705 492147
#> 3706 492168
#> 3707 492261
#> 3708 493962
#> 3709 493963
#> 3710 493964
#> 3711 493973
#> 3712 494273
#> 3713 494278
#> 3714 494280
#> 3715 494425
#> 3716 494644
#> 3717 494645
#> 3718 497315
#> 3719 497323
#> 3720 497324
#> 3721 497330
#> 3722 497386
#> 3723 497387
#> 3724 497388
#> 3725 497389
#> 3726 497391
#> 3727 497402
#> 3728 497403
#> 3729 497404
#> 3730 497405
#> 3731 497406
#> 3732 497407
#> 3733 497408
#> 3734 497409
#> 3735 497410
#> 3736 497419
#> 3737 497601
#> 3738 497602
#> 3739 497603
#> 3740 497604
#> 3741 497605
#> 3742 497925
#> 3743 498062
#> 3744 499264
#> 3745 499265
#> 3746 499280
#> 3747 499799
#> 3748 499801
#> 3749 499803
#> 3750 499882
#> 3751 499989
#> 3752 500344
#> 3753 500359
#> 3754 500360
#> 3755 500361
#> 3756 500362
#> 3757 500363
#> 3758 500364
#> 3759 500367
#> 3760 500368
#> 3761 500369
#> 3762 500370
#> 3763 500371
#> 3764 500372
#> 3765 500373
#> 3766 500374
#> 3767 500375
#> 3768 500376
#> 3769 500377
#> 3770 500378
#> 3771 500379
#> 3772 500380
#> 3773 500381
#> 3774 500382
#> 3775 500383
#> 3776 500384
#> 3777 500385
#> 3778 500386
#> 3779 500387
#> 3780 500388
#> 3781 500389
#> 3782 500390
#> 3783 500391
#> 3784 500392
#> 3785 500393
#> 3786 500394
#> 3787 500395
#> 3788 500396
#> 3789 500397
#> 3790 500398
#> 3791 500399
#> 3792 500400
#> 3793 500401
#> 3794 500402
#> 3795 500403
#> 3796 500404
#> 3797 500405
#> 3798 500406
#> 3799 500407
#> 3800 500408
#> 3801 500409
#> 3802 500410
#> 3803 500411
#> 3804 500412
#> 3805 500413
#> 3806 500414
#> 3807 500415
#> 3808 500416
#> 3809 500417
#> 3810 500418
#> 3811 500419
#> 3812 500420
#> 3813 500421
#> 3814 500422
#> 3815 500423
#> 3816 500424
#> 3817 500425
#> 3818 500426
#> 3819 500427
#> 3820 500643
#> 3821 501211
#> 3822 501214
#> 3823 501215
#> 3824 501303
#> 3825 501432
#> 3826 501465
#> 3827 501467
#> 3828 501524
#> 3829 501531
#> 3830 501532
#> 3831 501533
#> 3832 501534
#> 3833 501535
#> 3834 501536
#> 3835 501537
#> 3836 501538
#> 3837 501539
#> 3838 501774
#> 3839 501895
#> 3840 501898
#> 3841 502012
#> 3842 502353
#> 3843 502354
#> 3844 502355
#> 3845 502363
#> 3846 502391
#> 3847 502392
#> 3848 502393
#> 3849 502394
#> 3850 502395
#> 3851 502461
#> 3852 502481
#> 3853 502485
#> 3854 502496
#> 3855 502497
#> 3856 502502
#> 3857 502767
#> 3858 503100
#> 3859 503101
#> 3860 503102
#> 3861 503103
#> 3862 503104
#> 3863 503105
#> 3864 503106
#> 3865 503107
#> 3866 503108
#> 3867 503115
#> 3868 503116
#> 3869 503117
#> 3870 503118
#> 3871 503119
#> 3872 503121
#> 3873 503122
#> 3874 503125
#> 3875 503126
#> 3876 503127
#> 3877 503128
#> 3878 503129
#> 3879 503130
#> 3880 503131
#> 3881 503132
#> 3882 503133
#> 3883 503136
#> 3884 503137
#> 3885 503138
#> 3886 503139
#> 3887 503140
#> 3888 503148
#> 3889 503149
#> 3890 503150
#> 3891 503153
#> 3892 503154
#> 3893 503155
#> 3894 503156
#> 3895 503168
#> 3896 503169
#> 3897 503170
#> 3898 503171
#> 3899 503172
#> 3900 503190
#> 3901 503191
#> 3902 503192
#> 3903 503195
#> 3904 503665
#> 3905 503797
#> 3906 503814
#> 3907 503961
#> 3908 503963
#> 3909 503964
#> 3910 503965
#> 3911 503979
#> 3912 503996
#> 3913 504013
#> 3914 504030
#> 3915 504287
#> 3916 504726
#> 3917 504942
#> 3918 504944
#> 3919 506526
#> 3920 506527
#> 3921 506528
#> 3922 506529
#> 3923 506546
#> 3924 506547
#> 3925 506766
#> 3926 506767
#> 3927 506768
#> 3928 506771
#> 3929 506772
#> 3930 506774
#> 3931 506775
#> 3932 506776
#> 3933 506777
#> 3934 506778
#> 3935 506779
#> 3936 506780
#> 3937 506781
#> 3938 506782
#> 3939 506783
#> 3940 506789
#> 3941 506841
#> 3942 507025
#> 3943 507026
#> 3944 507027
#> 3945 507101
#> 3946 507102
#> 3947 507103
#> 3948 507104
#> 3949 507105
#> 3950 507106
#> 3951 507107
#> 3952 507108
#> 3953 507109
#> 3954 507110
#> 3955 507111
#> 3956 507144
#> 3957 507145
#> 3958 507146
#> 3959 507213
#> 3960 507775
#> 3961 507776
#> 3962 507777
#> 3963 507778
#> 3964 508225
#> 3965 508229
#> 3966 508230
#> 3967 510330
#> 3968 510348
#> 3969 510349
#> 3970 510364
#> 3971 510380
#> 3972 510391
#> 3973 510402
#> 3974 510403
#> 3975 510560
#> 3976 510611
#> 3977 510613
#> 3978 510614
#> 3979 510628
#> 3980 510632
#> 3981 510639
#> 3982 510837
#> 3983 511062
#> 3984 511068
#> 3985 511069
#> 3986 511219
#> 3987 511226
#> 3988 511339
#> 3989 511340
#> 3990 511341
#> 3991 511342
#> 3992 511343
#> 3993 511344
#> 3994 511345
#> 3995 511349
#> 3996 511350
#> 3997 511351
#> 3998 511352
#> 3999 511353
#> 4000 511354
#> 4001 511355
#> 4002 511356
#> 4003 511357
#> 4004 511358
#> 4005 511359
#> 4006 511360
#> 4007 511501
#> 4008 511502
#> 4009 511507
#> 4010 511516
#> 4011 511517
#> 4012 511518
#> 4013 511519
#> 4014 511520
#> 4015 511521
#> 4016 511522
#> 4017 513181
#> 4018 513192
#> 4019 513248
#> 4020 513662
#> 4021 513663
#> 4022 513664
#> 4023 513897
#> 4024 514080
#> 4025 514370
#> 4026 514382
#> 4027 514389
#> 4028 514390
#> 4029 515289
#> 4030 515519
#> 4031 515521
#> 4032 515616
#> 4033 515845
#> 4034 516377
#> 4035 516378
#> 4036 516379
#> 4037 516380
#> 4038 516587
#> 4039 516806
#> 4040 516807
#> 4041 516810
#> 4042 516811
#> 4043 517676
#> 4044 519853
#> 4045 525198
#> 4046 526106
#> 4047 526351
#> 4048 526391
#> 4049 526392
#> 4050 526774
#> 4051 527073
#> 4052 527102
#> 4053 527317
#> 4054 527319
#> 4055 527348
#> 4056 527883
#> 4057 527957
#> 4058 527963
#> 4059 527964
#> 4060 527965
#> 4061 527966
#> 4062 527967
#> 4063 527968
#> 4064 527969
#> 4065 527970
#> 4066 527971
#> 4067 527972
#> 4068 527973
#> 4069 527974
#> 4070 527975
#> 4071 527976
#> 4072 536098
#> 4073 536103
#> 4074 536105
#> 4075 536106
#> 4076 536111
#> 4077 536113
#> 4078 536117
#> 4079 536120
#> 4080 536413
#> 4081 536414
#> 4082 536415
#> 4083 536766
#> 4084 537071
#> 4085 537072
#> 4086 537073
#> 4087 537074
#> 4088 537075
#> 4089 537076
#> 4090 537077
#> 4091 537078
#> 4092 537079
#> 4093 537080
#> 4094 537081
#> 4095 537176
#> 4096 537177
#> 4097 537180
#> 4098 537181
#> 4099 537488
#> 4100 537523
#> 4101 537731
#> 4102 537845
#> 4103 537850
#> 4104 537855
#> 4105 537860
#> 4106 537865
#> 4107 537870
#> 4108 537878
#> 4109 538235
#> 4110 538326
#> 4111 538328
#> 4112 538352
#> 4113 538376
#> 4114 538377
#> 4115 538496
#> 4116 539013
#> 4117 539073
#> 4118 539076
#> 4119 539077
#> 4120 539078
#> 4121 539079
#> 4122 539080
#> 4123 539081
#> 4124 539082
#> 4125 539083
#> 4126 539084
#> 4127 539085
#> 4128 539086
#> 4129 539087
#> 4130 539088
#> 4131 539089
#> 4132 539090
#> 4133 539091
#> 4134 539092
#> 4135 539093
#> 4136 539094
#> 4137 539095
#> 4138 539096
#> 4139 539097
#> 4140 539098
#> 4141 539099
#> 4142 539100
#> 4143 539101
#> 4144 539102
#> 4145 539103
#> 4146 539104
#> 4147 539105
#> 4148 539106
#> 4149 539107
#> 4150 539108
#> 4151 539109
#> 4152 539110
#> 4153 539111
#> 4154 539112
#> 4155 539113
#> 4156 539114
#> 4157 539115
#> 4158 539116
#> 4159 539141
#> 4160 539142
#> 4161 539539
#> 4162 539541
#> 4163 539542
#> 4164 539544
#> 4165 539929
#> 4166 539930
#> 4167 539931
#> 4168 539932
#> 4169 540153
#> 4170 540154
#> 4171 540155
#> 4172 540156
#> 4173 540157
#> 4174 540158
#> 4175 540159
#> 4176 540160
#> 4177 540161
#> 4178 540162
#> 4179 540163
#> 4180 540164
#> 4181 540165
#> 4182 540166
#> 4183 540167
#> 4184 540168
#> 4185 540169
#> 4186 540170
#> 4187 540171
#> 4188 540172
#> 4189 540259
#> 4190 541365
#> 4191 542453
#> 4192 542454
#> 4193 542455
#> 4194 542456
#> 4195 542457
#> 4196 542458
#> 4197 542459
#> 4198 542460
#> 4199 542461
#> 4200 542462
#> 4201 542463
#> 4202 542464
#> 4203 542465
#> 4204 542466
#> 4205 542467
#> 4206 542468
#> 4207 542469
#> 4208 542789
#> 4209 542790
#> 4210 542791
#> 4211 542792
#> 4212 542793
#> 4213 542794
#> 4214 543210
#> 4215 543873
#> 4216 543990
#> 4217 543997
#> 4218 543998
#> 4219 543999
#> 4220 544000
#> 4221 544001
#> 4222 544064
#> 4223 544065
#> 4224 544080
#> 4225 545230
#> 4226 545854
#> 4227 545890
#> 4228 546327
#> 4229 546545
#> 4230 546560
#> 4231 546568
#> 4232 546569
#> 4233 546570
#> 4234 547109
#> 4235 548273
#> 4236 548274
#> 4237 548429
#> 4238 548430
#> 4239 548431
#> 4240 548432
#> 4241 548433
#> 4242 548434
#> 4243 548435
#> 4244 548436
#> 4245 549083
#> 4246 549145
#> 4247 549153
#> 4248 549154
#> 4249 549155
#> 4250 549156
#> 4251 549157
#> 4252 549158
#> 4253 549159
#> 4254 549160
#> 4255 549161
#> 4256 549162
#> 4257 549163
#> 4258 549164
#> 4259 549165
#> 4260 549166
#> 4261 549167
#> 4262 549168
#> 4263 549169
#> 4264 549170
#> 4265 549171
#> 4266 549172
#> 4267 549173
#> 4268 549174
#> 4269 549175
#> 4270 549179
#> 4271 549180
#> 4272 549181
#> 4273 549183
#> 4274 549184
#> 4275 549185
#> 4276 549186
#> 4277 549187
#> 4278 549188
#> 4279 549189
#> 4280 549507
#> 4281 549982
#> 4282 550083
#> 4283 550405
#> 4284 550750
#> 4285 550751
#> 4286 550752
#> 4287 550898
#> 4288 551043
#> 4289 551146
#> 4290 551585
#> 4291 551587
#> 4292 551588
#> 4293 551590
#> 4294 551591
#> 4295 551592
#> 4296 551598
#> 4297 551695
#> 4298 552122
#> 4299 552160
#> 4300 552867
#> 4301 553904
#> 4302 555964
#> 4303 555965
#> 4304 555966
#> 4305 555967
#> 4306 555968
#> 4307 555969
#> 4308 556137
#> 4309 556139
#> 4310 556140
#> 4311 556141
#> 4312 556142
#> 4313 556143
#> 4314 556144
#> 4315 556145
#> 4316 556146
#> 4317 557764
#> 4318 560411
#> 4319 560624
#> 4320 562697
#> 4321 562701
#> 4322 562702
#> 4323 562703
#> 4324 562704
#> 4325 562870
#> 4326 563848
#> 4327 563850
#> 4328 564324
#> 4329 566360
#> 4330 566527
#> 4331 566528
#> 4332 566529
#> 4333 566538
#> 4334 566539
#> 4335 566543
#> 4336 566544
#> 4337 566546
#> 4338 566547
#> 4339 566548
#> 4340 566552
#> 4341 566553
#> 4342 566554
#> 4343 566600
#> 4344 566601
#> 4345 566603
#> 4346 566625
#> 4347 566626
#> 4348 566959
#> 4349 568231
#> 4350 568593
#> 4351 568644
#> 4352 568658
#> 4353 568685
#> 4354 568720
#> 4355 568854
#> 4356 568855
#> 4357 569093
#> 4358 569097
#> 4359 569098
#> 4360 569099
#> 4361 569100
#> 4362 569101
#> 4363 569102
#> 4364 569103
#> 4365 569104
#> 4366 569105
#> 4367 569106
#> 4368 569107
#> 4369 569108
#> 4370 569109
#> 4371 569110
#> 4372 569111
#> 4373 569112
#> 4374 569113
#> 4375 569114
#> 4376 569115
#> 4377 569116
#> 4378 569117
#> 4379 569118
#> 4380 569119
#> 4381 569120
#> 4382 569121
#> 4383 569122
#> 4384 569123
#> 4385 569125
#> 4386 569242
#> 4387 569251
#> 4388 569252
#> 4389 569253
#> 4390 569254
#> 4391 569447
#> 4392 569450
#> 4393 569451
#> 4394 569937
#> 4395 569938
#> 4396 570470
#> 4397 570471
#> 4398 570473
#> 4399 570474
#> 4400 570475
#> 4401 570476
#> 4402 570479
#> 4403 570550
#> 4404 570551
#> 4405 570552
#> 4406 570580
#> 4407 570581
#> 4408 571526
#> 4409 572308
#> 4410 572767
#> 4411 572774
#> 4412 572775
#> 4413 572776
#> 4414 572777
#> 4415 572778
#> 4416 572779
#> 4417 572780
#> 4418 572781
#> 4419 572782
#> 4420 572783
#> 4421 572784
#> 4422 572785
#> 4423 572950
#> 4424 572972
#> 4425 572973
#> 4426 572974
#> 4427 572975
#> 4428 572976
#> 4429 572977
#> 4430 572985
#> 4431 572990
#> 4432 575286
#> 4433 576615
#> 4434 576624
#> 4435 578591
#> 4436 578596
#> 4437 578598
#> 4438 578601
#> 4439 580227
#> 4440 580613
#> 4441 580615
#> 4442 580633
#> 4443 580769
#> 4444 580770
#> 4445 580926
#> 4446 580927
#> 4447 581111
#> 4448 581112
#> 4449 581139
#> 4450 581758
#> 4451 581759
#> 4452 581926
#> 4453 581927
#> 4454 581949
#> 4455 581952
#> 4456 582292
#> 4457 582293
#> 4458 583610
#> 4459 583611
#> 4460 586291
#> 4461 586292
#> 4462 586293
#> 4463 586294
#> 4464 586310
#> 4465 586583
#> 4466 587201
#> 4467 587679
#> 4468 587895
#> 4469 588062
#> 4470 588064
#> 4471 588065
#> 4472 588144
#> 4473 588145
#> 4474 589259
#> 4475 589353
#> 4476 589429
#> 4477 589430
#> 4478 589480
#> 4479 589484
#> 4480 589679
#> 4481 589827
#> 4482 589828
#> 4483 589829
#> 4484 589867
#> 4485 589875
#> 4486 589880
#> 4487 589881
#> 4488 589882
#> 4489 589883
#> 4490 589987
#> 4491 589988
#> 4492 589991
#> 4493 590124
#> 4494 590319
#> 4495 590342
#> 4496 590350
#> 4497 590357
#> 4498 590456
#> 4499 590466
#> 4500 590476
#> 4501 590564
#> 4502 590574
#> 4503 590692
#> 4504 590699
#> 4505 590701
#> 4506 590715
#> 4507 590718
#> 4508 591186
#> 4509 591326
#> 4510 591327
#> 4511 591328
#> 4512 591329
#> 4513 591330
#> 4514 592153
#> 4515 592175
#> 4516 592665
#> 4517 592719
#> 4518 593415
#> 4519 593654
#> 4520 594324
#> 4521 594493
#> 4522 594565
#> 4523 594696
#> 4524 594699
#> 4525 594703
#> 4526 594783
#> 4527 594784
#> 4528 594794
#> 4529 594949
#> 4530 594964
#> 4531 594971
#> 4532 595210
#> 4533 595221
#> 4534 595459
#> 4535 595496
#> 4536 595498
#> 4537 596546
#> 4538 596859
#> 4539 597082
#> 4540 597373
#> 4541 597377
#> 4542 597378
#> 4543 597635
#> 4544 597642
#> 4545 598117
#> 4546 598807
#> 4547 598872
#> 4548 599098
#> 4549 599099
#> 4550 599172
#> 4551 599230
#> 4552 599464
#> 4553 599465
#> 4554 599466
#> 4555 599467
#> 4556 599468
#> 4557 599469
#> 4558 599470
#> 4559 599471
#> 4560 599472
#> 4561 599473
#> 4562 599474
#> 4563 599475
#> 4564 599476
#> 4565 599529
#> 4566 599552
#> 4567 599562
#> 4568 599724
#> 4569 599884
#> 4570 599941
#> 4571 599942
#> 4572 599946
#> 4573 599949
#> 4574 599950
#> 4575 599951
#> 4576 599952
#> 4577 600177
#> 4578 600178
#> 4579 600179
#> 4580 600180
#> 4581 600219
#> 4582 600224
#> 4583 600226
#> 4584 600303
#> 4585 600306
#> 4586 600307
#> 4587 600521
#> 4588 600522
#> 4589 600523
#> 4590 600524
#> 4591 600525
#> 4592 600820
#> 4593 600929
#> 4594 601146
#> 4595 601422
#> 4596 602106
#> 4597 602112
#> 4598 602113
#> 4599 602114
#> 4600 602115
#> 4601 602116
#> 4602 602117
#> 4603 602698
#> 4604 602700
#> 4605 602730
#> 4606 602731
#> 4607 602732
#> 4608 602733
#> 4609 602734
#> 4610 602735
#> 4611 602736
#> 4612 602737
#> 4613 602738
#> 4614 602739
#> 4615 602740
#> 4616 602741
#> 4617 602742
#> 4618 602743
#> 4619 602744
#> 4620 602745
#> 4621 603218
#> 4622 603532
#> 4623 603542
#> 4624 603543
#> 4625 603544
#> 4626 603545
#> 4627 603652
#> 4628 603671
#> 4629 603679
#> 4630 604029
#> 4631 604052
#> 4632 604060
#> 4633 604061
#> 4634 604062
#> 4635 604063
#> 4636 604064
#> 4637 604146
#> 4638 604147
#> 4639 604148
#> 4640 604149
#> 4641 604178
#> 4642 604339
#> 4643 604705
#> 4644 604799
#> 4645 604853
#> 4646 605298
#> 4647 605336
#> 4648 605337
#> 4649 605338
#> 4650 605340
#> 4651 605366
#> 4652 605736
#> 4653 605915
#> 4654 606020
#> 4655 606031
#> 4656 606361
#> 4657 606505
#> 4658 606541
#> 4659 606736
#> 4660 606737
#> 4661 606739
#> 4662 606740
#> 4663 606745
#> 4664 606746
#> 4665 606789
#> 4666 606792
#> 4667 606794
#> 4668 606796
#> 4669 607282
#> 4670 607295
#> 4671 607296
#> 4672 607297
#> 4673 607298
#> 4674 607299
#> 4675 607300
#> 4676 607301
#> 4677 607302
#> 4678 607303
#> 4679 607330
#> 4680 607332
#> 4681 607334
#> 4682 607336
#> 4683 607338
#> 4684 607340
#> 4685 607341
#> 4686 607342
#> 4687 607343
#> 4688 607344
#> 4689 607345
#> 4690 607346
#> 4691 607347
#> 4692 607348
#> 4693 607349
#> 4694 607350
#> 4695 607381
#> 4696 607382
#> 4697 607383
#> 4698 607384
#> 4699 607385
#> 4700 607386
#> 4701 607387
#> 4702 607388
#> 4703 607389
#> 4704 607390
#> 4705 607391
#> 4706 607392
#> 4707 607393
#> 4708 607394
#> 4709 607395
#> 4710 607396
#> 4711 607430
#> 4712 607437
#> 4713 607438
#> 4714 607439
#> 4715 607440
#> 4716 607441
#> 4717 607442
#> 4718 607453
#> 4719 607454
#> 4720 607527
#> 4721 607530
#> 4722 607532
#> 4723 607533
#> 4724 607632
#> 4725 607633
#> 4726 607634
#> 4727 607635
#> 4728 607885
#> 4729 607886
#> 4730 607890
#> 4731 608012
#> 4732 608028
#> 4733 608029
#> 4734 608030
#> 4735 608031
#> 4736 608032
#> 4737 608033
#> 4738 608034
#> 4739 608035
#> 4740 608221
#> 4741 608228
#> 4742 608238
#> 4743 608241
#> 4744 608242
#> 4745 608243
#> 4746 608244
#> 4747 608245
#> 4748 608246
#> 4749 608247
#> 4750 608248
#> 4751 608249
#> 4752 608250
#> 4753 608251
#> 4754 608252
#> 4755 608314
#> 4756 608617
#> 4757 608625
#> 4758 608633
#> 4759 608634
#> 4760 608635
#> 4761 608691
#> 4762 608708
#> 4763 608709
#> 4764 608710
#> 4765 608711
#> 4766 608712
#> 4767 608713
#> 4768 608714
#> 4769 608715
#> 4770 608716
#> 4771 608717
#> 4772 608718
#> 4773 608719
#> 4774 608720
#> 4775 608721
#> 4776 608722
#> 4777 608723
#> 4778 608724
#> 4779 608725
#> 4780 608726
#> 4781 608727
#> 4782 608728
#> 4783 608729
#> 4784 608730
#> 4785 608776
#> 4786 608804
#> 4787 608805
#> 4788 608806
#> 4789 608807
#> 4790 608808
#> 4791 608809
#> 4792 608810
#> 4793 608811
#> 4794 608812
#> 4795 608813
#> 4796 608814
#> 4797 608815
#> 4798 608816
#> 4799 608817
#> 4800 608818
#> 4801 608819
#> 4802 608820
#> 4803 608821
#> 4804 608822
#> 4805 608823
#> 4806 608825
#> 4807 608826
#> 4808 608827
#> 4809 608828
#> 4810 608850
#> 4811 608921
#> 4812 609080
#> 4813 609592
#> 4814 609598
#> 4815 609605
#> 4816 609727
#> 4817 609860
#> 4818 610161
#> 4819 610163
#> 4820 610308
#> 4821 610792
#> 4822 610869
#> 4823 610870
#> 4824 610874
#> 4825 611472
#> 4826 611688
#> 4827 611691
#> 4828 611757
#> 4829 611758
#> 4830 611759
#> 4831 611771
#> 4832 611904
#> 4833 611968
#> 4834 612537
#> 4835 612538
#> 4836 612539
#> 4837 612681
#> 4838 613180
#> 4839 613185
#> 4840 613186
#> 4841 613199
#> 4842 613200
#> 4843 613201
#> 4844 613202
#> 4845 613203
#> 4846 613204
#> 4847 613205
#> 4848 613206
#> 4849 613207
#> 4850 613210
#> 4851 613211
#> 4852 613232
#> 4853 613233
#> 4854 613249
#> 4855 613259
#> 4856 614212
#> 4857 614213
#> 4858 614214
#> 4859 614218
#> 4860 614219
#> 4861 614220
#> 4862 614343
#> 4863 614344
#> 4864 614345
#> 4865 614349
#> 4866 614350
#> 4867 614568
#> 4868 614577
#> 4869 614584
#> 4870 614944
#> 4871 615048
#> 4872 615049
#> 4873 615261
#> 4874 615264
#> 4875 615266
#> 4876 615937
#> 4877 616230
#> 4878 616231
#> 4879 616232
#> 4880 616233
#> 4881 616234
#> 4882 616235
#> 4883 616236
#> 4884 616237
#> 4885 616238
#> 4886 616240
#> 4887 616578
#> 4888 616604
#> 4889 616815
#> 4890 617013
#> 4891 617014
#> 4892 617015
#> 4893 617079
#> 4894 617082
#> 4895 617099
#> 4896 617277
#> 4897 617316
#> 4898 617367
#> 4899 617370
#> 4900 617372
#> 4901 617374
#> 4902 617376
#> 4903 617378
#> 4904 617380
#> 4905 617383
#> 4906 617545
#> 4907 617546
#> 4908 617547
#> 4909 617548
#> 4910 617549
#> 4911 617550
#> 4912 617551
#> 4913 617552
#> 4914 617553
#> 4915 617554
#> 4916 617555
#> 4917 617633
#> 4918 617634
#> 4919 617635
#> 4920 617636
#> 4921 617637
#> 4922 617638
#> 4923 617639
#> 4924 617931
#> 4925 618435
#> 4926 618436
#> 4927 618444
#> 4928 618833
#> 4929 618836
#> 4930 618940
#> 4931 618949
#> 4932 618951
#> 4933 618954
#> 4934 619062
#> 4935 619065
#> 4936 619079
#> 4937 619081
#> 4938 619082
#> 4939 619083
#> 4940 619188
#> 4941 619194
#> 4942 620246
#> 4943 620716
#> 4944 620718
#> 4945 620719
#> 4946 620720
#> 4947 620721
#> 4948 620722
#> 4949 620723
#> 4950 620724
#> 4951 620775
#> 4952 620776
#> 4953 622250
#> 4954 622254
#> 4955 622359
#> 4956 622587
#> 4957 622588
#> 4958 622589
#> 4959 622880
#> 4960 623032
#> 4961 623527
#> 4962 623528
#> 4963 625221
#> 4964 625632
#> 4965 626065
#> 4966 626066
#> 4967 626067
#> 4968 626068
#> 4969 626147
#> 4970 626148
#> 4971 626149
#> 4972 626150
#> 4973 626151
#> 4974 626152
#> 4975 626153
#> 4976 626202
#> 4977 626203
#> 4978 626303
#> 4979 626311
#> 4980 626327
#> 4981 626364
#> 4982 626370
#> 4983 626375
#> 4984 626378
#> 4985 626379
#> 4986 626380
#> 4987 626381
#> 4988 626382
#> 4989 626383
#> 4990 626446
#> 4991 626449
#> 4992 626450
#> 4993 626451
#> 4994 626453
#> 4995 626456
#> 4996 626562
#> 4997 626563
#> 4998 626564
#> 4999 626565
#> 5000 626599
#> 5001 626808
#> 5002 626809
#> 5003 626812
#> 5004 626813
#> 5005 627321
#> 5006 627322
#> 5007 627323
#> 5008 627333
#> 5009 627543
#> 5010 628210
#> 5011 628211
#> 5012 628286
#> 5013 629472
#> 5014 629473
#> 5015 629598
#> 5016 629657
#> 5017 629658
#> 5018 629659
#> 5019 629660
#> 5020 629661
#> 5021 629662
#> 5022 629663
#> 5023 629664
#> 5024 629665
#> 5025 629666
#> 5026 629667
#> 5027 629668
#> 5028 629669
#> 5029 629670
#> 5030 629671
#> 5031 629672
#> 5032 629673
#> 5033 629674
#> 5034 629675
#> 5035 629676
#> 5036 629677
#> 5037 629678
#> 5038 629679
#> 5039 630394
#> 5040 631064
#> 5041 631065
#> 5042 631066
#> 5043 631067
#> 5044 631068
#> 5045 631069
#> 5046 631070
#> 5047 632460
#> 5048 632958
#> 5049 632959
#> 5050 632960
#> 5051 632961
#> 5052 632962
#> 5053 632963
#> 5054 633104
#> 5055 633360
#> 5056 633549
#> 5057 633790
#> 5058 633793
#> 5059 633826
#> 5060 634027
#> 5061 634247
#> 5062 634248
#> 5063 634249
#> 5064 634250
#> 5065 634251
#> 5066 634252
#> 5067 634253
#> 5068 634254
#> 5069 634256
#> 5070 634257
#> 5071 634258
#> 5072 634259
#> 5073 634260
#> 5074 634261
#> 5075 634262
#> 5076 634332
#> 5077 634333
#> 5078 634334
#> 5079 634335
#> 5080 634336
#> 5081 634337
#> 5082 634338
#> 5083 634339
#> 5084 634340
#> 5085 634341
#> 5086 634342
#> 5087 634760
#> 5088 634761
#> 5089 634800
#> 5090 634831
#> 5091 634840
#> 5092 634845
#> 5093 635152
#> 5094 635155
#> 5095 635405
#> 5096 635406
#> 5097 635407
#> 5098 635408
#> 5099 635410
#> 5100 635458
#> 5101 635969
#> 5102 635970
#> 5103 635971
#> 5104 636045
#> 5105 636743
#> 5106 636803
#> 5107 636820
#> 5108 636890
#> 5109 636893
#> 5110 636972
#> 5111 637107
#> 5112 637753
#> 5113 637754
#> 5114 637836
#> 5115 638252
#> 5116 638257
#> 5117 638259
#> 5118 638260
#> 5119 638261
#> 5120 638262
#> 5121 638263
#> 5122 638664
#> 5123 638665
#> 5124 638846
#> 5125 638847
#> 5126 638848
#> 5127 638849
#> 5128 638850
#> 5129 638851
#> 5130 638852
#> 5131 638853
#> 5132 638854
#> 5133 638907
#> 5134 638908
#> 5135 639125
#> 5136 639129
#> 5137 639130
#> 5138 639210
#> 5139 639802
#> 5140 639973
#> 5141 639976
#> 5142 640295
#> 5143 640296
#> 5144 640300
#> 5145 640301
#> 5146 640938
#> 5147 641317
#> 5148 642050
#> 5149 642054
#> 5150 642096
#> 5151 642097
#> 5152 642106
#> 5153 642107
#> 5154 642108
#> 5155 642109
#> 5156 642110
#> 5157 642111
#> 5158 642112
#> 5159 642113
#> 5160 642114
#> 5161 642194
#> 5162 642312
#> 5163 642325
#> 5164 642327
#> 5165 642380
#> 5166 642381
#> 5167 642384
#> 5168 642962
#> 5169 643008
#> 5170 643012
#> 5171 643013
#> 5172 643168
#> 5173 643173
#> 5174 643200
#> 5175 643526
#> 5176 643542
#> 5177 643543
#> 5178 643544
#> 5179 643545
#> 5180 643546
#> 5181 643547
#> 5182 643548
#> 5183 643549
#> 5184 643550
#> 5185 643611
#> 5186 643612
#> 5187 643613
#> 5188 643614
#> 5189 643615
#> 5190 643616
#> 5191 643617
#> 5192 643618
#> 5193 643619
#> 5194 643620
#> 5195 643621
#> 5196 643622
#> 5197 643623
#> 5198 643624
#> 5199 643625
#> 5200 643626
#> 5201 643627
#> 5202 643628
#> 5203 643632
#> 5204 644044
#> 5205 644047
#> 5206 644081
#> 5207 644094
#> 5208 644100
#> 5209 644110
#> 5210 644286
#> 5211 644289
#> 5212 644290
#> 5213 644291
#> 5214 644292
#> 5215 644293
#> 5216 644294
#> 5217 644295
#> 5218 644296
#> 5219 644360
#> 5220 644557
#> 5221 644567
#> 5222 644784
#> 5223 644977
#> 5224 644978
#> 5225 644979
#> 5226 646311
#> 5227 646312
#> 5228 646352
#> 5229 646353
#> 5230 646482
#> 5231 647318
#> 5232 647639
#> 5233 648106
#> 5234 648266
#> 5235 648287
#> 5236 648617
#> 5237 648753
#> 5238 649241
#> 5239 649277
#> 5240 649589
#> 5241 649590
#> 5242 649591
#> 5243 649592
#> 5244 649737
#> 5245 649738
#> 5246 649739
#> 5247 649740
#> 5248 649741
#> 5249 649742
#> 5250 649743
#> 5251 649744
#> 5252 649745
#> 5253 649764
#> 5254 649767
#> 5255 649768
#> 5256 649769
#> 5257 649770
#> 5258 649771
#> 5259 649772
#> 5260 649773
#> 5261 649774
#> 5262 649775
#> 5263 649776
#> 5264 649777
#> 5265 649929
#> 5266 649930
#> 5267 649931
#> 5268 649932
#> 5269 649933
#> 5270 649934
#> 5271 649935
#> 5272 649936
#> 5273 649937
#> 5274 649938
#> 5275 649939
#> 5276 649940
#> 5277 649941
#> 5278 649942
#> 5279 649943
#> 5280 649944
#> 5281 649945
#> 5282 649946
#> 5283 649947
#> 5284 649948
#> 5285 649949
#> 5286 649950
#> 5287 649951
#> 5288 649952
#> 5289 649953
#> 5290 649954
#> 5291 649955
#> 5292 649956
#> 5293 649957
#> 5294 649958
#> 5295 649959
#> 5296 649960
#> 5297 649961
#> 5298 649962
#> 5299 649963
#> 5300 649966
#> 5301 650775
#> 5302 651774
#> 5303 651864
#> 5304 652709
#> 5305 652710
#> 5306 652711
#> 5307 652712
#> 5308 652713
#> 5309 652714
#> 5310 652715
#> 5311 652716
#> 5312 652717
#> 5313 652718
#> 5314 652719
#> 5315 652720
#> 5316 652721
#> 5317 652722
#> 5318 652723
#> 5319 652724
#> 5320 652762
#> 5321 652763
#> 5322 652764
#> 5323 653006
#> 5324 653130
#> 5325 653131
#> 5326 653132
#> 5327 653269
#> 5328 653298
#> 5329 653473
#> 5330 653534
#> 5331 653535
#> 5332 653536
#> 5333 653673
#> 5334 653674
#> 5335 654374
#> 5336 654460
#> 5337 654470
#> 5338 654560
#> 5339 654658
#> 5340 654771
#> 5341 654772
#> 5342 654773
#> 5343 654774
#> 5344 654775
#> 5345 654898
#> 5346 655140
#> 5347 655141
#> 5348 655444
#> 5349 655445
#> 5350 655470
#> 5351 656192
#> 5352 656194
#> 5353 656243
#> 5354 656244
#> 5355 656245
#> 5356 656246
#> 5357 656247
#> 5358 656248
#> 5359 656249
#> 5360 656250
#> 5361 656627
#> 5362 656926
#> 5363 656936
#> 5364 657287
#> 5365 657288
#> 5366 657512
#> 5367 657618
#> 5368 657619
#> 5369 657620
#> 5370 657621
#> 5371 657622
#> 5372 657623
#> 5373 657624
#> 5374 657625
#> 5375 657626
#> 5376 657708
#> 5377 657709
#> 5378 657710
#> 5379 658742
#> 5380 658743
#> 5381 658744
#> 5382 658745
#> 5383 658754
#> 5384 658920
#> 5385 658921
#> 5386 658922
#> 5387 658923
#> 5388 659042
#> 5389 659043
#> 5390 659044
#> 5391 659045
#> 5392 659046
#> 5393 659047
#> 5394 659048
#> 5395 659049
#> 5396 659140
#> 5397 659151
#> 5398 659152
#> 5399 659153
#> 5400 659197
#> 5401 659199
#> 5402 659200
#> 5403 659201
#> 5404 659202
#> 5405 659216
#> 5406 659217
#> 5407 659218
#> 5408 659289
#> 5409 659293
#> 5410 659405
#> 5411 659492
#> 5412 659493
#> 5413 659494
#> 5414 659495
#> 5415 659628
#> 5416 659629
#> 5417 659630
#> 5418 659631
#> 5419 659632
#> 5420 660120
#> 5421 660814
#> 5422 660815
#> 5423 660816
#> 5424 660817
#> 5425 660818
#> 5426 660820
#> 5427 660822
#> 5428 660823
#> 5429 660825
#> 5430 660829
#> 5431 661616
#> 5432 661617
#> 5433 661618
#> 5434 661619
#> 5435 662342
#> 5436 663331
#> 5437 663481
#> 5438 663537
#> 5439 664315
#> 5440 664434
#> 5441 664435
#> 5442 664436
#> 5443 664466
#> 5444 664467
#> 5445 664468
#> 5446 664473
#> 5447 664474
#> 5448 664475
#> 5449 664476
#> 5450 664683
#> 5451 664861
#> 5452 665010
#> 5453 665100
#> 5454 665105
#> 5455 665109
#> 5456 665112
#> 5457 665113
#> 5458 665114
#> 5459 665115
#> 5460 665116
#> 5461 665117
#> 5462 665118
#> 5463 665119
#> 5464 665238
#> 5465 665239
#> 5466 665240
#> 5467 665241
#> 5468 665493
#> 5469 665578
#> 5470 665588
#> 5471 666611
#> 5472 666616
#> 5473 666617
#> 5474 666618
#> 5475 666623
#> 5476 666624
#> 5477 666625
#> 5478 666740
#> 5479 667183
#> 5480 667297
#> 5481 667382
#> 5482 667383
#> 5483 667386
#> 5484 667431
#> 5485 667538
#> 5486 667541
#> 5487 667626
#> 5488 667667
#> 5489 667668
#> 5490 668822
#> 5491 668823
#> 5492 668824
#> 5493 668825
#> 5494 669155
#> 5495 669491
#> 5496 669495
#> 5497 669508
#> 5498 669509
#> 5499 669514
#> 5500 669515
#> 5501 669516
#> 5502 669517
#> 5503 669538
#> 5504 669756
#> 5505 670436
#> 5506 670486
#> 5507 670505
#> 5508 670514
#> 5509 670601
#> 5510 670602
#> 5511 670604
#> 5512 670611
#> 5513 670612
#> 5514 670613
#> 5515 670614
#> 5516 670615
#> 5517 670616
#> 5518 670617
#> 5519 670618
#> 5520 670619
#> 5521 670620
#> 5522 670621
#> 5523 670622
#> 5524 670623
#> 5525 670624
#> 5526 670625
#> 5527 670626
#> 5528 670627
#> 5529 670628
#> 5530 670629
#> 5531 670630
#> 5532 670631
#> 5533 670632
#> 5534 670633
#> 5535 670634
#> 5536 670635
#> 5537 670636
#> 5538 670637
#> 5539 670719
#> 5540 670720
#> 5541 670882
#> 5542 670883
#> 5543 670884
#> 5544 670885
#> 5545 670886
#> 5546 670887
#> 5547 671202
#> 5548 671203
#> 5549 671204
#> 5550 671205
#> 5551 671206
#> 5552 671207
#> 5553 671208
#> 5554 671209
#> 5555 671210
#> 5556 671211
#> 5557 671212
#> 5558 671279
#> 5559 671280
#> 5560 671281
#> 5561 671282
#> 5562 671321
#> 5563 671546
#> 5564 671578
#> 5565 671579
#> 5566 671582
#> 5567 671888
#> 5568 672228
#> 5569 672480
#> 5570 672481
#> 5571 672482
#> 5572 672483
#> 5573 672484
#> 5574 672526
#> 5575 672553
#> 5576 672554
#> 5577 672555
#> 5578 672556
#> 5579 672557
#> 5580 672558
#> 5581 672559
#> 5582 672560
#> 5583 672561
#> 5584 672562
#> 5585 672563
#> 5586 672564
#> 5587 672565
#> 5588 672911
#> 5589 672917
#> 5590 672918
#> 5591 672957
#> 5592 673162
#> 5593 673255
#> 5594 673285
#> 5595 673337
#> 5596 673869
#> 5597 673870
#> 5598 673871
#> 5599 673872
#> 5600 673873
#> 5601 673874
#> 5602 673875
#> 5603 673876
#> 5604 674000
#> 5605 674208
#> 5606 674224
#> 5607 674225
#> 5608 674226
#> 5609 674230
#> 5610 674231
#> 5611 674232
#> 5612 674233
#> 5613 674234
#> 5614 674235
#> 5615 674236
#> 5616 674237
#> 5617 674238
#> 5618 674239
#> 5619 674240
#> 5620 674359
#> 5621 674698
#> 5622 674934
#> 5623 674944
#> 5624 675049
#> 5625 675177
#> 5626 675178
#> 5627 675179
#> 5628 675180
#> 5629 675182
#> 5630 675183
#> 5631 675184
#> 5632 675185
#> 5633 675186
#> 5634 675296
#> 5635 675297
#> 5636 675298
#> 5637 675299
#> 5638 675842
#> 5639 675843
#> 5640 675913
#> 5641 675914
#> 5642 675915
#> 5643 675916
#> 5644 675917
#> 5645 675918
#> 5646 675980
#> 5647 675983
#> 5648 675990
#> 5649 676528
#> 5650 676545
#> 5651 676661
#> 5652 676687
#> 5653 676994
#> 5654 676995
#> 5655 676996
#> 5656 676997
#> 5657 676998
#> 5658 677405
#> 5659 677472
#> 5660 677895
#> 5661 678084
#> 5662 678087
#> 5663 678563
#> 5664 678564
#> 5665 678822
#> 5666 678827
#> 5667 678856
#> 5668 678860
#> 5669 678865
#> 5670 678866
#> 5671 678867
#> 5672 678868
#> 5673 678869
#> 5674 678988
#> 5675 679000
#> 5676 679001
#> 5677 679011
#> 5678 679118
#> 5679 679151
#> 5680 679154
#> 5681 679191
#> 5682 679318
#> 5683 679321
#> 5684 679332
#> 5685 679336
#> 5686 679337
#> 5687 679385
#> 5688 679386
#> 5689 679394
#> 5690 679395
#> 5691 679396
#> 5692 679481
#> 5693 679527
#> 5694 679528
#> 5695 679529
#> 5696 679530
#> 5697 679531
#> 5698 679532
#> 5699 679533
#> 5700 679534
#> 5701 679552
#> 5702 679553
#> 5703 679554
#> 5704 679555
#> 5705 679556
#> 5706 679557
#> 5707 679558
#> 5708 679559
#> 5709 679560
#> 5710 679563
#> 5711 679648
#> 5712 679658
#> 5713 679659
#> 5714 679684
#> 5715 679685
#> 5716 679686
#> 5717 679834
#> 5718 679836
#> 5719 679885
#> 5720 679886
#> 5721 679943
#> 5722 679958
#> 5723 679961
#> 5724 679962
#> 5725 679963
#> 5726 679969
#> 5727 679975
#> 5728 679978
#> 5729 679979
#> 5730 679984
#> 5731 679985
#> 5732 679986
#> 5733 679987
#> 5734 679994
#> 5735 680017
#> 5736 680018
#> 5737 680038
#> 5738 680039
#> 5739 680040
#> 5740 680041
#> 5741 680042
#> 5742 680043
#> 5743 680045
#> 5744 680046
#> 5745 680219
#> 5746 680220
#> 5747 680221
#> 5748 680222
#> 5749 680223
#> 5750 680224
#> 5751 680225
#> 5752 680226
#> 5753 680227
#> 5754 680228
#> 5755 680229
#> 5756 680230
#> 5757 680231
#> 5758 680232
#> 5759 680242
#> 5760 680243
#> 5761 680244
#> 5762 680325
#> 5763 680362
#> 5764 680464
#> 5765 680465
#> 5766 680466
#> 5767 680467
#> 5768 680555
#> 5769 680558
#> 5770 680566
#> 5771 680567
#> 5772 680640
#> 5773 680641
#> 5774 680642
#> 5775 680643
#> 5776 680644
#> 5777 680654
#> 5778 680655
#> 5779 680656
#> 5780 680735
#> 5781 680736
#> 5782 680737
#> 5783 680738
#> 5784 680739
#> 5785 680740
#> 5786 680741
#> 5787 680742
#> 5788 680839
#> 5789 680840
#> 5790 680844
#> 5791 680845
#> 5792 680846
#> 5793 680847
#> 5794 680848
#> 5795 680850
#> 5796 680852
#> 5797 680853
#> 5798 680854
#> 5799 680855
#> 5800 680856
#> 5801 680857
#> 5802 680858
#> 5803 680859
#> 5804 680860
#> 5805 681068
#> 5806 681077
#> 5807 681078
#> 5808 681079
#> 5809 681080
#> 5810 681099
#> 5811 681100
#> 5812 681117
#> 5813 681146
#> 5814 681147
#> 5815 681351
#> 5816 681378
#> 5817 681523
#> 5818 681524
#> 5819 681527
#> 5820 681528
#> 5821 681529
#> 5822 681530
#> 5823 681531
#> 5824 681570
#> 5825 681576
#> 5826 681607
#> 5827 681715
#> 5828 681716
#> 5829 681717
#> 5830 681718
#> 5831 681719
#> 5832 681825
#> 5833 681826
#> 5834 681835
#> 5835 681840
#> 5836 681841
#> 5837 681937
#> 5838 681938
#> 5839 681941
#> 5840 681943
#> 5841 681944
#> 5842 681945
#> 5843 681946
#> 5844 682027
#> 5845 682038
#> 5846 682063
#> 5847 682084
#> 5848 682089
#> 5849 682106
#> 5850 682112
#> 5851 682149
#> 5852 682163
#> 5853 682205
#> 5854 682221
#> 5855 682222
#> 5856 682223
#> 5857 682224
#> 5858 682225
#> 5859 682226
#> 5860 682227
#> 5861 682228
#> 5862 682229
#> 5863 682230
#> 5864 682231
#> 5865 682234
#> 5866 682235
#> 5867 682236
#> 5868 682237
#> 5869 682238
#> 5870 682239
#> 5871 682240
#> 5872 682241
#> 5873 682242
#> 5874 682243
#> 5875 682253
#> 5876 682265
#> 5877 682266
#> 5878 682267
#> 5879 682268
#> 5880 682269
#> 5881 682270
#> 5882 682271
#> 5883 682272
#> 5884 682277
#> 5885 682278
#> 5886 682279
#> 5887 682280
#> 5888 682281
#> 5889 682282
#> 5890 682283
#> 5891 682284
#> 5892 682285
#> 5893 682286
#> 5894 682487
#> 5895 682996
#> 5896 683000
#> 5897 683001
#> 5898 683220
#> 5899 683227
#> 5900 683230
#> 5901 683245
#> 5902 683246
#> 5903 683247
#> 5904 683248
#> 5905 683249
#> 5906 683250
#> 5907 683252
#> 5908 683253
#> 5909 683254
#> 5910 683255
#> 5911 683278
#> 5912 683495
#> 5913 683840
#> 5914 684449
#> 5915 685315
#> 5916 685498
#> 5917 685499
#> 5918 686928
#> 5919 687004
#> 5920 687172
#> 5921 687173
#> 5922 687339
#> 5923 687345
#> 5924 687674
#> 5925 688349
#> 5926 688888
#> 5927 689038
#> 5928 689039
#> 5929 689263
#> 5930 689621
#> 5931 689627
#> 5932 689923
#> 5933 689924
#> 5934 689925
#> 5935 689934
#> 5936 689950
#> 5937 690828
#> 5938 691424
#> 5939 691723
#> 5940 691985
#> 5941 693290
#> 5942 693370
#> 5943 693558
#> 5944 693559
#> 5945 693568
#> 5946 693569
#> 5947 693570
#> 5948 693603
#> 5949 693604
#> 5950 693715
#> 5951 693716
#> 5952 693999
#> 5953 694006
#> 5954 694829
#> 5955 694966
#> 5956 694968
#> 5957 695418
#> 5958 695448
#> 5959 695537
#> 5960 695548
#> 5961 695572
#> 5962 695819
#> 5963 695820
#> 5964 695821
#> 5965 695822
#> 5966 695823
#> 5967 695824
#> 5968 695825
#> 5969 695826
#> 5970 695827
#> 5971 695844
#> 5972 695863
#> 5973 695864
#> 5974 695923
#> 5975 695930
#> 5976 695945
#> 5977 695954
#> 5978 696200
#> 5979 696374
#> 5980 696913
#> 5981 696997
#> 5982 697008
#> 5983 697021
#> 5984 697627
#> 5985 697786
#> 5986 697788
#> 5987 697789
#> 5988 698262
#> 5989 698318
#> 5990 699060
#> 5991 699074
#> 5992 699075
#> 5993 699377
#> 5994 700328
#> 5995 700329
#> 5996 700442
#> 5997 700508
#> 5998 700510
#> 5999 700670
#> 6000 700741
#> 6001 700743
#> 6002 700745
#> 6003 700799
#> 6004 701430
#> 6005 701631
#> 6006 701857
#> 6007 701867
#> 6008 702129
#> 6009 702132
#> 6010 702636
#> 6011 702757
#> 6012 702758
#> 6013 702759
#> 6014 702919
#> 6015 702925
#> 6016 704023
#> 6017 704060
#> 6018 704061
#> 6019 704062
#> 6020 704063
#> 6021 704064
#> 6022 704065
#> 6023 704066
#> 6024 704069
#> 6025 704074
#> 6026 704076
#> 6027 704077
#> 6028 704175
#> 6029 704178
#> 6030 704181
#> 6031 704517
#> 6032 704521
#> 6033 704523
#> 6034 704524
#> 6035 705107
#> 6036 705124
#> 6037 705139
#> 6038 705154
#> 6039 705155
#> 6040 705164
#> 6041 705266
#> 6042 705444
#> 6043 705450
#> 6044 705452
#> 6045 706277
#> 6046 706411
#> 6047 706657
#> 6048 706658
#> 6049 707354
#> 6050 707523
#> 6051 707524
#> 6052 707525
#> 6053 707526
#> 6054 707527
#> 6055 707528
#> 6056 707529
#> 6057 707530
#> 6058 707531
#> 6059 707532
#> 6060 707533
#> 6061 707534
#> 6062 707535
#> 6063 707536
#> 6064 707537
#> 6065 707538
#> 6066 707539
#> 6067 707540
#> 6068 707541
#> 6069 707542
#> 6070 707543
#> 6071 708187
#> 6072 708770
#> 6073 709728
#> 6074 709729
#> 6075 709730
#> 6076 709736
#> 6077 710329
#> 6078 710848
#> 6079 711141
#> 6080 711142
#> 6081 711144
#> 6082 711166
#> 6083 711167
#> 6084 711168
#> 6085 711441
#> 6086 714115
#> 6087 714116
#> 6088 716417
#> 6089 717119
#> 6090 717120
#> 6091 717121
#> 6092 717122
#> 6093 717123
#> 6094 717124
#> 6095 717125
#> 6096 717126
#> 6097 717127
#> 6098 717128
#> 6099 717129
#> 6100 717130
#> 6101 717131
#> 6102 717132
#> 6103 717133
#> 6104 717134
#> 6105 717135
#> 6106 717137
#> 6107 717141
#> 6108 717142
#> 6109 717143
#> 6110 717155
#> 6111 717164
#> 6112 717312
#> 6113 717313
#> 6114 717546
#> 6115 717551
#> 6116 717761
#> 6117 717763
#> 6118 717764
#> 6119 717765
#> 6120 717766
#> 6121 717767
#> 6122 717768
#> 6123 717769
#> 6124 717770
#> 6125 717771
#> 6126 717807
#> 6127 717808
#> 6128 717809
#> 6129 717810
#> 6130 717811
#> 6131 717812
#> 6132 717813
#> 6133 717814
#> 6134 717815
#> 6135 717816
#> 6136 717817
#> 6137 717818
#> 6138 717819
#> 6139 717820
#> 6140 717821
#> 6141 717827
#> 6142 718282
#> 6143 718524
#> 6144 718525
#> 6145 718541
#> 6146 719100
#> 6147 719101
#> 6148 719102
#> 6149 719344
#> 6150 719601
#> 6151 720005
#> 6152 720009
#> 6153 721049
#> 6154 721281
#> 6155 721442
#> 6156 721569
#> 6157 721615
#> 6158 721616
#> 6159 721617
#> 6160 721618
#> 6161 721619
#> 6162 721620
#> 6163 721621
#> 6164 721626
#> 6165 721704
#> 6166 721705
#> 6167 721706
#> 6168 721707
#> 6169 721708
#> 6170 721839
#> 6171 721840
#> 6172 721841
#> 6173 721860
#> 6174 721861
#> 6175 721862
#> 6176 721863
#> 6177 721864
#> 6178 721865
#> 6179 721866
#> 6180 721867
#> 6181 721868
#> 6182 721869
#> 6183 721870
#> 6184 721871
#> 6185 721872
#> 6186 721874
#> 6187 721883
#> 6188 722105
#> 6189 723080
#> 6190 723241
#> 6191 723243
#> 6192 723248
#> 6193 723346
#> 6194 723482
#> 6195 723483
#> 6196 723770
#> 6197 723772
#> 6198 723784
#> 6199 723785
#> 6200 723786
#> 6201 724002
#> 6202 724344
#> 6203 724709
#> 6204 724743
#> 6205 724744
#> 6206 724955
#> 6207 725039
#> 6208 725040
#> 6209 725110
#> 6210 725111
#> 6211 725114
#> 6212 725115
#> 6213 725382
#> 6214 725387
#> 6215 725388
#> 6216 725927
#> 6217 725936
#> 6218 726038
#> 6219 726039
#> 6220 726040
#> 6221 726041
#> 6222 726042
#> 6223 726043
#> 6224 726044
#> 6225 726045
#> 6226 726047
#> 6227 726050
#> 6228 726052
#> 6229 726486
#> 6230 726487
#> 6231 726488
#> 6232 726489
#> 6233 726774
#> 6234 726775
#> 6235 726780
#> 6236 726782
#> 6237 727102
#> 6238 727103
#> 6239 727104
#> 6240 727106
#> 6241 727107
#> 6242 727108
#> 6243 727113
#> 6244 727115
#> 6245 727116
#> 6246 727117
#> 6247 727154
#> 6248 727486
#> 6249 727487
#> 6250 727488
#> 6251 727489
#> 6252 727490
#> 6253 727491
#> 6254 727492
#> 6255 727493
#> 6256 727494
#> 6257 727495
#> 6258 727496
#> 6259 727497
#> 6260 727498
#> 6261 727499
#> 6262 727500
#> 6263 727501
#> 6264 727729
#> 6265 727730
#> 6266 727766
#> 6267 728173
#> 6268 728174
#> 6269 728175
#> 6270 728176
#> 6271 728177
#> 6272 728179
#> 6273 728180
#> 6274 728261
#> 6275 728262
#> 6276 728266
#> 6277 728270
#> 6278 728271
#> 6279 728272
#> 6280 728273
#> 6281 728274
#> 6282 728275
#> 6283 728379
#> 6284 728856
#> 6285 728861
#> 6286 728862
#> 6287 728863
#> 6288 728864
#> 6289 728953
#> 6290 728954
#> 6291 728955
#> 6292 728956
#> 6293 728957
#> 6294 729242
#> 6295 729243
#> 6296 729799
#> 6297 729803
#> 6298 729805
#> 6299 729807
#> 6300 729809
#> 6301 729812
#> 6302 729816
#> 6303 729819
#> 6304 730214
#> 6305 730252
#> 6306 730641
#> 6307 730642
#> 6308 730643
#> 6309 730644
#> 6310 731061
#> 6311 731118
#> 6312 731327
#> 6313 731492
#> 6314 732003
#> 6315 732057
#> 6316 732147
#> 6317 732148
#> 6318 732149
#> 6319 732150
#> 6320 732567
#> 6321 732805
#> 6322 732878
#> 6323 733137
#> 6324 733588
#> 6325 733675
#> 6326 734069
#> 6327 734085
#> 6328 734092
#> 6329 734093
#> 6330 734094
#> 6331 734142
#> 6332 734229
#> 6333 735327
#> 6334 735328
#> 6335 735516
#> 6336 735846
#> 6337 736018
#> 6338 736173
#> 6339 736174
#> 6340 736178
#> 6341 736179
#> 6342 736180
#> 6343 736181
#> 6344 736182
#> 6345 736183
#> 6346 736184
#> 6347 736185
#> 6348 736186
#> 6349 736187
#> 6350 736188
#> 6351 736189
#> 6352 736190
#> 6353 736191
#> 6354 736192
#> 6355 736193
#> 6356 736315
#> 6357 736325
#> 6358 736521
#> 6359 736522
#> 6360 736528
#> 6361 736542
#> 6362 736543
#> 6363 736619
#> 6364 736620
#> 6365 736621
#> 6366 736622
#> 6367 736623
#> 6368 736624
#> 6369 736625
#> 6370 736626
#> 6371 736627
#> 6372 736628
#> 6373 736629
#> 6374 736630
#> 6375 736631
#> 6376 736632
#> 6377 736633
#> 6378 736634
#> 6379 736635
#> 6380 736636
#> 6381 736637
#> 6382 736638
#> 6383 736639
#> 6384 736640
#> 6385 736641
#> 6386 736642
#> 6387 736643
#> 6388 736644
#> 6389 736660
#> 6390 736665
#> 6391 736667
#> 6392 736668
#> 6393 736695
#> 6394 736696
#> 6395 736697
#> 6396 736698
#> 6397 736904
#> 6398 736905
#> 6399 737008
#> 6400 737069
#> 6401 737076
#> 6402 737077
#> 6403 737079
#> 6404 737080
#> 6405 737081
#> 6406 737082
#> 6407 737083
#> 6408 737084
#> 6409 737085
#> 6410 737086
#> 6411 737087
#> 6412 737088
#> 6413 737089
#> 6414 737090
#> 6415 737091
#> 6416 737092
#> 6417 737093
#> 6418 737094
#> 6419 737115
#> 6420 738076
#> 6421 738173
#> 6422 738174
#> 6423 738175
#> 6424 738176
#> 6425 738177
#> 6426 738178
#> 6427 738179
#> 6428 738180
#> 6429 738181
#> 6430 738182
#> 6431 738183
#> 6432 738184
#> 6433 738185
#> 6434 738186
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#> 6450 738664
#> 6451 738721
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#> 6453 739314
#> 6454 739320
#> 6455 739322
#> 6456 739855
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#> 6458 739858
#> 6459 739859
#> 6460 740169
#> 6461 740635
#> 6462 741467
#> 6463 743611
#> 6464 743725
#> 6465 744002
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#> 6467 744262
#> 6468 744270
#> 6469 744378
#> 6470 744392
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#> 6475 744477
#> 6476 744478
#> 6477 744479
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#> 6479 744481
#> 6480 744482
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#> 6483 744485
#> 6484 744486
#> 6485 744487
#> 6486 744488
#> 6487 744489
#> 6488 744490
#> 6489 744491
#> 6490 744492
#> 6491 744493
#> 6492 744494
#> 6493 744495
#> 6494 744496
#> 6495 744497
#> 6496 744498
#> 6497 744499
#> 6498 744500
#> 6499 744501
#> 6500 744502
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#> 6502 744504
#> 6503 744505
#> 6504 744506
#> 6505 744507
#> 6506 744508
#> 6507 744509
#> 6508 744510
#> 6509 744511
#> 6510 744512
#> 6511 744513
#> 6512 744514
#> 6513 744515
#> 6514 744516
#> 6515 744517
#> 6516 744518
#> 6517 744519
#> 6518 744520
#> 6519 744521
#> 6520 744522
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#> 6522 744524
#> 6523 744525
#> 6524 744526
#> 6525 744527
#> 6526 744528
#> 6527 744529
#> 6528 744530
#> 6529 744531
#> 6530 744532
#> 6531 744533
#> 6532 744534
#> 6533 744535
#> 6534 744536
#> 6535 744564
#> 6536 744567
#> 6537 744654
#> 6538 744655
#> 6539 744656
#> 6540 744657
#> 6541 744658
#> 6542 744659
#> 6543 744660
#> 6544 744661
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#> 6546 744663
#> 6547 744664
#> 6548 744665
#> 6549 744666
#> 6550 744667
#> 6551 744668
#> 6552 744669
#> 6553 744702
#> 6554 744704
#> 6555 744705
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#> 6557 744707
#> 6558 744708
#> 6559 744709
#> 6560 744710
#> 6561 744711
#> 6562 744852
#> 6563 745136
#> 6564 745139
#> 6565 745187
#> 6566 745189
#> 6567 745193
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#> 6569 745195
#> 6570 745196
#> 6571 745197
#> 6572 745198
#> 6573 745200
#> 6574 745224
#> 6575 745314
#> 6576 745703
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#> 6578 745705
#> 6579 745706
#> 6580 745718
#> 6581 745722
#> 6582 746530
#> 6583 746702
#> 6584 746703
#> 6585 746897
#> 6586 747265
#> 6587 747266
#> 6588 747377
#> 6589 747384
#> 6590 747385
#> 6591 747386
#> 6592 747387
#> 6593 747388
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#> 6595 747390
#> 6596 747391
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#> 6598 747393
#> 6599 747394
#> 6600 747395
#> 6601 747396
#> 6602 747397
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#> 6604 747399
#> 6605 747448
#> 6606 747877
#> 6607 747994
#> 6608 747996
#> 6609 747997
#> 6610 747998
#> 6611 748098
#> 6612 748099
#> 6613 748100
#> 6614 748101
#> 6615 748298
#> 6616 748299
#> 6617 748993
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#> 6619 749211
#> 6620 749216
#> 6621 749217
#> 6622 749219
#> 6623 749222
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#> 6625 749700
#> 6626 749701
#> 6627 749702
#> 6628 749703
#> 6629 749704
#> 6630 749705
#> 6631 749911
#> 6632 750108
#> 6633 750109
#> 6634 750110
#> 6635 750292
#> 6636 750452
#> 6637 750531
#> 6638 750532
#> 6639 750798
#> 6640 750835
#> 6641 751422
#> 6642 751423
#> 6643 751424
#> 6644 751425
#> 6645 751426
#> 6646 751427
#> 6647 751428
#> 6648 751429
#> 6649 751430
#> 6650 751431
#> 6651 751432
#> 6652 751433
#> 6653 751434
#> 6654 751435
#> 6655 751436
#> 6656 751437
#> 6657 751438
#> 6658 751439
#> 6659 751440
#> 6660 751441
#> 6661 751443
#> 6662 751449
#> 6663 751450
#> 6664 751451
#> 6665 751453
#> 6666 751460
#> 6667 751461
#> 6668 751462
#> 6669 751463
#> 6670 751464
#> 6671 751465
#> 6672 751466
#> 6673 751467
#> 6674 751508
#> 6675 751509
#> 6676 751510
#> 6677 753095
#> 6678 753096
#> 6679 753097
#> 6680 753098
#> 6681 753099
#> 6682 753100
#> 6683 753101
#> 6684 753102
#> 6685 753103
#> 6686 753104
#> 6687 753105
#> 6688 753106
#> 6689 753112
#> 6690 753167
#> 6691 753252
#> 6692 753253
#> 6693 753254
#> 6694 753255
#> 6695 753256
#> 6696 753257
#> 6697 753258
#> 6698 753259
#> 6699 753260
#> 6700 753277
#> 6701 753402
#> 6702 753405
#> 6703 753406
#> 6704 753407
#> 6705 753408
#> 6706 753409
#> 6707 753443
#> 6708 753444
#> 6709 753445
#> 6710 753508
#> 6711 753779
#> 6712 753784
#> 6713 754086
#> 6714 754172
#> 6715 754523
#> 6716 755037
#> 6717 755040
#> 6718 755553
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#> 6720 756454
#> 6721 756964
#> 6722 756965
#> 6723 756966
#> 6724 756967
#> 6725 757498
#> 6726 757651
#> 6727 757657
#> 6728 757662
#> 6729 757663
#> 6730 758063
#> 6731 758720
#> 6732 758821
#> 6733 758922
#> 6734 759280
#> 6735 759312
#> 6736 759547
#> 6737 759548
#> 6738 759795
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#> 6740 759977
#> 6741 760207
#> 6742 760208
#> 6743 760279
#> 6744 760297
#> 6745 760298
#> 6746 760299
#> 6747 760300
#> 6748 760301
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#> 6750 760303
#> 6751 760304
#> 6752 760305
#> 6753 760306
#> 6754 761201
#> 6755 761487
#> 6756 761584
#> 6757 761585
#> 6758 761606
#> 6759 761820
#> 6760 761821
#> 6761 761822
#> 6762 761823
#> 6763 761824
#> 6764 761825
#> 6765 761826
#> 6766 761827
#> 6767 762125
#> 6768 762126
#> 6769 762174
#> 6770 762175
#> 6771 762184
#> 6772 762457
#> 6773 762458
#> 6774 762801
#> 6775 762802
#> 6776 762803
#> 6777 762804
#> 6778 762805
#> 6779 762806
#> 6780 762817
#> 6781 762818
#> 6782 762819
#> 6783 762820
#> 6784 762821
#> 6785 763597
#> 6786 763709
#> 6787 763710
#> 6788 764124
#> 6789 764204
#> 6790 764219
#> 6791 764957
#> 6792 765131
#> 6793 765133
#> 6794 765134
#> 6795 766555
#> 6796 766662
#> 6797 766692
#> 6798 766693
#> 6799 766695
#> 6800 766708
#> 6801 766774
#> 6802 766778
#> 6803 767029
#> 6804 767036
#> 6805 767047
#> 6806 767051
#> 6807 767052
#> 6808 767053
#> 6809 767197
#> 6810 767214
#> 6811 767255
#> 6812 767267
#> 6813 767269
#> 6814 767270
#> 6815 767271
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#> 6817 767276
#> 6818 767278
#> 6819 767340
#> 6820 768048
#> 6821 768059
#> 6822 768195
#> 6823 768197
#> 6824 768198
#> 6825 768199
#> 6826 768349
#> 6827 768387
#> 6828 768754
#> 6829 768765
#> 6830 768769
#> 6831 768777
#> 6832 768778
#> 6833 768879
#> 6834 769115
#> 6835 769616
#> 6836 769676
#> 6837 769677
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#> 6839 769679
#> 6840 769680
#> 6841 769681
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#> 6843 769683
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#> 6845 769685
#> 6846 769686
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#> 6848 769688
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#> 6850 769690
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#> 6854 769694
#> 6855 769695
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#> 6857 769697
#> 6858 769698
#> 6859 769699
#> 6860 769700
#> 6861 769701
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#> 6863 769704
#> 6864 769718
#> 6865 769827
#> 6866 769828
#> 6867 769829
#> 6868 770011
#> 6869 770012
#> 6870 770282
#> 6871 770284
#> 6872 770290
#> 6873 770291
#> 6874 770323
#> 6875 770327
#> 6876 770392
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#> 6878 770443
#> 6879 770446
#> 6880 770448
#> 6881 770450
#> 6882 770477
#> 6883 770634
#> 6884 771147
#> 6885 771260
#> 6886 771400
#> 6887 771498
#> 6888 771500
#> 6889 771501
#> 6890 771526
#> 6891 771527
#> 6892 771839
#> 6893 771868
#> 6894 771925
#> 6895 772592
#> 6896 772593
#> 6897 772639
#> 6898 772649
#> 6899 772650
#> 6900 772651
#> 6901 772652
#> 6902 772655
#> 6903 772914
#> 6904 772938
#> 6905 773060
#> 6906 773702
#> 6907 773785
#> 6908 773786
#> 6909 774522
#> 6910 774528
#> 6911 775007
#> 6912 775008
#> 6913 775009
#> 6914 775010
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#> 6919 775015
#> 6920 775017
#> 6921 775572
#> 6922 775573
#> 6923 775574
#> 6924 775575
#> 6925 775578
#> 6926 775581
#> 6927 775590
#> 6928 775721
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#> 6930 775986
#> 6931 776550
#> 6932 776559
#> 6933 776711
#> 6934 776753
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#> 6937 778699
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#> 6944 779268
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#> 6948 779374
#> 6949 779718
#> 6950 780270
#> 6951 780573
#> 6952 780575
#> 6953 780591
#> 6954 780592
#> 6955 780593
#> 6956 780594
#> 6957 780595
#> 6958 780596
#> 6959 780597
#> 6960 780598
#> 6961 780599
#> 6962 780600
#> 6963 780601
#> 6964 780602
#> 6965 780603
#> 6966 780604
#> 6967 780605
#> 6968 780606
#> 6969 780607
#> 6970 780608
#> 6971 780609
#> 6972 780610
#> 6973 780611
#> 6974 780612
#> 6975 780616
#> 6976 780617
#> 6977 780736
#> 6978 780990
#> 6979 781051
#> 6980 781052
#> 6981 781079
#> 6982 781080
#> 6983 1053395
#> 6984 1053396
#> 6985 1053399
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#> 6989 1054550
#> 6990 1054719
#> 6991 1055314
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#> 6993 1055316
#> 6994 1055317
#> 6995 1055318
#> 6996 1055319
#> 6997 1055320
#> 6998 1055321
#> 6999 1055515
#> 7000 1055516
#> 7001 1055621
#> 7002 1055638
#> 7003 1055639
#> 7004 1055640
#> 7005 1055643
#> 7006 1055660
#> 7007 1055762
#> 7008 1055777
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#> 7010 1055790
#> 7011 1055791
#> 7012 1055792
#> 7013 1055806
#> 7014 1055822
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#> 7016 1055879
#> 7017 1055881
#> 7018 1055924
#> 7019 1056038
#> 7020 1056201
#> 7021 1056202
#> 7022 1056205
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#> 7024 1056418
#> 7025 1056496
#> 7026 1056895
#> 7027 1056896
#> 7028 1056897
#> 7029 1056899
#> 7030 1056902
#> 7031 1056905
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#> 7033 1056911
#> 7034 1056914
#> 7035 1056919
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#> 7037 1056921
#> 7038 1057143
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#> 7040 1057145
#> 7041 1057146
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#> 7044 1057149
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#> 7064 1057171
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#> 7067 1057274
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#> 7071 1057885
#> 7072 1057886
#> 7073 1057890
#> 7074 1057891
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#> 7076 1058533
#> 7077 1059948
#> 7078 1059949
#> 7079 1059960
#> 7080 1059961
#> 7081 1059962
#> 7082 1059963
#> 7083 1059964
#> 7084 1059965
#> 7085 1059966
#> 7086 1059967
#> 7087 1059968
#> 7088 1059969
#> 7089 1059970
#> 7090 1059971
#> 7091 1059972
#> 7092 1059973
#> 7093 1059974
#> 7094 1059975
#> 7095 1059976
#> 7096 1059977
#> 7097 1059979
#> 7098 1059982
#> 7099 1059986
#> 7100 1059990
#> 7101 1060476
#> 7102 1060754
#> 7103 1060784
#> 7104 1060785
#> 7105 1060990
#> 7106 1060992
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#> 7109 1061219
#> 7110 1061220
#> 7111 1061221
#> 7112 1061222
#> 7113 1061223
#> 7114 1061224
#> 7115 1061237
#> 7116 1061238
#> 7117 1061744
#> 7118 1061746
#> 7119 1061747
#> 7120 1061748
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#> 7122 1061750
#> 7123 1061759
#> 7124 1061760
#> 7125 1061761
#> 7126 1061762
#> 7127 1061766
#> 7128 1061800
#> 7129 1061801
#> 7130 1061917
#> 7131 1062266
#> 7132 1062365
#> 7133 1062366
#> 7134 1062367
#> 7135 1062368
#> 7136 1062369
#> 7137 1062370
#> 7138 1062371
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#> 7140 1062410
#> 7141 1062984
#> 7142 1063168
#> 7143 1063349
#> 7144 1063355
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#> 7147 1063400
#> 7148 1063401
#> 7149 1063402
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#> 7151 1063404
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#> 7156 1063409
#> 7157 1063419
#> 7158 1063420
#> 7159 1063421
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#> 7162 1063425
#> 7163 1063550
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#> 7169 1063568
#> 7170 1063569
#> 7171 1063570
#> 7172 1063571
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#> 7174 1063573
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#> 7176 1063575
#> 7177 1063576
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#> 7179 1063578
#> 7180 1063579
#> 7181 1063580
#> 7182 1063581
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#> 7184 1063583
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#> 7186 1063585
#> 7187 1063586
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#> 7189 1063588
#> 7190 1063589
#> 7191 1063590
#> 7192 1063591
#> 7193 1063592
#> 7194 1063593
#> 7195 1063999
#> 7196 1064002
#> 7197 1064218
#> 7198 1064274
#> 7199 1064454
#> 7200 1064578
#> 7201 1064587
#> 7202 1064588
#> 7203 1064614
#> 7204 1064784
#> 7205 1065175
#> 7206 1065177
#> 7207 1065397
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#> 7211 1065643
#> 7212 1066136
#> 7213 1066147
#> 7214 1066151
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#> 7216 1066176
#> 7217 1066177
#> 7218 1066178
#> 7219 1066255
#> 7220 1066461
#> 7221 1066462
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#> 7224 1066469
#> 7225 1066470
#> 7226 1066471
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#> 7228 1066719
#> 7229 1067064
#> 7230 1067094
#> 7231 1067105
#> 7232 1067106
#> 7233 1067157
#> 7234 1067266
#> 7235 1067270
#> 7236 1067273
#> 7237 1067347
#> 7238 1067842
#> 7239 1067843
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#> 7241 1067861
#> 7242 1067863
#> 7243 1068554
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#> 7245 1068556
#> 7246 1068557
#> 7247 1068558
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#> 7249 1068561
#> 7250 1068924
#> 7251 1068959
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#> 7253 1069247
#> 7254 1069333
#> 7255 1070505
#> 7256 1070519
#> 7257 1070520
#> 7258 1070873
#> 7259 1070874
#> 7260 1070875
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#> 7262 1070877
#> 7263 1073047
#> 7264 1073636
#> 7265 1073648
#> 7266 1073649
#> 7267 1073655
#> 7268 1073744
#> 7269 1074505
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#> 7271 1074507
#> 7272 1074508
#> 7273 1074511
#> 7274 1075844
#> 7275 1075968
#> 7276 1076003
#> 7277 1076052
#> 7278 1076053
#> 7279 1076057
#> 7280 1076242
#> 7281 1076279
#> 7282 1076280
#> 7283 1076281
#> 7284 1076701
#> 7285 1076702
#> 7286 1076703
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#> 7288 1076705
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#> 7290 1076707
#> 7291 1076708
#> 7292 1076709
#> 7293 1076710
#> 7294 1076711
#> 7295 1076712
#> 7296 1076713
#> 7297 1076714
#> 7298 1076715
#> 7299 1076717
#> 7300 1076838
#> 7301 1077224
#> 7302 1077225
#> 7303 1077226
#> 7304 1077228
#> 7305 1077369
#> 7306 1077393
#> 7307 1077395
#> 7308 1077648
#> 7309 1077681
#> 7310 1077718
#> 7311 1077725
#> 7312 1077977
#> 7313 1078083
#> 7314 1078085
#> 7315 1078086
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#> 7317 1078090
#> 7318 1078091
#> 7319 1078092
#> 7320 1078093
#> 7321 1078171
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#> 7323 1078173
#> 7324 1078178
#> 7325 1078184
#> 7326 1078219
#> 7327 1079548
#> 7328 1079550
#> 7329 1079553
#> 7330 1079634
#> 7331 1079702
#> 7332 1079703
#> 7333 1083332
#> 7334 1083333
#> 7335 1083341
#> 7336 1083342
#> 7337 1083343
#> 7338 1083477
#> 7339 1083520
#> 7340 1084288
#> 7341 1085011
#> 7342 1085012
#> 7343 1085013
#> 7344 1085014
#> 7345 1085808
#> 7346 1085812
#> 7347 1085819
#> 7348 1085823
#> 7349 1085827
#> 7350 1086067
#> 7351 1086305
#> 7352 1086326
#> 7353 1086327
#> 7354 1086328
#> 7355 1086329
#> 7356 1086330
#> 7357 1086608
#> 7358 1086682
#> 7359 1086908
#> 7360 1086982
#> 7361 1093429
#> 7362 1094252
#> 7363 1094871
#> 7364 1095317
#> 7365 1095318
#> 7366 1095319
#> 7367 1095320
#> 7368 1095575
#> 7369 1095576
#> 7370 1095577
#> 7371 1095593
#> 7372 1095648
#> 7373 1095854
#> 7374 1095924
#> 7375 1095934
#> 7376 1095935
#> 7377 1096447
#> 7378 1096483
#> 7379 1096525
#> 7380 1096528
#> 7381 1096531
#> 7382 1096534
#> 7383 1096536
#> 7384 1096542
#> 7385 1096653
#> 7386 1096665
#> 7387 1096775
#> 7388 1096844
#> 7389 1096845
#> 7390 1096846
#> 7391 1096847
#> 7392 1096913
#> 7393 1096914
#> 7394 1096915
#> 7395 1096916
#> 7396 1097206
#> 7397 1097209
#> 7398 1097212
#> 7399 1097217
#> 7400 1097218
#> 7401 1106042
#> 7402 1106086
#> 7403 1106262
#> 7404 1106269
#> 7405 1106270
#> 7406 1106451
#> 7407 1106452
#> 7408 1106453
#> 7409 1106454
#> 7410 1106455
#> 7411 1106456
#> 7412 1106457
#> 7413 1106458
#> 7414 1106459
#> 7415 1106460
#> 7416 1106461
#> 7417 1106462
#> 7418 1106463
#> 7419 1106464
#> 7420 1106465
#> 7421 1106547
#> 7422 1106648
#> 7423 1106649
#> 7424 1106661
#> 7425 1107044
#> 7426 1107045
#> 7427 1107046
#> 7428 1107047
#> 7429 1107048
#> 7430 1107283
#> 7431 1107295
#> 7432 1107296
#> 7433 1113462
#> 7434 1113463
#> 7435 1113464
#> 7436 1113465
#> 7437 1113477
#> 7438 1113485
#> 7439 1114106
#> 7440 1114146
#> 7441 1114147
#> 7442 1114148
#> 7443 1114149
#> 7444 1114150
#> 7445 1114151
#> 7446 1114640
#> 7447 1114641
#> 7448 1114642
#> 7449 1114643
#> 7450 1114644
#> 7451 1114645
#> 7452 1114662
#> 7453 1114665
#> 7454 1114806
#> 7455 1114813
#> 7456 1114836
#> 7457 1115490
#> 7458 1115518
#> 7459 1115786
#> 7460 1115788
#> 7461 1115793
#> 7462 1116232
#> 7463 1116233
#> 7464 1116234
#> 7465 1116235
#> 7466 1116236
#> 7467 1116237
#> 7468 1116238
#> 7469 1116239
#> 7470 1116240
#> 7471 1116241
#> 7472 1116242
#> 7473 1116243
#> 7474 1116244
#> 7475 1116245
#> 7476 1116246
#> 7477 1116247
#> 7478 1116248
#> 7479 1116249
#> 7480 1116250
#> 7481 1116251
#> 7482 1116252
#> 7483 1116253
#> 7484 1116346
#> 7485 1116449
#> 7486 1116669
#> 7487 1116670
#> 7488 1116671
#> 7489 1116672
#> 7490 1116673
#> 7491 1116674
#> 7492 1116675
#> 7493 1116678
#> 7494 1116680
#> 7495 1116773
#> 7496 1116786
#> 7497 1116902
#> 7498 1116904
#> 7499 1116906
#> 7500 1116908
#> 7501 1116910
#> 7502 1116912
#> 7503 1116914
#> 7504 1116916
#> 7505 1116919
#> 7506 1117061
#> 7507 1117347
#> 7508 1117348
#> 7509 1117349
#> 7510 1117350
#> 7511 1117351
#> 7512 1117489
#> 7513 1117490
#> 7514 1117505
#> 7515 1117512
#> 7516 1117513
#> 7517 1117514
#> 7518 1117515
#> 7519 1117516
#> 7520 1117517
#> 7521 1117520
#> 7522 1117521
#> 7523 1117522
#> 7524 1117523
#> 7525 1117722
#> 7526 1117730
#> 7527 1117732
#> 7528 1117734
#> 7529 1117735
#> 7530 1117737
#> 7531 1117738
#> 7532 1117739
#> 7533 1117740
#> 7534 1117741
#> 7535 1117742
#> 7536 1117743
#> 7537 1117747
#> 7538 1117979
#> 7539 1117984
#> 7540 1117985
#> 7541 1117986
#> 7542 1118243
#> 7543 1118312
#> 7544 1118437
#> 7545 1118438
#> 7546 1118439
#> 7547 1118440
#> 7548 1118441
#> 7549 1118442
#> 7550 1118443
#> 7551 1118444
#> 7552 1118640
#> 7553 1118641
#> 7554 1118642
#> 7555 1118654
#> 7556 1119159
#> 7557 1119160
#> 7558 1119180
#> 7559 1119254
#> 7560 1119255
#> 7561 1119712
#> 7562 1119713
#> 7563 1119718
#> 7564 1119719
#> 7565 1119722
#> 7566 1119732
#> 7567 1120305
#> 7568 1120487
#> 7569 1120489
#> 7570 1120490
#> 7571 1120491
#> 7572 1120492
#> 7573 1120493
#> 7574 1120536
#> 7575 1121254
#> 7576 1121255
#> 7577 1121256
#> 7578 1121258
#> 7579 1121328
#> 7580 1121447
#> 7581 1121568
#> 7582 1121569
#> 7583 1121570
#> 7584 1121571
#> 7585 1121572
#> 7586 1121573
#> 7587 1121574
#> 7588 1121575
#> 7589 1121576
#> 7590 1121578
#> 7591 1121600
#> 7592 1121601
#> 7593 1121633
#> 7594 1122056
#> 7595 1122388
#> 7596 1122419
#> 7597 1122420
#> 7598 1122421
#> 7599 1122422
#> 7600 1122425
#> 7601 1122426
#> 7602 1122430
#> 7603 1123971
#> 7604 1124393
#> 7605 1124440
#> 7606 1124908
#> 7607 1124911
#> 7608 1124959
#> 7609 1124960
#> 7610 1124968
#> 7611 1124999
#> 7612 1125058
#> 7613 1125064
#> 7614 1125065
#> 7615 1125072
#> 7616 1125073
#> 7617 1125074
#> 7618 1125076
#> 7619 1125077
#> 7620 1125078
#> 7621 1125079
#> 7622 1125080
#> 7623 1125081
#> 7624 1125082
#> 7625 1125083
#> 7626 1125084
#> 7627 1125085
#> 7628 1125086
#> 7629 1125087
#> 7630 1125088
#> 7631 1125089
#> 7632 1125090
#> 7633 1125091
#> 7634 1125092
#> 7635 1125093
#> 7636 1125146
#> 7637 1125363
#> 7638 1125614
#> 7639 1125615
#> 7640 1126003
#> 7641 1126004
#> 7642 1126006
#> 7643 1126007
#> 7644 1126008
#> 7645 1126541
#> 7646 1126728
#> 7647 1126729
#> 7648 1126730
#> 7649 1126841
#> 7650 1126843
#> 7651 1127159
#> 7652 1127160
#> 7653 1127198
#> 7654 1127318
#> 7655 1127346
#> 7656 1128858
#> 7657 1128863
#> 7658 1129352
#> 7659 1129486
#> 7660 1129487
#> 7661 1129488
#> 7662 1129489
#> 7663 1129732
#> 7664 1129733
#> 7665 1129734
#> 7666 1129735
#> 7667 1129736
#> 7668 1129737
#> 7669 1129738
#> 7670 1129739
#> 7671 1129740
#> 7672 1129741
#> 7673 1129838
#> 7674 1131477
#> 7675 1131478
#> 7676 1132058
#> 7677 1132059
#> 7678 1132062
#> 7679 1132063
#> 7680 1132066
#> 7681 1132829
#> 7682 1134936
#> 7683 1135869
#> 7684 1135870
#> 7685 1135895
#> 7686 1135897
#> 7687 1135899
#> 7688 1136148
#> 7689 1136870
#> 7690 1136871
#> 7691 1136872
#> 7692 1136873
#> 7693 1136874
#> 7694 1136875
#> 7695 1136876
#> 7696 1137734
#> 7697 1138210
#> 7698 1138296
#> 7699 1138304
#> 7700 1138964
#> 7701 1138965
#> 7702 1138966
#> 7703 1138967
#> 7704 1138972
#> 7705 1138973
#> 7706 1139435
#> 7707 1139706
#> 7708 1139707
#> 7709 1139711
#> 7710 1139712
#> 7711 1139713
#> 7712 1139969
#> 7713 1139970
#> 7714 1139975
#> 7715 1139976
#> 7716 1140083
#> 7717 1140084
#> 7718 1140085
#> 7719 1140087
#> 7720 1140088
#> 7721 1140301
#> 7722 1140571
#> 7723 1140574
#> 7724 1140576
#> 7725 1140617
#> 7726 1140624
#> 7727 1140625
#> 7728 1140626
#> 7729 1140627
#> 7730 1140628
#> 7731 1140629
#> 7732 1140632
#> 7733 1140633
#> 7734 1140634
#> 7735 1140635
#> 7736 1141761
#> 7737 1141832
#> 7738 1141944
#> 7739 1141999
#> 7740 1142000
#> 7741 1142034
#> 7742 1142063
#> 7743 1142064
#> 7744 1142065
#> 7745 1142066
#> 7746 1142067
#> 7747 1142070
#> 7748 1142135
#> 7749 1142274
#> 7750 1142278
#> 7751 1142285
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#> 7753 1142287
#> 7754 1142288
#> 7755 1142289
#> 7756 1142290
#> 7757 1142291
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#> 7759 1142293
#> 7760 1142294
#> 7761 1142295
#> 7762 1142296
#> 7763 1142297
#> 7764 1142298
#> 7765 1142775
#> 7766 1142777
#> 7767 1142778
#> 7768 1142779
#> 7769 1142780
#> 7770 1142781
#> 7771 1142782
#> 7772 1142783
#> 7773 1142784
#> 7774 1142785
#> 7775 1142786
#> 7776 1142787
#> 7777 1142788
#> 7778 1142789
#> 7779 1142790
#> 7780 1142791
#> 7781 1142792
#> 7782 1142793
#> 7783 1142867
#> 7784 1143493
#> 7785 1143532
#> 7786 1143574
#> 7787 1143764
#> 7788 1144812
#> 7789 1145593
#> 7790 1145781
#> 7791 1145802
#> 7792 1145826
#> 7793 1151099
#> 7794 1151255
#> 7795 1151256
#> 7796 1151257
#> 7797 1151258
#> 7798 1151259
#> 7799 1151260
#> 7800 1151261
#> 7801 1151262
#> 7802 1151263
#> 7803 1151264
#> 7804 1151265
#> 7805 1151266
#> 7806 1151267
#> 7807 1151268
#> 7808 1151269
#> 7809 1151270
#> 7810 1151271
#> 7811 1151325
#> 7812 1153038
#> 7813 1153039
#> 7814 1153049
#> 7815 1153052
#> 7816 1153053
#> 7817 1153054
#> 7818 1153055
#> 7819 1153056
#> 7820 1153064
#> 7821 1153205
#> 7822 1153274
#> 7823 1153275
#> 7824 1153284
#> 7825 1153285
#> 7826 1153286
#> 7827 1153287
#> 7828 1153288
#> 7829 1153289
#> 7830 1153290
#> 7831 1153291
#> 7832 1153404
#> 7833 1153570
#> 7834 1153575
#> 7835 1153707
#> 7836 1153716
#> 7837 1153854
#> 7838 1154180
#> 7839 1154196
#> 7840 1154197
#> 7841 1154198
#> 7842 1154199
#> 7843 1154200
#> 7844 1154201
#> 7845 1154202
#> 7846 1154203
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#> 7848 1154205
#> 7849 1154206
#> 7850 1154207
#> 7851 1154208
#> 7852 1154209
#> 7853 1154210
#> 7854 1154211
#> 7855 1154212
#> 7856 1154213
#> 7857 1154214
#> 7858 1154215
#> 7859 1154216
#> 7860 1154217
#> 7861 1154218
#> 7862 1154219
#> 7863 1154220
#> 7864 1154221
#> 7865 1154222
#> 7866 1154297
#> 7867 1154308
#> 7868 1154309
#> 7869 1154310
#> 7870 1154311
#> 7871 1154315
#> 7872 1154322
#> 7873 1154440
#> 7874 1154620
#> 7875 1154657
#> 7876 1154743
#> 7877 1154744
#> 7878 1154929
#> 7879 1154930
#> 7880 1154931
#> 7881 1154932
#> 7882 1154933
#> 7883 1154934
#> 7884 1154935
#> 7885 1154936
#> 7886 1154937
#> 7887 1154938
#> 7888 1154939
#> 7889 1154940
#> 7890 1154941
#> 7891 1154942
#> 7892 1154943
#> 7893 1155289
#> 7894 1155290
#> 7895 1155291
#> 7896 1155292
#> 7897 1155293
#> 7898 1155294
#> 7899 1155295
#> 7900 1155296
#> 7901 1155297
#> 7902 1155298
#> 7903 1155299
#> 7904 1155300
#> 7905 1155301
#> 7906 1155302
#> 7907 1155303
#> 7908 1155304
#> 7909 1155305
#> 7910 1155306
#> 7911 1155391
#> 7912 1155794
#> 7913 1156031
#> 7914 1156332
#> 7915 1156338
#> 7916 1156339
#> 7917 1156340
#> 7918 1156518
#> 7919 1156616
#> 7920 1156701
#> 7921 1158017
#> 7922 1158202
#> 7923 1158206
#> 7924 1158430
#> 7925 1158431
#> 7926 1158432
#> 7927 1158443
#> 7928 1158444
#> 7929 1158445
#> 7930 1158446
#> 7931 1158447
#> 7932 1158607
#> 7933 1158651
#> 7934 1158930
#> 7935 1159130
#> 7936 1159136
#> 7937 1159142
#> 7938 1159148
#> 7939 1159154
#> 7940 1159183
#> 7941 1159964
#> 7942 1159995
#> 7943 1160590
#> 7944 1160591
#> 7945 1160592
#> 7946 1160633
#> 7947 1160672
#> 7948 1160694
#> 7949 1160696
#> 7950 1160697
#> 7951 1160698
#> 7952 1160699
#> 7953 1160700
#> 7954 1160701
#> 7955 1160702
#> 7956 1160703
#> 7957 1160704
#> 7958 1160705
#> 7959 1160981
#> 7960 1161251
#> 7961 1161324
#> 7962 1161382
#> 7963 1161633
#> 7964 1161663
#> 7965 1161682
#> 7966 1161686
#> 7967 1161687
#> 7968 1161688
#> 7969 1161689
#> 7970 1161690
#> 7971 1161691
#> 7972 1161692
#> 7973 1162086
#> 7974 1162088
#> 7975 1162244
#> 7976 1162267
#> 7977 1162814
#> 7978 1162943
#> 7979 1162965
#> 7980 1162974
#> 7981 1162985
#> 7982 1162993
#> 7983 1163064
#> 7984 1163375
#> 7985 1163946
#> 7986 1163947
#> 7987 1163948
#> 7988 1164035
#> 7989 1164581
#> 7990 1164586
#> 7991 1164903
#> 7992 1164904
#> 7993 1165125
#> 7994 1165190
#> 7995 1165199
#> 7996 1165227
#> 7997 1165543
#> 7998 1165763
#> 7999 1166181
#> 8000 1166182
#> 8001 1166183
#> 8002 1166184
#> 8003 1166185
#> 8004 1166226
#> 8005 1166341
#> 8006 1166469
#> 8007 1166474
#> 8008 1166475
#> 8009 1166619
#> 8010 1166641
#> 8011 1167283
#> 8012 1167414
#> 8013 1167523
#> 8014 1167524
#> 8015 1167525
#> 8016 1167526
#> 8017 1167527
#> 8018 1167528
#> 8019 1167529
#> 8020 1167530
#> 8021 1167531
#> 8022 1167532
#> 8023 1167533
#> 8024 1167534
#> 8025 1167535
#> 8026 1167536
#> 8027 1167537
#> 8028 1167538
#> 8029 1167539
#> 8030 1168410
#> 8031 1168411
#> 8032 1168412
#> 8033 1168413
#> 8034 1168414
#> 8035 1168415
#> 8036 1168416
#> 8037 1168488
#> 8038 1168741
#> 8039 1168913
#> 8040 1168948
#> 8041 1168950
#> 8042 1168956
#> 8043 1168957
#> 8044 1168958
#> 8045 1169197
#> 8046 1170032
#> 8047 1170503
#> 8048 1170649
#> 8049 1170707
#> 8050 1170708
#> 8051 1170712
#> 8052 1170718
#> 8053 1170724
#> 8054 1170725
#> 8055 1171075
#> 8056 1171232
#> 8057 1171739
#> 8058 1172005
#> 8059 1172006
#> 8060 1172111
#> 8061 1172484
#> 8062 1172548
#> 8063 1172945
#> 8064 1172996
#> 8065 1173027
#> 8066 1173031
#> 8067 1173032
#> 8068 1173033
#> 8069 1173034
#> 8070 1173035
#> 8071 1173036
#> 8072 1173037
#> 8073 1173038
#> 8074 1173039
#> 8075 1173040
#> 8076 1173041
#> 8077 1173042
#> 8078 1173390
#> 8079 1173496
#> 8080 1173497
#> 8081 1173498
#> 8082 1173613
#> 8083 1173614
#> 8084 1173615
#> 8085 1173616
#> 8086 1173703
#> 8087 1173704
#> 8088 1173822
#> 8089 1173824
#> 8090 1173849
#> 8091 1173850
#> 8092 1173852
#> 8093 1173853
#> 8094 1174028
#> 8095 1174035
#> 8096 1174039
#> 8097 1174044
#> 8098 1174092
#> 8099 1174093
#> 8100 1174232
#> 8101 1174243
#> 8102 1174328
#> 8103 1174348
#> 8104 1174352
#> 8105 1174358
#> 8106 1174359
#> 8107 1174362
#> 8108 1174365
#> 8109 1174408
#> 8110 1174412
#> 8111 1174413
#> 8112 1174414
#> 8113 1174415
#> 8114 1174416
#> 8115 1174417
#> 8116 1174418
#> 8117 1174419
#> 8118 1174420
#> 8119 1174421
#> 8120 1174422
#> 8121 1174423
#> 8122 1174424
#> 8123 1174425
#> 8124 1174426
#> 8125 1174427
#> 8126 1174428
#> 8127 1174429
#> 8128 1174430
#> 8129 1174431
#> 8130 1174432
#> 8131 1174433
#> 8132 1174434
#> 8133 1174435
#> 8134 1174436
#> 8135 1174437
#> 8136 1174438
#> 8137 1174439
#> 8138 1174440
#> 8139 1174441
#> 8140 1174442
#> 8141 1174443
#> 8142 1174447
#> 8143 1174448
#> 8144 1174449
#> 8145 1174450
#> 8146 1174451
#> 8147 1174452
#> 8148 1174453
#> 8149 1174454
#> 8150 1174455
#> 8151 1174457
#> 8152 1174459
#> 8153 1174680
#> 8154 1174856
#> 8155 1174881
#> 8156 1174888
#> 8157 1174889
#> 8158 1174890
#> 8159 1174891
#> 8160 1174892
#> 8161 1175223
#> 8162 1175263
#> 8163 1175264
#> 8164 1175265
#> 8165 1175266
#> 8166 1175267
#> 8167 1175268
#> 8168 1175269
#> 8169 1175270
#> 8170 1175271
#> 8171 1175272
#> 8172 1175302
#> 8173 1175308
#> 8174 1175309
#> 8175 1175310
#> 8176 1175311
#> 8177 1175516
#> 8178 1175674
#> 8179 1175683
#> 8180 1175734
#> 8181 1175817
#> 8182 1176274
#> 8183 1176707
#> 8184 1176851
#> 8185 1177039
#> 8186 1177406
#> 8187 1177553
#> 8188 1177583
#> 8189 1177679
#> 8190 1177682
#> 8191 1177686
#> 8192 1177689
#> 8193 1177692
#> 8194 1177695
#> 8195 1177704
#> 8196 1177705
#> 8197 1177706
#> 8198 1177707
#> 8199 1177711
#> 8200 1177713
#> 8201 1177715
#> 8202 1177761
#> 8203 1177762
#> 8204 1177763
#> 8205 1177764
#> 8206 1177765
#> 8207 1177766
#> 8208 1177771
#> 8209 1177772
#> 8210 1177773
#> 8211 1177774
#> 8212 1177775
#> 8213 1177776
#> 8214 1177777
#> 8215 1177778
#> 8216 1177795
#> 8217 1177796
#> 8218 1178004
#> 8219 1178045
#> 8220 1178049
#> 8221 1178062
#> 8222 1178133
#> 8223 1178335
#> 8224 1178336
#> 8225 1178407
#> 8226 1179244
#> 8227 1179245
#> 8228 1179246
#> 8229 1179247
#> 8230 1179248
#> 8231 1179253
#> 8232 1179387
#> 8233 1179390
#> 8234 1179397
#> 8235 1179567
#> 8236 1179980
#> 8237 1180155
#> 8238 1180307
#> 8239 1180327
#> 8240 1180383
#> 8241 1180385
#> 8242 1180386
#> 8243 1180387
#> 8244 1180388
#> 8245 1180389
#> 8246 1180503
#> 8247 1180504
#> 8248 1180505
#> 8249 1180516
#> 8250 1180517
#> 8251 1180518
#> 8252 1180519
#> 8253 1181211
#> 8254 1181406
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#> 8256 1181410
#> 8257 1181690
#> 8258 1181691
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#> 8260 1181760
#> 8261 1181783
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#> 8263 1181986
#> 8264 1181987
#> 8265 1181988
#> 8266 1181989
#> 8267 1181990
#> 8268 1181991
#> 8269 1181992
#> 8270 1181993
#> 8271 1181994
#> 8272 1181995
#> 8273 1182325
#> 8274 1182419
#> 8275 1183479
#> 8276 1183657
#> 8277 1183669
#> 8278 1183670
#> 8279 1183673
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#> 8281 1183677
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#> 8286 1183682
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#> 8292 1183690
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#> 8295 1183710
#> 8296 1183719
#> 8297 1183720
#> 8298 1183721
#> 8299 1183722
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#> 8301 1183724
#> 8302 1183725
#> 8303 1183726
#> 8304 1183727
#> 8305 1183728
#> 8306 1183729
#> 8307 1183730
#> 8308 1183731
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#> 8310 1183864
#> 8311 1183865
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#> 8313 1183867
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#> 8315 1183869
#> 8316 1183870
#> 8317 1183871
#> 8318 1183876
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#> 8320 1183892
#> 8321 1183894
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#> 8323 1183898
#> 8324 1183900
#> 8325 1183902
#> 8326 1183904
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#> 8328 1184080
#> 8329 1184086
#> 8330 1184087
#> 8331 1184379
#> 8332 1184380
#> 8333 1184650
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#> 8337 1185180
#> 8338 1185196
#> 8339 1185197
#> 8340 1185198
#> 8341 1185199
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#> 8346 1185209
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#> 8348 1185211
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#> 8350 1185213
#> 8351 1185214
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#> 8353 1185216
#> 8354 1185217
#> 8355 1185218
#> 8356 1185219
#> 8357 1185220
#> 8358 1185221
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#> 8360 1185223
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#> 8362 1185225
#> 8363 1185226
#> 8364 1185227
#> 8365 1185228
#> 8366 1185229
#> 8367 1185230
#> 8368 1185231
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#> 8370 1185253
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#> 8372 1185391
#> 8373 1185634
#> 8374 1185635
#> 8375 1185639
#> 8376 1185642
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#> 8380 1185647
#> 8381 1185649
#> 8382 1185725
#> 8383 1185744
#> 8384 1185770
#> 8385 1185874
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#> 8387 1185876
#> 8388 1185877
#> 8389 1186218
#> 8390 1186251
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#> 8392 1186447
#> 8393 1186701
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#> 8395 1187160
#> 8396 1187258
#> 8397 1187288
#> 8398 1187627
#> 8399 1187628
#> 8400 1187995
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#> 8402 1188222
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#> 8404 1188225
#> 8405 1188226
#> 8406 1188360
#> 8407 1188622
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#> 8409 1188900
#> 8410 1188901
#> 8411 1188904
#> 8412 1188905
#> 8413 1189503
#> 8414 1189580
#> 8415 1189830
#> 8416 1189831
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#> 8418 1189833
#> 8419 1189834
#> 8420 1189835
#> 8421 1190070
#> 8422 1190324
#> 8423 1190329
#> 8424 1190330
#> 8425 1190331
#> 8426 1190388
#> 8427 1190569
#> 8428 1190570
#> 8429 1190571
#> 8430 1190572
#> 8431 1190619
#> 8432 1191020
#> 8433 1191357
#> 8434 1191361
#> 8435 1191362
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#> 8437 1191364
#> 8438 1191365
#> 8439 1191366
#> 8440 1191367
#> 8441 1191368
#> 8442 1191479
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#> 8446 1191584
#> 8447 1191758
#> 8448 1191761
#> 8449 1191762
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#> 8451 1191766
#> 8452 1191973
#> 8453 1191974
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#> 8455 1192348
#> 8456 1192349
#> 8457 1192780
#> 8458 1193483
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#> 8460 1193580
#> 8461 1193581
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#> 8465 1193587
#> 8466 1193588
#> 8467 1193589
#> 8468 1193590
#> 8469 1193591
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#> 8471 1193593
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#> 8473 1193595
#> 8474 1193596
#> 8475 1193597
#> 8476 1193598
#> 8477 1193599
#> 8478 1193600
#> 8479 1193601
#> 8480 1193602
#> 8481 1193603
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#> 8483 1193605
#> 8484 1193610
#> 8485 1193611
#> 8486 1193877
#> 8487 1194053
#> 8488 1194235
#> 8489 1194236
#> 8490 1194237
#> 8491 1194238
#> 8492 1194548
#> 8493 1194579
#> 8494 1194693
#> 8495 1194980
#> 8496 1195064
#> 8497 1195291
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#> 8499 1195293
#> 8500 1196125
#> 8501 1196126
#> 8502 1196127
#> 8503 1196128
#> 8504 1196129
#> 8505 1196130
#> 8506 1196131
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#> 8508 1196133
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#> 8510 1196135
#> 8511 1196136
#> 8512 1196137
#> 8513 1196138
#> 8514 1196139
#> 8515 1196140
#> 8516 1196141
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#> 8518 1196143
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#> 8520 1196145
#> 8521 1196146
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#> 8525 1196150
#> 8526 1196151
#> 8527 1196152
#> 8528 1196220
#> 8529 1196221
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#> 8531 1196812
#> 8532 1197174
#> 8533 1197332
#> 8534 1197336
#> 8535 1197337
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#> 8537 1197339
#> 8538 1197372
#> 8539 1197580
#> 8540 1197616
#> 8541 1197838
#> 8542 1197866
#> 8543 1197867
#> 8544 1198076
#> 8545 1198102
#> 8546 1198352
#> 8547 1198356
#> 8548 1198369
#> 8549 1198377
#> 8550 1198471
#> 8551 1198933
#> 8552 1198934
#> 8553 1198938
#> 8554 1198939
#> 8555 1198997
#> 8556 1199173
#> 8557 1199266
#> 8558 1199596
#> 8559 1199602
#> 8560 1199604
#> 8561 1199611
#> 8562 1199612
#> 8563 1199613
#> 8564 1199614
#> 8565 1199615
#> 8566 1199616
#> 8567 1199617
#> 8568 1199618
#> 8569 1199619
#> 8570 1199620
#> 8571 1199621
#> 8572 1199622
#> 8573 1199623
#> 8574 1199624
#> 8575 1200154
#> 8576 1200155
#> 8577 1200309
#> 8578 1200491
#> 8579 1200781
#> 8580 1200977
#> 8581 1200978
#> 8582 1200979
#> 8583 1201099
#> 8584 1201102
#> 8585 1201124
#> 8586 1201128
#> 8587 1201130
#> 8588 1201131
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#> 8590 1201133
#> 8591 1201134
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#> 8593 1201136
#> 8594 1201137
#> 8595 1201138
#> 8596 1201139
#> 8597 1201140
#> 8598 1201141
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#> 8600 1201143
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#> 8602 1201145
#> 8603 1201146
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#> 8605 1201486
#> 8606 1201488
#> 8607 1201775
#> 8608 1201777
#> 8609 1201778
#> 8610 1201779
#> 8611 1201780
#> 8612 1201781
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#> 8614 1201783
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#> 8616 1201785
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#> 8619 1201788
#> 8620 1201789
#> 8621 1201790
#> 8622 1201791
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#> 8625 1201794
#> 8626 1201809
#> 8627 1201810
#> 8628 1202447
#> 8629 1202459
#> 8630 1202462
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#> 8632 1202593
#> 8633 1202594
#> 8634 1202760
#> 8635 1202850
#> 8636 1203635
#> 8637 1203683
#> 8638 1204007
#> 8639 1204112
#> 8640 1204113
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#> 8642 1204115
#> 8643 1204116
#> 8644 1204118
#> 8645 1204122
#> 8646 1204143
#> 8647 1204783
#> 8648 1204789
#> 8649 1204876
#> 8650 1205076
#> 8651 1205244
#> 8652 1205267
#> 8653 1205268
#> 8654 1205270
#> 8655 1205274
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#> 8657 1205302
#> 8658 1205507
#> 8659 1205520
#> 8660 1205522
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#> 8662 1205524
#> 8663 1205525
#> 8664 1205526
#> 8665 1205527
#> 8666 1205528
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#> 8668 1205530
#> 8669 1205531
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#> 8671 1205533
#> 8672 1205534
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#> 8674 1205536
#> 8675 1205537
#> 8676 1205538
#> 8677 1205539
#> 8678 1205540
#> 8679 1205541
#> 8680 1205625
#> 8681 1205812
#> 8682 1205987
#> 8683 1205989
#> 8684 1205992
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#> 8686 1205994
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#> 8688 1205996
#> 8689 1205997
#> 8690 1205998
#> 8691 1205999
#> 8692 1206000
#> 8693 1206001
#> 8694 1206002
#> 8695 1206003
#> 8696 1206004
#> 8697 1206005
#> 8698 1206008
#> 8699 1206009
#> 8700 1206010
#> 8701 1206011
#> 8702 1206012
#> 8703 1206013
#> 8704 1206270
#> 8705 1206542
#> 8706 1206546
#> 8707 1206736
#> 8708 1206739
#> 8709 1206848
#> 8710 1206852
#> 8711 1207077
#> 8712 1207118
#> 8713 1210090
#> 8714 1210091
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#> 8720 1210097
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#> 8723 1210100
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#> 8725 1210102
#> 8726 1210103
#> 8727 1220208
#> 8728 1220348
#> 8729 1222593
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#> 8731 1223765
#> 8732 1224561
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#> 8734 1225506
#> 8735 1225970
#> 8736 1226601
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#> 8738 1226622
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#> 8749 1226837
#> 8750 1226842
#> 8751 1226843
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#> 8753 1226849
#> 8754 1227342
#> 8755 1227343
#> 8756 1227361
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#> 8758 1227890
#> 8759 1227892
#> 8760 1227903
#> 8761 1227904
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#> 8763 1227908
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#> 8767 1227916
#> 8768 1227919
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#> 8770 1227923
#> 8771 1227925
#> 8772 1227927
#> 8773 1227998
#> 8774 1228040
#> 8775 1228042
#> 8776 1228044
#> 8777 1228395
#> 8778 1228397
#> 8779 1228630
#> 8780 1228674
#> 8781 1228715
#> 8782 1228719
#> 8783 1228826
#> 8784 1228829
#> 8785 1229553
#> 8786 1229554
#> 8787 1229734
#> 8788 1229764
#> 8789 1230109
#> 8790 1230110
#> 8791 1230122
#> 8792 1230126
#> 8793 1231287
#> 8794 1231350
#> 8795 1231682
#> 8796 1232292
#> 8797 1232938
#> 8798 1232939
#> 8799 1232940
#> 8800 1232941
#> 8801 1232942
#> 8802 1232943
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#> 8804 1232945
#> 8805 1233071
#> 8806 1233077
#> 8807 1233369
#> 8808 1233443
#> 8809 1233502
#> 8810 1234344
#> 8811 1234345
#> 8812 1234346
#> 8813 1234347
#> 8814 1234348
#> 8815 1234349
#> 8816 1234350
#> 8817 1234804
#> 8818 1234842
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#> 8830 1235221
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#> 8833 1235827
#> 8834 1235831
#> 8835 1235842
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#> 8837 1236350
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#> 8857 1236375
#> 8858 1236376
#> 8859 1236377
#> 8860 1236522
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#> 8862 1236524
#> 8863 1236525
#> 8864 1236527
#> 8865 1236528
#> 8866 1236529
#> 8867 1236530
#> 8868 1236531
#> 8869 1236532
#> 8870 1236533
#> 8871 1236562
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#> 8874 1236565
#> 8875 1236568
#> 8876 1236707
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#> 8878 1236738
#> 8879 1236739
#> 8880 1236740
#> 8881 1236753
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#> 8883 1236755
#> 8884 1236765
#> 8885 1236766
#> 8886 1236767
#> 8887 1236774
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#> 8889 1236880
#> 8890 1236897
#> 8891 1237468
#> 8892 1237472
#> 8893 1237721
#> 8894 1237722
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#> 8896 1237728
#> 8897 1237729
#> 8898 1237730
#> 8899 1237731
#> 8900 1237732
#> 8901 1237733
#> 8902 1237753
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#> 8904 1237755
#> 8905 1237756
#> 8906 1237757
#> 8907 1237758
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#> 8909 1237760
#> 8910 1237761
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#> 8912 1237763
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#> 8914 1237765
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#> 8916 1237767
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#> 8918 1238085
#> 8919 1238086
#> 8920 1238089
#> 8921 1238160
#> 8922 1238161
#> 8923 1238353
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#> 8925 1238925
#> 8926 1238946
#> 8927 1238947
#> 8928 1239031
#> 8929 1239037
#> 8930 1239038
#> 8931 1239039
#> 8932 1239295
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#> 8935 1240075
#> 8936 1240087
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#> 8948 1240200
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#> 8951 1240203
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#> 8955 1240207
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#> 8957 1240272
#> 8958 1240548
#> 8959 1240612
#> 8960 1241050
#> 8961 1241074
#> 8962 1241183
#> 8963 1241333
#> 8964 1241935
#> 8965 1242057
#> 8966 1242167
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#> 8968 1242172
#> 8969 1242181
#> 8970 1242182
#> 8971 1242783
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#> 8973 1243496
#> 8974 1243515
#> 8975 1244026
#> 8976 1244032
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#> 8978 1244056
#> 8979 1244065
#> 8980 1244080
#> 8981 1244243
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#> 8983 1244245
#> 8984 1244247
#> 8985 1244348
#> 8986 1244542
#> 8987 1244623
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#> 8989 1245175
#> 8990 1245176
#> 8991 1245507
#> 8992 1245508
#> 8993 1245509
#> 8994 1245510
#> 8995 1245511
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#> 8997 1245513
#> 8998 1245514
#> 8999 1245515
#> 9000 1245516
#> 9001 1245517
#> 9002 1245518
#> 9003 1245527
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#> 9005 1245531
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#> 9007 1245535
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#> 9009 1245537
#> 9010 1245538
#> 9011 1245539
#> 9012 1245540
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#> 9015 1245543
#> 9016 1245544
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#> 9018 1245546
#> 9019 1245547
#> 9020 1245548
#> 9021 1245549
#> 9022 1245550
#> 9023 1245551
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#> 9025 1245681
#> 9026 1245689
#> 9027 1245746
#> 9028 1246953
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#> 9030 1247182
#> 9031 1247187
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#> 9033 1247278
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#> 9035 1247850
#> 9036 1247851
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#> 9038 1247853
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#> 9040 1247855
#> 9041 1247856
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#> 9043 1247858
#> 9044 1247859
#> 9045 1247860
#> 9046 1247879
#> 9047 1248171
#> 9048 1248355
#> 9049 1248356
#> 9050 1248445
#> 9051 1248479
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#> 9053 1248487
#> 9054 1248498
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#> 9057 1249220
#> 9058 1249630
#> 9059 1249634
#> 9060 1249635
#> 9061 1249636
#> 9062 1249637
#> 9063 1250362
#> 9064 1250462
#> 9065 1250717
#> 9066 1250724
#> 9067 1250814
#> 9068 1250817
#> 9069 1250820
#> 9070 1250823
#> 9071 1250826
#> 9072 1250829
#> 9073 1251003
#> 9074 1251056
#> 9075 1251857
#> 9076 1251860
#> 9077 1251861
#> 9078 1251864
#> 9079 1251865
#> 9080 1251866
#> 9081 1251867
#> 9082 1251868
#> 9083 1251869
#> 9084 1251933
#> 9085 1251952
#> 9086 1252388
#> 9087 1252410
#> 9088 1252468
#> 9089 1252547
#> 9090 1252726
#> 9091 1252729
#> 9092 1252730
#> 9093 1252740
#> 9094 1252743
#> 9095 1252744
#> 9096 1252745
#> 9097 1252746
#> 9098 1253103
#> 9099 1253147
#> 9100 1253148
#> 9101 1253149
#> 9102 1253150
#> 9103 1253151
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#> 9105 1253153
#> 9106 1253864
#> 9107 1253987
#> 9108 1253993
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#> 9110 1253995
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#> 9113 1253998
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#> 9115 1254000
#> 9116 1254001
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#> 9118 1254003
#> 9119 1254004
#> 9120 1254263
#> 9121 1254406
#> 9122 1254638
#> 9123 1254677
#> 9124 1254681
#> 9125 1254686
#> 9126 1254817
#> 9127 1255082
#> 9128 1255282
#> 9129 1255283
#> 9130 1255299
#> 9131 1255300
#> 9132 1255301
#> 9133 1255360
#> 9134 1255388
#> 9135 1256443
#> 9136 1256522
#> 9137 1256785
#> 9138 1257013
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#> 9140 1259755
#> 9141 1259927
#> 9142 1259935
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#> 9152 1261187
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#> 9154 1261189
#> 9155 1261462
#> 9156 1261463
#> 9157 1261470
#> 9158 1261471
#> 9159 1261472
#> 9160 1261641
#> 9161 1261642
#> 9162 1263005
#> 9163 1263291
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#> 9326 1271582
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#> 9328 1272010
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#> 9330 1272242
#> 9331 1272820
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#> 9373 1276458
#> 9374 1276751
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#> 9380 1277317
#> 9381 1277318
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#> 9396 1277801
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#> 9399 1278365
#> 9400 1278366
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#> 9407 1280151
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#> 9415 1280273
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#> 9418 1280422
#> 9419 1280423
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#> 9421 1281441
#> 9422 1281444
#> 9423 1281447
#> 9424 1281452
#> 9425 1281453
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#> 9427 1281455
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#> 9429 1281464
#> 9430 1281467
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#> 9432 1281473
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#> 9434 1281480
#> 9435 1281481
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#> 9437 1281489
#> 9438 1281492
#> 9439 1281495
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#> 9441 1281501
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#> 9446 1281512
#> 9447 1281518
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#> 9451 1281814
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#> 9456 1282156
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#> 9458 1282211
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#> 9460 1282227
#> 9461 1282234
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#> 9464 1282329
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#> 9470 1282349
#> 9471 1282350
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#> 9476 1282355
#> 9477 1282356
#> 9478 1282357
#> 9479 1282358
#> 9480 1282359
#> 9481 1282471
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#> 9483 1282563
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#> 9485 1282566
#> 9486 1282567
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#> 9488 1283925
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#> 9490 1283938
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#> 9499 1284014
#> 9500 1284126
#> 9501 1285133
#> 9502 1285262
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#> 9512 1285920
#> 9513 1286126
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#> 9519 1287386
#> 9520 1287504
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#> 9523 1287881
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#> 9526 1287981
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#> 9530 1288233
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#> 9532 1289293
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#> 9534 1289360
#> 9535 1289382
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#> 9540 1290881
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#> 9642 1297978
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#> 9647 1298858
#> 9648 1298859
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#> 9650 1299475
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#> 9668 1299921
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#> 9671 1299924
#> 9672 1299925
#> 9673 1299926
#> 9674 1299927
#> 9675 1299928
#> 9676 1300618
#> 9677 1300660
#> 9678 1300664
#> 9679 1300669
#> 9680 1300674
#> 9681 1300820
#> 9682 1301248
#> 9683 1301417
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#> 9685 1304053
#> 9686 1304055
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#> 9689 1304182
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#> 9692 1304342
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#> 9694 1304391
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#> 9699 1304535
#> 9700 1304536
#> 9701 1304537
#> 9702 1304582
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#> 9704 1304840
#> 9705 1304841
#> 9706 1305660
#> 9707 1306333
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#> 9710 1306910
#> 9711 1307274
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#> 9771 1311624
#> 9772 1311625
#> 9773 1311626
#> 9774 1311627
#> 9775 1311628
#> 9776 1311629
#> 9777 1311630
#> 9778 1311631
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#> 9780 1311633
#> 9781 1311634
#> 9782 1311635
#> 9783 1311636
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#> 9785 1311638
#> 9786 1311639
#> 9787 1311640
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#> 9793 1311646
#> 9794 1311647
#> 9795 1311648
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#> 9798 1311651
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#> 9800 1311709
#> 9801 1311797
#> 9802 1311798
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#> 9804 1311802
#> 9805 1312042
#> 9806 1312340
#> 9807 1312341
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#> 9809 1312343
#> 9810 1312344
#> 9811 1312345
#> 9812 1312404
#> 9813 1312408
#> 9814 1312623
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#> 9816 1312642
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#> 9821 1312867
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#> 9854 1315445
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#> 9859 1315692
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#> 9871 1318682
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#> 9873 1318859
#> 9874 1318863
#> 9875 1319401
#> 9876 1320554
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#> 9878 1320556
#> 9879 1320951
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#> 9881 1321024
#> 9882 1321516
#> 9883 1321619
#> 9884 1322187
#> 9885 1322192
#> 9886 1322193
#> 9887 1322665
#> 9888 1322669
#> 9889 1322672
#> 9890 1322673
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#> 9892 1322675
#> 9893 1322679
#> 9894 1322680
#> 9895 1322681
#> 9896 1322682
#> 9897 1323194
#> 9898 1323224
#> 9899 1323226
#> 9900 1323272
#> 9901 1323394
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#> 9903 1324282
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#> 9905 1324290
#> 9906 1324332
#> 9907 1324367
#> 9908 1324383
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#> 9910 1324674
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#> 9912 1324691
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#> 9922 1326613
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#> 9940 1326788
#> 9941 1326789
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#> 9960 1328345
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#> 9966 1329678
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#> 9976 1329773
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#> 9978 1330282
#> 9979 1330679
#> 9980 1330717
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#> 9983 1331138
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#> 9986 1331141
#> 9987 1331146
#> 9988 1331147
#> 9989 1331195
#> 9990 1331196
#> 9991 1331683
#> 9992 1331866
#> 9993 1331921
#> 9994 1332066
#> 9995 1332137
#> 9996 1332221
#> 9997 1332222
#> 9998 1332272
#> 9999 1332469
#> 10000 1332474
#> 10001 1332889
#> 10002 1332890
#> 10003 1332891
#> 10004 1333345
#> 10005 1333369
#> 10006 1333401
#> 10007 1333403
#> 10008 1333404
#> 10009 1333405
#> 10010 1333406
#> 10011 1333407
#> 10012 1333408
#> 10013 1333409
#> 10014 1333410
#> 10015 1333411
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#> 10017 1333413
#> 10018 1333414
#> 10019 1333415
#> 10020 1333416
#> 10021 1333417
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#> 10023 1333419
#> 10024 1333783
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#> 10026 1333796
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#> 10029 1333799
#> 10030 1333800
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#> 10032 1333802
#> 10033 1333803
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#> 10035 1333805
#> 10036 1333875
#> 10037 1334988
#> 10038 1335229
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#> 10040 1335253
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#> 10042 1335572
#> 10043 1335671
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#> 10060 1337672
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#> 10063 1337860
#> 10064 1337861
#> 10065 1337872
#> 10066 1337873
#> 10067 1337875
#> 10068 1337884
#> 10069 1337885
#> 10070 1337886
#> 10071 1337887
#> 10072 1338079
#> 10073 1338408
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#> 10075 1338420
#> 10076 1338424
#> 10077 1338425
#> 10078 1338426
#> 10079 1338429
#> 10080 1338430
#> 10081 1338431
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#> 10083 1338433
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#> 10086 1338436
#> 10087 1338437
#> 10088 1338438
#> 10089 1338439
#> 10090 1338505
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#> 10092 1338512
#> 10093 1338515
#> 10094 1338516
#> 10095 1338517
#> 10096 1338518
#> 10097 1338536
#> 10098 1339746
#> 10099 1339748
#> 10100 1339749
#> 10101 1339750
#> 10102 1339751
#> 10103 1339796
#> 10104 1340386
#> 10105 1340484
#> 10106 1340485
#> 10107 1340486
#> 10108 1340600
#> 10109 1340607
#> 10110 1340608
#> 10111 1340609
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#> 10115 1340800
#> 10116 1340801
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#> 10118 1341033
#> 10119 1341034
#> 10120 1341035
#> 10121 1341222
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#> 10123 1341224
#> 10124 1341225
#> 10125 1341226
#> 10126 1341227
#> 10127 1341854
#> 10128 1341855
#> 10129 1341856
#> 10130 1342578
#> 10131 1347605
#> 10132 1347686
#> 10133 1347691
#> 10134 1347717
#> 10135 1347948
#> 10136 1347989
#> 10137 1348020
#> 10138 1348283
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#> 10140 1348297
#> 10141 1348298
#> 10142 1348299
#> 10143 1348300
#> 10144 1348302
#> 10145 1348304
#> 10146 1348305
#> 10147 1348306
#> 10148 1348307
#> 10149 1348308
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#> 10151 1348678
#> 10152 1348796
#> 10153 1348858
#> 10154 1349059
#> 10155 1349060
#> 10156 1349922
#> 10157 1351371
#> 10158 1351509
#> 10159 1351553
#> 10160 1351590
#> 10161 1351597
#> 10162 1351601
#> 10163 1351625
#> 10164 1351630
#> 10165 1351636
#> 10166 1351642
#> 10167 1351648
#> 10168 1351722
#> 10169 1352042
#> 10170 1352048
#> 10171 1352049
#> 10172 1352050
#> 10173 1352051
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#> 10175 1352053
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#> 10178 1352056
#> 10179 1352057
#> 10180 1352058
#> 10181 1352102
#> 10182 1352354
#> 10183 1352791
#> 10184 1352854
#> 10185 1353321
#> 10186 1353602
#> 10187 1353607
#> 10188 1353631
#> 10189 1353903
#> 10190 1353904
#> 10191 1353907
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#> 10193 1353914
#> 10194 1353915
#> 10195 1353916
#> 10196 1353917
#> 10197 1353918
#> 10198 1353919
#> 10199 1353920
#> 10200 1353922
#> 10201 1353923
#> 10202 1353926
#> 10203 1353932
#> 10204 1353933
#> 10205 1353934
#> 10206 1353935
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#> 10208 1353937
#> 10209 1353938
#> 10210 1353939
#> 10211 1353940
#> 10212 1353941
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#> 10215 1353944
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#> 10217 1353946
#> 10218 1353947
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#> 10220 1353949
#> 10221 1353950
#> 10222 1354765
#> 10223 1354808
#> 10224 1355086
#> 10225 1355122
#> 10226 1355749
#> 10227 1355753
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#> 10229 1357153
#> 10230 1357525
#> 10231 1358237
#> 10232 1358238
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#> 10234 1359157
#> 10235 1359162
#> 10236 1359163
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#> 10238 1359167
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#> 10240 1359169
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#> 10242 1359458
#> 10243 1359775
#> 10244 1360199
#> 10245 1360407
#> 10246 1360488
#> 10247 1360491
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#> 10249 1360493
#> 10250 1360494
#> 10251 1360519
#> 10252 1360520
#> 10253 1360701
#> 10254 1360878
#> 10255 1360894
#> 10256 1361024
#> 10257 1361032
#> 10258 1361034
#> 10259 1361052
#> 10260 1362219
#> 10261 1362220
#> 10262 1362221
#> 10263 1362222
#> 10264 1362223
#> 10265 1362224
#> 10266 1362225
#> 10267 1362226
#> 10268 1362227
#> 10269 1362236
#> 10270 1362238
#> 10271 1362239
#> 10272 1362240
#> 10273 1362595
#> 10274 1362924
#> 10275 1363195
#> 10276 1364316
#> 10277 1364641
#> 10278 1364647
#> 10279 1364648
#> 10280 1364649
#> 10281 1364866
#> 10282 1364867
#> 10283 1364868
#> 10284 1364869
#> 10285 1364870
#> 10286 1364871
#> 10287 1364872
#> 10288 1364873
#> 10289 1364874
#> 10290 1364875
#> 10291 1364876
#> 10292 1364877
#> 10293 1364878
#> 10294 1364879
#> 10295 1364880
#> 10296 1364881
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#> 10298 1364883
#> 10299 1364884
#> 10300 1364885
#> 10301 1364886
#> 10302 1364887
#> 10303 1364888
#> 10304 1364889
#> 10305 1364890
#> 10306 1364891
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#> 10308 1364893
#> 10309 1364894
#> 10310 1364895
#> 10311 1364896
#> 10312 1364897
#> 10313 1364898
#> 10314 1364899
#> 10315 1365175
#> 10316 1365617
#> 10317 1366709
#> 10318 1366860
#> 10319 1367200
#> 10320 1367219
#> 10321 1367220
#> 10322 1367600
#> 10323 1367971
#> 10324 1367972
#> 10325 1367983
#> 10326 1367984
#> 10327 1367985
#> 10328 1367986
#> 10329 1367987
#> 10330 1367988
#> 10331 1367989
#> 10332 1367990
#> 10333 1367991
#> 10334 1367992
#> 10335 1367993
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#> 10337 1367995
#> 10338 1367996
#> 10339 1367997
#> 10340 1367998
#> 10341 1368004
#> 10342 1368005
#> 10343 1368088
#> 10344 1368237
#> 10345 1368238
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#> 10347 1368240
#> 10348 1368241
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#> 10350 1368243
#> 10351 1368244
#> 10352 1368245
#> 10353 1368246
#> 10354 1368247
#> 10355 1368248
#> 10356 1368259
#> 10357 1368262
#> 10358 1368263
#> 10359 1368264
#> 10360 1368265
#> 10361 1368910
#> 10362 1369036
#> 10363 1369037
#> 10364 1369038
#> 10365 1369039
#> 10366 1369048
#> 10367 1369290
#> 10368 1370138
#> 10369 1370140
#> 10370 1370142
#> 10371 1370144
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#> 10373 1370150
#> 10374 1370151
#> 10375 1370152
#> 10376 1370154
#> 10377 1370156
#> 10378 1370158
#> 10379 1370160
#> 10380 1370162
#> 10381 1370164
#> 10382 1370165
#> 10383 1370174
#> 10384 1370443
#> 10385 1370608
#> 10386 1370809
#> 10387 1370848
#> 10388 1371027
#> 10389 1371331
#> 10390 1371473
#> 10391 1372078
#> 10392 1372079
#> 10393 1372081
#> 10394 1372082
#> 10395 1372138
#> 10396 1372139
#> 10397 1372733
#> 10398 1372736
#> 10399 1372742
#> 10400 1373379
#> 10401 1373393
#> 10402 1373394
#> 10403 1373395
#> 10404 1373396
#> 10405 1373397
#> 10406 1373398
#> 10407 1373399
#> 10408 1373400
#> 10409 1373401
#> 10410 1373402
#> 10411 1374019
#> 10412 1374020
#> 10413 1374097
#> 10414 1374232
#> 10415 1374370
#> 10416 1374856
#> 10417 1374948
#> 10418 1375725
#> 10419 1376923
#> 10420 1376932
#> 10421 1376989
#> 10422 1377013
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#> 10424 1377086
#> 10425 1377167
#> 10426 1377480
#> 10427 1377489
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#> 10429 1377508
#> 10430 1378248
#> 10431 1378386
#> 10432 1378391
#> 10433 1378396
#> 10434 1378403
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#> 10436 1378623
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#> 10438 1378645
#> 10439 1379253
#> 10440 1379254
#> 10441 1379255
#> 10442 1379256
#> 10443 1379257
#> 10444 1379650
#> 10445 1379651
#> 10446 1379661
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#> 10448 1379664
#> 10449 1379665
#> 10450 1379666
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#> 10452 1379668
#> 10453 1379669
#> 10454 1379670
#> 10455 1379671
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#> 10457 1379673
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#> 10459 1379675
#> 10460 1379676
#> 10461 1379677
#> 10462 1379678
#> 10463 1379679
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#> 10465 1379681
#> 10466 1379682
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#> 10468 1379684
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#> 10470 1379686
#> 10471 1379687
#> 10472 1379688
#> 10473 1379689
#> 10474 1379690
#> 10475 1379691
#> 10476 1379692
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#> 10478 1379817
#> 10479 1379947
#> 10480 1379948
#> 10481 1379969
#> 10482 1379995
#> 10483 1380399
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#> 10487 1380407
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#> 10489 1380409
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#> 10497 1380417
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#> 10499 1380419
#> 10500 1380420
#> 10501 1380421
#> 10502 1380422
#> 10503 1380423
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#> 10505 1380425
#> 10506 1380426
#> 10507 1380427
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#> 10509 1380429
#> 10510 1380430
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#> 10530 1381047
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#> 10532 1381049
#> 10533 1381077
#> 10534 1381079
#> 10535 1381080
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#> 10556 1381582
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#> 10558 1381973
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#> 10560 1382444
#> 10561 1382446
#> 10562 1382639
#> 10563 1382776
#> 10564 1382780
#> 10565 1382783
#> 10566 1383307
#> 10567 1383993
#> 10568 1384133
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#> 10570 1384646
#> 10571 1384652
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#> 10573 1385099
#> 10574 1385454
#> 10575 1385700
#> 10576 1386263
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#> 10578 1386265
#> 10579 1386266
#> 10580 1386517
#> 10581 1386519
#> 10582 1386590
#> 10583 1387100
#> 10584 1387378
#> 10585 1387381
#> 10586 1388158
#> 10587 1388168
#> 10588 1388178
#> 10589 1388321
#> 10590 1388322
#> 10591 1388523
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#> 10593 1388625
#> 10594 1388626
#> 10595 1388627
#> 10596 1388628
#> 10597 1388631
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#> 10599 1388633
#> 10600 1388634
#> 10601 1388635
#> 10602 1388637
#> 10603 1388638
#> 10604 1388640
#> 10605 1388641
#> 10606 1388900
#> 10607 1389352
#> 10608 1389357
#> 10609 1390003
#> 10610 1390004
#> 10611 1390025
#> 10612 1390092
#> 10613 1390170
#> 10614 1390171
#> 10615 1390172
#> 10616 1390181
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#> 10619 1390186
#> 10620 1390189
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#> 10622 1390191
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#> 10624 1390197
#> 10625 1390219
#> 10626 1390384
#> 10627 1391248
#> 10628 1391396
#> 10629 1391397
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#> 10631 1392068
#> 10632 1392077
#> 10633 1392078
#> 10634 1392309
#> 10635 1392487
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#> 10637 1392528
#> 10638 1392529
#> 10639 1392530
#> 10640 1392531
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#> 10642 1392533
#> 10643 1392534
#> 10644 1392535
#> 10645 1392536
#> 10646 1392537
#> 10647 1392538
#> 10648 1392539
#> 10649 1392540
#> 10650 1392541
#> 10651 1392558
#> 10652 1393882
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#> 10654 1393888
#> 10655 1393889
#> 10656 1393890
#> 10657 1393897
#> 10658 1393898
#> 10659 1393903
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#> 10661 1394672
#> 10662 1394768
#> 10663 1395051
#> 10664 1395532
#> 10665 1395977
#> 10666 1397252
#> 10667 1397261
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#> 10669 1398042
#> 10670 1398044
#> 10671 1398045
#> 10672 1398046
#> 10673 1398047
#> 10674 1398048
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#> 10676 1398050
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#> 10679 1398053
#> 10680 1398054
#> 10681 1398055
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#> 10684 1398058
#> 10685 1398059
#> 10686 1398060
#> 10687 1398061
#> 10688 1398062
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#> 10690 1398064
#> 10691 1398065
#> 10692 1398066
#> 10693 1398067
#> 10694 1398068
#> 10695 1398069
#> 10696 1398070
#> 10697 1398071
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#> 10699 1398073
#> 10700 1398074
#> 10701 1398075
#> 10702 1398076
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#> 10704 1398078
#> 10705 1398079
#> 10706 1398080
#> 10707 1398081
#> 10708 1398082
#> 10709 1398083
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#> 10711 1398085
#> 10712 1398086
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#> 10714 1398088
#> 10715 1398089
#> 10716 1398090
#> 10717 1398091
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#> 10719 1398093
#> 10720 1398094
#> 10721 1398506
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#> 10723 1398508
#> 10724 1398515
#> 10725 1398516
#> 10726 1398547
#> 10727 1399019
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#> 10729 1399070
#> 10730 1399120
#> 10731 1399124
#> 10732 1399125
#> 10733 1399126
#> 10734 1399127
#> 10735 1399131
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#> 10737 1399307
#> 10738 1399377
#> 10739 1400211
#> 10740 1401533
#> 10741 1401723
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#> 10743 1401730
#> 10744 1401731
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#> 10746 1401733
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#> 10748 1401735
#> 10749 1401736
#> 10750 1401737
#> 10751 1401738
#> 10752 1401739
#> 10753 1401740
#> 10754 1401741
#> 10755 1401742
#> 10756 1401743
#> 10757 1401744
#> 10758 1401745
#> 10759 1401746
#> 10760 1401747
#> 10761 1401748
#> 10762 1401749
#> 10763 1401750
#> 10764 1401751
#> 10765 1401752
#> 10766 1401753
#> 10767 1401754
#> 10768 1401755
#> 10769 1401756
#> 10770 1401757
#> 10771 1401758
#> 10772 1401761
#> 10773 1401762
#> 10774 1401763
#> 10775 1401832
#> 10776 1401893
#> 10777 1401894
#> 10778 1401897
#> 10779 1402066
#> 10780 1402071
#> 10781 1402072
#> 10782 1402073
#> 10783 1402074
#> 10784 1402075
#> 10785 1402076
#> 10786 1402077
#> 10787 1402078
#> 10788 1402079
#> 10789 1402080
#> 10790 1402081
#> 10791 1402082
#> 10792 1402083
#> 10793 1402685
#> 10794 1402689
#> 10795 1402692
#> 10796 1402693
#> 10797 1402694
#> 10798 1402695
#> 10799 1402696
#> 10800 1402697
#> 10801 1402706
#> 10802 1402710
#> 10803 1402711
#> 10804 1402712
#> 10805 1402713
#> 10806 1402714
#> 10807 1402715
#> 10808 1402716
#> 10809 1402717
#> 10810 1402718
#> 10811 1402719
#> 10812 1402720
#> 10813 1402721
#> 10814 1402722
#> 10815 1402723
#> 10816 1402724
#> 10817 1402725
#> 10818 1402726
#> 10819 1402727
#> 10820 1402728
#> 10821 1402738
#> 10822 1402739
#> 10823 1402740
#> 10824 1402741
#> 10825 1402742
#> 10826 1402743
#> 10827 1402744
#> 10828 1402745
#> 10829 1402746
#> 10830 1402747
#> 10831 1402748
#> 10832 1402749
#> 10833 1402750
#> 10834 1402751
#> 10835 1402752
#> 10836 1402753
#> 10837 1402754
#> 10838 1402755
#> 10839 1402756
#> 10840 1402757
#> 10841 1402758
#> 10842 1402759
#> 10843 1402760
#> 10844 1402761
#> 10845 1402762
#> 10846 1402763
#> 10847 1402764
#> 10848 1402765
#> 10849 1402766
#> 10850 1402767
#> 10851 1402768
#> 10852 1402769
#> 10853 1402770
#> 10854 1402771
#> 10855 1402772
#> 10856 1402773
#> 10857 1402774
#> 10858 1402775
#> 10859 1402776
#> 10860 1402779
#> 10861 1402780
#> 10862 1402781
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#> 10864 1402783
#> 10865 1402784
#> 10866 1402785
#> 10867 1402786
#> 10868 1402796
#> 10869 1402797
#> 10870 1402821
#> 10871 1403375
#> 10872 1403414
#> 10873 1403522
#> 10874 1403593
#> 10875 1403603
#> 10876 1403604
#> 10877 1403605
#> 10878 1403606
#> 10879 1403608
#> 10880 1403609
#> 10881 1403610
#> 10882 1403611
#> 10883 1403612
#> 10884 1403613
#> 10885 1403614
#> 10886 1403615
#> 10887 1403616
#> 10888 1403617
#> 10889 1403618
#> 10890 1403619
#> 10891 1403620
#> 10892 1403621
#> 10893 1403622
#> 10894 1403623
#> 10895 1403720
#> 10896 1404169
#> 10897 1404298
#> 10898 1404315
#> 10899 1404316
#> 10900 1404317
#> 10901 1404318
#> 10902 1404319
#> 10903 1404320
#> 10904 1404321
#> 10905 1404322
#> 10906 1404323
#> 10907 1404324
#> 10908 1404325
#> 10909 1404326
#> 10910 1404333
#> 10911 1404334
#> 10912 1404335
#> 10913 1404336
#> 10914 1404337
#> 10915 1404338
#> 10916 1404353
#> 10917 1404433
#> 10918 1404445
#> 10919 1404461
#> 10920 1405369
#> 10921 1405430
#> 10922 1405707
#> 10923 1405708
#> 10924 1405709
#> 10925 1405710
#> 10926 1405711
#> 10927 1405713
#> 10928 1405714
#> 10929 1405715
#> 10930 1405716
#> 10931 1405717
#> 10932 1405752
#> 10933 1405765
#> 10934 1405794
#> 10935 1405797
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#> 10937 1405799
#> 10938 1405800
#> 10939 1405801
#> 10940 1405802
#> 10941 1405803
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#> 10943 1406014
#> 10944 1406347
#> 10945 1406350
#> 10946 1406352
#> 10947 1406353
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#> 10949 1406355
#> 10950 1406356
#> 10951 1406357
#> 10952 1406358
#> 10953 1406359
#> 10954 1406360
#> 10955 1406361
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#> 10957 1406363
#> 10958 1406364
#> 10959 1406365
#> 10960 1406366
#> 10961 1406382
#> 10962 1406384
#> 10963 1406385
#> 10964 1406386
#> 10965 1406387
#> 10966 1406388
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#> 10968 1406390
#> 10969 1406391
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#> 10971 1406393
#> 10972 1406394
#> 10973 1406395
#> 10974 1406396
#> 10975 1406397
#> 10976 1406398
#> 10977 1406399
#> 10978 1406400
#> 10979 1406401
#> 10980 1406402
#> 10981 1406403
#> 10982 1406424
#> 10983 1406425
#> 10984 1406426
#> 10985 1406427
#> 10986 1406439
#> 10987 1406440
#> 10988 1406448
#> 10989 1406449
#> 10990 1406450
#> 10991 1406451
#> 10992 1406452
#> 10993 1406453
#> 10994 1406756
#> 10995 1407255
#> 10996 1407710
#> 10997 1407799
#> 10998 1407806
#> 10999 1407984
#> 11000 1408114
#> 11001 1408253
#> 11002 1408719
#> 11003 1408884
#> 11004 1408885
#> 11005 1408886
#> 11006 1409116
#> 11007 1409117
#> 11008 1410218
#> 11009 1410219
#> 11010 1410220
#> 11011 1410221
#> 11012 1410222
#> 11013 1410223
#> 11014 1410224
#> 11015 1410339
#> 11016 1410420
#> 11017 1410421
#> 11018 1410422
#> 11019 1410910
#> 11020 1410911
#> 11021 1411801
#> 11022 1411921
#> 11023 1412411
#> 11024 1412412
#> 11025 1412413
#> 11026 1412784
#> 11027 1412954
#> 11028 1412961
#> 11029 1412980
#> 11030 1413230
#> 11031 1413820
#> 11032 1413965
#> 11033 1413966
#> 11034 1413967
#> 11035 1413971
#> 11036 1413972
#> 11037 1413973
#> 11038 1413974
#> 11039 1413975
#> 11040 1413976
#> 11041 1413977
#> 11042 1413978
#> 11043 1413979
#> 11044 1413980
#> 11045 1413981
#> 11046 1413982
#> 11047 1413984
#> 11048 1413985
#> 11049 1413986
#> 11050 1413987
#> 11051 1414210
#> 11052 1414639
#> 11053 1414891
#> 11054 1414901
#> 11055 1414902
#> 11056 1414903
#> 11057 1414911
#> 11058 1414919
#> 11059 1414920
#> 11060 1414921
#> 11061 1414922
#> 11062 1414925
#> 11063 1414940
#> 11064 1414941
#> 11065 1414942
#> 11066 1414943
#> 11067 1414944
#> 11068 1414945
#> 11069 1414949
#> 11070 1414950
#> 11071 1414951
#> 11072 1415413
#> 11073 1415416
#> 11074 1415417
#> 11075 1415418
#> 11076 1415422
#> 11077 1415423
#> 11078 1415424
#> 11079 1415425
#> 11080 1415426
#> 11081 1415850
#> 11082 1415899
#> 11083 1415903
#> 11084 1416464
#> 11085 1416608
#> 11086 1416609
#> 11087 1416610
#> 11088 1416611
#> 11089 1416612
#> 11090 1416615
#> 11091 1416616
#> 11092 1416617
#> 11093 1417204
#> 11094 1417227
#> 11095 1417228
#> 11096 1417229
#> 11097 1417232
#> 11098 1418228
#> 11099 1418252
#> 11100 1418543
#> 11101 1418549
#> 11102 1418901
#> 11103 1419064
#> 11104 1419065
#> 11105 1419067
#> 11106 1419072
#> 11107 1419073
#> 11108 1419723
#> 11109 1419744
#> 11110 1420819
#> 11111 1420984
#> 11112 1420995
#> 11113 1420997
#> 11114 1420998
#> 11115 1420999
#> 11116 1421000
#> 11117 1421001
#> 11118 1421002
#> 11119 1421003
#> 11120 1421004
#> 11121 1421005
#> 11122 1421006
#> 11123 1421007
#> 11124 1421008
#> 11125 1421009
#> 11126 1421010
#> 11127 1421011
#> 11128 1421012
#> 11129 1421014
#> 11130 1421015
#> 11131 1421016
#> 11132 1421017
#> 11133 1421018
#> 11134 1421019
#> 11135 1421020
#> 11136 1421021
#> 11137 1421022
#> 11138 1421023
#> 11139 1421025
#> 11140 1421026
#> 11141 1421027
#> 11142 1421028
#> 11143 1421029
#> 11144 1421030
#> 11145 1421031
#> 11146 1421032
#> 11147 1421033
#> 11148 1421034
#> 11149 1421035
#> 11150 1421036
#> 11151 1421037
#> 11152 1421038
#> 11153 1421039
#> 11154 1421040
#> 11155 1421041
#> 11156 1421042
#> 11157 1421043
#> 11158 1421044
#> 11159 1421045
#> 11160 1421046
#> 11161 1421047
#> 11162 1421048
#> 11163 1421049
#> 11164 1421050
#> 11165 1421051
#> 11166 1421052
#> 11167 1421053
#> 11168 1421054
#> 11169 1421055
#> 11170 1421056
#> 11171 1421057
#> 11172 1421058
#> 11173 1421059
#> 11174 1421060
#> 11175 1421061
#> 11176 1421062
#> 11177 1421063
#> 11178 1421064
#> 11179 1421065
#> 11180 1421066
#> 11181 1421067
#> 11182 1421068
#> 11183 1421069
#> 11184 1421070
#> 11185 1421071
#> 11186 1421072
#> 11187 1421073
#> 11188 1421074
#> 11189 1421075
#> 11190 1421076
#> 11191 1421077
#> 11192 1421078
#> 11193 1421079
#> 11194 1421080
#> 11195 1421380
#> 11196 1421534
#> 11197 1421548
#> 11198 1421562
#> 11199 1421777
#> 11200 1421778
#> 11201 1421781
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#> 11203 1421788
#> 11204 1421789
#> 11205 1421790
#> 11206 1421791
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#> 11208 1421793
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#> 11210 1421795
#> 11211 1421796
#> 11212 1421797
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#> 11214 1421799
#> 11215 1421800
#> 11216 1421801
#> 11217 1421802
#> 11218 1421803
#> 11219 1421804
#> 11220 1421805
#> 11221 1421806
#> 11222 1421807
#> 11223 1421808
#> 11224 1421809
#> 11225 1421810
#> 11226 1421811
#> 11227 1421812
#> 11228 1421813
#> 11229 1421814
#> 11230 1421815
#> 11231 1421816
#> 11232 1421817
#> 11233 1421818
#> 11234 1421819
#> 11235 1421820
#> 11236 1421821
#> 11237 1421822
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#> 11239 1421824
#> 11240 1421825
#> 11241 1421826
#> 11242 1422128
#> 11243 1422129
#> 11244 1422160
#> 11245 1422167
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#> 11247 1422178
#> 11248 1422555
#> 11249 1423054
#> 11250 1423202
#> 11251 1423225
#> 11252 1423345
#> 11253 1423376
#> 11254 1423377
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#> 11257 1423864
#> 11258 1423923
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#> 11260 1423974
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#> 11262 1424274
#> 11263 1424292
#> 11264 1424318
#> 11265 1424320
#> 11266 1424325
#> 11267 1424336
#> 11268 1424397
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#> 11270 1424446
#> 11271 1424526
#> 11272 1424527
#> 11273 1424529
#> 11274 1424556
#> 11275 1424557
#> 11276 1424752
#> 11277 1424794
#> 11278 1424795
#> 11279 1424796
#> 11280 1424797
#> 11281 1424798
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#> 11283 1424800
#> 11284 1424801
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#> 11286 1424803
#> 11287 1424804
#> 11288 1424805
#> 11289 1425604
#> 11290 1425606
#> 11291 1425747
#> 11292 1425750
#> 11293 1425751
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#> 11295 1425753
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#> 11298 1425756
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#> 11300 1425758
#> 11301 1425759
#> 11302 1425760
#> 11303 1425761
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#> 11305 1425763
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#> 11307 1425765
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#> 11309 1425767
#> 11310 1425768
#> 11311 1425769
#> 11312 1425780
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#> 11316 1425788
#> 11317 1425789
#> 11318 1425790
#> 11319 1425791
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#> 11322 1425794
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#> 11324 1425796
#> 11325 1425797
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#> 11328 1425800
#> 11329 1425801
#> 11330 1425802
#> 11331 1425803
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#> 11333 1425805
#> 11334 1425806
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#> 11336 1425808
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#> 11380 1427048
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#> 11392 1427157
#> 11393 1427840
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#> 11396 1428413
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#> 11398 1428611
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#> 11400 1430411
#> 11401 1430412
#> 11402 1430413
#> 11403 1430414
#> 11404 1430415
#> 11405 1430416
#> 11406 1430790
#> 11407 1430812
#> 11408 1431177
#> 11409 1431178
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#> 11411 1431446
#> 11412 1431683
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#> 11414 1431685
#> 11415 1431686
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#> 11418 1431689
#> 11419 1431690
#> 11420 1431694
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#> 11423 1431697
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#> 11425 1431699
#> 11426 1431700
#> 11427 1431701
#> 11428 1431702
#> 11429 1431703
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#> 11431 1431705
#> 11432 1431706
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#> 11434 1431708
#> 11435 1431709
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#> 11437 1431711
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#> 11439 1431713
#> 11440 1432181
#> 11441 1432394
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#> 11443 1432396
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#> 11451 1432407
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#> 11453 1432409
#> 11454 1432410
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#> 11457 1432413
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#> 11460 1432416
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#> 11462 1432418
#> 11463 1432419
#> 11464 1432420
#> 11465 1432421
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#> 11469 1432425
#> 11470 1432426
#> 11471 1432840
#> 11472 1432848
#> 11473 1432915
#> 11474 1433112
#> 11475 1433127
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#> 11477 1433129
#> 11478 1433132
#> 11479 1433140
#> 11480 1433141
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#> 11482 1433357
#> 11483 1433534
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#> 11485 1433538
#> 11486 1433539
#> 11487 1433540
#> 11488 1433541
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#> 11490 1433543
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#> 11493 1433546
#> 11494 1433547
#> 11495 1433548
#> 11496 1433549
#> 11497 1433550
#> 11498 1433551
#> 11499 1433552
#> 11500 1433553
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#> 11502 1433555
#> 11503 1433561
#> 11504 1433566
#> 11505 1433805
#> 11506 1433806
#> 11507 1434053
#> 11508 1434065
#> 11509 1434070
#> 11510 1434352
#> 11511 1434721
#> 11512 1434750
#> 11513 1435369
#> 11514 1435526
#> 11515 1435754
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#> 11517 1435760
#> 11518 1436220
#> 11519 1436221
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#> 11521 1436223
#> 11522 1436224
#> 11523 1436452
#> 11524 1437354
#> 11525 1437481
#> 11526 1437627
#> 11527 1438022
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#> 11529 1438384
#> 11530 1438530
#> 11531 1439164
#> 11532 1439165
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#> 11534 1439634
#> 11535 1439635
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#> 11537 1439637
#> 11538 1439638
#> 11539 1439639
#> 11540 1439640
#> 11541 1439641
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#> 11544 1439644
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#> 11546 1439646
#> 11547 1439647
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#> 11549 1439649
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#> 11551 1439929
#> 11552 1439935
#> 11553 1440198
#> 11554 1440652
#> 11555 1440659
#> 11556 1440664
#> 11557 1440671
#> 11558 1440696
#> 11559 1440700
#> 11560 1440703
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#> 11562 1440705
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#> 11564 1440713
#> 11565 1440714
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#> 11567 1440840
#> 11568 1441242
#> 11569 1441894
#> 11570 1442183
#> 11571 1443685
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#> 11573 1443690
#> 11574 1443691
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#> 11576 1443693
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#> 11578 1443695
#> 11579 1443696
#> 11580 1443697
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#> 11582 1443699
#> 11583 1443700
#> 11584 1443701
#> 11585 1443702
#> 11586 1443703
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#> 11588 1443705
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#> 11590 1443707
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#> 11592 1443709
#> 11593 1443710
#> 11594 1443711
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#> 11596 1443713
#> 11597 1443714
#> 11598 1443715
#> 11599 1444431
#> 11600 1444569
#> 11601 1444570
#> 11602 1444571
#> 11603 1444572
#> 11604 1444573
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#> 11606 1444575
#> 11607 1444576
#> 11608 1445115
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#> 11610 1445117
#> 11611 1445204
#> 11612 1445899
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#> 11614 1446632
#> 11615 1446864
#> 11616 1446868
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#> 11620 1448643
#> 11621 1448659
#> 11622 1448660
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#> 11625 1448666
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#> 11627 1448668
#> 11628 1448669
#> 11629 1448670
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#> 11632 1448673
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#> 11636 1448677
#> 11637 1448915
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#> 11639 1449675
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#> 11642 1449724
#> 11643 1449750
#> 11644 1450363
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#> 11649 1451177
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#> 11658 1451190
#> 11659 1451191
#> 11660 1451192
#> 11661 1451193
#> 11662 1451200
#> 11663 1451201
#> 11664 1451202
#> 11665 1451203
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#> 11667 1451492
#> 11668 1451512
#> 11669 1451513
#> 11670 1451514
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#> 11672 1451516
#> 11673 1451517
#> 11674 1451518
#> 11675 1451519
#> 11676 1451520
#> 11677 1451521
#> 11678 1451522
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#> 11680 1451524
#> 11681 1451525
#> 11682 1452102
#> 11683 1452108
#> 11684 1452125
#> 11685 1452213
#> 11686 1452247
#> 11687 1452253
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#> 11689 1452256
#> 11690 1452257
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#> 11692 1452261
#> 11693 1452262
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#> 11695 1452265
#> 11696 1452266
#> 11697 1452279
#> 11698 1452327
#> 11699 1452613
#> 11700 1452614
#> 11701 1452615
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#> 11703 1452789
#> 11704 1452790
#> 11705 1453057
#> 11706 1453200
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#> 11708 1453470
#> 11709 1453475
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#> 11712 1453478
#> 11713 1453479
#> 11714 1453480
#> 11715 1453481
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#> 11719 1453485
#> 11720 1453486
#> 11721 1453487
#> 11722 1453488
#> 11723 1453489
#> 11724 1453490
#> 11725 1453491
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#> 11727 1453493
#> 11728 1453494
#> 11729 1453695
#> 11730 1453887
#> 11731 1453888
#> 11732 1453889
#> 11733 1453910
#> 11734 1453922
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#> 11783 1457677
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#> 11789 1458342
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#> 11797 1458387
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#> 11800 1458390
#> 11801 1458391
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#> 11803 1458393
#> 11804 1458394
#> 11805 1458395
#> 11806 1458402
#> 11807 1458403
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#> 11809 1458693
#> 11810 1458821
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#> 11812 1458881
#> 11813 1458883
#> 11814 1458885
#> 11815 1458887
#> 11816 1459193
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#> 11819 1459196
#> 11820 1459197
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#> 11822 1459202
#> 11823 1459203
#> 11824 1459204
#> 11825 1459611
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#> 11827 1459618
#> 11828 1459619
#> 11829 1459630
#> 11830 1459829
#> 11831 1459830
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#> 11841 1460295
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#> 11846 1460611
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#> 11848 1460868
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#> 11852 1462042
#> 11853 1462043
#> 11854 1463416
#> 11855 1463437
#> 11856 1463438
#> 11857 1463444
#> 11858 1463976
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#> 11860 1463979
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#> 11862 1463981
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#> 11865 1464224
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#> 11870 1464229
#> 11871 1464782
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#> 11873 1465169
#> 11874 1465531
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#> 11882 1465539
#> 11883 1465540
#> 11884 1465929
#> 11885 1465940
#> 11886 1465941
#> 11887 1465994
#> 11888 1465995
#> 11889 1466056
#> 11890 1466162
#> 11891 1466167
#> 11892 1466168
#> 11893 1466169
#> 11894 1466170
#> 11895 1466171
#> 11896 1466172
#> 11897 1466173
#> 11898 1466174
#> 11899 1466175
#> 11900 1466176
#> 11901 1466177
#> 11902 1466178
#> 11903 1466179
#> 11904 1466180
#> 11905 1466181
#> 11906 1466182
#> 11907 1466183
#> 11908 1466184
#> 11909 1466185
#> 11910 1466186
#> 11911 1466243
#> 11912 1466249
#> 11913 1466250
#> 11914 1466251
#> 11915 1466252
#> 11916 1466253
#> 11917 1466254
#> 11918 1466255
#> 11919 1466256
#> 11920 1466257
#> 11921 1466258
#> 11922 1466354
#> 11923 1466708
#> 11924 1466729
#> 11925 1466730
#> 11926 1466731
#> 11927 1466732
#> 11928 1466736
#> 11929 1467167
#> 11930 1467286
#> 11931 1467295
#> 11932 1467329
#> 11933 1467330
#> 11934 1467331
#> 11935 1467332
#> 11936 1467333
#> 11937 1467334
#> 11938 1467344
#> 11939 1467345
#> 11940 1467346
#> 11941 1467347
#> 11942 1467590
#> 11943 1467732
#> 11944 1467735
#> 11945 1468094
#> 11946 1468136
#> 11947 1468137
#> 11948 1468138
#> 11949 1468139
#> 11950 1468148
#> 11951 1468149
#> 11952 1468155
#> 11953 1468160
#> 11954 1468165
#> 11955 1468170
#> 11956 1468175
#> 11957 1469211
#> 11958 1469214
#> 11959 1469226
#> 11960 1469227
#> 11961 1469802
#> 11962 1470745
#> 11963 1470749
#> 11964 1470770
#> 11965 1470772
#> 11966 1470781
#> 11967 1470784
#> 11968 1470788
#> 11969 1470917
#> 11970 1470921
#> 11971 1470922
#> 11972 1471049
#> 11973 1471052
#> 11974 1471053
#> 11975 1471096
#> 11976 1471178
#> 11977 1471422
#> 11978 1471732
#> 11979 1471736
#> 11980 1472959
#> 11981 1474397
#> 11982 1474400
#> 11983 1474888
#> 11984 1475680
#> 11985 1475681
#> 11986 1475682
#> 11987 1475793
#> 11988 1475794
#> 11989 1475795
#> 11990 1475796
#> 11991 1475797
#> 11992 1475798
#> 11993 1475804
#> 11994 1475805
#> 11995 1475806
#> 11996 1475809
#> 11997 1475810
#> 11998 1475811
#> 11999 1475812
#> 12000 1476840
#> 12001 1478423
#> 12002 1478427
#> 12003 1478428
#> 12004 1478429
#> 12005 1478430
#> 12006 1478431
#> 12007 1478432
#> 12008 1478433
#> 12009 1478434
#> 12010 1478435
#> 12011 1478436
#> 12012 1478437
#> 12013 1478480
#> 12014 1478481
#> 12015 1478482
#> 12016 1478483
#> 12017 1478484
#> 12018 1478485
#> 12019 1478486
#> 12020 1478590
#> 12021 1478598
#> 12022 1478701
#> 12023 1478702
#> 12024 1478727
#> 12025 1478745
#> 12026 1478746
#> 12027 1478817
#> 12028 1480298
#> 12029 1480299
#> 12030 1480300
#> 12031 1480587
#> 12032 1480668
#> 12033 1480672
#> 12034 1480675
#> 12035 1480676
#> 12036 1480677
#> 12037 1480678
#> 12038 1480679
#> 12039 1480680
#> 12040 1480681
#> 12041 1480682
#> 12042 1480683
#> 12043 1480684
#> 12044 1480685
#> 12045 1480686
#> 12046 1480687
#> 12047 1480688
#> 12048 1480689
#> 12049 1480690
#> 12050 1480691
#> 12051 1480692
#> 12052 1480693
#> 12053 1480694
#> 12054 1480695
#> 12055 1480696
#> 12056 1480697
#> 12057 1480698
#> 12058 1480699
#> 12059 1480700
#> 12060 1480701
#> 12061 1480702
#> 12062 1480703
#> 12063 1480704
#> 12064 1480705
#> 12065 1480706
#> 12066 1480707
#> 12067 1480708
#> 12068 1480709
#> 12069 1480710
#> 12070 1480711
#> 12071 1480712
#> 12072 1480713
#> 12073 1480738
#> 12074 1480744
#> 12075 1480749
#> 12076 1481785
#> 12077 1482176
#> 12078 1482178
#> 12079 1482180
#> 12080 1482182
#> 12081 1483567
#> 12082 1483572
#> 12083 1483823
#> 12084 1484986
#> 12085 1485222
#> 12086 1485223
#> 12087 1485224
#> 12088 1485225
#> 12089 1485226
#> 12090 1485227
#> 12091 1485228
#> 12092 1485229
#> 12093 1485230
#> 12094 1485231
#> 12095 1485240
#> 12096 1485241
#> 12097 1485242
#> 12098 1485257
#> 12099 1485258
#> 12100 1485259
#> 12101 1485260
#> 12102 1485261
#> 12103 1485262
#> 12104 1485263
#> 12105 1486250
#> 12106 1486299
#> 12107 1486673
#> 12108 1486761
#> 12109 1487202
#> 12110 1487203
#> 12111 1487504
#> 12112 1487508
#> 12113 1487509
#> 12114 1487510
#> 12115 1487511
#> 12116 1487512
#> 12117 1487514
#> 12118 1487515
#> 12119 1487516
#> 12120 1487691
#> 12121 1487692
#> 12122 1487693
#> 12123 1487694
#> 12124 1487695
#> 12125 1487696
#> 12126 1487697
#> 12127 1487698
#> 12128 1487699
#> 12129 1487700
#> 12130 1487701
#> 12131 1487702
#> 12132 1487703
#> 12133 1487704
#> 12134 1487705
#> 12135 1487716
#> 12136 1488291
#> 12137 1488397
#> 12138 1488398
#> 12139 1488487
#> 12140 1488615
#> 12141 1488687
#> 12142 1488707
#> 12143 1489043
#> 12144 1489075
#> 12145 1489127
#> 12146 1489378
#> 12147 1489605
#> 12148 1490938
#> 12149 1490950
#> 12150 1490954
#> 12151 1490955
#> 12152 1490956
#> 12153 1490959
#> 12154 1491051
#> 12155 1491121
#> 12156 1491122
#> 12157 1491123
#> 12158 1491209
#> 12159 1491469
#> 12160 1491478
#> 12161 1491479
#> 12162 1491480
#> 12163 1491481
#> 12164 1491483
#> 12165 1492837
#> 12166 1493938
#> 12167 1493969
#> 12168 1495471
#> 12169 1496084
#> 12170 1496299
#> 12171 1497216
#> 12172 1497324
#> 12173 1497329
#> 12174 1497330
#> 12175 1497331
#> 12176 1497332
#> 12177 1497333
#> 12178 1497334
#> 12179 1497335
#> 12180 1497336
#> 12181 1497337
#> 12182 1497338
#> 12183 1497339
#> 12184 1497340
#> 12185 1497341
#> 12186 1497342
#> 12187 1497343
#> 12188 1497344
#> 12189 1497345
#> 12190 1497346
#> 12191 1497347
#> 12192 1497348
#> 12193 1497349
#> 12194 1497350
#> 12195 1497351
#> 12196 1497352
#> 12197 1497353
#> 12198 1497354
#> 12199 1497355
#> 12200 1497601
#> 12201 1497619
#> 12202 1497696
#> 12203 1498138
#> 12204 1498375
#> 12205 1498975
#> 12206 1499200
#> 12207 1499244
#> 12208 1500282
#> 12209 1500913
#> 12210 1500915
#> 12211 1501177
#> 12212 1501688
#> 12213 1501911
#> 12214 1503033
#> 12215 1503043
#> 12216 1503044
#> 12217 1503477
#> 12218 1503613
#> 12219 1503615
#> 12220 1503617
#> 12221 1503724
#> 12222 1503736
#> 12223 1503760
#> 12224 1504183
#> 12225 1504263
#> 12226 1504286
#> 12227 1504423
#> 12228 1504424
#> 12229 1504508
#> 12230 1504527
#> 12231 1504728
#> 12232 1504729
#> 12233 1504730
#> 12234 1504734
#> 12235 1504739
#> 12236 1504740
#> 12237 1504769
#> 12238 1504868
#> 12239 1505179
#> 12240 1506516
#> 12241 1506694
#> 12242 1506733
#> 12243 1506878
#> 12244 1507657
#> 12245 1507679
#> 12246 1507904
#> 12247 1507909
#> 12248 1507913
#> 12249 1509521
#> 12250 1511021
#> 12251 1511022
#> 12252 1511023
#> 12253 1511024
#> 12254 1511027
#> 12255 1511043
#> 12256 1511217
#> 12257 1511227
#> 12258 1511235
#> 12259 1511464
#> 12260 1511465
#> 12261 1511466
#> 12262 1512194
#> 12263 1512675
#> 12264 1512696
#> 12265 1513911
#> 12266 1513912
#> 12267 1514432
#> 12268 1514436
#> 12269 1514437
#> 12270 1514438
#> 12271 1514439
#> 12272 1514440
#> 12273 1514441
#> 12274 1514442
#> 12275 1514582
#> 12276 1514583
#> 12277 1515182
#> 12278 1515186
#> 12279 1515187
#> 12280 1515188
#> 12281 1515189
#> 12282 1515190
#> 12283 1515191
#> 12284 1515192
#> 12285 1515193
#> 12286 1515194
#> 12287 1515195
#> 12288 1515196
#> 12289 1515197
#> 12290 1515198
#> 12291 1515199
#> 12292 1515200
#> 12293 1515201
#> 12294 1515202
#> 12295 1515203
#> 12296 1515204
#> 12297 1515205
#> 12298 1515206
#> 12299 1515207
#> 12300 1515208
#> 12301 1515209
#> 12302 1515210
#> 12303 1515211
#> 12304 1515212
#> 12305 1515213
#> 12306 1515214
#> 12307 1515215
#> 12308 1515216
#> 12309 1515219
#> 12310 1515220
#> 12311 1515221
#> 12312 1515222
#> 12313 1515223
#> 12314 1515224
#> 12315 1515225
#> 12316 1515226
#> 12317 1515238
#> 12318 1515383
#> 12319 1515384
#> 12320 1515385
#> 12321 1515386
#> 12322 1515388
#> 12323 1515389
#> 12324 1515390
#> 12325 1515391
#> 12326 1515396
#> 12327 1517357
#> 12328 1517361
#> 12329 1517362
#> 12330 1517363
#> 12331 1517364
#> 12332 1517365
#> 12333 1517366
#> 12334 1517367
#> 12335 1517368
#> 12336 1517369
#> 12337 1517370
#> 12338 1517371
#> 12339 1517372
#> 12340 1517373
#> 12341 1517374
#> 12342 1517375
#> 12343 1517376
#> 12344 1517377
#> 12345 1517378
#> 12346 1517379
#> 12347 1517380
#> 12348 1517381
#> 12349 1517382
#> 12350 1517383
#> 12351 1517384
#> 12352 1517385
#> 12353 1517386
#> 12354 1517387
#> 12355 1517388
#> 12356 1517389
#> 12357 1517390
#> 12358 1517391
#> 12359 1517392
#> 12360 1517393
#> 12361 1517394
#> 12362 1517395
#> 12363 1517396
#> 12364 1517397
#> 12365 1517398
#> 12366 1517399
#> 12367 1517400
#> 12368 1517401
#> 12369 1518071
#> 12370 1519240
#> 12371 1519241
#> 12372 1519242
#> 12373 1519243
#> 12374 1519244
#> 12375 1519245
#> 12376 1519412
#> 12377 1519439
#> 12378 1519440
#> 12379 1519441
#> 12380 1519442
#> 12381 1519640
#> 12382 1520043
#> 12383 1520047
#> 12384 1520048
#> 12385 1520050
#> 12386 1520051
#> 12387 1520141
#> 12388 1520144
#> 12389 1520145
#> 12390 1520213
#> 12391 1520217
#> 12392 1520221
#> 12393 1520268
#> 12394 1520269
#> 12395 1520270
#> 12396 1520271
#> 12397 1520272
#> 12398 1520273
#> 12399 1520329
#> 12400 1520345
#> 12401 1520369
#> 12402 1520393
#> 12403 1524219
#> 12404 1524241
#> 12405 1524242
#> 12406 1524243
#> 12407 1524244
#> 12408 1524245
#> 12409 1524246
#> 12410 1524247
#> 12411 1524248
#> 12412 1524249
#> 12413 1524250
#> 12414 1524251
#> 12415 1524252
#> 12416 1524254
#> 12417 1524256
#> 12418 1524258
#> 12419 1524259
#> 12420 1524262
#> 12421 1524265
#> 12422 1524266
#> 12423 1524273
#> 12424 1524275
#> 12425 1524277
#> 12426 1524278
#> 12427 1524284
#> 12428 1524285
#> 12429 1524286
#> 12430 1524287
#> 12431 1524289
#> 12432 1524291
#> 12433 1524293
#> 12434 1524294
#> 12435 1524296
#> 12436 1524298
#> 12437 1524300
#> 12438 1524307
#> 12439 1524308
#> 12440 1524309
#> 12441 1524310
#> 12442 1524311
#> 12443 1524312
#> 12444 1524318
#> 12445 1524323
#> 12446 1524342
#> 12447 1524345
#> 12448 1524348
#> 12449 1524351
#> 12450 1524354
#> 12451 1524361
#> 12452 1524362
#> 12453 1524363
#> 12454 1524364
#> 12455 1524365
#> 12456 1524366
#> 12457 1524369
#> 12458 1524370
#> 12459 1524371
#> 12460 1524372
#> 12461 1524373
#> 12462 1524374
#> 12463 1524375
#> 12464 1524556
#> 12465 1524561
#> 12466 1524573
#> 12467 1524601
#> 12468 1524652
#> 12469 1525028
#> 12470 1525044
#> 12471 1525059
#> 12472 1525060
#> 12473 1525198
#> 12474 1525202
#> 12475 1525206
#> 12476 1525207
#> 12477 1525208
#> 12478 1525209
#> 12479 1525210
#> 12480 1525211
#> 12481 1525212
#> 12482 1525248
#> 12483 1525715
#> 12484 1525716
#> 12485 1525719
#> 12486 1525720
#> 12487 1525721
#> 12488 1525722
#> 12489 1525723
#> 12490 1525724
#> 12491 1525725
#> 12492 1525726
#> 12493 1525727
#> 12494 1525728
#> 12495 1525729
#> 12496 1525730
#> 12497 1525731
#> 12498 1525732
#> 12499 1525733
#> 12500 1525734
#> 12501 1525735
#> 12502 1525736
#> 12503 1525737
#> 12504 1525738
#> 12505 1525739
#> 12506 1525740
#> 12507 1525741
#> 12508 1525742
#> 12509 1525743
#> 12510 1525744
#> 12511 1525745
#> 12512 1525746
#> 12513 1525747
#> 12514 1525748
#> 12515 1525749
#> 12516 1525750
#> 12517 1525751
#> 12518 1525752
#> 12519 1525753
#> 12520 1525754
#> 12521 1525755
#> 12522 1525757
#> 12523 1525758
#> 12524 1525759
#> 12525 1525760
#> 12526 1525761
#> 12527 1525762
#> 12528 1525763
#> 12529 1525764
#> 12530 1525765
#> 12531 1525766
#> 12532 1525767
#> 12533 1525770
#> 12534 1525771
#> 12535 1525783
#> 12536 1525785
#> 12537 1525786
#> 12538 1525787
#> 12539 1525788
#> 12540 1525789
#> 12541 1525790
#> 12542 1525791
#> 12543 1525798
#> 12544 1525881
#> 12545 1528517
#> 12546 1528729
#> 12547 1529212
#> 12548 1529217
#> 12549 1529218
#> 12550 1529221
#> 12551 1529869
#> 12552 1529998
#> 12553 1530488
#> 12554 1530489
#> 12555 1530490
#> 12556 1530501
#> 12557 1530524
#> 12558 1532050
#> 12559 1532244
#> 12560 1532245
#> 12561 1532246
#> 12562 1532247
#> 12563 1532248
#> 12564 1532249
#> 12565 1532250
#> 12566 1532251
#> 12567 1532252
#> 12568 1532253
#> 12569 1532254
#> 12570 1532255
#> 12571 1532256
#> 12572 1532257
#> 12573 1532258
#> 12574 1532259
#> 12575 1532260
#> 12576 1532261
#> 12577 1532262
#> 12578 1532263
#> 12579 1532264
#> 12580 1532265
#> 12581 1532266
#> 12582 1532267
#> 12583 1532268
#> 12584 1532269
#> 12585 1532270
#> 12586 1532271
#> 12587 1532272
#> 12588 1532273
#> 12589 1532274
#> 12590 1532275
#> 12591 1532466
#> 12592 1532473
#> 12593 1532474
#> 12594 1532475
#> 12595 1532491
#> 12596 1532492
#> 12597 1532500
#> 12598 1532505
#> 12599 1532506
#> 12600 1532507
#> 12601 1532508
#> 12602 1532509
#> 12603 1532510
#> 12604 1532662
#> 12605 1532663
#> 12606 1532683
#> 12607 1532691
#> 12608 1532692
#> 12609 1532710
#> 12610 1532846
#> 12611 1532855
#> 12612 1532866
#> 12613 1533309
#> 12614 1533310
#> 12615 1533462
#> 12616 1533529
#> 12617 1533531
#> 12618 1533532
#> 12619 1533533
#> 12620 1533534
#> 12621 1533535
#> 12622 1533536
#> 12623 1533537
#> 12624 1533538
#> 12625 1533539
#> 12626 1533540
#> 12627 1533541
#> 12628 1533542
#> 12629 1533543
#> 12630 1533544
#> 12631 1533545
#> 12632 1533546
#> 12633 1533547
#> 12634 1533548
#> 12635 1533558
#> 12636 1534694
#> 12637 1534704
#> 12638 1535014
#> 12639 1535572
#> 12640 1536153
#> 12641 1537019
#> 12642 1537025
#> 12643 1537190
#> 12644 1537194
#> 12645 1537196
#> 12646 1537197
#> 12647 1537198
#> 12648 1537199
#> 12649 1537200
#> 12650 1537201
#> 12651 1537202
#> 12652 1537203
#> 12653 1537387
#> 12654 1537388
#> 12655 1537389
#> 12656 1537391
#> 12657 1537392
#> 12658 1537393
#> 12659 1537394
#> 12660 1537395
#> 12661 1537669
#> 12662 1537715
#> 12663 1537835
#> 12664 1537847
#> 12665 1538664
#> 12666 1538679
#> 12667 1538700
#> 12668 1538708
#> 12669 1538724
#> 12670 1538725
#> 12671 1538726
#> 12672 1538727
#> 12673 1538728
#> 12674 1538729
#> 12675 1538730
#> 12676 1538731
#> 12677 1538732
#> 12678 1538733
#> 12679 1538734
#> 12680 1538735
#> 12681 1538736
#> 12682 1538737
#> 12683 1538738
#> 12684 1539056
#> 12685 1539057
#> 12686 1539063
#> 12687 1539071
#> 12688 1539072
#> 12689 1539073
#> 12690 1539074
#> 12691 1539075
#> 12692 1539076
#> 12693 1539077
#> 12694 1539079
#> 12695 1539082
#> 12696 1539103
#> 12697 1539104
#> 12698 1539108
#> 12699 1540252
#> 12700 1540632
#> 12701 1541664
#> 12702 1541723
#> 12703 1541741
#> 12704 1541742
#> 12705 1541743
#> 12706 1541746
#> 12707 1541747
#> 12708 1541748
#> 12709 1541749
#> 12710 1541750
#> 12711 1541751
#> 12712 1541752
#> 12713 1541753
#> 12714 1541754
#> 12715 1541755
#> 12716 1541756
#> 12717 1541757
#> 12718 1541758
#> 12719 1541759
#> 12720 1541760
#> 12721 1541761
#> 12722 1541762
#> 12723 1541763
#> 12724 1541764
#> 12725 1541765
#> 12726 1541766
#> 12727 1541767
#> 12728 1542169
#> 12729 1542923
#> 12730 1543034
#> 12731 1543120
#> 12732 1543126
#> 12733 1543186
#> 12734 1543459
#> 12735 1543503
#> 12736 1543506
#> 12737 1543507
#> 12738 1543509
#> 12739 1543511
#> 12740 1543513
#> 12741 1543515
#> 12742 1543517
#> 12743 1543519
#> 12744 1543523
#> 12745 1544072
#> 12746 1544398
#> 12747 1544657
#> 12748 1544658
#> 12749 1544659
#> 12750 1544660
#> 12751 1544661
#> 12752 1544662
#> 12753 1544789
#> 12754 1545041
#> 12755 1545102
#> 12756 1545103
#> 12757 1545105
#> 12758 1545106
#> 12759 1545120
#> 12760 1545410
#> 12761 1545757
#> 12762 1545777
#> 12763 1545844
#> 12764 1545849
#> 12765 1545855
#> 12766 1545866
#> 12767 1545879
#> 12768 1545881
#> 12769 1545905
#> 12770 1545953
#> 12771 1545993
#> 12772 1546456
#> 12773 1546536
#> 12774 1546556
#> 12775 1546565
#> 12776 1546572
#> 12777 1546624
#> 12778 1546626
#> 12779 1546630
#> 12780 1546631
#> 12781 1546799
#> 12782 1546809
#> 12783 1546982
#> 12784 1547112
#> 12785 1547148
#> 12786 1547959
#> 12787 1547967
#> 12788 1548244
#> 12789 1548256
#> 12790 1548257
#> 12791 1548986
#> 12792 1548987
#> 12793 1549101
#> 12794 1549674
#> 12795 1549868
#> 12796 1549906
#> 12797 1549917
#> 12798 1549920
#> 12799 1549929
#> 12800 1549934
#> 12801 1549935
#> 12802 1550000
#> 12803 1550094
#> 12804 1550096
#> 12805 1550103
#> 12806 1550542
#> 12807 1550785
#> 12808 1550794
#> 12809 1550795
#> 12810 1550796
#> 12811 1550797
#> 12812 1551329
#> 12813 1551768
#> 12814 1551769
#> 12815 1551893
#> 12816 1552549
#> 12817 1552710
#> 12818 1552862
#> 12819 1553416
#> 12820 1555771
#> 12821 1555772
#> 12822 1555773
#> 12823 1555827
#> 12824 1555834
#> 12825 1556024
#> 12826 1556109
#> 12827 1556148
#> 12828 1556149
#> 12829 1556150
#> 12830 1556151
#> 12831 1556162
#> 12832 1556163
#> 12833 1556604
#> 12834 1556835
#> 12835 1556842
#> 12836 1556846
#> 12837 1557387
#> 12838 1557391
#> 12839 1557398
#> 12840 1557466
#> 12841 1557960
#> 12842 1558384
#> 12843 1558412
#> 12844 1558434
#> 12845 1558483
#> 12846 1558800
#> 12847 1558802
#> 12848 1558803
#> 12849 1558804
#> 12850 1558805
#> 12851 1558806
#> 12852 1559382
#> 12853 1559492
#> 12854 1559494
#> 12855 1559496
#> 12856 1559497
#> 12857 1559500
#> 12858 1559503
#> 12859 1559505
#> 12860 1559506
#> 12861 1559509
#> 12862 1559511
#> 12863 1559514
#> 12864 1559517
#> 12865 1559519
#> 12866 1559521
#> 12867 1559523
#> 12868 1559525
#> 12869 1559527
#> 12870 1559529
#> 12871 1559531
#> 12872 1559532
#> 12873 1559535
#> 12874 1559537
#> 12875 1559539
#> 12876 1559541
#> 12877 1559543
#> 12878 1559545
#> 12879 1559547
#> 12880 1560693
#> 12881 1560787
#> 12882 1561076
#> 12883 1561152
#> 12884 1561153
#> 12885 1561172
#> 12886 1561173
#> 12887 1561176
#> 12888 1561178
#> 12889 1561179
#> 12890 1561180
#> 12891 1561181
#> 12892 1561182
#> 12893 1561183
#> 12894 1561184
#> 12895 1561185
#> 12896 1561187
#> 12897 1561188
#> 12898 1561189
#> 12899 1561190
#> 12900 1561193
#> 12901 1561194
#> 12902 1561195
#> 12903 1561196
#> 12904 1561197
#> 12905 1561198
#> 12906 1561199
#> 12907 1561200
#> 12908 1561201
#> 12909 1561202
#> 12910 1561271
#> 12911 1561275
#> 12912 1561331
#> 12913 1562379
#> 12914 1562382
#> 12915 1562766
#> 12916 1562843
#> 12917 1562944
#> 12918 1562985
#> 12919 1564182
#> 12920 1564441
#> 12921 1564454
#> 12922 1564455
#> 12923 1564456
#> 12924 1564457
#> 12925 1564458
#> 12926 1564459
#> 12927 1564460
#> 12928 1564461
#> 12929 1564462
#> 12930 1564463
#> 12931 1564464
#> 12932 1564465
#> 12933 1564481
#> 12934 1564482
#> 12935 1564483
#> 12936 1564484
#> 12937 1564485
#> 12938 1564774
#> 12939 1564790
#> 12940 1564791
#> 12941 1564792
#> 12942 1564793
#> 12943 1565073
#> 12944 1565721
#> 12945 1565922
#> 12946 1566496
#> 12947 1566497
#> 12948 1566537
#> 12949 1566557
#> 12950 1566942
#> 12951 1567110
#> 12952 1567111
#> 12953 1567217
#> 12954 1567364
#> 12955 1567367
#> 12956 1567604
#> 12957 1567606
#> 12958 1568249
#> 12959 1568290
#> 12960 1568297
#> 12961 1568298
#> 12962 1568299
#> 12963 1568300
#> 12964 1568312
#> 12965 1568317
#> 12966 1568318
#> 12967 1568319
#> 12968 1568320
#> 12969 1568321
#> 12970 1568329
#> 12971 1568330
#> 12972 1568731
#> 12973 1568733
#> 12974 1568869
#> 12975 1568971
#> 12976 1569611
#> 12977 1569612
#> 12978 1570108
#> 12979 1570325
#> 12980 1570334
#> 12981 1570338
#> 12982 1570341
#> 12983 1570368
#> 12984 1570369
#> 12985 1570370
#> 12986 1570371
#> 12987 1570372
#> 12988 1570808
#> 12989 1570809
#> 12990 1570810
#> 12991 1570811
#> 12992 1570812
#> 12993 1571163
#> 12994 1571172
#> 12995 1571185
#> 12996 1571188
#> 12997 1571427
#> 12998 1571511
#> 12999 1571517
#> 13000 1571558
#> 13001 1571559
#> 13002 1571599
#> 13003 1571600
#> 13004 1571601
#> 13005 1571602
#> 13006 1571603
#> 13007 1571604
#> 13008 1571606
#> 13009 1571607
#> 13010 1571608
#> 13011 1571609
#> 13012 1571610
#> 13013 1571611
#> 13014 1571612
#> 13015 1571613
#> 13016 1571614
#> 13017 1571615
#> 13018 1571616
#> 13019 1571621
#> 13020 1572255
#> 13021 1572263
#> 13022 1572264
#> 13023 1572265
#> 13024 1572266
#> 13025 1572267
#> 13026 1572269
#> 13027 1572270
#> 13028 1572271
#> 13029 1572272
#> 13030 1572273
#> 13031 1572287
#> 13032 1572556
#> 13033 1572568
#> 13034 1572569
#> 13035 1572570
#> 13036 1572571
#> 13037 1572572
#> 13038 1572573
#> 13039 1572574
#> 13040 1572580
#> 13041 1572591
#> 13042 1572598
#> 13043 1572839
#> 13044 1572840
#> 13045 1572848
#> 13046 1572849
#> 13047 1574047
#> 13048 1574088
#> 13049 1574089
#> 13050 1574195
#> 13051 1574269
#> 13052 1574272
#> 13053 1574273
#> 13054 1574274
#> 13055 1574275
#> 13056 1574276
#> 13057 1574277
#> 13058 1574278
#> 13059 1574279
#> 13060 1574280
#> 13061 1574284
#> 13062 1574285
#> 13063 1574435
#> 13064 1574436
#> 13065 1574450
#> 13066 1574451
#> 13067 1574497
#> 13068 1574498
#> 13069 1574499
#> 13070 1574500
#> 13071 1574501
#> 13072 1574502
#> 13073 1574503
#> 13074 1574504
#> 13075 1574505
#> 13076 1574506
#> 13077 1574507
#> 13078 1574595
#> 13079 1574596
#> 13080 1574597
#> 13081 1574598
#> 13082 1574599
#> 13083 1574609
#> 13084 1574611
#> 13085 1574612
#> 13086 1574613
#> 13087 1575077
#> 13088 1575291
#> 13089 1575293
#> 13090 1575480
#> 13091 1575595
#> 13092 1575634
#> 13093 1576848
#> 13094 1576849
#> 13095 1576850
#> 13096 1577581
#> 13097 1577643
#> 13098 1577659
#> 13099 1577663
#> 13100 1577682
#> 13101 1577692
#> 13102 1577700
#> 13103 1577718
#> 13104 1577724
#> 13105 1577896
#> 13106 1578156
#> 13107 1578239
#> 13108 1578247
#> 13109 1578248
#> 13110 1578249
#> 13111 1578250
#> 13112 1578251
#> 13113 1578252
#> 13114 1578253
#> 13115 1578254
#> 13116 1578255
#> 13117 1578256
#> 13118 1578257
#> 13119 1578258
#> 13120 1578515
#> 13121 1578516
#> 13122 1579160
#> 13123 1580238
#> 13124 1580659
#> 13125 1580663
#> 13126 1580691
#> 13127 1580692
#> 13128 1580693
#> 13129 1581560
#> 13130 1581820
#> 13131 1581821
#> 13132 1581822
#> 13133 1581823
#> 13134 1581987
#> 13135 1581988
#> 13136 1582591
#> 13137 1582701
#> 13138 1582702
#> 13139 1582703
#> 13140 1582704
#> 13141 1582705
#> 13142 1582706
#> 13143 1582707
#> 13144 1582708
#> 13145 1582709
#> 13146 1582710
#> 13147 1582711
#> 13148 1582712
#> 13149 1582716
#> 13150 1583164
#> 13151 1583165
#> 13152 1583364
#> 13153 1585715
#> 13154 1586322
#> 13155 1586360
#> 13156 1586767
#> 13157 1586782
#> 13158 1587303
#> 13159 1587308
#> 13160 1587358
#> 13161 1587635
#> 13162 1587831
#> 13163 1587852
#> 13164 1587860
#> 13165 1587861
#> 13166 1588021
#> 13167 1588122
#> 13168 1588343
#> 13169 1588374
#> 13170 1588375
#> 13171 1588376
#> 13172 1588377
#> 13173 1588379
#> 13174 1588383
#> 13175 1588385
#> 13176 1588386
#> 13177 1588387
#> 13178 1588388
#> 13179 1588389
#> 13180 1588390
#> 13181 1588498
#> 13182 1588500
#> 13183 1588585
#> 13184 1588962
#> 13185 1589101
#> 13186 1589102
#> 13187 1589103
#> 13188 1589104
#> 13189 1589113
#> 13190 1589114
#> 13191 1589115
#> 13192 1589116
#> 13193 1589117
#> 13194 1589143
#> 13195 1589147
#> 13196 1589218
#> 13197 1589219
#> 13198 1589220
#> 13199 1589221
#> 13200 1589660
#> 13201 1589825
#> 13202 1589949
#> 13203 1589950
#> 13204 1589955
#> 13205 1589993
#> 13206 1590016
#> 13207 1590027
#> 13208 1590028
#> 13209 1590029
#> 13210 1590030
#> 13211 1590031
#> 13212 1590147
#> 13213 1590317
#> 13214 1590318
#> 13215 1590319
#> 13216 1590320
#> 13217 1590321
#> 13218 1590322
#> 13219 1590323
#> 13220 1590324
#> 13221 1590325
#> 13222 1590326
#> 13223 1590327
#> 13224 1590329
#> 13225 1590330
#> 13226 1590331
#> 13227 1590332
#> 13228 1590333
#> 13229 1590334
#> 13230 1590335
#> 13231 1590336
#> 13232 1590337
#> 13233 1590338
#> 13234 1590339
#> 13235 1590340
#> 13236 1590341
#> 13237 1590342
#> 13238 1591559
#> 13239 1591718
#> 13240 1591719
#> 13241 1591738
#> 13242 1591746
#> 13243 1593167
#> 13244 1593198
#> 13245 1593199
#> 13246 1593200
#> 13247 1593204
#> 13248 1593648
#> 13249 1593806
#> 13250 1593819
#> 13251 1593820
#> 13252 1593821
#> 13253 1593822
#> 13254 1593823
#> 13255 1593824
#> 13256 1593825
#> 13257 1593826
#> 13258 1593827
#> 13259 1593828
#> 13260 1593829
#> 13261 1593830
#> 13262 1593831
#> 13263 1593832
#> 13264 1593833
#> 13265 1593834
#> 13266 1594084
#> 13267 1594306
#> 13268 1594754
#> 13269 1594759
#> 13270 1594769
#> 13271 1594820
#> 13272 1595375
#> 13273 1595377
#> 13274 1595393
#> 13275 1595394
#> 13276 1595395
#> 13277 1595396
#> 13278 1595397
#> 13279 1595398
#> 13280 1595399
#> 13281 1595510
#> 13282 1595517
#> 13283 1596037
#> 13284 1596038
#> 13285 1596046
#> 13286 1596080
#> 13287 1596510
#> 13288 1596511
#> 13289 1596512
#> 13290 1596513
#> 13291 1596514
#> 13292 1596515
#> 13293 1596516
#> 13294 1596517
#> 13295 1596518
#> 13296 1596519
#> 13297 1596520
#> 13298 1596521
#> 13299 1596522
#> 13300 1596523
#> 13301 1596524
#> 13302 1596525
#> 13303 1596527
#> 13304 1596528
#> 13305 1596529
#> 13306 1596530
#> 13307 1596531
#> 13308 1596532
#> 13309 1596533
#> 13310 1596630
#> 13311 1597179
#> 13312 1597753
#> 13313 1597754
#> 13314 1597755
#> 13315 1597756
#> 13316 1597758
#> 13317 1597759
#> 13318 1597760
#> 13319 1597761
#> 13320 1597762
#> 13321 1597763
#> 13322 1597764
#> 13323 1597765
#> 13324 1597766
#> 13325 1597767
#> 13326 1597768
#> 13327 1597769
#> 13328 1597770
#> 13329 1597930
#> 13330 1597933
#> 13331 1597974
#> 13332 1597990
#> 13333 1598974
#> 13334 1598975
#> 13335 1598980
#> 13336 1598982
#> 13337 1599128
#> 13338 1600524
#> 13339 1600528
#> 13340 1600531
#> 13341 1600533
#> 13342 1600535
#> 13343 1600546
#> 13344 1600547
#> 13345 1600548
#> 13346 1600549
#> 13347 1600550
#> 13348 1600556
#> 13349 1600557
#> 13350 1600565
#> 13351 1600566
#> 13352 1600567
#> 13353 1600568
#> 13354 1600569
#> 13355 1600570
#> 13356 1600571
#> 13357 1600572
#> 13358 1600573
#> 13359 1600574
#> 13360 1600575
#> 13361 1600576
#> 13362 1600577
#> 13363 1601488
#> 13364 1601493
#> 13365 1601639
#> 13366 1601642
#> 13367 1601643
#> 13368 1601644
#> 13369 1601645
#> 13370 1601646
#> 13371 1601647
#> 13372 1601648
#> 13373 1601649
#> 13374 1602814
#> 13375 1602815
#> 13376 1602816
#> 13377 1602817
#> 13378 1602818
#> 13379 1602819
#> 13380 1602820
#> 13381 1602821
#> 13382 1602822
#> 13383 1602823
#> 13384 1602824
#> 13385 1603320
#> 13386 1603736
#> 13387 1604037
#> 13388 1604224
#> 13389 1604229
#> 13390 1604231
#> 13391 1604240
#> 13392 1604277
#> 13393 1604381
#> 13394 1604742
#> 13395 1605076
#> 13396 1605100
#> 13397 1605720
#> 13398 1605721
#> 13399 1606936
#> 13400 1607705
#> 13401 1607707
#> 13402 1607708
#> 13403 1607709
#> 13404 1607728
#> 13405 1607742
#> 13406 1607751
#> 13407 1607752
#> 13408 1608324
#> 13409 1608496
#> 13410 1608513
#> 13411 1608530
#> 13412 1608531
#> 13413 1608544
#> 13414 1608545
#> 13415 1608546
#> 13416 1608550
#> 13417 1608554
#> 13418 1608558
#> 13419 1608562
#> 13420 1608877
#> 13421 1608881
#> 13422 1608888
#> 13423 1608892
#> 13424 1608894
#> 13425 1608898
#> 13426 1608954
#> 13427 1609129
#> 13428 1609130
#> 13429 1609175
#> 13430 1609229
#> 13431 1609779
#> 13432 1610065
#> 13433 1610070
#> 13434 1610074
#> 13435 1610136
#> 13436 1610228
#> 13437 1610229
#> 13438 1610230
#> 13439 1610231
#> 13440 1610250
#> 13441 1610365
#> 13442 1610373
#> 13443 1610654
#> 13444 1610891
#> 13445 1611265
#> 13446 1611268
#> 13447 1611269
#> 13448 1611270
#> 13449 1611271
#> 13450 1611272
#> 13451 1611273
#> 13452 1611274
#> 13453 1611275
#> 13454 1611276
#> 13455 1611277
#> 13456 1611522
#> 13457 1611848
#> 13458 1611979
#> 13459 1611994
#> 13460 1611999
#> 13461 1612001
#> 13462 1612035
#> 13463 1612054
#> 13464 1612088
#> 13465 1612329
#> 13466 1612697
#> 13467 1612875
#> 13468 1613072
#> 13469 1613392
#> 13470 1613395
#> 13471 1613396
#> 13472 1613398
#> 13473 1613399
#> 13474 1613400
#> 13475 1613401
#> 13476 1613402
#> 13477 1613403
#> 13478 1613404
#> 13479 1613405
#> 13480 1613406
#> 13481 1613407
#> 13482 1613408
#> 13483 1613409
#> 13484 1613410
#> 13485 1613411
#> 13486 1613412
#> 13487 1613413
#> 13488 1613414
#> 13489 1613415
#> 13490 1613416
#> 13491 1613417
#> 13492 1613418
#> 13493 1613419
#> 13494 1613420
#> 13495 1613421
#> 13496 1613422
#> 13497 1613423
#> 13498 1613424
#> 13499 1613425
#> 13500 1613454
#> 13501 1613455
#> 13502 1613456
#> 13503 1613460
#> 13504 1613461
#> 13505 1613462
#> 13506 1613463
#> 13507 1613464
#> 13508 1613465
#> 13509 1614561
#> 13510 1614566
#> 13511 1614573
#> 13512 1614575
#> 13513 1614778
#> 13514 1614779
#> 13515 1614780
#> 13516 1615814
#> 13517 1615872
#> 13518 1615886
#> 13519 1616251
#> 13520 1616268
#> 13521 1616271
#> 13522 1616534
#> 13523 1616535
#> 13524 1616541
#> 13525 1616542
#> 13526 1616746
#> 13527 1617181
#> 13528 1617607
#> 13529 1617645
#> 13530 1617686
#> 13531 1617921
#> 13532 1617925
#> 13533 1618682
#> 13534 1619139
#> 13535 1619616
#> 13536 1619617
#> 13537 1619625
#> 13538 1619626
#> 13539 1620067
#> 13540 1621185
#> 13541 1621186
#> 13542 1621187
#> 13543 1621404
#> 13544 1621405
#> 13545 1621406
#> 13546 1621407
#> 13547 1622847
#> 13548 1622899
#> 13549 1622903
#> 13550 1622907
#> 13551 1622908
#> 13552 1622912
#> 13553 1622954
#> 13554 1622970
#> 13555 1622984
#> 13556 1622985
#> 13557 1622986
#> 13558 1623005
#> 13559 1623064
#> 13560 1623546
#> 13561 1623820
#> 13562 1623892
#> 13563 1624018
#> 13564 1624020
#> 13565 1624022
#> 13566 1624058
#> 13567 1624059
#> 13568 1624061
#> 13569 1624062
#> 13570 1624064
#> 13571 1624065
#> 13572 1624068
#> 13573 1624070
#> 13574 1624073
#> 13575 1624075
#> 13576 1624076
#> 13577 1624077
#> 13578 1624078
#> 13579 1624079
#> 13580 1624080
#> 13581 1624083
#> 13582 1624084
#> 13583 1624085
#> 13584 1624086
#> 13585 1624087
#> 13586 1624088
#> 13587 1624089
#> 13588 1624090
#> 13589 1624091
#> 13590 1624092
#> 13591 1624107
#> 13592 1624108
#> 13593 1624143
#> 13594 1624627
#> 13595 1624729
#> 13596 1624730
#> 13597 1624731
#> 13598 1624732
#> 13599 1624733
#> 13600 1625019
#> 13601 1625138
#> 13602 1625194
#> 13603 1625197
#> 13604 1625198
#> 13605 1625199
#> 13606 1625200
#> 13607 1625201
#> 13608 1625202
#> 13609 1625203
#> 13610 1625204
#> 13611 1625205
#> 13612 1625206
#> 13613 1625207
#> 13614 1625208
#> 13615 1625209
#> 13616 1625210
#> 13617 1625211
#> 13618 1625212
#> 13619 1625213
#> 13620 1625214
#> 13621 1625215
#> 13622 1625216
#> 13623 1625430
#> 13624 1625454
#> 13625 1625935
#> 13626 1627187
#> 13627 1627665
#> 13628 1627857
#> 13629 1627858
#> 13630 1628237
#> 13631 1628277
#> 13632 1628283
#> 13633 1628399
#> 13634 1628522
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#> 13636 1628524
#> 13637 1628525
#> 13638 1628526
#> 13639 1628527
#> 13640 1628528
#> 13641 1628529
#> 13642 1628530
#> 13643 1628681
#> 13644 1628689
#> 13645 1628690
#> 13646 1628691
#> 13647 1628700
#> 13648 1628701
#> 13649 1628702
#> 13650 1628703
#> 13651 1628704
#> 13652 1628705
#> 13653 1628760
#> 13654 1628913
#> 13655 1628916
#> 13656 1628917
#> 13657 1628918
#> 13658 1628919
#> 13659 1628920
#> 13660 1628921
#> 13661 1628922
#> 13662 1628923
#> 13663 1628924
#> 13664 1628925
#> 13665 1628926
#> 13666 1628927
#> 13667 1628928
#> 13668 1628929
#> 13669 1630156
#> 13670 1630230
#> 13671 1630390
#> 13672 1630453
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#> 13674 1630455
#> 13675 1630456
#> 13676 1630457
#> 13677 1630466
#> 13678 1630467
#> 13679 1630669
#> 13680 1630670
#> 13681 1631064
#> 13682 1631595
#> 13683 1632122
#> 13684 1632183
#> 13685 1632483
#> 13686 1632654
#> 13687 1633545
#> 13688 1633801
#> 13689 1633802
#> 13690 1633803
#> 13691 1633808
#> 13692 1633816
#> 13693 1633826
#> 13694 1634209
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#> 13696 1634240
#> 13697 1634319
#> 13698 1634320
#> 13699 1634321
#> 13700 1634323
#> 13701 1635266
#> 13702 1635269
#> 13703 1635333
#> 13704 1635334
#> 13705 1635336
#> 13706 1636143
#> 13707 1637286
#> 13708 1637287
#> 13709 1637288
#> 13710 1637289
#> 13711 1637290
#> 13712 1637291
#> 13713 1637292
#> 13714 1637293
#> 13715 1637294
#> 13716 1637295
#> 13717 1637296
#> 13718 1637297
#> 13719 1637298
#> 13720 1637299
#> 13721 1637300
#> 13722 1637301
#> 13723 1637302
#> 13724 1637303
#> 13725 1637304
#> 13726 1637305
#> 13727 1637306
#> 13728 1637307
#> 13729 1637308
#> 13730 1637309
#> 13731 1637310
#> 13732 1637311
#> 13733 1637312
#> 13734 1637313
#> 13735 1637314
#> 13736 1637315
#> 13737 1637316
#> 13738 1637317
#> 13739 1637319
#> 13740 1637320
#> 13741 1637321
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#> 13743 1637323
#> 13744 1637324
#> 13745 1637325
#> 13746 1637326
#> 13747 1637327
#> 13748 1637328
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#> 13750 1637330
#> 13751 1637331
#> 13752 1637332
#> 13753 1637333
#> 13754 1637334
#> 13755 1637335
#> 13756 1637336
#> 13757 1637337
#> 13758 1637338
#> 13759 1637347
#> 13760 1637348
#> 13761 1637349
#> 13762 1637350
#> 13763 1637351
#> 13764 1637352
#> 13765 1637353
#> 13766 1637354
#> 13767 1637355
#> 13768 1637514
#> 13769 1637518
#> 13770 1637519
#> 13771 1637520
#> 13772 1637521
#> 13773 1637522
#> 13774 1637523
#> 13775 1637524
#> 13776 1637525
#> 13777 1637528
#> 13778 1637529
#> 13779 1637530
#> 13780 1637531
#> 13781 1637532
#> 13782 1637534
#> 13783 1637578
#> 13784 1637656
#> 13785 1637805
#> 13786 1637824
#> 13787 1638077
#> 13788 1638892
#> 13789 1639198
#> 13790 1639267
#> 13791 1639268
#> 13792 1639270
#> 13793 1639271
#> 13794 1639272
#> 13795 1639273
#> 13796 1639274
#> 13797 1639275
#> 13798 1639276
#> 13799 1639361
#> 13800 1639362
#> 13801 1639363
#> 13802 1639383
#> 13803 1639498
#> 13804 1639845
#> 13805 1639972
#> 13806 1646179
#> 13807 1646183
#> 13808 1646345
#> 13809 1646361
#> 13810 1646362
#> 13811 1646363
#> 13812 1646364
#> 13813 1646365
#> 13814 1646366
#> 13815 1646370
#> 13816 1646371
#> 13817 1646372
#> 13818 1646373
#> 13819 1646374
#> 13820 1646375
#> 13821 1646376
#> 13822 1646377
#> 13823 1646378
#> 13824 1646379
#> 13825 1646380
#> 13826 1646381
#> 13827 1646382
#> 13828 1647423
#> 13829 1647658
#> 13830 1647706
#> 13831 1647710
#> 13832 1647714
#> 13833 1647718
#> 13834 1647722
#> 13835 1647726
#> 13836 1647748
#> 13837 1647749
#> 13838 1647750
#> 13839 1647751
#> 13840 1647752
#> 13841 1647753
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#> 13843 1647755
#> 13844 1647756
#> 13845 1647775
#> 13846 1647776
#> 13847 1647777
#> 13848 1647778
#> 13849 1647779
#> 13850 1647792
#> 13851 1647804
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#> 13853 1647810
#> 13854 1647812
#> 13855 1647817
#> 13856 1647820
#> 13857 1647823
#> 13858 1647827
#> 13859 1647968
#> 13860 1647970
#> 13861 1647973
#> 13862 1648056
#> 13863 1648104
#> 13864 1648909
#> 13865 1649313
#> 13866 1649323
#> 13867 1649330
#> 13868 1649335
#> 13869 1649941
#> 13870 1650131
#> 13871 1650132
#> 13872 1650133
#> 13873 1650617
#> 13874 1650662
#> 13875 1650663
#> 13876 1650860
#> 13877 1650862
#> 13878 1650863
#> 13879 1651056
#> 13880 1651161
#> 13881 1651255
#> 13882 1651256
#> 13883 1651257
#> 13884 1651258
#> 13885 1651551
#> 13886 1651554
#> 13887 1651565
#> 13888 1651566
#> 13889 1651567
#> 13890 1651568
#> 13891 1651569
#> 13892 1651570
#> 13893 1652069
#> 13894 1652074
#> 13895 1652718
#> 13896 1653099
#> 13897 1653107
#> 13898 1653110
#> 13899 1653147
#> 13900 1653179
#> 13901 1653188
#> 13902 1653192
#> 13903 1653197
#> 13904 1653664
#> 13905 1653665
#> 13906 1653667
#> 13907 1653668
#> 13908 1653694
#> 13909 1653695
#> 13910 1653696
#> 13911 1653700
#> 13912 1653704
#> 13913 1653705
#> 13914 1653709
#> 13915 1653713
#> 13916 1653715
#> 13917 1653716
#> 13918 1653721
#> 13919 1653911
#> 13920 1653913
#> 13921 1653914
#> 13922 1653915
#> 13923 1653919
#> 13924 1653935
#> 13925 1653936
#> 13926 1654056
#> 13927 1654070
#> 13928 1654071
#> 13929 1654143
#> 13930 1654509
#> 13931 1654724
#> 13932 1655027
#> 13933 1655302
#> 13934 1655401
#> 13935 1655443
#> 13936 1655495
#> 13937 1655700
#> 13938 1655906
#> 13939 1655907
#> 13940 1655908
#> 13941 1656507
#> 13942 1656509
#> 13943 1656725
#> 13944 1656992
#> 13945 1657015
#> 13946 1657549
#> 13947 1657556
#> 13948 1657906
#> 13949 1658389
#> 13950 1658408
#> 13951 1658425
#> 13952 1658670
#> 13953 1658671
#> 13954 1658672
#> 13955 1658673
#> 13956 1658674
#> 13957 1658675
#> 13958 1658676
#> 13959 1658677
#> 13960 1658678
#> 13961 1658679
#> 13962 1658680
#> 13963 1658681
#> 13964 1658682
#> 13965 1658683
#> 13966 1658684
#> 13967 1658685
#> 13968 1658686
#> 13969 1658687
#> 13970 1658688
#> 13971 1658689
#> 13972 1658915
#> 13973 1658916
#> 13974 1658919
#> 13975 1658920
#> 13976 1659073
#> 13977 1659074
#> 13978 1659075
#> 13979 1659212
#> 13980 1659217
#> 13981 1659245
#> 13982 1659646
#> 13983 1659657
#> 13984 1659685
#> 13985 1659842
#> 13986 1659843
#> 13987 1659844
#> 13988 1659845
#> 13989 1659846
#> 13990 1659997
#> 13991 1659998
#> 13992 1659999
#> 13993 1660000
#> 13994 1660001
#> 13995 1660002
#> 13996 1660004
#> 13997 1660005
#> 13998 1660006
#> 13999 1660007
#> 14000 1660008
#> 14001 1660022
#> 14002 1660023
#> 14003 1660024
#> 14004 1660025
#> 14005 1660026
#> 14006 1660027
#> 14007 1660028
#> 14008 1660029
#> 14009 1660030
#> 14010 1660031
#> 14011 1660032
#> 14012 1660033
#> 14013 1660101
#> 14014 1660102
#> 14015 1660123
#> 14016 1660124
#> 14017 1660127
#> 14018 1660128
#> 14019 1660129
#> 14020 1660198
#> 14021 1660199
#> 14022 1660348
#> 14023 1660613
#> 14024 1660615
#> 14025 1660910
#> 14026 1660911
#> 14027 1660912
#> 14028 1660976
#> 14029 1660977
#> 14030 1660978
#> 14031 1660980
#> 14032 1660981
#> 14033 1660982
#> 14034 1660983
#> 14035 1660984
#> 14036 1661120
#> 14037 1661121
#> 14038 1661736
#> 14039 1661953
#> 14040 1662197
#> 14041 1662198
#> 14042 1662203
#> 14043 1662205
#> 14044 1662206
#> 14045 1662207
#> 14046 1662208
#> 14047 1662209
#> 14048 1662213
#> 14049 1662258
#> 14050 1662259
#> 14051 1662260
#> 14052 1662261
#> 14053 1662843
#> 14054 1663469
#> 14055 1663477
#> 14056 1663770
#> 14057 1663861
#> 14058 1664326
#> 14059 1664327
#> 14060 1664371
#> 14061 1664609
#> 14062 1664650
#> 14063 1664700
#> 14064 1664837
#> 14065 1664838
#> 14066 1664839
#> 14067 1664846
#> 14068 1664847
#> 14069 1664848
#> 14070 1664849
#> 14071 1664850
#> 14072 1664851
#> 14073 1664852
#> 14074 1664853
#> 14075 1664854
#> 14076 1664855
#> 14077 1664856
#> 14078 1664857
#> 14079 1664858
#> 14080 1664859
#> 14081 1664860
#> 14082 1664861
#> 14083 1664862
#> 14084 1664863
#> 14085 1664864
#> 14086 1664865
#> 14087 1664866
#> 14088 1664867
#> 14089 1664868
#> 14090 1664869
#> 14091 1664870
#> 14092 1664871
#> 14093 1664872
#> 14094 1664873
#> 14095 1664874
#> 14096 1664875
#> 14097 1664876
#> 14098 1664877
#> 14099 1664878
#> 14100 1664879
#> 14101 1664880
#> 14102 1664881
#> 14103 1664882
#> 14104 1664883
#> 14105 1664884
#> 14106 1664885
#> 14107 1664886
#> 14108 1664887
#> 14109 1664888
#> 14110 1664889
#> 14111 1664890
#> 14112 1664891
#> 14113 1664892
#> 14114 1664893
#> 14115 1664894
#> 14116 1664895
#> 14117 1664896
#> 14118 1664897
#> 14119 1664898
#> 14120 1664899
#> 14121 1664900
#> 14122 1664901
#> 14123 1664902
#> 14124 1664903
#> 14125 1664904
#> 14126 1665003
#> 14127 1666165
#> 14128 1666173
#> 14129 1666196
#> 14130 1666470
#> 14131 1666471
#> 14132 1666472
#> 14133 1666473
#> 14134 1666474
#> 14135 1666475
#> 14136 1666485
#> 14137 1666487
#> 14138 1666488
#> 14139 1666492
#> 14140 1666494
#> 14141 1666497
#> 14142 1666498
#> 14143 1666499
#> 14144 1666500
#> 14145 1666501
#> 14146 1666502
#> 14147 1666503
#> 14148 1666504
#> 14149 1666505
#> 14150 1666506
#> 14151 1666507
#> 14152 1666508
#> 14153 1666509
#> 14154 1666510
#> 14155 1666511
#> 14156 1666512
#> 14157 1666513
#> 14158 1666514
#> 14159 1666515
#> 14160 1666516
#> 14161 1666517
#> 14162 1666518
#> 14163 1666519
#> 14164 1666520
#> 14165 1666521
#> 14166 1666522
#> 14167 1666523
#> 14168 1666524
#> 14169 1666525
#> 14170 1666551
#> 14171 1666557
#> 14172 1666930
#> 14173 1666931
#> 14174 1666932
#> 14175 1666933
#> 14176 1666934
#> 14177 1666935
#> 14178 1666936
#> 14179 1667119
#> 14180 1667121
#> 14181 1667122
#> 14182 1667123
#> 14183 1667124
#> 14184 1667125
#> 14185 1667126
#> 14186 1667127
#> 14187 1667128
#> 14188 1667129
#> 14189 1667130
#> 14190 1667223
#> 14191 1667249
#> 14192 1667426
#> 14193 1667734
#> 14194 1667737
#> 14195 1667740
#> 14196 1667741
#> 14197 1667742
#> 14198 1667743
#> 14199 1667744
#> 14200 1668272
#> 14201 1668527
#> 14202 1668619
#> 14203 1668620
#> 14204 1668621
#> 14205 1668622
#> 14206 1668623
#> 14207 1668624
#> 14208 1668625
#> 14209 1668626
#> 14210 1668627
#> 14211 1669115
#> 14212 1669116
#> 14213 1669121
#> 14214 1669122
#> 14215 1669123
#> 14216 1669124
#> 14217 1669125
#> 14218 1669126
#> 14219 1669127
#> 14220 1669128
#> 14221 1669130
#> 14222 1669244
#> 14223 1669245
#> 14224 1669246
#> 14225 1673180
#> 14226 1673383
#> 14227 1674014
#> 14228 1674266
#> 14229 1674366
#> 14230 1675243
#> 14231 1675244
#> 14232 1675245
#> 14233 1675604
#> 14234 1676415
#> 14235 1677358
#> 14236 1677359
#> 14237 1677360
#> 14238 1677361
#> 14239 1677362
#> 14240 1677363
#> 14241 1677364
#> 14242 1677365
#> 14243 1677366
#> 14244 1677367
#> 14245 1677368
#> 14246 1677369
#> 14247 1677370
#> 14248 1677371
#> 14249 1677372
#> 14250 1677426
#> 14251 1677448
#> 14252 1677449
#> 14253 1677450
#> 14254 1677451
#> 14255 1677452
#> 14256 1677453
#> 14257 1677454
#> 14258 1677455
#> 14259 1677456
#> 14260 1677457
#> 14261 1677458
#> 14262 1677459
#> 14263 1677460
#> 14264 1677461
#> 14265 1677462
#> 14266 1677463
#> 14267 1677464
#> 14268 1677465
#> 14269 1677494
#> 14270 1677495
#> 14271 1677496
#> 14272 1677497
#> 14273 1677498
#> 14274 1677499
#> 14275 1677500
#> 14276 1677501
#> 14277 1677502
#> 14278 1677503
#> 14279 1677504
#> 14280 1677505
#> 14281 1677506
#> 14282 1677509
#> 14283 1677518
#> 14284 1677519
#> 14285 1677520
#> 14286 1677522
#> 14287 1677783
#> 14288 1677979
#> 14289 1677981
#> 14290 1678666
#> 14291 1679880
#> 14292 1679884
#> 14293 1679885
#> 14294 1680004
#> 14295 1680076
#> 14296 1680924
#> 14297 1681125
#> 14298 1681126
#> 14299 1681127
#> 14300 1681128
#> 14301 1682634
#> 14302 1682724
#> 14303 1682727
#> 14304 1682728
#> 14305 1682729
#> 14306 1682790
#> 14307 1682793
#> 14308 1682794
#> 14309 1682795
#> 14310 1682798
#> 14311 1682831
#> 14312 1682910
#> 14313 1682911
#> 14314 1682912
#> 14315 1682913
#> 14316 1682914
#> 14317 1682915
#> 14318 1682916
#> 14319 1682917
#> 14320 1682918
#> 14321 1682919
#> 14322 1682922
#> 14323 1683019
#> 14324 1683020
#> 14325 1683021
#> 14326 1683022
#> 14327 1683040
#> 14328 1683108
#> 14329 1683176
#> 14330 1683177
#> 14331 1683179
#> 14332 1683180
#> 14333 1683183
#> 14334 1683185
#> 14335 1683186
#> 14336 1683189
#> 14337 1683190
#> 14338 1683193
#> 14339 1683196
#> 14340 1683197
#> 14341 1683443
#> 14342 1683444
#> 14343 1683445
#> 14344 1683446
#> 14345 1683447
#> 14346 1683448
#> 14347 1683449
#> 14348 1683450
#> 14349 1683451
#> 14350 1683452
#> 14351 1683453
#> 14352 1683454
#> 14353 1683455
#> 14354 1683456
#> 14355 1683457
#> 14356 1684497
#> 14357 1684592
#> 14358 1686066
#> 14359 1686069
#> 14360 1686070
#> 14361 1686598
#> 14362 1686601
#> 14363 1686691
#> 14364 1688236
#> 14365 1688237
#> 14366 1689067
#> 14367 1689072
#> 14368 1689073
#> 14369 1689074
#> 14370 1689075
#> 14371 1689076
#> 14372 1689077
#> 14373 1689078
#> 14374 1689079
#> 14375 1689080
#> 14376 1689081
#> 14377 1689082
#> 14378 1689083
#> 14379 1689084
#> 14380 1689085
#> 14381 1689086
#> 14382 1689091
#> 14383 1689092
#> 14384 1689093
#> 14385 1689094
#> 14386 1689095
#> 14387 1689096
#> 14388 1689097
#> 14389 1689098
#> 14390 1689107
#> 14391 1689778
#> 14392 1689796
#> 14393 1689800
#> 14394 1690589
#> 14395 1690591
#> 14396 1690602
#> 14397 1690603
#> 14398 1690604
#> 14399 1690605
#> 14400 1690607
#> 14401 1690608
#> 14402 1690609
#> 14403 1690610
#> 14404 1690611
#> 14405 1690612
#> 14406 1690613
#> 14407 1690618
#> 14408 1690801
#> 14409 1691237
#> 14410 1691240
#> 14411 1691244
#> 14412 1691248
#> 14413 1691252
#> 14414 1691257
#> 14415 1691261
#> 14416 1691265
#> 14417 1691553
#> 14418 1692249
#> 14419 1692469
#> 14420 1693359
#> 14421 1693647
#> 14422 1693845
#> 14423 1693848
#> 14424 1693983
#> 14425 1694031
#> 14426 1694032
#> 14427 1694033
#> 14428 1694034
#> 14429 1694035
#> 14430 1694036
#> 14431 1694039
#> 14432 1694124
#> 14433 1694242
#> 14434 1694244
#> 14435 1694245
#> 14436 1694246
#> 14437 1694247
#> 14438 1694248
#> 14439 1694249
#> 14440 1694250
#> 14441 1694251
#> 14442 1694252
#> 14443 1694253
#> 14444 1694254
#> 14445 1694255
#> 14446 1694256
#> 14447 1694257
#> 14448 1694258
#> 14449 1694259
#> 14450 1694260
#> 14451 1694261
#> 14452 1694262
#> 14453 1694263
#> 14454 1694264
#> 14455 1694265
#> 14456 1694266
#> 14457 1694268
#> 14458 1694269
#> 14459 1694300
#> 14460 1694343
#> 14461 1694905
#> 14462 1694945
#> 14463 1695017
#> 14464 1695083
#> 14465 1695300
#> 14466 1695397
#> 14467 1695602
#> 14468 1696476
#> 14469 1696592
#> 14470 1696720
#> 14471 1697174
#> 14472 1697876
#> 14473 1698639
#> 14474 1699009
#> 14475 1699011
#> 14476 1699045
#> 14477 1699052
#> 14478 1699053
#> 14479 1699178
#> 14480 1699179
#> 14481 1699286
#> 14482 1699496
#> 14483 1700000
#> 14484 1700145
#> 14485 1700146
#> 14486 1700147
#> 14487 1700148
#> 14488 1700149
#> 14489 1700150
#> 14490 1700151
#> 14491 1700152
#> 14492 1700153
#> 14493 1700154
#> 14494 1700155
#> 14495 1700168
#> 14496 1700169
#> 14497 1701037
#> 14498 1701222
#> 14499 1701510
#> 14500 1701938
#> 14501 1701960
#> 14502 1701961
#> 14503 1701988
#> 14504 1701989
#> 14505 1701990
#> 14506 1702586
#> 14507 1702932
#> 14508 1702942
#> 14509 1702952
#> 14510 1702962
#> 14511 1702972
#> 14512 1703215
#> 14513 1703284
#> 14514 1703387
#> 14515 1704305
#> 14516 1704388
#> 14517 1704389
#> 14518 1704390
#> 14519 1704493
#> 14520 1704631
#> 14521 1704654
#> 14522 1704670
#> 14523 1705700
#> 14524 1705711
#> 14525 1706104
#> 14526 1706105
#> 14527 1706109
#> 14528 1706124
#> 14529 1706125
#> 14530 1706126
#> 14531 1706127
#> 14532 1706128
#> 14533 1706137
#> 14534 1706138
#> 14535 1706141
#> 14536 1706475
#> 14537 1707043
#> 14538 1707198
#> 14539 1707203
#> 14540 1707214
#> 14541 1707242
#> 14542 1708502
#> 14543 1708503
#> 14544 1708507
#> 14545 1708939
#> 14546 1709300
#> 14547 1709301
#> 14548 1709302
#> 14549 1709727
#> 14550 1709734
#> 14551 1709735
#> 14552 1709736
#> 14553 1709737
#> 14554 1709738
#> 14555 1709739
#> 14556 1709740
#> 14557 1709741
#> 14558 1709742
#> 14559 1709743
#> 14560 1709744
#> 14561 1709745
#> 14562 1709746
#> 14563 1709747
#> 14564 1709748
#> 14565 1709749
#> 14566 1709750
#> 14567 1709751
#> 14568 1709752
#> 14569 1709753
#> 14570 1709754
#> 14571 1709756
#> 14572 1709759
#> 14573 1709762
#> 14574 1709786
#> 14575 1709787
#> 14576 1709799
#> 14577 1709800
#> 14578 1709837
#> 14579 1709838
#> 14580 1709839
#> 14581 1709840
#> 14582 1709841
#> 14583 1709842
#> 14584 1709843
#> 14585 1709844
#> 14586 1709845
#> 14587 1709846
#> 14588 1709847
#> 14589 1709848
#> 14590 1709849
#> 14591 1709850
#> 14592 1709851
#> 14593 1709852
#> 14594 1709853
#> 14595 1709854
#> 14596 1709855
#> 14597 1710777
#> 14598 1711505
#> 14599 1711798
#> 14600 1711841
#> 14601 1713024
#> 14602 1713144
#> 14603 1713253
#> 14604 1713596
#> 14605 1713720
#> 14606 1714143
#> 14607 1714144
#> 14608 1714145
#> 14609 1714146
#> 14610 1714149
#> 14611 1714150
#> 14612 1714151
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#> 15442 1835833To aggregate concise bioactivity data from each AID:
result <- get_pug_rest(identifier = "79900", namespace = "aid", domain = "assay", operation = "concise", output = "JSON")
result
#>
#> An object of class 'PugRestInstance'
#>
#> Request Details:
#> - Domain: Assay
#> - Namespace: AID
#> - Operation: concise
#> - Identifier: 79900
#>
#> NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database.
#> See ?pubChemData for details.pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#> [1] "AID" "SID" "CID"
#> [4] "Activity Outcome" "Target Accession" "Target GeneID"
#> [7] "Activity Value [uM]" "Activity Name" "Assay Name"
#> [10] "Assay Type" "PubMed ID" "RNAi"
#>
#>
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#> [1] "79900"
#> [2] "103416777"
#> [3] "6476829"
#> [4] "Active"
#> [5] ""
#> [6] ""
#> [7] "0.162"
#> [8] "EC50"
#> [9] "Tested for antirhinoviral activity of compound against HRV 25 infected H1HeLa cells; Cytotoxicity at > 10 uM"
#> [10] "Confirmatory"
#> [11] "11858991"
#> [12] ""These methods provide an efficient and targeted approach to access and analyze cell line-related data in PubChem, supporting a wide range of research applications in cellular biology, pharmacology, and related fields.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.