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1. Introduction

The PubChemR package introduces a pivotal function, get_pug_rest, designed to facilitate seamless access to the vast chemical data repository of PubChem. This function leverages the capabilities of PubChem’s Power User Gateway (PUG) REST service, providing a straightforward and efficient means for users to programmatically interact with PubChem’s extensive database. This vignette aims to elucidate the structure and usage of the PUG REST service, offering a range of illustrative use cases to aid new users in understanding its operation and constructing effective requests.

2. PUG REST: A Gateway to Chemical Data

PUG REST, standing for Power User Gateway RESTful interface, is a simplified access route to PubChem’s data and services. It is designed for scripts, web page embedded JavaScript, and third-party applications, eliminating the need for the more complex XML and SOAP envelopes required by other PUG variants. PUG REST’s design revolves around the PubChem identifier (SID for substances, CID for compounds, and AID for assays) and is structured into three main request components: input (identifiers), operation (actions on identifiers), and output (desired information format).

2.1. Key Features of PUG REST:

  • Flexibility and Combinatorial Use: PUG REST allows a wide range of combinations of inputs, operations, and outputs, enabling users to create customized requests.
  • Support for Various Formats: It supports multiple output formats, including XML, JSON, CSV, PNG, and plain text, catering to different application needs.
  • RESTful Design: The service is based on HTTP requests with details encoded in the URL path, making it RESTful and user-friendly.

Usage Policy:

  • PUG REST is not intended for extremely high-volume requests (millions). Users are advised to limit their requests to no more than 5 per second to prevent server overload.
  • For large data sets, users are encouraged to contact PubChem for optimized query approaches.

3. Accessing PUG REST with get_pug_rest

Overview

The get_pug_rest function in the PubChemR package provides a versatile interface to access a wide range of chemical data from the PubChem database. This section of the vignette focuses on various methods to retrieve chemical structure information and other related data using the PUG REST service. The function is designed to be flexible, accommodating different input methods, operations, and output formats.

This function sends a request to the PubChem PUG REST API to retrieve various types of data for a given identifier. It supports fetching data in different formats and allows saving the output.

get_pug_rest(
  identifier = NULL,
  namespace = "cid",
  domain = "compound",
  operation = NULL,
  output = "JSON",
  searchtype = NULL,
  property = NULL,
  options = NULL,
  save = FALSE,
  dpi = 300,
  path = NULL,
  file_name = NULL,
  ...
)

Arguments

  • identifier: A vector of identifiers for the query, either numeric or character. This is the main input for querying the PubChem database.

  • namespace: A character string specifying the namespace for the request. Default is ‘cid’. This defines the type of identifier being used, such as ‘cid’ (Compound ID), ‘sid’ (Substance ID), etc.

  • domain: A character string specifying the domain for the request. Default is ‘compound’. This indicates the type of entity being queried, such as ‘compound’, ‘substance’, etc.

  • operation: An optional character string specifying the operation for the request. This can be used to specify particular actions or methods within the API.

  • output: A character string specifying the output format. Possible values are ‘SDF’, ‘JSON’, ‘JSONP’, ‘CSV’, ‘TXT’, and ‘PNG’. Default is ‘JSON’. This defines the format in which the data will be returned.

  • searchtype: An optional character string specifying the search type. This allows for specifying the nature of the search being performed.

  • property: An optional character string specifying the property for the request. This can be used to filter or specify particular properties of the data being retrieved.

  • options: A list of additional options for the request. This allows for further customization and fine-tuning of the request parameters.

  • save: A logical value indicating whether to save the output as a file or image. Default is FALSE. When set to TRUE, the function will save the retrieved data to a specified file.

  • dpi: An integer specifying the DPI for image output. Default is 300. This is relevant when the output format is an image, determining the resolution of the saved image.

  • path: A character string specifying the directory path where the file will be saved. If not provided, the current working directory is used.

  • file_name: A character string of length 1. Defines the name of the file (without file extension) to save. If NULL, the default file name is set as “files_downloaded”.

  • : Additional arguments to be passed to the request.

Value

The function returns different types of content based on the specified output format:

JSON: Returns a list. CSV and TXT: Returns a data frame. SDF: Returns an SDF file of the requested identifier. PNG: Returns an image object or saves an image file.

3.1. Input Methods

In the context of the PubChem PUG REST API, the input methods define how records of interest are specified for a request. There are several ways to define this input, with the most common methods being outlined below:

1. By Identifier: The most straightforward method to specify input is by using identifiers directly. These identifiers can be Substance IDs (SIDs) or Compound IDs (CIDs). For example, to retrieve the names of a substance with CID 2244, you can use the get_pug_rest function as follows:

result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: CID
#>   - Operation: <NULL>
#>   - Identifier: 2244
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

The pubChemData function then processes the result to extract and display the retrieved data. Here’s an interpretation of the output for CID 2244:

pubChemDataResult <- pubChemData(result)

The JSON response contains detailed information about the compound identified by CID 2244. The PC_Compounds array holds the compound data, and within it, each element corresponds to a specific compound.

For CID 2244, the following information is retrieved:

ID: Confirms the compound identifier is CID 2244.

pubChemDataResult$PC_Compounds[[1]]$id
#> $id
#>  cid 
#> 2244

Atoms: Details the atomic composition, with an aid array listing the atom IDs and an element array listing the atomic numbers (e.g., 6 for carbon, 8 for oxygen, 1 for hydrogen).

pubChemDataResult$PC_Compounds[[1]]$atoms
#> $aid
#>  [1]  1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21
#> 
#> $element
#>  [1] 8 8 8 8 6 6 6 6 6 6 6 6 6 1 1 1 1 1 1 1 1

Bonds: Describes the bonds between atoms, including arrays for the IDs of the atoms involved (aid1 and aid2) and the bond order.

pubChemDataResult$PC_Compounds[[1]]$bonds
#> $aid1
#>  [1]  1  1  2  2  3  4  5  5  6  6  7  7  8  8  9  9 10 12 13 13 13
#> 
#> $aid2
#>  [1]  5 12 11 21 11 12  6  7  8 11  9 14 10 15 10 16 17 13 18 19 20
#> 
#> $order
#>  [1] 1 1 1 1 2 2 1 2 2 1 1 1 1 1 2 1 1 1 1 1 1

Coordinates: Provides the spatial coordinates (x and y) for each atom, which can be used to visualize the molecular structure.

pubChemDataResult$PC_Compounds[[1]]$coords
#> [[1]]
#> [[1]]$type
#> [1]   1   5 255
#> 
#> [[1]]$aid
#>  [1]  1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21
#> 
#> [[1]]$conformers
#> [[1]]$conformers[[1]]
#> [[1]]$conformers[[1]]$x
#>  [1] 3.7320 6.3301 4.5981 2.8660 4.5981 5.4641 4.5981 6.3301 5.4641 6.3301
#> [11] 5.4641 2.8660 2.0000 4.0611 6.8671 5.4641 6.8671 2.3100 1.4631 1.6900
#> [21] 6.3301
#> 
#> [[1]]$conformers[[1]]$y
#>  [1] -0.0600  1.4400  1.4400 -1.5600 -0.5600 -0.0600 -1.5600 -0.5600 -2.0600
#> [10] -1.5600  0.9400 -0.5600 -0.0600 -1.8700 -0.2500 -2.6800 -1.8700  0.4769
#> [19]  0.2500 -0.5969  2.0600
#> 
#> [[1]]$conformers[[1]]$style
#> [[1]]$conformers[[1]]$style$annotation
#> [1] 8 8 8 8 8 8
#> 
#> [[1]]$conformers[[1]]$style$aid1
#> [1] 5 5 6 7 8 9
#> 
#> [[1]]$conformers[[1]]$style$aid2
#> [1]  6  7  8  9 10 10

Charge: Indicates the compound’s charge, which is 0 in this case.

pubChemDataResult$PC_Compounds[[1]]$charge
#> [1] 0

Properties: Lists various properties of the compound, including:

Compound Complexity: A measure of the molecular complexity.

pubChemDataResult$PC_Compounds[[1]]$props[[2]]
#> $urn
#> $urn$label
#> [1] "Compound Complexity"
#> 
#> $urn$datatype
#> [1] 7
#> 
#> $urn$implementation
#> [1] "E_COMPLEXITY"
#> 
#> $urn$version
#> [1] "3.4.8.18"
#> 
#> $urn$software
#> [1] "Cactvs"
#> 
#> $urn$source
#> [1] "Xemistry GmbH"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#> fval 
#>  212

Hydrogen Bond Acceptor/Donor Count: Indicates the number of hydrogen bond acceptors and donors.

pubChemDataResult$PC_Compounds[[1]]$props[[3]]
#> $urn
#> $urn$label
#> [1] "Count"
#> 
#> $urn$name
#> [1] "Hydrogen Bond Acceptor"
#> 
#> $urn$datatype
#> [1] 5
#> 
#> $urn$implementation
#> [1] "E_NHACCEPTORS"
#> 
#> $urn$version
#> [1] "3.4.8.18"
#> 
#> $urn$software
#> [1] "Cactvs"
#> 
#> $urn$source
#> [1] "Xemistry GmbH"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#> ival 
#>    4
pubChemDataResult$PC_Compounds[[1]]$props[[4]]
#> $urn
#> $urn$label
#> [1] "Count"
#> 
#> $urn$name
#> [1] "Hydrogen Bond Donor"
#> 
#> $urn$datatype
#> [1] 5
#> 
#> $urn$implementation
#> [1] "E_NHDONORS"
#> 
#> $urn$version
#> [1] "3.4.8.18"
#> 
#> $urn$software
#> [1] "Cactvs"
#> 
#> $urn$source
#> [1] "Xemistry GmbH"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#> ival 
#>    1

Rotatable Bond Count: The number of rotatable bonds, which impacts the molecule’s flexibility.

pubChemDataResult$PC_Compounds[[1]]$props[[5]]
#> $urn
#> $urn$label
#> [1] "Count"
#> 
#> $urn$name
#> [1] "Rotatable Bond"
#> 
#> $urn$datatype
#> [1] 5
#> 
#> $urn$implementation
#> [1] "E_NROTBONDS"
#> 
#> $urn$version
#> [1] "3.4.8.18"
#> 
#> $urn$software
#> [1] "Cactvs"
#> 
#> $urn$source
#> [1] "Xemistry GmbH"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#> ival 
#>    3

IUPAC Names: Various standardized names for the compound, such as “2-acetoxybenzoic acid” and “2-acetyloxybenzoic acid”.

pubChemDataResult$PC_Compounds[[1]]$props[[7]]
#> $urn
#> $urn$label
#> [1] "IUPAC Name"
#> 
#> $urn$name
#> [1] "Allowed"
#> 
#> $urn$datatype
#> [1] 1
#> 
#> $urn$version
#> [1] "2.7.0"
#> 
#> $urn$software
#> [1] "Lexichem TK"
#> 
#> $urn$source
#> [1] "OpenEye Scientific Software"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#>                    sval 
#> "2-acetoxybenzoic acid"

InChI and InChIKey: Standardized identifiers for the chemical structure.

pubChemDataResult$PC_Compounds[[1]]$props[[13]]
#> $urn
#> $urn$label
#> [1] "InChI"
#> 
#> $urn$name
#> [1] "Standard"
#> 
#> $urn$datatype
#> [1] 1
#> 
#> $urn$version
#> [1] "1.0.6"
#> 
#> $urn$software
#> [1] "InChI"
#> 
#> $urn$source
#> [1] "iupac.org"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#>                                                                   sval 
#> "InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)"
pubChemDataResult$PC_Compounds[[1]]$props[[14]]
#> $urn
#> $urn$label
#> [1] "InChIKey"
#> 
#> $urn$name
#> [1] "Standard"
#> 
#> $urn$datatype
#> [1] 1
#> 
#> $urn$version
#> [1] "1.0.6"
#> 
#> $urn$software
#> [1] "InChI"
#> 
#> $urn$source
#> [1] "iupac.org"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#>                          sval 
#> "BSYNRYMUTXBXSQ-UHFFFAOYSA-N"

Log P: The partition coefficient, indicating the compound’s hydrophobicity.

pubChemDataResult$PC_Compounds[[1]]$props[[15]]
#> $urn
#> $urn$label
#> [1] "Log P"
#> 
#> $urn$name
#> [1] "XLogP3"
#> 
#> $urn$datatype
#> [1] 7
#> 
#> $urn$version
#> [1] "3.0"
#> 
#> $urn$source
#> [1] "sioc-ccbg.ac.cn"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#> fval 
#>  1.2

Molecular Formula: The chemical formula of the compound, which is C9H8O4.

pubChemDataResult$PC_Compounds[[1]]$props[[17]]
#> $urn
#> $urn$label
#> [1] "Molecular Formula"
#> 
#> $urn$datatype
#> [1] 1
#> 
#> $urn$version
#> [1] "2.2"
#> 
#> $urn$software
#> [1] "PubChem"
#> 
#> $urn$source
#> [1] "ncbi.nlm.nih.gov"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#>     sval 
#> "C9H8O4"

Molecular Weight: The compound’s molecular weight, 180.16 g/mol.

pubChemDataResult$PC_Compounds[[1]]$props[[18]]
#> $urn
#> $urn$label
#> [1] "Molecular Weight"
#> 
#> $urn$datatype
#> [1] 1
#> 
#> $urn$version
#> [1] "2.2"
#> 
#> $urn$software
#> [1] "PubChem"
#> 
#> $urn$source
#> [1] "ncbi.nlm.nih.gov"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#>     sval 
#> "180.16"

SMILES: Canonical and isomeric Simplified Molecular Input Line Entry System (SMILES) strings, which are text representations of the chemical structure. Topological Polar Surface Area: A measure of the molecule’s surface area that can form hydrogen bonds.

pubChemDataResult$PC_Compounds[[1]]$props[[19]]
#> $urn
#> $urn$label
#> [1] "SMILES"
#> 
#> $urn$name
#> [1] "Canonical"
#> 
#> $urn$datatype
#> [1] 1
#> 
#> $urn$version
#> [1] "2.3.0"
#> 
#> $urn$software
#> [1] "OEChem"
#> 
#> $urn$source
#> [1] "OpenEye Scientific Software"
#> 
#> $urn$release
#> [1] "2021.10.14"
#> 
#> 
#> $value
#>                       sval 
#> "CC(=O)OC1=CC=CC=C1C(=O)O"

For multiple IDs, a vector of IDs can be used. For instance, to retrieve a CSV table of compound properties:

result <- get_pug_rest(identifier = c("1","2","3","4","5"), namespace = "cid", domain = "compound", property = c("MolecularFormula","MolecularWeight","CanonicalSMILES"), output = "CSV")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: CID
#>   - Operation: <NULL>
#>   - Identifier: 1, 2, ... and 3 more.
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

The output of this request, when processed with pubChemData, provides a data frame containing the specified properties for each CID:

pubChemData(result)
#>   CID MolecularFormula MolecularWeight                  CanonicalSMILES
#> 1   1         C9H17NO4          203.24 CC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
#> 2   2        C9H18NO4+          204.24    CC(=O)OC(CC(=O)O)C[N+](C)(C)C
#> 3   3           C7H8O4          156.14         C1=CC(C(C(=C1)C(=O)O)O)O
#> 4   4           C3H9NO           75.11                          CC(CN)O
#> 5   5         C3H8NO5P          169.07             C(C(=O)COP(=O)(O)O)N

Each row in the table corresponds to a different CID and lists the requested properties, facilitating easy comparison and further analysis.

2. By Name: In addition to using direct identifiers, you can refer to a chemical by its common name. This method allows users to search for compounds using familiar names instead of numerical identifiers. It’s important to note that a single name might correspond to multiple records in the PubChem database. For example, the name “glucose” can refer to several different compounds or isomers. Here’s how you can retrieve Compound IDs (CIDs) for “glucose”:

result <- get_pug_rest(identifier = "glucose", namespace = "name", domain = "compound", operation = "cids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: Name
#>   - Operation: cids
#>   - Identifier: glucose
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

The pubChemData function is then used to process the result and extract the retrieved data. The function retrieves the output in data frame. The output indicates that the search for “glucose” returned a single CID:

pubChemData(result)
#>   Text
#> 1 5793

This output reveals that the common name “glucose” corresponds to the CID 5793. This CID can then be used in further queries to retrieve detailed information about the compound, such as its molecular structure, properties, and associated bioactivities.

Using a common name for searching can simplify the process, especially when the numerical identifiers are not known. However, because a name can map to multiple records, the results might need further filtering or validation to ensure they correspond to the specific compound of interest.

3. By Structure Identity: Another method to specify a compound in PubChem PUG REST API requests is by using structural identifiers such as SMILES or InChI keys. This approach allows for precise identification of chemical structures by providing a textual representation of the molecule. For example, to retrieve the CID for the SMILES string “CCCC” (which represents butane), you can use the following code:

result <- get_pug_rest(identifier = "CCCC", namespace = "smiles", domain = "compound", operation = "cids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: SMILES
#>   - Operation: cids
#>   - Identifier: CCCC
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

When the pubChemData(result) function is executed, it retrieves the output in data frame. The output indicates that the search for the SMILES string “CCCC” returned a single CID:

pubChemData(result)
#>   Text
#> 1 7843

This output reveals that the SMILES string “CCCC” corresponds to the CID 7843. This CID can then be used in further queries to gather detailed information about the compound, such as its molecular structure, physical and chemical properties, biological activities, and more.

Using structure-based identifiers like SMILES or InChI keys is particularly useful for precise and unambiguous chemical searches, as these identifiers provide a detailed representation of the molecule’s structure. This method ensures that the exact compound of interest is identified, reducing the risk of ambiguity that might arise with common names or other identifiers.

4. By Fast (Synchronous) Structure Search: In PubChem PUG REST API, fast (synchronous) structure search allows for quicker searches by identity, similarity, substructure, and superstructure, often returning results in a single call. This method is efficient for obtaining results quickly and is useful for various types of structural queries.

To illustrate, let’s perform a fast identity search for the compound with CID 5793, using the same connectivity option:

result <- get_pug_rest(identifier = "5793", namespace = "cid", domain = "compound", operation = "cids", output = "TXT", searchtype = "fastidentity", options = list(identity_type = "same_connectivity"))
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: CID
#>   - Operation: cids
#>   - Identifier: 5793
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

When the following code executed, it retrieves the output in data frame, listing all CIDs that match the fast identity search criteria.

pubChemData(result)
#>          Text
#> 1        5793
#> 2         206
#> 3        6036
#> 4       18950
#> 5       64689
#> 6       66371
#> 7       79025
#> 8       81696
#> 9      104724
#> 10     185698
#> 11     439353
#> 12     439357
#> 13     439507
#> 14     439583
#> 15     439680
#> 16     441032
#> 17     441033
#> 18     441034
#> 19     441035
#> 20     444314
#> 21     448388
#> 22     448702
#> 23     451187
#> 24     451188
#> 25     451189
#> 26     452245
#> 27     455147
#> 28     657055
#> 29    1549080
#> 30    2724488
#> 31    3000450
#> 32    3034742
#> 33    5319264
#> 34    6102790
#> 35    6321330
#> 36    6323336
#> 37    6400264
#> 38    6560213
#> 39    6971003
#> 40    6971007
#> 41    6971016
#> 42    6971096
#> 43    6971097
#> 44    6971098
#> 45    6992021
#> 46    6992084
#> 47    7018164
#> 48    7043897
#> 49    7044038
#> 50    7098663
#> 51    7098664
#> 52    7157007
#> 53    9794056
#> 54    9815418
#> 55    9834129
#> 56    9899007
#> 57   10035228
#> 58   10081060
#> 59   10103794
#> 60   10130220
#> 61   10197954
#> 62   10219674
#> 63   10219763
#> 64   10313382
#> 65   10329946
#> 66   10899282
#> 67   10954241
#> 68   11019447
#> 69   11030410
#> 70   11344362
#> 71   11367383
#> 72   11412863
#> 73   11480819
#> 74   11492034
#> 75   11571906
#> 76   11571917
#> 77   11600783
#> 78   11651921
#> 79   11672764
#> 80   11959770
#> 81   11970126
#> 82   12003287
#> 83   12193653
#> 84   12285853
#> 85   12285856
#> 86   12285861
#> 87   12285862
#> 88   12285863
#> 89   12285866
#> 90   12285868
#> 91   12285869
#> 92   12285870
#> 93   12285871
#> 94   12285873
#> 95   12285877
#> 96   12285878
#> 97   12285879
#> 98   12285885
#> 99   12285886
#> 100  12285889
#> 101  12285890
#> 102  12285891
#> 103  12285892
#> 104  12285893
#> 105  12285894
#> 106  16054987
#> 107  16211884
#> 108  16211941
#> 109  16211984
#> 110  16211986
#> 111  16212959
#> 112  16212960
#> 113  16212966
#> 114  16213546
#> 115  16213640
#> 116  16213872
#> 117  16217112
#> 118  16219580
#> 119  21355827
#> 120  22825318
#> 121  22836365
#> 122  22836366
#> 123  23424086
#> 124  24728695
#> 125  24802149
#> 126  24802163
#> 127  24802281
#> 128  24892722
#> 129  42626680
#> 130  44328781
#> 131  44328785
#> 132  46188479
#> 133  46780441
#> 134  46897877
#> 135  50939543
#> 136  51340651
#> 137  54445181
#> 138  54445182
#> 139  56845432
#> 140  56845995
#> 141  57197748
#> 142  57288387
#> 143  57483528
#> 144  57691826
#> 145  57973135
#> 146  58070804
#> 147  58265153
#> 148  58265160
#> 149  58265166
#> 150  58265178
#> 151  58265190
#> 152  58265196
#> 153  58300638
#> 154  58594768
#> 155  58595959
#> 156  58618581
#> 157  58969552
#> 158  59034276
#> 159  59036328
#> 160  59040622
#> 161  59083882
#> 162  59105109
#> 163  59125088
#> 164  59146659
#> 165  59383280
#> 166  59445439
#> 167  59503407
#> 168  59503411
#> 169  59886072
#> 170  59965103
#> 171  60052896
#> 172  60078648
#> 173  66629908
#> 174  67518639
#> 175  67615000
#> 176  67615455
#> 177  67641738
#> 178  67938791
#> 179  67944215
#> 180  67944290
#> 181  67950444
#> 182  68167579
#> 183  68324677
#> 184  68334110
#> 185  69528681
#> 186  70443535
#> 187  70543261
#> 188  71309028
#> 189  71309128
#> 190  71309129
#> 191  71309140
#> 192  71309397
#> 193  71309503
#> 194  71309513
#> 195  71309514
#> 196  71309671
#> 197  71309852
#> 198  71309905
#> 199  71309908
#> 200  71309927
#> 201  71317094
#> 202  71317095
#> 203  71317096
#> 204  71317097
#> 205  71317182
#> 206  71777654
#> 207  75357255
#> 208  76973265
#> 209  86278404
#> 210  87297824
#> 211  87929779
#> 212  87931119
#> 213  88255060
#> 214  88547603
#> 215  88974141
#> 216  89000581
#> 217  89200515
#> 218  89332529
#> 219  89374440
#> 220  89424182
#> 221  89742272
#> 222  89855666
#> 223  90057933
#> 224  90159939
#> 225  90346255
#> 226  90470917
#> 227  90472751
#> 228  90472752
#> 229  90472753
#> 230  90472761
#> 231  90472762
#> 232  90472770
#> 233  90473076
#> 234  90781811
#> 235  90895196
#> 236  91057721
#> 237  92043367
#> 238  92043446
#> 239 101015849
#> 240 101033892
#> 241 101254308
#> 242 101254309
#> 243 101254310
#> 244 101254311
#> 245 101254312
#> 246 101254313
#> 247 101254314
#> 248 101254315
#> 249 101469918
#> 250 101513786
#> 251 101718250
#> 252 101718251
#> 253 101796201
#> 254 102089288
#> 255 102447462
#> 256 102447463
#> 257 102601142
#> 258 102601177
#> 259 102601371
#> 260 102601743
#> 261 102601816
#> 262 117064633
#> 263 117064644
#> 264 117065485
#> 265 117633116
#> 266 117768413
#> 267 117938207
#> 268 118797420
#> 269 118797610
#> 270 118797621
#> 271 118797622
#> 272 118855887
#> 273 118855889
#> 274 118855904
#> 275 118855910
#> 276 118855920
#> 277 118855925
#> 278 118924468
#> 279 121494046
#> 280 121494058
#> 281 122360911
#> 282 122522140
#> 283 125309563
#> 284 125353406
#> 285 126704391
#> 286 129629038
#> 287 131698424
#> 288 131698425
#> 289 131698450
#> 290 131699179
#> 291 131842051
#> 292 131966764
#> 293 132939819
#> 294 132939820
#> 295 133119158
#> 296 133119249
#> 297 133121364
#> 298 133662560
#> 299 133662561
#> 300 133662562
#> 301 134695353
#> 302 134860471
#> 303 136898365
#> 304 137554722
#> 305 139025182
#> 306 140565377
#> 307 141697522
#> 308 142119910
#> 309 145874935
#> 310 153238571
#> 311 153238579
#> 312 154008122
#> 313 154724068
#> 314 155920671
#> 315 156615593
#> 316 162642814
#> 317 166450901
#> 318 166606713
#> 319 168357285
#> 320 168358828
#> 321 168361185
#> 322 168361364
#> 323 168361934
#> 324 168362043
#> 325 168363258
#> 326 168364204
#> 327 168365395
#> 328 168365574
#> 329 168366670
#> 330 168371870
#> 331 168372103
#> 332 168375045
#> 333 168375837
#> 334 168375921
#> 335 169440996
#> 336 169440997
#> 337 169493886
#> 338 169493887
#> 339 169494552

The output indicates that there are numerous compounds with similar connectivity to the compound identified by CID 5793. Each row in the output represents a different CID that shares the same connectivity pattern as the original compound. This extensive list includes hundreds of CIDs, showcasing the effectiveness of the fast identity search in identifying structurally related compounds quickly.

This method is advantageous for researchers needing to identify compounds with similar structures for further study, such as drug development, chemical analysis, or bioactivity screening. The fast response time and comprehensive results make it a valuable tool for various chemical and pharmaceutical applications.

5. By Cross-Reference (XRef): The cross-reference (XRef) method allows for reverse lookup of records using a cross-reference value. This method is particularly useful for linking external identifiers, such as patent numbers, to records in the PubChem database. For example, to find all SIDs linked to a specific patent identifier, you can use the following code:

result <- get_pug_rest(identifier = "US20050159403A1", namespace = "xref/PatentID", domain = "substance", operation = "sids", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Substance
#>   - Namespace: DomainSpecific
#>   - Operation: sids
#>   - Identifier: US20050159403A1
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

pubChemData function retrieves all SIDs that are linked to the specified patent identifier. The output indicates that the specified patent identifier “US20050159403A1” is linked to a large number of SIDs. Each SID represents a different substance that has been referenced in the patent.

pubChemData(result)
#> $IdentifierList
#> $IdentifierList$SID
#>    [1] 127377127 127382334 127386382 127387376 127394906 127397376 127401897
#>    [8] 127417654 127421022 127427561 127429426 127432264 127440404 127440428
#>   [15] 127445646 127449926 127457867 127460434 127463574 127464134 127494894
#>   [22] 127496937 127498548 127529998 127543991 127546018 127550965 127560184
#>   [29] 127566278 127568614 127579066 127599056 127600815 127611817 127623534
#>   [36] 127625503 127632433 127671807 127679107 127688846 127691718 127697988
#>   [43] 127711332 127715174 127721611 127722233 127724090 127724974 127727269
#>   [50] 127740859 127774458 127786062 127790664 127793921 127794507 127795243
#>   [57] 127815192 127824113 127825299 127832880 127835824 127841389 127851147
#>   [64] 127855878 127884538 127887083 127907515 127915891 127918344 127926702
#>   [71] 127931871 127943403 127949193 127959361 127959362 127961945 127968700
#>   [78] 127974435 127988890 128003687 128016428 128024305 128030061 128033308
#>   [85] 128033392 128037075 128041901 128043208 128054804 128071903 128075872
#>   [92] 128078936 128080424 128086739 128096360 128107971 128108063 128108066
#>   [99] 128112623 128116501 128122481 128133149 128139949 128147430 128149266
#>  [106] 128164707 128171553 128181006 128199891 128202584 128204869 128208747
#>  [113] 128209556 128214152 128216313 128231608 128233622 128235075 128239224
#>  [120] 128247683 128253922 128254582 128257870 128265053 128273912 128287030
#>  [127] 128289228 128292761 128310374 128310447 128311517 128313782 128319875
#>  [134] 128321254 128324845 128327185 128328645 128338633 128344584 128358565
#>  [141] 128360063 128361597 128370060 128375029 128381421 128383506 128383593
#>  [148] 128385126 128390596 128391357 128391640 128397827 128407104 128414752
#>  [155] 128417831 128417970 128421724 128427165 128429151 128431035 128453144
#>  [162] 128454426 128459192 128479099 128485819 128490532 128490533 128496172
#>  [169] 128504855 128514984 128515903 128531133 128539521 128548161 128550853
#>  [176] 128555702 128571383 128573137 128579725 128582246 128587585 128600655
#>  [183] 128620771 128624545 128627105 128628584 128632557 128632828 128633726
#>  [190] 128633902 128634258 128639692 128642692 128646882 128649366 128675326
#>  [197] 128675957 128689052 128690685 128693396 128694828 128699310 128702849
#>  [204] 128706476 128716066 128720357 128723298 128723509 128731938 128749024
#>  [211] 128749163 128751829 128757815 128766098 128776154 128783768 128789021
#>  [218] 128789967 128791547 128796670 128801133 128801849 128804888 128804889
#>  [225] 128808454 128815642 128821150 128833107 128837247 128846910 128856633
#>  [232] 128862719 128865088 128873754 128874253 128880985 128881190 128894056
#>  [239] 128894682 128905743 128908713 128915047 128915536 128921696 128931918
#>  [246] 128934857 128935768 128953776 128955396 128970283 128981506 128988380
#>  [253] 128997690 129001067 129007663 129014483 129015035 129015817 129016179
#>  [260] 129017989 129017990 129026427 129044226 129053129 129054986 129068688
#>  [267] 129068801 129079556 129084855 129102578 129104885 129111825 129113828
#>  [274] 129115030 129122432 129128697 129130686 129133094 129136176 129140081
#>  [281] 129141617 129142896 129148181 129162993 129168398 129173408 129173457
#>  [288] 129176810 129177288 129184645 129192608 129202881 129203714 129205760
#>  [295] 129209673 129218442 129224837 129228814 129233871 129233873 129233874
#>  [302] 129255832 129266266 129272170 129288442 129292073 129294634 129302252
#>  [309] 129309716 129310311 129313799 129317146 129328896 129333065 129337106
#>  [316] 129337589 129345232 129349967 129351897 129359174 129365621 129366270
#>  [323] 129370686 129371805 129374061 129376455 129378267 129379472 129383430
#>  [330] 129384458 129389744 129403822 129421538 129440903 129455218 129456175
#>  [337] 129457573 129462203 129479103 129489229 129493774 129504746 129508593
#>  [344] 129517263 129521307 129526420 129534168 129538802 129547789 129551052
#>  [351] 129551258 129555666 129562150 129573817 129586364 129598381 129614967
#>  [358] 129617515 129624957 129625178 129625510 129627772 129627879 129629301
#>  [365] 129632951 129670298 129672175 129685831 129688258 129702886 129706999
#>  [372] 129709395 129711942 129715311 129726350 129728891 129729719 129736495
#>  [379] 129738647 129764614 129770055 129776398 129781417 129797152 129808214
#>  [386] 129809046 129809280 129811709 129815623 129815624 129818107 129838999
#>  [393] 129842321 129844561 129845709 129855419 129865464 129871639 129873187
#>  [400] 129873949 129879637 129880907 129894085 129894756 129894757 129906668
#>  [407] 129908561 129912020 129921074 129935955 129936330 129941294 129945069
#>  [414] 129950653 129962601 129975648 134359275 134393961 134412235 135747269
#>  [421] 135752889 135754219 135763149 135798297 135802614 135806152 135826617
#>  [428] 135837077 135842328 135847369 135857922 135878265 135887484 135892282
#>  [435] 135900333 135900801 135946050 135971530 136022349 136022812 136044641
#>  [442] 136052383 136057158 136072993 136080169 136099624 136116271 136118214
#>  [449] 136126969 136156103 136157629 136161084 136172216 136222651 136227638
#>  [456] 136234395 136261580 136265581 136269831 136272977 136273523 136275074
#>  [463] 136291195 136291391 136302881 136314053 136324561 136326756 137349406
#>  [470] 137349415 139042442 139667196 140037191 140037194 140254002 140254003
#>  [477] 140254004 140254005 140254006 140254007 140254008 140254009 140254010
#>  [484] 140254011 140254012 140254013 140254014 140254015 140254016 140254017
#>  [491] 140254018 140254019 140254020 140254021 140254022 140254023 140254024
#>  [498] 140254025 140254026 140254027 140254028 140254029 140254030 140254031
#>  [505] 140254032 140254033 140254034 140254035 140254036 140254037 140254038
#>  [512] 140254039 140254040 140254041 140254042 140254043 140254044 140254045
#>  [519] 140254046 140254047 140254048 140254049 140254050 140254051 140254052
#>  [526] 140254053 140254054 140254055 140254056 140254057 140254058 140254059
#>  [533] 140254060 140254061 140254062 140254063 140254064 140254065 140254066
#>  [540] 140254067 140254068 140254069 140254070 140254071 140254072 140254073
#>  [547] 140254074 140254075 140254076 140254077 140254078 140254079 140254080
#>  [554] 140254081 140254082 140254083 140254084 140254085 140254086 140254087
#>  [561] 140254088 140254089 140254090 140254091 140254092 140254093 140254094
#>  [568] 140254095 140254096 140254097 140254098 140254099 140254100 140262425
#>  [575] 140262449 140262456 140262460 140262471 140262478 140262480 140262481
#>  [582] 140262486 140262491 140262504 140297441 140297443 140343485 140343488
#>  [589] 140343490 140343491 140343493 140343497 140343499 140343505 140492225
#>  [596] 141972099 141972100 141989468 142047558 142047559 142059950 142086609
#>  [603] 142090637 142093192 142106350 142106351 142106355 142106365 142106373
#>  [610] 142130212 142216111 142266779 142289307 142290035 142292362 142292867
#>  [617] 142300477 142301161 142355996 142359434 142359441 142365242 142395042
#>  [624] 142395064 142396928 142396930 142396931 142398573 142405238 142418631
#>  [631] 142438154 142448656 142456985 142456989 142456990 142456991 142456995
#>  [638] 142457001 142457025 142457027 142457031 142457036 142457040 142457045
#>  [645] 142457053 142457055 142457058 142457059 142457063 142457067 142457072
#>  [652] 142457075 142457076 142457077 142457082 142457086 142457092 142457095
#>  [659] 142457098 142457099 142457106 142457115 142457119 142457130 142457134
#>  [666] 142457138 142457141 142457144 142457146 142457150 142457151 142457164
#>  [673] 142457170 142457176 142457178 142457181 142457183 142457188 142457195
#>  [680] 142457199 142457201 142457202 142457210 142457212 142457213 142457217
#>  [687] 142472709 142504653 142517754 142718650 142794296 142794297 142794298
#>  [694] 142976674 142976694 143004316 143078051 143078053 143078054 143078056
#>  [701] 143078060 143078078 143078326 143091452 143251864 143251865 143251867
#>  [708] 143251868 143251869 143251871 143251875 143251881 143251883 143251885
#>  [715] 143251886 143251887 143251888 143251890 143251892 143251894 143251895
#>  [722] 143274528 143298830 143319100 226393239 226393293 226393570 226393684
#>  [729] 226393819 226393829 226393830 226393853 226393858 226393970 226393971
#>  [736] 226394040 226394128 226394161 226394178 226394363 226394438 226394481
#>  [743] 226394721 226394839 226395300 226395327 226395471 226395557 226395600
#>  [750] 226395667 226395683 226395726 226395777 226395791 226395832 226395919
#>  [757] 226395920 226395976 226395977 226396049 226396167 226396198 226396401
#>  [764] 226396434 226396445 226396464 226396553 226396598 226396617 226396621
#>  [771] 226396627 226397203 226397214 226397352 226397529 226397954 226397955
#>  [778] 226398150 226398151 226398302 226398454 226399315 226399316 226399355
#>  [785] 226399517 226399539 226399589 226400026 226400044 226400188 226400189
#>  [792] 226400247 226400424 226401770 226402238 226405416 226405489 226405836
#>  [799] 226406284 226406322 226406323 226406337 226406377 226406378 226406714
#>  [806] 226406715 226406888 226407848 226408395 226408853 226409030 226409597
#>  [813] 226409697 226410719 226411068 226411348 226411370 226411403 226411806
#>  [820] 226412544 226412844 226412845 226412937 226413104 226413385 226413386
#>  [827] 226413604 226413605 226413606 226414206 226414262 226414263 226414297
#>  [834] 226414324 226419993 226419994 226420042 226420160 226420161 226420292
#>  [841] 226420293 226420456 226420457 226420566 226420567 226420640 226420681
#>  [848] 226420720 226420751 226420773 226420774 226420775 226420787 226420804
#>  [855] 226420877 226421001 226421002 226421003 226421699 226421728 226423326
#>  [862] 226423740 226423826 226424221 226424268 226424269 226424411 226424412
#>  [869] 226424915 226425111 226425112 226425266 226425785 226425786 226425915
#>  [876] 226425916 226426085 226426288 226426344 226426345 226426582 226426623
#>  [883] 226426904 226427860 226427861 226428721 226428722 226428885 226429123
#>  [890] 226429124 226432865 226432866 226433067 226433069 226433070 226433090
#>  [897] 226433091 226433125 226433126 226433141 226433192 226433193 226433202
#>  [904] 226433203 226433344 226433345 226433523 226433524 226433876 226434160
#>  [911] 226434771 226440330 226441562 226443823 226445144 226457181 226457266
#>  [918] 226457330 226457331 226457556 226458114 226458225 226458539 226459695
#>  [925] 226461214 226462543 226471608 226471621 226472159 226472161 226487293
#>  [932] 226487863 226487864 226489321 226490310 226490791 226492265 226492375
#>  [939] 226492435 226492437 226492438 226493640 226494285 226494502 226495017
#>  [946] 226495025 226497342 226503391 226503607 226506442 226506563 226516040
#>  [953] 226520272 226521124 226542800 226553920 226554136 226564914 226567033
#>  [960] 226567034 226567043 226567109 226567110 226567180 226567194 226567379
#>  [967] 226567380 226567400 226567435 226567443 226567450 226567458 226567459
#>  [974] 226567556 226567567 226567574 226567579 226567629 226567646 226567656
#>  [981] 226567670 226567681 226567699 226567701 226567702 226567706 226567717
#>  [988] 226567727 226567759 226567799 226567800 226567820 226567824 226567833
#>  [995] 226567848 226567862 226567886 226567894 226567923 226567935 226567950
#> [1002] 226567961 226567989 226568036 226568060 226568061 226568066 226568082
#> [1009] 226568123 226568127 226568139 226568146 226568177 226568234 226568241
#> [1016] 226568245 226568264 226568294 226568315 226568346 226568349 226568359
#> [1023] 226568362 226568364 226568408 226568416 226568417 226568432 226568449
#> [1030] 226568457 226568460 226568463 226568464 226568465 226568530 226568537
#> [1037] 226568633 226568641 226568645 226568657 226568663 226568670 226568680
#> [1044] 226568696 226568699 226568700 226568701 226568711 226568713 226568725
#> [1051] 226568734 226568738 226568746 226568772 226568798 226568876 226568911
#> [1058] 226568928 226568929 226568941 226568980 226569025 226569064 226569099
#> [1065] 226569118 226569177 226569196 226569204 226569217 226569220 226569226
#> [1072] 226569232 226569328 226569330 226569349 226569414 226569437 226569451
#> [1079] 226569464 226569471 226569516 226569535 226569554 226569573 226569593
#> [1086] 226569594 226569596 226569607 226569623 226569624 226569625 226569648
#> [1093] 226569680 226569683 226569748 226569754 226569769 226569783 226569821
#> [1100] 226569829 226569832 226569836 226569850 226569859 226569892 226569907
#> [1107] 226569908 226569912 226569959 226569976 226569984 226569988 226570060
#> [1114] 226570099 226570146 226570279 226570308 226570330 226570331 226570363
#> [1121] 226570382 226570383 226570483 226570745 226570749 226570755 226570849
#> [1128] 226571011 226573101 226573345 226574052 226574439 226582522 226584018
#> [1135] 226589272 226589273 226597434 226597505 226600715 226600746 226647066
#> [1142] 226648068 226656069 226667895 226668614 226668738 226668855 226669423
#> [1149] 226669639 226670087 226683506 226696380 226710719 226823612 226871249
#> [1156] 226876459 226876460 226936194 226965286 226972501 226973045 226973164
#> [1163] 227122429 227236737 227281952 227325851 227339001 227384742 227409508
#> [1170] 227461168 227461872 227474526 227511968 227511969 227564952 227748570
#> [1177] 227960305 227987782 227988458 227990171 227990458 227991140 228067840
#> [1184] 228093688 228094302 228094400 228094598 228099363 228140626 228159764
#> [1191] 228159766 228248383 228248928 228263743 228265260 228304181 228304246
#> [1198] 228355922 228361147 228452780 228639103 228770559 228770560 228819438
#> [1205] 228821051 228821054 228821055 228821056 228821057 228821058 228821059
#> [1212] 229280318 229294930 229334353 229337219 229634546 230157026 230160664
#> [1219] 230162107 230331623 230331934 230335306 230336805 230336809 230337506
#> [1226] 230337861 230338660 230338865 230922657 231379826 231380229 231380490
#> [1233] 231380595 231408598 231804558 231804593 231804765 231805001 231805228
#> [1240] 231805267 231805479 231805547 231805598 231805601 231805607 232099662
#> [1247] 232168843 242681556 242717650 242881388 242920991 242939316 243086546
#> [1254] 243093644 243247276 243279817 243310463 243530634 243738751 243781361
#> [1261] 243836721 244274765 244304819 244351778 244473144 244482943 244615862
#> [1268] 244627129 244636869 244759771 244861749 245029031 245033760 245283852
#> [1275] 245309404 245363541 245370020 245708899 245712680 245833937 245910951
#> [1282] 246055152 246059618 246152086 246185335 246302557 246328178 246352373
#> [1289] 246554028 246643596 246771767 246837580 246918682 246999746 247221074
#> [1296] 247555200 247576141 247608871 247940116 248042834 248050678 248370740
#> [1303] 248382919 248412763 248454658 248521494 248564737 248603625 248633503
#> [1310] 248880456 248936405 248962580 249096157 406908050 406924010 406974008
#> [1317] 407050344 407246776 407400630 407406725 407454637 407458795 407597864
#> [1324] 407694713 408147735 408215224 408217559 408259874 408364713 408470213
#> [1331] 408624647 408901036 409227565 409282571 409314082 409433585 409471800
#> [1338] 409673423 409688950 409807984 409808036 409844257 409847976 409898992
#> [1345] 409899538 409899617 409900700 409918668 409918859 409956750 410076269
#> [1352] 410111933 410112156 410199016 410250219 410310907 410320935 410358412
#> [1359] 410358870 410358993 410364139 410368205 410390548 410443241 410611603
#> [1366] 410656308 410714557 410730470 410800662 410813610 410878039 410889153
#> [1373] 411029050 411120346 411209812 411236714 411322314 411481111 411739633
#> [1380] 411848723 412068746 412190947 412223907 412476987 412478856 412516310
#> [1387] 412540966 412700950 412759940 412769395 412771380 412892589 413247619
#> [1394] 413431688 413450070 413450927 413457356 413457635 413458038 413458045
#> [1401] 413478250 413485032 413490608 413490982 413505830 413505848 413505864
#> [1408] 413505881 413515875 413516940 413517191 413517594 413517711 413517787
#> [1415] 413518248 413518286 413518452 413555803 413573934 413576342 413577607
#> [1422] 413578969 413583708 413584099 413596608 413598583 413598590 413647181
#> [1429] 413911986 413963852 414064183 414626516 414661397 414825813 414856510
#> [1436] 414892091 414935619 414945852 414956160 415069749 415110648 415136092
#> [1443] 415714536 415727884 415728598 415729189 415729254 415729316 415732559
#> [1450] 415732675 415732908 415732945 415732955 415732961 415732979 415733001
#> [1457] 415733004 415740875 415748816 415748861 415748865 415748910 415749238
#> [1464] 415749262 415749353 415750692 415812290 415816885 415821932 415824540
#> [1471] 415827755 415827762 415828559 415829165 415830681 415835565 415850432
#> [1478] 415850705 415851694 415853441 415855021 415857010 415859316 415871129
#> [1485] 415872890 415873239 415875742 415939267 415966755 415966911 415967507
#> [1492] 416129933 416132545 419476058 419476730 419479763 419480873 419480972
#> [1499] 419485881 419486666 419490957 419491152 419491791 419492671 419492675
#> [1506] 419492924 419493503 419494003 419494133 419494704 419495016 419495902
#> [1513] 419495947 419496295 419497698 419497700 419497832 419499306 419499403
#> [1520] 419499559 419499585 419499632 419499643 419499837 419499846 419499949
#> [1527] 419500086 419500181 419500734 419500914 419501182 419501547 419501734
#> [1534] 419502131 419502930 419503347 419503687 419503883 419503967 419504952
#> [1541] 419505428 419506158 419506282 419506849 419507096 419507450 419507595
#> [1548] 419510089 419512824 419513193 419513201 419513968 419514082 419514092
#> [1555] 419514098 419514102 419514108 419514115 419514117 419516874 419523755
#> [1562] 419524130 419524875 419525381 419526621 419527521 419531719 419531724
#> [1569] 419531750 419531947 419532553 419532839 419534378 419534410 419534469
#> [1576] 419534484 419535046 419535071 419535113 419536034 419536121 419546112
#> [1583] 419549332 419551105 419551195 419551405 419551879 419551899 419551910
#> [1590] 419552498 419553075 419553096 419553297 419554682 419555018 419555613
#> [1597] 419555769 419557728 419559147 419559194 419559505 419561476 419572553
#> [1604] 419574667 419574686 419578517 419585247 419590036 419590658 419590946
#> [1611] 419591129 419591195 419591612 419592226 419593794 419595719 419681507
#> [1618] 419682519 419690476 419700929 419701108 419705795 419714072 419714186
#> [1625] 419721779 419722600 419724974 419742001 419765198 419765456 419968009
#> [1632] 420012827 420028738 420028752 420028796 420028825 420121099 420132130
#> [1639] 420290406 420482162 420509561 420599383 420599583 420611634 420613278
#> [1646] 420625825 420634933 420662981 420668293 420713373 420762856 420764388
#> [1653] 421051216 421054472 421152487 421168189 421185220 421200485 421285150
#> [1660] 421467012 421467021 421467167 421467814 421467821 421467841 421468181
#> [1667] 421618729 421645675 422224723 422286156 422291469 422291508 422291541
#> [1674] 422291868 422294992 422295060 422302674 422302967 422308315 422308547
#> [1681] 422309266 422309809 422319370 422361298 422394972 422395317 422395612
#> [1688] 422397162 422397173 422397290 422423005 422425739 422425747 422425769
#> [1695] 422478595 422511204 422511386 422536544 422536551 422537057 422537069
#> [1702] 422537094 422537110 422537118 422550741 422568394 422568403 422571327
#> [1709] 422571343 422571354 422571402 422573560 422573909 423390419 424119783
#> [1716] 424296317 424306124 424306736 424309010 424309022 424757743 424766567
#> [1723] 424766737 424803005 424818908 424819603 424819823 424819832 424849043
#> [1730] 424877080 425113081 425114186 425165937 425171162 425193155 425312104
#> [1737] 425396324 425516770 425535208 425897534 425961463 425965903 425967206
#> [1744] 426045728 426078961 426089733 426103724 426106692 426108038 426109622
#> [1751] 426110449 426119983 426121923 426147338 426149755 426150549 426150787
#> [1758] 426157394 426159592 426272317 426288672 426294028 426310077 426324267
#> [1765] 426359948 426412333 426432571 426442188 426459973 426517444 427700056
#> [1772] 431577953 432891950 433323349 433323597 433567908 447595048 447853768
#> [1779] 447923060 448050232 448532098 448892836 449326453 449676699 449681106
#> [1786] 449910701 450051033 450232513 450235101 450485725 450532993 450630545
#> [1793] 450682277 451013988 451180599 451555494 451961792 452145594 452311423
#> [1800] 452516785 452986205 453242316 453516563 453664627 453678106 453867505
#> [1807] 453889148 454241035 454274907 454483135 454611257 454631768 456171974
#> [1814] 456295911 456370357 456371022 456411915 456468049 456636612 456671281
#> [1821] 456739466 456796473 456977526 457169682 457192620 457203572 457280508
#> [1828] 457282502 457310819 457311044 457459970 457460012 457584123 457655803
#> [1835] 457673794 457673796 457815268 457842244 458157987 458347242 458392451
#> [1842] 458393276 458393605 458393636 458393652 458393705 458393708 458393785
#> [1849] 458393799 458393801 458394569 458394830 458394859 458394861 458395827
#> [1856] 458396401 458396411 458396423 458397310 458397365 458427722 466349722
#> [1863] 482532917

This result provides a comprehensive list of substances associated with the specified patent, allowing for further exploration and analysis within the PubChem database.

3.2. Available Data

Once you’ve specified the records of interest in PUG REST, the next step is to define what information you want to retrieve about these records. PUG REST excels in providing access to specific data points about each record, such as individual properties or cross-references, without the need to download and sift through large datasets.

1. Full Records: PUG REST allows the retrieval of entire records in various formats like JSON, CSV, TXT, and SDF. For example, to retrieve the record for aspirin (CID 2244) in SDF format:

result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", output = "SDF")

Multiple records can also be requested in a single call, though large lists may be subject to timeouts.

2. Images: Images of chemical structures can be retrieved by specifying PNG format. This works with various input methods, including chemical names, SMILES strings, and InChI keys. For example, to get an image for the chemical name “lipitor”:

get_pug_rest(identifier = "lipitor", namespace = "name", domain = "compound", output = "PNG")
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: Name
#>   - Operation: <NULL>
#>   - Identifier: lipitor
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.

3. Compound Properties: Pre-computed properties for PubChem compounds are accessible individually or in tables. For instance, to get the molecular weight of a compound:

result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", property = "MolecularWeight", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: CID
#>   - Operation: <NULL>
#>   - Identifier: 2244
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>     Text
#> 1 180.16

Or to retrieve a CSV table of multiple compounds and properties:

result <- get_pug_rest(identifier = c("1","2","3","4","5"), namespace = "cid", domain = "compound", property = c("MolecularWeight", "MolecularFormula", "HBondDonorCount", "HBondAcceptorCount", "InChIKey", "InChI"), output = "CSV")
pubChemData(result)
#>   CID MolecularWeight MolecularFormula HBondDonorCount HBondAcceptorCount
#> 1   1          203.24         C9H17NO4               0                  4
#> 2   2          204.24        C9H18NO4+               1                  4
#> 3   3          156.14           C7H8O4               3                  4
#> 4   4           75.11           C3H9NO               2                  2
#> 5   5          169.07         C3H8NO5P               3                  6
#>                      InChIKey
#> 1 RDHQFKQIGNGIED-UHFFFAOYSA-N
#> 2 RDHQFKQIGNGIED-UHFFFAOYSA-O
#> 3 INCSWYKICIYAHB-UHFFFAOYSA-N
#> 4 HXKKHQJGJAFBHI-UHFFFAOYSA-N
#> 5 HIQNVODXENYOFK-UHFFFAOYSA-N
#>                                                                     InChI
#> 1     InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3
#> 2 InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/p+1
#> 3      InChI=1S/C7H8O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,5-6,8-9H,(H,10,11)
#> 4                              InChI=1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3
#> 5             InChI=1S/C3H8NO5P/c4-1-3(5)2-9-10(6,7)8/h1-2,4H2,(H2,6,7,8)

4. Synonyms: To view all synonyms of a compound, such as Vioxx:

result <- get_pug_rest(identifier = "vioxx", namespace = "name", domain = "compound", operation = "synonyms", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: Name
#>   - Operation: synonyms
#>   - Identifier: vioxx
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $InformationList
#> $InformationList$Information
#> $InformationList$Information[[1]]
#> $InformationList$Information[[1]]$CID
#> [1] 5090
#> 
#> $InformationList$Information[[1]]$Synonym
#>   [1] "rofecoxib"                                                  
#>   [2] "162011-90-7"                                                
#>   [3] "Vioxx"                                                      
#>   [4] "Ceoxx"                                                      
#>   [5] "MK 966"                                                     
#>   [6] "4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one"       
#>   [7] "refecoxib"                                                  
#>   [8] "Vioxx Dolor"                                                
#>   [9] "MK-966"                                                     
#>  [10] "4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one"       
#>  [11] "MK0966"                                                     
#>  [12] "4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone"       
#>  [13] "MK 0966"                                                    
#>  [14] "MK-0966"                                                    
#>  [15] "rofecoxibum"                                                
#>  [16] "CCRIS 8967"                                                 
#>  [17] "HSDB 7262"                                                  
#>  [18] "TRM-201"                                                    
#>  [19] "UNII-0QTW8Z7MCR"                                            
#>  [20] "0QTW8Z7MCR"                                                 
#>  [21] "3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one"         
#>  [22] "2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-"     
#>  [23] "NSC-720256"                                                 
#>  [24] "NSC-758705"                                                 
#>  [25] "CHEBI:8887"                                                 
#>  [26] "DTXSID2023567"                                              
#>  [27] "M01AH02"                                                    
#>  [28] "MK966"                                                      
#>  [29] "3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone"       
#>  [30] "4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone"       
#>  [31] "4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone"       
#>  [32] "3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone"      
#>  [33] "4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one"
#>  [34] "CHEMBL122"                                                  
#>  [35] "4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one"         
#>  [36] "DTXCID903567"                                               
#>  [37] "TRM201"                                                     
#>  [38] "NSC720256"                                                  
#>  [39] "NSC 720256"                                                 
#>  [40] "NSC 758705"                                                 
#>  [41] "2(5H)-Furanone, 4-(4-(methylsulfonyl)phenyl)-3-phenyl-"     
#>  [42] "NCGC00095118-01"                                            
#>  [43] "ROFECOXIB (MART.)"                                          
#>  [44] "ROFECOXIB [MART.]"                                          
#>  [45] "Vioxx (trademark)"                                          
#>  [46] "SMR000466331"                                               
#>  [47] "Vioxx (TN)"                                                 
#>  [48] "SR-01000762904"                                             
#>  [49] "3-phenyl-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone"       
#>  [50] "Rofecoxib (JAN/USAN/INN)"                                   
#>  [51] "Rofecoxib [USAN:INN:BAN]"                                   
#>  [52] "Rofecoxib (Vioxx)"                                          
#>  [53] "Rofecoxib [USAN]"                                           
#>  [54] "MFCD00935806"                                               
#>  [55] "KS-1107"                                                    
#>  [56] "MK 0996"                                                    
#>  [57] "Spectrum_000119"                                            
#>  [58] "ROFECOXIB [INN]"                                            
#>  [59] "ROFECOXIB [JAN]"                                            
#>  [60] "SpecPlus_000669"                                            
#>  [61] "ROFECOXIB [MI]"                                             
#>  [62] "ROFECOXIB [HSDB]"                                           
#>  [63] "Spectrum2_000446"                                           
#>  [64] "Spectrum3_001153"                                           
#>  [65] "Spectrum4_000631"                                           
#>  [66] "Spectrum5_001598"                                           
#>  [67] "ROFECOXIB [VANDF]"                                          
#>  [68] "ROFECOXIB [WHO-DD]"                                         
#>  [69] "SCHEMBL3050"                                                
#>  [70] "BSPBio_002705"                                              
#>  [71] "KBioGR_001242"                                              
#>  [72] "KBioGR_002345"                                              
#>  [73] "KBioSS_000559"                                              
#>  [74] "KBioSS_002348"                                              
#>  [75] "MLS000759440"                                               
#>  [76] "MLS001165770"                                               
#>  [77] "MLS001195623"                                               
#>  [78] "MLS001424113"                                               
#>  [79] "MLS006010091"                                               
#>  [80] "BIDD:GT0399"                                                
#>  [81] "DivK1c_006765"                                              
#>  [82] "SPECTRUM1504235"                                            
#>  [83] "SPBio_000492"                                               
#>  [84] "3-(4-methanesulfonylphenyl)-2-phenyl-2-buten-4-olide"       
#>  [85] "GTPL2893"                                                   
#>  [86] "ROFECOXIB [ORANGE BOOK]"                                    
#>  [87] "BDBM22369"                                                  
#>  [88] "KBio1_001709"                                               
#>  [89] "KBio2_000559"                                               
#>  [90] "KBio2_002345"                                               
#>  [91] "KBio2_003127"                                               
#>  [92] "KBio2_004913"                                               
#>  [93] "KBio2_005695"                                               
#>  [94] "KBio2_007481"                                               
#>  [95] "KBio3_002205"                                               
#>  [96] "KBio3_002825"                                               
#>  [97] "EX-A708"                                                    
#>  [98] "cMAP_000024"                                                
#>  [99] "HMS1922H11"                                                 
#> [100] "HMS2051G16"                                                 
#> [101] "HMS2089H20"                                                 
#> [102] "HMS2093E04"                                                 
#> [103] "HMS2232G21"                                                 
#> [104] "HMS3371P11"                                                 
#> [105] "HMS3393G16"                                                 
#> [106] "HMS3651F16"                                                 
#> [107] "HMS3713B07"                                                 
#> [108] "HMS3750I17"                                                 
#> [109] "HMS3885E05"                                                 
#> [110] "Pharmakon1600-01504235"                                     
#> [111] "BCP03619"                                                   
#> [112] "Tox21_111430"                                               
#> [113] "CCG-40253"                                                  
#> [114] "NSC758705"                                                  
#> [115] "s3043"                                                      
#> [116] "STK635144"                                                  
#> [117] "AKOS000280931"                                              
#> [118] "AB07701"                                                    
#> [119] "CS-0997"                                                    
#> [120] "DB00533"                                                    
#> [121] "NC00132"                                                    
#> [122] "SB19518"                                                    
#> [123] "NCGC00095118-02"                                            
#> [124] "NCGC00095118-03"                                            
#> [125] "NCGC00095118-04"                                            
#> [126] "NCGC00095118-05"                                            
#> [127] "NCGC00095118-08"                                            
#> [128] "NCGC00095118-17"                                            
#> [129] "NCGC00095118-18"                                            
#> [130] "AC-28318"                                                   
#> [131] "BR164362"                                                   
#> [132] "HY-17372"                                                   
#> [133] "NCI60_041175"                                               
#> [134] "SBI-0206774.P001"                                           
#> [135] "CAS-162011-90-7"                                            
#> [136] "NS00003940"                                                 
#> [137] "R0206"                                                      
#> [138] "SW219668-1"                                                 
#> [139] "C07590"                                                     
#> [140] "D00568"                                                     
#> [141] "AB00052090-06"                                              
#> [142] "AB00052090-08"                                              
#> [143] "AB00052090_09"                                              
#> [144] "AB00052090_10"                                              
#> [145] "EN300-7364304"                                              
#> [146] "L000912"                                                    
#> [147] "Q411412"                                                    
#> [148] "Q-201676"                                                   
#> [149] "SR-01000762904-3"                                           
#> [150] "SR-01000762904-5"                                           
#> [151] "BRD-K21733600-001-02-6"                                     
#> [152] "BRD-K21733600-001-06-7"                                     
#> [153] "BRD-K21733600-001-14-1"                                     
#> [154] "BRD-K21733600-001-15-8"                                     
#> [155] "BRD-K21733600-001-19-0"                                     
#> [156] "BRD-K21733600-001-23-2"                                     
#> [157] "BRD-K21733600-001-24-0"                                     
#> [158] "3-(4-methanesulfonyl-phenyl)-2-phenyl-2-buten-4-olide"      
#> [159] "4-(4'-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone"      
#> [160] "Z2037279770"                                                
#> [161] "2(5H)-Furanone, 4-[4-(methyl-sulfonyl)phenyl]-3-phenyl-"    
#> [162] "3-(Phenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone"    
#> [163] "3-Phenyl-4-(4-(Methylsulfonyl)Phenyl)-2-(5H)-Furanone"      
#> [164] "4-(4-METHANESULFONYL-PHENYL)-3-PHENYL-5H-FURAN-2-ONE"       
#> [165] "4-(4-methylsulfonylphenyl)-3-phenyl-2,5-dihydro-2-furanone"

5. Cross-References (XRefs): PUG REST provides access to various cross-references. For example, to retrieve MMDB identifiers for protein structures containing aspirin:

result <- get_pug_rest(identifier = "2244", namespace = "cid", domain = "compound", operation = c("xrefs","MMDBID"), output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Compound
#>   - Namespace: CID
#>   - Operation: xrefs
#>   - Identifier: 2244
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $InformationList
#> $InformationList$Information
#> $InformationList$Information[[1]]
#> $InformationList$Information[[1]]$CID
#> [1] 2244
#> 
#> $InformationList$Information[[1]]$MMDBID
#> [1] 115960 173465 230639  27242  27954  54234  70578  75951

Or to find all patent identifiers associated with a given SID:

result <- get_pug_rest(identifier = "137349406", namespace = "sid", domain = "substance", operation = c("xrefs","PatentID"), output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Substance
#>   - Namespace: SID
#>   - Operation: xrefs
#>   - Identifier: 137349406
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>               Text
#> 1  US20030181500A1
#> 2  US20050059720A1
#> 3  US20050124633A1
#> 4  US20050124634A1
#> 5  US20050159403A1
#> 6  US20060008862A1
#> 7  US20060135506A1
#> 8  US20070142442A1
#> 9  US20070179152A1
#> 10 US20070196421A1
#> 11 US20070197957A1
#> 12 US20070198063A1
#> 13 US20070208134A1
#> 14 US20070299043A1
#> 15 US20080125595A1
#> 16 US20090075960A1
#> 17 US20100144696A1
#> 18 US20100144697A1
#> 19 US20100267704A1
#> 20 US20110098273A1
#> 21 US20110177999A1
#> 22 US20110201811A1
#> 23       US7485653
#> 24       US7488721
#> 25       US7585978

These examples illustrate the versatility of PUG REST in fetching specific data efficiently. It’s an ideal tool for users who need quick access to particular pieces of information from the vast PubChem database without the overhead of processing bulk data.

3.3. BioAssays

PubChem BioAssays are complex entities containing a wealth of data. PUG REST provides access to both complete assay records and specific components of BioAssay data, allowing users to efficiently retrieve the information they need.

1. Assay Description: To obtain the description section of a BioAssay, which includes authorship, general description, protocol, and data readout definitions, use a request like:

result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "description", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: description
#>   - Identifier: 504526
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $PC_AssayContainer
#> $PC_AssayContainer[[1]]
#> $PC_AssayContainer[[1]]$assay
#> $PC_AssayContainer[[1]]$assay$descr
#> $PC_AssayContainer[[1]]$assay$descr$aid
#>      id version 
#>  504526       1 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$aid_source
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$name
#> [1] "Southern Research Specialized Biocontainment Screening Center"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$source_id
#>       str 
#> "RSV_DR6" 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$date
#> $PC_AssayContainer[[1]]$assay$descr$aid_source$db$date$std
#>  year month   day 
#>  2012     3    18 
#> 
#> 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$name
#> [1] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$description
#> [1] "Southern Research's Specialized Biocontainment Screening Center (SRSBSC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
#> [2] "Southern Research Institute (Birmingham, Alabama)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
#> [3] "NIH Molecular Libraries Probe Centers Network (MLPCN)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
#> [4] "Assay Provider: Dr. William Severson, Southern Research Institute "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
#> [5] "Grant number:  1 R03 MH082403-01A1"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
#> [6] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
#> [7] "Assay Rationale and Summary:  Currently, there are no commercially available vaccines to protect humans against Respiratory syncytial virus (RSV). RSV is associated with substantial morbidity and mortality and is the most common cause of bronchiolitis and pneumonia among infants and children under one year of age.  Nevertheless, severe lower respiratory tract disease may occur at any age, especially among the elderly or among those with compromised cardiac, pulmonary, or immune systems. The existing therapies for the acute infection are ribavirin and the prophylactic humanized monoclonal antibody (Synagis from MedImmune) that is limited to use in high risk pediatric patients.  The economic impact of RSV infections due to hospitalizations and indirect medical costs is greater than $ 650 million annually.  The assay provider has developed and validated an HTS assay that measures cytopathic effect (CPE) induced in HEp-2 cells by RSV infection, using a luminescent-based detection system for signal endpoint.  We anticipate that the proposed studies utilizing the Molecular Libraries Probes Production Network (MLPCN) HTS resources will generate multiple scaffolds targeting various junctures in the RSV viral lifecycle.  These may be furthered developed into probes to construct novel single or combination therapeutics.  "
#> 
#> $PC_AssayContainer[[1]]$assay$descr$protocol
#>  [1] "Cell Culture: HEp-2 cells (ATCC CCL-23, American Tissue Culture Type) were maintained as adherent cell lines in Optimem 1 with 2 mM L-glutamine and 10% fetal bovine serum (FBS) at 37oC in a humidified 5% CO2 atmosphere. Cells were passaged as needed and harvested from flasks using 0.05% trypsin-EDTA. "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#>  [2] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [3] "Assay Media - Preparation of Complete DMEM/F12: 50 mL Pen/Strep/Glutamine (Gibco, Cat. No. 10378) was added to four liters of room temperature DMEM/F12 (Sigma, Cat. No. D6434) and the pH adjusted to 7.5 using 1N NaOH. The medium was sterile filtered through a 0.2 um filter and 10 mL of HI-FBS was added per 500 mL of media."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
#>  [4] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [5] "RSV culture: Human respiratory syncytial virus (HRSV) strain Long (ATCC VR-26) was used for screening. The RSV stock was prepared in HEp-2 cells using an initial stock obtained from ATCC. Briefly, HEp-2 cells were grown in two T-175 flasks to 50% confluence in Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12 (CDMEM/F12), pH 7.5 with 2.5 mM L-glutamine, 2% FBS and 125 U of penicillin, 125 ug of streptomycin per ml. 0.2 ml of RSV was added to 25 ml of CDMEM/F12. After three days incubation at 37 degrees C, 5% C02 and high humidity, the supernatant was harvested and the cell debris pelleted by centrifuging at 1,000 rpm for 5 minutes at 18 degrees C. Trehalose and FBS were added to a final concentration of 10% each and the supernatant was aliquoted (1 ml per tube) fast freeze using 100% Ethanol dry ice for five minutes and stored at -80 degrees C. These virus stocks were titrated in HEp-2 cells using an agarose overlay plaque method and the titer was 6.0E+07 pfu/ml. "
#>  [6] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [7] "Dose Response Compound Preparation: For dose response screening, compounds or carrier control (DMSO) were diluted to 6x in Complete DMEM/F12. Test compounds were serially diluted 1:2 resulting in an 8 point dose response dilution series. (final plate well concentration ranging from 50 uM to 0.39 uM and a final DMSO concentration of 0.5%). Twenty ul of each dilution was dispensed to assay plates (3% DMSO) in triplicate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
#>  [8] "Control Drug: The positive control drug for this assay, ribavirin [1] (No. 196066, MP Biomedicals, Solon, OH) was solubilized in DMSO. It was diluted and added to the assay plates as described for test compounds. Final concentration for ribavirin was 100uM. All wells contained 0.5% DMSO."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [9] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#> [10] "Preparation of HEp-2 cells: Cells were harvested and resuspended to 178,000 cells per ml in Complete DMEM/F12."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#> [11] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#> [12] "Assay Set up: Sixty ul of HEp-2 cells (10,595 cells/well) forty ul of media and 20 ul of 3% DMSO were plated in the cell control wells. Sixty ul of HEp-2 cells (10,595 cells/well), forty ul of a 1:500 dilution of virus (viral MOI = 0.45) and 20 ul of compound or ribavirin control drug were added to the virus control and compound wells. All cell plating was conducted using a Matrix WellMate and cells were maintained at room temperature with stirring during the plating process. The assay plates were incubated for six days at 37 degrees C, 5% CO2 and 90% relative humidity. "                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [13] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#> [14] "Data Analysis: Eight control wells containing cells only and four wells containing cells and virus were included on each assay plate and used to calculate Z' value for each plate and to normalize the data on a per plate basis.  Results are reported as percent (%) CPE inhibition and were calculated using the following formula: % CPE inhibition = 100*(Test Cmpd - Med Virus)/(Med Cells - Med Virus).  Four ribavirin positive control wells were included on each plate for quality control purposes. To quantify the viral cytopathic effect, IC50s were calculated for each substance using the 4 parameter Levenburg-Marquardt algorithm with the minimum and  maximum parameters locked at 0 and 100, respectively. "                                                                                                                                                                                                                                                                                     
#> 
#> $PC_AssayContainer[[1]]$assay$descr$comment
#> [1] "Possible artifacts in this assay include, but are not limited to, compounds that interfere with the luciferase reaction, absorb luminescence, or precipitate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#> [2] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [3] "Compounds that demonstrated at least 50% inhibition and were considered active. "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [4] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [5] "The following tiered system has been implemented at Southern Research Institute for use with the PubChem Score. Compounds in the primary screen are scored on a scale of 0-40 based on inhibitory activity where a score of 40 corresponds to 100% inhibition. In the initial confirmatory dose response screen, active compounds were scored on a scale of 41-80 based on the IC50 result while compounds that did not confirm as actives were given the score of 0. In assays using purified and synthesized compounds a scale of 81-100 based on the IC50 result is used to denote a high level of confidence in both the substance and the data. Compounds that did not confirm activity were given the score of 0."
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref
#> $PC_AssayContainer[[1]]$assay$descr$xref[[1]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[1]]$xref
#>  aid 
#> 2391 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[1]]$comment
#> [1] "Primary and confirmatory screen."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[2]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[2]]$xref
#>  aid 
#> 2410 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[2]]$comment
#> [1] "Cytotoxicity of primary screen hits."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[3]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[3]]$xref
#>    aid 
#> 449732 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[3]]$comment
#> [1] "TCID50 on selected compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[4]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[4]]$xref
#>    aid 
#> 488972 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[4]]$comment
#> [1] "Confirmatory screen (2) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[5]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[5]]$xref
#>    aid 
#> 488976 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[5]]$comment
#> [1] "Cytotoxicity screen (2) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[6]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[6]]$xref
#>  aid 
#> 2440 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[6]]$comment
#> [1] "Summary AID."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[7]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[7]]$xref
#>    aid 
#> 492966 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[7]]$comment
#> [1] "Confirmatory screen (3) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[8]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[8]]$xref
#>    aid 
#> 492968 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[8]]$comment
#> [1] "Cytotoxicity screen (3) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[9]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[9]]$xref
#>    aid 
#> 493016 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[9]]$comment
#> [1] "Confirmatory screen (4) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[10]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[10]]$xref
#>    aid 
#> 493015 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[10]]$comment
#> [1] "Cytotoxicity screen (4) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[11]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[11]]$xref
#>    aid 
#> 493088 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[11]]$comment
#> [1] "Confirmatory screen (5) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[12]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[12]]$xref
#>    aid 
#> 493090 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[12]]$comment
#> [1] "Cytotoxicity screen (5) on purified and synthesized compounds."
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$xref[[13]]
#> $PC_AssayContainer[[1]]$assay$descr$xref[[13]]$xref
#> taxonomy 
#>    12814 
#> 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$tid
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$name
#> [1] "IC50 Modifier"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$type
#> [1] 4
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[1]]$unit
#> [1] 254
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$tid
#> [1] 2
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$name
#> [1] "IC50"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$unit
#> [1] 5
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[2]]$ac
#> [1] TRUE
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$tid
#> [1] 3
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$name
#> [1] "% CPE Inhibition @ 50 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$description
#> [1] "Inhibition of cytopathic effect of virus at 50 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[3]]$tc
#> concentration          unit         dr_id 
#>            50             5             1 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$tid
#> [1] 4
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$name
#> [1] "% CPE Inhibition @ 25 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$description
#> [1] "Inhibition of cytopathic effect of virus at 25 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[4]]$tc
#> concentration          unit         dr_id 
#>            25             5             1 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$tid
#> [1] 5
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$name
#> [1] "% CPE Inhibition @ 12.5 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$description
#> [1] "Inhibition of cytopathic effect of virus at 12.50 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[5]]$tc
#> concentration          unit         dr_id 
#>          12.5           5.0           1.0 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$tid
#> [1] 6
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$name
#> [1] "% CPE Inhibition @ 6.25 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$description
#> [1] "Inhibition of cytopathic effect of virus at 6.25 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[6]]$tc
#> concentration          unit         dr_id 
#>          6.25          5.00          1.00 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$tid
#> [1] 7
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$name
#> [1] "% CPE Inhibition @ 3.125 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$description
#> [1] "Inhibition of cytopathic effect of virus at 3.125 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[7]]$tc
#> concentration          unit         dr_id 
#>         3.125         5.000         1.000 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$tid
#> [1] 8
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$name
#> [1] "% CPE Inhibition @ 1.563 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$description
#> [1] "Inhibition of cytopathic effect of virus at 1.563 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[8]]$tc
#> concentration          unit         dr_id 
#>         1.563         5.000         1.000 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$tid
#> [1] 9
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$name
#> [1] "% CPE Inhibition @ 0.781 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.781 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[9]]$tc
#> concentration          unit         dr_id 
#>         0.781         5.000         1.000 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$tid
#> [1] 10
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$name
#> [1] "% CPE Inhibition @ 0.391 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.391 uM"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$type
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$unit
#> [1] 15
#> 
#> $PC_AssayContainer[[1]]$assay$descr$results[[10]]$tc
#> concentration          unit         dr_id 
#>         0.391         5.000         1.000 
#> 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$revision
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$activity_outcome_method
#> [1] 2
#> 
#> $PC_AssayContainer[[1]]$assay$descr$dr
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$id
#> [1] 1
#> 
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$descr
#> [1] "CR Plot Labels 1"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$dn
#> [1] "Concentration"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$dr[[1]]$rn
#> [1] "Response"
#> 
#> 
#> 
#> $PC_AssayContainer[[1]]$assay$descr$grant_number
#> [1] "1R03 MH084847-01"
#> 
#> $PC_AssayContainer[[1]]$assay$descr$project_category
#> [1] 2

For a simplified summary format that includes target information, active and inactive SID and CID counts:

result <- get_pug_rest(identifier = "1000", namespace = "aid", domain = "assay", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: summary
#>   - Identifier: 1000
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $AssaySummaries
#> $AssaySummaries$AssaySummary
#> $AssaySummaries$AssaySummary[[1]]
#> $AssaySummaries$AssaySummary[[1]]$AID
#> [1] 1000
#> 
#> $AssaySummaries$AssaySummary[[1]]$SourceName
#> [1] "SRMLSC"
#> 
#> $AssaySummaries$AssaySummary[[1]]$SourceID
#> [1] "SPE-MK-Sec"
#> 
#> $AssaySummaries$AssaySummary[[1]]$Name
#> [1] "Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK Secondary Assay"
#> 
#> $AssaySummaries$AssaySummary[[1]]$Description
#>  [1] "Southern Research Molecular Libraries Screening Center (SRMLSC) "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
#>  [2] "Southern Research Institute (Birmingham, Alabama) "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
#>  [3] "NIH Molecular Libraries Screening Centers Network (MLSCN) "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
#>  [4] "Assay Provider: Dr. Thomas S. Leyh, Albert Einstein College of medicine of Yeshiva University "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
#>  [5] "Award: R03 MH078936-01"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#>  [6] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
#>  [7] "Streptococcus pneumonia (SP) takes the lives of nearly 4,000 people daily and antibiotic resistant strains are becoming an increasing problem. Because of this, the discovery of drugs targeting novel pathways such as the mevalonate pathway has become increasingly important. The pathway produces isopentyl diphosphate (the molecular building block of isoprenoids) and is essential for the survival of the pathogen in mouse lung and serum. The mevalonate pathway is comprised of three consecutive reactions that are catalyzed by the enzymes mevalonate kinase (MK; E.C. 2.7.1.36), phosphomevalonate kinase (PMK; E.C. 2.7.4.2), and diphosphomevalonate decarboxylase (PDM-DC; E.C. 4.1.1.33). MK catalyzes the ATP dependent conversion of (R)-mevalonate to ADP plus (R)-5-phosphomevalonate. "
#>  [8] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
#>  [9] "The activity of MK was measured spectrophotometrically by coupling the formation of ADP to the reactions of pyruvate kinase and lactate dehydrogenase. The rate of ADP formation was quantitated by the reduction of absorbance (OD340) due to the oxidation of NADH to NAD by lactate dehydrogenase. A kinetic assay was chosen to minimize interference by compounds that absorbed at 340 nm."                                                                                                                                                                                                                                                                                                                                                                                                                 
#> [10] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
#> [11] "A total of 57 compounds were initially screened at a final concentration of 100 uM. Compounds with more than 20% inhibition at 100 uM were then tested in dose response assays at seven concentrations, ranging from 100 uM to 0.0156 uM depending on the % inhibition for each compound in the initial 100 uM screen. To confirm that the compounds were specifically inhibiting MK and not one of the other enzymes in the assay, the compounds were tested in parallel in an assay that contained hexokinase as the enzyme instead of MK and glucose as the substrate instead of mevalonate.  None of the compounds tested inhibited in this 'coupling enzymes' assay."                                                                                                                                       
#> 
#> $AssaySummaries$AssaySummary[[1]]$Protocol
#> [1] "Mevalonate Kinase Protocol for 1 mL cuvet assay"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
#> [2] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
#> [3] "Purified recombinant MK enzyme was provided by Dr. Thomas Leyh, Albert Einstein College of Medicine of Yeshiva University. "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#> [4] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
#> [5] "590 uL of MK reagent mix which included NADH, mevalonate, ATP, phosphoenolpyruvate, MgCl2, KCl, pyruvate kinase, and lactate dehydrogenase in buffer was added to each UV-VIS semimicro cuvet. Compounds were then added to the cuvets in 10 uL volumes in DMSO. The reaction was initiated with the addition of 400 uL of MK, diluted in assay buffer. The final concentrations in the reaction were 0.4 mM NADH, 0.2 mM melalonate, 6 mM MgCl2, 50 mM KCl, 5 mM ATP, 2 mM potassium phosphoenolpyruvate, 3 units/mL each of rabbit muscle pyruvate kinase and rabbit muscle lactate dehydrogenase, 1% DMSO, and 60 nM Mevalonate Kinase (MK) diluted in 50 mM HEPES buffer (pH 7.8) in a final volume of 1000 uL. The cuvets were immediately transferred to a CARY 3E UV-Visible Spectrophotometer and absorbance was measured at 340 nm for 3 minutes.  Each compound was tested in triplicate for the initial 100 uM screen and for the dose response assays each concentration was in triplicate.  Full reaction controls were assays with 10 uL of DMSO added instead of compound.  Background controls were assays in which 400 uL of assay buffer was added instead of MK.  "
#> [6] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
#> [7] "The 'coupling enzyme' assays were performed as above by replacing MK with hexokinase and mevalonate with glucose."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
#> 
#> $AssaySummaries$AssaySummary[[1]]$Comment
#> [1] "Percent inhibition in the single dose assay was determined by comparing the reaction rates of the compounds to that of the rate for the full reaction after subtracting the background rate using the following equation: "                                  
#> [2] ""                                                                                                                                                                                                                                                            
#> [3] "% Inhib = 100*(1-((cmpd rate-bkgrd rate)/ (full rx rate-bkgrd rate))) "                                                                                                                                                                                      
#> [4] ""                                                                                                                                                                                                                                                            
#> [5] "Dose response curves were analyzed using the four parameter logistic formula in SigmaPlot Enzyme Kinetics software."                                                                                                                                         
#> [6] " "                                                                                                                                                                                                                                                           
#> [7] "In this confirmatory dose response screen active compounds were scored on a scale of 41-80 using an inverted linear correlation to EC50s between 0 and 40 uM. Compounds that did not confirm as actives in the dose response screen were given the score 0. "
#> 
#> $AssaySummaries$AssaySummary[[1]]$NumberOfTIDs
#> [1] 27
#> 
#> $AssaySummaries$AssaySummary[[1]]$HasScore
#> [1] TRUE
#> 
#> $AssaySummaries$AssaySummary[[1]]$Method
#> [1] "confirmatory"
#> 
#> $AssaySummaries$AssaySummary[[1]]$Target
#> $AssaySummaries$AssaySummary[[1]]$Target[[1]]
#>           Accession                Name 
#>         "YP_815859" "mevalonate kinase" 
#> 
#> 
#> $AssaySummaries$AssaySummary[[1]]$Version
#> [1] 1
#> 
#> $AssaySummaries$AssaySummary[[1]]$Revision
#> [1] 2
#> 
#> $AssaySummaries$AssaySummary[[1]]$LastDataChange
#>  Year Month   Day 
#>  2008     3     5 
#> 
#> $AssaySummaries$AssaySummary[[1]]$SIDCountAll
#> [1] 57
#> 
#> $AssaySummaries$AssaySummary[[1]]$SIDCountActive
#> [1] 36
#> 
#> $AssaySummaries$AssaySummary[[1]]$SIDCountInactive
#> [1] 21
#> 
#> $AssaySummaries$AssaySummary[[1]]$SIDCountInconclusive
#> [1] 0
#> 
#> $AssaySummaries$AssaySummary[[1]]$SIDCountUnspecified
#> [1] 0
#> 
#> $AssaySummaries$AssaySummary[[1]]$SIDCountProbe
#> [1] 0
#> 
#> $AssaySummaries$AssaySummary[[1]]$CIDCountAll
#> [1] 57
#> 
#> $AssaySummaries$AssaySummary[[1]]$CIDCountActive
#> [1] 36
#> 
#> $AssaySummaries$AssaySummary[[1]]$CIDCountInactive
#> [1] 21
#> 
#> $AssaySummaries$AssaySummary[[1]]$CIDCountInconclusive
#> [1] 0
#> 
#> $AssaySummaries$AssaySummary[[1]]$CIDCountUnspecified
#> [1] 0
#> 
#> $AssaySummaries$AssaySummary[[1]]$CIDCountProbe
#> [1] 0

2. Assay Data: To retrieve the entire data set of an assay in CSV format:

result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", output = "CSV")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: <NULL>
#>   - Identifier: 504526
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>                PUBCHEM_RESULT_TAG PUBCHEM_SID PUBCHEM_CID
#> 1                     RESULT_TYPE          NA          NA
#> 2                    RESULT_DESCR          NA          NA
#> 3                     RESULT_UNIT          NA          NA
#> 4  RESULT_IS_ACTIVE_CONCENTRATION          NA          NA
#> 5       RESULT_ATTR_CONC_MICROMOL          NA          NA
#> 6                               1   103061373     6619281
#> 7                               2   103904139     2971528
#> 8                               3   109967230    50897767
#> 9                               4   109967232    50897761
#> 10                              5   109967235    50897759
#> 11                              6   104222572    22429344
#> 12                              7   104169543    49842897
#> 13                              8   104169547     6619281
#> 14                              9   104169544    49842896
#> 15                             10   104169548    49842898
#> 16                             11   103904144     4969604
#> 17                             12   109967231    50897764
#> 18                             13   109967233    50897765
#> 19                             14   109967234    50897766
#> 20                             15   109967236    50897760
#> 21                             16   109967237    50897763
#> 22                             17   109967238    50897762
#> 23                             18   109967239    50897768
#> 24                             19   104222567    49852456
#> 25                             20   104222568    49852454
#> 26                             21   104222569    22429370
#> 27                             22   104222570    15996204
#> 28                             23   104222571    49852455
#> 29                             24   104169545     1077725
#> 30                             25   104169546     5308867
#>                                              PUBCHEM_EXT_DATASOURCE_SMILES
#> 1                                                                         
#> 2                                                                         
#> 3                                                                         
#> 4                                                                         
#> 5                                                                         
#> 6                 COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 7           C1CC2=CC=CC=C2N(C1)S(=O)(=O)C3=CC=C(C=C3)NC(=O)C4CC=CCC4C(=O)O
#> 8         CC1=CC=C(C=C1)CN2C3=CC=CC=C3C(=O)N(C2=O)CC4=CC=C(C=C4)C(=O)NCCOC
#> 9         CC1=C(C=C(C=C1)Cl)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 10        CC1=C(C=C(C=C1)OC)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 11                C1CN(CCC1C(=O)NCC2=CC=CC=C2Cl)S(=O)(=O)C3=CC=CC4=NON=C43
#> 12         CC1=CC(=C(C=C1)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 13                COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 14         CC1=C(C(=CC=C1)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 15            COC1=CC=CC=C1CNC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 16           COC1=CC=CC=C1NCC(=O)NC2=C(C=CC(=C2)S(=O)(=O)N3CCOCC3)N4CCOCC4
#> 17 CC1=CC=C(C=C1)CN2C3=C(C=CC(=C3)Cl)C(=O)N(C2=O)CC4=CC=C(C=C4)C(=O)NCCCOC
#> 18     CC1=C(C=C(C=C1)C(C)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 19        CC1=CC(=C(C=C1)OC)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 20        CC1=CC(=C(C=C1)Cl)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 21  CC1=C(C=C(C=C1)C(F)(F)F)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 22  CC1=C(C=C(C=C1)C(C)(C)C)NC(=O)[C@@H]2CCCN2S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#> 23          COCCCNC(=O)C1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3N(C2=O)CC4=CC=CC=C4
#> 24                COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=C3N=CS4
#> 25                        COC1=CC=CC=C1CNC(=O)C2CCN(CC2)CC3=CC=CC4=NON=C43
#> 26              COC1=CC=CC(=C1)CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 27              COC1=CC=C(C=C1)CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 28                 CC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=NON=C43
#> 29                      COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC=C3
#> 30              COC1=CC=CC=C1CNC(=O)C2CCN(CC2)S(=O)(=O)C3=CC=CC4=C3N=CC=C4
#>    PUBCHEM_ACTIVITY_OUTCOME PUBCHEM_ACTIVITY_SCORE PUBCHEM_ACTIVITY_URL
#> 1                                               NA                   NA
#> 2                                               NA                   NA
#> 3                                               NA                   NA
#> 4                                               NA                   NA
#> 5                                               NA                   NA
#> 6                    Active                     99                   NA
#> 7                    Active                     88                   NA
#> 8                    Active                     99                   NA
#> 9                    Active                    100                   NA
#> 10                   Active                     99                   NA
#> 11                   Active                     98                   NA
#> 12                   Active                     98                   NA
#> 13                   Active                     99                   NA
#> 14                   Active                     87                   NA
#> 15                   Active                     93                   NA
#> 16                 Inactive                     81                   NA
#> 17                 Inactive                     81                   NA
#> 18                 Inactive                     81                   NA
#> 19                 Inactive                     81                   NA
#> 20                 Inactive                     81                   NA
#> 21                 Inactive                     81                   NA
#> 22                 Inactive                     81                   NA
#> 23                 Inactive                     81                   NA
#> 24                 Inactive                     81                   NA
#> 25                 Inactive                     81                   NA
#> 26                 Inactive                     81                   NA
#> 27                 Inactive                     81                   NA
#> 28                 Inactive                     81                   NA
#> 29                 Inactive                     81                   NA
#> 30                 Inactive                     81                   NA
#>    PUBCHEM_ASSAYDATA_COMMENT IC50.Modifier       IC50
#> 1                         NA        STRING      FLOAT
#> 2                         NA                         
#> 3                         NA          NONE MICROMOLAR
#> 4                         NA                     TRUE
#> 5                         NA                         
#> 6                         NA                      3.6
#> 7                         NA                     31.4
#> 8                         NA                     2.32
#> 9                         NA                     0.22
#> 10                        NA                     3.51
#> 11                        NA                      6.9
#> 12                        NA                      5.1
#> 13                        NA                      4.7
#> 14                        NA                     34.6
#> 15                        NA                     18.8
#> 16                        NA             >         50
#> 17                        NA             >         50
#> 18                        NA             >         50
#> 19                        NA             >         50
#> 20                        NA             >         50
#> 21                        NA             >         50
#> 22                        NA             >         50
#> 23                        NA             >         50
#> 24                        NA             >         50
#> 25                        NA             >         50
#> 26                        NA             >         50
#> 27                        NA             >         50
#> 28                        NA             >         50
#> 29                        NA             >         50
#> 30                        NA             >         50
#>                            X..CPE.Inhibition...50.uM
#> 1                                              FLOAT
#> 2  Inhibition of cytopathic effect of virus at 50 uM
#> 3                                            PERCENT
#> 4                                                   
#> 5                                                 50
#> 6                                              78.38
#> 7                                              47.67
#> 8                                             107.05
#> 9                                               7.51
#> 10                                             88.79
#> 11                                             78.03
#> 12                                             43.94
#> 13                                             85.88
#> 14                                             59.74
#> 15                                             72.51
#> 16                                              0.42
#> 17                                              2.59
#> 18                                             30.79
#> 19                                               9.1
#> 20                                               3.2
#> 21                                             12.15
#> 22                                              2.49
#> 23                                               2.1
#> 24                                              0.59
#> 25                                              0.58
#> 26                                              0.96
#> 27                                              1.83
#> 28                                                 2
#> 29                                              0.55
#> 30                                              0.51
#>                            X..CPE.Inhibition...25.uM
#> 1                                              FLOAT
#> 2  Inhibition of cytopathic effect of virus at 25 uM
#> 3                                            PERCENT
#> 4                                                   
#> 5                                                 25
#> 6                                               97.5
#> 7                                              68.41
#> 8                                              90.78
#> 9                                               9.47
#> 10                                             90.14
#> 11                                             86.65
#> 12                                             91.27
#> 13                                             92.21
#> 14                                             42.48
#> 15                                             61.24
#> 16                                              0.56
#> 17                                              2.63
#> 18                                             21.08
#> 19                                              11.2
#> 20                                              6.08
#> 21                                              3.83
#> 22                                              4.66
#> 23                                              2.52
#> 24                                              0.77
#> 25                                              0.54
#> 26                                              0.98
#> 27                                               1.5
#> 28                                              2.18
#> 29                                              0.69
#> 30                                              0.51
#>                             X..CPE.Inhibition...12.5.uM
#> 1                                                 FLOAT
#> 2  Inhibition of cytopathic effect of virus at 12.50 uM
#> 3                                               PERCENT
#> 4                                                      
#> 5                                                  12.5
#> 6                                                 94.84
#> 7                                                 16.83
#> 8                                                 87.53
#> 9                                                  60.4
#> 10                                                77.74
#> 11                                                83.45
#> 12                                                82.68
#> 13                                                91.99
#> 14                                                21.56
#> 15                                                40.57
#> 16                                                 0.62
#> 17                                                 2.32
#> 18                                                27.55
#> 19                                                10.88
#> 20                                                34.16
#> 21                                                 8.53
#> 22                                                 4.19
#> 23                                                 1.87
#> 24                                                 0.76
#> 25                                                 0.53
#> 26                                                 0.94
#> 27                                                 1.11
#> 28                                                 1.73
#> 29                                                 0.74
#> 30                                                 0.52
#>                            X..CPE.Inhibition...6.25.uM
#> 1                                                FLOAT
#> 2  Inhibition of cytopathic effect of virus at 6.25 uM
#> 3                                              PERCENT
#> 4                                                     
#> 5                                                 6.25
#> 6                                                95.43
#> 7                                                 2.14
#> 8                                               101.19
#> 9                                                79.75
#> 10                                               66.47
#> 11                                               47.02
#> 12                                               66.81
#> 13                                               78.58
#> 14                                                8.54
#> 15                                                  19
#> 16                                                0.43
#> 17                                                2.49
#> 18                                               17.89
#> 19                                                7.76
#> 20                                               17.15
#> 21                                                39.9
#> 22                                                3.38
#> 23                                                1.93
#> 24                                                0.94
#> 25                                                0.49
#> 26                                                0.89
#> 27                                                0.77
#> 28                                                1.56
#> 29                                                0.88
#> 30                                                0.43
#>                            X..CPE.Inhibition...3.125.uM
#> 1                                                 FLOAT
#> 2  Inhibition of cytopathic effect of virus at 3.125 uM
#> 3                                               PERCENT
#> 4                                                      
#> 5                                                 3.125
#> 6                                                 35.06
#> 7                                                  1.07
#> 8                                                 80.54
#> 9                                                 72.51
#> 10                                                48.34
#> 11                                                 12.2
#> 12                                                39.43
#> 13                                                14.87
#> 14                                                 4.49
#> 15                                                 8.08
#> 16                                                 0.51
#> 17                                                 1.96
#> 18                                                 6.44
#> 19                                                 4.61
#> 20                                                 8.56
#> 21                                                30.03
#> 22                                                 2.38
#> 23                                                 1.62
#> 24                                                 0.79
#> 25                                                  0.5
#> 26                                                 1.09
#> 27                                                 0.64
#> 28                                                 1.19
#> 29                                                 0.95
#> 30                                                 0.58
#>                            X..CPE.Inhibition...1.563.uM
#> 1                                                 FLOAT
#> 2  Inhibition of cytopathic effect of virus at 1.563 uM
#> 3                                               PERCENT
#> 4                                                      
#> 5                                                 1.563
#> 6                                                  3.21
#> 7                                                  0.93
#> 8                                                 15.81
#> 9                                                 59.35
#> 10                                                 32.2
#> 11                                                 2.23
#> 12                                                18.27
#> 13                                                 2.15
#> 14                                                 2.69
#> 15                                                 3.66
#> 16                                                 0.38
#> 17                                                  1.8
#> 18                                                 3.41
#> 19                                                 3.29
#> 20                                                 4.66
#> 21                                                14.27
#> 22                                                  1.7
#> 23                                                 1.42
#> 24                                                  0.8
#> 25                                                 0.39
#> 26                                                 0.98
#> 27                                                 0.51
#> 28                                                 0.93
#> 29                                                 0.78
#> 30                                                 0.46
#>                            X..CPE.Inhibition...0.781.uM
#> 1                                                 FLOAT
#> 2  Inhibition of cytopathic effect of virus at 0.781 uM
#> 3                                               PERCENT
#> 4                                                      
#> 5                                                 0.781
#> 6                                                  1.08
#> 7                                                  0.84
#> 8                                                  4.66
#> 9                                                 35.87
#> 10                                                15.81
#> 11                                                 0.77
#> 12                                                 6.99
#> 13                                                 0.79
#> 14                                                 1.51
#> 15                                                 1.59
#> 16                                                 0.44
#> 17                                                 1.19
#> 18                                                 2.54
#> 19                                                 2.06
#> 20                                                 3.13
#> 21                                                 5.48
#> 22                                                 1.37
#> 23                                                 1.31
#> 24                                                 0.77
#> 25                                                 0.36
#> 26                                                 0.89
#> 27                                                 0.48
#> 28                                                  0.8
#> 29                                                 0.75
#> 30                                                 0.62
#>                            X..CPE.Inhibition...0.391.uM
#> 1                                                 FLOAT
#> 2  Inhibition of cytopathic effect of virus at 0.391 uM
#> 3                                               PERCENT
#> 4                                                      
#> 5                                                 0.391
#> 6                                                   0.7
#> 7                                                  0.74
#> 8                                                  2.32
#> 9                                                 13.62
#> 10                                                 5.72
#> 11                                                 0.65
#> 12                                                 4.01
#> 13                                                 0.54
#> 14                                                 0.94
#> 15                                                 1.04
#> 16                                                 0.45
#> 17                                                 1.06
#> 18                                                 1.48
#> 19                                                 1.52
#> 20                                                 1.93
#> 21                                                 3.58
#> 22                                                 1.06
#> 23                                                 1.27
#> 24                                                 0.73
#> 25                                                 0.53
#> 26                                                 0.71
#> 27                                                 0.57
#> 28                                                 0.74
#> 29                                                  0.7
#> 30                                                 0.51

For a subset of data rows, specify the SIDs:

result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "JSON?sid=104169547,109967232", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: JSON?sid=104169547,109967232
#>   - Identifier: 504526
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
result <- pubChemData(result)
result$PC_AssaySubmit$assay
#> $descr
#> $descr$aid
#>      id version 
#>  504526       1 
#> 
#> $descr$aid_source
#> $descr$aid_source$db
#> $descr$aid_source$db$name
#> [1] "Southern Research Specialized Biocontainment Screening Center"
#> 
#> $descr$aid_source$db$source_id
#>       str 
#> "RSV_DR6" 
#> 
#> $descr$aid_source$db$date
#> $descr$aid_source$db$date$std
#>  year month   day 
#>  2012     3    18 
#> 
#> 
#> 
#> 
#> $descr$name
#> [1] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> 
#> $descr$description
#> [1] "Southern Research's Specialized Biocontainment Screening Center (SRSBSC)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
#> [2] "Southern Research Institute (Birmingham, Alabama)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
#> [3] "NIH Molecular Libraries Probe Centers Network (MLPCN)"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
#> [4] "Assay Provider: Dr. William Severson, Southern Research Institute "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
#> [5] "Grant number:  1 R03 MH082403-01A1"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
#> [6] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
#> [7] "Assay Rationale and Summary:  Currently, there are no commercially available vaccines to protect humans against Respiratory syncytial virus (RSV). RSV is associated with substantial morbidity and mortality and is the most common cause of bronchiolitis and pneumonia among infants and children under one year of age.  Nevertheless, severe lower respiratory tract disease may occur at any age, especially among the elderly or among those with compromised cardiac, pulmonary, or immune systems. The existing therapies for the acute infection are ribavirin and the prophylactic humanized monoclonal antibody (Synagis from MedImmune) that is limited to use in high risk pediatric patients.  The economic impact of RSV infections due to hospitalizations and indirect medical costs is greater than $ 650 million annually.  The assay provider has developed and validated an HTS assay that measures cytopathic effect (CPE) induced in HEp-2 cells by RSV infection, using a luminescent-based detection system for signal endpoint.  We anticipate that the proposed studies utilizing the Molecular Libraries Probes Production Network (MLPCN) HTS resources will generate multiple scaffolds targeting various junctures in the RSV viral lifecycle.  These may be furthered developed into probes to construct novel single or combination therapeutics.  "
#> 
#> $descr$protocol
#>  [1] "Cell Culture: HEp-2 cells (ATCC CCL-23, American Tissue Culture Type) were maintained as adherent cell lines in Optimem 1 with 2 mM L-glutamine and 10% fetal bovine serum (FBS) at 37oC in a humidified 5% CO2 atmosphere. Cells were passaged as needed and harvested from flasks using 0.05% trypsin-EDTA. "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#>  [2] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [3] "Assay Media - Preparation of Complete DMEM/F12: 50 mL Pen/Strep/Glutamine (Gibco, Cat. No. 10378) was added to four liters of room temperature DMEM/F12 (Sigma, Cat. No. D6434) and the pH adjusted to 7.5 using 1N NaOH. The medium was sterile filtered through a 0.2 um filter and 10 mL of HI-FBS was added per 500 mL of media."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
#>  [4] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [5] "RSV culture: Human respiratory syncytial virus (HRSV) strain Long (ATCC VR-26) was used for screening. The RSV stock was prepared in HEp-2 cells using an initial stock obtained from ATCC. Briefly, HEp-2 cells were grown in two T-175 flasks to 50% confluence in Dulbecco's Modified Eagle Medium: Nutrient Mixture F-12 (CDMEM/F12), pH 7.5 with 2.5 mM L-glutamine, 2% FBS and 125 U of penicillin, 125 ug of streptomycin per ml. 0.2 ml of RSV was added to 25 ml of CDMEM/F12. After three days incubation at 37 degrees C, 5% C02 and high humidity, the supernatant was harvested and the cell debris pelleted by centrifuging at 1,000 rpm for 5 minutes at 18 degrees C. Trehalose and FBS were added to a final concentration of 10% each and the supernatant was aliquoted (1 ml per tube) fast freeze using 100% Ethanol dry ice for five minutes and stored at -80 degrees C. These virus stocks were titrated in HEp-2 cells using an agarose overlay plaque method and the titer was 6.0E+07 pfu/ml. "
#>  [6] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [7] "Dose Response Compound Preparation: For dose response screening, compounds or carrier control (DMSO) were diluted to 6x in Complete DMEM/F12. Test compounds were serially diluted 1:2 resulting in an 8 point dose response dilution series. (final plate well concentration ranging from 50 uM to 0.39 uM and a final DMSO concentration of 0.5%). Twenty ul of each dilution was dispensed to assay plates (3% DMSO) in triplicate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
#>  [8] "Control Drug: The positive control drug for this assay, ribavirin [1] (No. 196066, MP Biomedicals, Solon, OH) was solubilized in DMSO. It was diluted and added to the assay plates as described for test compounds. Final concentration for ribavirin was 100uM. All wells contained 0.5% DMSO."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#>  [9] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#> [10] "Preparation of HEp-2 cells: Cells were harvested and resuspended to 178,000 cells per ml in Complete DMEM/F12."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#> [11] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#> [12] "Assay Set up: Sixty ul of HEp-2 cells (10,595 cells/well) forty ul of media and 20 ul of 3% DMSO were plated in the cell control wells. Sixty ul of HEp-2 cells (10,595 cells/well), forty ul of a 1:500 dilution of virus (viral MOI = 0.45) and 20 ul of compound or ribavirin control drug were added to the virus control and compound wells. All cell plating was conducted using a Matrix WellMate and cells were maintained at room temperature with stirring during the plating process. The assay plates were incubated for six days at 37 degrees C, 5% CO2 and 90% relative humidity. "                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [13] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
#> [14] "Data Analysis: Eight control wells containing cells only and four wells containing cells and virus were included on each assay plate and used to calculate Z' value for each plate and to normalize the data on a per plate basis.  Results are reported as percent (%) CPE inhibition and were calculated using the following formula: % CPE inhibition = 100*(Test Cmpd - Med Virus)/(Med Cells - Med Virus).  Four ribavirin positive control wells were included on each plate for quality control purposes. To quantify the viral cytopathic effect, IC50s were calculated for each substance using the 4 parameter Levenburg-Marquardt algorithm with the minimum and  maximum parameters locked at 0 and 100, respectively. "                                                                                                                                                                                                                                                                                     
#> 
#> $descr$comment
#> [1] "Possible artifacts in this assay include, but are not limited to, compounds that interfere with the luciferase reaction, absorb luminescence, or precipitate."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
#> [2] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [3] "Compounds that demonstrated at least 50% inhibition and were considered active. "                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [4] ""                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
#> [5] "The following tiered system has been implemented at Southern Research Institute for use with the PubChem Score. Compounds in the primary screen are scored on a scale of 0-40 based on inhibitory activity where a score of 40 corresponds to 100% inhibition. In the initial confirmatory dose response screen, active compounds were scored on a scale of 41-80 based on the IC50 result while compounds that did not confirm as actives were given the score of 0. In assays using purified and synthesized compounds a scale of 81-100 based on the IC50 result is used to denote a high level of confidence in both the substance and the data. Compounds that did not confirm activity were given the score of 0."
#> 
#> $descr$xref
#> $descr$xref[[1]]
#> $descr$xref[[1]]$xref
#>  aid 
#> 2391 
#> 
#> $descr$xref[[1]]$comment
#> [1] "Primary and confirmatory screen."
#> 
#> 
#> $descr$xref[[2]]
#> $descr$xref[[2]]$xref
#>  aid 
#> 2410 
#> 
#> $descr$xref[[2]]$comment
#> [1] "Cytotoxicity of primary screen hits."
#> 
#> 
#> $descr$xref[[3]]
#> $descr$xref[[3]]$xref
#>    aid 
#> 449732 
#> 
#> $descr$xref[[3]]$comment
#> [1] "TCID50 on selected compounds."
#> 
#> 
#> $descr$xref[[4]]
#> $descr$xref[[4]]$xref
#>    aid 
#> 488972 
#> 
#> $descr$xref[[4]]$comment
#> [1] "Confirmatory screen (2) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[5]]
#> $descr$xref[[5]]$xref
#>    aid 
#> 488976 
#> 
#> $descr$xref[[5]]$comment
#> [1] "Cytotoxicity screen (2) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[6]]
#> $descr$xref[[6]]$xref
#>  aid 
#> 2440 
#> 
#> $descr$xref[[6]]$comment
#> [1] "Summary AID."
#> 
#> 
#> $descr$xref[[7]]
#> $descr$xref[[7]]$xref
#>    aid 
#> 492966 
#> 
#> $descr$xref[[7]]$comment
#> [1] "Confirmatory screen (3) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[8]]
#> $descr$xref[[8]]$xref
#>    aid 
#> 492968 
#> 
#> $descr$xref[[8]]$comment
#> [1] "Cytotoxicity screen (3) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[9]]
#> $descr$xref[[9]]$xref
#>    aid 
#> 493016 
#> 
#> $descr$xref[[9]]$comment
#> [1] "Confirmatory screen (4) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[10]]
#> $descr$xref[[10]]$xref
#>    aid 
#> 493015 
#> 
#> $descr$xref[[10]]$comment
#> [1] "Cytotoxicity screen (4) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[11]]
#> $descr$xref[[11]]$xref
#>    aid 
#> 493088 
#> 
#> $descr$xref[[11]]$comment
#> [1] "Confirmatory screen (5) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[12]]
#> $descr$xref[[12]]$xref
#>    aid 
#> 493090 
#> 
#> $descr$xref[[12]]$comment
#> [1] "Cytotoxicity screen (5) on purified and synthesized compounds."
#> 
#> 
#> $descr$xref[[13]]
#> $descr$xref[[13]]$xref
#> taxonomy 
#>    12814 
#> 
#> 
#> 
#> $descr$results
#> $descr$results[[1]]
#> $descr$results[[1]]$tid
#> [1] 1
#> 
#> $descr$results[[1]]$name
#> [1] "IC50 Modifier"
#> 
#> $descr$results[[1]]$type
#> [1] 4
#> 
#> $descr$results[[1]]$unit
#> [1] 254
#> 
#> 
#> $descr$results[[2]]
#> $descr$results[[2]]$tid
#> [1] 2
#> 
#> $descr$results[[2]]$name
#> [1] "IC50"
#> 
#> $descr$results[[2]]$type
#> [1] 1
#> 
#> $descr$results[[2]]$unit
#> [1] 5
#> 
#> $descr$results[[2]]$ac
#> [1] TRUE
#> 
#> 
#> $descr$results[[3]]
#> $descr$results[[3]]$tid
#> [1] 3
#> 
#> $descr$results[[3]]$name
#> [1] "% CPE Inhibition @ 50 uM"
#> 
#> $descr$results[[3]]$description
#> [1] "Inhibition of cytopathic effect of virus at 50 uM"
#> 
#> $descr$results[[3]]$type
#> [1] 1
#> 
#> $descr$results[[3]]$unit
#> [1] 15
#> 
#> $descr$results[[3]]$tc
#> concentration          unit         dr_id 
#>            50             5             1 
#> 
#> 
#> $descr$results[[4]]
#> $descr$results[[4]]$tid
#> [1] 4
#> 
#> $descr$results[[4]]$name
#> [1] "% CPE Inhibition @ 25 uM"
#> 
#> $descr$results[[4]]$description
#> [1] "Inhibition of cytopathic effect of virus at 25 uM"
#> 
#> $descr$results[[4]]$type
#> [1] 1
#> 
#> $descr$results[[4]]$unit
#> [1] 15
#> 
#> $descr$results[[4]]$tc
#> concentration          unit         dr_id 
#>            25             5             1 
#> 
#> 
#> $descr$results[[5]]
#> $descr$results[[5]]$tid
#> [1] 5
#> 
#> $descr$results[[5]]$name
#> [1] "% CPE Inhibition @ 12.5 uM"
#> 
#> $descr$results[[5]]$description
#> [1] "Inhibition of cytopathic effect of virus at 12.50 uM"
#> 
#> $descr$results[[5]]$type
#> [1] 1
#> 
#> $descr$results[[5]]$unit
#> [1] 15
#> 
#> $descr$results[[5]]$tc
#> concentration          unit         dr_id 
#>          12.5           5.0           1.0 
#> 
#> 
#> $descr$results[[6]]
#> $descr$results[[6]]$tid
#> [1] 6
#> 
#> $descr$results[[6]]$name
#> [1] "% CPE Inhibition @ 6.25 uM"
#> 
#> $descr$results[[6]]$description
#> [1] "Inhibition of cytopathic effect of virus at 6.25 uM"
#> 
#> $descr$results[[6]]$type
#> [1] 1
#> 
#> $descr$results[[6]]$unit
#> [1] 15
#> 
#> $descr$results[[6]]$tc
#> concentration          unit         dr_id 
#>          6.25          5.00          1.00 
#> 
#> 
#> $descr$results[[7]]
#> $descr$results[[7]]$tid
#> [1] 7
#> 
#> $descr$results[[7]]$name
#> [1] "% CPE Inhibition @ 3.125 uM"
#> 
#> $descr$results[[7]]$description
#> [1] "Inhibition of cytopathic effect of virus at 3.125 uM"
#> 
#> $descr$results[[7]]$type
#> [1] 1
#> 
#> $descr$results[[7]]$unit
#> [1] 15
#> 
#> $descr$results[[7]]$tc
#> concentration          unit         dr_id 
#>         3.125         5.000         1.000 
#> 
#> 
#> $descr$results[[8]]
#> $descr$results[[8]]$tid
#> [1] 8
#> 
#> $descr$results[[8]]$name
#> [1] "% CPE Inhibition @ 1.563 uM"
#> 
#> $descr$results[[8]]$description
#> [1] "Inhibition of cytopathic effect of virus at 1.563 uM"
#> 
#> $descr$results[[8]]$type
#> [1] 1
#> 
#> $descr$results[[8]]$unit
#> [1] 15
#> 
#> $descr$results[[8]]$tc
#> concentration          unit         dr_id 
#>         1.563         5.000         1.000 
#> 
#> 
#> $descr$results[[9]]
#> $descr$results[[9]]$tid
#> [1] 9
#> 
#> $descr$results[[9]]$name
#> [1] "% CPE Inhibition @ 0.781 uM"
#> 
#> $descr$results[[9]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.781 uM"
#> 
#> $descr$results[[9]]$type
#> [1] 1
#> 
#> $descr$results[[9]]$unit
#> [1] 15
#> 
#> $descr$results[[9]]$tc
#> concentration          unit         dr_id 
#>         0.781         5.000         1.000 
#> 
#> 
#> $descr$results[[10]]
#> $descr$results[[10]]$tid
#> [1] 10
#> 
#> $descr$results[[10]]$name
#> [1] "% CPE Inhibition @ 0.391 uM"
#> 
#> $descr$results[[10]]$description
#> [1] "Inhibition of cytopathic effect of virus at 0.391 uM"
#> 
#> $descr$results[[10]]$type
#> [1] 1
#> 
#> $descr$results[[10]]$unit
#> [1] 15
#> 
#> $descr$results[[10]]$tc
#> concentration          unit         dr_id 
#>         0.391         5.000         1.000 
#> 
#> 
#> 
#> $descr$revision
#> [1] 1
#> 
#> $descr$activity_outcome_method
#> [1] 2
#> 
#> $descr$dr
#> $descr$dr[[1]]
#> $descr$dr[[1]]$id
#> [1] 1
#> 
#> $descr$dr[[1]]$descr
#> [1] "CR Plot Labels 1"
#> 
#> $descr$dr[[1]]$dn
#> [1] "Concentration"
#> 
#> $descr$dr[[1]]$rn
#> [1] "Response"
#> 
#> 
#> 
#> $descr$grant_number
#> [1] "1R03 MH084847-01"
#> 
#> $descr$project_category
#> [1] 2

For concise data (e.g., active concentration readout) with additional information:

result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "concise", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: concise
#>   - Identifier: 504526
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#>  [1] "AID"                 "SID"                 "CID"                
#>  [4] "Activity Outcome"    "Target Accession"    "Target GeneID"      
#>  [7] "Activity Value [uM]" "Activity Name"       "Assay Name"         
#> [10] "Assay Type"          "PubMed ID"           "RNAi"               
#> 
#> 
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "103061373"                                                                                                                         
#>  [3] "6619281"                                                                                                                           
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "3.6"                                                                                                                               
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "103904139"                                                                                                                         
#>  [3] "2971528"                                                                                                                           
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "31.4"                                                                                                                              
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "103904144"                                                                                                                         
#>  [3] "4969604"                                                                                                                           
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104169543"                                                                                                                         
#>  [3] "49842897"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "5.1"                                                                                                                               
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104169544"                                                                                                                         
#>  [3] "49842896"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "34.6"                                                                                                                              
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104169545"                                                                                                                         
#>  [3] "1077725"                                                                                                                           
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104169546"                                                                                                                         
#>  [3] "5308867"                                                                                                                           
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104169547"                                                                                                                         
#>  [3] "6619281"                                                                                                                           
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "4.7"                                                                                                                               
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104169548"                                                                                                                         
#>  [3] "49842898"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "18.8"                                                                                                                              
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104222567"                                                                                                                         
#>  [3] "49852456"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104222568"                                                                                                                         
#>  [3] "49852454"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104222569"                                                                                                                         
#>  [3] "22429370"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104222570"                                                                                                                         
#>  [3] "15996204"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104222571"                                                                                                                         
#>  [3] "49852455"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "104222572"                                                                                                                         
#>  [3] "22429344"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "6.9"                                                                                                                               
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967230"                                                                                                                         
#>  [3] "50897767"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "2.32"                                                                                                                              
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967231"                                                                                                                         
#>  [3] "50897764"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967232"                                                                                                                         
#>  [3] "50897761"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "0.22"                                                                                                                              
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[19]]
#> $Table$Row[[19]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967233"                                                                                                                         
#>  [3] "50897765"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[20]]
#> $Table$Row[[20]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967234"                                                                                                                         
#>  [3] "50897766"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[21]]
#> $Table$Row[[21]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967235"                                                                                                                         
#>  [3] "50897759"                                                                                                                          
#>  [4] "Active"                                                                                                                            
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "3.51"                                                                                                                              
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[22]]
#> $Table$Row[[22]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967236"                                                                                                                         
#>  [3] "50897760"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[23]]
#> $Table$Row[[23]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967237"                                                                                                                         
#>  [3] "50897763"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[24]]
#> $Table$Row[[24]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967238"                                                                                                                         
#>  [3] "50897762"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""                                                                                                                                  
#> 
#> 
#> $Table$Row[[25]]
#> $Table$Row[[25]]$Cell
#>  [1] "504526"                                                                                                                            
#>  [2] "109967239"                                                                                                                         
#>  [3] "50897768"                                                                                                                          
#>  [4] "Inactive"                                                                                                                          
#>  [5] ""                                                                                                                                  
#>  [6] ""                                                                                                                                  
#>  [7] "50"                                                                                                                                
#>  [8] "IC50"                                                                                                                              
#>  [9] "A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6)"
#> [10] "Confirmatory"                                                                                                                      
#> [11] ""                                                                                                                                  
#> [12] ""

For dose-response curve data:

result <- get_pug_rest(identifier = "504526", namespace = "aid", domain = "assay", operation = "doseresponse/CSV?sid=104169547,109967232", output = "CSV")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: doseresponse/CSV?sid=104169547,109967232
#>   - Identifier: 504526
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>        AID       SID Concentration Concentration.Unit Response Response.Unit
#> 1   504526 103061373        50.000                 uM    78.38             %
#> 2   504526 103061373        25.000                 uM    97.50             %
#> 3   504526 103061373        12.500                 uM    94.84             %
#> 4   504526 103061373         6.250                 uM    95.43             %
#> 5   504526 103061373         3.125                 uM    35.06             %
#> 6   504526 103061373         1.563                 uM     3.21             %
#> 7   504526 103061373         0.781                 uM     1.08             %
#> 8   504526 103061373         0.391                 uM     0.70             %
#> 9   504526 103904139        50.000                 uM    47.67             %
#> 10  504526 103904139        25.000                 uM    68.41             %
#> 11  504526 103904139        12.500                 uM    16.83             %
#> 12  504526 103904139         6.250                 uM     2.14             %
#> 13  504526 103904139         3.125                 uM     1.07             %
#> 14  504526 103904139         1.563                 uM     0.93             %
#> 15  504526 103904139         0.781                 uM     0.84             %
#> 16  504526 103904139         0.391                 uM     0.74             %
#> 17  504526 103904144        50.000                 uM     0.42             %
#> 18  504526 103904144        25.000                 uM     0.56             %
#> 19  504526 103904144        12.500                 uM     0.62             %
#> 20  504526 103904144         6.250                 uM     0.43             %
#> 21  504526 103904144         3.125                 uM     0.51             %
#> 22  504526 103904144         1.563                 uM     0.38             %
#> 23  504526 103904144         0.781                 uM     0.44             %
#> 24  504526 103904144         0.391                 uM     0.45             %
#> 25  504526 104169543        50.000                 uM    43.94             %
#> 26  504526 104169543        25.000                 uM    91.27             %
#> 27  504526 104169543        12.500                 uM    82.68             %
#> 28  504526 104169543         6.250                 uM    66.81             %
#> 29  504526 104169543         3.125                 uM    39.43             %
#> 30  504526 104169543         1.563                 uM    18.27             %
#> 31  504526 104169543         0.781                 uM     6.99             %
#> 32  504526 104169543         0.391                 uM     4.01             %
#> 33  504526 104169544        50.000                 uM    59.74             %
#> 34  504526 104169544        25.000                 uM    42.48             %
#> 35  504526 104169544        12.500                 uM    21.56             %
#> 36  504526 104169544         6.250                 uM     8.54             %
#> 37  504526 104169544         3.125                 uM     4.49             %
#> 38  504526 104169544         1.563                 uM     2.69             %
#> 39  504526 104169544         0.781                 uM     1.51             %
#> 40  504526 104169544         0.391                 uM     0.94             %
#> 41  504526 104169545        50.000                 uM     0.55             %
#> 42  504526 104169545        25.000                 uM     0.69             %
#> 43  504526 104169545        12.500                 uM     0.74             %
#> 44  504526 104169545         6.250                 uM     0.88             %
#> 45  504526 104169545         3.125                 uM     0.95             %
#> 46  504526 104169545         1.563                 uM     0.78             %
#> 47  504526 104169545         0.781                 uM     0.75             %
#> 48  504526 104169545         0.391                 uM     0.70             %
#> 49  504526 104169546        50.000                 uM     0.51             %
#> 50  504526 104169546        25.000                 uM     0.51             %
#> 51  504526 104169546        12.500                 uM     0.52             %
#> 52  504526 104169546         6.250                 uM     0.43             %
#> 53  504526 104169546         3.125                 uM     0.58             %
#> 54  504526 104169546         1.563                 uM     0.46             %
#> 55  504526 104169546         0.781                 uM     0.62             %
#> 56  504526 104169546         0.391                 uM     0.51             %
#> 57  504526 104169547        50.000                 uM    85.88             %
#> 58  504526 104169547        25.000                 uM    92.21             %
#> 59  504526 104169547        12.500                 uM    91.99             %
#> 60  504526 104169547         6.250                 uM    78.58             %
#> 61  504526 104169547         3.125                 uM    14.87             %
#> 62  504526 104169547         1.563                 uM     2.15             %
#> 63  504526 104169547         0.781                 uM     0.79             %
#> 64  504526 104169547         0.391                 uM     0.54             %
#> 65  504526 104169548        50.000                 uM    72.51             %
#> 66  504526 104169548        25.000                 uM    61.24             %
#> 67  504526 104169548        12.500                 uM    40.57             %
#> 68  504526 104169548         6.250                 uM    19.00             %
#> 69  504526 104169548         3.125                 uM     8.08             %
#> 70  504526 104169548         1.563                 uM     3.66             %
#> 71  504526 104169548         0.781                 uM     1.59             %
#> 72  504526 104169548         0.391                 uM     1.04             %
#> 73  504526 104222567        50.000                 uM     0.59             %
#> 74  504526 104222567        25.000                 uM     0.77             %
#> 75  504526 104222567        12.500                 uM     0.76             %
#> 76  504526 104222567         6.250                 uM     0.94             %
#> 77  504526 104222567         3.125                 uM     0.79             %
#> 78  504526 104222567         1.563                 uM     0.80             %
#> 79  504526 104222567         0.781                 uM     0.77             %
#> 80  504526 104222567         0.391                 uM     0.73             %
#> 81  504526 104222568        50.000                 uM     0.58             %
#> 82  504526 104222568        25.000                 uM     0.54             %
#> 83  504526 104222568        12.500                 uM     0.53             %
#> 84  504526 104222568         6.250                 uM     0.49             %
#> 85  504526 104222568         3.125                 uM     0.50             %
#> 86  504526 104222568         1.563                 uM     0.39             %
#> 87  504526 104222568         0.781                 uM     0.36             %
#> 88  504526 104222568         0.391                 uM     0.53             %
#> 89  504526 104222569        50.000                 uM     0.96             %
#> 90  504526 104222569        25.000                 uM     0.98             %
#> 91  504526 104222569        12.500                 uM     0.94             %
#> 92  504526 104222569         6.250                 uM     0.89             %
#> 93  504526 104222569         3.125                 uM     1.09             %
#> 94  504526 104222569         1.563                 uM     0.98             %
#> 95  504526 104222569         0.781                 uM     0.89             %
#> 96  504526 104222569         0.391                 uM     0.71             %
#> 97  504526 104222570        50.000                 uM     1.83             %
#> 98  504526 104222570        25.000                 uM     1.50             %
#> 99  504526 104222570        12.500                 uM     1.11             %
#> 100 504526 104222570         6.250                 uM     0.77             %
#> 101 504526 104222570         3.125                 uM     0.64             %
#> 102 504526 104222570         1.563                 uM     0.51             %
#> 103 504526 104222570         0.781                 uM     0.48             %
#> 104 504526 104222570         0.391                 uM     0.57             %
#> 105 504526 104222571        50.000                 uM     2.00             %
#> 106 504526 104222571        25.000                 uM     2.18             %
#> 107 504526 104222571        12.500                 uM     1.73             %
#> 108 504526 104222571         6.250                 uM     1.56             %
#> 109 504526 104222571         3.125                 uM     1.19             %
#> 110 504526 104222571         1.563                 uM     0.93             %
#> 111 504526 104222571         0.781                 uM     0.80             %
#> 112 504526 104222571         0.391                 uM     0.74             %
#> 113 504526 104222572        50.000                 uM    78.03             %
#> 114 504526 104222572        25.000                 uM    86.65             %
#> 115 504526 104222572        12.500                 uM    83.45             %
#> 116 504526 104222572         6.250                 uM    47.02             %
#> 117 504526 104222572         3.125                 uM    12.20             %
#> 118 504526 104222572         1.563                 uM     2.23             %
#> 119 504526 104222572         0.781                 uM     0.77             %
#> 120 504526 104222572         0.391                 uM     0.65             %
#> 121 504526 109967230        50.000                 uM   107.05             %
#> 122 504526 109967230        25.000                 uM    90.78             %
#> 123 504526 109967230        12.500                 uM    87.53             %
#> 124 504526 109967230         6.250                 uM   101.19             %
#> 125 504526 109967230         3.125                 uM    80.54             %
#> 126 504526 109967230         1.563                 uM    15.81             %
#> 127 504526 109967230         0.781                 uM     4.66             %
#> 128 504526 109967230         0.391                 uM     2.32             %
#> 129 504526 109967231        50.000                 uM     2.59             %
#> 130 504526 109967231        25.000                 uM     2.63             %
#> 131 504526 109967231        12.500                 uM     2.32             %
#> 132 504526 109967231         6.250                 uM     2.49             %
#> 133 504526 109967231         3.125                 uM     1.96             %
#> 134 504526 109967231         1.563                 uM     1.80             %
#> 135 504526 109967231         0.781                 uM     1.19             %
#> 136 504526 109967231         0.391                 uM     1.06             %
#> 137 504526 109967232        50.000                 uM     7.51             %
#> 138 504526 109967232        25.000                 uM     9.47             %
#> 139 504526 109967232        12.500                 uM    60.40             %
#> 140 504526 109967232         6.250                 uM    79.75             %
#> 141 504526 109967232         3.125                 uM    72.51             %
#> 142 504526 109967232         1.563                 uM    59.35             %
#> 143 504526 109967232         0.781                 uM    35.87             %
#> 144 504526 109967232         0.391                 uM    13.62             %
#> 145 504526 109967233        50.000                 uM    30.79             %
#> 146 504526 109967233        25.000                 uM    21.08             %
#> 147 504526 109967233        12.500                 uM    27.55             %
#> 148 504526 109967233         6.250                 uM    17.89             %
#> 149 504526 109967233         3.125                 uM     6.44             %
#> 150 504526 109967233         1.563                 uM     3.41             %
#> 151 504526 109967233         0.781                 uM     2.54             %
#> 152 504526 109967233         0.391                 uM     1.48             %
#> 153 504526 109967234        50.000                 uM     9.10             %
#> 154 504526 109967234        25.000                 uM    11.20             %
#> 155 504526 109967234        12.500                 uM    10.88             %
#> 156 504526 109967234         6.250                 uM     7.76             %
#> 157 504526 109967234         3.125                 uM     4.61             %
#> 158 504526 109967234         1.563                 uM     3.29             %
#> 159 504526 109967234         0.781                 uM     2.06             %
#> 160 504526 109967234         0.391                 uM     1.52             %
#> 161 504526 109967235        50.000                 uM    88.79             %
#> 162 504526 109967235        25.000                 uM    90.14             %
#> 163 504526 109967235        12.500                 uM    77.74             %
#> 164 504526 109967235         6.250                 uM    66.47             %
#> 165 504526 109967235         3.125                 uM    48.34             %
#> 166 504526 109967235         1.563                 uM    32.20             %
#> 167 504526 109967235         0.781                 uM    15.81             %
#> 168 504526 109967235         0.391                 uM     5.72             %
#> 169 504526 109967236        50.000                 uM     3.20             %
#> 170 504526 109967236        25.000                 uM     6.08             %
#> 171 504526 109967236        12.500                 uM    34.16             %
#> 172 504526 109967236         6.250                 uM    17.15             %
#> 173 504526 109967236         3.125                 uM     8.56             %
#> 174 504526 109967236         1.563                 uM     4.66             %
#> 175 504526 109967236         0.781                 uM     3.13             %
#> 176 504526 109967236         0.391                 uM     1.93             %
#> 177 504526 109967237        50.000                 uM    12.15             %
#> 178 504526 109967237        25.000                 uM     3.83             %
#> 179 504526 109967237        12.500                 uM     8.53             %
#> 180 504526 109967237         6.250                 uM    39.90             %
#> 181 504526 109967237         3.125                 uM    30.03             %
#> 182 504526 109967237         1.563                 uM    14.27             %
#> 183 504526 109967237         0.781                 uM     5.48             %
#> 184 504526 109967237         0.391                 uM     3.58             %
#> 185 504526 109967238        50.000                 uM     2.49             %
#> 186 504526 109967238        25.000                 uM     4.66             %
#> 187 504526 109967238        12.500                 uM     4.19             %
#> 188 504526 109967238         6.250                 uM     3.38             %
#> 189 504526 109967238         3.125                 uM     2.38             %
#> 190 504526 109967238         1.563                 uM     1.70             %
#> 191 504526 109967238         0.781                 uM     1.37             %
#> 192 504526 109967238         0.391                 uM     1.06             %
#> 193 504526 109967239        50.000                 uM     2.10             %
#> 194 504526 109967239        25.000                 uM     2.52             %
#> 195 504526 109967239        12.500                 uM     1.87             %
#> 196 504526 109967239         6.250                 uM     1.93             %
#> 197 504526 109967239         3.125                 uM     1.62             %
#> 198 504526 109967239         1.563                 uM     1.42             %
#> 199 504526 109967239         0.781                 uM     1.31             %
#> 200 504526 109967239         0.391                 uM     1.27             %

3. Targets: To retrieve assay targets, including protein or gene identifiers:

result <- get_pug_rest(identifier = c("490","1000"), namespace = "aid", domain = "assay", operation = "targets/ProteinGI,ProteinName,GeneID,GeneSymbol", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: targets/ProteinGI,ProteinName,GeneID,GeneSymbol
#>   - Identifier: 490, 1000
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $InformationList
#> $InformationList$Information
#> $InformationList$Information[[1]]
#> $InformationList$Information[[1]]$AID
#> [1] 1000
#> 
#> $InformationList$Information[[1]]$GI
#> [1] 116516899
#> 
#> $InformationList$Information[[1]]$ProteinName
#> [1] "mevalonate kinase"

To select assays via target identifier:

result <- get_pug_rest(identifier = "USP2", namespace = "target/genesymbol", domain = "assay", operation = "aids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: DomainSpecific
#>   - Operation: aids
#>   - Identifier: USP2
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>       Text
#> 1      927
#> 2     1455
#> 3     1904
#> 4     2281
#> 5   463106
#> 6   463254
#> 7   493168
#> 8   493170
#> 9   504793
#> 10  504794
#> 11  504804
#> 12  504805
#> 13  504808
#> 14  624099
#> 15  624345
#> 16  651626
#> 17  651810
#> 18  651811
#> 19  652172
#> 20  652173
#> 21  652174
#> 22  652243
#> 23  652259
#> 24  652272
#> 25  686937
#> 26  686938
#> 27  686943
#> 28  686990
#> 29  694822
#> 30  720505
#> 31  743454
#> 32  755342
#> 33  761504
#> 34 1053208
#> 35 1117281
#> 36 1117357
#> 37 1128595
#> 38 1128604
#> 39 1159506
#> 40 1159578
#> 41 1159584
#> 42 1159615
#> 43 1197975
#> 44 1224826
#> 45 1224828
#> 46 1224830
#> 47 1383944
#> 48 1383945
#> 49 1383947
#> 50 1383948
#> 51 1383950
#> 52 1383951
#> 53 1489184
#> 54 1489185
#> 55 1491550
#> 56 1508587
#> 57 1508588
#> 58 1558721
#> 59 1561164
#> 60 1649123
#> 61 1680000
#> 62 1692429
#> 63 1794863
#> 64 1802686
#> 65 1802687
#> 66 1857650
#> 67 1881105
#> 68 1897518
#> 69 1925871
#> 70 1930792
#> 71 1930821
#> 72 1930826
#> 73 1930827
#> 74 1947415
#> 75 1947418
#> 76 1947449
#> 77 1947457
#> 78 1947524

4. Activity Name: To select BioAssays by the name of the primary activity column:

result <- get_pug_rest(identifier = "EC50", namespace = "activity", domain = "assay", operation = "aids", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: DomainSpecific
#>   - Operation: aids
#>   - Identifier: EC50
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $IdentifierList
#> $IdentifierList$AID
#>     [1]     430     431     618     620     696     718     737     773     854
#>    [10]     872     874     876     936    1001    1045    1047    1050    1062
#>    [19]    1078    1192    1196    1197    1198    1200    1221    1222    1223
#>    [28]    1224    1228    1232    1234    1241    1243    1244    1245    1247
#>    [37]    1248    1252    1266    1268    1269    1270    1271    1280    1281
#>    [46]    1282    1283    1287    1289    1290    1291    1292    1293    1294
#>    [55]    1295    1299    1302    1319    1320    1322    1323    1324    1327
#>    [64]    1328    1329    1330    1331    1333    1334    1335    1336    1337
#>    [73]    1339    1340    1341    1364    1365    1366    1367    1368    1369
#>    [82]    1370    1371    1372    1373    1374    1375    1394    1397    1404
#>    [91]    1406    1412    1414    1442    1444    1450    1465    1470    1508
#>   [100]    1522    1528    1538    1562    1566    1578    1625    1659    1660
#>   [109]    1679    1681    1682    1684    1686    1689    1690    1701    1723
#>   [118]    1735    1736    1737    1738    1743    1744    1753    1757    1764
#>   [127]    1767    1769    1777    1871    1872    1884    1888    1889    1891
#>   [136]    1895    1896    1897    1900    1902    1914    1915    1923    1928
#>   [145]    1929    1930    1932    1933    1934    1935    1936    1938    1939
#>   [154]    1959    1960    1961    1964    1966    1988    1990    1994    1999
#>   [163]    2002    2003    2008    2009    2010    2019    2020    2021    2022
#>   [172]    2027    2031    2033    2036    2037    2038    2039    2040    2041
#>   [181]    2042    2043    2044    2045    2046    2047    2048    2050    2051
#>   [190]    2053    2055    2075    2077    2080    2081    2084    2086    2089
#>   [199]    2096    2102    2121    2124    2133    2137    2138    2145    2150
#>   [208]    2151    2181    2182    2183    2185    2186    2188    2190    2191
#>   [217]    2192    2193    2194    2197    2199    2207    2208    2209    2210
#>   [226]    2211    2212    2219    2220    2224    2252    2253    2284    2286
#>   [235]    2294    2295    2296    2298    2307    2310    2311    2327    2343
#>   [244]    2344    2347    2352    2359    2370    2376    2382    2387    2388
#>   [253]    2396    2398    2400    2423    2425    2428    2434    2438    2442
#>   [262]    2443    2446    2450    2452    2453    2454    2456    2457    2458
#>   [271]    2460    2463    2467    2468    2470    2471    2473    2477    2484
#>   [280]    2486    2492    2493    2497    2500    2510    2511    2518    2519
#>   [289]    2525    2548    2583    2586    2603    2607    2608    2609    2610
#>   [298]    2611    2630    2631    2633    2635    2638    2651    2654    2670
#>   [307]    2683    2696    2704    2723    2724    2725    2735    2738    2739
#>   [316]    2740    2742    2743    2744    2745    2753    2765    2807    2809
#>   [325]    2814    2821    2823    2826    2827    2828    2829    2835    2843
#>   [334]    2844    2901    2996    2997    2999    3004    3005    3006    3008
#>   [343]    3009    3015    3058    3059    3189    3385    3423    3490    3492
#>   [352]    3502    3503    3506    3507    3508    3509    3510    3513    3516
#>   [361]    3517    3519    3706    3709    3901    3902    3903    3904    3905
#>   [370]    3906    3907    3909    4494    4495    4496    4497    4498    4499
#>   [379]    4500    4501    4502    4520    4521    4550    4567    4571    4572
#>   [388]    4573    4574    4575    4576    4577    4578    4579    4580    4581
#>   [397]    4582    4666    4667    4779    4871    4872    4936    4937    4938
#>   [406]    4939    4972    4973    4974    5161    5162    5163    5165    5383
#>   [415]    5459    5460    5461    5462    5464    5465    5466    5467    5468
#>   [424]    5702    5841    5842    5843    6140    6142    6147    6148    6209
#>   [433]    6220    6224    6225    6226    6228    6229    6250    6267    6274
#>   [442]    6275    6276    6377    6380    6398    6399    8455    8619    8848
#>   [451]    8849    9404    9405    9448    9454    9465    9467    9468    9635
#>   [460]    9809    9810    9811    9812    9813   10054   19923   30287   30288
#>   [469]   30289   30291   30292   30293   30294   30295   30296   30481   30504
#>   [478]   30505   30506   30507   30508   30509   30510   30630   30631   30632
#>   [487]   30633   30634   30792   30816   30817   30818   31103   31131   31260
#>   [496]   31261   31262   31264   31265   31266   31267   31268   31269   31447
#>   [505]   31454   31829   32070   32145   32146   32147   32148   32149   32150
#>   [514]   32151   32464   32465   32785   32836   32967   32970   32972   33156
#>   [523]   33162   33163   33164   33505   33767   33768   33769   33770   33950
#>   [532]   34073   34074   34264   34265   34266   34267   34268   34269   34270
#>   [541]   34309   34436   34438   34439   34440   34584   34592   34594   34596
#>   [550]   34598   34600   34747   34748   35160   35381   35384   35390   35445
#>   [559]   35446   35447   35448   35449   35451   35452   35453   35586   35618
#>   [568]   35832   35922   35956   35957   35958   35959   35985   35987   35988
#>   [577]   35989   35990   35991   35992   35993   35994   36027   36045   36046
#>   [586]   36065   36133   36134   36135   36232   36233   36246   36261   36262
#>   [595]   36352   36385   36416   36417   36419   36420   36421   36434   36435
#>   [604]   36436   36437   36470   36512   36513   36524   36525   36526   36527
#>   [613]   36578   36579   36580   36581   36626   36627   36628   36629   36656
#>   [622]   36657   36665   36674   36675   36682   36683   36763   37036   37345
#>   [631]   37346   37347   37348   37349   37350   37497   38017   38035   38326
#>   [640]   38516   38518   38519   38533   38534   38535   38600   38694   38695
#>   [649]   38696   38742   38799   38801   38802   38803   38804   38805   39027
#>   [658]   39064   39165   39218   39867   39967   39968   40109   40110   40111
#>   [667]   40112   40114   40115   40116   40117   40118   40119   40121   40122
#>   [676]   40126   40844   40846   41017   41018   41032   41036   41037   41039
#>   [685]   41040   41041   41045   41130   41137   41159   41160   41161   41162
#>   [694]   41163   41165   41198   41199   41204   41207   41441   41442   41445
#>   [703]   41512   41513   41528   41529   41530   41531   41543   41569   41570
#>   [712]   41592   41600   41601   41634   41636   41650   41651   41652   41653
#>   [721]   41654   41655   41656   41657   41658   41660   41663   41664   41665
#>   [730]   41666   41667   41668   41669   41777   41778   41779   41780   41781
#>   [739]   41783   41785   41786   41788   41789   41790   41791   41792   41910
#>   [748]   41937   41938   41939   41940   41941   41964   42046   42047   42048
#>   [757]   42049   42050   42052   42053   42092   42107   42117   42122   42220
#>   [766]   42231   42233   42359   42382   42383   42398   42399   42593   42620
#>   [775]   42621   42622   42776   42777   42778   42831   42847   42899   43083
#>   [784]   43236   43237   43238   43239   43240   43241   43385   43386   43387
#>   [793]   43388   43389   43390   43391   43392   43393   43394   43395   43396
#>   [802]   43397   43398   43978   43979   43986   43987   43988   43990   44004
#>   [811]   44005   44006   44208   44209   44211   44212   44213   44214   44215
#>   [820]   44216   44217   44235   44340   44352   44384   44385   44393   44394
#>   [829]   44398   44399   44405   44411   44412   44541   44542   44545   44546
#>   [838]   44553   44560   44562   44563   44569   44570   44571   44591   44604
#>   [847]   44608   44610   44627   44631   44641   44642   44645   44646   44647
#>   [856]   44664   44665   44666   44667   44668   44669   44719   44735   44737
#>   [865]   44739   44740   44741   44789   44790   44791   44792   44793   44794
#>   [874]   44795   44796   44814   44816   44817   44818   44819   44820   44821
#>   [883]   44822   44823   44824   44825   44826   44827   44828   44829   44830
#>   [892]   44831   44832   44874   44998   44999   45000   45001   45002   45003
#>   [901]   45004   45025   45026   45027   45028   45029   45035   45036   45037
#>   [910]   45060   45061   45062   45063   45064   45065   45066   45067   45069
#>   [919]   45070   45071   45072   45114   45115   45290   45292   45351   45354
#>   [928]   45355   45356   45357   45358   45359   45360   45361   45362   45363
#>   [937]   45364   45365   45366   45367   45368   45369   45370   45371   45372
#>   [946]   45373   45374   45376   45378   45379   45380   45381   45382   45385
#>   [955]   45386   45387   45388   45389   45390   45391   45392   45412   45518
#>   [964]   45519   45520   45521   45522   45523   45524   45525   45526   45527
#>   [973]   45528   45529   45530   45531   45532   45533   45534   45535   45536
#>   [982]   45540   45541   45542   45543   45549   45550   45551   45552   45553
#>   [991]   45554   45555   45682   45683   45684   45685   45686   45687   45688
#>  [1000]   45689   45690   45691   45692   45693   45694   45695   45696   45697
#>  [1009]   45700   45701   45702   45704   45705   45706   45708   45709   45710
#>  [1018]   45729   45731   45736   45740   45757   45771   45772   45798   45801
#>  [1027]   45808   45809   45819   45826   45827   45828   46005   46006   46007
#>  [1036]   46008   46010   46011   46013   46014   46015   46017   46018   46019
#>  [1045]   46020   46021   46022   46023   46024   46027   46028   46033   46155
#>  [1054]   46174   46175   46176   46177   46178   46179   46180   46181   46183
#>  [1063]   46185   46186   46187   46188   46189   46190   46191   46192   46193
#>  [1072]   46196   46197   46198   46199   46200   46204   46205   46206   46208
#>  [1081]   46210   46211   46212   46240   46241   46243   46244   46246   46247
#>  [1090]   46249   46250   46251   46252   46253   46254   46255   46258   46259
#>  [1099]   46260   46261   46263   46409   46410   46412   46413   46414   46415
#>  [1108]   46416   46417   46418   46419   46420   46421   46422   46423   46424
#>  [1117]   46425   46426   46427   46428   46429   46430   46487   46618   46621
#>  [1126]   46628   46632   46637   46645   46646   46647   46648   46649   46650
#>  [1135]   46651   46652   46653   46654   46655   46656   46657   46658   46660
#>  [1144]   46661   46800   46801   46803   46804   46819   46820   46821   46822
#>  [1153]   46823   46824   46825   46827   46829   46831   46832   46833   46838
#>  [1162]   46843   46845   46846   46847   46848   46851   46954   46955   46985
#>  [1171]   46986   46987   46991   46992   46993   46996   46997   46998   46999
#>  [1180]   47001   47009   47046   47089   47090   47091   47092   47109   47111
#>  [1189]   47112   47113   47114   47115   47116   47117   47119   47122   47125
#>  [1198]   47128   47129   47130   47131   47132   47133   47136   47137   47138
#>  [1207]   47139   47140   47141   47142   47143   47147   47148   47149   47150
#>  [1216]   47188   47191   47259   47260   47261   47262   47263   47264   47265
#>  [1225]   47268   47269   47270   47272   47273   47372   47374   47375   47377
#>  [1234]   47638   47640   47651   47657   47659   47660   47661   47783   47784
#>  [1243]   47785   47787   47789   47790   49472   49474   49690   50972   50973
#>  [1252]   51033   51039   51295   51296   51935   52405   52424   52518   52521
#>  [1261]   52530   52649   52743   52881   52882   52883   53449   53467   53468
#>  [1270]   53667   53758   53759   53808   53813   53826   53827   53918   54066
#>  [1279]   54068   54123   54140   54141   54142   54435   54437   54438   54441
#>  [1288]   54862   55372   55373   55430   55438   55578   55956   55957   55958
#>  [1297]   55965   56299   56446   57053   57055   57063   57064   57548   57552
#>  [1306]   57554   57697   59110   59111   59112   59113   60966   60967   61007
#>  [1315]   61010   61012   61071   61072   61219   61220   61221   61222   61223
#>  [1324]   61225   61226   61228   61304   61491   61800   61802   61803   61858
#>  [1333]   62577   62578   62579   62580   62748   62749   62750   62751   62753
#>  [1342]   62754   62756   62757   62758   62759   62760   62761   63041   63042
#>  [1351]   63211   63212   63374   63376   63377   63378   63379   63703   63721
#>  [1360]   63828   63854   63857   63858   63859   63860   63861   63914   63915
#>  [1369]   63916   63917   63918   63939   63940   63941   63942   63943   64016
#>  [1378]   64021   64022   64321   64637   64638   64639   64640   64641   64794
#>  [1387]   64796   64798   64799   64804   64812   64813   64814   64815   64816
#>  [1396]   64817   64818   65465   65466   65467   65468   65469   65520   65769
#>  [1405]   65831   65833   65834   65922   65923   65925   65928   65965   65966
#>  [1414]   66430   66869   66958   67101   67432   67782   67813   67842   67843
#>  [1423]   67844   67963   68289   68292   68294   68660   68711   68712   68713
#>  [1432]   68714   68715   68948   68949   69103   69104   69116   69117   69119
#>  [1441]   69120   69376   69377   69854   69861   69862   70019   70020   70021
#>  [1450]   70185   70186   70187   70188   70190   70191   70209   70218   70226
#>  [1459]   70227   70504   70505   70506   70507   70551   70553   71209   71210
#>  [1468]   71211   71233   71238   71247   71264   71281   71302   71304   71405
#>  [1477]   71410   71411   71412   71413   71417   71418   71419   71532   71533
#>  [1486]   71534   71535   71536   71537   71546   71547   71694   71695   71696
#>  [1495]   71777   71797   71799   71870   71871   71872   71875   71876   71877
#>  [1504]   71879   71942   72010   72011   72012   72013   72014   72015   72016
#>  [1513]   72017   72019   72020   72157   72186   72308   72318   72325   72326
#>  [1522]   72327   72328   72329   72335   72336   72360   72409   72410   72442
#>  [1531]   72525   72526   72529   72531   72641   72642   72698   72700   72761
#>  [1540]   72782   72783   72923   72945   73026   73035   73036   73037   73038
#>  [1549]   73084   73085   73181   73189   73190   73201   73238   73239   73353
#>  [1558]   73365   73371   73519   73542   73663   73674   73686   73689   73690
#>  [1567]   73691   73702   73703   73704   73705   73706   73707   73708   73709
#>  [1576]   73711   73713   73714   73715   73717   73718   73719   73720   73721
#>  [1585]   73722   73723   73724   73725   73726   73727   73728   73729   73730
#>  [1594]   73731   73732   73733   73735   73736   73737   73738   73739   73741
#>  [1603]   73742   73773   73774   73775   73827   73868   73869   73870   73871
#>  [1612]   73872   73873   73874   73875   73876   73877   73878   73879   73880
#>  [1621]   73881   73882   73883   73884   73885   73886   73887   73888   73889
#>  [1630]   73890   73891   73892   73893   73894   73895   73896   73897   73898
#>  [1639]   73899   73900   73902   73903   73904   73907   73908   73909   74021
#>  [1648]   74022   74023   74024   74025   74026   74242   74327   74337   74355
#>  [1657]   74499   74501   74529   74644   74816   74818   74963   75015   75020
#>  [1666]   75021   75159   75331   75480   75673   75675   75758   75836   75929
#>  [1675]   75930   75931   75932   75933   75934   75935   75937   75938   75943
#>  [1684]   75945   75949   76357   78480   78482   78483   78508   78509   78607
#>  [1693]   78608   78649   78650   78652   78653   78654   78655   78656   78658
#>  [1702]   78659   78737   78759   78760   78761   78765   78770   78771   78774
#>  [1711]   78775   78776   78779   78781   78782   78783   78833   78834   78835
#>  [1720]   78836   78837   78838   78839   78840   78841   78842   78843   78844
#>  [1729]   78845   79096   79097   79098   79114   79116   79117   79276   79278
#>  [1738]   79283   79291   79293   79295   79297   79299   79301   79302   79303
#>  [1747]   79305   79446   79447   79450   79546   79547   79629   79633   79634
#>  [1756]   79637   79693   79696   79700   79701   79703   79704   79705   79706
#>  [1765]   79707   79708   79745   79746   79757   79758   79761   79818   79819
#>  [1774]   79820   79821   79822   79823   79824   79825   79882   79883   79887
#>  [1783]   79888   79890   79892   79893   79894   79895   79896   79897   79898
#>  [1792]   79899   79900   79901   79902   79903   79904   79905   79906   79916
#>  [1801]   80012   80084   80307   80308   80362   80376   80377   80378   80379
#>  [1810]   80451   80460   80575   80576   80590   80591   80886   80887   80888
#>  [1819]   80890   80891   80892   80942   80952   81084   81085   81086   81087
#>  [1828]   81088   81089   81090   81091   81092   81093   81094   81095   81096
#>  [1837]   81097   81098   81099   81100   81102   81104   81232   81235   81236
#>  [1846]   81237   81238   81239   81240   81241   81242   81243   81244   81245
#>  [1855]   81246   81247   81248   81249   81251   81252   81253   81254   81256
#>  [1864]   81257   81258   81259   81260   81261   81262   81263   81264   81265
#>  [1873]   81266   81280   81281   81364   81391   81393   81405   81407   81408
#>  [1882]   81409   81410   81411   81412   81413   81414   81415   81417   81418
#>  [1891]   81419   81551   81557   81558   81709   81737   81755   81801   81889
#>  [1900]   81890   81891   81892   81893   81920   81921   81922   81923   81924
#>  [1909]   81925   81981   81982   82110   82113   82122   82123   82124   82131
#>  [1918]   82134   82137   82195   82243   82244   82245   82246   82247   82248
#>  [1927]   82249   82250   82251   82252   82253   82254   82255   82273   82274
#>  [1936]   82282   82284   82287   82306   82307   82308   82368   82369   82370
#>  [1945]   82376   82377   82379   82380   82381   82440   82441   82442   82443
#>  [1954]   82444   82445   82446   82447   82448   82449   82450   82451   82452
#>  [1963]   82453   82454   82455   82517   82555   82556   82557   82558   82589
#>  [1972]   82590   82591   82592   82593   82594   82595   82596   82597   82598
#>  [1981]   82599   82600   82601   82602   82683   82684   82686   82688   82690
#>  [1990]   82691   82692   82693   82723   82734   82751   82828   82829   83089
#>  [1999]   83101   83108   83111   83112   83113   83114   83115   83116   83117
#>  [2008]   83118   83147   83149   83235   83249   83250   83255   83258   83264
#>  [2017]   83265   83266   83267   83268   83283   83284   83358   83359   83360
#>  [2026]   83361   83362   83363   83364   83393   83406   83408   83410   83411
#>  [2035]   83412   83413   83414   83416   83417   83418   83419   83420   83424
#>  [2044]   83425   83426   83427   83428   83547   83549   83550   83551   83552
#>  [2053]   83553   83554   83943   83944   84077   84130   84223   84224   84259
#>  [2062]   84559   84560   84561   84563   84637   84641   84661   84662   84684
#>  [2071]   84716   84717   84718   84772   84778   84793   84932   84933   84934
#>  [2080]   84935   85119   85311   85312   85430   85722   85726   85885   85886
#>  [2089]   85890   85891   85892   85893   85894   86020   86021   86022   86023
#>  [2098]   86024   86066   86068   86358   86360   86371   86372   86373   86385
#>  [2107]   86386   86387   86388   86449   86450   86451   86476   86477   86478
#>  [2116]   86563   86682   86683   86684   86717   86718   86828   86829   86831
#>  [2125]   86832   86834   86835   86836   86846   86850   86851   86853   86854
#>  [2134]   86856   86857   86863   86867   86868   86870   86872   86886   86889
#>  [2143]   86921   86922   86923   86924   86925   86926   87012   87168   87180
#>  [2152]   87182   87188   87190   87232   87375   87382   87466   87471   87479
#>  [2161]   87543   87544   87598   87599   87601   87633   87634   87664   87768
#>  [2170]   88307   88336   88346   88347   88352   88353   88354   88355   88356
#>  [2179]   88357   88358   88427   88818   88825   88980   88981   88982   88983
#>  [2188]   88986   88987   88988   88989   88990   88991   88992   88993   88994
#>  [2197]   88995   88996   88997   88999   89001   89058   89059   89060   89061
#>  [2206]   89063   89066   89157   89158   89159   89160   89161   89163   89164
#>  [2215]   89167   89168   89169   89170   89269   89271   89273   89308   89309
#>  [2224]   89454   89525   89526   89527   89540   89541   89543   89547   89549
#>  [2233]   89895   89974   90032   90033   90034   90035   90064   90065   90066
#>  [2242]   90133   90134   90135   90303   90304   90305   90307   90421   90422
#>  [2251]   90594   90678   90679   90762   90763   90805   90806   90807   90836
#>  [2260]   90838   90872   90949   90967   91046   91116   91129   91130   91138
#>  [2269]   91146   91186   91237   91241   91246   91295   91297   91299   91301
#>  [2278]   91463   91499   91500   91502   91503   91505   91506   91507   91508
#>  [2287]   91511   91525   91526   91527   91582   91583   91597   91608   91645
#>  [2296]   91646   91680   91685   91700   91722   91772   91892   91923   91924
#>  [2305]   92077   92150   92193   92194   92195   92316   92452   92453   92528
#>  [2314]   92529   92669   92670   92794   92913   92938   92948   92954   92955
#>  [2323]   92956   92957   92965   93028   93030   93033   93038   93040   93062
#>  [2332]   93073   93096   93099   93103   93104   93107   93108   93114   93127
#>  [2341]   93240   93242   93243   93244   93260   93262   93435   93974   93975
#>  [2350]   93976   93977   93978   93979   93980   93981   93982   93983   93984
#>  [2359]   93985   93989   94457   94460   94464   94513   94515   94522   94578
#>  [2368]   94579   94837   94961   95008   95009   95277   95325   95328   95329
#>  [2377]   95351   95355   95432   95435   95437   95438   95530   96003   96186
#>  [2386]   97829   97830   98016   98017   98020   98021   98022   98023   98024
#>  [2395]   99361   99500   99508   99684   99946  100082  100389  100393  100528
#>  [2404]  100529  101020  101042  101298  101657  101658  101806  101807  101808
#>  [2413]  101835  101836  101837  101999  102011  102034  102108  102328  102351
#>  [2422]  102352  102399  102400  102401  102402  102403  102434  102435  102436
#>  [2431]  102438  102510  102697  102978  102979  102982  102986  103003  103074
#>  [2440]  103077  103188  103191  103192  103195  103198  103199  103375  103502
#>  [2449]  103503  103504  103551  103552  103553  103554  103555  103604  104102
#>  [2458]  104103  104126  104127  104239  104247  104248  104270  104271  104272
#>  [2467]  104273  104274  104275  104276  104277  104278  104279  104280  104281
#>  [2476]  104282  104283  104284  104285  104286  104288  104289  104290  104291
#>  [2485]  104292  104293  104294  104295  104297  104298  104415  104426  104427
#>  [2494]  104428  104429  104430  104431  104580  104581  104597  104598  104599
#>  [2503]  104830  104835  104966  104969  104970  104972  104974  104976  104977
#>  [2512]  104980  104984  104987  104994  104997  105005  105006  105008  105009
#>  [2521]  105018  105020  105076  105077  105122  105123  105124  105127  105128
#>  [2530]  105129  105130  105131  105132  105133  105134  105135  105136  105137
#>  [2539]  105138  105139  105140  105141  105143  105144  105145  105146  105147
#>  [2548]  105148  105149  105150  105151  105152  105153  105154  105155  105156
#>  [2557]  105157  105158  105159  105160  105161  105162  105163  105164  105165
#>  [2566]  105177  105179  105180  105181  105182  105183  105184  105185  105188
#>  [2575]  105189  105190  105315  105317  105319  105320  105321  105322  105323
#>  [2584]  105324  105325  105326  105327  105328  105329  105330  105331  105332
#>  [2593]  105333  105337  105338  105339  105341  105342  105343  105344  105345
#>  [2602]  105346  105347  105348  105349  105350  105351  105352  105353  105354
#>  [2611]  105355  105356  105357  105358  105359  105360  105361  105362  105395
#>  [2620]  105397  105399  105400  105401  105402  105403  105404  105405  105406
#>  [2629]  105407  105408  105409  105411  105423  105424  105510  105511  105512
#>  [2638]  105513  105514  105515  105516  105517  105554  105555  105556  105557
#>  [2647]  105559  105561  105610  105626  105857  105905  105906  105921  105924
#>  [2656]  105928  105933  105941  105946  105986  106130  106149  106157  106171
#>  [2665]  106172  106173  106174  106175  106205  106426  106478  106555  106723
#>  [2674]  106888  106889  106890  106891  106892  106893  106894  106895  106896
#>  [2683]  106897  106898  106899  106900  106901  106902  106903  106942  106943
#>  [2692]  106944  106947  106948  106949  106950  106951  106952  106953  106954
#>  [2701]  106955  106956  106957  106958  106960  106961  106962  106964  106965
#>  [2710]  106966  106967  106968  106969  106970  106971  106972  106974  106975
#>  [2719]  106976  106977  106978  107017  107018  107019  107020  107021  107033
#>  [2728]  107034  107035  107036  107037  107041  107044  107045  107046  107047
#>  [2737]  107049  107061  107062  107063  107064  107065  107066  107068  107082
#>  [2746]  107083  107084  107085  107088  107089  107239  107240  107241  107242
#>  [2755]  107244  107245  107247  107248  107251  107252  107253  107254  107255
#>  [2764]  107260  107263  107264  107265  107267  107391  107395  107396  107403
#>  [2773]  107404  107405  107406  107408  107553  107720  107862  107863  107864
#>  [2782]  107865  107965  107966  107967  108030  108031  108032  108337  108342
#>  [2791]  108349  108352  108355  108357  108473  108474  108475  108481  108482
#>  [2800]  108483  108494  108495  108496  108497  108498  108499  108500  108501
#>  [2809]  108502  108504  108602  108603  108604  108605  108606  108607  108608
#>  [2818]  108609  108610  108611  108633  108634  108635  108636  108637  108639
#>  [2827]  108640  108645  108646  108647  108648  108649  108656  108657  108658
#>  [2836]  108659  108660  108666  108672  108674  108675  108676  108677  108678
#>  [2845]  108679  108680  108772  108776  108777  108778  108779  108780  108781
#>  [2854]  108782  108783  108784  108785  108786  108811  108838  108839  108840
#>  [2863]  108841  108842  108843  108844  108845  108937  108938  108939  108945
#>  [2872]  108957  108958  108959  108960  108961  108962  108963  108964  108965
#>  [2881]  108966  108967  108968  108969  108970  108971  108972  108973  108974
#>  [2890]  108976  108977  108978  108981  108982  108983  109003  109004  109005
#>  [2899]  109010  109011  109012  109105  109106  109107  109151  109152  109153
#>  [2908]  109168  109169  109170  109171  109172  109175  109176  109275  109276
#>  [2917]  109277  109278  109279  109281  109292  109293  109294  109295  109296
#>  [2926]  109297  109298  109299  109300  109301  109302  109303  109304  109305
#>  [2935]  109318  109320  109326  109329  109330  109331  109332  109333  109444
#>  [2944]  109445  109446  109447  109449  109453  109454  109455  109462  109464
#>  [2953]  109465  109466  109467  109468  109469  109470  109472  109477  109478
#>  [2962]  109481  109484  109485  109488  109493  109591  109593  109594  109596
#>  [2971]  109597  109599  109600  109601  109602  109603  109604  109605  109614
#>  [2980]  109615  109617  109618  109626  109893  109898  109899  109900  109901
#>  [2989]  109903  125163  125164  125201  125202  125353  125429  127496  127497
#>  [2998]  127498  127631  127633  127636  127637  127644  127646  127647  127649
#>  [3007]  127650  127651  127652  127653  127786  127788  127789  127790  127791
#>  [3016]  127792  127793  127794  127795  127796  127797  127798  127799  127800
#>  [3025]  127801  127810  138327  138328  138329  138330  138535  138538  138839
#>  [3034]  139800  139803  139930  139966  140989  140990  140992  140993  141005
#>  [3043]  141027  141033  141034  141035  141036  141037  141064  141065  141130
#>  [3052]  141234  141235  141254  141259  141300  141311  141314  141315  141319
#>  [3061]  141345  141397  141444  141445  141446  141447  141588  141597  141604
#>  [3070]  141620  141640  141866  141867  141868  141869  141903  141908  141913
#>  [3079]  141971  141990  142143  142144  142145  142270  142284  142286  142312
#>  [3088]  142313  142314  142375  142377  142378  142379  142380  142417  142440
#>  [3097]  142453  142578  142599  142612  142613  142670  142671  142679  142740
#>  [3106]  142742  142743  142785  142786  142787  142849  142855  143224  143225
#>  [3115]  143226  143354  143470  143471  143548  143552  143553  143561  143576
#>  [3124]  143659  143660  143662  143663  143666  143670  143671  143811  143969
#>  [3133]  143975  143976  143977  144104  144105  144106  144116  144123  144124
#>  [3142]  144250  144318  144319  144320  144321  144322  144323  144396  144405
#>  [3151]  144420  144550  144551  144553  144554  144555  144556  144656  144657
#>  [3160]  144823  144824  144825  144826  145201  145252  145333  145334  145355
#>  [3169]  145356  145357  145358  145359  145360  145361  145362  145495  145496
#>  [3178]  145497  145498  145499  145501  145502  145627  145657  145658  145659
#>  [3187]  145660  145804  145905  145945  145958  145959  145984  146057  146058
#>  [3196]  146059  146060  146061  146062  146063  146064  146144  146157  146158
#>  [3205]  146165  146168  146238  146289  146290  146297  146299  146305  146316
#>  [3214]  146319  146320  146321  146477  146478  146479  146646  146770  146777
#>  [3223]  146778  146779  146781  146782  146783  146784  146796  146797  146798
#>  [3232]  146799  146801  147011  147012  147407  147409  147618  147620  147621
#>  [3241]  147625  147626  147636  147659  147660  147705  147719  147721  147762
#>  [3250]  147763  147764  147771  147950  148060  148061  148062  148063  148064
#>  [3259]  148065  148066  148067  148068  148069  148070  148203  148209  148210
#>  [3268]  148326  148332  148333  148335  148336  148337  148338  148339  148340
#>  [3277]  148341  148342  148343  148345  148346  148347  148348  148429  148443
#>  [3286]  148444  148445  148501  148502  148736  148856  148857  148858  148859
#>  [3295]  148860  148861  148879  149030  149235  149238  149392  149393  149394
#>  [3304]  149613  149719  149720  149722  149723  149976  149983  149984  149986
#>  [3313]  149987  149988  149989  149990  149991  149992  149993  149994  149995
#>  [3322]  149996  149997  150144  150145  150146  150148  150151  150154  150155
#>  [3331]  150156  150157  150158  150161  150164  150165  150166  150169  150170
#>  [3340]  150171  150172  150173  150178  150184  150220  150321  150324  150330
#>  [3349]  150331  150332  150426  150463  150464  150465  150467  150468  150470
#>  [3358]  150471  150472  150473  150487  150488  150489  150490  150494  150495
#>  [3367]  150497  150498  150550  150625  150627  150633  150634  150635  150636
#>  [3376]  151294  152132  152235  152345  152346  152476  152479  152480  152481
#>  [3385]  152489  152490  152492  152493  152613  152614  152615  152616  152617
#>  [3394]  152618  152619  152620  152621  152622  152623  152624  152625  152812
#>  [3403]  152970  152972  152973  152974  152975  153098  153105  153106  153107
#>  [3412]  153108  153109  153110  153111  153112  153113  153114  153132  153135
#>  [3421]  153136  153137  153138  153139  153140  153141  153142  153143  153144
#>  [3430]  153145  153146  154147  154286  154450  154636  154637  154638  154639
#>  [3439]  154640  154769  154811  154931  154932  154933  154934  154935  154936
#>  [3448]  154937  154938  154939  154941  154954  154955  154956  154957  154958
#>  [3457]  154959  154960  154961  154962  154963  154964  154965  154966  154967
#>  [3466]  154968  154969  154970  154971  154972  154973  154974  154975  154976
#>  [3475]  155100  155101  155102  155103  155104  155105  155107  155108  155109
#>  [3484]  155110  155111  155112  155113  155114  155115  155116  155216  155793
#>  [3493]  155914  155953  155978  155979  155980  155981  155983  155984  155985
#>  [3502]  155986  155987  155988  155989  155990  155998  156123  156124  156125
#>  [3511]  156126  156127  156129  156130  156131  156132  156133  156134  156135
#>  [3520]  156137  156138  156140  156143  156145  156146  156147  156218  156231
#>  [3529]  156233  156234  156244  156359  156360  156361  156362  156374  156375
#>  [3538]  156376  156378  156379  156440  156442  156443  156451  156452  156453
#>  [3547]  156454  156455  156457  156459  156464  156466  156467  156468  156469
#>  [3556]  156512  156603  156605  156606  156607  156608  156609  156611  156612
#>  [3565]  156614  156617  156642  156784  156785  156788  156794  156795  156796
#>  [3574]  156797  156798  156799  156800  156801  156802  156931  156932  156933
#>  [3583]  156934  156935  156937  156938  156939  156941  156943  156945  156947
#>  [3592]  157054  157058  157119  157120  157121  157123  157124  157126  157127
#>  [3601]  157173  157174  157175  157176  157177  157181  157182  157183  157184
#>  [3610]  157185  157186  157187  157264  157266  157267  157278  157279  157280
#>  [3619]  157281  157283  157288  157289  157291  157293  157401  157402  157403
#>  [3628]  157404  157405  157415  157546  157547  157548  157549  157554  157567
#>  [3637]  157568  157569  157570  157571  157572  157573  157574  157575  157576
#>  [3646]  157581  157668  157671  157797  158080  158082  158107  158726  159240
#>  [3655]  159244  159270  159416  159417  159418  159419  159420  159609  159672
#>  [3664]  159673  159674  159678  159679  159681  159682  159740  159741  159868
#>  [3673]  159923  159924  159925  160040  160041  160042  160043  160044  160045
#>  [3682]  160046  160047  160049  160051  160053  160054  160055  160056  160076
#>  [3691]  160077  160090  160337  160338  160339  160340  160341  160510  160541
#>  [3700]  160542  160543  160544  160545  160549  160550  160551  160552  160553
#>  [3709]  160674  160675  160676  160690  160692  160693  160694  160695  160696
#>  [3718]  160697  160698  160779  161047  161048  161188  161189  161193  161202
#>  [3727]  161291  161292  161548  161549  161550  161551  161552  161553  161554
#>  [3736]  161555  161556  161557  161558  161559  161560  161561  161562  161563
#>  [3745]  161564  161565  161566  161587  161627  161767  161780  161781  161787
#>  [3754]  161788  161789  161790  161791  161792  161793  161794  161795  161796
#>  [3763]  161797  161798  161800  161802  161805  161809  161810  161814  161815
#>  [3772]  161816  161817  161819  161820  161888  161889  161890  161909  162392
#>  [3781]  162558  162591  162594  162595  162596  162605  162830  163322  163323
#>  [3790]  163324  163325  163326  163331  163332  163333  163817  163818  163819
#>  [3799]  163821  163822  163823  163824  163826  163827  163830  163831  163832
#>  [3808]  163833  163834  163835  163836  163964  163965  163994  164943  165066
#>  [3817]  165067  165068  165069  165070  165071  165072  165073  165074  165075
#>  [3826]  165076  165077  165078  165079  165080  165081  165082  165083  165084
#>  [3835]  165085  165086  165087  165088  165089  165090  165091  165236  165252
#>  [3844]  165253  165453  165601  165602  165606  165607  165608  165609  165610
#>  [3853]  165754  165755  165757  165904  165929  166041  166042  166043  166044
#>  [3862]  166046  166047  166048  166049  166050  166058  166203  166205  166207
#>  [3871]  166209  166211  166213  166215  166217  166222  166227  166399  166535
#>  [3880]  166696  166698  166996  166997  166998  166999  167000  167001  167002
#>  [3889]  167003  167228  167274  167277  167278  167279  167280  167281  167282
#>  [3898]  167283  167284  167285  167286  167287  167289  167290  167292  167293
#>  [3907]  167294  167295  167296  167297  167298  167299  167300  167301  167350
#>  [3916]  167435  167436  167437  167438  167439  167440  167441  167442  167443
#>  [3925]  167552  167559  167573  167582  167588  167592  167594  167597  167599
#>  [3934]  167602  167707  167708  167710  168704  168705  168742  168891  169094
#>  [3943]  169095  169096  175322  175323  175324  175325  175326  175327  175328
#>  [3952]  175329  175330  175331  175332  175333  175471  175472  175474  175475
#>  [3961]  175476  175478  175479  175480  175481  175483  175484  175487  175489
#>  [3970]  175490  175491  175492  175493  175494  175495  175496  175498  175499
#>  [3979]  175500  175504  175505  175506  175507  175511  175512  175513  175514
#>  [3988]  175656  175657  175658  175660  175661  175663  175664  175665  175666
#>  [3997]  175667  175668  175669  175670  175671  175672  175673  175674  175675
#>  [4006]  175676  175677  175678  175679  175680  175681  175684  175686  175687
#>  [4015]  175688  175689  175690  175691  175692  175693  175694  175695  175696
#>  [4024]  175697  175698  175699  175700  175701  175702  175703  175836  175837
#>  [4033]  175838  175839  175840  175841  175843  175846  175848  175849  175851
#>  [4042]  175853  175855  175856  175857  175858  175860  175868  175869  175870
#>  [4051]  175872  175873  175874  175876  175877  175878  175879  175880  175881
#>  [4060]  175882  175885  175886  175887  175888  175889  176015  176016  176017
#>  [4069]  176018  176019  176020  176021  176022  176023  176024  176027  176028
#>  [4078]  176029  176030  176031  176032  176035  176036  176038  176039  176040
#>  [4087]  176041  176042  176043  176044  176045  176046  176047  195054  195179
#>  [4096]  195180  195181  195182  195353  195354  195368  195397  195413  195414
#>  [4105]  195415  195416  195417  195419  195433  195434  195594  195736  195899
#>  [4114]  195900  195901  195921  195922  195923  195924  196215  196228  196230
#>  [4123]  196384  196559  196562  196566  196567  196568  196569  196570  196571
#>  [4132]  196572  196574  196932  196933  196934  196935  196936  196937  196938
#>  [4141]  196939  196940  196941  196943  197099  197265  197348  197349  197350
#>  [4150]  197351  197352  197353  197355  197356  197357  197358  197359  197360
#>  [4159]  197361  197362  197363  197364  197365  197366  197658  197820  197821
#>  [4168]  197822  197906  197908  197909  197919  197920  197921  197922  197923
#>  [4177]  198028  198029  198030  198031  198032  198033  198034  198035  198189
#>  [4186]  198190  198199  198201  198202  198203  198205  198207  198208  198361
#>  [4195]  198363  198364  198365  198374  198375  198376  198377  198378  198379
#>  [4204]  198381  198382  198383  198521  198522  198523  198525  198558  198559
#>  [4213]  198711  198713  198714  198715  198717  198719  198720  198883  198886
#>  [4222]  198887  198888  198889  198896  198897  198898  198899  198900  198902
#>  [4231]  198903  198904  198905  198938  199034  199036  199067  199123  199124
#>  [4240]  199198  199199  199201  199202  199204  199205  199218  199219  199220
#>  [4249]  199222  199223  199224  199320  199322  199327  199344  199346  199353
#>  [4258]  199354  199356  199358  199359  199360  199372  199373  199375  199376
#>  [4267]  199377  199378  199383  199384  199386  199388  199389  199391  199393
#>  [4276]  199475  199476  199477  199478  199479  199480  199481  199482  199483
#>  [4285]  199506  199507  199508  199618  199626  199628  199629  199631  199632
#>  [4294]  199633  199643  199644  199647  199780  199782  199783  199785  199786
#>  [4303]  199787  199788  199789  199799  199800  199801  199802  199812  199850
#>  [4312]  199851  199941  199942  199943  199945  199946  199947  199948  199957
#>  [4321]  199959  199960  199961  199973  199988  199989  199990  199991  199992
#>  [4330]  199993  199994  199995  199996  199997  199998  199999  200000  200001
#>  [4339]  200002  200003  200004  200005  200008  200009  200010  200106  200108
#>  [4348]  200109  200110  200112  200113  200115  200118  200120  200762  200784
#>  [4357]  200786  200922  200923  200924  201327  201328  201451  201453  201466
#>  [4366]  201467  201468  201470  201471  201616  201617  201783  201784  201900
#>  [4375]  201901  202341  202342  202391  202400  202484  202485  202807  202932
#>  [4384]  202933  203242  203243  203769  203770  203908  203910  203911  204031
#>  [4393]  204032  204033  204038  204039  204040  204045  204046  204047  204048
#>  [4402]  204164  204165  204175  204176  204177  204178  204262  204263  204332
#>  [4411]  205476  208096  208097  208099  208100  208226  208263  208533  208553
#>  [4420]  208555  208675  208677  208678  208679  208680  208695  208871  208872
#>  [4429]  208880  209004  209191  209321  209329  209333  209370  209371  209543
#>  [4438]  209955  209960  209973  210168  210291  210307  210453  210454  210529
#>  [4447]  210634  210635  210767  210768  211097  211098  211288  211289  211290
#>  [4456]  211291  211292  211293  211303  211304  211407  211906  211907  211908
#>  [4465]  211909  211922  211924  211925  211927  211928  212269  212381  212382
#>  [4474]  212383  212398  212399  212425  212746  212807  212808  212809  212810
#>  [4483]  212941  213162  213168  213169  213174  213178  213179  213180  213190
#>  [4492]  213192  213392  213393  213397  213450  213452  213461  213985  214056
#>  [4501]  214057  214058  214059  214060  214083  214086  214208  214574  214854
#>  [4510]  214966  215140  215143  215144  215145  215150  215151  215153  215324
#>  [4519]  215434  215435  215612  216135  216153  216154  216155  216156  216157
#>  [4528]  216278  216298  216299  216300  216301  216302  216303  216304  216305
#>  [4537]  216306  216307  216308  216378  216459  216461  216462  216463  216464
#>  [4546]  216465  216467  216468  216549  216550  216955  216956  216957  216958
#>  [4555]  216995  217192  217263  217264  217265  217266  217267  217268  217269
#>  [4564]  217293  217430  217431  217432  217433  217434  217435  217436  217493
#>  [4573]  217495  217496  217497  217507  217508  217556  217557  217558  217559
#>  [4582]  217560  217561  217562  217563  217564  217621  217659  217660  217661
#>  [4591]  217662  217664  217665  217666  217667  217668  217669  217670  217671
#>  [4600]  217672  217781  217785  217787  217806  217953  217954  218159  218161
#>  [4609]  218163  218165  218183  218184  218185  218186  218187  218296  218297
#>  [4618]  218311  218314  218469  218470  218471  218489  218490  218491  218492
#>  [4627]  218496  218497  218498  218499  218500  218502  218503  218508  218713
#>  [4636]  218766  218834  218839  218850  218854  218859  218861  218879  218881
#>  [4645]  218954  219017  219018  219066  219072  219082  219245  219246  219401
#>  [4654]  219422  219637  219638  219639  219644  219674  219760  219761  219772
#>  [4663]  219773  219775  219778  219787  219788  219828  219903  219913  219922
#>  [4672]  219936  219945  219962  220021  220029  220051  220079  220080  220391
#>  [4681]  220415  220451  220452  220734  220737  220755  220771  220773  220777
#>  [4690]  220781  220786  220787  220791  220909  220925  220926  221362  221489
#>  [4699]  221490  221501  221505  221511  221515  221517  221526  221527  221659
#>  [4708]  221663  221665  221666  221667  221670  221671  221672  221675  221676
#>  [4717]  221679  221684  221685  221686  221688  221690  221694  221695  221697
#>  [4726]  221770  221774  221828  221830  221832  221834  221835  221952  221993
#>  [4735]  222113  222114  222144  222177  222178  222292  222323  222475  222476
#>  [4744]  222477  222478  223046  223047  223049  223061  223179  223181  223182
#>  [4753]  223183  223194  223197  223200  223208  223209  223222  223355  223356
#>  [4762]  223371  223379  223390  223523  223528  223529  223541  223544  223547
#>  [4771]  223550  223555  223578  224012  224112  224183  224186  224188  224349
#>  [4780]  224558  224581  224582  224610  224611  224940  224948  224977  224978
#>  [4789]  224979  224980  225444  225716  225717  225721  225723  225724  225749
#>  [4798]  225750  225751  225752  225951  226202  227614  227628  227629  227653
#>  [4807]  227792  227795  227799  227800  227871  227872  228008  228011  228015
#>  [4816]  228016  228040  228041  228042  228178  228418  228429  228807  228808
#>  [4825]  228859  228860  228861  228862  228864  228867  228868  228869  228870
#>  [4834]  228871  228872  228873  228874  229033  229035  235906  240032  240033
#>  [4843]  240034  240035  240036  240037  240038  240039  240040  240041  240042
#>  [4852]  240044  240045  240046  240047  240048  240049  240050  240051  240052
#>  [4861]  240053  240054  240057  240058  240059  240060  240061  240062  240063
#>  [4870]  240064  240065  240067  240068  240069  240073  240074  240075  240076
#>  [4879]  240077  240078  240079  240081  240082  240083  240085  240086  240087
#>  [4888]  240088  240089  240090  240091  240092  240093  240097  240098  240099
#>  [4897]  240100  240101  240102  240103  240104  240105  240106  240108  240109
#>  [4906]  240110  240111  240112  240115  240116  240117  240119  240120  240121
#>  [4915]  240122  240123  240125  240126  240128  240129  240130  240131  240133
#>  [4924]  240134  240135  240136  240139  240140  240141  240142  240143  240144
#>  [4933]  240145  240148  240149  240150  240151  240152  240153  240155  240156
#>  [4942]  240158  240159  240160  240161  240162  240163  240165  240166  240167
#>  [4951]  240169  240170  240172  240173  240175  240176  240178  240179  240180
#>  [4960]  240181  240182  240184  240185  240186  240188  240189  240190  240192
#>  [4969]  240193  240194  240195  240196  240202  240203  240204  240205  240206
#>  [4978]  240208  240209  240210  240211  240212  240213  240214  240215  240216
#>  [4987]  240217  240218  240219  240220  240221  240222  240223  240225  240227
#>  [4996]  240228  240229  240230  240231  240232  240233  240234  240235  240236
#>  [5005]  240237  240238  240239  240240  240242  240243  240244  240245  240246
#>  [5014]  240247  240248  240249  240250  240251  240252  240253  240256  240257
#>  [5023]  240258  240265  240267  240268  240270  240271  240272  240274  240275
#>  [5032]  240276  240277  240279  240280  240281  240282  240283  240284  240291
#>  [5041]  240292  240293  240294  240295  240297  240298  240300  240301  240302
#>  [5050]  240303  240304  240307  240308  240309  240310  240311  240312  240313
#>  [5059]  240314  240315  240316  240318  240319  240321  240322  240323  240324
#>  [5068]  240325  240326  240327  240328  240329  240330  240331  240332  240333
#>  [5077]  240334  240335  240336  240337  240338  240339  240340  240341  240342
#>  [5086]  240343  240344  240345  240346  240347  240348  240349  240350  240351
#>  [5095]  240352  240353  240354  240355  240356  240357  240358  240359  240364
#>  [5104]  240365  240366  240367  240368  240372  240373  240374  240375  240376
#>  [5113]  240377  240378  240379  240380  240381  240382  240383  240384  240385
#>  [5122]  240386  240387  240388  240389  240392  243145  243146  243147  243148
#>  [5131]  243150  243454  243455  243456  246022  246023  246027  246028  246029
#>  [5140]  246030  246031  246032  246033  246034  246036  246037  246038  246039
#>  [5149]  246040  246041  246042  246043  246044  246045  246046  246047  246048
#>  [5158]  246049  246051  246052  246053  246054  246055  246056  246059  246061
#>  [5167]  246062  246063  246064  246065  246066  246067  246068  246069  246070
#>  [5176]  246071  246073  246074  246075  246076  246077  246078  246080  246081
#>  [5185]  246082  246086  246087  246088  246089  246090  246091  246092  246093
#>  [5194]  246094  246095  246096  246111  246112  246113  246115  246117  246118
#>  [5203]  246119  246120  246121  246122  246123  246124  246125  246126  246127
#>  [5212]  246128  246129  246130  246131  246132  246133  246134  246135  246136
#>  [5221]  246137  246138  246139  246140  246142  246143  246144  246145  246146
#>  [5230]  246148  246149  246150  246151  246152  246153  246154  246155  246157
#>  [5239]  246158  246159  246160  246161  246162  246163  246164  246167  246168
#>  [5248]  246169  246170  246171  246172  246173  246174  246175  246176  246177
#>  [5257]  246178  246179  246180  246181  246182  246183  246184  246185  246186
#>  [5266]  246187  246188  246189  246190  246191  246192  246193  246194  246195
#>  [5275]  246196  246197  246198  246199  246200  246201  246202  246203  246204
#>  [5284]  246205  246206  246207  246209  246210  246212  246213  246214  246215
#>  [5293]  246216  246219  246220  246221  246224  246225  246226  246227  246229
#>  [5302]  246230  246231  246232  246233  246237  246238  246240  246241  246242
#>  [5311]  246243  246244  246245  246246  246250  246251  246252  246254  246255
#>  [5320]  246256  246257  246258  246260  246261  246262  246263  246265  246266
#>  [5329]  246267  246268  246269  246272  246274  246275  246277  246278  246281
#>  [5338]  246282  246283  246287  246288  246289  246290  246291  246292  246293
#>  [5347]  246294  246295  246296  246298  246299  246300  246301  246302  246304
#>  [5356]  246305  246307  246309  246310  246311  246312  246313  246314  246315
#>  [5365]  246317  246318  246321  246322  246323  246324  246325  246326  246328
#>  [5374]  246329  246330  246331  246332  246333  246336  246337  246338  246339
#>  [5383]  246340  246341  246342  246343  246344  246345  246346  246347  246348
#>  [5392]  246349  246350  246351  246352  246354  246355  246358  246359  246360
#>  [5401]  246361  246362  246363  246364  246366  246367  246368  246369  246370
#>  [5410]  246371  246372  246373  246374  246376  246377  246378  246379  246380
#>  [5419]  246381  246382  246383  246384  246385  246386  246387  246388  246389
#>  [5428]  246390  246391  246392  246393  246394  246395  246396  246397  246399
#>  [5437]  246400  246401  246402  246403  246404  246405  246406  246407  246408
#>  [5446]  246409  246410  246411  246412  246413  246414  246415  246416  246417
#>  [5455]  246421  246422  246425  246429  246430  246431  246432  246433  246434
#>  [5464]  246435  246436  246437  246438  246439  246440  246441  246446  246447
#>  [5473]  246448  246449  246450  246451  246452  246453  246457  246458  246459
#>  [5482]  246460  246461  246462  246463  246464  246466  246467  246468  246470
#>  [5491]  246471  246472  246473  246474  246476  246477  246478  246479  246482
#>  [5500]  246483  246484  246486  246487  246488  246489  246490  246493  246499
#>  [5509]  246500  246501  246502  246503  246504  246506  246507  246508  246509
#>  [5518]  246511  246513  246514  246515  246518  246520  246521  246522  246523
#>  [5527]  246524  246525  246529  246530  246532  246536  246537  246538  246539
#>  [5536]  246540  246541  246542  246543  246544  246545  246546  246547  246548
#>  [5545]  246549  246550  246551  246552  246553  246554  246556  246557  246558
#>  [5554]  246560  246561  246562  246563  246566  246567  246568  246569  246570
#>  [5563]  246571  246572  246573  246574  246575  246579  246581  246588  246589
#>  [5572]  246590  246591  246597  246602  246614  246615  246616  246617  246626
#>  [5581]  246633  246644  246650  246651  246655  246658  246659  246660  246661
#>  [5590]  246662  246663  246664  246665  246666  246667  246668  246669  246670
#>  [5599]  246671  246672  246676  246680  246681  246682  246683  246685  246686
#>  [5608]  246687  246688  246695  246702  246704  246705  246706  246707  246711
#>  [5617]  246716  246719  246730  246733  246734  246735  246736  246737  246750
#>  [5626]  246751  246752  246753  246754  246755  246756  246757  246758  246759
#>  [5635]  246760  249502  249503  249504  249505  249506  249507  249508  249509
#>  [5644]  249511  249512  249513  249514  249515  249516  249517  249518  249519
#>  [5653]  253260  253457  253458  253459  253507  253508  253509  253510  254615
#>  [5662]  254616  254617  254618  254619  254620  254621  254622  254623  254624
#>  [5671]  254625  254626  254627  254628  254629  254630  254632  254636  254637
#>  [5680]  254638  254639  254640  254641  254642  254643  254644  254646  254647
#>  [5689]  254648  254649  254650  254651  254652  254653  254654  254655  254656
#>  [5698]  254657  254658  255195  255196  255197  255198  255635  255636  255637
#>  [5707]  255639  255640  255642  255643  255644  255646  255647  255648  255649
#>  [5716]  255650  255651  255652  255653  255654  255655  255656  255657  255662
#>  [5725]  255663  255664  255665  255666  255667  255668  255669  255670  255671
#>  [5734]  255672  256547  256548  256556  256557  256558  256759  256766  256767
#>  [5743]  256768  256769  256776  256777  256778  256863  256881  257120  257121
#>  [5752]  257135  257136  257137  257142  257166  257167  257168  257169  257179
#>  [5761]  257180  257270  257271  257272  257273  257275  257302  257304  257335
#>  [5770]  257336  257394  257395  257522  257652  257653  257800  257826  257905
#>  [5779]  258069  258070  258091  258092  258230  258231  258416  258418  258420
#>  [5788]  258422  258515  258516  258546  258632  258675  258676  258677  258678
#>  [5797]  258679  258680  258749  258750  258765  258766  258786  258787  258788
#>  [5806]  258805  258806  258807  258808  258809  258810  258953  258955  258957
#>  [5815]  258967  258970  258973  258974  258989  258990  258991  258992  258993
#>  [5824]  259169  259177  259178  259179  259181  259182  259201  259202  259203
#>  [5833]  259204  259221  259222  259335  259336  259400  259402  259410  259411
#>  [5842]  259412  259413  259414  259453  259454  259455  259527  259544  259545
#>  [5851]  259546  259547  259548  259549  259550  259551  259552  259553  259615
#>  [5860]  259623  259686  259687  259688  259689  259692  259711  259712  259713
#>  [5869]  259714  259715  259716  259754  259758  259759  259760  259793  259794
#>  [5878]  259795  259849  259977  259978  259984  260023  260024  260025  260026
#>  [5887]  260048  260058  260059  260060  260064  260065  260066  260141  260142
#>  [5896]  260154  260155  260175  260225  260235  260237  260310  260322  260323
#>  [5905]  260324  260465  260480  260481  260482  260555  260559  260715  260765
#>  [5914]  260790  260834  260992  260994  261016  261018  261019  261020  261021
#>  [5923]  261022  261023  261043  261071  261073  261075  261077  261096  261097
#>  [5932]  261212  261213  261281  261422  261424  261442  261530  261583  261586
#>  [5941]  261589  261590  261615  261677  261683  261684  261685  261686  261696
#>  [5950]  261697  261698  261699  261711  261715  261717  261838  261840  261842
#>  [5959]  261844  261855  261857  261859  261861  261864  261901  261929  261943
#>  [5968]  261944  261945  261946  261947  261948  262091  262093  262100  262101
#>  [5977]  262176  262320  262339  262352  262372  262565  262628  262629  262630
#>  [5986]  262799  262881  262953  262955  262984  263081  263152  263172  263173
#>  [5995]  263175  263185  263199  263233  263321  263338  263507  263512  263513
#>  [6004]  263514  263515  263516  263517  263518  263519  263520  263521  263522
#>  [6013]  263531  263582  263603  263604  263665  263796  263797  263799  263800
#>  [6022]  263807  263808  263855  263893  263898  263899  263920  263922  263924
#>  [6031]  264018  264019  264042  264045  264106  264108  264215  264242  264244
#>  [6040]  264336  264374  264375  264377  264437  264438  264443  264444  264515
#>  [6049]  264516  264782  264931  264932  264933  264934  264935  264939  264940
#>  [6058]  264941  265015  265017  265081  265129  265131  265133  265135  265137
#>  [6067]  265139  265141  265201  265221  265341  265342  265460  265462  265465
#>  [6076]  265467  265468  265469  265471  265472  265473  265478  265566  265573
#>  [6085]  265574  265575  265576  265583  265610  265660  265705  265706  265757
#>  [6094]  265920  265921  265922  265923  265953  266020  266069  266245  266246
#>  [6103]  266280  266281  266284  266285  266287  266365  266368  266462  266463
#>  [6112]  266464  266546  266547  266550  266551  266552  266553  266580  266581
#>  [6121]  266583  266585  266588  266655  266659  266680  266681  266719  266757
#>  [6130]  266786  266788  266949  266951  267078  267079  267081  267301  267551
#>  [6139]  267552  267645  267647  267648  267649  267650  267700  267712  267713
#>  [6148]  267714  267733  267775  267784  267813  267820  267854  267855  267856
#>  [6157]  267857  267858  267944  267945  267947  267948  267949  268029  268069
#>  [6166]  268111  268223  268224  268225  268226  268227  268254  268255  268279
#>  [6175]  268280  268284  268302  268303  268304  268305  268306  268363  268364
#>  [6184]  268365  268380  268555  268556  268557  268576  268610  268611  268613
#>  [6193]  268616  268625  268682  268683  268699  268700  268752  268753  268883
#>  [6202]  268884  268885  268991  269009  269180  269188  269190  269292  269319
#>  [6211]  269320  269321  269342  269352  269363  269369  269370  269371  269376
#>  [6220]  269459  269477  269479  269575  269577  269579  269598  269599  269685
#>  [6229]  269686  269687  269688  269689  269690  269703  269704  269793  269795
#>  [6238]  269796  269797  269798  269799  269800  269801  269802  269803  269804
#>  [6247]  269805  269870  269871  269872  269878  269884  269886  269897  269898
#>  [6256]  269899  269951  270069  270070  270071  270081  270082  270083  270084
#>  [6265]  270107  270227  270235  270236  270237  270238  270239  270240  270251
#>  [6274]  270252  270253  270304  270305  270306  270307  270358  270359  270360
#>  [6283]  270366  270367  270368  270369  270378  270379  270380  270387  270388
#>  [6292]  270389  270407  270408  270492  270575  270576  270577  270598  270600
#>  [6301]  270602  270609  270626  270628  270630  270699  270700  270701  270906
#>  [6310]  270908  270913  270919  271016  271017  271018  271019  271020  271021
#>  [6319]  271022  271052  271055  271058  271059  271060  271061  271091  271157
#>  [6328]  271158  271159  271163  271166  271167  271182  271413  271414  271415
#>  [6337]  271506  271507  271644  271663  271665  271717  271721  271722  271725
#>  [6346]  271845  272282  272284  272316  272317  272318  272319  272328  272330
#>  [6355]  272331  272394  272396  272398  272485  272570  272571  272687  272689
#>  [6364]  272716  272719  272722  272725  272734  272946  272971  272979  272982
#>  [6373]  272983  273043  273044  273046  273048  273049  273052  273053  273054
#>  [6382]  273056  273058  273059  273061  273106  273108  273206  273207  273355
#>  [6391]  273356  273357  273408  273410  273411  273414  273415  273416  273420
#>  [6400]  273421  273425  273529  273530  273532  273533  273535  273727  273903
#>  [6409]  273908  273997  273998  273999  274000  274001  274002  274003  274004
#>  [6418]  274132  274150  274175  274317  274318  274319  274320  274419  274420
#>  [6427]  274421  274437  274441  274442  274443  274444  274445  274566  274567
#>  [6436]  274568  274585  274592  274602  274676  274678  274680  274694  274696
#>  [6445]  274698  274700  274702  274798  274860  274861  274988  274995  274997
#>  [6454]  275065  275066  275067  275068  275069  275070  275071  275072  275073
#>  [6463]  275074  275075  275076  275086  275284  275367  275390  275391  275394
#>  [6472]  275395  275473  275489  275490  275491  275636  275639  275640  275742
#>  [6481]  275787  275801  276010  276055  276063  276145  276147  276149  276151
#>  [6490]  276167  276170  276171  276172  276231  276332  276405  276452  276460
#>  [6499]  276474  276475  276587  276590  276591  276646  276713  276714  276808
#>  [6508]  276975  276976  276983  276984  276985  277005  277009  277016  277148
#>  [6517]  277149  277150  277180  277181  277182  277225  277226  277350  277353
#>  [6526]  277354  277355  277356  277487  277488  277489  277490  277491  277492
#>  [6535]  277493  277494  277497  277498  277499  277500  277661  277678  277680
#>  [6544]  277842  277976  278017  278340  278344  278345  278346  278409  278410
#>  [6553]  278411  278412  278413  278414  278415  278416  278812  278813  278816
#>  [6562]  278817  278818  279482  279483  279484  279485  279486  279487  279488
#>  [6571]  279489  279490  279491  279492  279493  279494  279495  279496  279497
#>  [6580]  279498  279499  279500  279501  279502  279516  279517  279518  279519
#>  [6589]  279520  279521  279522  279523  279524  279525  279526  279527  279528
#>  [6598]  279529  279546  279547  279548  279549  279550  279551  279577  279579
#>  [6607]  279581  279710  279711  279712  279713  279714  279715  279719  279722
#>  [6616]  279723  279724  279725  279726  279727  279729  279969  279983  279988
#>  [6625]  279989  279990  279991  279992  279993  279994  279995  280013  280014
#>  [6634]  280023  280024  280025  280026  280054  280058  280060  280114  280115
#>  [6643]  280116  280297  280298  280299  280301  280390  280441  280442  280443
#>  [6652]  280492  280804  280805  280806  280836  280837  280838  280852  280853
#>  [6661]  280854  280857  280858  280859  280861  280862  280863  280864  280880
#>  [6670]  280881  280882  280883  280884  280956  280958  280960  280963  280994
#>  [6679]  281137  281139  281140  281240  281241  281243  281244  281255  281256
#>  [6688]  281261  281281  281402  281403  281407  281432  281445  281446  281447
#>  [6697]  281448  281449  281450  281465  281466  281511  281517  281520  281523
#>  [6706]  281525  281526  281698  281699  281700  281915  282082  282086  282096
#>  [6715]  282102  282103  282111  282130  282132  282134  282274  282275  282345
#>  [6724]  282350  282351  282353  282355  282356  282357  282390  282391  282392
#>  [6733]  282393  282453  282454  282455  282457  282459  282476  282564  282580
#>  [6742]  282582  282583  282584  282640  282642  282644  282645  282648  282649
#>  [6751]  282650  282651  282652  282653  282655  282657  282658  282660  282662
#>  [6760]  282705  282706  282707  282708  282719  282743  282750  282754  282791
#>  [6769]  282793  282794  282795  282903  283043  283258  283259  283260  283261
#>  [6778]  283263  283264  283265  283267  283268  283271  283272  283275  283431
#>  [6787]  283440  283442  283444  283446  283692  283813  283907  283908  283976
#>  [6796]  283977  284076  284121  284150  284158  284159  284288  284407  284408
#>  [6805]  284409  284410  284411  284448  284452  284453  284454  284455  284759
#>  [6814]  284761  284809  284810  284811  284812  284813  285943  286300  286308
#>  [6823]  286312  286541  286542  286543  286544  286546  286656  286657  286677
#>  [6832]  286711  286758  286945  286946  286947  286975  286982  287170  287171
#>  [6841]  287176  287282  287283  287581  287686  287733  287777  287791  287893
#>  [6850]  287898  288000  288001  288002  288003  288004  288007  288009  288011
#>  [6859]  288302  288422  288431  288554  288556  288558  288641  288642  288683
#>  [6868]  288685  288714  288847  288848  288855  288856  288921  288922  288925
#>  [6877]  288926  288927  288928  288948  288973  288974  288975  289106  289131
#>  [6886]  289141  289527  289606  289607  289608  289609  289610  289611  289614
#>  [6895]  289933  289934  290119  290120  290121  290122  290227  290262  290264
#>  [6904]  290286  290339  290435  290477  290478  290580  290607  290702  290703
#>  [6913]  290735  290780  290793  290799  290800  290876  290879  290901  290902
#>  [6922]  290903  290932  290935  290994  290997  290998  290999  291000  291022
#>  [6931]  291024  291027  291028  291029  291030  291033  291034  291035  291036
#>  [6940]  291037  291168  291169  291170  291171  291172  291173  291180  291241
#>  [6949]  291242  291243  291244  291280  291364  291613  291616  291762  291814
#>  [6958]  291817  291818  291861  291934  291935  291955  292083  292378  292379
#>  [6967]  292380  292381  292560  292645  292648  292699  292707  292937  292938
#>  [6976]  292939  292962  293300  293318  293371  293372  293511  293512  293555
#>  [6985]  293558  293559  293560  293561  293562  293563  293564  293565  293750
#>  [6994]  293754  293755  293756  293757  293826  293828  293830  293831  293833
#>  [7003]  293941  294053  294074  294075  294076  294090  294203  294360  294361
#>  [7012]  294362  294384  294387  294390  294393  294629  294630  294636  294637
#>  [7021]  294638  294639  294640  294817  294818  295006  295059  295060  295061
#>  [7030]  295062  295063  295064  295152  295320  295323  295324  295378  295432
#>  [7039]  295523  295635  295911  295912  295913  295914  295915  296058  296061
#>  [7048]  296076  296219  296263  296294  296301  296303  296305  296307  296522
#>  [7057]  296523  296524  296525  296541  296546  296548  296550  296552  296603
#>  [7066]  296605  296607  296642  296672  296673  296674  296675  296676  296677
#>  [7075]  296803  296804  296805  296814  296816  296887  296913  296914  296916
#>  [7084]  296918  296920  296922  296924  296940  297005  297094  297135  297137
#>  [7093]  297138  297139  297140  297141  297142  297143  297144  297149  297175
#>  [7102]  297203  297205  297217  297218  297306  297307  297308  297309  297337
#>  [7111]  297338  297345  297347  297349  297351  297353  297355  297357  297359
#>  [7120]  297362  297364  297366  297370  297371  297450  297451  297457  297459
#>  [7129]  297472  297663  297671  297837  297856  297911  297928  297929  297930
#>  [7138]  297931  297967  297968  297969  297970  297971  297990  297991  297992
#>  [7147]  297993  297994  297995  298060  298061  298062  298066  298067  298093
#>  [7156]  298201  298202  298203  298207  298211  298332  298496  298502  298545
#>  [7165]  298634  298635  298636  298764  299023  299026  299027  299028  299029
#>  [7174]  299030  299031  299090  299144  299251  299252  299281  299282  299305
#>  [7183]  299410  299412  299420  299523  299563  299564  299612  299613  299614
#>  [7192]  299621  299623  299625  299695  299750  299751  299752  299753  299754
#>  [7201]  299755  299773  299774  299787  299788  299789  299793  299922  299923
#>  [7210]  300085  300160  300163  300321  300322  300512  300514  300516  300614
#>  [7219]  300620  300622  300691  300704  300874  300877  300879  300919  300921
#>  [7228]  301152  301180  301183  301193  301247  301325  301341  301343  301356
#>  [7237]  301483  301609  301623  301624  301625  301650  301651  301821  301863
#>  [7246]  301900  301941  301953  302024  302026  302028  302101  302150  302202
#>  [7255]  302207  302249  302251  302253  302254  302255  302369  302565  302566
#>  [7264]  302620  302673  302674  302683  302769  302773  302774  302806  302808
#>  [7273]  302817  302818  302820  302984  302988  302989  303074  303095  303285
#>  [7282]  303286  303287  303288  303289  303290  303291  303357  303359  303407
#>  [7291]  303409  303411  303699  303727  303728  303734  303745  303830  303831
#>  [7300]  303954  304079  304084  304208  304334  304335  304336  304381  304398
#>  [7309]  304868  304869  304870  304871  304882  304883  304884  304885  304927
#>  [7318]  304928  304929  304930  304931  304980  305001  305012  305057  305137
#>  [7327]  305154  305220  305221  305222  305223  305235  305248  305249  305250
#>  [7336]  305251  305271  305283  305284  305285  305319  305320  305543  305544
#>  [7345]  305545  305652  305653  305654  305794  305981  305983  306141  306149
#>  [7354]  306150  306151  306152  306153  306154  306169  306171  306286  306427
#>  [7363]  306521  306525  306548  306630  306637  306713  306735  306866  307017
#>  [7372]  307018  307118  307130  307132  307134  307199  307302  307303  307304
#>  [7381]  307307  307519  307520  307667  307669  307671  307697  307699  307701
#>  [7390]  307857  307858  307878  308075  308143  308146  308148  308194  308197
#>  [7399]  308283  308287  308295  308319  308320  308321  308331  308332  308333
#>  [7408]  308431  308432  308433  308437  308438  308439  308457  308458  308459
#>  [7417]  308466  308467  308545  308653  308657  308735  308788  308789  308791
#>  [7426]  308827  308927  308986  308999  309009  309056  309094  309101  309177
#>  [7435]  309193  309208  309209  309210  309232  309257  309260  309338  309358
#>  [7444]  309359  309360  309377  309378  309413  309416  309549  309550  309637
#>  [7453]  309638  309640  309641  309675  309710  309951  309992  309993  309994
#>  [7462]  309995  309997  310009  310025  310110  310111  310150  310237  310239
#>  [7471]  310241  310252  310271  310272  310291  310293  310349  310355  310356
#>  [7480]  310357  310358  310363  310364  310365  310590  310653  310654  310686
#>  [7489]  310687  310882  310942  311523  311578  311946  311960  311961  311962
#>  [7498]  311963  311976  311985  312010  312285  312287  312472  312473  312474
#>  [7507]  312479  312492  312493  312494  312519  312551  312629  312639  312642
#>  [7516]  312783  312898  312902  312903  312904  312905  312906  312907  312910
#>  [7525]  312971  312972  312973  313034  313150  313165  313166  313191  313192
#>  [7534]  313193  313194  313261  313344  313345  313346  313450  313452  313454
#>  [7543]  313456  313458  313460  313462  313467  313747  313748  313749  313751
#>  [7552]  313753  313755  313871  313874  313876  313901  314130  314131  314172
#>  [7561]  314173  314189  314190  314212  314277  314488  314499  314502  314546
#>  [7570]  314548  314552  314710  314722  314834  314836  314933  314936  314938
#>  [7579]  315040  315041  315042  315476  315591  315736  315755  315756  315757
#>  [7588]  315822  315869  316053  316093  316116  316333  316334  316426  316500
#>  [7597]  316708  316709  316761  316762  316813  316843  316844  316845  316860
#>  [7606]  316861  316900  316901  316902  316903  316904  316905  316906  316907
#>  [7615]  316908  316909  316943  316954  317002  317010  317143  317145  317212
#>  [7624]  317213  317214  317217  317259  317288  317317  317369  317438  317532
#>  [7633]  317535  317536  317537  317538  317539  317540  317541  317542  317595
#>  [7642]  317596  317609  317636  317698  317729  317730  317731  317749  317755
#>  [7651]  317949  317952  318036  318037  318039  318121  318122  318123  318131
#>  [7660]  318220  318247  318248  318249  318265  318266  318336  318383  318404
#>  [7669]  318405  318408  318409  318410  318815  319020  319064  319175  319177
#>  [7678]  319179  319181  319183  319185  319187  319188  319189  319191  319298
#>  [7687]  319299  319562  319588  319618  319630  319743  319871  319880  319881
#>  [7696]  319882  319883  319893  319897  319898  319899  319900  319901  319902
#>  [7705]  319915  319925  319957  320050  320094  320317  320318  320319  320325
#>  [7714]  320353  320360  320361  320371  320374  320379  320417  320419  320420
#>  [7723]  320589  320637  320655  320656  320660  320686  320687  320688  320694
#>  [7732]  320695  320750  320752  320754  320802  320925  320926  320927  320928
#>  [7741]  321250  321280  321284  321339  321362  321363  321387  321388  321395
#>  [7750]  321576  321579  321653  321661  321662  321685  321686  321687  321688
#>  [7759]  321689  321690  321691  321692  321738  321740  321741  321742  321762
#>  [7768]  321763  321764  321765  321766  321767  321769  321770  321771  321787
#>  [7777]  321864  321879  321901  321903  321905  322034  322073  322074  322075
#>  [7786]  322076  322077  322087  322094  322096  322097  322098  322101  322102
#>  [7795]  322103  322104  322105  322106  322107  322108  322109  322110  322111
#>  [7804]  322112  322113  322114  322115  322116  322117  322118  322119  322120
#>  [7813]  322121  322122  322123  322223  322225  322284  322392  322454  322485
#>  [7822]  322486  322487  322756  322763  322764  322765  322770  322771  322772
#>  [7831]  322796  322825  322827  322828  322829  322830  322834  322835  322836
#>  [7840]  322837  322838  322839  322840  322841  322842  322843  322947  323176
#>  [7849]  323177  323178  323179  323397  323646  323647  323648  323649  323650
#>  [7858]  323651  323652  323653  323654  323655  323657  323658  323699  323712
#>  [7867]  323713  323743  323747  323749  323777  323922  323982  323987  324623
#>  [7876]  324624  324625  324730  324731  324732  324733  324736  324737  324738
#>  [7885]  324739  324740  324755  324756  324757  324758  324764  324765  324766
#>  [7894]  324825  324912  324913  324914  324923  324925  324971  325342  325344
#>  [7903]  325616  325617  325753  325787  325788  325805  325806  325807  325822
#>  [7912]  325843  325970  325971  325972  326134  326135  326136  326137  326159
#>  [7921]  326160  326174  326202  326205  326206  326207  326208  326210  326247
#>  [7930]  326337  326338  326340  326373  326376  326389  326395  326579  326588
#>  [7939]  326592  326595  326609  326610  327075  327201  327202  327204  327338
#>  [7948]  327339  327340  327341  327343  327344  327345  327347  327348  327349
#>  [7957]  327362  327363  327364  327365  327366  327367  327368  327369  327370
#>  [7966]  327371  327372  327373  327374  327563  327738  327872  327873  327877
#>  [7975]  328019  328020  328021  328055  328056  328057  328116  328156  328157
#>  [7984]  328158  328159  328331  328670  328850  328923  328924  328925  328926
#>  [7993]  328927  328928  328999  329099  329363  329403  329463  329464  329496
#>  [8002]  329497  329499  329522  329537  329587  329645  329646  329787  329904
#>  [8011]  329906  330479  330485  330486  330489  330491  330492  330502  330511
#>  [8020]  330551  330564  330637  330729  330732  330816  330858  330896  331027
#>  [8029]  331033  331040  331041  331042  331201  331205  331223  331343  331456
#>  [8038]  331457  331502  331517  331576  331622  331623  331625  331627  331629
#>  [8047]  331660  331682  331699  331713  331872  331874  331890  331891  331892
#>  [8056]  331905  331906  332035  332081  332929  333023  333082  333119  333120
#>  [8065]  333121  333123  333369  333370  333371  333372  333508  333509  333703
#>  [8074]  333717  333718  334201  334275  334276  334277  334278  334279  334769
#>  [8083]  335489  335492  335899  336461  337172  339060  339308  339309  339404
#>  [8092]  339406  339408  339410  339412  339414  339416  339460  339461  339656
#>  [8101]  339695  339774  339809  339819  339843  339880  339882  339883  339885
#>  [8110]  339890  339894  339898  339900  339930  339931  339932  339933  340062
#>  [8119]  340063  340076  340124  340205  340528  340608  340609  341162  341163
#>  [8128]  341179  341180  341181  341182  341183  341210  341212  341427  341510
#>  [8137]  341690  341737  341744  341745  341760  341960  341962  342104  342111
#>  [8146]  342112  342113  342114  342115  342116  342118  342119  342120  342121
#>  [8155]  342527  342531  342532  342548  342550  342552  342719  342836  342837
#>  [8164]  342838  342865  342868  342891  342892  342893  342894  342895  342908
#>  [8173]  343012  343053  343098  343118  343141  343211  343216  343399  343400
#>  [8182]  343401  343499  343514  343516  343534  343588  343613  343657  343659
#>  [8191]  343694  343714  343852  343853  343854  343889  343890  343999  344000
#>  [8200]  344044  344045  344046  344076  344105  344106  344107  344155  344246
#>  [8209]  344247  344248  344295  344299  344301  344303  344308  344312  344313
#>  [8218]  344318  344319  344475  344476  344557  344610  344658  344659  344660
#>  [8227]  344675  344687  344725  344727  344729  344731  344733  344789  344819
#>  [8236]  344821  344858  344900  344929  344930  344945  344946  345023  345025
#>  [8245]  345031  345033  345035  345037  345039  345045  345125  345184  345194
#>  [8254]  345321  345346  345361  345362  345363  345365  345366  345367  345368
#>  [8263]  345369  345370  345371  345372  345373  345374  345375  345376  345377
#>  [8272]  345378  345473  345475  345490  345492  345494  345496  345683  345832
#>  [8281]  345881  345883  345885  346253  346265  346269  346272  346671  346673
#>  [8290]  346674  346675  346837  346953  346954  346955  347098  347314  347386
#>  [8299]  347387  347506  347603  347604  347607  347608  347609  347610  347611
#>  [8308]  347612  347613  347614  347615  347616  347617  347618  347619  347620
#>  [8317]  347621  347643  347645  347646  347649  347678  347715  347766  347768
#>  [8326]  347771  347796  347799  347983  348078  348129  348320  348325  348376
#>  [8335]  348436  348437  348493  348510  348511  348700  348822  348824  348839
#>  [8344]  348844  348845  349040  349044  349079  349080  349081  349085  349086
#>  [8353]  349165  349166  349181  349210  349246  349247  349248  349270  349274
#>  [8362]  349276  349498  349695  349697  349760  349761  349762  349783  349785
#>  [8371]  349786  349841  349842  349843  349848  349857  349858  349859  349860
#>  [8380]  349861  349864  349870  350002  350155  350159  350197  350199  350201
#>  [8389]  350203  350205  350209  350212  350213  350319  350320  350544  350551
#>  [8398]  350552  350553  350583  350584  350591  350659  350668  350672  350677
#>  [8407]  350678  350679  350683  350686  350688  350690  350692  350694  350696
#>  [8416]  350698  350867  350869  350871  351090  351091  351092  351096  351360
#>  [8425]  351362  351363  351365  351444  351445  351446  351562  351563  351564
#>  [8434]  351688  351689  351760  351761  351815  351942  351943  351946  351957
#>  [8443]  351958  352015  352017  352019  352178  352180  352258  352262  352470
#>  [8452]  352472  352529  352537  352540  352647  352649  352765  352766  352768
#>  [8461]  352919  353096  353225  353226  353227  353307  353326  353348  353349
#>  [8470]  353524  353650  353686  353688  353781  353782  353783  353800  353804
#>  [8479]  353962  353965  354023  354030  354031  354042  354043  354052  354071
#>  [8488]  354072  354248  354249  354250  354541  354595  354597  354599  354600
#>  [8497]  354817  355022  355165  355253  355997  356007  356649  356744  356952
#>  [8506]  357033  357051  357295  357421  357422  357425  357436  357437  357438
#>  [8515]  357670  357671  357672  357673  357689  357690  357691  357767  357780
#>  [8524]  357781  357782  357783  357784  357785  357786  357787  357788  357789
#>  [8533]  358594  358629  358670  358735  358923  358948  359002  359003  359004
#>  [8542]  359005  359006  359007  359008  359009  359010  359011  359012  359013
#>  [8551]  359014  359015  359016  359017  359018  359019  359020  359021  359022
#>  [8560]  359228  359229  359781  359782  359783  359784  359785  359832  359833
#>  [8569]  359880  359881  359882  360418  360468  360470  360487  360488  360489
#>  [8578]  360490  360491  360492  360493  360739  360740  360741  360742  360743
#>  [8587]  360744  360745  360746  360747  360748  360749  360750  360751  360752
#>  [8596]  360753  360754  360765  361272  361585  361625  361815  361817  361854
#>  [8605]  361857  361858  361874  361876  361879  361881  361883  361951  361954
#>  [8614]  362055  362056  362057  362179  362183  362185  362446  362447  362450
#>  [8623]  362451  362454  362455  362583  362584  362585  362894  362928  363059
#>  [8632]  363236  363782  363783  363874  363916  363918  363920  363922  363997
#>  [8641]  364054  364145  364147  364157  364413  364458  364459  364587  364590
#>  [8650]  364815  364843  364844  364845  364938  365081  365154  365161  365162
#>  [8659]  365167  365168  365180  365387  365389  365392  365408  365411  365528
#>  [8668]  365529  365599  365600  365601  365653  365993  365996  366001  366003
#>  [8677]  366017  366018  366019  366020  366021  366022  366023  366024  366055
#>  [8686]  366056  366057  366058  366059  366064  366065  366066  366267  366268
#>  [8695]  366269  366270  366376  366377  366378  366379  366380  366381  366382
#>  [8704]  366383  366403  366404  366406  366517  366520  366522  366524  366548
#>  [8713]  366549  366550  366551  366552  366553  366556  366557  366558  366559
#>  [8722]  366630  366631  366663  366726  366855  366856  366857  366860  366864
#>  [8731]  366868  366903  366991  367047  367235  367236  367301  367302  367378
#>  [8740]  367681  367682  367825  367826  367838  367839  367840  367864  367865
#>  [8749]  367942  367955  368023  368094  368171  368191  368192  368558  368559
#>  [8758]  368560  368561  368592  368957  368958  368959  368960  368961  368962
#>  [8767]  368966  368967  368968  368969  368970  368971  368972  368975  368976
#>  [8776]  368978  369068  369078  369086  369094  369128  369129  369130  369131
#>  [8785]  369132  369148  369149  369461  369462  369463  369464  369837  369838
#>  [8794]  369941  369942  369943  369947  369948  369951  369952  369953  369954
#>  [8803]  369958  369960  370589  370731  370760  370984  370985  370986  370987
#>  [8812]  371092  371221  371222  371249  371250  371268  371313  371314  371350
#>  [8821]  371421  371422  371423  371498  371499  371500  371501  371502  371527
#>  [8830]  371528  371530  371568  371570  371571  371573  371576  371599  371651
#>  [8839]  371673  371677  371678  371699  371700  371701  371734  371736  371738
#>  [8848]  371740  371742  371896  371898  371899  371900  371901  371902  371903
#>  [8857]  371904  371905  371906  371907  371908  371909  371910  371911  371912
#>  [8866]  371914  371996  371998  372015  372044  372054  372055  372056  372372
#>  [8875]  372373  372374  372375  372644  372961  372962  372963  372964  372965
#>  [8884]  372966  372967  372968  373065  373066  373067  373107  373441  373442
#>  [8893]  373443  373541  373576  373577  373578  373686  373704  373705  373707
#>  [8902]  373708  373737  373738  373739  373740  373741  373742  374087  374090
#>  [8911]  374091  374193  374194  374198  374199  374234  374349  374351  374356
#>  [8920]  374592  374600  374756  374757  374758  374759  374760  375199  375200
#>  [8929]  375201  375202  375203  375208  375209  375210  375211  375212  375213
#>  [8938]  375214  375382  375383  375384  375385  375395  375399  375408  375423
#>  [8947]  375443  375444  375453  375454  375474  375476  375478  375492  375513
#>  [8956]  375519  375520  375521  375522  375523  375524  375525  375534  375547
#>  [8965]  375548  375549  375550  375572  375582  375583  375584  375585  375612
#>  [8974]  375618  375807  375808  375832  375833  375834  375843  375861  375863
#>  [8983]  375870  375871  375872  376629  376637  377072  377073  377074  377346
#>  [8992]  377909  378033  378167  378287  378706  378820  378953  378954  378955
#>  [9001]  378997  378998  379222  379223  379236  379237  379238  379239  379240
#>  [9010]  379241  379242  379243  379737  379738  379883  380292  380416  380495
#>  [9019]  380497  380498  380499  380500  380501  380502  380503  380504  380505
#>  [9028]  381056  381066  381427  381546  381941  381942  381964  381975  381989
#>  [9037]  381990  381991  382106  382107  382249  382289  382291  382295  382297
#>  [9046]  382313  382314  382343  382344  382392  382394  382438  382881  383049
#>  [9055]  383066  383067  383068  383069  383070  383071  383073  383074  383075
#>  [9064]  383076  383084  383085  383086  383087  383088  383089  383090  383091
#>  [9073]  383092  383093  383094  383095  383096  383097  383098  383099  383100
#>  [9082]  383101  383106  383108  383109  383110  383292  383343  383346  383348
#>  [9091]  383362  383363  383364  384077  384244  384698  384700  384721  384726
#>  [9100]  384731  384736  384934  384935  384936  384987  385124  385218  385258
#>  [9109]  385261  385360  385416  385423  385604  385780  385784  386235  386437
#>  [9118]  386438  386487  386489  386490  386491  386492  386494  386498  386574
#>  [9127]  386750  386752  387085  387115  387116  387147  387214  387245  387246
#>  [9136]  387248  387344  387365  387367  387369  387370  387371  387372  387373
#>  [9145]  387464  387491  387492  387558  387584  387585  387609  387859  387860
#>  [9154]  387872  388006  388010  388012  388025  388059  388060  388061  388065
#>  [9163]  388066  388096  388100  388101  388102  388103  388366  388376  388527
#>  [9172]  388538  388554  388664  388682  388684  388695  388696  388697  388699
#>  [9181]  388705  388794  388795  388945  389115  389121  389122  389174  389262
#>  [9190]  389263  389264  389301  389378  389400  389401  389402  389403  389434
#>  [9199]  389435  389436  389497  389764  389836  389837  389838  389839  389840
#>  [9208]  390580  390581  390582  390611  390695  390732  390733  390757  390793
#>  [9217]  390795  390807  391097  391169  391171  391200  391201  391202  391203
#>  [9226]  391217  391218  391219  391354  391356  391362  391365  391448  391449
#>  [9235]  391450  391451  391452  391453  391454  391455  391456  391457  391552
#>  [9244]  391553  391555  391584  391585  391616  391697  391705  391727  391728
#>  [9253]  391748  391992  392002  392048  392105  392142  392179  392394  392395
#>  [9262]  392408  392409  392477  392480  392485  392620  392621  392627  392628
#>  [9271]  392677  392709  392789  392790  392794  392799  392801  392803  392805
#>  [9280]  392807  392809  392852  392853  392870  392871  392873  392906  392907
#>  [9289]  392933  392946  392947  392948  393040  393070  393156  393162  393287
#>  [9298]  393296  393484  393964  393977  393978  393979  393980  393983  393984
#>  [9307]  393987  393988  393989  393990  393991  393992  393993  394177  394178
#>  [9316]  394180  394234  394250  394383  394384  394385  394386  394387  394446
#>  [9325]  394449  394450  394451  394455  394457  394656  394671  394804  394806
#>  [9334]  394810  394813  394826  394979  395059  395175  395281  395283  395302
#>  [9343]  395303  395304  395321  395498  395594  395595  395676  395677  395678
#>  [9352]  395817  395818  395849  395856  395857  395858  395896  395900  395908
#>  [9361]  395959  395960  395961  395962  396043  396044  396052  396054  396204
#>  [9370]  396205  396206  396235  396236  396237  396238  396239  396245  396246
#>  [9379]  396247  396248  396249  396250  396259  396260  396619  396690  396710
#>  [9388]  396775  396777  396792  396793  396860  396971  397034  397038  397046
#>  [9397]  397061  397062  397173  397177  397264  397269  397429  397431  397432
#>  [9406]  397434  397435  397436  397437  397587  397589  397590  397593  397596
#>  [9415]  397597  397598  397606  397607  397609  397755  397810  397906  397907
#>  [9424]  397973  397977  397992  397994  398315  398647  398703  399882  399940
#>  [9433]  400228  400266  400918  401232  401233  401234  402115  402473  402475
#>  [9442]  402667  403099  403100  403551  403580  403811  403970  403972  403973
#>  [9451]  403974  403997  404001  404158  404232  404236  404331  404402  404603
#>  [9460]  404606  404607  404830  404832  404834  404882  404883  404884  404885
#>  [9469]  404886  404891  404912  404979  404980  404985  404986  405124  405126
#>  [9478]  405382  405388  405389  405390  405391  405392  405398  405399  405401
#>  [9487]  405402  405403  405404  405412  405489  405490  405515  405938  406021
#>  [9496]  406022  406023  406024  406025  406026  406027  406211  406212  406215
#>  [9505]  406217  406228  406564  406566  406567  406568  406569  406570  406573
#>  [9514]  406576  406792  406926  406927  406928  407193  407204  407205  407643
#>  [9523]  407853  407854  407957  407958  407959  407960  407961  407962  408043
#>  [9532]  408044  408070  408086  408207  408210  408211  408212  408213  408214
#>  [9541]  408215  408404  408405  408406  408435  408543  408552  408740  408895
#>  [9550]  409408  409409  409410  409411  409414  409477  409672  409673  409674
#>  [9559]  409675  409678  409679  409809  409813  409815  410078  410081  410082
#>  [9568]  410083  410084  410085  410086  410127  410128  410129  410264  410265
#>  [9577]  410266  410342  410343  410344  410431  410449  410593  410598  410600
#>  [9586]  410601  410603  410604  410698  410699  410728  410731  410748  410751
#>  [9595]  410752  410753  410754  410755  410756  410757  410758  410759  410760
#>  [9604]  410945  410946  410947  410949  411047  411125  411258  411259  411260
#>  [9613]  411261  411262  411374  411375  411377  411378  411379  411380  411381
#>  [9622]  411516  411525  411649  411653  411790  411809  411826  411862  411904
#>  [9631]  411905  411908  411913  411919  412007  412009  412011  412013  412027
#>  [9640]  412029  412166  412168  412348  412349  412350  412354  412394  412395
#>  [9649]  412411  412438  412565  412566  412653  412786  412970  412981  413007
#>  [9658]  413009  413011  413250  413251  413257  413260  413263  413265  413266
#>  [9667]  413267  413268  413269  413270  413271  413272  413273  413275  413277
#>  [9676]  413551  413552  414283  414289  414291  414293  414295  414300  414302
#>  [9685]  414487  414488  414521  414527  414528  414569  414583  414609  414610
#>  [9694]  414611  414680  414707  414708  414709  414714  414719  414780  414781
#>  [9703]  414850  414852  414864  414865  414891  414892  414894  414895  414916
#>  [9712]  414917  414922  414923  414924  414925  414926  414935  415024  415035
#>  [9721]  415057  415063  415107  415108  415109  415245  415246  415247  415282
#>  [9730]  415283  415371  415385  415399  415400  415406  415409  415430  415440
#>  [9739]  415510  415511  415573  415685  415725  415994  416324  416385  416431
#>  [9748]  416432  416438  416439  416440  416441  416614  416615  416616  416617
#>  [9757]  416622  416623  416624  416625  416626  416627  416628  416629  416630
#>  [9766]  416631  416748  416749  416750  416751  416766  416767  416768  416769
#>  [9775]  416770  416771  416773  416774  416775  416776  416777  416780  416781
#>  [9784]  416782  416783  416784  416785  416787  416788  416990  417010  417011
#>  [9793]  417012  417093  417150  417151  417152  417156  417158  417160  417574
#>  [9802]  417575  417583  417584  417586  417598  417599  417600  417849  417850
#>  [9811]  417878  417879  417880  417938  417943  417951  417953  418053  418058
#>  [9820]  418186  418223  418224  418226  418227  418232  418285  418287  418330
#>  [9829]  418425  418426  418427  418688  418690  418705  418782  418785  418786
#>  [9838]  418787  418803  418805  418828  418829  418831  418871  418911  418920
#>  [9847]  418921  418922  419009  419011  419022  419029  419201  419214  419647
#>  [9856]  419648  419649  419653  419655  419656  419657  419658  419659  419661
#>  [9865]  419662  419664  419665  419666  419667  419668  419857  420101  420360
#>  [9874]  420365  420378  420383  420400  420401  420407  420427  420537  420542
#>  [9883]  420690  420691  420714  420715  420719  420806  420807  420808  420809
#>  [9892]  420810  420811  420812  420858  420864  420990  420991  420992  421012
#>  [9901]  421013  421049  421050  421051  421055  421056  421420  421421  421422
#>  [9910]  421423  421424  421559  421797  421892  421895  421896  421968  422082
#>  [9919]  422084  422156  422157  422171  422172  422173  422174  422205  422206
#>  [9928]  422211  422398  422516  422606  422608  422610  422612  422614  422616
#>  [9937]  422618  422619  422620  422621  422624  422830  422831  422832  422833
#>  [9946]  422834  422835  422836  422837  423157  423158  423275  423277  423278
#>  [9955]  423280  423442  423443  423444  423445  423469  423470  423471  423472
#>  [9964]  423473  423478  423479  423480  423481  423535  423657  423660  423661
#>  [9973]  423662  423667  423668  423669  423676  423677  423678  423679  423680
#>  [9982]  423696  423699  423700  423701  423702  423783  423785  423786  423787
#>  [9991]  423788  423789  423840  423869  423882  423887  423889  423897  423901
#> [10000]  423981  424015  424016  424039  424040  424136  424137  424138  424139
#> [10009]  424140  424141  424142  424143  424144  424145  424146  424147  424148
#> [10018]  424149  424150  424151  424152  424153  424154  424155  424156  424157
#> [10027]  424158  424159  424202  424229  424262  424434  424435  424436  424494
#> [10036]  424496  424663  424751  424755  424922  424924  424926  425006  425039
#> [10045]  425205  425295  425301  425302  425418  425420  425423  425424  425694
#> [10054]  425883  425894  426069  426144  426159  426234  426614  426823  426824
#> [10063]  426827  426889  426893  426894  426895  426896  426897  426898  427140
#> [10072]  427346  427347  427549  427550  427551  427552  427553  427554  427555
#> [10081]  427556  427557  427717  427722  427868  427907  427908  427909  427960
#> [10090]  427962  427967  427975  428033  428034  428035  428067  428151  428191
#> [10099]  428323  428324  428325  428326  428490  428502  428657  428658  428659
#> [10108]  428660  428661  428662  428663  428668  428947  428948  428949  429158
#> [10117]  429159  429160  429196  429197  429198  429199  429200  429281  429468
#> [10126]  429469  429504  429597  429598  429599  429600  429825  429980  430055
#> [10135]  430069  430070  430071  430077  430203  430204  430606  430785  431045
#> [10144]  431276  431380  431395  431396  431398  431399  431445  431551  431578
#> [10153]  431580  431582  431585  431586  431587  431588  431589  431591  431593
#> [10162]  431594  431595  431597  431598  431599  431600  431601  431602  431603
#> [10171]  431604  431605  431606  431607  431608  431609  431610  431611  431619
#> [10180]  431620  431624  431625  431627  431628  431629  431632  431633  431635
#> [10189]  431668  431688  431701  431807  431933  432215  432228  432331  432347
#> [10198]  432349  432355  432358  432359  432389  432390  432391  432392  432393
#> [10207]  432394  432395  432396  432402  432405  432407  432519  432564  432569
#> [10216]  432685  432728  432914  432915  432916  432917  432918  432919  432920
#> [10225]  432921  432922  432941  432943  432944  432948  433086  433087  433088
#> [10234]  433099  433264  433266  433285  433730  433738  433752  433757  433758
#> [10243]  433765  434184  434828  434829  434831  434923  434924  434928  434930
#> [10252]  434932  434935  434937  434938  434940  434941  434942  434943  434944
#> [10261]  434945  434946  434947  434951  434954  434968  435004  435010  435014
#> [10270]  435016  435023  435026  436095  436096  436251  436252  436253  436279
#> [10279]  436313  436349  436350  436399  436400  436410  436478  436479  436480
#> [10288]  436482  436483  436484  436486  436591  436717  436718  436910  436913
#> [10297]  436916  437089  437091  437342  437505  437514  437527  437551  437598
#> [10306]  437600  437699  437700  437701  437702  437724  437725  437771  437788
#> [10315]  437790  438025  438027  438032  438033  438044  438047  438208  438210
#> [10324]  438211  438212  438238  438239  438337  438338  438339  438409  438585
#> [10333]  438595  438789  438890  438893  438901  438906  438908  439326  439331
#> [10342]  439333  439369  439370  439463  439613  439616  439617  439882  439883
#> [10351]  440062  440066  440087  440232  440370  440375  440376  440377  440378
#> [10360]  440632  440633  440638  440639  440652  440654  440660  440661  440662
#> [10369]  440663  440664  440665  440666  440667  440668  440670  440671  440672
#> [10378]  440681  440682  440900  440901  441173  441241  441242  441276  441304
#> [10387]  441320  441321  441337  441372  441373  441378  441572  441573  441937
#> [10396]  441938  441939  441941  442204  442206  442210  442211  442212  442213
#> [10405]  442384  442385  442389  442704  442705  442706  442707  442708  442709
#> [10414]  442713  442948  443166  443169  443170  443171  443172  443173  443313
#> [10423]  443423  443424  443425  443456  443573  443586  443588  443590  443628
#> [10432]  443720  443750  443754  443755  443756  443757  443758  443759  443827
#> [10441]  443828  443829  443830  443831  443832  443842  443855  443911  443912
#> [10450]  443914  443986  443987  444093  444154  444181  444182  444227  444485
#> [10459]  444562  444563  444564  444761  444763  444894  444895  444900  444907
#> [10468]  444912  444914  444916  444918  444920  445047  445052  445053  445054
#> [10477]  445055  445056  445057  445058  445059  445060  445061  445062  445338
#> [10486]  445339  445340  445487  445525  445586  445589  445590  445745  445768
#> [10495]  445769  445832  445833  445835  445841  445879  445918  445919  445920
#> [10504]  445921  445928  445957  445959  445976  446019  446072  446092  446215
#> [10513]  446221  446400  446402  446479  446480  446485  446537  446540  446768
#> [10522]  446886  446904  446911  446912  446956  446984  447026  447027  447033
#> [10531]  447034  447035  447036  447037  447038  447290  447291  447385  447386
#> [10540]  447387  447388  447389  447449  447479  447480  447492  447496  447497
#> [10549]  447498  447499  447500  447501  447559  447562  447576  447581  447669
#> [10558]  447696  447701  447702  447901  447902  448097  448099  448104  448131
#> [10567]  448343  448344  448364  448369  448370  448371  448449  448485  448677
#> [10576]  449004  449010  449012  449013  449186  449188  449189  449193  449288
#> [10585]  449290  449296  449299  449408  449409  449489  449490  449703  449704
#> [10594]  449707  449708  449709  449710  449711  449712  449713  449714  449715
#> [10603]  449716  449717  449718  449719  449720  449721  449722  449737  449753
#> [10612]  449765  449766  449769  449770  450021  450023  450025  450027  450059
#> [10621]  450061  450063  450065  450071  450300  450301  450502  450503  450664
#> [10630]  450677  450678  450682  450683  450962  450963  450966  451325  451329
#> [10639]  451330  451331  451332  451333  451334  451335  451336  451337  451814
#> [10648]  451816  451968  451981  451983  451990  452021  452025  452028  452037
#> [10657]  452150  452223  452237  452269  452447  452529  452531  452533  452535
#> [10666]  452545  452551  452669  452720  452764  452780  452782  452863  452866
#> [10675]  452962  452963  452966  452971  452973  452974  452998  453000  453001
#> [10684]  453003  453067  453408  453409  453410  453411  453458  453481  453561
#> [10693]  453567  453571  453681  453683  453700  453978  453986  453987  453988
#> [10702]  453989  453990  453995  453997  453998  453999  454000  454001  454002
#> [10711]  454011  454012  454215  454216  454332  454333  454334  454335  454336
#> [10720]  454345  454494  454516  454582  454584  454634  454635  454639  454640
#> [10729]  454765  454821  454927  454928  455162  455164  455197  455202  455204
#> [10738]  455211  455242  455243  455265  455266  455458  455477  455478  455485
#> [10747]  455565  455566  455567  455568  455571  455705  455706  455831  455962
#> [10756]  456116  456197  456235  456556  456858  456992  457059  457060  457125
#> [10765]  457174  457175  457176  457177  457411  457516  457517  457518  457777
#> [10774]  457778  457935  457936  457950  457956  458094  458098  458101  458102
#> [10783]  458170  458180  458315  458316  458317  458440  458441  458442  458478
#> [10792]  458521  458523  458524  458559  458576  458577  458599  458695  458696
#> [10801]  458697  458711  458712  458777  458788  458869  458870  458873  458905
#> [10810]  458906  459022  459056  459060  459061  459080  459113  459114  459115
#> [10819]  459127  459164  459165  459166  459167  459168  459507  459526  459528
#> [10828]  459530  459534  459536  459538  460129  460296  460418  460573  460575
#> [10837]  460576  460652  460742  460811  460812  460814  460815  460816  460829
#> [10846]  460831  460887  460889  461025  461090  461108  461509  461562  461563
#> [10855]  461899  462312  462461  462465  462793  462795  462811  462812  462823
#> [10864]  463080  463086  463088  463103  463107  463108  463118  463120  463122
#> [10873]  463123  463125  463127  463128  463129  463150  463384  463385  463392
#> [10882]  463393  463611  463651  463755  463924  463926  463927  463981  463982
#> [10891]  463983  463988  463989  463990  463991  463992  463993  463994  463995
#> [10900]  463996  463997  463998  463999  464000  464001  464002  464037  464067
#> [10909]  464068  464069  464070  464071  464072  464225  464359  464438  464439
#> [10918]  464440  464441  464442  464640  464650  464691  464764  464765  464766
#> [10927]  464790  464842  464843  464844  464849  464862  464868  464869  464870
#> [10936]  464871  464872  464873  464893  465029  465418  465419  465420  465672
#> [10945]  465709  465710  465711  465712  465714  465966  466262  466263  466264
#> [10954]  466272  466802  466804  466805  466806  466917  466918  466919  466920
#> [10963]  466921  466922  466923  466924  467017  467282  467283  467395  467457
#> [10972]  467768  467780  467781  468160  468163  468214  468239  468242  468304
#> [10981]  468305  468974  468983  469025  469028  469031  469049  469066  469185
#> [10990]  469431  469518  469524  469713  469716  469722  469725  469730  469783
#> [10999]  469784  469785  469789  469797  469911  470071  470426  470427  470428
#> [11008]  470429  470430  470431  470432  470433  470434  470435  470436  470437
#> [11017]  470438  470439  470440  470441  470796  471095  471096  471097  471098
#> [11026]  471335  471336  471522  471525  471634  471635  471638  471639  471652
#> [11035]  471653  471654  471672  471673  471680  471681  471696  471699  471784
#> [11044]  472019  472075  472076  472468  472470  472472  472474  472476  472478
#> [11053]  472610  472789  472790  472791  472792  472793  472794  472795  472796
#> [11062]  472807  472811  472813  472961  473102  473107  473114  473115  473118
#> [11071]  473139  473151  473154  473155  473157  473208  473402  473423  473424
#> [11080]  473568  473667  473717  473718  473719  473720  473721  473722  473723
#> [11089]  473725  473726  474079  474081  474178  474194  474225  474229  474231
#> [11098]  474291  474325  474326  474328  474329  474331  474332  474334  474335
#> [11107]  474350  474351  474353  474354  474356  474357  474359  474360  474389
#> [11116]  474436  474438  474466  474665  474671  474672  474676  474677  474685
#> [11125]  474686  474788  474789  474844  474846  474942  475173  475233  475239
#> [11134]  475240  475241  475246  475318  475319  475325  475328  475329  475330
#> [11143]  475398  475399  475449  475450  475495  475853  475854  475855  475856
#> [11152]  475857  475858  475859  475862  475863  475864  475865  475866  475867
#> [11161]  475868  475869  475870  475871  475881  475882  475931  475975  475979
#> [11170]  475988  475989  475990  475991  476355  476357  476360  476362  476363
#> [11179]  476364  476365  476366  476367  476370  476371  476381  476382  476384
#> [11188]  476385  476386  476387  476388  476451  476463  476464  476469  476470
#> [11197]  476472  476560  476641  476642  476643  476644  476645  476646  476705
#> [11206]  476882  476898  476899  476900  476901  477112  477113  477115  477116
#> [11215]  477117  477118  477119  477120  477121  477122  477123  477124  477125
#> [11224]  477127  477128  477129  477132  477133  477135  477136  477137  477138
#> [11233]  477139  477140  477141  477142  477146  477147  477239  477240  477241
#> [11242]  477242  477243  477248  477249  477251  477252  477253  477254  477255
#> [11251]  477262  477263  477485  477515  477545  477546  477557  477558  477559
#> [11260]  477560  477845  477846  477847  477848  477849  477850  477851  477864
#> [11269]  478118  478119  478120  478121  478122  478123  478320  478321  478322
#> [11278]  478323  478324  478325  478379  478382  478385  478471  478473  478513
#> [11287]  478582  478586  478588  478590  478662  478663  478737  478877  478880
#> [11296]  478882  478884  478886  478888  478890  478909  478949  479097  479216
#> [11305]  479217  479219  479221  479373  479454  479481  479659  479789  479790
#> [11314]  479792  479933  479986  479987  479988  479992  479993  480053  480054
#> [11323]  480055  480056  480057  480058  480069  480149  480269  480270  480272
#> [11332]  480396  480398  480594  480975  480977  481112  481139  481140  481176
#> [11341]  481345  481346  481347  481415  481462  481464  481474  481517  481542
#> [11350]  481612  481616  481618  481619  481644  481645  481646  481647  481648
#> [11359]  481649  481650  481651  481653  481678  481679  481680  481683  481921
#> [11368]  481922  481923  481924  481925  482135  482136  482137  482138  482139
#> [11377]  482140  482141  482142  482143  482144  482145  482146  482147  482148
#> [11386]  482149  482150  482151  482349  482352  482355  482356  482428  482479
#> [11395]  482482  482498  482499  482500  482611  482612  482613  482659  482681
#> [11404]  482682  482683  482716  482741  482752  482763  482808  482874  482995
#> [11413]  483095  483121  483122  483123  483124  483125  483126  483142  483143
#> [11422]  483144  483145  483146  483149  483188  483557  483559  483560  483822
#> [11431]  483833  483903  484169  484311  484346  484352  484353  484354  484355
#> [11440]  484466  484467  484535  484595  484599  484614  484684  484694  484695
#> [11449]  484696  484697  484758  484773  484777  484782  484783  484784  484865
#> [11458]  484868  484883  484884  485277  485282  485284  485286  485352  485963
#> [11467]  485971  487137  487143  487144  487145  487146  487147  487438  487630
#> [11476]  487828  487832  487835  487878  488211  488212  488377  488378  488612
#> [11485]  488616  488695  488696  488697  488698  488699  488700  488702  488748
#> [11494]  488783  488790  488791  488792  488795  488801  488808  488811  488812
#> [11503]  488814  488817  488822  488823  488824  488825  488827  488833  488865
#> [11512]  488873  488875  488878  488880  488881  488886  488888  488985  488986
#> [11521]  489002  489003  489005  489013  489014  489024  489027  489032  489040
#> [11530]  489195  489229  489230  489231  489232  489247  489248  489311  489318
#> [11539]  489441  489479  489480  489481  489482  489483  489484  489485  489486
#> [11548]  489487  489488  489489  489490  489491  489492  489493  489541  489544
#> [11557]  489545  489546  489677  489678  489680  489909  490087  490199  490433
#> [11566]  490450  490451  490452  490453  490505  490506  490507  491140  491141
#> [11575]  491152  491214  491243  491476  491627  491644  491645  491646  491665
#> [11584]  491669  491672  491770  491826  491827  491828  491832  491833  491834
#> [11593]  491861  492041  492044  492047  492069  492211  492214  492276  492277
#> [11602]  492278  492281  492282  492283  492284  492285  492286  492287  492425
#> [11611]  492427  492500  492505  492515  492516  492517  492518  492520  492521
#> [11620]  492522  492525  492527  492535  492620  492621  492622  492745  492791
#> [11629]  492792  492815  492816  492862  492868  492875  492900  492905  492982
#> [11638]  492985  493021  493022  493023  493037  493038  493039  493041  493042
#> [11647]  493043  493044  493046  493047  493058  493060  493061  493112  493113
#> [11656]  493126  493128  493132  493133  493139  493145  493146  493183  493202
#> [11665]  493211  493223  493407  493441  493448  493465  493470  493471  493472
#> [11674]  493473  493477  493498  493527  493703  493783  493786  493789  493792
#> [11683]  493934  493935  494043  494046  494063  494067  494069  494071  494151
#> [11692]  494153  494206  494461  494468  494515  494632  494752  494753  494859
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#> [13366]  569829  569885  569905  569906  569947  569952  570069  570071  570137
#> [13375]  570173  570175  570176  570177  570178  570185  570218  570337  570339
#> [13384]  570341  570343  570553  570554  570555  570556  570557  570558  570559
#> [13393]  571512  571513  571514  571515  571516  571625  571626  571627  571628
#> [13402]  571629  571630  571631  571634  571635  571636  571637  571638  571700
#> [13411]  571701  571702  571736  572287  572288  572289  572290  572291  572292
#> [13420]  572315  572316  572319  572320  572334  572336  572819  572820  572821
#> [13429]  572822  572827  572828  572829  572856  572922  572923  572924  572925
#> [13438]  572952  572953  572954  572955  572956  572957  572958  572959  573108
#> [13447]  573109  573110  573111  573472  573473  573474  573475  573476  573477
#> [13456]  573478  573479  573849  573850  573851  573852  573853  573854  573855
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#> [38098] 1941179 1941180 1941191 1941207 1941219 1941354 1941357 1941358 1941359
#> [38107] 1941592 1941602 1941605 1942006 1942038 1942039 1942232 1942235 1942239
#> [38116] 1942296 1942297 1942307 1942340 1942341 1942456 1942534 1942535 1942536
#> [38125] 1942537 1942540 1942541 1942542 1942543 1942544 1942545 1942547 1942549
#> [38134] 1942550 1942551 1942554 1942555 1942556 1942558 1942673 1942674 1942675
#> [38143] 1942685 1942759 1942762 1942765 1942768 1942771 1942850 1942863 1942867
#> [38152] 1942868 1942869 1942870 1942871 1942872 1942874 1942885 1942887 1942888
#> [38161] 1942889 1942890 1942891 1942892 1942893 1942894 1942895 1942896 1942905
#> [38170] 1942979 1942980 1942981 1943213 1943217 1943219 1943254 1943255 1943266
#> [38179] 1943324 1943325 1943410 1943416 1943451 1943469 1943520 1943548 1943579
#> [38188] 1943678 1943686 1943687 1943689 1943707 1943716 1943717 1943718 1943719
#> [38197] 1943720 1943721 1943737 1943742 1943744 1943746 1943750 1943761 1943766
#> [38206] 1943769 1943779 1943781 1944002 1944004 1944015 1944016 1944018 1944019
#> [38215] 1944020 1944028 1944029 1944036 1944037 1944040 1944042 1944043 1944044
#> [38224] 1944046 1944047 1944049 1944053 1944356 1944972 1944974 1944976 1944977
#> [38233] 1944978 1944979 1944980 1944981 1944983 1944984 1944985 1944986 1944987
#> [38242] 1944990 1945227 1945228 1945314 1945409 1945412 1945569 1945570 1945627
#> [38251] 1945640 1946225 1946226 1946227 1946228 1946229 1946230 1946231 1946232
#> [38260] 1946238 1946239 1946240 1946241 1946242 1946245 1946246 1946247 1946250
#> [38269] 1946251 1946252 1946254 1946255 1946256 1946257 1946258 1946259 1946260
#> [38278] 1946262 1946267 1946268 1946334 1946335 1946336 1946344 1946535 1946679
#> [38287] 1946681 1946698 1946775 1946884 1946886 1946932 1946933 1946937 1946938
#> [38296] 1946939 1946947 1946948 1946949 1946950 1947110 1947113 1947190 1947191
#> [38305] 1947213 1947214 1947439 1947440 1947558 1947560 1947562 1947576 1947586
#> [38314] 1947792 1948112 1948128 1948129 1948130 1948131 1948132 1948133 1948134
#> [38323] 1948135 1948136 1948137 1948138 1948139 1948140 1948141 1948142 1948143
#> [38332] 1948144 1948145 1948408 1948459 1948460 1948461 1948462 1948525 1948685
#> [38341] 1948728 1948803 1949096 1949097 1949098 1949099 1949100 1949101 1949102
#> [38350] 1949103 1949110 1949111 1949112 1949113 1949114 1949115 1949116 1949117
#> [38359] 1949132 1949133 1949137 1949174 1949185 1949263 1949264 1949279 1949280
#> [38368] 1949281 1949282 1949283 1949284 1949285 1949286 1949287 1949288 1949291
#> [38377] 1949292 1949293 1949294 1949359 1949431 1949521 1949572 1949573 1949574
#> [38386] 1949576 1949577 1949578 1949579 1949607 1949626 1949676 1949685 1949713
#> [38395] 1949714 1949715 1949716 1949717 1949732 1949733 1949734 1949735 1949736
#> [38404] 1949737 1949744 1949745 1949750 1949758 1949761 1949762 1949763 1949773
#> [38413] 1949792 1949902 1949905 1949907 1949909 1949910 1949912 1949917 1949918
#> [38422] 1949919 1949969 1949970 1950242 1950243 1950257 1950264 1950265 1950266
#> [38431] 1950267 1950269 1950270 1950271 1950773 1950793 1950832 1950833 1950846
#> [38440] 1950847 1950848 1950849 1950850 1950851 1950867 1950868 1950871 1950872
#> [38449] 1950875 1950876 1950879 1950881 1950883 1951044 1951045 1951066 1951067
#> [38458] 1951075 1951076 1951078 1951104 1951105 1951107 1951108 1951109 1951174
#> [38467] 1951263 1951264 1951337 1951421 1951422 1951423 1951424 1951425 1951510
#> [38476] 1951541 1951639 1951642 1951645 1951648 1951651 1951654 1951657 1951660
#> [38485] 1951663 1951666 1951669 1951672 1951675 1951975 1951977 1952154 1952157
#> [38494] 1952162 1952163 1952166 1952168 1952173 1952174 1952176 1952177 1952452
#> [38503] 1952454 1952676 1952677 1952678 1952679 1952680 1952681 1952682 1952683
#> [38512] 1952684 1952685 1952686 1952687 1952689 1952697 1952698 1952699 1952700
#> [38521] 1952716 1952815 1952831 1952834 1952862 1952916 1952945 1952949 1953300
#> [38530] 1953301 1953311 1953332 1953411 1953412 1953584 1953609 1953610 1953611
#> [38539] 1953612 1953728 1953745 1953746 1953749 1953752 1953753 1953754 1953755
#> [38548] 1953756 1953768 1953769 1953770 1953771 1953788 1953792 1953797 1953801
#> [38557] 1953803 1953812 1953814 1953818 1953820 1953824 1954051 1954052 1954053
#> [38566] 1954063 1954064 1954065 1954066 1954067 1954068 1954069 1954070 1954071
#> [38575] 1954075 1954080 1954081 1954087 1954090 1954091 1954092 1954097 1954098
#> [38584] 1954100 1954103 1954104 1954112 1954114 1954225 1954226 1954227 1954228
#> [38593] 1954229 1954230 1954231 1954232 1954233 1954235 1954237 1954327 1954328
#> [38602] 1954581 1954676 1954679 1954680 1954682 1954826 1954828 1954846 1954854
#> [38611] 1954856 1954857 1954858 1954861 1955045 1955063 1955065 1955068 1955069
#> [38620] 1955071 1955078 1955079 1955080 1955081 1955082 1955440 1955486 1955487
#> [38629] 1955488 1955489 1955490 1955491 1955492 1955493 1955495 1955496 1955504
#> [38638] 1955505 1955510 1955511 1955516 1955517 1955522 1955523 1955524 1955525
#> [38647] 1955532 1955534 1955538 1955539 1955540 1955541 1955542 1955543 1955544
#> [38656] 1955545 1955557 1955570 1955571 1955572 1955576 1955577 1955578 1955579
#> [38665] 1955580 1955581 1955582 1955583 1955584 1955585 1955586 1955587 1955635
#> [38674] 1955642 1955643 1955644 1955820 1956008 1956114 1956116 1956124 1956127
#> [38683] 1956131 1956134 1956257 1956347 1956348 1956458 1956459 1956460 1956473
#> [38692] 1956510 1956641 1956642 1956643 1956644 1956645 1956646 1956647 1956648
#> [38701] 1956649 1956650 1956651 1956819 1957003 1957006 1957007 1957013 1957046
#> [38710] 1957056 1957087 1957156 1957195 1957224 1957225 1957226 1957227 1957228
#> [38719] 1957229 1957230 1957231 1957249 1957250 1957290 1957439 1957528 1957532
#> [38728] 1957533 1957543 1959096 1959123 1959169 1959170 1959182 1959184 1959185
#> [38737] 1959186 1959356 1959375 1959380 1959556 1959679 1959700 1959701 1959768
#> [38746] 1959769 1959771 1959794 1959913 1959914 1959916 1959917 1959918 1959919
#> [38755] 1960099 1960105 1960107 1960417 1960449 1960450 1960455 1960456 1960457
#> [38764] 1960458 1960581 1960582 1960583 1960710 1960724 1960918 1960919 1960920
#> [38773] 1960921 1960922 1960923 1960924 1960925 1960926 1960927 1960928 1960929
#> [38782] 1960930 1960931 1960935 1960938 1960940 1960941 1960942 1961203 1961347
#> [38791] 1961349 1961531 1961606 1961607 1961608 1961609 1961611 1961614 1961617
#> [38800] 1961619 1961622 1961648 1962465 1963009 1963010 1963012 1963014 1963016
#> [38809] 1963018 1963020 1963022 1963024 1963026 1963028 1963030 1963032 1963034
#> [38818] 1963036 1963038 1963040 1963042 1963044 1963046 1963048 1963050 1963052
#> [38827] 1963054 1963056 1963060 1963063 1963065 1963067 1963070 1963075 1963077
#> [38836] 1963116 1963117 1963118 1963119 1963120 1963121 1963122 1963124 1963126
#> [38845] 1963128 1963130 1963132 1963134 1963136 1963138 1963140 1963146 1963155
#> [38854] 1963157 1963163 1963165 1963171 1963174 1963176 1963178 1963180 1963182
#> [38863] 1963184 1963186 1963187 1963189 1963191 1963195 1963196 1963198 1963205
#> [38872] 1963207 1963213 1963214 1963219 1963222 1963224 1963226 1963228 1963230
#> [38881] 1963232 1963234 1963235 1963237 1963239 1963243 1963244 1963246 1963253
#> [38890] 1963255 1963262 1963263 1963268 1963287 1963288 1963326 1963327 1963328
#> [38899] 1963329 1963330 1963331 1963332 1963333 1963337 1963341 1963352 1963353
#> [38908] 1963354 1963370 1963383 1963386 1963395 1963396 1963398 1963401 1963402
#> [38917] 1963405 1963407 1963408 1963409 1963459 1963461 1963462 1963463 1963464
#> [38926] 1963468 1963471 1963473 1963474 1963475 1963480 1963506 1963528 1963534
#> [38935] 1963539 1963599 1963623

These examples demonstrate the flexibility of PUG REST in accessing specific BioAssay data. Users can efficiently retrieve detailed descriptions, comprehensive data sets, concise readouts, and target information, making it a valuable tool for researchers and scientists working with BioAssay data.

3.4. Genes

PubChem provides various methods to access gene data, making it a valuable resource for genetic research. Here’s how you can utilize PUG REST to access gene-related information:

1. Gene Input Methods:

  • By Gene ID: Access gene data using NCBI Gene identifiers. For example, to get a summary for gene IDs 1956 and 13649 in JSON format:
result <- get_pug_rest(identifier = "1956,13649", namespace = "geneid", domain = "gene", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: 1956,13649
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#> 
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#>  [1] "ERBB"                                                          
#>  [2] "ERBB1"                                                         
#>  [3] "ERRP"                                                          
#>  [4] "HER1"                                                          
#>  [5] "NISBD2"                                                        
#>  [6] "NNCIS"                                                         
#>  [7] "PIG61"                                                         
#>  [8] "mENA"                                                          
#>  [9] "EGFR vIII"                                                     
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"                             
#> [12] "cell proliferation-inducing protein 61"                        
#> [13] "epidermal growth factor receptor tyrosine kinase domain"       
#> [14] "erb-b2 receptor tyrosine kinase 1"                             
#> [15] "proto-oncogene c-ErbB-1"                                       
#> [16] "receptor tyrosine-protein kinase erbB-1"                       
#> 
#> 
#> $GeneSummaries$GeneSummary[[2]]
#> $GeneSummaries$GeneSummary[[2]]$GeneID
#> [1] 13649
#> 
#> $GeneSummaries$GeneSummary[[2]]$Symbol
#> [1] "Egfr"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[2]]$TaxonomyID
#> [1] 10090
#> 
#> $GeneSummaries$GeneSummary[[2]]$Taxonomy
#> [1] "Mus musculus (house mouse)"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Description
#> [1] ""
#> 
#> $GeneSummaries$GeneSummary[[2]]$Synonym
#> [1] "9030024J15Rik"                                                 
#> [2] "Erbb"                                                          
#> [3] "Errb1"                                                         
#> [4] "Errp"                                                          
#> [5] "Wa5"                                                           
#> [6] "wa-2"                                                          
#> [7] "wa2"                                                           
#> [8] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [9] "waved 2"
  • By Gene Symbol: Use the official gene symbol, which often maps to multiple genes. For example, to access data for the EGFR gene symbol:
result <- get_pug_rest(identifier = "EGFR", namespace = "genesymbol", domain = "gene", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: EGFR
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#> 
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#>  [1] "ERBB"                                                          
#>  [2] "ERBB1"                                                         
#>  [3] "ERRP"                                                          
#>  [4] "HER1"                                                          
#>  [5] "NISBD2"                                                        
#>  [6] "NNCIS"                                                         
#>  [7] "PIG61"                                                         
#>  [8] "mENA"                                                          
#>  [9] "EGFR vIII"                                                     
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"                             
#> [12] "cell proliferation-inducing protein 61"                        
#> [13] "epidermal growth factor receptor tyrosine kinase domain"       
#> [14] "erb-b2 receptor tyrosine kinase 1"                             
#> [15] "proto-oncogene c-ErbB-1"                                       
#> [16] "receptor tyrosine-protein kinase erbB-1"
  • By Gene Synonym: Access gene data using synonyms like alternative names. For example, for the ERBB1 synonym:
result <- get_pug_rest(identifier = "ERBB1", namespace = "synonym", domain = "gene", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: ERBB1
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#> 
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#>  [1] "ERBB"                                                          
#>  [2] "ERBB1"                                                         
#>  [3] "ERRP"                                                          
#>  [4] "HER1"                                                          
#>  [5] "NISBD2"                                                        
#>  [6] "NNCIS"                                                         
#>  [7] "PIG61"                                                         
#>  [8] "mENA"                                                          
#>  [9] "EGFR vIII"                                                     
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"                             
#> [12] "cell proliferation-inducing protein 61"                        
#> [13] "epidermal growth factor receptor tyrosine kinase domain"       
#> [14] "erb-b2 receptor tyrosine kinase 1"                             
#> [15] "proto-oncogene c-ErbB-1"                                       
#> [16] "receptor tyrosine-protein kinase erbB-1"                       
#> 
#> 
#> $GeneSummaries$GeneSummary[[2]]
#> $GeneSummaries$GeneSummary[[2]]$GeneID
#> [1] 24329
#> 
#> $GeneSummaries$GeneSummary[[2]]$Symbol
#> [1] "Egfr"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[2]]$TaxonomyID
#> [1] 10116
#> 
#> $GeneSummaries$GeneSummary[[2]]$Taxonomy
#> [1] "Rattus norvegicus (Norway rat)"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Description
#> [1] "promotes cell proliferation and differentiation; mediates GPCR regulated induction of protein synthesis [RGD, Feb 2006]"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Synonym
#> [1] "ERBB1"                                                                                                           
#> [2] "ErbB-1"                                                                                                          
#> [3] "Errp"                                                                                                            
#> [4] "EGFR-related peptide"                                                                                            
#> [5] "Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)" 
#> [6] "avian erythroblastic leukemia viral (v-erbB) oncogene homolog"                                                   
#> [7] "epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)"
#> 
#> 
#> $GeneSummaries$GeneSummary[[3]]
#> $GeneSummaries$GeneSummary[[3]]$GeneID
#> [1] 724072
#> 
#> $GeneSummaries$GeneSummary[[3]]$Symbol
#> [1] "egfr.L"
#> 
#> $GeneSummaries$GeneSummary[[3]]$Name
#> [1] "epidermal growth factor receptor L homeolog"
#> 
#> $GeneSummaries$GeneSummary[[3]]$TaxonomyID
#> [1] 8355
#> 
#> $GeneSummaries$GeneSummary[[3]]$Taxonomy
#> [1] "Xenopus laevis (African clawed frog)"
#> 
#> $GeneSummaries$GeneSummary[[3]]$Description
#> [1] ""
#> 
#> $GeneSummaries$GeneSummary[[3]]$Synonym
#> [1] "XEgfr"                            "egfr"                            
#> [3] "erbb"                             "erbb1"                           
#> [5] "her1"                             "epidermal growth factor receptor"
#> 
#> 
#> $GeneSummaries$GeneSummary[[4]]
#> $GeneSummaries$GeneSummary[[4]]$GeneID
#> [1] 100492965
#> 
#> $GeneSummaries$GeneSummary[[4]]$Symbol
#> [1] "egfr"
#> 
#> $GeneSummaries$GeneSummary[[4]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[4]]$TaxonomyID
#> [1] 8364
#> 
#> $GeneSummaries$GeneSummary[[4]]$Taxonomy
#> [1] "Xenopus tropicalis (tropical clawed frog)"
#> 
#> $GeneSummaries$GeneSummary[[4]]$Description
#> [1] ""
#> 
#> $GeneSummaries$GeneSummary[[4]]$Synonym
#> [1] "XEgfr" "erbb"  "erbb1" "her1" 
#> 
#> 
#> $GeneSummaries$GeneSummary[[5]]
#> $GeneSummaries$GeneSummary[[5]]$GeneID
#> [1] 100537376
#> 
#> $GeneSummaries$GeneSummary[[5]]$Symbol
#> [1] "egfrb"
#> 
#> $GeneSummaries$GeneSummary[[5]]$Name
#> [1] "epidermal growth factor receptor b (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)"
#> 
#> $GeneSummaries$GeneSummary[[5]]$TaxonomyID
#> [1] 7955
#> 
#> $GeneSummaries$GeneSummary[[5]]$Taxonomy
#> [1] "Danio rerio (zebrafish)"
#> 
#> $GeneSummaries$GeneSummary[[5]]$Description
#> [1] ""
#> 
#> $GeneSummaries$GeneSummary[[5]]$Synonym
#> [1] "erbb1"  "erbb1b"
#> 
#> 
#> $GeneSummaries$GeneSummary[[6]]
#> $GeneSummaries$GeneSummary[[6]]$GeneID
#> [1] 108719997
#> 
#> $GeneSummaries$GeneSummary[[6]]$Symbol
#> [1] "egfr.S"
#> 
#> $GeneSummaries$GeneSummary[[6]]$Name
#> [1] "epidermal growth factor receptor S homeolog"
#> 
#> $GeneSummaries$GeneSummary[[6]]$TaxonomyID
#> [1] 8355
#> 
#> $GeneSummaries$GeneSummary[[6]]$Taxonomy
#> [1] "Xenopus laevis (African clawed frog)"
#> 
#> $GeneSummaries$GeneSummary[[6]]$Description
#> [1] ""
#> 
#> $GeneSummaries$GeneSummary[[6]]$Synonym
#> [1] "XEgfr"                            "erbb"                            
#> [3] "erbb1"                            "her1"                            
#> [5] "epidermal growth factor receptor"

2. Available Gene Data:

  • Gene Summary: Returns a summary including GeneID, Symbol, Name, TaxonomyID, Description, and Synonyms. For example:
result <- get_pug_rest(identifier = "1956,13649", namespace = "geneid", domain = "gene", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: 1956,13649
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $GeneSummaries
#> $GeneSummaries$GeneSummary
#> $GeneSummaries$GeneSummary[[1]]
#> $GeneSummaries$GeneSummary[[1]]$GeneID
#> [1] 1956
#> 
#> $GeneSummaries$GeneSummary[[1]]$Symbol
#> [1] "EGFR"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $GeneSummaries$GeneSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Description
#> [1] "The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]"
#> 
#> $GeneSummaries$GeneSummary[[1]]$Synonym
#>  [1] "ERBB"                                                          
#>  [2] "ERBB1"                                                         
#>  [3] "ERRP"                                                          
#>  [4] "HER1"                                                          
#>  [5] "NISBD2"                                                        
#>  [6] "NNCIS"                                                         
#>  [7] "PIG61"                                                         
#>  [8] "mENA"                                                          
#>  [9] "EGFR vIII"                                                     
#> [10] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [11] "cell growth inhibiting protein 40"                             
#> [12] "cell proliferation-inducing protein 61"                        
#> [13] "epidermal growth factor receptor tyrosine kinase domain"       
#> [14] "erb-b2 receptor tyrosine kinase 1"                             
#> [15] "proto-oncogene c-ErbB-1"                                       
#> [16] "receptor tyrosine-protein kinase erbB-1"                       
#> 
#> 
#> $GeneSummaries$GeneSummary[[2]]
#> $GeneSummaries$GeneSummary[[2]]$GeneID
#> [1] 13649
#> 
#> $GeneSummaries$GeneSummary[[2]]$Symbol
#> [1] "Egfr"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Name
#> [1] "epidermal growth factor receptor"
#> 
#> $GeneSummaries$GeneSummary[[2]]$TaxonomyID
#> [1] 10090
#> 
#> $GeneSummaries$GeneSummary[[2]]$Taxonomy
#> [1] "Mus musculus (house mouse)"
#> 
#> $GeneSummaries$GeneSummary[[2]]$Description
#> [1] ""
#> 
#> $GeneSummaries$GeneSummary[[2]]$Synonym
#> [1] "9030024J15Rik"                                                 
#> [2] "Erbb"                                                          
#> [3] "Errb1"                                                         
#> [4] "Errp"                                                          
#> [5] "Wa5"                                                           
#> [6] "wa-2"                                                          
#> [7] "wa2"                                                           
#> [8] "avian erythroblastic leukemia viral (v-erb-b) oncogene homolog"
#> [9] "waved 2"
  • Assays from Gene: Retrieves a list of AIDs tested against a specific gene. For example, for gene ID 13649:
result <- get_pug_rest(identifier = "13649", namespace = "geneid", domain = "gene", operation = "aids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: aids
#>   - Identifier: 13649
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>       Text
#> 1    66438
#> 2    69721
#> 3    69722
#> 4    69724
#> 5    69727
#> 6    69728
#> 7    69729
#> 8    69730
#> 9   106697
#> 10  209326
#> 11  241562
#> 12  241823
#> 13  337238
#> 14  337243
#> 15  337244
#> 16  415757
#> 17  415758
#> 18  415759
#> 19  415760
#> 20 1053208
#> 21 1224826
#> 22 1224828
#> 23 1527521
#> 24 1740135
#> 25 1815786
#> 26 1815820
#> 27 1862914
#> 28 1896806
  • Bioactivities from Gene: Returns concise bioactivity data for a specific gene. For example:
result <- get_pug_rest(identifier = "13649", namespace = "geneid", domain = "gene", operation = "concise", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: concise
#>   - Identifier: 13649
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#>  [1] "AID"                 "SID"                 "CID"                
#>  [4] "Activity Outcome"    "Target Accession"    "Activity Value [uM]"
#>  [7] "Activity Name"       "Assay Name"          "Assay Type"         
#> [10] "PubMed ID"           "RNAi"               
#> 
#> 
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#>  [1] "66438"                                                           
#>  [2] "103250953"                                                       
#>  [3] "25017867"                                                        
#>  [4] "Active"                                                          
#>  [5] "Q01279"                                                          
#>  [6] "0.01"                                                            
#>  [7] "Effective concentration"                                         
#>  [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#>  [9] "Confirmatory"                                                    
#> [10] "1597853"                                                         
#> [11] ""                                                                
#> 
#> 
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#>  [1] "66438"                                                           
#>  [2] "103432098"                                                       
#>  [3] "454217"                                                          
#>  [4] "Active"                                                          
#>  [5] "Q01279"                                                          
#>  [6] "0.22"                                                            
#>  [7] "Effective concentration"                                         
#>  [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#>  [9] "Confirmatory"                                                    
#> [10] "1597853"                                                         
#> [11] ""                                                                
#> 
#> 
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#>  [1] "69721"                                                                              
#>  [2] "103358917"                                                                          
#>  [3] "135512509"                                                                          
#>  [4] "Unspecified"                                                                        
#>  [5] "Q01279"                                                                             
#>  [6] "22.7"                                                                               
#>  [7] "IC50"                                                                               
#>  [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#>  [9] "Confirmatory"                                                                       
#> [10] "9748366"                                                                            
#> [11] ""                                                                                   
#> 
#> 
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#>  [1] "69721"                                                                              
#>  [2] "103358918"                                                                          
#>  [3] "135434086"                                                                          
#>  [4] "Unspecified"                                                                        
#>  [5] "Q01279"                                                                             
#>  [6] "36.9"                                                                               
#>  [7] "IC50"                                                                               
#>  [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#>  [9] "Confirmatory"                                                                       
#> [10] "9748366"                                                                            
#> [11] ""                                                                                   
#> 
#> 
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#>  [1] "69721"                                                                              
#>  [2] "103358919"                                                                          
#>  [3] "135455949"                                                                          
#>  [4] "Unspecified"                                                                        
#>  [5] "Q01279"                                                                             
#>  [6] "11.3"                                                                               
#>  [7] "IC50"                                                                               
#>  [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#>  [9] "Confirmatory"                                                                       
#> [10] "9748366"                                                                            
#> [11] ""                                                                                   
#> 
#> 
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103253186"                                                                                                       
#>  [3] "5328592"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "Q01279"                                                                                                          
#>  [6] "100"                                                                                                             
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> [11] ""                                                                                                                
#> 
#> 
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103253755"                                                                                                       
#>  [3] "5328614"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "Q01279"                                                                                                          
#>  [6] "100"                                                                                                             
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> [11] ""                                                                                                                
#> 
#> 
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103254313"                                                                                                       
#>  [3] "5328618"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "Q01279"                                                                                                          
#>  [6] "100"                                                                                                             
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> [11] ""                                                                                                                
#> 
#> 
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103254592"                                                                                                       
#>  [3] "5328617"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "Q01279"                                                                                                          
#>  [6] "25"                                                                                                              
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> [11] ""                                                                                                                
#> 
#> 
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103237764"                                                               
#>  [3] "5328042"                                                                 
#>  [4] "Active"                                                                  
#>  [5] "Q01279"                                                                  
#>  [6] "0.04"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> [11] ""                                                                        
#> 
#> 
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103373305"                                                               
#>  [3] "9882519"                                                                 
#>  [4] "Active"                                                                  
#>  [5] "Q01279"                                                                  
#>  [6] "0.2"                                                                     
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> [11] ""                                                                        
#> 
#> 
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103373788"                                                               
#>  [3] "9885081"                                                                 
#>  [4] "Active"                                                                  
#>  [5] "Q01279"                                                                  
#>  [6] "0.07"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> [11] ""                                                                        
#> 
#> 
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103399645"                                                               
#>  [3] "11198415"                                                                
#>  [4] "Active"                                                                  
#>  [5] "Q01279"                                                                  
#>  [6] "0.578"                                                                   
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> [11] ""                                                                        
#> 
#> 
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103399736"                                                               
#>  [3] "10094127"                                                                
#>  [4] "Active"                                                                  
#>  [5] "Q01279"                                                                  
#>  [6] "0.13"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> [11] ""                                                                        
#> 
#> 
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103399893"                                                               
#>  [3] "11349700"                                                                
#>  [4] "Active"                                                                  
#>  [5] "Q01279"                                                                  
#>  [6] "0.11"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> [11] ""                                                                        
#> 
#> 
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#>  [1] "69727"                                                                                  
#>  [2] "103167027"                                                                              
#>  [3] "5280343"                                                                                
#>  [4] "Unspecified"                                                                            
#>  [5] "Q01279"                                                                                 
#>  [6] ""                                                                                       
#>  [7] ""                                                                                       
#>  [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#>  [9] "Other"                                                                                  
#> [10] "8201603"                                                                                
#> [11] ""                                                                                       
#> 
#> 
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#>  [1] "69728"                                                                              
#>  [2] "103399857"                                                                          
#>  [3] "44368090"                                                                           
#>  [4] "Inactive"                                                                           
#>  [5] "Q01279"                                                                             
#>  [6] ""                                                                                   
#>  [7] ""                                                                                   
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK) (inactive)"
#>  [9] "Other"                                                                              
#> [10] "14640561"                                                                           
#> [11] ""                                                                                   
#> 
#> 
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#>  [1] "69729"                                                                                  
#>  [2] "103167027"                                                                              
#>  [3] "5280343"                                                                                
#>  [4] "Unspecified"                                                                            
#>  [5] "Q01279"                                                                                 
#>  [6] ""                                                                                       
#>  [7] ""                                                                                       
#>  [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#>  [9] "Other"                                                                                  
#> [10] "8201603"                                                                                
#> [11] ""                                                                                       
#> 
#> 
#> $Table$Row[[19]]
#> $Table$Row[[19]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103226434"                                                                                   
#>  [3] "10318571"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "Q01279"                                                                                      
#>  [6] "4"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[20]]
#> $Table$Row[[20]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103350640"                                                                                   
#>  [3] "10406106"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "14"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[21]]
#> $Table$Row[[21]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103378973"                                                                                   
#>  [3] "10738302"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "33"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[22]]
#> $Table$Row[[22]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103378974"                                                                                   
#>  [3] "10761144"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "200"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[23]]
#> $Table$Row[[23]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379003"                                                                                   
#>  [3] "10044189"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "500"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[24]]
#> $Table$Row[[24]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379199"                                                                                   
#>  [3] "10428841"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "Q01279"                                                                                      
#>  [6] "8"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[25]]
#> $Table$Row[[25]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379200"                                                                                   
#>  [3] "10716388"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "100"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[26]]
#> $Table$Row[[26]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379360"                                                                                   
#>  [3] "10452792"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "50"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[27]]
#> $Table$Row[[27]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379591"                                                                                   
#>  [3] "10620637"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "300"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[28]]
#> $Table$Row[[28]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379616"                                                                                   
#>  [3] "10593843"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "100"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[29]]
#> $Table$Row[[29]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379617"                                                                                   
#>  [3] "10787405"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "Q01279"                                                                                      
#>  [6] "4"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[30]]
#> $Table$Row[[30]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379660"                                                                                   
#>  [3] "10343317"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "35"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[31]]
#> $Table$Row[[31]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379661"                                                                                   
#>  [3] "10499929"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "15"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[32]]
#> $Table$Row[[32]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379682"                                                                                   
#>  [3] "10500718"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "Q01279"                                                                                      
#>  [6] "1"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[33]]
#> $Table$Row[[33]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379908"                                                                                   
#>  [3] "10619651"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "Q01279"                                                                                      
#>  [6] "10"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[34]]
#> $Table$Row[[34]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379909"                                                                                   
#>  [3] "10504027"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "35"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[35]]
#> $Table$Row[[35]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379910"                                                                                   
#>  [3] "10740438"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "Q01279"                                                                                      
#>  [6] "46"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> [11] ""                                                                                            
#> 
#> 
#> $Table$Row[[36]]
#> $Table$Row[[36]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166113"                                                           
#>  [3] "10499619"                                                            
#>  [4] "Active"                                                              
#>  [5] "Q01279"                                                              
#>  [6] "9.55"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[37]]
#> $Table$Row[[37]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166157"                                                           
#>  [3] "9978638"                                                             
#>  [4] "Active"                                                              
#>  [5] "Q01279"                                                              
#>  [6] "4.93"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[38]]
#> $Table$Row[[38]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166217"                                                           
#>  [3] "10590515"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "Q01279"                                                              
#>  [6] "45.2"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[39]]
#> $Table$Row[[39]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166266"                                                           
#>  [3] "10803234"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "Q01279"                                                              
#>  [6] "10.2"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[40]]
#> $Table$Row[[40]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166322"                                                           
#>  [3] "2051"                                                                
#>  [4] "Active"                                                              
#>  [5] "Q01279"                                                              
#>  [6] "0.1"                                                                 
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[41]]
#> $Table$Row[[41]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166323"                                                           
#>  [3] "10850934"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "Q01279"                                                              
#>  [6] "16"                                                                  
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[42]]
#> $Table$Row[[42]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166405"                                                           
#>  [3] "9883384"                                                             
#>  [4] "Active"                                                              
#>  [5] "Q01279"                                                              
#>  [6] "2.83"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[43]]
#> $Table$Row[[43]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166415"                                                           
#>  [3] "10494548"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "Q01279"                                                              
#>  [6] "11.4"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[44]]
#> $Table$Row[[44]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166416"                                                           
#>  [3] "689033"                                                              
#>  [4] "Unspecified"                                                         
#>  [5] "Q01279"                                                              
#>  [6] "46.2"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> [11] ""                                                                    
#> 
#> 
#> $Table$Row[[45]]
#> $Table$Row[[45]]$Cell
#>  [1] "209326"                                                   
#>  [2] "103257455"                                                
#>  [3] "2428"                                                     
#>  [4] "Active"                                                   
#>  [5] "Q01279"                                                   
#>  [6] "0.046"                                                    
#>  [7] "IC50"                                                     
#>  [8] "Inhibition of EGF-mediated mitogenesis in Swiss 3T3 cells"
#>  [9] "Confirmatory"                                             
#> [10] "8632415"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[46]]
#> $Table$Row[[46]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439646"                                                  
#>  [3] "10209082"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[47]]
#> $Table$Row[[47]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439659"                                                  
#>  [3] "10185160"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[48]]
#> $Table$Row[[48]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439663"                                                  
#>  [3] "10143584"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[49]]
#> $Table$Row[[49]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439672"                                                  
#>  [3] "10163439"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[50]]
#> $Table$Row[[50]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439700"                                                  
#>  [3] "10302405"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[51]]
#> $Table$Row[[51]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439717"                                                  
#>  [3] "10187378"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[52]]
#> $Table$Row[[52]]$Cell
#>  [1] "241562"                                                     
#>  [2] "123092436"                                                  
#>  [3] "44259"                                                      
#>  [4] "Unspecified"                                                
#>  [5] "Q01279"                                                     
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> [11] ""                                                           
#> 
#> 
#> $Table$Row[[53]]
#> $Table$Row[[53]]$Cell
#>  [1] "241823"                                                                             
#>  [2] "103452251"                                                                          
#>  [3] "22732319"                                                                           
#>  [4] "Inconclusive"                                                                       
#>  [5] "Q01279"                                                                             
#>  [6] ""                                                                                   
#>  [7] ""                                                                                   
#>  [8] "Inhibition of Epidermal growth factor receptor tyrosine kinase activity; not tested"
#>  [9] "Other"                                                                              
#> [10] "15454232"                                                                           
#> [11] ""                                                                                   
#> 
#> 
#> $Table$Row[[54]]
#> $Table$Row[[54]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103194285"                                                
#>  [3] "4075"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[55]]
#> $Table$Row[[55]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103227545"                                                
#>  [3] "5328552"                                                  
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[56]]
#> $Table$Row[[56]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103319670"                                                
#>  [3] "3894"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[57]]
#> $Table$Row[[57]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103319671"                                                
#>  [3] "3896"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[58]]
#> $Table$Row[[58]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103529702"                                                
#>  [3] "65083"                                                    
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[59]]
#> $Table$Row[[59]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103529722"                                                
#>  [3] "70949"                                                    
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[60]]
#> $Table$Row[[60]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618685"                                                
#>  [3] "3895"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[61]]
#> $Table$Row[[61]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618686"                                                
#>  [3] "44593598"                                                 
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[62]]
#> $Table$Row[[62]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618687"                                                
#>  [3] "44593599"                                                 
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[63]]
#> $Table$Row[[63]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618691"                                                
#>  [3] "375472"                                                   
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[64]]
#> $Table$Row[[64]]$Cell
#>  [1] "337238"                                                   
#>  [2] "123092436"                                                
#>  [3] "44259"                                                    
#>  [4] "Unspecified"                                              
#>  [5] "Q01279"                                                   
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> [11] ""                                                         
#> 
#> 
#> $Table$Row[[65]]
#> $Table$Row[[65]]$Cell
#>  [1] "337243"                                                                                        
#>  [2] "103319670"                                                                                     
#>  [3] "3894"                                                                                          
#>  [4] "Active"                                                                                        
#>  [5] "Q01279"                                                                                        
#>  [6] ""                                                                                              
#>  [7] ""                                                                                              
#>  [8] "Inhibition of mouse EGFR using [32P]gammaATP as substrate by competitive Lineweaver-Burke plot"
#>  [9] "Other"                                                                                         
#> [10] "2614420"                                                                                       
#> [11] ""                                                                                              
#> 
#> 
#> $Table$Row[[66]]
#> $Table$Row[[66]]$Cell
#>  [1] "337244"                                                                                           
#>  [2] "103319670"                                                                                        
#>  [3] "3894"                                                                                             
#>  [4] "Active"                                                                                           
#>  [5] "Q01279"                                                                                           
#>  [6] ""                                                                                                 
#>  [7] ""                                                                                                 
#>  [8] "Inhibition of mouse EGFR using tridecapeptide as substrate by uncompetitive Lineweaver-Burke plot"
#>  [9] "Other"                                                                                            
#> [10] "2614420"                                                                                          
#> [11] ""                                                                                                 
#> 
#> 
#> $Table$Row[[67]]
#> $Table$Row[[67]]$Cell
#>  [1] "415757"                                                                                  
#>  [2] "103294831"                                                                               
#>  [3] "5289418"                                                                                 
#>  [4] "Active"                                                                                  
#>  [5] "Q01279"                                                                                  
#>  [6] ""                                                                                        
#>  [7] ""                                                                                        
#>  [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#>  [9] "Other"                                                                                   
#> [10] "9139660"                                                                                 
#> [11] ""                                                                                        
#> 
#> 
#> $Table$Row[[68]]
#> $Table$Row[[68]]$Cell
#>  [1] "415757"                                                                                  
#>  [2] "103295395"                                                                               
#>  [3] "5941540"                                                                                 
#>  [4] "Active"                                                                                  
#>  [5] "Q01279"                                                                                  
#>  [6] ""                                                                                        
#>  [7] ""                                                                                        
#>  [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#>  [9] "Other"                                                                                   
#> [10] "9139660"                                                                                 
#> [11] ""                                                                                        
#> 
#> 
#> $Table$Row[[69]]
#> $Table$Row[[69]]$Cell
#>  [1] "415758"                                                                                                                
#>  [2] "103294831"                                                                                                             
#>  [3] "5289418"                                                                                                               
#>  [4] "Active"                                                                                                                
#>  [5] "Q01279"                                                                                                                
#>  [6] ""                                                                                                                      
#>  [7] ""                                                                                                                      
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#>  [9] "Other"                                                                                                                 
#> [10] "9139660"                                                                                                               
#> [11] ""                                                                                                                      
#> 
#> 
#> $Table$Row[[70]]
#> $Table$Row[[70]]$Cell
#>  [1] "415758"                                                                                                                
#>  [2] "103295395"                                                                                                             
#>  [3] "5941540"                                                                                                               
#>  [4] "Active"                                                                                                                
#>  [5] "Q01279"                                                                                                                
#>  [6] ""                                                                                                                      
#>  [7] ""                                                                                                                      
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#>  [9] "Other"                                                                                                                 
#> [10] "9139660"                                                                                                               
#> [11] ""                                                                                                                      
#> 
#> 
#> $Table$Row[[71]]
#> $Table$Row[[71]]$Cell
#>  [1] "415759"                                                                                                            
#>  [2] "103294831"                                                                                                         
#>  [3] "5289418"                                                                                                           
#>  [4] "Active"                                                                                                            
#>  [5] "Q01279"                                                                                                            
#>  [6] ""                                                                                                                  
#>  [7] ""                                                                                                                  
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#>  [9] "Other"                                                                                                             
#> [10] "9139660"                                                                                                           
#> [11] ""                                                                                                                  
#> 
#> 
#> $Table$Row[[72]]
#> $Table$Row[[72]]$Cell
#>  [1] "415759"                                                                                                            
#>  [2] "103295395"                                                                                                         
#>  [3] "5941540"                                                                                                           
#>  [4] "Active"                                                                                                            
#>  [5] "Q01279"                                                                                                            
#>  [6] ""                                                                                                                  
#>  [7] ""                                                                                                                  
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#>  [9] "Other"                                                                                                             
#> [10] "9139660"                                                                                                           
#> [11] ""                                                                                                                  
#> 
#> 
#> $Table$Row[[73]]
#> $Table$Row[[73]]$Cell
#>  [1] "415760"                                                             
#>  [2] "103294831"                                                          
#>  [3] "5289418"                                                            
#>  [4] "Inactive"                                                           
#>  [5] "Q01279"                                                             
#>  [6] ""                                                                   
#>  [7] ""                                                                   
#>  [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#>  [9] "Other"                                                              
#> [10] "9139660"                                                            
#> [11] ""                                                                   
#> 
#> 
#> $Table$Row[[74]]
#> $Table$Row[[74]]$Cell
#>  [1] "415760"                                                             
#>  [2] "103295395"                                                          
#>  [3] "5941540"                                                            
#>  [4] "Inactive"                                                           
#>  [5] "Q01279"                                                             
#>  [6] ""                                                                   
#>  [7] ""                                                                   
#>  [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#>  [9] "Other"                                                              
#> [10] "9139660"                                                            
#> [11] ""                                                                   
#> 
#> 
#> $Table$Row[[75]]
#> $Table$Row[[75]]$Cell
#>  [1] "1053208"                                                                                                         
#>  [2] "152302885"                                                                                                       
#>  [3] ""                                                                                                                
#>  [4] "Inactive"                                                                                                        
#>  [5] ""                                                                                                                
#>  [6] ""                                                                                                                
#>  [7] ""                                                                                                                
#>  [8] "A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen"
#>  [9] "Screening"                                                                                                       
#> [10] "25862761"                                                                                                        
#> [11] "1"                                                                                                               
#> 
#> 
#> $Table$Row[[76]]
#> $Table$Row[[76]]$Cell
#>  [1] "1224826"                                                                                                                                                      
#>  [2] "315466459"                                                                                                                                                    
#>  [3] ""                                                                                                                                                             
#>  [4] "Inactive"                                                                                                                                                     
#>  [5] ""                                                                                                                                                             
#>  [6] ""                                                                                                                                                             
#>  [7] ""                                                                                                                                                             
#>  [8] "Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout"
#>  [9] "Summary"                                                                                                                                                      
#> [10] ""                                                                                                                                                             
#> [11] "1"                                                                                                                                                            
#> 
#> 
#> $Table$Row[[77]]
#> $Table$Row[[77]]$Cell
#>  [1] "1224828"                                                                                                                                                       
#>  [2] "315466459"                                                                                                                                                     
#>  [3] ""                                                                                                                                                              
#>  [4] "Inactive"                                                                                                                                                      
#>  [5] ""                                                                                                                                                              
#>  [6] ""                                                                                                                                                              
#>  [7] ""                                                                                                                                                              
#>  [8] "Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout"
#>  [9] "Summary"                                                                                                                                                       
#> [10] ""                                                                                                                                                              
#> [11] "1"                                                                                                                                                             
#> 
#> 
#> $Table$Row[[78]]
#> $Table$Row[[78]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "312367127"                                                                                                                                                          
#>  [3] "71496458"                                                                                                                                                           
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "0.081"                                                                                                                                                              
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[79]]
#> $Table$Row[[79]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440110169"                                                                                                                                                          
#>  [3] "139593669"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "10"                                                                                                                                                                 
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[80]]
#> $Table$Row[[80]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440119817"                                                                                                                                                          
#>  [3] "155517202"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] ""                                                                                                                                                                   
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[81]]
#> $Table$Row[[81]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440125045"                                                                                                                                                          
#>  [3] "139447864"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "3.6"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[82]]
#> $Table$Row[[82]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440160302"                                                                                                                                                          
#>  [3] "139593670"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "1.3"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[83]]
#> $Table$Row[[83]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440163841"                                                                                                                                                          
#>  [3] "139447649"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "5.1"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[84]]
#> $Table$Row[[84]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440172005"                                                                                                                                                          
#>  [3] "139447554"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "0.7"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[85]]
#> $Table$Row[[85]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440176009"                                                                                                                                                          
#>  [3] "139600318"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "0.19"                                                                                                                                                               
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[86]]
#> $Table$Row[[86]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440182946"                                                                                                                                                          
#>  [3] "155444794"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "2.3"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[87]]
#> $Table$Row[[87]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440203081"                                                                                                                                                          
#>  [3] "155444797"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "1.1"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[88]]
#> $Table$Row[[88]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440207922"                                                                                                                                                          
#>  [3] "155444848"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "0.27"                                                                                                                                                               
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[89]]
#> $Table$Row[[89]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440227038"                                                                                                                                                          
#>  [3] "139593668"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] ""                                                                                                                                                                   
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[90]]
#> $Table$Row[[90]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "312367127"                                                                                                                                                          
#>  [3] "71496458"                                                                                                                                                           
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "2.6"                                                                                                                                                                
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[91]]
#> $Table$Row[[91]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461515468"                                                                                                                                                          
#>  [3] "162643657"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] ""                                                                                                                                                                   
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[92]]
#> $Table$Row[[92]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461515649"                                                                                                                                                          
#>  [3] "162643790"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "9.23"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[93]]
#> $Table$Row[[93]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461542097"                                                                                                                                                          
#>  [3] "162662364"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "3.91"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[94]]
#> $Table$Row[[94]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461543217"                                                                                                                                                          
#>  [3] "162663118"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[95]]
#> $Table$Row[[95]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461546315"                                                                                                                                                          
#>  [3] "162665339"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[96]]
#> $Table$Row[[96]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461547480"                                                                                                                                                          
#>  [3] "162666122"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "4.27"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[97]]
#> $Table$Row[[97]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461549927"                                                                                                                                                          
#>  [3] "162667840"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "3.79"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[98]]
#> $Table$Row[[98]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461550238"                                                                                                                                                          
#>  [3] "162668052"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "2.65"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[99]]
#> $Table$Row[[99]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461550466"                                                                                                                                                          
#>  [3] "162668204"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[100]]
#> $Table$Row[[100]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461555362"                                                                                                                                                          
#>  [3] "162671649"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] ""                                                                                                                                                                   
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[101]]
#> $Table$Row[[101]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461557317"                                                                                                                                                          
#>  [3] "162673094"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "9.23"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[102]]
#> $Table$Row[[102]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461557891"                                                                                                                                                          
#>  [3] "162673491"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "3.79"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[103]]
#> $Table$Row[[103]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461558880"                                                                                                                                                          
#>  [3] "162674154"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] ""                                                                                                                                                                   
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[104]]
#> $Table$Row[[104]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461562991"                                                                                                                                                          
#>  [3] "162677073"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "Q01279"                                                                                                                                                             
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> [11] ""                                                                                                                                                                   
#> 
#> 
#> $Table$Row[[105]]
#> $Table$Row[[105]]$Cell
#>  [1] "1815786"                                                                                                                                        
#>  [2] "475982343"                                                                                                                                      
#>  [3] "166627448"                                                                                                                                      
#>  [4] "Unspecified"                                                                                                                                    
#>  [5] "Q01279"                                                                                                                                         
#>  [6] ""                                                                                                                                               
#>  [7] ""                                                                                                                                               
#>  [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR 19Del/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#>  [9] "Other"                                                                                                                                          
#> [10] "35178175"                                                                                                                                       
#> [11] ""                                                                                                                                               
#> 
#> 
#> $Table$Row[[106]]
#> $Table$Row[[106]]$Cell
#>  [1] "1815820"                                                                                                                                        
#>  [2] "475982343"                                                                                                                                      
#>  [3] "166627448"                                                                                                                                      
#>  [4] "Unspecified"                                                                                                                                    
#>  [5] "Q01279"                                                                                                                                         
#>  [6] ""                                                                                                                                               
#>  [7] ""                                                                                                                                               
#>  [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR L858R/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#>  [9] "Other"                                                                                                                                          
#> [10] "35178175"                                                                                                                                       
#> [11] ""                                                                                                                                               
#> 
#> 
#> $Table$Row[[107]]
#> $Table$Row[[107]]$Cell
#>  [1] "1862914"                                                                                                                                                                                                                             
#>  [2] "482063640"                                                                                                                                                                                                                           
#>  [3] "155431347"                                                                                                                                                                                                                           
#>  [4] "Active"                                                                                                                                                                                                                              
#>  [5] "Q01279"                                                                                                                                                                                                                              
#>  [6] ""                                                                                                                                                                                                                                    
#>  [7] ""                                                                                                                                                                                                                                    
#>  [8] "Invivo inhibition of EGFR phosphorylation in nude mouse implanted with mouse BaF3 cells harboring EGFR del18/T790M/C797S triple mutant at 20 mg/kg, po administered as single dose and measured upto 24 hrs by Western blot analysis"
#>  [9] "Other"                                                                                                                                                                                                                               
#> [10] "35810715"                                                                                                                                                                                                                            
#> [11] ""                                                                                                                                                                                                                                    
#> 
#> 
#> $Table$Row[[108]]
#> $Table$Row[[108]]$Cell
#>  [1] "1896806"                                                                                                                                           
#>  [2] "482061797"                                                                                                                                         
#>  [3] "166176964"                                                                                                                                         
#>  [4] "Unspecified"                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                            
#>  [6] ""                                                                                                                                                  
#>  [7] ""                                                                                                                                                  
#>  [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#>  [9] "Other"                                                                                                                                             
#> [10] "36384036"                                                                                                                                          
#> [11] ""                                                                                                                                                  
#> 
#> 
#> $Table$Row[[109]]
#> $Table$Row[[109]]$Cell
#>  [1] "1896806"                                                                                                                                           
#>  [2] "482062269"                                                                                                                                         
#>  [3] "168280117"                                                                                                                                         
#>  [4] "Unspecified"                                                                                                                                       
#>  [5] "Q01279"                                                                                                                                            
#>  [6] ""                                                                                                                                                  
#>  [7] ""                                                                                                                                                  
#>  [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#>  [9] "Other"                                                                                                                                             
#> [10] "36384036"                                                                                                                                          
#> [11] ""
  • Pathways from Gene: Provides a list of pathways involving a specific gene. For example, for gene ID 13649:
result <- get_pug_rest(identifier = "13649", namespace = "geneid", domain = "gene", operation = "pwaccs", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Gene
#>   - Namespace: DomainSpecific
#>   - Operation: pwaccs
#>   - Identifier: 13649
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>                      Text
#> 1          PANTHER:P06664
#> 2     PathBank:SMP0120900
#> 3     PathBank:SMP0120901
#> 4  Reactome:R-MMU-1227986
#> 5  Reactome:R-MMU-1236394
#> 6  Reactome:R-MMU-1266738
#> 7   Reactome:R-MMU-157118
#> 8   Reactome:R-MMU-162582
#> 9   Reactome:R-MMU-177929
#> 10  Reactome:R-MMU-179812
#> 11  Reactome:R-MMU-180292
#> 12  Reactome:R-MMU-180336
#> 13  Reactome:R-MMU-182971
#> 14  Reactome:R-MMU-199991
#> 15  Reactome:R-MMU-212718
#> 16 Reactome:R-MMU-2179392
#> 17  Reactome:R-MMU-372790
#> 18  Reactome:R-MMU-373760
#> 19  Reactome:R-MMU-388396
#> 20  Reactome:R-MMU-416476
#> 21  Reactome:R-MMU-422475
#> 22  Reactome:R-MMU-445144
#> 23 Reactome:R-MMU-5653656
#> 24  Reactome:R-MMU-881907
#> 25 Reactome:R-MMU-8848021
#> 26 Reactome:R-MMU-8856825
#> 27 Reactome:R-MMU-8856828
#> 28 Reactome:R-MMU-8857538
#> 29 Reactome:R-MMU-8939211
#> 30 Reactome:R-MMU-9006927
#> 31 Reactome:R-MMU-9006931
#> 32 Reactome:R-MMU-9006934
#> 33 Reactome:R-MMU-9009391
#> 34 Reactome:R-MMU-9012852
#> 35 Reactome:R-MMU-9013507
#> 36 Reactome:R-MMU-9675108
#> 37    WikiPathways:WP1261
#> 38     WikiPathways:WP265
#> 39    WikiPathways:WP2841
#> 40     WikiPathways:WP339
#> 41    WikiPathways:WP3663
#> 42     WikiPathways:WP488
#> 43     WikiPathways:WP493
#> 44     WikiPathways:WP523
#> 45    WikiPathways:WP5242
#> 46     WikiPathways:WP572
#> 47      WikiPathways:WP85

These methods offer a comprehensive way to access and analyze gene-related data in PubChem, catering to various research needs in genetics and molecular biology.

3.5. Proteins

PubChem provides a versatile platform for accessing detailed protein data, essential for researchers in biochemistry and molecular biology. Here’s how you can utilize PUG REST for protein-related queries:

1. Protein Input Methods:

  • By Protein Accession: Use NCBI Protein accessions to access protein data. For example, to get a summary for protein accessions P00533 and P01422 in JSON format:
result <- get_pug_rest(identifier = "P00533,P01422", namespace = "accession", domain = "protein", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Protein
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: P00533,P01422
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $ProteinSummaries
#> $ProteinSummaries$ProteinSummary
#> $ProteinSummaries$ProteinSummary[[1]]
#> $ProteinSummaries$ProteinSummary[[1]]$ProteinAccession
#> [1] "P00533"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Name
#> [1] "Epidermal growth factor receptor"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Synonym
#> [1] "EC 2.7.10.1"                            
#> [2] "Proto-oncogene c-ErbB-1"                
#> [3] "Receptor tyrosine-protein kinase erbB-1"
#> 
#> 
#> $ProteinSummaries$ProteinSummary[[2]]
#> $ProteinSummaries$ProteinSummary[[2]]$ProteinAccession
#> [1] "P01422"
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$Name
#> [1] "Short neurotoxin 2"
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$TaxonomyID
#> [1] 96794
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$Taxonomy
#> [1] "Naja annulifera (banded Egyptian cobra)"
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$Synonym
#> [1] "Toxin CM-14"  "Toxin V-N-I2"

By Protein Synonym: Access protein data using synonyms or identifiers from external sources. For example, using a ChEMBL ID:

result <- get_pug_rest(identifier = "ChEMBL:CHEMBL203", namespace = "synonym", domain = "protein", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Protein
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: ChEMBL:CHEMBL203
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $ProteinSummaries
#> $ProteinSummaries$ProteinSummary
#> $ProteinSummaries$ProteinSummary[[1]]
#> $ProteinSummaries$ProteinSummary[[1]]$ProteinAccession
#> [1] "P00533"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Name
#> [1] "Epidermal growth factor receptor"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Synonym
#> [1] "EC 2.7.10.1"                            
#> [2] "Proto-oncogene c-ErbB-1"                
#> [3] "Receptor tyrosine-protein kinase erbB-1"

2. Available Protein Data:

  • Protein Summary: Returns a summary including ProteinAccession, Name, TaxonomyID, and Synonyms. For example:
result <- get_pug_rest(identifier = "P00533,P01422", namespace = "accession", domain = "protein", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Protein
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: P00533,P01422
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $ProteinSummaries
#> $ProteinSummaries$ProteinSummary
#> $ProteinSummaries$ProteinSummary[[1]]
#> $ProteinSummaries$ProteinSummary[[1]]$ProteinAccession
#> [1] "P00533"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Name
#> [1] "Epidermal growth factor receptor"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> $ProteinSummaries$ProteinSummary[[1]]$Synonym
#> [1] "EC 2.7.10.1"                            
#> [2] "Proto-oncogene c-ErbB-1"                
#> [3] "Receptor tyrosine-protein kinase erbB-1"
#> 
#> 
#> $ProteinSummaries$ProteinSummary[[2]]
#> $ProteinSummaries$ProteinSummary[[2]]$ProteinAccession
#> [1] "P01422"
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$Name
#> [1] "Short neurotoxin 2"
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$TaxonomyID
#> [1] 96794
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$Taxonomy
#> [1] "Naja annulifera (banded Egyptian cobra)"
#> 
#> $ProteinSummaries$ProteinSummary[[2]]$Synonym
#> [1] "Toxin CM-14"  "Toxin V-N-I2"

Assays from Protein: Retrieves a list of AIDs tested against a specific protein. For example, for protein accession P00533:

result <- get_pug_rest(identifier = "P00533", namespace = "accession", domain = "protein", operation = "aids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Protein
#>   - Namespace: DomainSpecific
#>   - Operation: aids
#>   - Identifier: P00533
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>         Text
#> 1       1433
#> 2       1726
#> 3       1727
#> 4       1729
#> 5       1731
#> 6       1742
#> 7       1982
#> 8       3364
#> 9       3365
#> 10      7884
#> 11      7888
#> 12      7890
#> 13      7899
#> 14      7901
#> 15      7903
#> 16      7907
#> 17      7909
#> 18      7910
#> 19      7911
#> 20      8066
#> 21      8069
#> 22      8070
#> 23      8076
#> 24      8077
#> 25      8621
#> 26     32370
#> 27     51584
#> 28     66431
#> 29     66435
#> 30     66436
#> 31     66437
#> 32     66442
#> 33     66443
#> 34     66444
#> 35     66445
#> 36     66446
#> 37     66447
#> 38     66448
#> 39     66449
#> 40     66450
#> 41     66451
#> 42     66452
#> 43     66453
#> 44     66454
#> 45     66455
#> 46     66456
#> 47     66457
#> 48     66458
#> 49     66459
#> 50     66460
#> 51     66595
#> 52     66596
#> 53     66597
#> 54     66598
#> 55     66599
#> 56     66600
#> 57     66601
#> 58     66602
#> 59     66603
#> 60     66604
#> 61     66605
#> 62     66606
#> 63     66607
#> 64     66608
#> 65     66609
#> 66     66610
#> 67     66611
#> 68     66612
#> 69     66613
#> 70     66614
#> 71     66615
#> 72     66618
#> 73     66619
#> 74     66620
#> 75     66621
#> 76     66622
#> 77     66623
#> 78     66624
#> 79     66625
#> 80     66626
#> 81     66627
#> 82     66628
#> 83     66629
#> 84     66630
#> 85     66631
#> 86     67273
#> 87     67274
#> 88     67275
#> 89     67276
#> 90     67277
#> 91     67278
#> 92     67279
#> 93     67280
#> 94     67281
#> 95     67282
#> 96     67283
#> 97     67284
#> 98     67285
#> 99     67286
#> 100    67287
#> 101    67288
#> 102    67289
#> 103    67290
#> 104    67291
#> 105    67292
#> 106    67293
#> 107    67944
#> 108    67945
#> 109    67946
#> 110    67947
#> 111    67948
#> 112    67949
#> 113    67950
#> 114    67951
#> 115    67952
#> 116    67953
#> 117    67954
#> 118    67958
#> 119    67959
#> 120    67960
#> 121    67961
#> 122    67962
#> 123    67972
#> 124    67973
#> 125    68085
#> 126    68086
#> 127    68087
#> 128    68088
#> 129    68089
#> 130    68090
#> 131    68091
#> 132    68092
#> 133    68093
#> 134    68094
#> 135    69398
#> 136    69399
#> 137    69400
#> 138    69401
#> 139    69402
#> 140    69403
#> 141    69404
#> 142    69405
#> 143    69406
#> 144    69407
#> 145    69408
#> 146    69409
#> 147    69410
#> 148    69411
#> 149    69412
#> 150    69413
#> 151    69414
#> 152    69415
#> 153    69416
#> 154    69417
#> 155    69418
#> 156    69419
#> 157    69420
#> 158    69421
#> 159    69422
#> 160    69423
#> 161    69424
#> 162    69425
#> 163    69426
#> 164    69427
#> 165    69428
#> 166    69429
#> 167    69430
#> 168    69431
#> 169    69432
#> 170    69433
#> 171    69434
#> 172    69435
#> 173    69549
#> 174    69550
#> 175    69551
#> 176    69552
#> 177    69553
#> 178    69554
#> 179    69555
#> 180    69556
#> 181    69557
#> 182    69558
#> 183    69559
#> 184    69560
#> 185    69561
#> 186    69562
#> 187    69563
#> 188    69564
#> 189    69565
#> 190    69566
#> 191    69567
#> 192    69568
#> 193    69569
#> 194    69570
#> 195    69571
#> 196    69572
#> 197    69573
#> 198    69574
#> 199    69575
#> 200    69576
#> 201    69577
#> 202    69578
#> 203    69579
#> 204    69580
#> 205    69581
#> 206    69707
#> 207    69708
#> 208    69709
#> 209    69710
#> 210    69711
#> 211    69718
#> 212    69719
#> 213    69720
#> 214    69725
#> 215    69726
#> 216    69731
#> 217    69732
#> 218    69733
#> 219    69734
#> 220    69735
#> 221    69739
#> 222    69740
#> 223    69741
#> 224    69742
#> 225    69874
#> 226    69875
#> 227    69876
#> 228    69877
#> 229    69878
#> 230    69879
#> 231    69880
#> 232    69881
#> 233    69882
#> 234    69883
#> 235    69884
#> 236    69885
#> 237    69886
#> 238    69887
#> 239    69889
#> 240    69890
#> 241    69891
#> 242    69892
#> 243    69893
#> 244    69894
#> 245    69895
#> 246    69896
#> 247    69897
#> 248    69898
#> 249    69899
#> 250    69900
#> 251    69901
#> 252    69902
#> 253    69903
#> 254    69908
#> 255    69909
#> 256    69910
#> 257    69911
#> 258    69912
#> 259    69913
#> 260    69914
#> 261    69915
#> 262    70039
#> 263    70041
#> 264    70042
#> 265    70043
#> 266    70044
#> 267    70045
#> 268    70046
#> 269    70047
#> 270    70048
#> 271    70049
#> 272    70050
#> 273    70051
#> 274    70052
#> 275    70053
#> 276    70054
#> 277    70055
#> 278    79545
#> 279    81334
#> 280    81335
#> 281    81336
#> 282    81560
#> 283    81561
#> 284    81562
#> 285    81563
#> 286    81564
#> 287    81565
#> 288    81566
#> 289    81567
#> 290    81568
#> 291    81569
#> 292    81570
#> 293    81571
#> 294    81572
#> 295    81573
#> 296    81578
#> 297    84823
#> 298    85137
#> 299    85139
#> 300    89322
#> 301    89323
#> 302    89324
#> 303    89325
#> 304    89326
#> 305    92132
#> 306    96371
#> 307   102177
#> 308   102607
#> 309   162571
#> 310   164333
#> 311   205012
#> 312   205013
#> 313   215071
#> 314   219670
#> 315   224428
#> 316   224429
#> 317   226585
#> 318   227709
#> 319   235147
#> 320   235148
#> 321   240913
#> 322   240965
#> 323   241077
#> 324   241116
#> 325   241169
#> 326   241170
#> 327   241239
#> 328   241262
#> 329   241284
#> 330   241322
#> 331   241388
#> 332   241432
#> 333   241490
#> 334   241671
#> 335   241732
#> 336   241764
#> 337   241818
#> 338   241895
#> 339   241905
#> 340   241976
#> 341   242087
#> 342   242149
#> 343   242190
#> 344   242228
#> 345   242288
#> 346   242302
#> 347   242324
#> 348   242350
#> 349   242351
#> 350   242365
#> 351   242443
#> 352   242444
#> 353   242461
#> 354   242462
#> 355   242463
#> 356   242479
#> 357   242480
#> 358   242532
#> 359   242548
#> 360   243906
#> 361   243910
#> 362   243912
#> 363   244014
#> 364   244180
#> 365   244206
#> 366   248902
#> 367   248903
#> 368   248969
#> 369   254692
#> 370   254694
#> 371   254806
#> 372   254912
#> 373   254936
#> 374   254942
#> 375   255760
#> 376   256664
#> 377   256710
#> 378   257345
#> 379   257490
#> 380   258034
#> 381   258035
#> 382   258758
#> 383   258769
#> 384   258770
#> 385   258771
#> 386   258772
#> 387   258924
#> 388   258925
#> 389   258926
#> 390   259740
#> 391   259773
#> 392   259777
#> 393   259781
#> 394   259786
#> 395   259787
#> 396   259788
#> 397   259789
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#> 411   263473
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#> 414   263613
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#> 1031  637121
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#> 1039  639687
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#> 1042  642302
#> 1043  642483
#> 1044  642760
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#> 1100  662479
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#> 1199  689668
#> 1200  689678
#> 1201  690171
#> 1202  690206
#> 1203  691095
#> 1204  692840
#> 1205  694020
#> 1206  695967
#> 1207  696622
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#> 1209  697382
#> 1210  701047
#> 1211  705003
#> 1212  708790
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#> 1225  708978
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#> 1227  708984
#> 1228  709746
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#> 1246  715336
#> 1247  718823
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#> 1249  719231
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#> 1251  719885
#> 1252  719886
#> 1253  719889
#> 1254  719892
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#> 1256  720122
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#> 1260  723353
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#> 1272  729977
#> 1273  730005
#> 1274  731106
#> 1275  731916
#> 1276  732198
#> 1277  734141
#> 1278  734221
#> 1279  734224
#> 1280  734773
#> 1281  735315
#> 1282  735372
#> 1283  737513
#> 1284  737514
#> 1285  737515
#> 1286  737516
#> 1287  737517
#> 1288  738834
#> 1289  738835
#> 1290  738836
#> 1291  738837
#> 1292  739385
#> 1293  739427
#> 1294  739428
#> 1295  739429
#> 1296  739430
#> 1297  739685
#> 1298  739688
#> 1299  739690
#> 1300  739692
#> 1301  739693
#> 1302  739789
#> 1303  740396
#> 1304  740397
#> 1305  740935
#> 1306  740936
#> 1307  741245
#> 1308  741246
#> 1309  741247
#> 1310  741248
#> 1311  741249
#> 1312  743668
#> 1313  743671
#> 1314  745320
#> 1315  745352
#> 1316  746532
#> 1317  748064
#> 1318  748065
#> 1319  748066
#> 1320  748067
#> 1321  748068
#> 1322  748069
#> 1323  748091
#> 1324  748093
#> 1325  748094
#> 1326  748799
#> 1327  748805
#> 1328  749335
#> 1329  749394
#> 1330  749763
#> 1331  750072
#> 1332  752152
#> 1333  752176
#> 1334  752702
#> 1335  753284
#> 1336  755962
#> 1337  757290
#> 1338  757291
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#> 1340  757293
#> 1341  757294
#> 1342  757674
#> 1343  758024
#> 1344  760331
#> 1345  760332
#> 1346  761265
#> 1347  761587
#> 1348  761588
#> 1349  761589
#> 1350  761591
#> 1351  761601
#> 1352  761602
#> 1353  761603
#> 1354  764900
#> 1355  764901
#> 1356  764902
#> 1357  764903
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#> 1359  764905
#> 1360  764906
#> 1361  764907
#> 1362  764908
#> 1363  764909
#> 1364  764910
#> 1365  764911
#> 1366  764912
#> 1367  764925
#> 1368  764926
#> 1369  764927
#> 1370  764928
#> 1371  766544
#> 1372  766550
#> 1373  766931
#> 1374  767006
#> 1375  767092
#> 1376  768502
#> 1377  769201
#> 1378  769202
#> 1379  769206
#> 1380  769207
#> 1381  769368
#> 1382  770078
#> 1383  770081
#> 1384  770082
#> 1385  770083
#> 1386  770096
#> 1387  770439
#> 1388  770794
#> 1389  771338
#> 1390  771341
#> 1391  771342
#> 1392  771343
#> 1393  771344
#> 1394  771345
#> 1395  771346
#> 1396  774898
#> 1397  775221
#> 1398  775356
#> 1399  775615
#> 1400  775616
#> 1401  775619
#> 1402  775622
#> 1403  775623
#> 1404  775624
#> 1405  775625
#> 1406  776746
#> 1407  776778
#> 1408  777290
#> 1409  777398
#> 1410  777419
#> 1411  777420
#> 1412  777421
#> 1413  777422
#> 1414  777423
#> 1415  777424
#> 1416  778801
#> 1417  778844
#> 1418  779874
#> 1419  780347
#> 1420  780820
#> 1421 1053577
#> 1422 1053592
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#> 1453 1059193
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#> 1455 1060491
#> 1456 1061308
#> 1457 1061337
#> 1458 1061603
#> 1459 1062001
#> 1460 1062002
#> 1461 1062003
#> 1462 1064886
#> 1463 1066961
#> 1464 1067113
#> 1465 1068982
#> 1466 1068983
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#> 1468 1073264
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#> 1470 1075262
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#> 1475 1078355
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#> 1479 1078637
#> 1480 1078746
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#> 1482 1078973
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#> 1484 1079144
#> 1485 1079192
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#> 1487 1079363
#> 1488 1079750
#> 1489 1093388
#> 1490 1106449
#> 1491 1117570
#> 1492 1117574
#> 1493 1117575
#> 1494 1117576
#> 1495 1117578
#> 1496 1117804
#> 1497 1117806
#> 1498 1119051
#> 1499 1119724
#> 1500 1119822
#> 1501 1119823
#> 1502 1119827
#> 1503 1119828
#> 1504 1119829
#> 1505 1119830
#> 1506 1119835
#> 1507 1119836
#> 1508 1119837
#> 1509 1119838
#> 1510 1119839
#> 1511 1119840
#> 1512 1119841
#> 1513 1119842
#> 1514 1119844
#> 1515 1119845
#> 1516 1119846
#> 1517 1120079
#> 1518 1120256
#> 1519 1120257
#> 1520 1120258
#> 1521 1120259
#> 1522 1120260
#> 1523 1120261
#> 1524 1120262
#> 1525 1120322
#> 1526 1120783
#> 1527 1126274
#> 1528 1127829
#> 1529 1128564
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#> 1531 1128568
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#> 1533 1128570
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#> 1541 1128932
#> 1542 1128944
#> 1543 1128950
#> 1544 1128951
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#> 1547 1129568
#> 1548 1129569
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#> 1555 1137579
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#> 1559 1137600
#> 1560 1137607
#> 1561 1138452
#> 1562 1138453
#> 1563 1139063
#> 1564 1140573
#> 1565 1142096
#> 1566 1142097
#> 1567 1142420
#> 1568 1142994
#> 1569 1155021
#> 1570 1155097
#> 1571 1155100
#> 1572 1155502
#> 1573 1155508
#> 1574 1156999
#> 1575 1157406
#> 1576 1157567
#> 1577 1158369
#> 1578 1160535
#> 1579 1160536
#> 1580 1162094
#> 1581 1163157
#> 1582 1163158
#> 1583 1163159
#> 1584 1163160
#> 1585 1163161
#> 1586 1163162
#> 1587 1163163
#> 1588 1163187
#> 1589 1163188
#> 1590 1163220
#> 1591 1163221
#> 1592 1163222
#> 1593 1163223
#> 1594 1163224
#> 1595 1163225
#> 1596 1163289
#> 1597 1163503
#> 1598 1164107
#> 1599 1165336
#> 1600 1167082
#> 1601 1167101
#> 1602 1167102
#> 1603 1167103
#> 1604 1167665
#> 1605 1167806
#> 1606 1168535
#> 1607 1168539
#> 1608 1168541
#> 1609 1168542
#> 1610 1168545
#> 1611 1168547
#> 1612 1168548
#> 1613 1168554
#> 1614 1169271
#> 1615 1170394
#> 1616 1170824
#> 1617 1170825
#> 1618 1170826
#> 1619 1170838
#> 1620 1170839
#> 1621 1170850
#> 1622 1170851
#> 1623 1171419
#> 1624 1171420
#> 1625 1172278
#> 1626 1172507
#> 1627 1173104
#> 1628 1173170
#> 1629 1173888
#> 1630 1173894
#> 1631 1173900
#> 1632 1174299
#> 1633 1174871
#> 1634 1175324
#> 1635 1175520
#> 1636 1176840
#> 1637 1177759
#> 1638 1178238
#> 1639 1178239
#> 1640 1178687
#> 1641 1179013
#> 1642 1179600
#> 1643 1181816
#> 1644 1182667
#> 1645 1182830
#> 1646 1184140
#> 1647 1184492
#> 1648 1186391
#> 1649 1186630
#> 1650 1187672
#> 1651 1189770
#> 1652 1189786
#> 1653 1190102
#> 1654 1190117
#> 1655 1190132
#> 1656 1190997
#> 1657 1191001
#> 1658 1191167
#> 1659 1192060
#> 1660 1192061
#> 1661 1192062
#> 1662 1192063
#> 1663 1192065
#> 1664 1193682
#> 1665 1193684
#> 1666 1193956
#> 1667 1195283
#> 1668 1198818
#> 1669 1201366
#> 1670 1201367
#> 1671 1201368
#> 1672 1201369
#> 1673 1201370
#> 1674 1201886
#> 1675 1201887
#> 1676 1202434
#> 1677 1204628
#> 1678 1204629
#> 1679 1204630
#> 1680 1205021
#> 1681 1205971
#> 1682 1206239
#> 1683 1223918
#> 1684 1224256
#> 1685 1226561
#> 1686 1226614
#> 1687 1230130
#> 1688 1234624
#> 1689 1234984
#> 1690 1235505
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#> 1692 1240683
#> 1693 1241286
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#> 1700 1241297
#> 1701 1241298
#> 1702 1241299
#> 1703 1241300
#> 1704 1242283
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#> 1706 1242285
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#> 1708 1242287
#> 1709 1243173
#> 1710 1243176
#> 1711 1243996
#> 1712 1243997
#> 1713 1244850
#> 1714 1244851
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#> 1716 1244853
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#> 1719 1244856
#> 1720 1247594
#> 1721 1247624
#> 1722 1247695
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#> 1724 1247697
#> 1725 1247698
#> 1726 1247699
#> 1727 1247700
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#> 1729 1247702
#> 1730 1247703
#> 1731 1247704
#> 1732 1250263
#> 1733 1250365
#> 1734 1250380
#> 1735 1250405
#> 1736 1250406
#> 1737 1250407
#> 1738 1250408
#> 1739 1250409
#> 1740 1250410
#> 1741 1250411
#> 1742 1250748
#> 1743 1251091
#> 1744 1251459
#> 1745 1251460
#> 1746 1251475
#> 1747 1251476
#> 1748 1252466
#> 1749 1252467
#> 1750 1252717
#> 1751 1253271
#> 1752 1253398
#> 1753 1253399
#> 1754 1253719
#> 1755 1254370
#> 1756 1255209
#> 1757 1255210
#> 1758 1255211
#> 1759 1255233
#> 1760 1255234
#> 1761 1255250
#> 1762 1255251
#> 1763 1256452
#> 1764 1261426
#> 1765 1261427
#> 1766 1261447
#> 1767 1261455
#> 1768 1261456
#> 1769 1261461
#> 1770 1262476
#> 1771 1263409
#> 1772 1263411
#> 1773 1263969
#> 1774 1263972
#> 1775 1263984
#> 1776 1263987
#> 1777 1264286
#> 1778 1264287
#> 1779 1264288
#> 1780 1264289
#> 1781 1264290
#> 1782 1264291
#> 1783 1264567
#> 1784 1264572
#> 1785 1264814
#> 1786 1266267
#> 1787 1266268
#> 1788 1266550
#> 1789 1267818
#> 1790 1268284
#> 1791 1268676
#> 1792 1268756
#> 1793 1269775
#> 1794 1269991
#> 1795 1270174
#> 1796 1270377
#> 1797 1270378
#> 1798 1270379
#> 1799 1270380
#> 1800 1270381
#> 1801 1270382
#> 1802 1270384
#> 1803 1270385
#> 1804 1270386
#> 1805 1270387
#> 1806 1270388
#> 1807 1270393
#> 1808 1270394
#> 1809 1270398
#> 1810 1270399
#> 1811 1270400
#> 1812 1270401
#> 1813 1270402
#> 1814 1270403
#> 1815 1270404
#> 1816 1270405
#> 1817 1272593
#> 1818 1273072
#> 1819 1273653
#> 1820 1273654
#> 1821 1273663
#> 1822 1274037
#> 1823 1274046
#> 1824 1274047
#> 1825 1274048
#> 1826 1274049
#> 1827 1274115
#> 1828 1274116
#> 1829 1274117
#> 1830 1274118
#> 1831 1274119
#> 1832 1274360
#> 1833 1274365
#> 1834 1274919
#> 1835 1275676
#> 1836 1276507
#> 1837 1277862
#> 1838 1278231
#> 1839 1278392
#> 1840 1278393
#> 1841 1278394
#> 1842 1278400
#> 1843 1278401
#> 1844 1279048
#> 1845 1279101
#> 1846 1279299
#> 1847 1279301
#> 1848 1280769
#> 1849 1283722
#> 1850 1283723
#> 1851 1283724
#> 1852 1283725
#> 1853 1283726
#> 1854 1283992
#> 1855 1283993
#> 1856 1284867
#> 1857 1284943
#> 1858 1284944
#> 1859 1285190
#> 1860 1285291
#> 1861 1286788
#> 1862 1286789
#> 1863 1286791
#> 1864 1286793
#> 1865 1286794
#> 1866 1287299
#> 1867 1287300
#> 1868 1288051
#> 1869 1289534
#> 1870 1289535
#> 1871 1289536
#> 1872 1289537
#> 1873 1289538
#> 1874 1289541
#> 1875 1289542
#> 1876 1289543
#> 1877 1289544
#> 1878 1289545
#> 1879 1289546
#> 1880 1289550
#> 1881 1289551
#> 1882 1289554
#> 1883 1289555
#> 1884 1289557
#> 1885 1289558
#> 1886 1289559
#> 1887 1289561
#> 1888 1290653
#> 1889 1290958
#> 1890 1291005
#> 1891 1291016
#> 1892 1291323
#> 1893 1291324
#> 1894 1291325
#> 1895 1291326
#> 1896 1291327
#> 1897 1291328
#> 1898 1291329
#> 1899 1291330
#> 1900 1291332
#> 1901 1291334
#> 1902 1291335
#> 1903 1291336
#> 1904 1291347
#> 1905 1291348
#> 1906 1291349
#> 1907 1291350
#> 1908 1291351
#> 1909 1291354
#> 1910 1293803
#> 1911 1294530
#> 1912 1295944
#> 1913 1295947
#> 1914 1296983
#> 1915 1297808
#> 1916 1297809
#> 1917 1298012
#> 1918 1298088
#> 1919 1298203
#> 1920 1298204
#> 1921 1298217
#> 1922 1298487
#> 1923 1298660
#> 1924 1298661
#> 1925 1298663
#> 1926 1298664
#> 1927 1298665
#> 1928 1298673
#> 1929 1298674
#> 1930 1298675
#> 1931 1298676
#> 1932 1298677
#> 1933 1300486
#> 1934 1301213
#> 1935 1301217
#> 1936 1301348
#> 1937 1301349
#> 1938 1301350
#> 1939 1301362
#> 1940 1301717
#> 1941 1301793
#> 1942 1301821
#> 1943 1301832
#> 1944 1303327
#> 1945 1303331
#> 1946 1303332
#> 1947 1303333
#> 1948 1303334
#> 1949 1303336
#> 1950 1303337
#> 1951 1303338
#> 1952 1303339
#> 1953 1303342
#> 1954 1303499
#> 1955 1303500
#> 1956 1305066
#> 1957 1305352
#> 1958 1305355
#> 1959 1305356
#> 1960 1305357
#> 1961 1305360
#> 1962 1305361
#> 1963 1305373
#> 1964 1305808
#> 1965 1306574
#> 1966 1306576
#> 1967 1306577
#> 1968 1306578
#> 1969 1306579
#> 1970 1306580
#> 1971 1306581
#> 1972 1306585
#> 1973 1306586
#> 1974 1306587
#> 1975 1306588
#> 1976 1307364
#> 1977 1307365
#> 1978 1307366
#> 1979 1307368
#> 1980 1307369
#> 1981 1308939
#> 1982 1308940
#> 1983 1308941
#> 1984 1308942
#> 1985 1309512
#> 1986 1309513
#> 1987 1309514
#> 1988 1309518
#> 1989 1309519
#> 1990 1310977
#> 1991 1312467
#> 1992 1312557
#> 1993 1312558
#> 1994 1312564
#> 1995 1312565
#> 1996 1312566
#> 1997 1313622
#> 1998 1315424
#> 1999 1315978
#> 2000 1315982
#> 2001 1315985
#> 2002 1315986
#> 2003 1315987
#> 2004 1317489
#> 2005 1317873
#> 2006 1317881
#> 2007 1317922
#> 2008 1317923
#> 2009 1319175
#> 2010 1321087
#> 2011 1321088
#> 2012 1321089
#> 2013 1321090
#> 2014 1321091
#> 2015 1321092
#> 2016 1321093
#> 2017 1321095
#> 2018 1321096
#> 2019 1321097
#> 2020 1321098
#> 2021 1321151
#> 2022 1321152
#> 2023 1321153
#> 2024 1321154
#> 2025 1321923
#> 2026 1321924
#> 2027 1321926
#> 2028 1325432
#> 2029 1326940
#> 2030 1330640
#> 2031 1330728
#> 2032 1330842
#> 2033 1330923
#> 2034 1330924
#> 2035 1330928
#> 2036 1330931
#> 2037 1330933
#> 2038 1330935
#> 2039 1330937
#> 2040 1330939
#> 2041 1330949
#> 2042 1330950
#> 2043 1330966
#> 2044 1330967
#> 2045 1335027
#> 2046 1335805
#> 2047 1336032
#> 2048 1337176
#> 2049 1337730
#> 2050 1341596
#> 2051 1341617
#> 2052 1341622
#> 2053 1341624
#> 2054 1341757
#> 2055 1341758
#> 2056 1341763
#> 2057 1341764
#> 2058 1341765
#> 2059 1341766
#> 2060 1341767
#> 2061 1342328
#> 2062 1342636
#> 2063 1345502
#> 2064 1348155
#> 2065 1350803
#> 2066 1350804
#> 2067 1350805
#> 2068 1350806
#> 2069 1350814
#> 2070 1350815
#> 2071 1350816
#> 2072 1350817
#> 2073 1350820
#> 2074 1350821
#> 2075 1350822
#> 2076 1350853
#> 2077 1350854
#> 2078 1350855
#> 2079 1350856
#> 2080 1350857
#> 2081 1350858
#> 2082 1350859
#> 2083 1350860
#> 2084 1350861
#> 2085 1350862
#> 2086 1350863
#> 2087 1350864
#> 2088 1350897
#> 2089 1352745
#> 2090 1352750
#> 2091 1353459
#> 2092 1353460
#> 2093 1353461
#> 2094 1353462
#> 2095 1353463
#> 2096 1353464
#> 2097 1353465
#> 2098 1353466
#> 2099 1353467
#> 2100 1353468
#> 2101 1353469
#> 2102 1353470
#> 2103 1353471
#> 2104 1353472
#> 2105 1353476
#> 2106 1353477
#> 2107 1353478
#> 2108 1353479
#> 2109 1353480
#> 2110 1353481
#> 2111 1353482
#> 2112 1357746
#> 2113 1357755
#> 2114 1358748
#> 2115 1358811
#> 2116 1359368
#> 2117 1359369
#> 2118 1359374
#> 2119 1359375
#> 2120 1359376
#> 2121 1359377
#> 2122 1359917
#> 2123 1359922
#> 2124 1359923
#> 2125 1360607
#> 2126 1360965
#> 2127 1361678
#> 2128 1361679
#> 2129 1361680
#> 2130 1361681
#> 2131 1361682
#> 2132 1361683
#> 2133 1361863
#> 2134 1361864
#> 2135 1361865
#> 2136 1361866
#> 2137 1361867
#> 2138 1361868
#> 2139 1361869
#> 2140 1361871
#> 2141 1361872
#> 2142 1361873
#> 2143 1361874
#> 2144 1364047
#> 2145 1364403
#> 2146 1364452
#> 2147 1364453
#> 2148 1364458
#> 2149 1364459
#> 2150 1364462
#> 2151 1364463
#> 2152 1364466
#> 2153 1364537
#> 2154 1364538
#> 2155 1364539
#> 2156 1364541
#> 2157 1364542
#> 2158 1364543
#> 2159 1364545
#> 2160 1364548
#> 2161 1365191
#> 2162 1365564
#> 2163 1365565
#> 2164 1365566
#> 2165 1365567
#> 2166 1365568
#> 2167 1365569
#> 2168 1365570
#> 2169 1365571
#> 2170 1365572
#> 2171 1365573
#> 2172 1365574
#> 2173 1365575
#> 2174 1365576
#> 2175 1365577
#> 2176 1365578
#> 2177 1365583
#> 2178 1365584
#> 2179 1365585
#> 2180 1365586
#> 2181 1365587
#> 2182 1365748
#> 2183 1366001
#> 2184 1367262
#> 2185 1367529
#> 2186 1367530
#> 2187 1368035
#> 2188 1368036
#> 2189 1370352
#> 2190 1370933
#> 2191 1371602
#> 2192 1371603
#> 2193 1371604
#> 2194 1371605
#> 2195 1371606
#> 2196 1371607
#> 2197 1371608
#> 2198 1371609
#> 2199 1371610
#> 2200 1371611
#> 2201 1371612
#> 2202 1371613
#> 2203 1372110
#> 2204 1372112
#> 2205 1372113
#> 2206 1372114
#> 2207 1372115
#> 2208 1372117
#> 2209 1372118
#> 2210 1372400
#> 2211 1373080
#> 2212 1373081
#> 2213 1374818
#> 2214 1375525
#> 2215 1376029
#> 2216 1376035
#> 2217 1376036
#> 2218 1376515
#> 2219 1376516
#> 2220 1376517
#> 2221 1376518
#> 2222 1376519
#> 2223 1378273
#> 2224 1378274
#> 2225 1378275
#> 2226 1378276
#> 2227 1378277
#> 2228 1378278
#> 2229 1378279
#> 2230 1378280
#> 2231 1378281
#> 2232 1378282
#> 2233 1378283
#> 2234 1378287
#> 2235 1378288
#> 2236 1378289
#> 2237 1378290
#> 2238 1378291
#> 2239 1378292
#> 2240 1378293
#> 2241 1379773
#> 2242 1381595
#> 2243 1381744
#> 2244 1381770
#> 2245 1382532
#> 2246 1382533
#> 2247 1382534
#> 2248 1382535
#> 2249 1382536
#> 2250 1382537
#> 2251 1382538
#> 2252 1389856
#> 2253 1389857
#> 2254 1389858
#> 2255 1389969
#> 2256 1389971
#> 2257 1390633
#> 2258 1390635
#> 2259 1390636
#> 2260 1390638
#> 2261 1390894
#> 2262 1391281
#> 2263 1391283
#> 2264 1391284
#> 2265 1391286
#> 2266 1391841
#> 2267 1393181
#> 2268 1393599
#> 2269 1394199
#> 2270 1394200
#> 2271 1394201
#> 2272 1394202
#> 2273 1394203
#> 2274 1394204
#> 2275 1394205
#> 2276 1394206
#> 2277 1394207
#> 2278 1394208
#> 2279 1394209
#> 2280 1394210
#> 2281 1394679
#> 2282 1394683
#> 2283 1394726
#> 2284 1394727
#> 2285 1394812
#> 2286 1395241
#> 2287 1396416
#> 2288 1396417
#> 2289 1396513
#> 2290 1396514
#> 2291 1396811
#> 2292 1396844
#> 2293 1397231
#> 2294 1398876
#> 2295 1399364
#> 2296 1399807
#> 2297 1401884
#> 2298 1401963
#> 2299 1402422
#> 2300 1402423
#> 2301 1402424
#> 2302 1402504
#> 2303 1402505
#> 2304 1402506
#> 2305 1402960
#> 2306 1402961
#> 2307 1402962
#> 2308 1402963
#> 2309 1403293
#> 2310 1403294
#> 2311 1403917
#> 2312 1404100
#> 2313 1404619
#> 2314 1404759
#> 2315 1404897
#> 2316 1404960
#> 2317 1404962
#> 2318 1404963
#> 2319 1404964
#> 2320 1404965
#> 2321 1404966
#> 2322 1404967
#> 2323 1404968
#> 2324 1404974
#> 2325 1404975
#> 2326 1404976
#> 2327 1404977
#> 2328 1404978
#> 2329 1404979
#> 2330 1404980
#> 2331 1404981
#> 2332 1406661
#> 2333 1407099
#> 2334 1407100
#> 2335 1407101
#> 2336 1407105
#> 2337 1407106
#> 2338 1409093
#> 2339 1411545
#> 2340 1411546
#> 2341 1411549
#> 2342 1411550
#> 2343 1411551
#> 2344 1411556
#> 2345 1411557
#> 2346 1411558
#> 2347 1412316
#> 2348 1412317
#> 2349 1412321
#> 2350 1412322
#> 2351 1412323
#> 2352 1412324
#> 2353 1412325
#> 2354 1412326
#> 2355 1412463
#> 2356 1412703
#> 2357 1412708
#> 2358 1412846
#> 2359 1415023
#> 2360 1417363
#> 2361 1417834
#> 2362 1417835
#> 2363 1417836
#> 2364 1417837
#> 2365 1417838
#> 2366 1417839
#> 2367 1417840
#> 2368 1417841
#> 2369 1417842
#> 2370 1417843
#> 2371 1417844
#> 2372 1417845
#> 2373 1418418
#> 2374 1418419
#> 2375 1418420
#> 2376 1419163
#> 2377 1419930
#> 2378 1419931
#> 2379 1420632
#> 2380 1420633
#> 2381 1420634
#> 2382 1420635
#> 2383 1420636
#> 2384 1420640
#> 2385 1420671
#> 2386 1420674
#> 2387 1420676
#> 2388 1420678
#> 2389 1420679
#> 2390 1420680
#> 2391 1420681
#> 2392 1420682
#> 2393 1420683
#> 2394 1420684
#> 2395 1420685
#> 2396 1420686
#> 2397 1421134
#> 2398 1421264
#> 2399 1421409
#> 2400 1421410
#> 2401 1422234
#> 2402 1423307
#> 2403 1423308
#> 2404 1423311
#> 2405 1423312
#> 2406 1423824
#> 2407 1423825
#> 2408 1423826
#> 2409 1423828
#> 2410 1423829
#> 2411 1423830
#> 2412 1423831
#> 2413 1424192
#> 2414 1424193
#> 2415 1424200
#> 2416 1424201
#> 2417 1424202
#> 2418 1424203
#> 2419 1424204
#> 2420 1424205
#> 2421 1424206
#> 2422 1424207
#> 2423 1424261
#> 2424 1424262
#> 2425 1424361
#> 2426 1424363
#> 2427 1424364
#> 2428 1424369
#> 2429 1424371
#> 2430 1424372
#> 2431 1424373
#> 2432 1424398
#> 2433 1424983
#> 2434 1426855
#> 2435 1426964
#> 2436 1428029
#> 2437 1428030
#> 2438 1428362
#> 2439 1428884
#> 2440 1430980
#> 2441 1431174
#> 2442 1431285
#> 2443 1432775
#> 2444 1432776
#> 2445 1432777
#> 2446 1432797
#> 2447 1432798
#> 2448 1432799
#> 2449 1432800
#> 2450 1434201
#> 2451 1434568
#> 2452 1434569
#> 2453 1434579
#> 2454 1434580
#> 2455 1434581
#> 2456 1434582
#> 2457 1435450
#> 2458 1435625
#> 2459 1435626
#> 2460 1435627
#> 2461 1435628
#> 2462 1435629
#> 2463 1435630
#> 2464 1436457
#> 2465 1436879
#> 2466 1438343
#> 2467 1439619
#> 2468 1439620
#> 2469 1439621
#> 2470 1439622
#> 2471 1439623
#> 2472 1439624
#> 2473 1439625
#> 2474 1439629
#> 2475 1439630
#> 2476 1439631
#> 2477 1439632
#> 2478 1439753
#> 2479 1440116
#> 2480 1440316
#> 2481 1440730
#> 2482 1441910
#> 2483 1441911
#> 2484 1441912
#> 2485 1441913
#> 2486 1441914
#> 2487 1441917
#> 2488 1441922
#> 2489 1441923
#> 2490 1441924
#> 2491 1441925
#> 2492 1441929
#> 2493 1441930
#> 2494 1441931
#> 2495 1441932
#> 2496 1441937
#> 2497 1441938
#> 2498 1441939
#> 2499 1441940
#> 2500 1441941
#> 2501 1441942
#> 2502 1441944
#> 2503 1441945
#> 2504 1441946
#> 2505 1441947
#> 2506 1441948
#> 2507 1441949
#> 2508 1441950
#> 2509 1441951
#> 2510 1441952
#> 2511 1442426
#> 2512 1442427
#> 2513 1442428
#> 2514 1443455
#> 2515 1443465
#> 2516 1443477
#> 2517 1443538
#> 2518 1444111
#> 2519 1444155
#> 2520 1444158
#> 2521 1444159
#> 2522 1444160
#> 2523 1444161
#> 2524 1445468
#> 2525 1445469
#> 2526 1445470
#> 2527 1445471
#> 2528 1445472
#> 2529 1445473
#> 2530 1445474
#> 2531 1445479
#> 2532 1445480
#> 2533 1445481
#> 2534 1446437
#> 2535 1446714
#> 2536 1446715
#> 2537 1450098
#> 2538 1450405
#> 2539 1450412
#> 2540 1450709
#> 2541 1450710
#> 2542 1450767
#> 2543 1450768
#> 2544 1450769
#> 2545 1452382
#> 2546 1452454
#> 2547 1455679
#> 2548 1458976
#> 2549 1458977
#> 2550 1458978
#> 2551 1459020
#> 2552 1461120
#> 2553 1461121
#> 2554 1461122
#> 2555 1461123
#> 2556 1461124
#> 2557 1461125
#> 2558 1461126
#> 2559 1461127
#> 2560 1461128
#> 2561 1461129
#> 2562 1461130
#> 2563 1461131
#> 2564 1461711
#> 2565 1461712
#> 2566 1461714
#> 2567 1461715
#> 2568 1461716
#> 2569 1461717
#> 2570 1461718
#> 2571 1461719
#> 2572 1461720
#> 2573 1461721
#> 2574 1461722
#> 2575 1462163
#> 2576 1463353
#> 2577 1463973
#> 2578 1463975
#> 2579 1464302
#> 2580 1464456
#> 2581 1466303
#> 2582 1466304
#> 2583 1466329
#> 2584 1466854
#> 2585 1468807
#> 2586 1469701
#> 2587 1469776
#> 2588 1469777
#> 2589 1469778
#> 2590 1469779
#> 2591 1469890
#> 2592 1470056
#> 2593 1470057
#> 2594 1470058
#> 2595 1470059
#> 2596 1470060
#> 2597 1470061
#> 2598 1470062
#> 2599 1470063
#> 2600 1470064
#> 2601 1470065
#> 2602 1470066
#> 2603 1470067
#> 2604 1470863
#> 2605 1470864
#> 2606 1470865
#> 2607 1470939
#> 2608 1470940
#> 2609 1470960
#> 2610 1471073
#> 2611 1471074
#> 2612 1471075
#> 2613 1471076
#> 2614 1471077
#> 2615 1471079
#> 2616 1474494
#> 2617 1475828
#> 2618 1478764
#> 2619 1478910
#> 2620 1478911
#> 2621 1481308
#> 2622 1481309
#> 2623 1481310
#> 2624 1481312
#> 2625 1481313
#> 2626 1481314
#> 2627 1481316
#> 2628 1481317
#> 2629 1481318
#> 2630 1481319
#> 2631 1481320
#> 2632 1481321
#> 2633 1481322
#> 2634 1481323
#> 2635 1481324
#> 2636 1481325
#> 2637 1481326
#> 2638 1481327
#> 2639 1481328
#> 2640 1481329
#> 2641 1481330
#> 2642 1481331
#> 2643 1481340
#> 2644 1481341
#> 2645 1481350
#> 2646 1481351
#> 2647 1481353
#> 2648 1481354
#> 2649 1481355
#> 2650 1481356
#> 2651 1481357
#> 2652 1481358
#> 2653 1481361
#> 2654 1481362
#> 2655 1481363
#> 2656 1481364
#> 2657 1481365
#> 2658 1481366
#> 2659 1481367
#> 2660 1481368
#> 2661 1481369
#> 2662 1481370
#> 2663 1481371
#> 2664 1481372
#> 2665 1481373
#> 2666 1481374
#> 2667 1481375
#> 2668 1481376
#> 2669 1481377
#> 2670 1481378
#> 2671 1481379
#> 2672 1481380
#> 2673 1481381
#> 2674 1481382
#> 2675 1481383
#> 2676 1481384
#> 2677 1481385
#> 2678 1481386
#> 2679 1481427
#> 2680 1481428
#> 2681 1481429
#> 2682 1481430
#> 2683 1481431
#> 2684 1481432
#> 2685 1483363
#> 2686 1483364
#> 2687 1483365
#> 2688 1483366
#> 2689 1483367
#> 2690 1483368
#> 2691 1483369
#> 2692 1483370
#> 2693 1483375
#> 2694 1483376
#> 2695 1483377
#> 2696 1483378
#> 2697 1483379
#> 2698 1483380
#> 2699 1483385
#> 2700 1483386
#> 2701 1483387
#> 2702 1483388
#> 2703 1483389
#> 2704 1483390
#> 2705 1483391
#> 2706 1483410
#> 2707 1483411
#> 2708 1483412
#> 2709 1484432
#> 2710 1484433
#> 2711 1484434
#> 2712 1484894
#> 2713 1484895
#> 2714 1485537
#> 2715 1488002
#> 2716 1488003
#> 2717 1488004
#> 2718 1488207
#> 2719 1488208
#> 2720 1488209
#> 2721 1488516
#> 2722 1488737
#> 2723 1488746
#> 2724 1490106
#> 2725 1490107
#> 2726 1491837
#> 2727 1491838
#> 2728 1492056
#> 2729 1492163
#> 2730 1492192
#> 2731 1492283
#> 2732 1492390
#> 2733 1492412
#> 2734 1492507
#> 2735 1492556
#> 2736 1492632
#> 2737 1492672
#> 2738 1492990
#> 2739 1493616
#> 2740 1494799
#> 2741 1497678
#> 2742 1497679
#> 2743 1497680
#> 2744 1497681
#> 2745 1497682
#> 2746 1497683
#> 2747 1497684
#> 2748 1497691
#> 2749 1497692
#> 2750 1497693
#> 2751 1497694
#> 2752 1498599
#> 2753 1498600
#> 2754 1498606
#> 2755 1498607
#> 2756 1498608
#> 2757 1498609
#> 2758 1498610
#> 2759 1498611
#> 2760 1499230
#> 2761 1499231
#> 2762 1499233
#> 2763 1499598
#> 2764 1499599
#> 2765 1499600
#> 2766 1499601
#> 2767 1499602
#> 2768 1499603
#> 2769 1499604
#> 2770 1499605
#> 2771 1499606
#> 2772 1500166
#> 2773 1500431
#> 2774 1502391
#> 2775 1503435
#> 2776 1503436
#> 2777 1504166
#> 2778 1504753
#> 2779 1507120
#> 2780 1507441
#> 2781 1507444
#> 2782 1507448
#> 2783 1507462
#> 2784 1508705
#> 2785 1508706
#> 2786 1508844
#> 2787 1509627
#> 2788 1510874
#> 2789 1511366
#> 2790 1511394
#> 2791 1511583
#> 2792 1511584
#> 2793 1511585
#> 2794 1511586
#> 2795 1511587
#> 2796 1511588
#> 2797 1511589
#> 2798 1511590
#> 2799 1511591
#> 2800 1511592
#> 2801 1511593
#> 2802 1511594
#> 2803 1513293
#> 2804 1516620
#> 2805 1516673
#> 2806 1517030
#> 2807 1517249
#> 2808 1518420
#> 2809 1518421
#> 2810 1518422
#> 2811 1518423
#> 2812 1518424
#> 2813 1519080
#> 2814 1519106
#> 2815 1519413
#> 2816 1519414
#> 2817 1519441
#> 2818 1519442
#> 2819 1520225
#> 2820 1525532
#> 2821 1527516
#> 2822 1527518
#> 2823 1528993
#> 2824 1529017
#> 2825 1529900
#> 2826 1530946
#> 2827 1531306
#> 2828 1531670
#> 2829 1532891
#> 2830 1532893
#> 2831 1533594
#> 2832 1534219
#> 2833 1535422
#> 2834 1535423
#> 2835 1535424
#> 2836 1535425
#> 2837 1535426
#> 2838 1535427
#> 2839 1535438
#> 2840 1535442
#> 2841 1535504
#> 2842 1536118
#> 2843 1536504
#> 2844 1536505
#> 2845 1536506
#> 2846 1536507
#> 2847 1536508
#> 2848 1536509
#> 2849 1536510
#> 2850 1536511
#> 2851 1536512
#> 2852 1536513
#> 2853 1536514
#> 2854 1536515
#> 2855 1538060
#> 2856 1538061
#> 2857 1538062
#> 2858 1538063
#> 2859 1538064
#> 2860 1538771
#> 2861 1539887
#> 2862 1539888
#> 2863 1539889
#> 2864 1539890
#> 2865 1539891
#> 2866 1540476
#> 2867 1541723
#> 2868 1542170
#> 2869 1542831
#> 2870 1542926
#> 2871 1543469
#> 2872 1543716
#> 2873 1544356
#> 2874 1544357
#> 2875 1544720
#> 2876 1544721
#> 2877 1544759
#> 2878 1545164
#> 2879 1545376
#> 2880 1545466
#> 2881 1545469
#> 2882 1545470
#> 2883 1545471
#> 2884 1545472
#> 2885 1545473
#> 2886 1545474
#> 2887 1545475
#> 2888 1545476
#> 2889 1545477
#> 2890 1545478
#> 2891 1545480
#> 2892 1545481
#> 2893 1545484
#> 2894 1545485
#> 2895 1545486
#> 2896 1545489
#> 2897 1545497
#> 2898 1545522
#> 2899 1548404
#> 2900 1548406
#> 2901 1549279
#> 2902 1549564
#> 2903 1550199
#> 2904 1550200
#> 2905 1550517
#> 2906 1550976
#> 2907 1551638
#> 2908 1551665
#> 2909 1551765
#> 2910 1551768
#> 2911 1551769
#> 2912 1552893
#> 2913 1553448
#> 2914 1554252
#> 2915 1554253
#> 2916 1554254
#> 2917 1554255
#> 2918 1554256
#> 2919 1554763
#> 2920 1555636
#> 2921 1555842
#> 2922 1555843
#> 2923 1556671
#> 2924 1557565
#> 2925 1558400
#> 2926 1559935
#> 2927 1560155
#> 2928 1560156
#> 2929 1560157
#> 2930 1560158
#> 2931 1560159
#> 2932 1560160
#> 2933 1560161
#> 2934 1560162
#> 2935 1560163
#> 2936 1560164
#> 2937 1560165
#> 2938 1560166
#> 2939 1560826
#> 2940 1560842
#> 2941 1561646
#> 2942 1561647
#> 2943 1562643
#> 2944 1562644
#> 2945 1562645
#> 2946 1562646
#> 2947 1562647
#> 2948 1562648
#> 2949 1562649
#> 2950 1562650
#> 2951 1562651
#> 2952 1562652
#> 2953 1562653
#> 2954 1562654
#> 2955 1562655
#> 2956 1563732
#> 2957 1563733
#> 2958 1564219
#> 2959 1564228
#> 2960 1564389
#> 2961 1565409
#> 2962 1565421
#> 2963 1565422
#> 2964 1565423
#> 2965 1565424
#> 2966 1565425
#> 2967 1565431
#> 2968 1565432
#> 2969 1565433
#> 2970 1565434
#> 2971 1565435
#> 2972 1565436
#> 2973 1565438
#> 2974 1567753
#> 2975 1567754
#> 2976 1567755
#> 2977 1567756
#> 2978 1567757
#> 2979 1567758
#> 2980 1567759
#> 2981 1567760
#> 2982 1567761
#> 2983 1567762
#> 2984 1567763
#> 2985 1567764
#> 2986 1568440
#> 2987 1572261
#> 2988 1572263
#> 2989 1572264
#> 2990 1572286
#> 2991 1572652
#> 2992 1572752
#> 2993 1573270
#> 2994 1573285
#> 2995 1573349
#> 2996 1574235
#> 2997 1574928
#> 2998 1574929
#> 2999 1574930
#> 3000 1576796
#> 3001 1576797
#> 3002 1576798
#> 3003 1576799
#> 3004 1576941
#> 3005 1576959
#> 3006 1578256
#> 3007 1578257
#> 3008 1578258
#> 3009 1578326
#> 3010 1579440
#> 3011 1580125
#> 3012 1580126
#> 3013 1580127
#> 3014 1580189
#> 3015 1580190
#> 3016 1580191
#> 3017 1580192
#> 3018 1580193
#> 3019 1580194
#> 3020 1580220
#> 3021 1580221
#> 3022 1580222
#> 3023 1580223
#> 3024 1580224
#> 3025 1580528
#> 3026 1580946
#> 3027 1580947
#> 3028 1580948
#> 3029 1580949
#> 3030 1580950
#> 3031 1582348
#> 3032 1582365
#> 3033 1582366
#> 3034 1582367
#> 3035 1582368
#> 3036 1582370
#> 3037 1582371
#> 3038 1582372
#> 3039 1582373
#> 3040 1582374
#> 3041 1582375
#> 3042 1582376
#> 3043 1582377
#> 3044 1582378
#> 3045 1582379
#> 3046 1582380
#> 3047 1582381
#> 3048 1582382
#> 3049 1582383
#> 3050 1582384
#> 3051 1582385
#> 3052 1582386
#> 3053 1582387
#> 3054 1582388
#> 3055 1582389
#> 3056 1582390
#> 3057 1582391
#> 3058 1582392
#> 3059 1582393
#> 3060 1582394
#> 3061 1582395
#> 3062 1582398
#> 3063 1582399
#> 3064 1582400
#> 3065 1582401
#> 3066 1582402
#> 3067 1582403
#> 3068 1582404
#> 3069 1582405
#> 3070 1582406
#> 3071 1582407
#> 3072 1582408
#> 3073 1582409
#> 3074 1582410
#> 3075 1582411
#> 3076 1582412
#> 3077 1582413
#> 3078 1582414
#> 3079 1582415
#> 3080 1582416
#> 3081 1582417
#> 3082 1582418
#> 3083 1582419
#> 3084 1582420
#> 3085 1582421
#> 3086 1582422
#> 3087 1582423
#> 3088 1582424
#> 3089 1582425
#> 3090 1582426
#> 3091 1582427
#> 3092 1582428
#> 3093 1582429
#> 3094 1582430
#> 3095 1582431
#> 3096 1582432
#> 3097 1582433
#> 3098 1582434
#> 3099 1582435
#> 3100 1582436
#> 3101 1582437
#> 3102 1582438
#> 3103 1582439
#> 3104 1582440
#> 3105 1582442
#> 3106 1582443
#> 3107 1583836
#> 3108 1583837
#> 3109 1583838
#> 3110 1583839
#> 3111 1583840
#> 3112 1583841
#> 3113 1583844
#> 3114 1583845
#> 3115 1583851
#> 3116 1583854
#> 3117 1583855
#> 3118 1583862
#> 3119 1583863
#> 3120 1583865
#> 3121 1583867
#> 3122 1583869
#> 3123 1583870
#> 3124 1584016
#> 3125 1584017
#> 3126 1584018
#> 3127 1584019
#> 3128 1584020
#> 3129 1584021
#> 3130 1584022
#> 3131 1584023
#> 3132 1584024
#> 3133 1584025
#> 3134 1584026
#> 3135 1584027
#> 3136 1584395
#> 3137 1585296
#> 3138 1585297
#> 3139 1585298
#> 3140 1585300
#> 3141 1585301
#> 3142 1585302
#> 3143 1585303
#> 3144 1585919
#> 3145 1585920
#> 3146 1585964
#> 3147 1585965
#> 3148 1585966
#> 3149 1585970
#> 3150 1585971
#> 3151 1585972
#> 3152 1585980
#> 3153 1585981
#> 3154 1585982
#> 3155 1586668
#> 3156 1586911
#> 3157 1587023
#> 3158 1587025
#> 3159 1588684
#> 3160 1588685
#> 3161 1588959
#> 3162 1589886
#> 3163 1589887
#> 3164 1589904
#> 3165 1589905
#> 3166 1589906
#> 3167 1589907
#> 3168 1589908
#> 3169 1589909
#> 3170 1589910
#> 3171 1589911
#> 3172 1589912
#> 3173 1589913
#> 3174 1589914
#> 3175 1589920
#> 3176 1589921
#> 3177 1589922
#> 3178 1589923
#> 3179 1589924
#> 3180 1589925
#> 3181 1590557
#> 3182 1590558
#> 3183 1590559
#> 3184 1590560
#> 3185 1590561
#> 3186 1590562
#> 3187 1590563
#> 3188 1590564
#> 3189 1590565
#> 3190 1590566
#> 3191 1590567
#> 3192 1590568
#> 3193 1591034
#> 3194 1591035
#> 3195 1591036
#> 3196 1591037
#> 3197 1591038
#> 3198 1591039
#> 3199 1591040
#> 3200 1591041
#> 3201 1591042
#> 3202 1591043
#> 3203 1591044
#> 3204 1591045
#> 3205 1591631
#> 3206 1592583
#> 3207 1592584
#> 3208 1592585
#> 3209 1592586
#> 3210 1592587
#> 3211 1592588
#> 3212 1592589
#> 3213 1592590
#> 3214 1592591
#> 3215 1592592
#> 3216 1592593
#> 3217 1592594
#> 3218 1594502
#> 3219 1594503
#> 3220 1595473
#> 3221 1595474
#> 3222 1595475
#> 3223 1595476
#> 3224 1595477
#> 3225 1595478
#> 3226 1595485
#> 3227 1595486
#> 3228 1595487
#> 3229 1595488
#> 3230 1595615
#> 3231 1595618
#> 3232 1595620
#> 3233 1595637
#> 3234 1595638
#> 3235 1595639
#> 3236 1595644
#> 3237 1595651
#> 3238 1596990
#> 3239 1597221
#> 3240 1598163
#> 3241 1599509
#> 3242 1599511
#> 3243 1599794
#> 3244 1599795
#> 3245 1599836
#> 3246 1599837
#> 3247 1599838
#> 3248 1599843
#> 3249 1599844
#> 3250 1599893
#> 3251 1599932
#> 3252 1599941
#> 3253 1599942
#> 3254 1599945
#> 3255 1599946
#> 3256 1599950
#> 3257 1599951
#> 3258 1599952
#> 3259 1600531
#> 3260 1600532
#> 3261 1600798
#> 3262 1601052
#> 3263 1601320
#> 3264 1602519
#> 3265 1602520
#> 3266 1602521
#> 3267 1602522
#> 3268 1602523
#> 3269 1602524
#> 3270 1602525
#> 3271 1602526
#> 3272 1602527
#> 3273 1603711
#> 3274 1606161
#> 3275 1607642
#> 3276 1607643
#> 3277 1608248
#> 3278 1608655
#> 3279 1608656
#> 3280 1608657
#> 3281 1608658
#> 3282 1609522
#> 3283 1610896
#> 3284 1610897
#> 3285 1610943
#> 3286 1610967
#> 3287 1610968
#> 3288 1610969
#> 3289 1611097
#> 3290 1611104
#> 3291 1611560
#> 3292 1611561
#> 3293 1611562
#> 3294 1611563
#> 3295 1611564
#> 3296 1611565
#> 3297 1611566
#> 3298 1611567
#> 3299 1611568
#> 3300 1612545
#> 3301 1612546
#> 3302 1612890
#> 3303 1612891
#> 3304 1612896
#> 3305 1612929
#> 3306 1612959
#> 3307 1612989
#> 3308 1613109
#> 3309 1614789
#> 3310 1614797
#> 3311 1615345
#> 3312 1615387
#> 3313 1616553
#> 3314 1616555
#> 3315 1616556
#> 3316 1616559
#> 3317 1616561
#> 3318 1616564
#> 3319 1616575
#> 3320 1616576
#> 3321 1616577
#> 3322 1616578
#> 3323 1616579
#> 3324 1616580
#> 3325 1616581
#> 3326 1616582
#> 3327 1616583
#> 3328 1616584
#> 3329 1616585
#> 3330 1616586
#> 3331 1616601
#> 3332 1616603
#> 3333 1616948
#> 3334 1617466
#> 3335 1617467
#> 3336 1617468
#> 3337 1617954
#> 3338 1617955
#> 3339 1617956
#> 3340 1617957
#> 3341 1617959
#> 3342 1617960
#> 3343 1617961
#> 3344 1617975
#> 3345 1617981
#> 3346 1617982
#> 3347 1617983
#> 3348 1618015
#> 3349 1618026
#> 3350 1620788
#> 3351 1625022
#> 3352 1625319
#> 3353 1625320
#> 3354 1625325
#> 3355 1625327
#> 3356 1627085
#> 3357 1627086
#> 3358 1627091
#> 3359 1627092
#> 3360 1627104
#> 3361 1627105
#> 3362 1627106
#> 3363 1627692
#> 3364 1627748
#> 3365 1629483
#> 3366 1630435
#> 3367 1630436
#> 3368 1630438
#> 3369 1630439
#> 3370 1631222
#> 3371 1632290
#> 3372 1632301
#> 3373 1632327
#> 3374 1633243
#> 3375 1636724
#> 3376 1636808
#> 3377 1636809
#> 3378 1637072
#> 3379 1637540
#> 3380 1638787
#> 3381 1638788
#> 3382 1646570
#> 3383 1646613
#> 3384 1646614
#> 3385 1646615
#> 3386 1646616
#> 3387 1646617
#> 3388 1646945
#> 3389 1646966
#> 3390 1649859
#> 3391 1649860
#> 3392 1649861
#> 3393 1649862
#> 3394 1649863
#> 3395 1649864
#> 3396 1649865
#> 3397 1652200
#> 3398 1654042
#> 3399 1656256
#> 3400 1656714
#> 3401 1656715
#> 3402 1656985
#> 3403 1658303
#> 3404 1658308
#> 3405 1658309
#> 3406 1658312
#> 3407 1658313
#> 3408 1658315
#> 3409 1658316
#> 3410 1658317
#> 3411 1658318
#> 3412 1658319
#> 3413 1658320
#> 3414 1658321
#> 3415 1658322
#> 3416 1658323
#> 3417 1658324
#> 3418 1658325
#> 3419 1658326
#> 3420 1658327
#> 3421 1658328
#> 3422 1658329
#> 3423 1659246
#> 3424 1659784
#> 3425 1659786
#> 3426 1659955
#> 3427 1659956
#> 3428 1659957
#> 3429 1659958
#> 3430 1659959
#> 3431 1659960
#> 3432 1659961
#> 3433 1659962
#> 3434 1659963
#> 3435 1659964
#> 3436 1659965
#> 3437 1659966
#> 3438 1659967
#> 3439 1659968
#> 3440 1659972
#> 3441 1659973
#> 3442 1659974
#> 3443 1664188
#> 3444 1664192
#> 3445 1664193
#> 3446 1664194
#> 3447 1664195
#> 3448 1664196
#> 3449 1664199
#> 3450 1664200
#> 3451 1664394
#> 3452 1664395
#> 3453 1664396
#> 3454 1664397
#> 3455 1664425
#> 3456 1664426
#> 3457 1664427
#> 3458 1667574
#> 3459 1667575
#> 3460 1667592
#> 3461 1672580
#> 3462 1672723
#> 3463 1672724
#> 3464 1672938
#> 3465 1673088
#> 3466 1673305
#> 3467 1673312
#> 3468 1673827
#> 3469 1673834
#> 3470 1673934
#> 3471 1676511
#> 3472 1676512
#> 3473 1676513
#> 3474 1676514
#> 3475 1676515
#> 3476 1676680
#> 3477 1676868
#> 3478 1676869
#> 3479 1677821
#> 3480 1677853
#> 3481 1679034
#> 3482 1679045
#> 3483 1679757
#> 3484 1688918
#> 3485 1688919
#> 3486 1689697
#> 3487 1690317
#> 3488 1690728
#> 3489 1690736
#> 3490 1690737
#> 3491 1690738
#> 3492 1690739
#> 3493 1690740
#> 3494 1690741
#> 3495 1690742
#> 3496 1690743
#> 3497 1690744
#> 3498 1690749
#> 3499 1691109
#> 3500 1691110
#> 3501 1691112
#> 3502 1691113
#> 3503 1691116
#> 3504 1691117
#> 3505 1691118
#> 3506 1691119
#> 3507 1691120
#> 3508 1691121
#> 3509 1691122
#> 3510 1691125
#> 3511 1691126
#> 3512 1691127
#> 3513 1691128
#> 3514 1691129
#> 3515 1691130
#> 3516 1691131
#> 3517 1691132
#> 3518 1691133
#> 3519 1691134
#> 3520 1691135
#> 3521 1691136
#> 3522 1691137
#> 3523 1691139
#> 3524 1691140
#> 3525 1691141
#> 3526 1691142
#> 3527 1691143
#> 3528 1691144
#> 3529 1691145
#> 3530 1691384
#> 3531 1693246
#> 3532 1695555
#> 3533 1697063
#> 3534 1699720
#> 3535 1699735
#> 3536 1702613
#> 3537 1702614
#> 3538 1702615
#> 3539 1702616
#> 3540 1703381
#> 3541 1703398
#> 3542 1704357
#> 3543 1704927
#> 3544 1704928
#> 3545 1704929
#> 3546 1704930
#> 3547 1704931
#> 3548 1704939
#> 3549 1704940
#> 3550 1704941
#> 3551 1704942
#> 3552 1704943
#> 3553 1704944
#> 3554 1704945
#> 3555 1704946
#> 3556 1704947
#> 3557 1704948
#> 3558 1704949
#> 3559 1704950
#> 3560 1704951
#> 3561 1704952
#> 3562 1704953
#> 3563 1704954
#> 3564 1704955
#> 3565 1704956
#> 3566 1704957
#> 3567 1704960
#> 3568 1704961
#> 3569 1704962
#> 3570 1704963
#> 3571 1704964
#> 3572 1704965
#> 3573 1704966
#> 3574 1704967
#> 3575 1704968
#> 3576 1704969
#> 3577 1704970
#> 3578 1704971
#> 3579 1704972
#> 3580 1704973
#> 3581 1704974
#> 3582 1704975
#> 3583 1704976
#> 3584 1704977
#> 3585 1704978
#> 3586 1706939
#> 3587 1708147
#> 3588 1708236
#> 3589 1708237
#> 3590 1708238
#> 3591 1708302
#> 3592 1709289
#> 3593 1709292
#> 3594 1709313
#> 3595 1709314
#> 3596 1709316
#> 3597 1709459
#> 3598 1710199
#> 3599 1710850
#> 3600 1710851
#> 3601 1711467
#> 3602 1712123
#> 3603 1713436
#> 3604 1713454
#> 3605 1713455
#> 3606 1713456
#> 3607 1713467
#> 3608 1713705
#> 3609 1714838
#> 3610 1715121
#> 3611 1715371
#> 3612 1715723
#> 3613 1715787
#> 3614 1715788
#> 3615 1715789
#> 3616 1715791
#> 3617 1715796
#> 3618 1715979
#> 3619 1717446
#> 3620 1717447
#> 3621 1717448
#> 3622 1717449
#> 3623 1718804
#> 3624 1718805
#> 3625 1718891
#> 3626 1718992
#> 3627 1718993
#> 3628 1719557
#> 3629 1719558
#> 3630 1719559
#> 3631 1719560
#> 3632 1719561
#> 3633 1719562
#> 3634 1719563
#> 3635 1719564
#> 3636 1720107
#> 3637 1720112
#> 3638 1720507
#> 3639 1720509
#> 3640 1720514
#> 3641 1720530
#> 3642 1721874
#> 3643 1723351
#> 3644 1723352
#> 3645 1724039
#> 3646 1724046
#> 3647 1724051
#> 3648 1724473
#> 3649 1724474
#> 3650 1724534
#> 3651 1724535
#> 3652 1724536
#> 3653 1724541
#> 3654 1724542
#> 3655 1724543
#> 3656 1724890
#> 3657 1724891
#> 3658 1724899
#> 3659 1724914
#> 3660 1724922
#> 3661 1724925
#> 3662 1726708
#> 3663 1726709
#> 3664 1726716
#> 3665 1730437
#> 3666 1730445
#> 3667 1730446
#> 3668 1730447
#> 3669 1730448
#> 3670 1730449
#> 3671 1730450
#> 3672 1730451
#> 3673 1730452
#> 3674 1730458
#> 3675 1730459
#> 3676 1730460
#> 3677 1730461
#> 3678 1730462
#> 3679 1730463
#> 3680 1730464
#> 3681 1730858
#> 3682 1730859
#> 3683 1730860
#> 3684 1730865
#> 3685 1730866
#> 3686 1730883
#> 3687 1730885
#> 3688 1730886
#> 3689 1730888
#> 3690 1730889
#> 3691 1730891
#> 3692 1730892
#> 3693 1731395
#> 3694 1731397
#> 3695 1731979
#> 3696 1734767
#> 3697 1734769
#> 3698 1735358
#> 3699 1737847
#> 3700 1738031
#> 3701 1738032
#> 3702 1738033
#> 3703 1738568
#> 3704 1738669
#> 3705 1738670
#> 3706 1738671
#> 3707 1738675
#> 3708 1738676
#> 3709 1738683
#> 3710 1738684
#> 3711 1738685
#> 3712 1738686
#> 3713 1738687
#> 3714 1738688
#> 3715 1738689
#> 3716 1738690
#> 3717 1738691
#> 3718 1738692
#> 3719 1739679
#> 3720 1739959
#> 3721 1739960
#> 3722 1739964
#> 3723 1739965
#> 3724 1740136
#> 3725 1740137
#> 3726 1740138
#> 3727 1740139
#> 3728 1740140
#> 3729 1740141
#> 3730 1740143
#> 3731 1740144
#> 3732 1740145
#> 3733 1740146
#> 3734 1740147
#> 3735 1740149
#> 3736 1741603
#> 3737 1742783
#> 3738 1743535
#> 3739 1743741
#> 3740 1746461
#> 3741 1746462
#> 3742 1746463
#> 3743 1746464
#> 3744 1746465
#> 3745 1746466
#> 3746 1746467
#> 3747 1746468
#> 3748 1746469
#> 3749 1746470
#> 3750 1746471
#> 3751 1746472
#> 3752 1747049
#> 3753 1747050
#> 3754 1747051
#> 3755 1747052
#> 3756 1747053
#> 3757 1747054
#> 3758 1747055
#> 3759 1747056
#> 3760 1747057
#> 3761 1747058
#> 3762 1747059
#> 3763 1747060
#> 3764 1747475
#> 3765 1747476
#> 3766 1747477
#> 3767 1747478
#> 3768 1747479
#> 3769 1747480
#> 3770 1747481
#> 3771 1747482
#> 3772 1747483
#> 3773 1747484
#> 3774 1747485
#> 3775 1747486
#> 3776 1747905
#> 3777 1748066
#> 3778 1748067
#> 3779 1748068
#> 3780 1748069
#> 3781 1748070
#> 3782 1748071
#> 3783 1748072
#> 3784 1748073
#> 3785 1748074
#> 3786 1748075
#> 3787 1748076
#> 3788 1748077
#> 3789 1749383
#> 3790 1750396
#> 3791 1751280
#> 3792 1751281
#> 3793 1751473
#> 3794 1752176
#> 3795 1753429
#> 3796 1753430
#> 3797 1753431
#> 3798 1755834
#> 3799 1756967
#> 3800 1756968
#> 3801 1756972
#> 3802 1756991
#> 3803 1756992
#> 3804 1756993
#> 3805 1756994
#> 3806 1756995
#> 3807 1756996
#> 3808 1757018
#> 3809 1757235
#> 3810 1757237
#> 3811 1757409
#> 3812 1757439
#> 3813 1758203
#> 3814 1760291
#> 3815 1760294
#> 3816 1760612
#> 3817 1760613
#> 3818 1760614
#> 3819 1760615
#> 3820 1762240
#> 3821 1764517
#> 3822 1765422
#> 3823 1765423
#> 3824 1766922
#> 3825 1766923
#> 3826 1766924
#> 3827 1766925
#> 3828 1766926
#> 3829 1766927
#> 3830 1766928
#> 3831 1766929
#> 3832 1766930
#> 3833 1766931
#> 3834 1766932
#> 3835 1766933
#> 3836 1766934
#> 3837 1766936
#> 3838 1766937
#> 3839 1766938
#> 3840 1766939
#> 3841 1766940
#> 3842 1766949
#> 3843 1766950
#> 3844 1766951
#> 3845 1766952
#> 3846 1766953
#> 3847 1766954
#> 3848 1766955
#> 3849 1766957
#> 3850 1768123
#> 3851 1769046
#> 3852 1769053
#> 3853 1769056
#> 3854 1769799
#> 3855 1770181
#> 3856 1770182
#> 3857 1770183
#> 3858 1770184
#> 3859 1770185
#> 3860 1770186
#> 3861 1770187
#> 3862 1770188
#> 3863 1770189
#> 3864 1770190
#> 3865 1770191
#> 3866 1770192
#> 3867 1770193
#> 3868 1770194
#> 3869 1770240
#> 3870 1770241
#> 3871 1770245
#> 3872 1770246
#> 3873 1770247
#> 3874 1770248
#> 3875 1771671
#> 3876 1771672
#> 3877 1771673
#> 3878 1771674
#> 3879 1771675
#> 3880 1771676
#> 3881 1771694
#> 3882 1771695
#> 3883 1771696
#> 3884 1771697
#> 3885 1771698
#> 3886 1771699
#> 3887 1771700
#> 3888 1771701
#> 3889 1771702
#> 3890 1771703
#> 3891 1771720
#> 3892 1771721
#> 3893 1771722
#> 3894 1771723
#> 3895 1771724
#> 3896 1771729
#> 3897 1772706
#> 3898 1772707
#> 3899 1772708
#> 3900 1772709
#> 3901 1772744
#> 3902 1772745
#> 3903 1772778
#> 3904 1772779
#> 3905 1772780
#> 3906 1772900
#> 3907 1772909
#> 3908 1772920
#> 3909 1772921
#> 3910 1772922
#> 3911 1773379
#> 3912 1775724
#> 3913 1776223
#> 3914 1776225
#> 3915 1776908
#> 3916 1777020
#> 3917 1778613
#> 3918 1779644
#> 3919 1780856
#> 3920 1781602
#> 3921 1781999
#> 3922 1784108
#> 3923 1784184
#> 3924 1784553
#> 3925 1784556
#> 3926 1784557
#> 3927 1784562
#> 3928 1784591
#> 3929 1784593
#> 3930 1784612
#> 3931 1785056
#> 3932 1785942
#> 3933 1785943
#> 3934 1786376
#> 3935 1786832
#> 3936 1787124
#> 3937 1787306
#> 3938 1787623
#> 3939 1788980
#> 3940 1789257
#> 3941 1789668
#> 3942 1789731
#> 3943 1790049
#> 3944 1790164
#> 3945 1790165
#> 3946 1790166
#> 3947 1790167
#> 3948 1790168
#> 3949 1790482
#> 3950 1790553
#> 3951 1790653
#> 3952 1790985
#> 3953 1790986
#> 3954 1790987
#> 3955 1790988
#> 3956 1790989
#> 3957 1791476
#> 3958 1791587
#> 3959 1792259
#> 3960 1792260
#> 3961 1792261
#> 3962 1792262
#> 3963 1792263
#> 3964 1792264
#> 3965 1792265
#> 3966 1792266
#> 3967 1792267
#> 3968 1792268
#> 3969 1792269
#> 3970 1792659
#> 3971 1793069
#> 3972 1793363
#> 3973 1793654
#> 3974 1794053
#> 3975 1794054
#> 3976 1794055
#> 3977 1794056
#> 3978 1794057
#> 3979 1794058
#> 3980 1794059
#> 3981 1794060
#> 3982 1794061
#> 3983 1794062
#> 3984 1794063
#> 3985 1794064
#> 3986 1794473
#> 3987 1794553
#> 3988 1794871
#> 3989 1795051
#> 3990 1795071
#> 3991 1795072
#> 3992 1795073
#> 3993 1795123
#> 3994 1795309
#> 3995 1795419
#> 3996 1795424
#> 3997 1795439
#> 3998 1795457
#> 3999 1795505
#> 4000 1795513
#> 4001 1795518
#> 4002 1795540
#> 4003 1795546
#> 4004 1795547
#> 4005 1795551
#> 4006 1795552
#> 4007 1795555
#> 4008 1795556
#> 4009 1795558
#> 4010 1795584
#> 4011 1795588
#> 4012 1795591
#> 4013 1795628
#> 4014 1795632
#> 4015 1795635
#> 4016 1795638
#> 4017 1795646
#> 4018 1795660
#> 4019 1795681
#> 4020 1795684
#> 4021 1795688
#> 4022 1795704
#> 4023 1795705
#> 4024 1795712
#> 4025 1795741
#> 4026 1795746
#> 4027 1795747
#> 4028 1795752
#> 4029 1795753
#> 4030 1795774
#> 4031 1795775
#> 4032 1795856
#> 4033 1795889
#> 4034 1795895
#> 4035 1795900
#> 4036 1795920
#> 4037 1795974
#> 4038 1796250
#> 4039 1796430
#> 4040 1796550
#> 4041 1796605
#> 4042 1796863
#> 4043 1796887
#> 4044 1796911
#> 4045 1796957
#> 4046 1797176
#> 4047 1797252
#> 4048 1797253
#> 4049 1797254
#> 4050 1797255
#> 4051 1797499
#> 4052 1798057
#> 4053 1798058
#> 4054 1798059
#> 4055 1798060
#> 4056 1798141
#> 4057 1798142
#> 4058 1798244
#> 4059 1798381
#> 4060 1798403
#> 4061 1798470
#> 4062 1798474
#> 4063 1798578
#> 4064 1798633
#> 4065 1798634
#> 4066 1798858
#> 4067 1798859
#> 4068 1798869
#> 4069 1798897
#> 4070 1798900
#> 4071 1799141
#> 4072 1799178
#> 4073 1799243
#> 4074 1799574
#> 4075 1799615
#> 4076 1799617
#> 4077 1799625
#> 4078 1799771
#> 4079 1799815
#> 4080 1800017
#> 4081 1800264
#> 4082 1800296
#> 4083 1800438
#> 4084 1800686
#> 4085 1800785
#> 4086 1800803
#> 4087 1800956
#> 4088 1801080
#> 4089 1801412
#> 4090 1801434
#> 4091 1801474
#> 4092 1801647
#> 4093 1801868
#> 4094 1801874
#> 4095 1801898
#> 4096 1802136
#> 4097 1802137
#> 4098 1802325
#> 4099 1802525
#> 4100 1802578
#> 4101 1802918
#> 4102 1802919
#> 4103 1802936
#> 4104 1802974
#> 4105 1802992
#> 4106 1803023
#> 4107 1803024
#> 4108 1803025
#> 4109 1803088
#> 4110 1803154
#> 4111 1803180
#> 4112 1803181
#> 4113 1803203
#> 4114 1803274
#> 4115 1803310
#> 4116 1803399
#> 4117 1803412
#> 4118 1803805
#> 4119 1803853
#> 4120 1803858
#> 4121 1804000
#> 4122 1804197
#> 4123 1804293
#> 4124 1804325
#> 4125 1804410
#> 4126 1804433
#> 4127 1804859
#> 4128 1804965
#> 4129 1804972
#> 4130 1804977
#> 4131 1805069
#> 4132 1805145
#> 4133 1805273
#> 4134 1805304
#> 4135 1805507
#> 4136 1805558
#> 4137 1805668
#> 4138 1805683
#> 4139 1805847
#> 4140 1805904
#> 4141 1805911
#> 4142 1805923
#> 4143 1806019
#> 4144 1806100
#> 4145 1806101
#> 4146 1806114
#> 4147 1806351
#> 4148 1806356
#> 4149 1806384
#> 4150 1806436
#> 4151 1806437
#> 4152 1806453
#> 4153 1806454
#> 4154 1806503
#> 4155 1806542
#> 4156 1806553
#> 4157 1806554
#> 4158 1806579
#> 4159 1806610
#> 4160 1806667
#> 4161 1806668
#> 4162 1806769
#> 4163 1806801
#> 4164 1807691
#> 4165 1807692
#> 4166 1807693
#> 4167 1807694
#> 4168 1807698
#> 4169 1807699
#> 4170 1807700
#> 4171 1807880
#> 4172 1809035
#> 4173 1809036
#> 4174 1809037
#> 4175 1809038
#> 4176 1809051
#> 4177 1809346
#> 4178 1809347
#> 4179 1809348
#> 4180 1809353
#> 4181 1809354
#> 4182 1809355
#> 4183 1809356
#> 4184 1809435
#> 4185 1809462
#> 4186 1809464
#> 4187 1810735
#> 4188 1811625
#> 4189 1811626
#> 4190 1811627
#> 4191 1811628
#> 4192 1811975
#> 4193 1812027
#> 4194 1812036
#> 4195 1812038
#> 4196 1812799
#> 4197 1812800
#> 4198 1812801
#> 4199 1812802
#> 4200 1813292
#> 4201 1813864
#> 4202 1813866
#> 4203 1813869
#> 4204 1813879
#> 4205 1813976
#> 4206 1814379
#> 4207 1815232
#> 4208 1815785
#> 4209 1815787
#> 4210 1815789
#> 4211 1816270
#> 4212 1817355
#> 4213 1817356
#> 4214 1817358
#> 4215 1817360
#> 4216 1817364
#> 4217 1817366
#> 4218 1817367
#> 4219 1817369
#> 4220 1817372
#> 4221 1820084
#> 4222 1821869
#> 4223 1822764
#> 4224 1822769
#> 4225 1822806
#> 4226 1822807
#> 4227 1823020
#> 4228 1824039
#> 4229 1824040
#> 4230 1824041
#> 4231 1825949
#> 4232 1825950
#> 4233 1825951
#> 4234 1825968
#> 4235 1825969
#> 4236 1830144
#> 4237 1830145
#> 4238 1830146
#> 4239 1830557
#> 4240 1834113
#> 4241 1834646
#> 4242 1834755
#> 4243 1834949
#> 4244 1835706
#> 4245 1845273
#> 4246 1845392
#> 4247 1846706
#> 4248 1846709
#> 4249 1846710
#> 4250 1846711
#> 4251 1846712
#> 4252 1846713
#> 4253 1846715
#> 4254 1846717
#> 4255 1846721
#> 4256 1846723
#> 4257 1846724
#> 4258 1846730
#> 4259 1846731
#> 4260 1846734
#> 4261 1846747
#> 4262 1846777
#> 4263 1846789
#> 4264 1846790
#> 4265 1846838
#> 4266 1848430
#> 4267 1848536
#> 4268 1848537
#> 4269 1849135
#> 4270 1849136
#> 4271 1849655
#> 4272 1850190
#> 4273 1851522
#> 4274 1853203
#> 4275 1855210
#> 4276 1855624
#> 4277 1855769
#> 4278 1856438
#> 4279 1857167
#> 4280 1857195
#> 4281 1858633
#> 4282 1858635
#> 4283 1859058
#> 4284 1859065
#> 4285 1859066
#> 4286 1859161
#> 4287 1859426
#> 4288 1859429
#> 4289 1859430
#> 4290 1859431
#> 4291 1859432
#> 4292 1859433
#> 4293 1859434
#> 4294 1859435
#> 4295 1860200
#> 4296 1860386
#> 4297 1860451
#> 4298 1860733
#> 4299 1860734
#> 4300 1860735
#> 4301 1860736
#> 4302 1860737
#> 4303 1860738
#> 4304 1860739
#> 4305 1860740
#> 4306 1860741
#> 4307 1860742
#> 4308 1860743
#> 4309 1860769
#> 4310 1860770
#> 4311 1861560
#> 4312 1861561
#> 4313 1861562
#> 4314 1861565
#> 4315 1861566
#> 4316 1861567
#> 4317 1861568
#> 4318 1861569
#> 4319 1861570
#> 4320 1861607
#> 4321 1861611
#> 4322 1861965
#> 4323 1861966
#> 4324 1861967
#> 4325 1861968
#> 4326 1861969
#> 4327 1862859
#> 4328 1862860
#> 4329 1862861
#> 4330 1862936
#> 4331 1862937
#> 4332 1864438
#> 4333 1864595
#> 4334 1865358
#> 4335 1865359
#> 4336 1865379
#> 4337 1865380
#> 4338 1865381
#> 4339 1865382
#> 4340 1865403
#> 4341 1865404
#> 4342 1865633
#> 4343 1865634
#> 4344 1865635
#> 4345 1865636
#> 4346 1865637
#> 4347 1865638
#> 4348 1865645
#> 4349 1866055
#> 4350 1866989
#> 4351 1867134
#> 4352 1867135
#> 4353 1867136
#> 4354 1867137
#> 4355 1867185
#> 4356 1867186
#> 4357 1867213
#> 4358 1867214
#> 4359 1867215
#> 4360 1867476
#> 4361 1867477
#> 4362 1867478
#> 4363 1867479
#> 4364 1870642
#> 4365 1870643
#> 4366 1870651
#> 4367 1870653
#> 4368 1870654
#> 4369 1870656
#> 4370 1870657
#> 4371 1870658
#> 4372 1871558
#> 4373 1871559
#> 4374 1871560
#> 4375 1871564
#> 4376 1871566
#> 4377 1871567
#> 4378 1871569
#> 4379 1871573
#> 4380 1871580
#> 4381 1871582
#> 4382 1871584
#> 4383 1871588
#> 4384 1871593
#> 4385 1871597
#> 4386 1871599
#> 4387 1871600
#> 4388 1871765
#> 4389 1872757
#> 4390 1873620
#> 4391 1874024
#> 4392 1875934
#> 4393 1876161
#> 4394 1876269
#> 4395 1877817
#> 4396 1877822
#> 4397 1877823
#> 4398 1877824
#> 4399 1877909
#> 4400 1878118
#> 4401 1880122
#> 4402 1880123
#> 4403 1880124
#> 4404 1880126
#> 4405 1880128
#> 4406 1880129
#> 4407 1880130
#> 4408 1880132
#> 4409 1880138
#> 4410 1880140
#> 4411 1880576
#> 4412 1880577
#> 4413 1880578
#> 4414 1880579
#> 4415 1880580
#> 4416 1880581
#> 4417 1880582
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#> 4419 1880584
#> 4420 1880585
#> 4421 1880586
#> 4422 1880588
#> 4423 1880589
#> 4424 1880590
#> 4425 1880591
#> 4426 1880592
#> 4427 1880593
#> 4428 1880594
#> 4429 1880595
#> 4430 1880596
#> 4431 1880597
#> 4432 1880598
#> 4433 1880599
#> 4434 1880600
#> 4435 1880601
#> 4436 1880602
#> 4437 1880603
#> 4438 1880604
#> 4439 1880605
#> 4440 1880606
#> 4441 1880607
#> 4442 1880608
#> 4443 1880609
#> 4444 1880610
#> 4445 1880611
#> 4446 1880612
#> 4447 1880613
#> 4448 1880614
#> 4449 1880615
#> 4450 1880616
#> 4451 1880617
#> 4452 1880618
#> 4453 1880619
#> 4454 1880620
#> 4455 1880621
#> 4456 1880622
#> 4457 1880627
#> 4458 1880628
#> 4459 1881816
#> 4460 1881817
#> 4461 1881819
#> 4462 1881820
#> 4463 1881821
#> 4464 1881822
#> 4465 1881823
#> 4466 1881824
#> 4467 1882134
#> 4468 1882139
#> 4469 1882140
#> 4470 1882141
#> 4471 1882145
#> 4472 1882626
#> 4473 1882627
#> 4474 1882632
#> 4475 1882637
#> 4476 1882641
#> 4477 1882645
#> 4478 1882646
#> 4479 1882652
#> 4480 1882655
#> 4481 1882660
#> 4482 1882661
#> 4483 1883959
#> 4484 1884418
#> 4485 1884788
#> 4486 1884789
#> 4487 1884790
#> 4488 1884791
#> 4489 1885339
#> 4490 1885341
#> 4491 1885342
#> 4492 1885343
#> 4493 1885371
#> 4494 1885372
#> 4495 1885373
#> 4496 1885374
#> 4497 1885375
#> 4498 1885376
#> 4499 1885377
#> 4500 1885486
#> 4501 1886715
#> 4502 1887635
#> 4503 1887636
#> 4504 1887637
#> 4505 1887639
#> 4506 1887642
#> 4507 1887643
#> 4508 1887647
#> 4509 1887648
#> 4510 1887649
#> 4511 1887680
#> 4512 1888970
#> 4513 1889499
#> 4514 1890815
#> 4515 1890816
#> 4516 1891048
#> 4517 1891050
#> 4518 1891069
#> 4519 1891383
#> 4520 1893104
#> 4521 1893379
#> 4522 1894146
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#> 4524 1894149
#> 4525 1894151
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#> 4527 1894153
#> 4528 1894155
#> 4529 1894156
#> 4530 1894157
#> 4531 1894161
#> 4532 1894164
#> 4533 1894624
#> 4534 1894678
#> 4535 1895668
#> 4536 1895673
#> 4537 1896769
#> 4538 1896770
#> 4539 1896771
#> 4540 1896772
#> 4541 1896773
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#> 4543 1896775
#> 4544 1896782
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#> 4546 1896785
#> 4547 1896786
#> 4548 1896787
#> 4549 1896788
#> 4550 1896791
#> 4551 1898317
#> 4552 1898661
#> 4553 1898662
#> 4554 1898665
#> 4555 1898666
#> 4556 1898674
#> 4557 1899709
#> 4558 1901540
#> 4559 1904029
#> 4560 1904122
#> 4561 1904299
#> 4562 1904300
#> 4563 1904301
#> 4564 1904302
#> 4565 1904305
#> 4566 1904306
#> 4567 1904309
#> 4568 1904310
#> 4569 1904311
#> 4570 1904318
#> 4571 1904319
#> 4572 1904320
#> 4573 1904321
#> 4574 1904322
#> 4575 1904323
#> 4576 1904324
#> 4577 1904325
#> 4578 1904326
#> 4579 1904327
#> 4580 1904328
#> 4581 1904329
#> 4582 1904330
#> 4583 1904331
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#> 4585 1904333
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#> 4587 1904336
#> 4588 1904340
#> 4589 1904341
#> 4590 1904342
#> 4591 1904343
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#> 4594 1904347
#> 4595 1904349
#> 4596 1904350
#> 4597 1904351
#> 4598 1904352
#> 4599 1904353
#> 4600 1904473
#> 4601 1904474
#> 4602 1904475
#> 4603 1904478
#> 4604 1904544
#> 4605 1904545
#> 4606 1904552
#> 4607 1904555
#> 4608 1904558
#> 4609 1904561
#> 4610 1904564
#> 4611 1905727
#> 4612 1905794
#> 4613 1908699
#> 4614 1909240
#> 4615 1909241
#> 4616 1909242
#> 4617 1909243
#> 4618 1909248
#> 4619 1909251
#> 4620 1909685
#> 4621 1909886
#> 4622 1909888
#> 4623 1909890
#> 4624 1909899
#> 4625 1910562
#> 4626 1912865
#> 4627 1913054
#> 4628 1913374
#> 4629 1913459
#> 4630 1913505
#> 4631 1913676
#> 4632 1913717
#> 4633 1913718
#> 4634 1913804
#> 4635 1913805
#> 4636 1913871
#> 4637 1914046
#> 4638 1914053
#> 4639 1914125
#> 4640 1914203
#> 4641 1914311
#> 4642 1914653
#> 4643 1914684
#> 4644 1914919
#> 4645 1914976
#> 4646 1915188
#> 4647 1915407
#> 4648 1915408
#> 4649 1915409
#> 4650 1915410
#> 4651 1915467
#> 4652 1915468
#> 4653 1915469
#> 4654 1915535
#> 4655 1915572
#> 4656 1915575
#> 4657 1915576
#> 4658 1915577
#> 4659 1915677
#> 4660 1915678
#> 4661 1915679
#> 4662 1915685
#> 4663 1915688
#> 4664 1915689
#> 4665 1915690
#> 4666 1915691
#> 4667 1915692
#> 4668 1915693
#> 4669 1915694
#> 4670 1915697
#> 4671 1915698
#> 4672 1915699
#> 4673 1915705
#> 4674 1915719
#> 4675 1916784
#> 4676 1919057
#> 4677 1919092
#> 4678 1919093
#> 4679 1919180
#> 4680 1919215
#> 4681 1919300
#> 4682 1919455
#> 4683 1919495
#> 4684 1919607
#> 4685 1919644
#> 4686 1919678
#> 4687 1919849
#> 4688 1919856
#> 4689 1919928
#> 4690 1919985
#> 4691 1919999
#> 4692 1920013
#> 4693 1920045
#> 4694 1920191
#> 4695 1921360
#> 4696 1921363
#> 4697 1921364
#> 4698 1921814
#> 4699 1921815
#> 4700 1921816
#> 4701 1922095
#> 4702 1922295
#> 4703 1923076
#> 4704 1923183
#> 4705 1924191
#> 4706 1924659
#> 4707 1925327
#> 4708 1925450
#> 4709 1925467
#> 4710 1925476
#> 4711 1925478
#> 4712 1925485
#> 4713 1925497
#> 4714 1925499
#> 4715 1925501
#> 4716 1925516
#> 4717 1925517
#> 4718 1927458
#> 4719 1927644
#> 4720 1927645
#> 4721 1927646
#> 4722 1927647
#> 4723 1927649
#> 4724 1927651
#> 4725 1927653
#> 4726 1927658
#> 4727 1927669
#> 4728 1927678
#> 4729 1927684
#> 4730 1927685
#> 4731 1927691
#> 4732 1927695
#> 4733 1927699
#> 4734 1927701
#> 4735 1927702
#> 4736 1927705
#> 4737 1927706
#> 4738 1927707
#> 4739 1927712
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#> 4741 1927715
#> 4742 1927716
#> 4743 1927717
#> 4744 1928276
#> 4745 1928914
#> 4746 1929371
#> 4747 1929375
#> 4748 1930037
#> 4749 1930755
#> 4750 1930756
#> 4751 1933403
#> 4752 1934726
#> 4753 1934848
#> 4754 1935444
#> 4755 1935462
#> 4756 1935464
#> 4757 1936611
#> 4758 1936712
#> 4759 1937347
#> 4760 1937700
#> 4761 1937704
#> 4762 1937919
#> 4763 1937920
#> 4764 1939172
#> 4765 1939174
#> 4766 1939436
#> 4767 1939605
#> 4768 1939975
#> 4769 1939977
#> 4770 1939981
#> 4771 1939982
#> 4772 1939983
#> 4773 1939984
#> 4774 1940017
#> 4775 1940255
#> 4776 1940841
#> 4777 1941740
#> 4778 1942598
#> 4779 1946252
#> 4780 1946254
#> 4781 1946255
#> 4782 1946507
#> 4783 1946518
#> 4784 1946519
#> 4785 1948213
#> 4786 1948215
#> 4787 1948227
#> 4788 1948241
#> 4789 1948304
#> 4790 1948925
#> 4791 1949540
#> 4792 1949832
#> 4793 1949847
#> 4794 1949848
#> 4795 1949849
#> 4796 1949850
#> 4797 1949857
#> 4798 1949858
#> 4799 1949859
#> 4800 1949860
#> 4801 1949861
#> 4802 1949874
#> 4803 1949875
#> 4804 1949876
#> 4805 1949877
#> 4806 1949878
#> 4807 1949879
#> 4808 1951283
#> 4809 1951284
#> 4810 1951285
#> 4811 1951286
#> 4812 1951287
#> 4813 1951289
#> 4814 1951291
#> 4815 1951304
#> 4816 1951895
#> 4817 1951896
#> 4818 1951897
#> 4819 1951898
#> 4820 1951899
#> 4821 1951900
#> 4822 1951901
#> 4823 1952793
#> 4824 1953122
#> 4825 1953508
#> 4826 1953631
#> 4827 1954449
#> 4828 1954480
#> 4829 1954812
#> 4830 1954813
#> 4831 1955433
#> 4832 1955684
#> 4833 1955685
#> 4834 1955686
#> 4835 1955938
#> 4836 1956454
#> 4837 1956455
#> 4838 1956456
#> 4839 1956457
#> 4840 1956461
#> 4841 1956472
#> 4842 1958843
#> 4843 1959126
#> 4844 1959127
#> 4845 1959130
#> 4846 1959134
#> 4847 1959135
#> 4848 1959136
#> 4849 1959139
#> 4850 1959358
#> 4851 1960665
#> 4852 1960671
#> 4853 1960854
#> 4854 1961744
#> 4855 1962262
#> 4856 1962409
#> 4857 1962577
#> 4858 1963350
#> 4859 1963351
#> 4860 1963502

Bioactivities from Protein: Returns concise bioactivity data for a specific protein. For example:

result <- get_pug_rest(identifier = "Q01279", namespace = "accession", domain = "protein", operation = "concise", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Protein
#>   - Namespace: DomainSpecific
#>   - Operation: concise
#>   - Identifier: Q01279
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#>  [1] "AID"                 "SID"                 "CID"                
#>  [4] "Activity Outcome"    "Target GeneID"       "Activity Value [uM]"
#>  [7] "Activity Name"       "Assay Name"          "Assay Type"         
#> [10] "PubMed ID"          
#> 
#> 
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#>  [1] "66438"                                                           
#>  [2] "103250953"                                                       
#>  [3] "25017867"                                                        
#>  [4] "Active"                                                          
#>  [5] "13649"                                                           
#>  [6] "0.01"                                                            
#>  [7] "Effective concentration"                                         
#>  [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#>  [9] "Confirmatory"                                                    
#> [10] "1597853"                                                         
#> 
#> 
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#>  [1] "66438"                                                           
#>  [2] "103432098"                                                       
#>  [3] "454217"                                                          
#>  [4] "Active"                                                          
#>  [5] "13649"                                                           
#>  [6] "0.22"                                                            
#>  [7] "Effective concentration"                                         
#>  [8] "Inhibition of epidermal growth factor binding in C3H10T1/2 cells"
#>  [9] "Confirmatory"                                                    
#> [10] "1597853"                                                         
#> 
#> 
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#>  [1] "69721"                                                                              
#>  [2] "103358917"                                                                          
#>  [3] "135512509"                                                                          
#>  [4] "Unspecified"                                                                        
#>  [5] "13649"                                                                              
#>  [6] "22.7"                                                                               
#>  [7] "IC50"                                                                               
#>  [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#>  [9] "Confirmatory"                                                                       
#> [10] "9748366"                                                                            
#> 
#> 
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#>  [1] "69721"                                                                              
#>  [2] "103358918"                                                                          
#>  [3] "135434086"                                                                          
#>  [4] "Unspecified"                                                                        
#>  [5] "13649"                                                                              
#>  [6] "36.9"                                                                               
#>  [7] "IC50"                                                                               
#>  [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#>  [9] "Confirmatory"                                                                       
#> [10] "9748366"                                                                            
#> 
#> 
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#>  [1] "69721"                                                                              
#>  [2] "103358919"                                                                          
#>  [3] "135455949"                                                                          
#>  [4] "Unspecified"                                                                        
#>  [5] "13649"                                                                              
#>  [6] "11.3"                                                                               
#>  [7] "IC50"                                                                               
#>  [8] "Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cells"
#>  [9] "Confirmatory"                                                                       
#> [10] "9748366"                                                                            
#> 
#> 
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103253186"                                                                                                       
#>  [3] "5328592"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "13649"                                                                                                           
#>  [6] "100"                                                                                                             
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> 
#> 
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103253755"                                                                                                       
#>  [3] "5328614"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "13649"                                                                                                           
#>  [6] "100"                                                                                                             
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> 
#> 
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103254313"                                                                                                       
#>  [3] "5328618"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "13649"                                                                                                           
#>  [6] "100"                                                                                                             
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> 
#> 
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#>  [1] "69722"                                                                                                           
#>  [2] "103254592"                                                                                                       
#>  [3] "5328617"                                                                                                         
#>  [4] "Unspecified"                                                                                                     
#>  [5] "13649"                                                                                                           
#>  [6] "25"                                                                                                              
#>  [7] "IC50"                                                                                                            
#>  [8] "Inhibition of epidermal growth factor receptor (EGFR-mediated tyrosine autophosphorylation in mouse fibroblasts."
#>  [9] "Confirmatory"                                                                                                    
#> [10] "8027985"                                                                                                         
#> 
#> 
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103237764"                                                               
#>  [3] "5328042"                                                                 
#>  [4] "Active"                                                                  
#>  [5] "13649"                                                                   
#>  [6] "0.04"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> 
#> 
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103373305"                                                               
#>  [3] "9882519"                                                                 
#>  [4] "Active"                                                                  
#>  [5] "13649"                                                                   
#>  [6] "0.2"                                                                     
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> 
#> 
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103373788"                                                               
#>  [3] "9885081"                                                                 
#>  [4] "Active"                                                                  
#>  [5] "13649"                                                                   
#>  [6] "0.07"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> 
#> 
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103399645"                                                               
#>  [3] "11198415"                                                                
#>  [4] "Active"                                                                  
#>  [5] "13649"                                                                   
#>  [6] "0.578"                                                                   
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> 
#> 
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103399736"                                                               
#>  [3] "10094127"                                                                
#>  [4] "Active"                                                                  
#>  [5] "13649"                                                                   
#>  [6] "0.13"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> 
#> 
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#>  [1] "69724"                                                                   
#>  [2] "103399893"                                                               
#>  [3] "11349700"                                                                
#>  [4] "Active"                                                                  
#>  [5] "13649"                                                                   
#>  [6] "0.11"                                                                    
#>  [7] "IC50"                                                                    
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)"
#>  [9] "Confirmatory"                                                            
#> [10] "14640561"                                                                
#> 
#> 
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#>  [1] "69727"                                                                                  
#>  [2] "103167027"                                                                              
#>  [3] "5280343"                                                                                
#>  [4] "Unspecified"                                                                            
#>  [5] "13649"                                                                                  
#>  [6] ""                                                                                       
#>  [7] ""                                                                                       
#>  [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#>  [9] "Other"                                                                                  
#> [10] "8201603"                                                                                
#> 
#> 
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#>  [1] "69728"                                                                              
#>  [2] "103399857"                                                                          
#>  [3] "44368090"                                                                           
#>  [4] "Inactive"                                                                           
#>  [5] "13649"                                                                              
#>  [6] ""                                                                                   
#>  [7] ""                                                                                   
#>  [8] "Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK) (inactive)"
#>  [9] "Other"                                                                              
#> [10] "14640561"                                                                           
#> 
#> 
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#>  [1] "69729"                                                                                  
#>  [2] "103167027"                                                                              
#>  [3] "5280343"                                                                                
#>  [4] "Unspecified"                                                                            
#>  [5] "13649"                                                                                  
#>  [6] ""                                                                                       
#>  [7] ""                                                                                       
#>  [8] "Inhibition of epidermal growth factor (EGF) receptor from A431 cell membranes at 150 uM"
#>  [9] "Other"                                                                                  
#> [10] "8201603"                                                                                
#> 
#> 
#> $Table$Row[[19]]
#> $Table$Row[[19]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103226434"                                                                                   
#>  [3] "10318571"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "13649"                                                                                       
#>  [6] "4"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[20]]
#> $Table$Row[[20]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103350640"                                                                                   
#>  [3] "10406106"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "14"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[21]]
#> $Table$Row[[21]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103378973"                                                                                   
#>  [3] "10738302"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "33"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[22]]
#> $Table$Row[[22]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103378974"                                                                                   
#>  [3] "10761144"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "200"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[23]]
#> $Table$Row[[23]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379003"                                                                                   
#>  [3] "10044189"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "500"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[24]]
#> $Table$Row[[24]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379199"                                                                                   
#>  [3] "10428841"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "13649"                                                                                       
#>  [6] "8"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[25]]
#> $Table$Row[[25]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379200"                                                                                   
#>  [3] "10716388"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "100"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[26]]
#> $Table$Row[[26]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379360"                                                                                   
#>  [3] "10452792"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "50"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[27]]
#> $Table$Row[[27]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379591"                                                                                   
#>  [3] "10620637"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "300"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[28]]
#> $Table$Row[[28]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379616"                                                                                   
#>  [3] "10593843"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "100"                                                                                         
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[29]]
#> $Table$Row[[29]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379617"                                                                                   
#>  [3] "10787405"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "13649"                                                                                       
#>  [6] "4"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[30]]
#> $Table$Row[[30]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379660"                                                                                   
#>  [3] "10343317"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "35"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[31]]
#> $Table$Row[[31]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379661"                                                                                   
#>  [3] "10499929"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "15"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[32]]
#> $Table$Row[[32]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379682"                                                                                   
#>  [3] "10500718"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "13649"                                                                                       
#>  [6] "1"                                                                                           
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[33]]
#> $Table$Row[[33]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379908"                                                                                   
#>  [3] "10619651"                                                                                    
#>  [4] "Active"                                                                                      
#>  [5] "13649"                                                                                       
#>  [6] "10"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[34]]
#> $Table$Row[[34]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379909"                                                                                   
#>  [3] "10504027"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "35"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[35]]
#> $Table$Row[[35]]$Cell
#>  [1] "69730"                                                                                       
#>  [2] "103379910"                                                                                   
#>  [3] "10740438"                                                                                    
#>  [4] "Unspecified"                                                                                 
#>  [5] "13649"                                                                                       
#>  [6] "46"                                                                                          
#>  [7] "IC50"                                                                                        
#>  [8] "Inhibition of epidermal growth factor receptor phosphorylation in BaF3 mouse lymphoid cells."
#>  [9] "Confirmatory"                                                                                
#> [10] "11462983"                                                                                    
#> 
#> 
#> $Table$Row[[36]]
#> $Table$Row[[36]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166113"                                                           
#>  [3] "10499619"                                                            
#>  [4] "Active"                                                              
#>  [5] "13649"                                                               
#>  [6] "9.55"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[37]]
#> $Table$Row[[37]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166157"                                                           
#>  [3] "9978638"                                                             
#>  [4] "Active"                                                              
#>  [5] "13649"                                                               
#>  [6] "4.93"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[38]]
#> $Table$Row[[38]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166217"                                                           
#>  [3] "10590515"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "13649"                                                               
#>  [6] "45.2"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[39]]
#> $Table$Row[[39]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166266"                                                           
#>  [3] "10803234"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "13649"                                                               
#>  [6] "10.2"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[40]]
#> $Table$Row[[40]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166322"                                                           
#>  [3] "2051"                                                                
#>  [4] "Active"                                                              
#>  [5] "13649"                                                               
#>  [6] "0.1"                                                                 
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[41]]
#> $Table$Row[[41]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166323"                                                           
#>  [3] "10850934"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "13649"                                                               
#>  [6] "16"                                                                  
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[42]]
#> $Table$Row[[42]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166405"                                                           
#>  [3] "9883384"                                                             
#>  [4] "Active"                                                              
#>  [5] "13649"                                                               
#>  [6] "2.83"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[43]]
#> $Table$Row[[43]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166415"                                                           
#>  [3] "10494548"                                                            
#>  [4] "Unspecified"                                                         
#>  [5] "13649"                                                               
#>  [6] "11.4"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[44]]
#> $Table$Row[[44]]$Cell
#>  [1] "106697"                                                              
#>  [2] "103166416"                                                           
#>  [3] "689033"                                                              
#>  [4] "Unspecified"                                                         
#>  [5] "13649"                                                               
#>  [6] "46.2"                                                                
#>  [7] "IC50"                                                                
#>  [8] "Inhibition of EGF-dependent mouse keratinocyte MK cell proliferation"
#>  [9] "Confirmatory"                                                        
#> [10] "10090785"                                                            
#> 
#> 
#> $Table$Row[[45]]
#> $Table$Row[[45]]$Cell
#>  [1] "209326"                                                   
#>  [2] "103257455"                                                
#>  [3] "2428"                                                     
#>  [4] "Active"                                                   
#>  [5] "13649"                                                    
#>  [6] "0.046"                                                    
#>  [7] "IC50"                                                     
#>  [8] "Inhibition of EGF-mediated mitogenesis in Swiss 3T3 cells"
#>  [9] "Confirmatory"                                             
#> [10] "8632415"                                                  
#> 
#> 
#> $Table$Row[[46]]
#> $Table$Row[[46]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439646"                                                  
#>  [3] "10209082"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[47]]
#> $Table$Row[[47]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439659"                                                  
#>  [3] "10185160"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[48]]
#> $Table$Row[[48]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439663"                                                  
#>  [3] "10143584"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[49]]
#> $Table$Row[[49]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439672"                                                  
#>  [3] "10163439"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[50]]
#> $Table$Row[[50]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439700"                                                  
#>  [3] "10302405"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[51]]
#> $Table$Row[[51]]$Cell
#>  [1] "241562"                                                     
#>  [2] "103439717"                                                  
#>  [3] "10187378"                                                   
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[52]]
#> $Table$Row[[52]]$Cell
#>  [1] "241562"                                                     
#>  [2] "123092436"                                                  
#>  [3] "44259"                                                      
#>  [4] "Unspecified"                                                
#>  [5] "13649"                                                      
#>  [6] "10"                                                         
#>  [7] "IC50"                                                       
#>  [8] "Inhibition of Epidermal growth factor receptor in P19 cells"
#>  [9] "Confirmatory"                                               
#> [10] "15771419"                                                   
#> 
#> 
#> $Table$Row[[53]]
#> $Table$Row[[53]]$Cell
#>  [1] "241823"                                                                             
#>  [2] "103452251"                                                                          
#>  [3] "22732319"                                                                           
#>  [4] "Inconclusive"                                                                       
#>  [5] "13649"                                                                              
#>  [6] ""                                                                                   
#>  [7] ""                                                                                   
#>  [8] "Inhibition of Epidermal growth factor receptor tyrosine kinase activity; not tested"
#>  [9] "Other"                                                                              
#> [10] "15454232"                                                                           
#> 
#> 
#> $Table$Row[[54]]
#> $Table$Row[[54]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103194285"                                                
#>  [3] "4075"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[55]]
#> $Table$Row[[55]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103227545"                                                
#>  [3] "5328552"                                                  
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[56]]
#> $Table$Row[[56]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103319670"                                                
#>  [3] "3894"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[57]]
#> $Table$Row[[57]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103319671"                                                
#>  [3] "3896"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[58]]
#> $Table$Row[[58]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103529702"                                                
#>  [3] "65083"                                                    
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[59]]
#> $Table$Row[[59]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103529722"                                                
#>  [3] "70949"                                                    
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[60]]
#> $Table$Row[[60]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618685"                                                
#>  [3] "3895"                                                     
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[61]]
#> $Table$Row[[61]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618686"                                                
#>  [3] "44593598"                                                 
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[62]]
#> $Table$Row[[62]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618687"                                                
#>  [3] "44593599"                                                 
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[63]]
#> $Table$Row[[63]]$Cell
#>  [1] "337238"                                                   
#>  [2] "103618691"                                                
#>  [3] "375472"                                                   
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[64]]
#> $Table$Row[[64]]$Cell
#>  [1] "337238"                                                   
#>  [2] "123092436"                                                
#>  [3] "44259"                                                    
#>  [4] "Unspecified"                                              
#>  [5] "13649"                                                    
#>  [6] ""                                                         
#>  [7] ""                                                         
#>  [8] "Inhibition of mouse EGFR by liquid scintillation counting"
#>  [9] "Other"                                                    
#> [10] "2614420"                                                  
#> 
#> 
#> $Table$Row[[65]]
#> $Table$Row[[65]]$Cell
#>  [1] "337243"                                                                                        
#>  [2] "103319670"                                                                                     
#>  [3] "3894"                                                                                          
#>  [4] "Active"                                                                                        
#>  [5] "13649"                                                                                         
#>  [6] ""                                                                                              
#>  [7] ""                                                                                              
#>  [8] "Inhibition of mouse EGFR using [32P]gammaATP as substrate by competitive Lineweaver-Burke plot"
#>  [9] "Other"                                                                                         
#> [10] "2614420"                                                                                       
#> 
#> 
#> $Table$Row[[66]]
#> $Table$Row[[66]]$Cell
#>  [1] "337244"                                                                                           
#>  [2] "103319670"                                                                                        
#>  [3] "3894"                                                                                             
#>  [4] "Active"                                                                                           
#>  [5] "13649"                                                                                            
#>  [6] ""                                                                                                 
#>  [7] ""                                                                                                 
#>  [8] "Inhibition of mouse EGFR using tridecapeptide as substrate by uncompetitive Lineweaver-Burke plot"
#>  [9] "Other"                                                                                            
#> [10] "2614420"                                                                                          
#> 
#> 
#> $Table$Row[[67]]
#> $Table$Row[[67]]$Cell
#>  [1] "415757"                                                                                  
#>  [2] "103294831"                                                                               
#>  [3] "5289418"                                                                                 
#>  [4] "Active"                                                                                  
#>  [5] "13649"                                                                                   
#>  [6] ""                                                                                        
#>  [7] ""                                                                                        
#>  [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#>  [9] "Other"                                                                                   
#> [10] "9139660"                                                                                 
#> 
#> 
#> $Table$Row[[68]]
#> $Table$Row[[68]]$Cell
#>  [1] "415757"                                                                                  
#>  [2] "103295395"                                                                               
#>  [3] "5941540"                                                                                 
#>  [4] "Active"                                                                                  
#>  [5] "13649"                                                                                   
#>  [6] ""                                                                                        
#>  [7] ""                                                                                        
#>  [8] "Inhibition of EGF-stimulated EGFR phosphorylation in mouse HER14 cells by immunoblotting"
#>  [9] "Other"                                                                                   
#> [10] "9139660"                                                                                 
#> 
#> 
#> $Table$Row[[69]]
#> $Table$Row[[69]]$Cell
#>  [1] "415758"                                                                                                                
#>  [2] "103294831"                                                                                                             
#>  [3] "5289418"                                                                                                               
#>  [4] "Active"                                                                                                                
#>  [5] "13649"                                                                                                                 
#>  [6] ""                                                                                                                      
#>  [7] ""                                                                                                                      
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#>  [9] "Other"                                                                                                                 
#> [10] "9139660"                                                                                                               
#> 
#> 
#> $Table$Row[[70]]
#> $Table$Row[[70]]$Cell
#>  [1] "415758"                                                                                                                
#>  [2] "103295395"                                                                                                             
#>  [3] "5941540"                                                                                                               
#>  [4] "Active"                                                                                                                
#>  [5] "13649"                                                                                                                 
#>  [6] ""                                                                                                                      
#>  [7] ""                                                                                                                      
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting"
#>  [9] "Other"                                                                                                                 
#> [10] "9139660"                                                                                                               
#> 
#> 
#> $Table$Row[[71]]
#> $Table$Row[[71]]$Cell
#>  [1] "415759"                                                                                                            
#>  [2] "103294831"                                                                                                         
#>  [3] "5289418"                                                                                                           
#>  [4] "Active"                                                                                                            
#>  [5] "13649"                                                                                                             
#>  [6] ""                                                                                                                  
#>  [7] ""                                                                                                                  
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#>  [9] "Other"                                                                                                             
#> [10] "9139660"                                                                                                           
#> 
#> 
#> $Table$Row[[72]]
#> $Table$Row[[72]]$Cell
#>  [1] "415759"                                                                                                            
#>  [2] "103295395"                                                                                                         
#>  [3] "5941540"                                                                                                           
#>  [4] "Active"                                                                                                            
#>  [5] "13649"                                                                                                             
#>  [6] ""                                                                                                                  
#>  [7] ""                                                                                                                  
#>  [8] "Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated ERK2 activation by immunoblotting"
#>  [9] "Other"                                                                                                             
#> [10] "9139660"                                                                                                           
#> 
#> 
#> $Table$Row[[73]]
#> $Table$Row[[73]]$Cell
#>  [1] "415760"                                                             
#>  [2] "103294831"                                                          
#>  [3] "5289418"                                                            
#>  [4] "Inactive"                                                           
#>  [5] "13649"                                                              
#>  [6] ""                                                                   
#>  [7] ""                                                                   
#>  [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#>  [9] "Other"                                                              
#> [10] "9139660"                                                            
#> 
#> 
#> $Table$Row[[74]]
#> $Table$Row[[74]]$Cell
#>  [1] "415760"                                                             
#>  [2] "103295395"                                                          
#>  [3] "5941540"                                                            
#>  [4] "Inactive"                                                           
#>  [5] "13649"                                                              
#>  [6] ""                                                                   
#>  [7] ""                                                                   
#>  [8] "Inhibition of EGFR phosphorylation in mouse NIH/3T3 cells at 200 uM"
#>  [9] "Other"                                                              
#> [10] "9139660"                                                            
#> 
#> 
#> $Table$Row[[75]]
#> $Table$Row[[75]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "312367127"                                                                                                                                                          
#>  [3] "71496458"                                                                                                                                                           
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "0.081"                                                                                                                                                              
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[76]]
#> $Table$Row[[76]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440110169"                                                                                                                                                          
#>  [3] "139593669"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "13649"                                                                                                                                                              
#>  [6] "10"                                                                                                                                                                 
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[77]]
#> $Table$Row[[77]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440119817"                                                                                                                                                          
#>  [3] "155517202"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "13649"                                                                                                                                                              
#>  [6] ""                                                                                                                                                                   
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[78]]
#> $Table$Row[[78]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440125045"                                                                                                                                                          
#>  [3] "139447864"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "3.6"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[79]]
#> $Table$Row[[79]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440160302"                                                                                                                                                          
#>  [3] "139593670"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "1.3"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[80]]
#> $Table$Row[[80]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440163841"                                                                                                                                                          
#>  [3] "139447649"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "5.1"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[81]]
#> $Table$Row[[81]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440172005"                                                                                                                                                          
#>  [3] "139447554"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "0.7"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[82]]
#> $Table$Row[[82]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440176009"                                                                                                                                                          
#>  [3] "139600318"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "0.19"                                                                                                                                                               
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[83]]
#> $Table$Row[[83]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440182946"                                                                                                                                                          
#>  [3] "155444794"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "2.3"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[84]]
#> $Table$Row[[84]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440203081"                                                                                                                                                          
#>  [3] "155444797"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "1.1"                                                                                                                                                                
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[85]]
#> $Table$Row[[85]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440207922"                                                                                                                                                          
#>  [3] "155444848"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "0.27"                                                                                                                                                               
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[86]]
#> $Table$Row[[86]]$Cell
#>  [1] "1527521"                                                                                                                                                            
#>  [2] "440227038"                                                                                                                                                          
#>  [3] "139593668"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "13649"                                                                                                                                                              
#>  [6] ""                                                                                                                                                                   
#>  [7] "IC50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "31689114"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[87]]
#> $Table$Row[[87]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "312367127"                                                                                                                                                          
#>  [3] "71496458"                                                                                                                                                           
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "2.6"                                                                                                                                                                
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[88]]
#> $Table$Row[[88]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461515468"                                                                                                                                                          
#>  [3] "162643657"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "13649"                                                                                                                                                              
#>  [6] ""                                                                                                                                                                   
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[89]]
#> $Table$Row[[89]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461515649"                                                                                                                                                          
#>  [3] "162643790"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "9.23"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[90]]
#> $Table$Row[[90]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461542097"                                                                                                                                                          
#>  [3] "162662364"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "3.91"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[91]]
#> $Table$Row[[91]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461543217"                                                                                                                                                          
#>  [3] "162663118"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "13649"                                                                                                                                                              
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[92]]
#> $Table$Row[[92]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461546315"                                                                                                                                                          
#>  [3] "162665339"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "13649"                                                                                                                                                              
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[93]]
#> $Table$Row[[93]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461547480"                                                                                                                                                          
#>  [3] "162666122"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "4.27"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[94]]
#> $Table$Row[[94]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461549927"                                                                                                                                                          
#>  [3] "162667840"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "3.79"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[95]]
#> $Table$Row[[95]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461550238"                                                                                                                                                          
#>  [3] "162668052"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "2.65"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[96]]
#> $Table$Row[[96]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461550466"                                                                                                                                                          
#>  [3] "162668204"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "13649"                                                                                                                                                              
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[97]]
#> $Table$Row[[97]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461555362"                                                                                                                                                          
#>  [3] "162671649"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "13649"                                                                                                                                                              
#>  [6] ""                                                                                                                                                                   
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[98]]
#> $Table$Row[[98]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461557317"                                                                                                                                                          
#>  [3] "162673094"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "9.23"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[99]]
#> $Table$Row[[99]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461557891"                                                                                                                                                          
#>  [3] "162673491"                                                                                                                                                          
#>  [4] "Active"                                                                                                                                                             
#>  [5] "13649"                                                                                                                                                              
#>  [6] "3.79"                                                                                                                                                               
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[100]]
#> $Table$Row[[100]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461558880"                                                                                                                                                          
#>  [3] "162674154"                                                                                                                                                          
#>  [4] "Inconclusive"                                                                                                                                                       
#>  [5] "13649"                                                                                                                                                              
#>  [6] ""                                                                                                                                                                   
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[101]]
#> $Table$Row[[101]]$Cell
#>  [1] "1740135"                                                                                                                                                            
#>  [2] "461562991"                                                                                                                                                          
#>  [3] "162677073"                                                                                                                                                          
#>  [4] "Unspecified"                                                                                                                                                        
#>  [5] "13649"                                                                                                                                                              
#>  [6] "10"                                                                                                                                                                 
#>  [7] "GI50"                                                                                                                                                               
#>  [8] "Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay"
#>  [9] "Confirmatory"                                                                                                                                                       
#> [10] "32619886"                                                                                                                                                           
#> 
#> 
#> $Table$Row[[102]]
#> $Table$Row[[102]]$Cell
#>  [1] "1815786"                                                                                                                                        
#>  [2] "475982343"                                                                                                                                      
#>  [3] "166627448"                                                                                                                                      
#>  [4] "Unspecified"                                                                                                                                    
#>  [5] "13649"                                                                                                                                          
#>  [6] ""                                                                                                                                               
#>  [7] ""                                                                                                                                               
#>  [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR 19Del/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#>  [9] "Other"                                                                                                                                          
#> [10] "35178175"                                                                                                                                       
#> 
#> 
#> $Table$Row[[103]]
#> $Table$Row[[103]]$Cell
#>  [1] "1815820"                                                                                                                                        
#>  [2] "475982343"                                                                                                                                      
#>  [3] "166627448"                                                                                                                                      
#>  [4] "Unspecified"                                                                                                                                    
#>  [5] "13649"                                                                                                                                          
#>  [6] ""                                                                                                                                               
#>  [7] ""                                                                                                                                               
#>  [8] "Inhibition of EGFR phosphorylation in mouse BaF3 cells expressing EGFR L858R/T790M/C797S triple mutant measured after 2 hrs by Western blotting"
#>  [9] "Other"                                                                                                                                          
#> [10] "35178175"                                                                                                                                       
#> 
#> 
#> $Table$Row[[104]]
#> $Table$Row[[104]]$Cell
#>  [1] "1862914"                                                                                                                                                                                                                             
#>  [2] "482063640"                                                                                                                                                                                                                           
#>  [3] "155431347"                                                                                                                                                                                                                           
#>  [4] "Active"                                                                                                                                                                                                                              
#>  [5] "13649"                                                                                                                                                                                                                               
#>  [6] ""                                                                                                                                                                                                                                    
#>  [7] ""                                                                                                                                                                                                                                    
#>  [8] "Invivo inhibition of EGFR phosphorylation in nude mouse implanted with mouse BaF3 cells harboring EGFR del18/T790M/C797S triple mutant at 20 mg/kg, po administered as single dose and measured upto 24 hrs by Western blot analysis"
#>  [9] "Other"                                                                                                                                                                                                                               
#> [10] "35810715"                                                                                                                                                                                                                            
#> 
#> 
#> $Table$Row[[105]]
#> $Table$Row[[105]]$Cell
#>  [1] "1896806"                                                                                                                                           
#>  [2] "482061797"                                                                                                                                         
#>  [3] "166176964"                                                                                                                                         
#>  [4] "Unspecified"                                                                                                                                       
#>  [5] "13649"                                                                                                                                             
#>  [6] ""                                                                                                                                                  
#>  [7] ""                                                                                                                                                  
#>  [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#>  [9] "Other"                                                                                                                                             
#> [10] "36384036"                                                                                                                                          
#> 
#> 
#> $Table$Row[[106]]
#> $Table$Row[[106]]$Cell
#>  [1] "1896806"                                                                                                                                           
#>  [2] "482062269"                                                                                                                                         
#>  [3] "168280117"                                                                                                                                         
#>  [4] "Unspecified"                                                                                                                                       
#>  [5] "13649"                                                                                                                                             
#>  [6] ""                                                                                                                                                  
#>  [7] ""                                                                                                                                                  
#>  [8] "Inhibition of Wild type EGFR in mouse BaF3 cells assessed as protein phosphorylation at 10 to 1000 nM incubated for 8 hrs by Western blot analysis"
#>  [9] "Other"                                                                                                                                             
#> [10] "36384036"

Pathways from Protein: Provides a list of pathways involving a specific protein. For example, for protein accession P00533:

result <- get_pug_rest(identifier = "P00533", namespace = "accession", domain = "protein", operation = "pwaccs", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Protein
#>   - Namespace: DomainSpecific
#>   - Operation: pwaccs
#>   - Identifier: P00533
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>                                                            Text
#> 1                                           PathBank:SMP0000472
#> 2                                           PathBank:SMP0000473
#> 3                                           PathBank:SMP0000474
#> 4                                           PathBank:SMP0000475
#> 5                                           PathBank:SMP0000476
#> 6                                           PathBank:SMP0063810
#> 7                                           PathBank:SMP0063811
#> 8       Pathway Interaction Database:a6b1_a6b4_integrin_pathway
#> 9                  Pathway Interaction Database:ajdiss_2pathway
#> 10                    Pathway Interaction Database:arf6_pathway
#> 11  Pathway Interaction Database:ecadherin_keratinocyte_pathway
#> 12 Pathway Interaction Database:ecadherin_stabilization_pathway
#> 13        Pathway Interaction Database:erbb1_downstream_pathway
#> 14   Pathway Interaction Database:erbb1_internalization_pathway
#> 15            Pathway Interaction Database:erbb_network_pathway
#> 16                  Pathway Interaction Database:et_egfrpathway
#> 17        Pathway Interaction Database:lysophospholipid_pathway
#> 18            Pathway Interaction Database:p53downstreampathway
#> 19                    Pathway Interaction Database:ptp1bpathway
#> 20                    Pathway Interaction Database:shp2_pathway
#> 21              Pathway Interaction Database:syndecan_3_pathway
#> 22                   Pathway Interaction Database:tcptp_pathway
#> 23               Pathway Interaction Database:telomerasepathway
#> 24                     Pathway Interaction Database:txa2pathway
#> 25                Pathway Interaction Database:upa_upar_pathway
#> 26                                         PharmGKB:PA152325160
#> 27                                         PharmGKB:PA154426903
#> 28                                         PharmGKB:PA162356267
#> 29                                         PharmGKB:PA165980050
#> 30                                       Reactome:R-HSA-1227986
#> 31                                       Reactome:R-HSA-1227990
#> 32                                       Reactome:R-HSA-1236394
#> 33                                       Reactome:R-HSA-1266738
#> 34                                        Reactome:R-HSA-157118
#> 35                                        Reactome:R-HSA-162582
#> 36                                       Reactome:R-HSA-1643685
#> 37                                       Reactome:R-HSA-1643713
#> 38                                        Reactome:R-HSA-177929
#> 39                                        Reactome:R-HSA-179812
#> 40                                        Reactome:R-HSA-180292
#> 41                                        Reactome:R-HSA-180336
#> 42                                        Reactome:R-HSA-182971
#> 43                                        Reactome:R-HSA-199991
#> 44                                        Reactome:R-HSA-212436
#> 45                                        Reactome:R-HSA-212718
#> 46                                       Reactome:R-HSA-2179392
#> 47                                        Reactome:R-HSA-372790
#> 48                                        Reactome:R-HSA-373760
#> 49                                        Reactome:R-HSA-388396
#> 50                                        Reactome:R-HSA-416476
#> 51                                        Reactome:R-HSA-422475
#> 52                                        Reactome:R-HSA-445144
#> 53                                       Reactome:R-HSA-5637810
#> 54                                       Reactome:R-HSA-5637812
#> 55                                       Reactome:R-HSA-5638302
#> 56                                       Reactome:R-HSA-5638303
#> 57                                       Reactome:R-HSA-5653656
#> 58                                       Reactome:R-HSA-5663202
#> 59                                         Reactome:R-HSA-73857
#> 60                                         Reactome:R-HSA-74160
#> 61                                        Reactome:R-HSA-881907
#> 62                                       Reactome:R-HSA-8848021
#> 63                                       Reactome:R-HSA-8856825
#> 64                                       Reactome:R-HSA-8856828
#> 65                                       Reactome:R-HSA-8857538
#> 66                                       Reactome:R-HSA-8864260
#> 67                                       Reactome:R-HSA-8866910
#> 68                                       Reactome:R-HSA-8939211
#> 69                                       Reactome:R-HSA-9006927
#> 70                                       Reactome:R-HSA-9006931
#> 71                                       Reactome:R-HSA-9006934
#> 72                                       Reactome:R-HSA-9009391
#> 73                                       Reactome:R-HSA-9012852
#> 74                                       Reactome:R-HSA-9013507
#> 75                                       Reactome:R-HSA-9634638
#> 76                                       Reactome:R-HSA-9664565
#> 77                                       Reactome:R-HSA-9665348
#> 78                                       Reactome:R-HSA-9665686
#> 79                                       Reactome:R-HSA-9675108
#> 80                                          WikiPathways:WP1984
#> 81                                          WikiPathways:WP2643
#> 82                                          WikiPathways:WP2840
#> 83                                          WikiPathways:WP5144
#> 84                                          WikiPathways:WP5158
#> 85                                          WikiPathways:WP5322

These methods offer a comprehensive approach to accessing and analyzing protein-related data in PubChem, supporting a wide range of research applications in the fields of biochemistry, molecular biology, and pharmacology.

3.6. Pathways

PubChem’s PUG REST service offers a detailed and comprehensive approach to accessing pathway information, crucial for researchers in fields like bioinformatics, pharmacology, and molecular biology. Here’s how to utilize PUG REST for pathway-related queries:

1. Pathway Input Methods:

By Pathway Accession: The primary method to access pathway data in PubChem. Pathway Accession is formatted as Source:ID. For example, to get a summary for the Reactome pathway R-HSA-70171 in JSON format:

result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: DomainSpecific (pathway)
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: Reactome:R-HSA-70171
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $PathwaySummaries
#> $PathwaySummaries$PathwaySummary
#> $PathwaySummaries$PathwaySummary[[1]]
#> $PathwaySummaries$PathwaySummary[[1]]$PathwayAccession
#> [1] "Reactome:R-HSA-70171"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$SourceName
#> [1] "Reactome"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$SourceID
#> [1] "R-HSA-70171"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$SourceURL
#> [1] "https://reactome.org/content/detail/R-HSA-70171"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Name
#> [1] "Glycolysis"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Type
#> [1] "organism_specific"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Category
#> [1] "pathway"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Description
#> [1] "The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate."
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"

2. Available Pathway Data:

Pathway Summary: Returns a summary including PathwayAccession, SourceName, Name, Type, Category, Description, TaxonomyID, and Taxonomy. For example:

result <- get_pug_rest(identifier = "Reactome:R-HSA-70171,BioCyc:HUMAN_PWY-4983", namespace = "pwacc", domain = "pathway", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: DomainSpecific (pathway)
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: Reactome:R-HSA-70171,BioCyc:HUMAN_PWY-4983
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $PathwaySummaries
#> $PathwaySummaries$PathwaySummary
#> $PathwaySummaries$PathwaySummary[[1]]
#> $PathwaySummaries$PathwaySummary[[1]]$PathwayAccession
#> [1] "Reactome:R-HSA-70171"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$SourceName
#> [1] "Reactome"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$SourceID
#> [1] "R-HSA-70171"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$SourceURL
#> [1] "https://reactome.org/content/detail/R-HSA-70171"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Name
#> [1] "Glycolysis"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Type
#> [1] "organism_specific"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Category
#> [1] "pathway"
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Description
#> [1] "The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate."
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $PathwaySummaries$PathwaySummary[[1]]$Taxonomy
#> [1] "Homo sapiens (human)"
#> 
#> 
#> $PathwaySummaries$PathwaySummary[[2]]
#> $PathwaySummaries$PathwaySummary[[2]]$PathwayAccession
#> [1] "BioCyc:HUMAN_PWY-4983"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$SourceName
#> [1] "BioCyc"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$SourceID
#> [1] "PWY-4983"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$SourceURL
#> [1] "https://biocyc.org/pathway?orgid=HUMAN&id=PWY-4983"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$Name
#> [1] "citrulline-nitric oxide cycle"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$Type
#> [1] "organism_specific"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$Category
#> [1] "pathway"
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$Description
#> [1] "<b>General Background</b>\n\n|FRAME: NITRIC-OXIDE \"Nitric oxide\"| (NO) is the active moiety of the endothelium-derived relaxing factor. In the vasculature NO relaxes smooth muscle and inhibits platelet and leukocyte adhesion. Outside the vasculature, NO participates in the immunologic response to infection. It serves as a neurotransmitter and plays an important role in cell signaling in the nervous system, and in synaptic plasticity. \n\nNitric oxide synthases are a family of enzymes responsible for the NADPH dependent synthesis of nitric oxide from |FRAME: ARG| and oxygen in the |FRAME: PWY-4983|.\n\n<b>About this Pathway</b>\n\n|FRAME: NITRIC-OXIDE \"Nitric oxide\"| can be synthesized by three nitric oxide synthases from |FRAME: ARG| generating |FRAME:L-CITRULLINE| as a by-product. In this cycle, arginine forms NO and citrulline, and is subsequently regenerated from citrulline by the action of the enzymes |FRAME:CPLX-6641| and |FRAME:CPLX-6661|. These two enzymes are shared with the |FRAME: PWY-4984|. Citrulline is also required in |FRAME: PWY-4921|.\n\nThe citrulline-NO cycle functions in many different types of cells. It has been demonstrated in epithelial cells, chondrocytes, endothelial cells, macrophages and neurons |CITS: [2236071]||CITS:[1731766]|.\n\nThe enzymes |FRAME: CPLX-6641| and |FRAME: CPLX-6661| confer cells with the capacity to produce NO without the need for exogenous arginine. In vascular smooth muscle cells |FRAME: CPLX-6661| is constitutively expressed but |FRAME: CPLX-6641| is inducible by cytokines and bacterial endotoxin |CITS:[7511585]|."
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$TaxonomyID
#> [1] 9606
#> 
#> $PathwaySummaries$PathwaySummary[[2]]$Taxonomy
#> [1] "Homo sapiens (human)"

Compounds from Pathway: Retrieves a list of compounds involved in a specific pathway. For example, for the Reactome pathway R-HSA-70171:

result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "cids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: DomainSpecific (pathway)
#>   - Namespace: DomainSpecific
#>   - Operation: cids
#>   - Identifier: Reactome:R-HSA-70171
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>        Text
#> 1       223
#> 2       311
#> 3       753
#> 4       813
#> 5       888
#> 6       962
#> 7      1038
#> 8     65246
#> 9     79025
#> 10    82400
#> 11   105021
#> 12   107735
#> 13   152306
#> 14   439217
#> 15  3674425
#> 16  3681305
#> 17  4643300
#> 18  5460765
#> 19  5461108
#> 20  7058055
#> 21  7059571
#> 22  9548671
#> 23 15938965
#> 24 15938971
#> 25 21604863
#> 26 21604864
#> 27 21604869
#> 28 24794350
#> 29 25245548
#> 30 40467846
#> 31 45266541
#> 32 46878409

Genes from Pathway: Provides a list of genes involved in a specific pathway. For example, for the Reactome pathway R-HSA-70171:

result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "geneids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: DomainSpecific (pathway)
#>   - Namespace: DomainSpecific
#>   - Operation: geneids
#>   - Identifier: Reactome:R-HSA-70171
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>      Text
#> 1     226
#> 2     229
#> 3     230
#> 4     669
#> 5    2023
#> 6    2026
#> 7    2027
#> 8    2597
#> 9    2645
#> 10   2646
#> 11   2821
#> 12   4927
#> 13   5207
#> 14   5208
#> 15   5209
#> 16   5210
#> 17   5211
#> 18   5213
#> 19   5214
#> 20   5223
#> 21   5224
#> 22   5230
#> 23   5232
#> 24   5528
#> 25   5903
#> 26   6396
#> 27   7167
#> 28   7175
#> 29   8021
#> 30   8086
#> 31   8480
#> 32   9631
#> 33   9688
#> 34   9972
#> 35  10007
#> 36  10762
#> 37  11097
#> 38  23165
#> 39  23225
#> 40  23279
#> 41  23511
#> 42  23636
#> 43  26330
#> 44  53371
#> 45  55706
#> 46  55746
#> 47  57122
#> 48  79023
#> 49  79902
#> 50  83440
#> 51 129401
#> 52 132789
#> 53 283209
#> 54 283871
#> 55 348995
#> 56 387712

Proteins from Pathway: Returns a list of proteins involved in a given pathway. For example, for the Reactome pathway R-HSA-70171:

result <- get_pug_rest(identifier = "Reactome:R-HSA-70171", namespace = "pwacc", domain = "pathway", operation = "accessions", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: DomainSpecific (pathway)
#>   - Namespace: DomainSpecific
#>   - Operation: accessions
#>   - Identifier: Reactome:R-HSA-70171
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>        Text
#> 1    A6NDG6
#> 2    A6NNW6
#> 3    O14556
#> 4    O15504
#> 5    O60825
#> 6    O75694
#> 7    P00558
#> 8    P04075
#> 9    P04406
#> 10   P05062
#> 11   P06733
#> 12   P06744
#> 13   P07205
#> 14   P07738
#> 15   P08237
#> 16   P09104
#> 17   P09972
#> 18   P12270
#> 19   P13929
#> 20 P14618-1
#> 21 P14618-2
#> 22   P15259
#> 23   P16118
#> 24   P17858
#> 25   P18669
#> 26   P35557
#> 27   P35658
#> 28   P37198
#> 29   P46926
#> 30   P49790
#> 31   P49792
#> 32 P52948-5
#> 33   P55735
#> 34   P57740
#> 35   P60174
#> 36   P78406
#> 37   Q01813
#> 38   Q12769
#> 39   Q14397
#> 40   Q14738
#> 41   Q16875
#> 42   Q16877
#> 43   Q5SRE5
#> 44   Q6PCE3
#> 45   Q7Z3B4
#> 46   Q8N1F7
#> 47   Q8NFH3
#> 48   Q8NFH4
#> 49   Q8NFH5
#> 50   Q8TDQ7
#> 51   Q8TEM1
#> 52   Q8WUM0
#> 53   Q92621
#> 54 Q96EE3-1
#> 55 Q96EE3-2
#> 56   Q99567
#> 57   Q9BRR6
#> 58   Q9BTX1
#> 59   Q9BW27
#> 60   Q9NRG9
#> 61   Q9UKX7

These methods offer a streamlined and efficient way to access and analyze pathway-related data in PubChem, supporting a wide range of research applications in bioinformatics, molecular biology, and related fields.

3.7. Taxonomies

PubChem’s PUG REST service provides a comprehensive approach to accessing taxonomy information, essential for researchers in fields like biology, pharmacology, and environmental science. Here’s how to utilize PUG REST for taxonomy-related queries:

1. Taxonomy Input Methods:

By Taxonomy ID: The primary method to access taxonomy data in PubChem using NCBI Taxonomy identifiers. For example, to get a summary for human (Taxonomy ID 9606) and SARS-CoV-2 (Taxonomy ID 2697049) in JSON format:

result <- get_pug_rest(identifier = "9606,2697049", namespace = "taxid", domain = "taxonomy", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Taxonomy
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: 9606,2697049
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $TaxonomySummaries
#> $TaxonomySummaries$TaxonomySummary
#> $TaxonomySummaries$TaxonomySummary[[1]]
#> $TaxonomySummaries$TaxonomySummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$ScientificName
#> [1] "Homo sapiens"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$CommonName
#> [1] "human"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$Rank
#> [1] "species"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$RankedLineage
#>      Species        Genus       Family        Order        Class       Phylum 
#>           ""       "Homo"  "Hominidae"   "Primates"   "Mammalia"   "Chordata" 
#>      Kingdom Superkingdom 
#>    "Metazoa"  "Eukaryota" 
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$Synonym
#> [1] "Homo sapiens Linnaeus, 1758" "Homo sapiens"               
#> [3] "human"                      
#> 
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]
#> $TaxonomySummaries$TaxonomySummary[[2]]$TaxonomyID
#> [1] 2697049
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$ScientificName
#> [1] "Severe acute respiratory syndrome coronavirus 2"
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$CommonName
#> [1] ""
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$Rank
#> [1] "no rank"
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$RankedLineage
#>                                                 Species 
#> "Severe acute respiratory syndrome-related coronavirus" 
#>                                                   Genus 
#>                                       "Betacoronavirus" 
#>                                                  Family 
#>                                         "Coronaviridae" 
#>                                                   Order 
#>                                           "Nidovirales" 
#>                                                   Class 
#>                                       "Pisoniviricetes" 
#>                                                  Phylum 
#>                                          "Pisuviricota" 
#>                                                 Kingdom 
#>                                         "Orthornavirae" 
#>                                            Superkingdom 
#>                                               "Viruses" 
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$Synonym
#> [1] "2019-nCoV"                                      
#> [2] "COVID-19 virus"                                 
#> [3] "HCoV-19"                                        
#> [4] "Human coronavirus 2019"                         
#> [5] "SARS-2"                                         
#> [6] "SARS2"                                          
#> [7] "SARS-CoV2"                                      
#> [8] "Severe acute respiratory syndrome coronavirus 2"

By Taxonomy Synonym: Access taxonomy data using synonyms like scientific or common names. For example, for Homo sapiens:

result <- get_pug_rest(identifier = "Homo sapiens", namespace = "synonym", domain = "taxonomy", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Taxonomy
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: Homo sapiens
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result) 
#> $TaxonomySummaries
#> $TaxonomySummaries$TaxonomySummary
#> $TaxonomySummaries$TaxonomySummary[[1]]
#> $TaxonomySummaries$TaxonomySummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$ScientificName
#> [1] "Homo sapiens"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$CommonName
#> [1] "human"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$Rank
#> [1] "species"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$RankedLineage
#>      Species        Genus       Family        Order        Class       Phylum 
#>           ""       "Homo"  "Hominidae"   "Primates"   "Mammalia"   "Chordata" 
#>      Kingdom Superkingdom 
#>    "Metazoa"  "Eukaryota" 
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$Synonym
#> [1] "Homo sapiens Linnaeus, 1758" "Homo sapiens"               
#> [3] "human"

2. Available Taxonomy Data:

Taxonomy Summary: Returns a summary including TaxonomyID, ScientificName, CommonName, Rank, RankedLineage, and Synonyms. For example:

result <- get_pug_rest(identifier = "9606,10090,10116", namespace = "taxid", domain = "taxonomy", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Taxonomy
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: 9606,10090,10116
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $TaxonomySummaries
#> $TaxonomySummaries$TaxonomySummary
#> $TaxonomySummaries$TaxonomySummary[[1]]
#> $TaxonomySummaries$TaxonomySummary[[1]]$TaxonomyID
#> [1] 9606
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$ScientificName
#> [1] "Homo sapiens"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$CommonName
#> [1] "human"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$Rank
#> [1] "species"
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$RankedLineage
#>      Species        Genus       Family        Order        Class       Phylum 
#>           ""       "Homo"  "Hominidae"   "Primates"   "Mammalia"   "Chordata" 
#>      Kingdom Superkingdom 
#>    "Metazoa"  "Eukaryota" 
#> 
#> $TaxonomySummaries$TaxonomySummary[[1]]$Synonym
#> [1] "Homo sapiens Linnaeus, 1758" "Homo sapiens"               
#> [3] "human"                      
#> 
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]
#> $TaxonomySummaries$TaxonomySummary[[2]]$TaxonomyID
#> [1] 10090
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$ScientificName
#> [1] "Mus musculus"
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$CommonName
#> [1] "house mouse"
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$Rank
#> [1] "species"
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$RankedLineage
#>      Species        Genus       Family        Order        Class       Phylum 
#>           ""        "Mus"    "Muridae"   "Rodentia"   "Mammalia"   "Chordata" 
#>      Kingdom Superkingdom 
#>    "Metazoa"  "Eukaryota" 
#> 
#> $TaxonomySummaries$TaxonomySummary[[2]]$Synonym
#> [1] "house mouse"                 "mouse"                      
#> [3] "Mus musculus Linnaeus, 1758" "Mus musculus"               
#> 
#> 
#> $TaxonomySummaries$TaxonomySummary[[3]]
#> $TaxonomySummaries$TaxonomySummary[[3]]$TaxonomyID
#> [1] 10116
#> 
#> $TaxonomySummaries$TaxonomySummary[[3]]$ScientificName
#> [1] "Rattus norvegicus"
#> 
#> $TaxonomySummaries$TaxonomySummary[[3]]$CommonName
#> [1] "Norway rat"
#> 
#> $TaxonomySummaries$TaxonomySummary[[3]]$Rank
#> [1] "species"
#> 
#> $TaxonomySummaries$TaxonomySummary[[3]]$RankedLineage
#>      Species        Genus       Family        Order        Class       Phylum 
#>           ""     "Rattus"    "Muridae"   "Rodentia"   "Mammalia"   "Chordata" 
#>      Kingdom Superkingdom 
#>    "Metazoa"  "Eukaryota" 
#> 
#> $TaxonomySummaries$TaxonomySummary[[3]]$Synonym
#> [1] "brown rat"                       "Mus norvegicus Berkenhout, 1769"
#> [3] "Mus norvegicus"                  "Norway rat"                     
#> [5] "rat"                             "rats"                           
#> [7] "Rattus norvegicus"

Assays and Bioactivities: Retrieves a list of assays (AIDs) associated with a given taxonomy. For example, for SARS-CoV-2:

result <- get_pug_rest(identifier = "2697049", namespace = "taxid", domain = "taxonomy", operation = "aids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Taxonomy
#>   - Namespace: DomainSpecific
#>   - Operation: aids
#>   - Identifier: 2697049
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result) 
#>        Text
#> 1   1409578
#> 2   1409579
#> 3   1409582
#> 4   1409585
#> 5   1409588
#> 6   1409589
#> 7   1409590
#> 8   1409594
#> 9   1409595
#> 10  1409598
#> 11  1409599
#> 12  1409602
#> 13  1409603
#> 14  1409605
#> 15  1409606
#> 16  1409607
#> 17  1409608
#> 18  1409614
#> 19  1409623
#> 20  1645758
#> 21  1645759
#> 22  1671498
#> 23  1671499
#> 24  1678482
#> 25  1682556
#> 26  1684795
#> 27  1684805
#> 28  1684808
#> 29  1684809
#> 30  1685583
#> 31  1692496
#> 32  1704258
#> 33  1717739
#> 34  1717742
#> 35  1717748
#> 36  1717755
#> 37  1717812
#> 38  1717813
#> 39  1733128
#> 40  1733183
#> 41  1750792
#> 42  1756674
#> 43  1756676
#> 44  1756677
#> 45  1756960
#> 46  1756961
#> 47  1756962
#> 48  1762039
#> 49  1762040
#> 50  1762041
#> 51  1762042
#> 52  1762043
#> 53  1762044
#> 54  1763053
#> 55  1763054
#> 56  1763571
#> 57  1763573
#> 58  1763925
#> 59  1766061
#> 60  1766062
#> 61  1766065
#> 62  1766066
#> 63  1766070
#> 64  1766122
#> 65  1766126
#> 66  1766127
#> 67  1766128
#> 68  1766129
#> 69  1766130
#> 70  1766166
#> 71  1766167
#> 72  1766168
#> 73  1767844
#> 74  1767845
#> 75  1768968
#> 76  1768969
#> 77  1774049
#> 78  1774051
#> 79  1774052
#> 80  1774053
#> 81  1774054
#> 82  1777358
#> 83  1777359
#> 84  1777360
#> 85  1777361
#> 86  1777362
#> 87  1778630
#> 88  1782697
#> 89  1783387
#> 90  1783391
#> 91  1783393
#> 92  1783396
#> 93  1783398
#> 94  1783399
#> 95  1783400
#> 96  1783420
#> 97  1783421
#> 98  1783422
#> 99  1785765
#> 100 1785767
#> 101 1785768
#> 102 1785769
#> 103 1785770
#> 104 1785771
#> 105 1785772
#> 106 1785773
#> 107 1785774
#> 108 1785775
#> 109 1785776
#> 110 1808127
#> 111 1809725
#> 112 1809727
#> 113 1809728
#> 114 1810094
#> 115 1810095
#> 116 1810096
#> 117 1810097
#> 118 1810098
#> 119 1810099
#> 120 1811315
#> 121 1811318
#> 122 1811334
#> 123 1811336
#> 124 1811337
#> 125 1812897
#> 126 1815250
#> 127 1815252
#> 128 1815257
#> 129 1815261
#> 130 1815328
#> 131 1815329
#> 132 1816643
#> 133 1816646
#> 134 1816648
#> 135 1816650
#> 136 1816677
#> 137 1816678
#> 138 1816679
#> 139 1816680
#> 140 1817679
#> 141 1817680
#> 142 1817681
#> 143 1817683
#> 144 1817714
#> 145 1817715
#> 146 1817716
#> 147 1818936
#> 148 1820302
#> 149 1820303
#> 150 1820306
#> 151 1820307
#> 152 1820344
#> 153 1820345
#> 154 1820346
#> 155 1820417
#> 156 1820419
#> 157 1820425
#> 158 1820426
#> 159 1820428
#> 160 1820429
#> 161 1820434
#> 162 1820437
#> 163 1820447
#> 164 1825216
#> 165 1825217
#> 166 1825218
#> 167 1825219
#> 168 1825220
#> 169 1832331
#> 170 1845235
#> 171 1845237
#> 172 1846469
#> 173 1846470
#> 174 1846471
#> 175 1846472
#> 176 1846473
#> 177 1846487
#> 178 1851895
#> 179 1851900
#> 180 1853884
#> 181 1853885
#> 182 1853886
#> 183 1853887
#> 184 1853888
#> 185 1853889
#> 186 1853890
#> 187 1853891
#> 188 1853892
#> 189 1853893
#> 190 1853894
#> 191 1853895
#> 192 1853896
#> 193 1853897
#> 194 1853898
#> 195 1853899
#> 196 1853900
#> 197 1854357
#> 198 1854360
#> 199 1854363
#> 200 1854437
#> 201 1856553
#> 202 1857250
#> 203 1857252
#> 204 1857253
#> 205 1857254
#> 206 1857255
#> 207 1857878
#> 208 1857879
#> 209 1857880
#> 210 1857881
#> 211 1857882
#> 212 1857884
#> 213 1857885
#> 214 1858559
#> 215 1858562
#> 216 1859992
#> 217 1859993
#> 218 1859994
#> 219 1859995
#> 220 1859998
#> 221 1860001
#> 222 1860002
#> 223 1860003
#> 224 1860004
#> 225 1860005
#> 226 1860006
#> 227 1860007
#> 228 1860008
#> 229 1860009
#> 230 1860012
#> 231 1860014
#> 232 1860015
#> 233 1860016
#> 234 1862231
#> 235 1862232
#> 236 1862233
#> 237 1862234
#> 238 1862235
#> 239 1863307
#> 240 1863308
#> 241 1863309
#> 242 1863314
#> 243 1863315
#> 244 1865408
#> 245 1865409
#> 246 1869094
#> 247 1869096
#> 248 1871176
#> 249 1871186
#> 250 1871187
#> 251 1871188
#> 252 1871195
#> 253 1871196
#> 254 1873612
#> 255 1875154
#> 256 1875161
#> 257 1875162
#> 258 1875163
#> 259 1875164
#> 260 1875166
#> 261 1875882
#> 262 1875889
#> 263 1875890
#> 264 1875896
#> 265 1875897
#> 266 1875908
#> 267 1875986
#> 268 1876053
#> 269 1876098
#> 270 1876253
#> 271 1876316
#> 272 1876321
#> 273 1876328
#> 274 1876330
#> 275 1876331
#> 276 1876332
#> 277 1877262
#> 278 1877267
#> 279 1877268
#> 280 1877269
#> 281 1877270
#> 282 1877271
#> 283 1877272
#> 284 1877273
#> 285 1877274
#> 286 1877275
#> 287 1877276
#> 288 1877277
#> 289 1878326
#> 290 1878327
#> 291 1878328
#> 292 1878329
#> 293 1878336
#> 294 1878337
#> 295 1878338
#> 296 1878353
#> 297 1878355
#> 298 1878356
#> 299 1879911
#> 300 1880205
#> 301 1880957
#> 302 1880958
#> 303 1881678
#> 304 1881681
#> 305 1881688
#> 306 1881695
#> 307 1881721
#> 308 1881729
#> 309 1881730
#> 310 1881733
#> 311 1881734
#> 312 1881735
#> 313 1881736
#> 314 1881737
#> 315 1881740
#> 316 1881741
#> 317 1881745
#> 318 1881747
#> 319 1882572
#> 320 1882573
#> 321 1882574
#> 322 1882575
#> 323 1884002
#> 324 1884004
#> 325 1884008
#> 326 1884010
#> 327 1884014
#> 328 1884019
#> 329 1884022
#> 330 1884029
#> 331 1884032
#> 332 1884044
#> 333 1884126
#> 334 1884127
#> 335 1884558
#> 336 1884560
#> 337 1884562
#> 338 1884564
#> 339 1884566
#> 340 1884568
#> 341 1884570
#> 342 1884572
#> 343 1888678
#> 344 1888679
#> 345 1888680
#> 346 1890667
#> 347 1890668
#> 348 1890669
#> 349 1890670
#> 350 1890671
#> 351 1890673
#> 352 1890674
#> 353 1890675
#> 354 1893718
#> 355 1893719
#> 356 1894685
#> 357 1895996
#> 358 1897958
#> 359 1897968
#> 360 1897970
#> 361 1897972
#> 362 1898047
#> 363 1898048
#> 364 1898049
#> 365 1898371
#> 366 1898372
#> 367 1898373
#> 368 1898386
#> 369 1898457
#> 370 1898461
#> 371 1898547
#> 372 1898748
#> 373 1898754
#> 374 1898765
#> 375 1898766
#> 376 1898773
#> 377 1898774
#> 378 1898775
#> 379 1898779
#> 380 1898782
#> 381 1898783
#> 382 1904972
#> 383 1906772
#> 384 1906784
#> 385 1906785
#> 386 1906786
#> 387 1906787
#> 388 1906788
#> 389 1906789
#> 390 1906802
#> 391 1906803
#> 392 1911673
#> 393 1911674
#> 394 1916354
#> 395 1916961
#> 396 1918729
#> 397 1918735
#> 398 1920272
#> 399 1920273
#> 400 1920276
#> 401 1922108
#> 402 1922110
#> 403 1922114
#> 404 1922118
#> 405 1922120
#> 406 1922122
#> 407 1922123
#> 408 1922125
#> 409 1922126
#> 410 1922131
#> 411 1922132
#> 412 1922133
#> 413 1922135
#> 414 1922136
#> 415 1922137
#> 416 1922139
#> 417 1922142
#> 418 1922144
#> 419 1922145
#> 420 1922147
#> 421 1922149
#> 422 1922999
#> 423 1923922
#> 424 1923923
#> 425 1923924
#> 426 1923931
#> 427 1923935
#> 428 1923952
#> 429 1926781
#> 430 1927265
#> 431 1927280
#> 432 1927286
#> 433 1928658
#> 434 1928660
#> 435 1928661
#> 436 1928667
#> 437 1928668
#> 438 1928669
#> 439 1928670
#> 440 1929028
#> 441 1929044
#> 442 1929691
#> 443 1929692
#> 444 1929693
#> 445 1931760
#> 446 1942232
#> 447 1942235
#> 448 1942239
#> 449 1942534
#> 450 1942540
#> 451 1942547
#> 452 1942556
#> 453 1942759
#> 454 1943742
#> 455 1943744
#> 456 1943746
#> 457 1943750
#> 458 1943779
#> 459 1943781
#> 460 1946884
#> 461 1946886
#> 462 1946932
#> 463 1946933
#> 464 1946937
#> 465 1946938
#> 466 1946939
#> 467 1948588
#> 468 1948591
#> 469 1951065
#> 470 1951067
#> 471 1951075
#> 472 1951104
#> 473 1951111
#> 474 1951112
#> 475 1951115
#> 476 1951510
#> 477 1951513
#> 478 1952452
#> 479 1952454
#> 480 1954264
#> 481 1954265
#> 482 1954267
#> 483 1955375
#> 484 1955377
#> 485 1955378
#> 486 1955380
#> 487 1955381
#> 488 1955384
#> 489 1955385
#> 490 1956257
#> 491 1956689
#> 492 1962013

To aggregate concise bioactivity data from each AID:

result <- get_pug_rest(identifier = "1409578", namespace = "aid", domain = "assay", operation = "concise", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: concise
#>   - Identifier: 1409578
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#>  [1] "AID"                 "SID"                 "CID"                
#>  [4] "Activity Outcome"    "Target Accession"    "Target GeneID"      
#>  [7] "Activity Value [uM]" "Activity Name"       "Assay Name"         
#> [10] "Assay Type"          "PubMed ID"           "RNAi"               
#> 
#> 
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103196897"                                                                                                                                                  
#>  [3] "11199915"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.22"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[2]]
#> $Table$Row[[2]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103224052"                                                                                                                                                  
#>  [3] "2247"                                                                                                                                                       
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.1"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[3]]
#> $Table$Row[[3]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103246927"                                                                                                                                                  
#>  [3] "208917"                                                                                                                                                     
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.1"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[4]]
#> $Table$Row[[4]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103281094"                                                                                                                                                  
#>  [3] "9801987"                                                                                                                                                    
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.75"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[5]]
#> $Table$Row[[5]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103368147"                                                                                                                                                  
#>  [3] "6476696"                                                                                                                                                    
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.25"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[6]]
#> $Table$Row[[6]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103389209"                                                                                                                                                  
#>  [3] "10316203"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.2"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[7]]
#> $Table$Row[[7]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103439840"                                                                                                                                                  
#>  [3] "73078"                                                                                                                                                      
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.1"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[8]]
#> $Table$Row[[8]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103467980"                                                                                                                                                  
#>  [3] "11591924"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.2"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[9]]
#> $Table$Row[[9]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103490076"                                                                                                                                                  
#>  [3] "15984102"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.95"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[10]]
#> $Table$Row[[10]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "103626512"                                                                                                                                                  
#>  [3] "44579921"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.6"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[11]]
#> $Table$Row[[11]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "381838043"                                                                                                                                                  
#>  [3] "121304016"                                                                                                                                                  
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.62"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[12]]
#> $Table$Row[[12]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "404718364"                                                                                                                                                  
#>  [3] "10173277"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.023"                                                                                                                                                      
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[13]]
#> $Table$Row[[13]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "405270384"                                                                                                                                                  
#>  [3] "73715817"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.19"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[14]]
#> $Table$Row[[14]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "405270481"                                                                                                                                                  
#>  [3] "3025960"                                                                                                                                                    
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "1.2"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[15]]
#> $Table$Row[[15]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "405270549"                                                                                                                                                  
#>  [3] "11527774"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.14"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[16]]
#> $Table$Row[[16]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "405270558"                                                                                                                                                  
#>  [3] "70945511"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.3"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[17]]
#> $Table$Row[[17]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "405270636"                                                                                                                                                  
#>  [3] "21476448"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.95"                                                                                                                                                       
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""                                                                                                                                                           
#> 
#> 
#> $Table$Row[[18]]
#> $Table$Row[[18]]$Cell
#>  [1] "1409578"                                                                                                                                                    
#>  [2] "405270669"                                                                                                                                                  
#>  [3] "11582982"                                                                                                                                                   
#>  [4] "Active"                                                                                                                                                     
#>  [5] ""                                                                                                                                                           
#>  [6] ""                                                                                                                                                           
#>  [7] "0.5"                                                                                                                                                        
#>  [8] "EC50"                                                                                                                                                       
#>  [9] "Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs"
#> [10] "Confirmatory"                                                                                                                                               
#> [11] ""                                                                                                                                                           
#> [12] ""

These methods offer a streamlined and efficient way to access and analyze taxonomy-related data in PubChem, supporting a wide range of research applications in biology, pharmacology, environmental science, and related fields.

3.8. Cell Lines

PubChem’s PUG REST service offers a valuable resource for accessing detailed information about various cell lines, crucial for research in cellular biology, pharmacology, and related fields. Here’s how to effectively use PUG REST for cell line-related queries:

1. Cell Line Input Methods:

By Cell Line Accession: Utilize Cellosaurus and ChEMBL cell line accessions for precise data retrieval. For example:

result <- get_pug_rest(identifier = "CHEMBL3308376,CVCL_0045", namespace = "cellacc", domain = "cell", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Cell
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: CHEMBL3308376,CVCL_0045
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $CellSummaries
#> $CellSummaries$CellSummary
#> $CellSummaries$CellSummary[[1]]
#> $CellSummaries$CellSummary[[1]]$CellAccession
#> [1] "CVCL_0030"
#> 
#> $CellSummaries$CellSummary[[1]]$Name
#> [1] "HeLa"
#> 
#> $CellSummaries$CellSummary[[1]]$Sex
#> [1] "Female"
#> 
#> $CellSummaries$CellSummary[[1]]$Category
#> [1] "Cancer cell line"
#> 
#> $CellSummaries$CellSummary[[1]]$SourceTissue
#> [1] "uterine cervix"
#> 
#> $CellSummaries$CellSummary[[1]]$SourceTaxonomyID
#> [1] 9606
#> 
#> $CellSummaries$CellSummary[[1]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#> 
#> $CellSummaries$CellSummary[[1]]$Synonym
#> [1] "HELA"                  "Hela"                  "He La"                
#> [4] "He-La"                 "HeLa-CCL2"             "Henrietta Lacks cells"
#> [7] "Helacyton gartleri"   
#> 
#> 
#> $CellSummaries$CellSummary[[2]]
#> $CellSummaries$CellSummary[[2]]$CellAccession
#> [1] "CVCL_0045"
#> 
#> $CellSummaries$CellSummary[[2]]$Name
#> [1] "HEK293"
#> 
#> $CellSummaries$CellSummary[[2]]$Sex
#> [1] "Female"
#> 
#> $CellSummaries$CellSummary[[2]]$Category
#> [1] "Transformed cell line"
#> 
#> $CellSummaries$CellSummary[[2]]$SourceTissue
#> [1] "kidney"
#> 
#> $CellSummaries$CellSummary[[2]]$SourceTaxonomyID
#> [1] 9606
#> 
#> $CellSummaries$CellSummary[[2]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#> 
#> $CellSummaries$CellSummary[[2]]$Synonym
#>  [1] "Hek293"                     "HEK-293"                   
#>  [3] "HEK/293"                    "HEK 293"                   
#>  [5] "HEK;293"                    "293"                       
#>  [7] "293 HEK"                    "293 Ad5"                   
#>  [9] "Graham 293"                 "Graham-293"                
#> [11] "Human Embryonic Kidney 293"

By Cell Line Synonym: Access data using cell line names or other synonyms. For instance, for the HeLa cell line:

result <- get_pug_rest(identifier = "HeLa", namespace = "synonym", domain = "cell", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Cell
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: HeLa
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $CellSummaries
#> $CellSummaries$CellSummary
#> $CellSummaries$CellSummary[[1]]
#> $CellSummaries$CellSummary[[1]]$CellAccession
#> [1] "CVCL_0030"
#> 
#> $CellSummaries$CellSummary[[1]]$Name
#> [1] "HeLa"
#> 
#> $CellSummaries$CellSummary[[1]]$Sex
#> [1] "Female"
#> 
#> $CellSummaries$CellSummary[[1]]$Category
#> [1] "Cancer cell line"
#> 
#> $CellSummaries$CellSummary[[1]]$SourceTissue
#> [1] "uterine cervix"
#> 
#> $CellSummaries$CellSummary[[1]]$SourceTaxonomyID
#> [1] 9606
#> 
#> $CellSummaries$CellSummary[[1]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#> 
#> $CellSummaries$CellSummary[[1]]$Synonym
#> [1] "HELA"                  "Hela"                  "He La"                
#> [4] "He-La"                 "HeLa-CCL2"             "Henrietta Lacks cells"
#> [7] "Helacyton gartleri"

2. Available Cell Line Data:

Cell Line Summary: Provides a comprehensive overview including CellAccession, Name, Sex, Category, SourceTissue, SourceTaxonomyID, SourceOrganism, and Synonyms. For example:

result <- get_pug_rest(identifier = "CVCL_0030,CVCL_0045", namespace = "cellacc", domain = "cell", operation = "summary", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Cell
#>   - Namespace: DomainSpecific
#>   - Operation: summary
#>   - Identifier: CVCL_0030,CVCL_0045
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $CellSummaries
#> $CellSummaries$CellSummary
#> $CellSummaries$CellSummary[[1]]
#> $CellSummaries$CellSummary[[1]]$CellAccession
#> [1] "CVCL_0030"
#> 
#> $CellSummaries$CellSummary[[1]]$Name
#> [1] "HeLa"
#> 
#> $CellSummaries$CellSummary[[1]]$Sex
#> [1] "Female"
#> 
#> $CellSummaries$CellSummary[[1]]$Category
#> [1] "Cancer cell line"
#> 
#> $CellSummaries$CellSummary[[1]]$SourceTissue
#> [1] "uterine cervix"
#> 
#> $CellSummaries$CellSummary[[1]]$SourceTaxonomyID
#> [1] 9606
#> 
#> $CellSummaries$CellSummary[[1]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#> 
#> $CellSummaries$CellSummary[[1]]$Synonym
#> [1] "HELA"                  "Hela"                  "He La"                
#> [4] "He-La"                 "HeLa-CCL2"             "Henrietta Lacks cells"
#> [7] "Helacyton gartleri"   
#> 
#> 
#> $CellSummaries$CellSummary[[2]]
#> $CellSummaries$CellSummary[[2]]$CellAccession
#> [1] "CVCL_0045"
#> 
#> $CellSummaries$CellSummary[[2]]$Name
#> [1] "HEK293"
#> 
#> $CellSummaries$CellSummary[[2]]$Sex
#> [1] "Female"
#> 
#> $CellSummaries$CellSummary[[2]]$Category
#> [1] "Transformed cell line"
#> 
#> $CellSummaries$CellSummary[[2]]$SourceTissue
#> [1] "kidney"
#> 
#> $CellSummaries$CellSummary[[2]]$SourceTaxonomyID
#> [1] 9606
#> 
#> $CellSummaries$CellSummary[[2]]$SourceOrganism
#> [1] "Homo sapiens (human)"
#> 
#> $CellSummaries$CellSummary[[2]]$Synonym
#>  [1] "Hek293"                     "HEK-293"                   
#>  [3] "HEK/293"                    "HEK 293"                   
#>  [5] "HEK;293"                    "293"                       
#>  [7] "293 HEK"                    "293 Ad5"                   
#>  [9] "Graham 293"                 "Graham-293"                
#> [11] "Human Embryonic Kidney 293"

Assays and Bioactivities from Cell Line: Retrieves a list of assays (AIDs) tested on a specific cell line. For example, for HeLa:

result <- get_pug_rest(identifier = "HeLa", namespace = "synonym", domain = "cell", operation = "aids", output = "TXT")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Cell
#>   - Namespace: DomainSpecific
#>   - Operation: aids
#>   - Identifier: HeLa
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#>          Text
#> 1        1259
#> 2        1302
#> 3        1374
#> 4        1665
#> 5        1898
#> 6        3506
#> 7        3507
#> 8        3517
#> 9        3518
#> 10       3523
#> 11       3793
#> 12       3798
#> 13       3811
#> 14       3840
#> 15       3852
#> 16       3853
#> 17       3861
#> 18       3865
#> 19       3866
#> 20       3867
#> 21       3868
#> 22       3897
#> 23       3898
#> 24       3899
#> 25       3901
#> 26       3909
#> 27       3934
#> 28       3939
#> 29       4235
#> 30       4236
#> 31       4263
#> 32       4264
#> 33       4265
#> 34       5668
#> 35       6205
#> 36       6208
#> 37       6510
#> 38       6533
#> 39       6534
#> 40       6535
#> 41       6536
#> 42       6537
#> 43       6542
#> 44       6544
#> 45       6547
#> 46       6550
#> 47       6551
#> 48       6552
#> 49       6553
#> 50       6558
#> 51      29738
#> 52      32842
#> 53      42620
#> 54      42621
#> 55      42622
#> 56      51103
#> 57      53964
#> 58      54327
#> 59      54482
#> 60      54483
#> 61      54487
#> 62      54504
#> 63      54505
#> 64      56801
#> 65      56802
#> 66      56804
#> 67      56809
#> 68      56871
#> 69      57063
#> 70      57136
#> 71      57384
#> 72      57385
#> 73      57387
#> 74      70186
#> 75      70354
#> 76      70505
#> 77      70661
#> 78      73604
#> 79      79740
#> 80      79741
#> 81      79743
#> 82      79744
#> 83      79746
#> 84      79747
#> 85      79748
#> 86      79749
#> 87      79750
#> 88      79752
#> 89      79753
#> 90      79754
#> 91      79755
#> 92      79756
#> 93      79757
#> 94      79759
#> 95      79760
#> 96      79761
#> 97      79885
#> 98      79886
#> 99      79887
#> 100     79888
#> 101     79889
#> 102     79890
#> 103     79891
#> 104     79892
#> 105     79893
#> 106     79894
#> 107     79895
#> 108     79896
#> 109     79897
#> 110     79898
#> 111     79899
#> 112     79900
#> 113     79901
#> 114     79902
#> 115     79903
#> 116     79904
#> 117     79905
#> 118     79906
#> 119     79907
#> 120     79908
#> 121     79909
#> 122     79910
#> 123     79911
#> 124     79912
#> 125     79913
#> 126     79914
#> 127     79915
#> 128     79916
#> 129     81365
#> 130     81366
#> 131     81367
#> 132     81368
#> 133     81369
#> 134     81370
#> 135     81375
#> 136     81376
#> 137     81377
#> 138     81887
#> 139     81888
#> 140     84636
#> 141     84637
#> 142     84638
#> 143     84639
#> 144     86317
#> 145     86318
#> 146     86319
#> 147     86320
#> 148     86321
#> 149     86322
#> 150     86323
#> 151     86324
#> 152     86325
#> 153     86326
#> 154     86327
#> 155     86328
#> 156     86329
#> 157     86330
#> 158     86331
#> 159     86332
#> 160     86333
#> 161     86334
#> 162     86335
#> 163     86336
#> 164     86337
#> 165     86338
#> 166     86339
#> 167     86340
#> 168     86341
#> 169     86342
#> 170     86343
#> 171     86344
#> 172     86345
#> 173     86346
#> 174     86347
#> 175     86348
#> 176     86349
#> 177     86350
#> 178     86351
#> 179     86352
#> 180     86353
#> 181     86354
#> 182     86355
#> 183     86356
#> 184     86357
#> 185     86481
#> 186     86482
#> 187     86483
#> 188     86484
#> 189     86485
#> 190     86486
#> 191     86487
#> 192     86488
#> 193     86489
#> 194     86490
#> 195     86491
#> 196     86492
#> 197     86493
#> 198     86494
#> 199     86495
#> 200     86496
#> 201     86497
#> 202     86498
#> 203     86499
#> 204     86500
#> 205     86501
#> 206     86502
#> 207     86503
#> 208     86504
#> 209     86505
#> 210     86506
#> 211     86507
#> 212     86508
#> 213     86509
#> 214     86510
#> 215     86511
#> 216     86512
#> 217     86513
#> 218     86514
#> 219     86515
#> 220     86516
#> 221     86517
#> 222     86518
#> 223     86519
#> 224     86520
#> 225     86521
#> 226     86522
#> 227     86523
#> 228     86524
#> 229     86525
#> 230     86648
#> 231     86649
#> 232     86650
#> 233     86651
#> 234     86652
#> 235     86653
#> 236     86654
#> 237     86655
#> 238     86656
#> 239     86657
#> 240     86658
#> 241     86659
#> 242     86660
#> 243     86661
#> 244     86662
#> 245     86663
#> 246     86664
#> 247     86665
#> 248     86666
#> 249     86667
#> 250     86668
#> 251     86669
#> 252     86670
#> 253     86671
#> 254     86672
#> 255     86673
#> 256     86674
#> 257     86675
#> 258     86676
#> 259     86677
#> 260     86678
#> 261     86679
#> 262     86680
#> 263     86681
#> 264     86682
#> 265     86683
#> 266     86684
#> 267     86685
#> 268     86686
#> 269     86687
#> 270     86688
#> 271     86689
#> 272     86799
#> 273     86800
#> 274     86801
#> 275     86802
#> 276     86803
#> 277     86804
#> 278     86805
#> 279     86806
#> 280     86807
#> 281     86808
#> 282     86809
#> 283     86810
#> 284     86811
#> 285     86812
#> 286     86813
#> 287     86814
#> 288     86815
#> 289     86816
#> 290     86817
#> 291     86818
#> 292     86819
#> 293     86820
#> 294     86821
#> 295     86822
#> 296     86823
#> 297     86824
#> 298     86825
#> 299     86826
#> 300     86827
#> 301     86828
#> 302     86829
#> 303     86830
#> 304     86831
#> 305     86832
#> 306     86833
#> 307     86834
#> 308     86835
#> 309     86836
#> 310     86837
#> 311     86838
#> 312     86839
#> 313     86840
#> 314     86841
#> 315     86842
#> 316     86843
#> 317     86844
#> 318     86969
#> 319     86970
#> 320     86971
#> 321     86972
#> 322     86973
#> 323     86974
#> 324     86975
#> 325     86976
#> 326     86977
#> 327     86978
#> 328     86979
#> 329     86980
#> 330     86981
#> 331     86982
#> 332     86983
#> 333     86984
#> 334     86985
#> 335     86986
#> 336     86987
#> 337     86988
#> 338     86989
#> 339     86990
#> 340     86991
#> 341     86992
#> 342     86993
#> 343     86994
#> 344     86995
#> 345     86996
#> 346     86997
#> 347     86998
#> 348     86999
#> 349     87000
#> 350     87001
#> 351     87002
#> 352     87003
#> 353     87004
#> 354     87005
#> 355     87006
#> 356     87007
#> 357     87008
#> 358     87009
#> 359     87010
#> 360     87011
#> 361     87125
#> 362     87126
#> 363     87127
#> 364     87128
#> 365     87129
#> 366     87130
#> 367     87131
#> 368     87132
#> 369     87133
#> 370     87134
#> 371     87135
#> 372     87136
#> 373     87137
#> 374     87138
#> 375     87139
#> 376     87140
#> 377     87141
#> 378     87142
#> 379     87143
#> 380     87144
#> 381     87145
#> 382     87146
#> 383     87147
#> 384     87148
#> 385     87149
#> 386     87150
#> 387     87151
#> 388     87152
#> 389     87153
#> 390     87154
#> 391     87155
#> 392     87156
#> 393     87157
#> 394     87158
#> 395     87159
#> 396     87160
#> 397     87161
#> 398     87162
#> 399     87163
#> 400     87164
#> 401     87165
#> 402     87166
#> 403     87281
#> 404     87282
#> 405     87283
#> 406     87284
#> 407     87285
#> 408     87286
#> 409     87287
#> 410     87288
#> 411     87289
#> 412     87290
#> 413     87291
#> 414     87292
#> 415     87293
#> 416     87294
#> 417     87295
#> 418     87296
#> 419     87297
#> 420     87298
#> 421     87299
#> 422     87300
#> 423     87301
#> 424     87303
#> 425     87304
#> 426     87305
#> 427     87306
#> 428     87307
#> 429     87308
#> 430     87309
#> 431     87310
#> 432     87311
#> 433     87312
#> 434     87313
#> 435     87314
#> 436     87315
#> 437     87316
#> 438     87317
#> 439     87318
#> 440     87434
#> 441     87435
#> 442     87436
#> 443     87437
#> 444     87438
#> 445     87439
#> 446     87440
#> 447     87441
#> 448     87442
#> 449     87443
#> 450     87444
#> 451     87445
#> 452     87446
#> 453     87447
#> 454     87448
#> 455     87449
#> 456     87450
#> 457     87451
#> 458     87452
#> 459     87453
#> 460     87454
#> 461     87455
#> 462     87456
#> 463     87457
#> 464     87458
#> 465     87459
#> 466     87460
#> 467     87461
#> 468     87462
#> 469     87463
#> 470     87464
#> 471     87465
#> 472     87466
#> 473     87467
#> 474     87468
#> 475     87469
#> 476     87470
#> 477     87471
#> 478     87472
#> 479     87473
#> 480     87474
#> 481     87475
#> 482     87565
#> 483     87566
#> 484     87567
#> 485     87568
#> 486     87569
#> 487     87570
#> 488     87571
#> 489     87572
#> 490     87573
#> 491     87574
#> 492     87575
#> 493     87576
#> 494     87577
#> 495     87578
#> 496     87579
#> 497     87580
#> 498     87581
#> 499     87582
#> 500     87583
#> 501     87584
#> 502     87585
#> 503     87586
#> 504     87587
#> 505     87588
#> 506     87589
#> 507     87590
#> 508     87591
#> 509     87592
#> 510     87593
#> 511     87594
#> 512     87595
#> 513     87596
#> 514     87597
#> 515     87598
#> 516     87599
#> 517     87600
#> 518     87602
#> 519     87603
#> 520     87604
#> 521     87605
#> 522     87606
#> 523     87607
#> 524     87608
#> 525     87609
#> 526     87610
#> 527     87611
#> 528     87612
#> 529     87613
#> 530     87614
#> 531     87615
#> 532     87636
#> 533     87717
#> 534     87718
#> 535     87719
#> 536     87720
#> 537     87721
#> 538     87722
#> 539     87723
#> 540     87724
#> 541     87725
#> 542     87726
#> 543     87727
#> 544     87728
#> 545     87729
#> 546     87730
#> 547     87731
#> 548     87732
#> 549     87733
#> 550     87734
#> 551     87735
#> 552     87736
#> 553     87737
#> 554     87738
#> 555     87739
#> 556     87740
#> 557     87741
#> 558     87742
#> 559     87743
#> 560     87744
#> 561     87745
#> 562     87746
#> 563     87747
#> 564     87748
#> 565     87749
#> 566     87750
#> 567     87751
#> 568     87752
#> 569     87753
#> 570     87754
#> 571     87755
#> 572     87756
#> 573     87757
#> 574     87758
#> 575     87759
#> 576     87760
#> 577     87761
#> 578     87762
#> 579     87763
#> 580     87769
#> 581     87770
#> 582     87771
#> 583     87772
#> 584     87773
#> 585     87774
#> 586     87775
#> 587     87776
#> 588     87777
#> 589     87778
#> 590     87779
#> 591     87780
#> 592     87781
#> 593     87782
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#> 1468   297005
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#> 1470   297238
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#> 2340   377296
#> 2341   377297
#> 2342   377298
#> 2343   377299
#> 2344   377300
#> 2345   377301
#> 2346   377302
#> 2347   377303
#> 2348   377304
#> 2349   377305
#> 2350   377306
#> 2351   377307
#> 2352   377308
#> 2353   377309
#> 2354   377310
#> 2355   377311
#> 2356   377312
#> 2357   377313
#> 2358   377314
#> 2359   377315
#> 2360   377316
#> 2361   377317
#> 2362   377318
#> 2363   377319
#> 2364   377320
#> 2365   377321
#> 2366   377322
#> 2367   377323
#> 2368   377324
#> 2369   377325
#> 2370   377326
#> 2371   377327
#> 2372   377328
#> 2373   377329
#> 2374   377330
#> 2375   377331
#> 2376   377332
#> 2377   377333
#> 2378   377334
#> 2379   377335
#> 2380   377336
#> 2381   377337
#> 2382   377338
#> 2383   377339
#> 2384   377340
#> 2385   377341
#> 2386   377342
#> 2387   377343
#> 2388   377550
#> 2389   377606
#> 2390   377622
#> 2391   377623
#> 2392   377624
#> 2393   377625
#> 2394   377626
#> 2395   378027
#> 2396   378039
#> 2397   378139
#> 2398   378140
#> 2399   378141
#> 2400   378142
#> 2401   378143
#> 2402   378181
#> 2403   378481
#> 2404   379196
#> 2405   379284
#> 2406   379439
#> 2407   379685
#> 2408   379700
#> 2409   379701
#> 2410   379702
#> 2411   379703
#> 2412   379735
#> 2413   379736
#> 2414   379820
#> 2415   379821
#> 2416   379822
#> 2417   379823
#> 2418   379845
#> 2419   379896
#> 2420   380044
#> 2421   380051
#> 2422   380114
#> 2423   380115
#> 2424   380116
#> 2425   380117
#> 2426   380118
#> 2427   380127
#> 2428   380128
#> 2429   380362
#> 2430   380470
#> 2431   380471
#> 2432   380586
#> 2433   381150
#> 2434   381477
#> 2435   381494
#> 2436   381495
#> 2437   381496
#> 2438   381497
#> 2439   381673
#> 2440   381674
#> 2441   381677
#> 2442   381678
#> 2443   381679
#> 2444   381680
#> 2445   381681
#> 2446   381682
#> 2447   381683
#> 2448   381684
#> 2449   381685
#> 2450   381686
#> 2451   381687
#> 2452   381688
#> 2453   381689
#> 2454   381690
#> 2455   381691
#> 2456   381692
#> 2457   381693
#> 2458   381694
#> 2459   381695
#> 2460   381696
#> 2461   381717
#> 2462   381718
#> 2463   381720
#> 2464   381721
#> 2465   381722
#> 2466   381723
#> 2467   381724
#> 2468   381725
#> 2469   381726
#> 2470   381738
#> 2471   381739
#> 2472   381740
#> 2473   381741
#> 2474   381742
#> 2475   381743
#> 2476   381744
#> 2477   381745
#> 2478   381746
#> 2479   381747
#> 2480   381758
#> 2481   381759
#> 2482   381760
#> 2483   381761
#> 2484   381762
#> 2485   381763
#> 2486   381764
#> 2487   381765
#> 2488   381766
#> 2489   381767
#> 2490   381778
#> 2491   381779
#> 2492   381780
#> 2493   381781
#> 2494   381782
#> 2495   381783
#> 2496   381784
#> 2497   381785
#> 2498   381786
#> 2499   381787
#> 2500   381933
#> 2501   381936
#> 2502   381985
#> 2503   382092
#> 2504   382342
#> 2505   382679
#> 2506   382680
#> 2507   382681
#> 2508   382851
#> 2509   382918
#> 2510   383028
#> 2511   383188
#> 2512   383216
#> 2513   383438
#> 2514   383506
#> 2515   383507
#> 2516   383508
#> 2517   383509
#> 2518   383795
#> 2519   383913
#> 2520   383914
#> 2521   383915
#> 2522   383916
#> 2523   383918
#> 2524   383919
#> 2525   384919
#> 2526   385103
#> 2527   385160
#> 2528   385161
#> 2529   385290
#> 2530   385291
#> 2531   385302
#> 2532   385303
#> 2533   385306
#> 2534   385307
#> 2535   385318
#> 2536   385319
#> 2537   385575
#> 2538   385576
#> 2539   385577
#> 2540   385578
#> 2541   385579
#> 2542   385580
#> 2543   385581
#> 2544   385582
#> 2545   385583
#> 2546   385689
#> 2547   385690
#> 2548   385693
#> 2549   385694
#> 2550   386306
#> 2551   386307
#> 2552   386400
#> 2553   386692
#> 2554   387073
#> 2555   387074
#> 2556   387581
#> 2557   387596
#> 2558   387597
#> 2559   387602
#> 2560   387605
#> 2561   387694
#> 2562   387748
#> 2563   387751
#> 2564   387752
#> 2565   387753
#> 2566   387754
#> 2567   387755
#> 2568   387756
#> 2569   387757
#> 2570   387848
#> 2571   387966
#> 2572   388256
#> 2573   388756
#> 2574   390237
#> 2575   390285
#> 2576   390286
#> 2577   390287
#> 2578   390289
#> 2579   390290
#> 2580   390292
#> 2581   390533
#> 2582   390534
#> 2583   390535
#> 2584   390536
#> 2585   391725
#> 2586   391726
#> 2587   391730
#> 2588   391731
#> 2589   391754
#> 2590   391758
#> 2591   391759
#> 2592   391865
#> 2593   391871
#> 2594   391883
#> 2595   392065
#> 2596   392187
#> 2597   392188
#> 2598   392305
#> 2599   392334
#> 2600   392335
#> 2601   392340
#> 2602   392341
#> 2603   392419
#> 2604   392699
#> 2605   392759
#> 2606   392760
#> 2607   392832
#> 2608   392833
#> 2609   392836
#> 2610   392837
#> 2611   392842
#> 2612   392843
#> 2613   392844
#> 2614   392845
#> 2615   392956
#> 2616   393023
#> 2617   393024
#> 2618   393149
#> 2619   393327
#> 2620   393328
#> 2621   393329
#> 2622   393331
#> 2623   393332
#> 2624   393333
#> 2625   393334
#> 2626   393335
#> 2627   393336
#> 2628   393337
#> 2629   393338
#> 2630   393778
#> 2631   393883
#> 2632   393902
#> 2633   393903
#> 2634   393904
#> 2635   393969
#> 2636   393971
#> 2637   393972
#> 2638   394305
#> 2639   394406
#> 2640   394424
#> 2641   394428
#> 2642   394430
#> 2643   394431
#> 2644   394432
#> 2645   394433
#> 2646   394434
#> 2647   394435
#> 2648   394436
#> 2649   394437
#> 2650   394438
#> 2651   394439
#> 2652   394440
#> 2653   394441
#> 2654   394442
#> 2655   394769
#> 2656   394859
#> 2657   394861
#> 2658   394862
#> 2659   394863
#> 2660   394864
#> 2661   394865
#> 2662   394866
#> 2663   394867
#> 2664   394868
#> 2665   394869
#> 2666   394870
#> 2667   394871
#> 2668   394872
#> 2669   394873
#> 2670   395461
#> 2671   395608
#> 2672   395609
#> 2673   395610
#> 2674   396239
#> 2675   396244
#> 2676   396370
#> 2677   397046
#> 2678   397651
#> 2679   397652
#> 2680   397955
#> 2681   398539
#> 2682   398661
#> 2683   399049
#> 2684   399050
#> 2685   399176
#> 2686   399903
#> 2687   400016
#> 2688   400017
#> 2689   400018
#> 2690   400019
#> 2691   400020
#> 2692   400021
#> 2693   400065
#> 2694   400350
#> 2695   400946
#> 2696   401249
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#> 2698   401550
#> 2699   401564
#> 2700   401565
#> 2701   401566
#> 2702   401567
#> 2703   401568
#> 2704   401569
#> 2705   401593
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#> 2707   401844
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#> 2710   402235
#> 2711   402266
#> 2712   402305
#> 2713   402342
#> 2714   402501
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#> 2716   402660
#> 2717   402698
#> 2718   402782
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#> 2720   402787
#> 2721   402790
#> 2722   403063
#> 2723   403327
#> 2724   403329
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#> 2726   403331
#> 2727   403686
#> 2728   403733
#> 2729   403734
#> 2730   404114
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#> 2734   405141
#> 2735   405551
#> 2736   405928
#> 2737   406460
#> 2738   406462
#> 2739   407951
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#> 2741   408258
#> 2742   408663
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#> 2744   409606
#> 2745   409608
#> 2746   409610
#> 2747   409612
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#> 2749   409615
#> 2750   409616
#> 2751   409672
#> 2752   409722
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#> 2754   410517
#> 2755   410518
#> 2756   410519
#> 2757   410521
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#> 2759   410679
#> 2760   410680
#> 2761   410681
#> 2762   410682
#> 2763   410683
#> 2764   410684
#> 2765   410685
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#> 2768   410688
#> 2769   410689
#> 2770   410690
#> 2771   410917
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#> 2773   411254
#> 2774   411256
#> 2775   411432
#> 2776   411499
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#> 2778   411590
#> 2779   411591
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#> 2781   411593
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#> 2783   411595
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#> 2785   411744
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#> 2787   411746
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#> 2789   411748
#> 2790   411749
#> 2791   411750
#> 2792   411751
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#> 2794   411753
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#> 2799   411764
#> 2800   411765
#> 2801   411766
#> 2802   411768
#> 2803   411770
#> 2804   411772
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#> 2816   414782
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#> 2840   417672
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#> 2871   420502
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#> 2875   420978
#> 2876   421187
#> 2877   421210
#> 2878   421212
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#> 2880   421214
#> 2881   421216
#> 2882   421217
#> 2883   421218
#> 2884   421224
#> 2885   421522
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#> 2887   421549
#> 2888   421550
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#> 2891   422054
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#> 2901   423636
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#> 2944   425186
#> 2945   425187
#> 2946   425188
#> 2947   425638
#> 2948   425639
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#> 2950   426069
#> 2951   426106
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#> 2954   426320
#> 2955   426413
#> 2956   426414
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#> 2958   426416
#> 2959   426417
#> 2960   426719
#> 2961   426819
#> 2962   426823
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#> 2964   426825
#> 2965   426828
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#> 2967   426911
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#> 2969   426954
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#> 2983   427969
#> 2984   427970
#> 2985   427971
#> 2986   427973
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#> 2988   427975
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#> 2990   427981
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#> 2992   428033
#> 2993   428034
#> 2994   428041
#> 2995   428043
#> 2996   428047
#> 2997   428567
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#> 3000   430067
#> 3001   430068
#> 3002   430358
#> 3003   430377
#> 3004   430742
#> 3005   430823
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#> 3007   430825
#> 3008   430826
#> 3009   430827
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#> 3011   430829
#> 3012   430909
#> 3013   430910
#> 3014   430911
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#> 3016   430913
#> 3017   430914
#> 3018   430915
#> 3019   430921
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#> 3022   430990
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#> 3024   432026
#> 3025   432066
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#> 3042   432371
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#> 3045   432375
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#> 3052   432382
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#> 3059   433290
#> 3060   433291
#> 3061   433292
#> 3062   433293
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#> 3075   434711
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#> 3079   434865
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#> 3084   436725
#> 3085   436726
#> 3086   436985
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#> 3088   437001
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#> 3093   437361
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#> 3095   438045
#> 3096   438046
#> 3097   438047
#> 3098   438216
#> 3099   438218
#> 3100   438220
#> 3101   438783
#> 3102   439709
#> 3103   441607
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#> 3105   441616
#> 3106   441617
#> 3107   441811
#> 3108   441812
#> 3109   442504
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#> 3111   443312
#> 3112   443467
#> 3113   443590
#> 3114   443591
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#> 3116   443719
#> 3117   443720
#> 3118   443721
#> 3119   443722
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#> 3121   443930
#> 3122   443931
#> 3123   443933
#> 3124   443967
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#> 3126   443969
#> 3127   444158
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#> 3129   444160
#> 3130   444165
#> 3131   444166
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#> 3133   444290
#> 3134   444894
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#> 3136   445066
#> 3137   445067
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#> 3139   445502
#> 3140   445506
#> 3141   445651
#> 3142   445855
#> 3143   445922
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#> 3145   446323
#> 3146   446324
#> 3147   446329
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#> 3149   447578
#> 3150   447579
#> 3151   447580
#> 3152   447581
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#> 3154   447583
#> 3155   447584
#> 3156   447880
#> 3157   447991
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#> 3159   448004
#> 3160   448393
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#> 3162   449217
#> 3163   449218
#> 3164   449883
#> 3165   449889
#> 3166   449979
#> 3167   449980
#> 3168   449982
#> 3169   450286
#> 3170   450295
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#> 3172   450308
#> 3173   450313
#> 3174   450675
#> 3175   450981
#> 3176   450985
#> 3177   450986
#> 3178   450993
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#> 3180   450997
#> 3181   450999
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#> 3183   451003
#> 3184   451005
#> 3185   451007
#> 3186   451009
#> 3187   451011
#> 3188   452267
#> 3189   452318
#> 3190   452325
#> 3191   452326
#> 3192   452327
#> 3193   452328
#> 3194   452329
#> 3195   452330
#> 3196   452331
#> 3197   452332
#> 3198   452333
#> 3199   452334
#> 3200   452335
#> 3201   452336
#> 3202   452337
#> 3203   452338
#> 3204   452339
#> 3205   452340
#> 3206   452341
#> 3207   452342
#> 3208   452343
#> 3209   452344
#> 3210   452345
#> 3211   452346
#> 3212   452347
#> 3213   452348
#> 3214   452349
#> 3215   452350
#> 3216   452351
#> 3217   452352
#> 3218   452353
#> 3219   452354
#> 3220   452355
#> 3221   452356
#> 3222   452357
#> 3223   452358
#> 3224   452359
#> 3225   452360
#> 3226   452361
#> 3227   452362
#> 3228   452363
#> 3229   452364
#> 3230   452403
#> 3231   452459
#> 3232   452537
#> 3233   452538
#> 3234   452539
#> 3235   452540
#> 3236   452541
#> 3237   452542
#> 3238   452543
#> 3239   452660
#> 3240   452661
#> 3241   452684
#> 3242   452774
#> 3243   453067
#> 3244   453158
#> 3245   453932
#> 3246   453933
#> 3247   453934
#> 3248   453935
#> 3249   453936
#> 3250   454765
#> 3251   454766
#> 3252   454799
#> 3253   454804
#> 3254   454809
#> 3255   454810
#> 3256   454811
#> 3257   454812
#> 3258   454813
#> 3259   454814
#> 3260   454842
#> 3261   455099
#> 3262   455100
#> 3263   455101
#> 3264   455102
#> 3265   455103
#> 3266   455104
#> 3267   455105
#> 3268   455106
#> 3269   455107
#> 3270   455108
#> 3271   455109
#> 3272   455110
#> 3273   455111
#> 3274   455112
#> 3275   455113
#> 3276   455114
#> 3277   455115
#> 3278   455142
#> 3279   455465
#> 3280   455467
#> 3281   455481
#> 3282   455482
#> 3283   455483
#> 3284   455568
#> 3285   455680
#> 3286   455681
#> 3287   455682
#> 3288   455962
#> 3289   455967
#> 3290   455991
#> 3291   456175
#> 3292   456255
#> 3293   456268
#> 3294   456667
#> 3295   456668
#> 3296   456673
#> 3297   456674
#> 3298   456675
#> 3299   456676
#> 3300   456677
#> 3301   456678
#> 3302   456795
#> 3303   456976
#> 3304   457053
#> 3305   457325
#> 3306   457781
#> 3307   457782
#> 3308   457794
#> 3309   457795
#> 3310   457949
#> 3311   457950
#> 3312   457951
#> 3313   457952
#> 3314   457954
#> 3315   458395
#> 3316   458397
#> 3317   458398
#> 3318   458883
#> 3319   459054
#> 3320   459343
#> 3321   459344
#> 3322   459821
#> 3323   459834
#> 3324   459835
#> 3325   459916
#> 3326   460046
#> 3327   460538
#> 3328   460581
#> 3329   460583
#> 3330   460585
#> 3331   460587
#> 3332   461250
#> 3333   461545
#> 3334   461637
#> 3335   461848
#> 3336   461867
#> 3337   461868
#> 3338   461869
#> 3339   461870
#> 3340   461871
#> 3341   461872
#> 3342   461873
#> 3343   461874
#> 3344   461875
#> 3345   461876
#> 3346   461877
#> 3347   461878
#> 3348   462327
#> 3349   462598
#> 3350   462600
#> 3351   462602
#> 3352   462604
#> 3353   462633
#> 3354   462635
#> 3355   462643
#> 3356   462644
#> 3357   462645
#> 3358   462646
#> 3359   462647
#> 3360   462648
#> 3361   462649
#> 3362   462650
#> 3363   462651
#> 3364   462652
#> 3365   462653
#> 3366   462654
#> 3367   462655
#> 3368   462656
#> 3369   462657
#> 3370   462658
#> 3371   462659
#> 3372   462660
#> 3373   462736
#> 3374   462744
#> 3375   462745
#> 3376   462746
#> 3377   463864
#> 3378   463865
#> 3379   463866
#> 3380   463981
#> 3381   463983
#> 3382   463988
#> 3383   464126
#> 3384   464128
#> 3385   464172
#> 3386   464175
#> 3387   464176
#> 3388   464177
#> 3389   464524
#> 3390   464526
#> 3391   464527
#> 3392   464528
#> 3393   464529
#> 3394   464530
#> 3395   464534
#> 3396   464544
#> 3397   464545
#> 3398   464546
#> 3399   464547
#> 3400   464550
#> 3401   464551
#> 3402   464552
#> 3403   464553
#> 3404   464554
#> 3405   464555
#> 3406   464556
#> 3407   464557
#> 3408   464558
#> 3409   464559
#> 3410   464598
#> 3411   465029
#> 3412   465030
#> 3413   465063
#> 3414   465068
#> 3415   465069
#> 3416   465216
#> 3417   465218
#> 3418   465220
#> 3419   465222
#> 3420   465538
#> 3421   465540
#> 3422   465541
#> 3423   465713
#> 3424   465714
#> 3425   465715
#> 3426   465716
#> 3427   465717
#> 3428   465993
#> 3429   466579
#> 3430   466905
#> 3431   466906
#> 3432   466907
#> 3433   466914
#> 3434   466916
#> 3435   467758
#> 3436   467909
#> 3437   467933
#> 3438   468049
#> 3439   468116
#> 3440   468117
#> 3441   468120
#> 3442   468134
#> 3443   468135
#> 3444   468139
#> 3445   468140
#> 3446   468174
#> 3447   468210
#> 3448   468212
#> 3449   468240
#> 3450   468370
#> 3451   468371
#> 3452   468474
#> 3453   469174
#> 3454   469187
#> 3455   469269
#> 3456   469272
#> 3457   469451
#> 3458   469452
#> 3459   469457
#> 3460   469477
#> 3461   469478
#> 3462   469808
#> 3463   469910
#> 3464   470172
#> 3465   470245
#> 3466   470446
#> 3467   470459
#> 3468   470664
#> 3469   471079
#> 3470   471085
#> 3471   471379
#> 3472   471485
#> 3473   471493
#> 3474   471494
#> 3475   471495
#> 3476   471521
#> 3477   471526
#> 3478   471527
#> 3479   471528
#> 3480   471529
#> 3481   471600
#> 3482   471601
#> 3483   471781
#> 3484   471919
#> 3485   472107
#> 3486   472334
#> 3487   472336
#> 3488   473043
#> 3489   473062
#> 3490   473063
#> 3491   473064
#> 3492   473143
#> 3493   473144
#> 3494   473145
#> 3495   473146
#> 3496   473147
#> 3497   473148
#> 3498   473208
#> 3499   473218
#> 3500   473219
#> 3501   473222
#> 3502   473227
#> 3503   473228
#> 3504   473621
#> 3505   473628
#> 3506   473629
#> 3507   473630
#> 3508   473631
#> 3509   473632
#> 3510   473633
#> 3511   473634
#> 3512   473635
#> 3513   473961
#> 3514   474055
#> 3515   474598
#> 3516   474607
#> 3517   474608
#> 3518   474611
#> 3519   474624
#> 3520   474632
#> 3521   474633
#> 3522   474634
#> 3523   474635
#> 3524   474636
#> 3525   474637
#> 3526   474638
#> 3527   474639
#> 3528   474640
#> 3529   474641
#> 3530   474642
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#> 3532   474644
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#> 3534   474646
#> 3535   475271
#> 3536   475309
#> 3537   475315
#> 3538   475316
#> 3539   475493
#> 3540   475853
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#> 3542   475860
#> 3543   475874
#> 3544   475875
#> 3545   475985
#> 3546   476560
#> 3547   476714
#> 3548   476949
#> 3549   477399
#> 3550   477401
#> 3551   477515
#> 3552   477516
#> 3553   477517
#> 3554   477525
#> 3555   477828
#> 3556   477829
#> 3557   477841
#> 3558   477849
#> 3559   477927
#> 3560   477998
#> 3561   478136
#> 3562   478141
#> 3563   478150
#> 3564   478157
#> 3565   478158
#> 3566   478159
#> 3567   478160
#> 3568   478169
#> 3569   478170
#> 3570   478171
#> 3571   478172
#> 3572   478173
#> 3573   478309
#> 3574   478330
#> 3575   478331
#> 3576   478332
#> 3577   478367
#> 3578   478368
#> 3579   478513
#> 3580   478926
#> 3581   479041
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#> 3583   479046
#> 3584   479050
#> 3585   479074
#> 3586   479075
#> 3587   479353
#> 3588   479354
#> 3589   479355
#> 3590   479357
#> 3591   479358
#> 3592   479359
#> 3593   479360
#> 3594   479361
#> 3595   479365
#> 3596   479715
#> 3597   479787
#> 3598   479908
#> 3599   479909
#> 3600   479910
#> 3601   479911
#> 3602   479991
#> 3603   479993
#> 3604   480108
#> 3605   480960
#> 3606   481145
#> 3607   481147
#> 3608   481148
#> 3609   481149
#> 3610   481150
#> 3611   481151
#> 3612   481754
#> 3613   481755
#> 3614   481758
#> 3615   481759
#> 3616   481763
#> 3617   481764
#> 3618   481765
#> 3619   481766
#> 3620   481767
#> 3621   481768
#> 3622   481769
#> 3623   481770
#> 3624   481771
#> 3625   481772
#> 3626   481773
#> 3627   481774
#> 3628   481775
#> 3629   481776
#> 3630   481777
#> 3631   481783
#> 3632   481784
#> 3633   481785
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#> 3635   481787
#> 3636   481788
#> 3637   481789
#> 3638   481790
#> 3639   481791
#> 3640   481792
#> 3641   481793
#> 3642   481794
#> 3643   481796
#> 3644   481797
#> 3645   481857
#> 3646   482108
#> 3647   482324
#> 3648   482394
#> 3649   482707
#> 3650   482708
#> 3651   482710
#> 3652   482938
#> 3653   483173
#> 3654   483623
#> 3655   483670
#> 3656   483671
#> 3657   483776
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#> 3659   484874
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#> 3661   484914
#> 3662   484915
#> 3663   485531
#> 3664   485981
#> 3665   486191
#> 3666   486598
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#> 3669   486957
#> 3670   487230
#> 3671   487711
#> 3672   487853
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#> 3674   487873
#> 3675   488523
#> 3676   488530
#> 3677   488584
#> 3678   489353
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#> 3680   489430
#> 3681   489465
#> 3682   489578
#> 3683   489617
#> 3684   489636
#> 3685   489643
#> 3686   489677
#> 3687   489678
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#> 3689   489680
#> 3690   490009
#> 3691   490017
#> 3692   490113
#> 3693   490118
#> 3694   490120
#> 3695   490453
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#> 3698   490964
#> 3699   491359
#> 3700   491360
#> 3701   491361
#> 3702   491362
#> 3703   491599
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#> 3706   492168
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#> 3709   493963
#> 3710   493964
#> 3711   493973
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#> 3713   494278
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#> 3716   494644
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#> 3718   497315
#> 3719   497323
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#> 3721   497330
#> 3722   497386
#> 3723   497387
#> 3724   497388
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#> 3726   497391
#> 3727   497402
#> 3728   497403
#> 3729   497404
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#> 3731   497406
#> 3732   497407
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#> 3734   497409
#> 3735   497410
#> 3736   497419
#> 3737   497601
#> 3738   497602
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#> 3740   497604
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#> 3743   498062
#> 3744   499264
#> 3745   499265
#> 3746   499280
#> 3747   499799
#> 3748   499801
#> 3749   499803
#> 3750   499882
#> 3751   499989
#> 3752   500344
#> 3753   500359
#> 3754   500360
#> 3755   500361
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#> 3757   500363
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#> 3759   500367
#> 3760   500368
#> 3761   500369
#> 3762   500370
#> 3763   500371
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#> 3765   500373
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#> 3767   500375
#> 3768   500376
#> 3769   500377
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#> 3771   500379
#> 3772   500380
#> 3773   500381
#> 3774   500382
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#> 3777   500385
#> 3778   500386
#> 3779   500387
#> 3780   500388
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#> 3782   500390
#> 3783   500391
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#> 3785   500393
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#> 3787   500395
#> 3788   500396
#> 3789   500397
#> 3790   500398
#> 3791   500399
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#> 3793   500401
#> 3794   500402
#> 3795   500403
#> 3796   500404
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#> 3798   500406
#> 3799   500407
#> 3800   500408
#> 3801   500409
#> 3802   500410
#> 3803   500411
#> 3804   500412
#> 3805   500413
#> 3806   500414
#> 3807   500415
#> 3808   500416
#> 3809   500417
#> 3810   500418
#> 3811   500419
#> 3812   500420
#> 3813   500421
#> 3814   500422
#> 3815   500423
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#> 3817   500425
#> 3818   500426
#> 3819   500427
#> 3820   500643
#> 3821   501211
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#> 3824   501303
#> 3825   501432
#> 3826   501465
#> 3827   501467
#> 3828   501524
#> 3829   501531
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#> 3831   501533
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#> 3834   501536
#> 3835   501537
#> 3836   501538
#> 3837   501539
#> 3838   501774
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#> 3840   501898
#> 3841   502012
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#> 3843   502354
#> 3844   502355
#> 3845   502363
#> 3846   502391
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#> 3848   502393
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#> 3850   502395
#> 3851   502461
#> 3852   502481
#> 3853   502485
#> 3854   502496
#> 3855   502497
#> 3856   502502
#> 3857   502767
#> 3858   503100
#> 3859   503101
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#> 3861   503103
#> 3862   503104
#> 3863   503105
#> 3864   503106
#> 3865   503107
#> 3866   503108
#> 3867   503115
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#> 3869   503117
#> 3870   503118
#> 3871   503119
#> 3872   503121
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#> 3874   503125
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#> 3876   503127
#> 3877   503128
#> 3878   503129
#> 3879   503130
#> 3880   503131
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#> 3882   503133
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#> 3884   503137
#> 3885   503138
#> 3886   503139
#> 3887   503140
#> 3888   503148
#> 3889   503149
#> 3890   503150
#> 3891   503153
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#> 3896   503169
#> 3897   503170
#> 3898   503171
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#> 3900   503190
#> 3901   503191
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#> 3903   503195
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#> 3905   503797
#> 3906   503814
#> 3907   503961
#> 3908   503963
#> 3909   503964
#> 3910   503965
#> 3911   503979
#> 3912   503996
#> 3913   504013
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#> 3915   504287
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#> 3917   504942
#> 3918   504944
#> 3919   506526
#> 3920   506527
#> 3921   506528
#> 3922   506529
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#> 3925   506766
#> 3926   506767
#> 3927   506768
#> 3928   506771
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#> 3930   506774
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#> 3940   506789
#> 3941   506841
#> 3942   507025
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#> 3944   507027
#> 3945   507101
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#> 3952   507108
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#> 3954   507110
#> 3955   507111
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#> 3959   507213
#> 3960   507775
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#> 3963   507778
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#> 3965   508229
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#> 3967   510330
#> 3968   510348
#> 3969   510349
#> 3970   510364
#> 3971   510380
#> 3972   510391
#> 3973   510402
#> 3974   510403
#> 3975   510560
#> 3976   510611
#> 3977   510613
#> 3978   510614
#> 3979   510628
#> 3980   510632
#> 3981   510639
#> 3982   510837
#> 3983   511062
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#> 3985   511069
#> 3986   511219
#> 3987   511226
#> 3988   511339
#> 3989   511340
#> 3990   511341
#> 3991   511342
#> 3992   511343
#> 3993   511344
#> 3994   511345
#> 3995   511349
#> 3996   511350
#> 3997   511351
#> 3998   511352
#> 3999   511353
#> 4000   511354
#> 4001   511355
#> 4002   511356
#> 4003   511357
#> 4004   511358
#> 4005   511359
#> 4006   511360
#> 4007   511501
#> 4008   511502
#> 4009   511507
#> 4010   511516
#> 4011   511517
#> 4012   511518
#> 4013   511519
#> 4014   511520
#> 4015   511521
#> 4016   511522
#> 4017   513181
#> 4018   513192
#> 4019   513248
#> 4020   513662
#> 4021   513663
#> 4022   513664
#> 4023   513897
#> 4024   514080
#> 4025   514370
#> 4026   514382
#> 4027   514389
#> 4028   514390
#> 4029   515289
#> 4030   515519
#> 4031   515521
#> 4032   515616
#> 4033   515845
#> 4034   516377
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#> 4036   516379
#> 4037   516380
#> 4038   516587
#> 4039   516806
#> 4040   516807
#> 4041   516810
#> 4042   516811
#> 4043   517676
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#> 4894   617082
#> 4895   617099
#> 4896   617277
#> 4897   617316
#> 4898   617367
#> 4899   617370
#> 4900   617372
#> 4901   617374
#> 4902   617376
#> 4903   617378
#> 4904   617380
#> 4905   617383
#> 4906   617545
#> 4907   617546
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#> 4909   617548
#> 4910   617549
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#> 4912   617551
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#> 4917   617633
#> 4918   617634
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#> 4920   617636
#> 4921   617637
#> 4922   617638
#> 4923   617639
#> 4924   617931
#> 4925   618435
#> 4926   618436
#> 4927   618444
#> 4928   618833
#> 4929   618836
#> 4930   618940
#> 4931   618949
#> 4932   618951
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#> 4934   619062
#> 4935   619065
#> 4936   619079
#> 4937   619081
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#> 4939   619083
#> 4940   619188
#> 4941   619194
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#> 4943   620716
#> 4944   620718
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#> 4947   620721
#> 4948   620722
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#> 4950   620724
#> 4951   620775
#> 4952   620776
#> 4953   622250
#> 4954   622254
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#> 4956   622587
#> 4957   622588
#> 4958   622589
#> 4959   622880
#> 4960   623032
#> 4961   623527
#> 4962   623528
#> 4963   625221
#> 4964   625632
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#> 4981   626364
#> 4982   626370
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#> 4990   626446
#> 4991   626449
#> 4992   626450
#> 4993   626451
#> 4994   626453
#> 4995   626456
#> 4996   626562
#> 4997   626563
#> 4998   626564
#> 4999   626565
#> 5000   626599
#> 5001   626808
#> 5002   626809
#> 5003   626812
#> 5004   626813
#> 5005   627321
#> 5006   627322
#> 5007   627323
#> 5008   627333
#> 5009   627543
#> 5010   628210
#> 5011   628211
#> 5012   628286
#> 5013   629472
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#> 5015   629598
#> 5016   629657
#> 5017   629658
#> 5018   629659
#> 5019   629660
#> 5020   629661
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#> 5025   629666
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#> 5027   629668
#> 5028   629669
#> 5029   629670
#> 5030   629671
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#> 5032   629673
#> 5033   629674
#> 5034   629675
#> 5035   629676
#> 5036   629677
#> 5037   629678
#> 5038   629679
#> 5039   630394
#> 5040   631064
#> 5041   631065
#> 5042   631066
#> 5043   631067
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#> 5045   631069
#> 5046   631070
#> 5047   632460
#> 5048   632958
#> 5049   632959
#> 5050   632960
#> 5051   632961
#> 5052   632962
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#> 5054   633104
#> 5055   633360
#> 5056   633549
#> 5057   633790
#> 5058   633793
#> 5059   633826
#> 5060   634027
#> 5061   634247
#> 5062   634248
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#> 5076   634332
#> 5077   634333
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#> 5087   634760
#> 5088   634761
#> 5089   634800
#> 5090   634831
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#> 5093   635152
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#> 5099   635410
#> 5100   635458
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#> 5102   635970
#> 5103   635971
#> 5104   636045
#> 5105   636743
#> 5106   636803
#> 5107   636820
#> 5108   636890
#> 5109   636893
#> 5110   636972
#> 5111   637107
#> 5112   637753
#> 5113   637754
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#> 5115   638252
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#> 5117   638259
#> 5118   638260
#> 5119   638261
#> 5120   638262
#> 5121   638263
#> 5122   638664
#> 5123   638665
#> 5124   638846
#> 5125   638847
#> 5126   638848
#> 5127   638849
#> 5128   638850
#> 5129   638851
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#> 5131   638853
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#> 5133   638907
#> 5134   638908
#> 5135   639125
#> 5136   639129
#> 5137   639130
#> 5138   639210
#> 5139   639802
#> 5140   639973
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#> 5142   640295
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#> 5144   640300
#> 5145   640301
#> 5146   640938
#> 5147   641317
#> 5148   642050
#> 5149   642054
#> 5150   642096
#> 5151   642097
#> 5152   642106
#> 5153   642107
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#> 5156   642110
#> 5157   642111
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#> 5159   642113
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#> 5161   642194
#> 5162   642312
#> 5163   642325
#> 5164   642327
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#> 5166   642381
#> 5167   642384
#> 5168   642962
#> 5169   643008
#> 5170   643012
#> 5171   643013
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#> 5173   643173
#> 5174   643200
#> 5175   643526
#> 5176   643542
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#> 5185   643611
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#> 5188   643614
#> 5189   643615
#> 5190   643616
#> 5191   643617
#> 5192   643618
#> 5193   643619
#> 5194   643620
#> 5195   643621
#> 5196   643622
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#> 5198   643624
#> 5199   643625
#> 5200   643626
#> 5201   643627
#> 5202   643628
#> 5203   643632
#> 5204   644044
#> 5205   644047
#> 5206   644081
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#> 5208   644100
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#> 5210   644286
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#> 5231   647318
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#> 5235   648287
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#> 5253   649764
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#> 5265   649929
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#> 5300   649966
#> 5301   650775
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#> 5303   651864
#> 5304   652709
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#> 5320   652762
#> 5321   652763
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#> 5323   653006
#> 5324   653130
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#> 5327   653269
#> 5328   653298
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#> 5330   653534
#> 5331   653535
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#> 5333   653673
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#> 5335   654374
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#> 5339   654658
#> 5340   654771
#> 5341   654772
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#> 5344   654775
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#> 5346   655140
#> 5347   655141
#> 5348   655444
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#> 5364   657287
#> 5365   657288
#> 5366   657512
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#> 5369   657620
#> 5370   657621
#> 5371   657622
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#> 5373   657624
#> 5374   657625
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#> 5376   657708
#> 5377   657709
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#> 5379   658742
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#> 5381   658744
#> 5382   658745
#> 5383   658754
#> 5384   658920
#> 5385   658921
#> 5386   658922
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#> 5388   659042
#> 5389   659043
#> 5390   659044
#> 5391   659045
#> 5392   659046
#> 5393   659047
#> 5394   659048
#> 5395   659049
#> 5396   659140
#> 5397   659151
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#> 5399   659153
#> 5400   659197
#> 5401   659199
#> 5402   659200
#> 5403   659201
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#> 5405   659216
#> 5406   659217
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#> 5408   659289
#> 5409   659293
#> 5410   659405
#> 5411   659492
#> 5412   659493
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#> 5415   659628
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#> 5420   660120
#> 5421   660814
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#> 5425   660818
#> 5426   660820
#> 5427   660822
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#> 5429   660825
#> 5430   660829
#> 5431   661616
#> 5432   661617
#> 5433   661618
#> 5434   661619
#> 5435   662342
#> 5436   663331
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#> 5439   664315
#> 5440   664434
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#> 5452   665010
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#> 5470   665588
#> 5471   666611
#> 5472   666616
#> 5473   666617
#> 5474   666618
#> 5475   666623
#> 5476   666624
#> 5477   666625
#> 5478   666740
#> 5479   667183
#> 5480   667297
#> 5481   667382
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#> 5484   667431
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#> 5486   667541
#> 5487   667626
#> 5488   667667
#> 5489   667668
#> 5490   668822
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#> 5492   668824
#> 5493   668825
#> 5494   669155
#> 5495   669491
#> 5496   669495
#> 5497   669508
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#> 5499   669514
#> 5500   669515
#> 5501   669516
#> 5502   669517
#> 5503   669538
#> 5504   669756
#> 5505   670436
#> 5506   670486
#> 5507   670505
#> 5508   670514
#> 5509   670601
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#> 5512   670611
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#> 5553   671208
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#> 5568   672228
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#> 5604   674000
#> 5605   674208
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#> 5648   675990
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#> 5653   676994
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#> 5673   678869
#> 5674   678988
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#> 5676   679001
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#> 5678   679118
#> 5679   679151
#> 5680   679154
#> 5681   679191
#> 5682   679318
#> 5683   679321
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#> 5689   679394
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#> 5692   679481
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#> 5694   679528
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#> 5896   683000
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#> 9875  1319401
#> 9876  1320554
#> 9877  1320555
#> 9878  1320556
#> 9879  1320951
#> 9880  1320983
#> 9881  1321024
#> 9882  1321516
#> 9883  1321619
#> 9884  1322187
#> 9885  1322192
#> 9886  1322193
#> 9887  1322665
#> 9888  1322669
#> 9889  1322672
#> 9890  1322673
#> 9891  1322674
#> 9892  1322675
#> 9893  1322679
#> 9894  1322680
#> 9895  1322681
#> 9896  1322682
#> 9897  1323194
#> 9898  1323224
#> 9899  1323226
#> 9900  1323272
#> 9901  1323394
#> 9902  1323437
#> 9903  1324282
#> 9904  1324283
#> 9905  1324290
#> 9906  1324332
#> 9907  1324367
#> 9908  1324383
#> 9909  1324673
#> 9910  1324674
#> 9911  1324677
#> 9912  1324691
#> 9913  1324692
#> 9914  1324693
#> 9915  1324694
#> 9916  1324839
#> 9917  1325174
#> 9918  1325185
#> 9919  1325324
#> 9920  1325327
#> 9921  1326446
#> 9922  1326613
#> 9923  1326628
#> 9924  1326761
#> 9925  1326771
#> 9926  1326772
#> 9927  1326773
#> 9928  1326776
#> 9929  1326777
#> 9930  1326778
#> 9931  1326779
#> 9932  1326780
#> 9933  1326781
#> 9934  1326782
#> 9935  1326783
#> 9936  1326784
#> 9937  1326785
#> 9938  1326786
#> 9939  1326787
#> 9940  1326788
#> 9941  1326789
#> 9942  1326790
#> 9943  1326791
#> 9944  1326792
#> 9945  1326793
#> 9946  1326794
#> 9947  1326795
#> 9948  1326797
#> 9949  1326808
#> 9950  1326916
#> 9951  1326923
#> 9952  1327256
#> 9953  1327611
#> 9954  1327943
#> 9955  1327944
#> 9956  1327945
#> 9957  1327951
#> 9958  1327986
#> 9959  1328113
#> 9960  1328345
#> 9961  1328352
#> 9962  1328758
#> 9963  1328759
#> 9964  1328894
#> 9965  1328896
#> 9966  1329678
#> 9967  1329761
#> 9968  1329765
#> 9969  1329766
#> 9970  1329767
#> 9971  1329768
#> 9972  1329769
#> 9973  1329770
#> 9974  1329771
#> 9975  1329772
#> 9976  1329773
#> 9977  1330207
#> 9978  1330282
#> 9979  1330679
#> 9980  1330717
#> 9981  1330743
#> 9982  1330942
#> 9983  1331138
#> 9984  1331139
#> 9985  1331140
#> 9986  1331141
#> 9987  1331146
#> 9988  1331147
#> 9989  1331195
#> 9990  1331196
#> 9991  1331683
#> 9992  1331866
#> 9993  1331921
#> 9994  1332066
#> 9995  1332137
#> 9996  1332221
#> 9997  1332222
#> 9998  1332272
#> 9999  1332469
#> 10000 1332474
#> 10001 1332889
#> 10002 1332890
#> 10003 1332891
#> 10004 1333345
#> 10005 1333369
#> 10006 1333401
#> 10007 1333403
#> 10008 1333404
#> 10009 1333405
#> 10010 1333406
#> 10011 1333407
#> 10012 1333408
#> 10013 1333409
#> 10014 1333410
#> 10015 1333411
#> 10016 1333412
#> 10017 1333413
#> 10018 1333414
#> 10019 1333415
#> 10020 1333416
#> 10021 1333417
#> 10022 1333418
#> 10023 1333419
#> 10024 1333783
#> 10025 1333789
#> 10026 1333796
#> 10027 1333797
#> 10028 1333798
#> 10029 1333799
#> 10030 1333800
#> 10031 1333801
#> 10032 1333802
#> 10033 1333803
#> 10034 1333804
#> 10035 1333805
#> 10036 1333875
#> 10037 1334988
#> 10038 1335229
#> 10039 1335252
#> 10040 1335253
#> 10041 1335339
#> 10042 1335572
#> 10043 1335671
#> 10044 1335715
#> 10045 1335740
#> 10046 1335741
#> 10047 1335742
#> 10048 1336104
#> 10049 1336107
#> 10050 1336614
#> 10051 1336625
#> 10052 1336748
#> 10053 1336929
#> 10054 1336946
#> 10055 1337043
#> 10056 1337044
#> 10057 1337331
#> 10058 1337335
#> 10059 1337476
#> 10060 1337672
#> 10061 1337694
#> 10062 1337704
#> 10063 1337860
#> 10064 1337861
#> 10065 1337872
#> 10066 1337873
#> 10067 1337875
#> 10068 1337884
#> 10069 1337885
#> 10070 1337886
#> 10071 1337887
#> 10072 1338079
#> 10073 1338408
#> 10074 1338410
#> 10075 1338420
#> 10076 1338424
#> 10077 1338425
#> 10078 1338426
#> 10079 1338429
#> 10080 1338430
#> 10081 1338431
#> 10082 1338432
#> 10083 1338433
#> 10084 1338434
#> 10085 1338435
#> 10086 1338436
#> 10087 1338437
#> 10088 1338438
#> 10089 1338439
#> 10090 1338505
#> 10091 1338506
#> 10092 1338512
#> 10093 1338515
#> 10094 1338516
#> 10095 1338517
#> 10096 1338518
#> 10097 1338536
#> 10098 1339746
#> 10099 1339748
#> 10100 1339749
#> 10101 1339750
#> 10102 1339751
#> 10103 1339796
#> 10104 1340386
#> 10105 1340484
#> 10106 1340485
#> 10107 1340486
#> 10108 1340600
#> 10109 1340607
#> 10110 1340608
#> 10111 1340609
#> 10112 1340797
#> 10113 1340798
#> 10114 1340799
#> 10115 1340800
#> 10116 1340801
#> 10117 1340803
#> 10118 1341033
#> 10119 1341034
#> 10120 1341035
#> 10121 1341222
#> 10122 1341223
#> 10123 1341224
#> 10124 1341225
#> 10125 1341226
#> 10126 1341227
#> 10127 1341854
#> 10128 1341855
#> 10129 1341856
#> 10130 1342578
#> 10131 1347605
#> 10132 1347686
#> 10133 1347691
#> 10134 1347717
#> 10135 1347948
#> 10136 1347989
#> 10137 1348020
#> 10138 1348283
#> 10139 1348296
#> 10140 1348297
#> 10141 1348298
#> 10142 1348299
#> 10143 1348300
#> 10144 1348302
#> 10145 1348304
#> 10146 1348305
#> 10147 1348306
#> 10148 1348307
#> 10149 1348308
#> 10150 1348309
#> 10151 1348678
#> 10152 1348796
#> 10153 1348858
#> 10154 1349059
#> 10155 1349060
#> 10156 1349922
#> 10157 1351371
#> 10158 1351509
#> 10159 1351553
#> 10160 1351590
#> 10161 1351597
#> 10162 1351601
#> 10163 1351625
#> 10164 1351630
#> 10165 1351636
#> 10166 1351642
#> 10167 1351648
#> 10168 1351722
#> 10169 1352042
#> 10170 1352048
#> 10171 1352049
#> 10172 1352050
#> 10173 1352051
#> 10174 1352052
#> 10175 1352053
#> 10176 1352054
#> 10177 1352055
#> 10178 1352056
#> 10179 1352057
#> 10180 1352058
#> 10181 1352102
#> 10182 1352354
#> 10183 1352791
#> 10184 1352854
#> 10185 1353321
#> 10186 1353602
#> 10187 1353607
#> 10188 1353631
#> 10189 1353903
#> 10190 1353904
#> 10191 1353907
#> 10192 1353908
#> 10193 1353914
#> 10194 1353915
#> 10195 1353916
#> 10196 1353917
#> 10197 1353918
#> 10198 1353919
#> 10199 1353920
#> 10200 1353922
#> 10201 1353923
#> 10202 1353926
#> 10203 1353932
#> 10204 1353933
#> 10205 1353934
#> 10206 1353935
#> 10207 1353936
#> 10208 1353937
#> 10209 1353938
#> 10210 1353939
#> 10211 1353940
#> 10212 1353941
#> 10213 1353942
#> 10214 1353943
#> 10215 1353944
#> 10216 1353945
#> 10217 1353946
#> 10218 1353947
#> 10219 1353948
#> 10220 1353949
#> 10221 1353950
#> 10222 1354765
#> 10223 1354808
#> 10224 1355086
#> 10225 1355122
#> 10226 1355749
#> 10227 1355753
#> 10228 1356527
#> 10229 1357153
#> 10230 1357525
#> 10231 1358237
#> 10232 1358238
#> 10233 1359153
#> 10234 1359157
#> 10235 1359162
#> 10236 1359163
#> 10237 1359166
#> 10238 1359167
#> 10239 1359168
#> 10240 1359169
#> 10241 1359170
#> 10242 1359458
#> 10243 1359775
#> 10244 1360199
#> 10245 1360407
#> 10246 1360488
#> 10247 1360491
#> 10248 1360492
#> 10249 1360493
#> 10250 1360494
#> 10251 1360519
#> 10252 1360520
#> 10253 1360701
#> 10254 1360878
#> 10255 1360894
#> 10256 1361024
#> 10257 1361032
#> 10258 1361034
#> 10259 1361052
#> 10260 1362219
#> 10261 1362220
#> 10262 1362221
#> 10263 1362222
#> 10264 1362223
#> 10265 1362224
#> 10266 1362225
#> 10267 1362226
#> 10268 1362227
#> 10269 1362236
#> 10270 1362238
#> 10271 1362239
#> 10272 1362240
#> 10273 1362595
#> 10274 1362924
#> 10275 1363195
#> 10276 1364316
#> 10277 1364641
#> 10278 1364647
#> 10279 1364648
#> 10280 1364649
#> 10281 1364866
#> 10282 1364867
#> 10283 1364868
#> 10284 1364869
#> 10285 1364870
#> 10286 1364871
#> 10287 1364872
#> 10288 1364873
#> 10289 1364874
#> 10290 1364875
#> 10291 1364876
#> 10292 1364877
#> 10293 1364878
#> 10294 1364879
#> 10295 1364880
#> 10296 1364881
#> 10297 1364882
#> 10298 1364883
#> 10299 1364884
#> 10300 1364885
#> 10301 1364886
#> 10302 1364887
#> 10303 1364888
#> 10304 1364889
#> 10305 1364890
#> 10306 1364891
#> 10307 1364892
#> 10308 1364893
#> 10309 1364894
#> 10310 1364895
#> 10311 1364896
#> 10312 1364897
#> 10313 1364898
#> 10314 1364899
#> 10315 1365175
#> 10316 1365617
#> 10317 1366709
#> 10318 1366860
#> 10319 1367200
#> 10320 1367219
#> 10321 1367220
#> 10322 1367600
#> 10323 1367971
#> 10324 1367972
#> 10325 1367983
#> 10326 1367984
#> 10327 1367985
#> 10328 1367986
#> 10329 1367987
#> 10330 1367988
#> 10331 1367989
#> 10332 1367990
#> 10333 1367991
#> 10334 1367992
#> 10335 1367993
#> 10336 1367994
#> 10337 1367995
#> 10338 1367996
#> 10339 1367997
#> 10340 1367998
#> 10341 1368004
#> 10342 1368005
#> 10343 1368088
#> 10344 1368237
#> 10345 1368238
#> 10346 1368239
#> 10347 1368240
#> 10348 1368241
#> 10349 1368242
#> 10350 1368243
#> 10351 1368244
#> 10352 1368245
#> 10353 1368246
#> 10354 1368247
#> 10355 1368248
#> 10356 1368259
#> 10357 1368262
#> 10358 1368263
#> 10359 1368264
#> 10360 1368265
#> 10361 1368910
#> 10362 1369036
#> 10363 1369037
#> 10364 1369038
#> 10365 1369039
#> 10366 1369048
#> 10367 1369290
#> 10368 1370138
#> 10369 1370140
#> 10370 1370142
#> 10371 1370144
#> 10372 1370146
#> 10373 1370150
#> 10374 1370151
#> 10375 1370152
#> 10376 1370154
#> 10377 1370156
#> 10378 1370158
#> 10379 1370160
#> 10380 1370162
#> 10381 1370164
#> 10382 1370165
#> 10383 1370174
#> 10384 1370443
#> 10385 1370608
#> 10386 1370809
#> 10387 1370848
#> 10388 1371027
#> 10389 1371331
#> 10390 1371473
#> 10391 1372078
#> 10392 1372079
#> 10393 1372081
#> 10394 1372082
#> 10395 1372138
#> 10396 1372139
#> 10397 1372733
#> 10398 1372736
#> 10399 1372742
#> 10400 1373379
#> 10401 1373393
#> 10402 1373394
#> 10403 1373395
#> 10404 1373396
#> 10405 1373397
#> 10406 1373398
#> 10407 1373399
#> 10408 1373400
#> 10409 1373401
#> 10410 1373402
#> 10411 1374019
#> 10412 1374020
#> 10413 1374097
#> 10414 1374232
#> 10415 1374370
#> 10416 1374856
#> 10417 1374948
#> 10418 1375725
#> 10419 1376923
#> 10420 1376932
#> 10421 1376989
#> 10422 1377013
#> 10423 1377079
#> 10424 1377086
#> 10425 1377167
#> 10426 1377480
#> 10427 1377489
#> 10428 1377490
#> 10429 1377508
#> 10430 1378248
#> 10431 1378386
#> 10432 1378391
#> 10433 1378396
#> 10434 1378403
#> 10435 1378409
#> 10436 1378623
#> 10437 1378627
#> 10438 1378645
#> 10439 1379253
#> 10440 1379254
#> 10441 1379255
#> 10442 1379256
#> 10443 1379257
#> 10444 1379650
#> 10445 1379651
#> 10446 1379661
#> 10447 1379663
#> 10448 1379664
#> 10449 1379665
#> 10450 1379666
#> 10451 1379667
#> 10452 1379668
#> 10453 1379669
#> 10454 1379670
#> 10455 1379671
#> 10456 1379672
#> 10457 1379673
#> 10458 1379674
#> 10459 1379675
#> 10460 1379676
#> 10461 1379677
#> 10462 1379678
#> 10463 1379679
#> 10464 1379680
#> 10465 1379681
#> 10466 1379682
#> 10467 1379683
#> 10468 1379684
#> 10469 1379685
#> 10470 1379686
#> 10471 1379687
#> 10472 1379688
#> 10473 1379689
#> 10474 1379690
#> 10475 1379691
#> 10476 1379692
#> 10477 1379693
#> 10478 1379817
#> 10479 1379947
#> 10480 1379948
#> 10481 1379969
#> 10482 1379995
#> 10483 1380399
#> 10484 1380404
#> 10485 1380405
#> 10486 1380406
#> 10487 1380407
#> 10488 1380408
#> 10489 1380409
#> 10490 1380410
#> 10491 1380411
#> 10492 1380412
#> 10493 1380413
#> 10494 1380414
#> 10495 1380415
#> 10496 1380416
#> 10497 1380417
#> 10498 1380418
#> 10499 1380419
#> 10500 1380420
#> 10501 1380421
#> 10502 1380422
#> 10503 1380423
#> 10504 1380424
#> 10505 1380425
#> 10506 1380426
#> 10507 1380427
#> 10508 1380428
#> 10509 1380429
#> 10510 1380430
#> 10511 1380431
#> 10512 1380432
#> 10513 1380433
#> 10514 1380434
#> 10515 1380435
#> 10516 1380436
#> 10517 1380437
#> 10518 1380438
#> 10519 1380439
#> 10520 1380440
#> 10521 1380441
#> 10522 1380442
#> 10523 1380443
#> 10524 1380444
#> 10525 1380445
#> 10526 1380446
#> 10527 1380447
#> 10528 1380943
#> 10529 1380997
#> 10530 1381047
#> 10531 1381048
#> 10532 1381049
#> 10533 1381077
#> 10534 1381079
#> 10535 1381080
#> 10536 1381081
#> 10537 1381082
#> 10538 1381083
#> 10539 1381084
#> 10540 1381085
#> 10541 1381086
#> 10542 1381087
#> 10543 1381563
#> 10544 1381567
#> 10545 1381570
#> 10546 1381572
#> 10547 1381573
#> 10548 1381574
#> 10549 1381575
#> 10550 1381576
#> 10551 1381577
#> 10552 1381578
#> 10553 1381579
#> 10554 1381580
#> 10555 1381581
#> 10556 1381582
#> 10557 1381583
#> 10558 1381973
#> 10559 1382316
#> 10560 1382444
#> 10561 1382446
#> 10562 1382639
#> 10563 1382776
#> 10564 1382780
#> 10565 1382783
#> 10566 1383307
#> 10567 1383993
#> 10568 1384133
#> 10569 1384259
#> 10570 1384646
#> 10571 1384652
#> 10572 1385098
#> 10573 1385099
#> 10574 1385454
#> 10575 1385700
#> 10576 1386263
#> 10577 1386264
#> 10578 1386265
#> 10579 1386266
#> 10580 1386517
#> 10581 1386519
#> 10582 1386590
#> 10583 1387100
#> 10584 1387378
#> 10585 1387381
#> 10586 1388158
#> 10587 1388168
#> 10588 1388178
#> 10589 1388321
#> 10590 1388322
#> 10591 1388523
#> 10592 1388624
#> 10593 1388625
#> 10594 1388626
#> 10595 1388627
#> 10596 1388628
#> 10597 1388631
#> 10598 1388632
#> 10599 1388633
#> 10600 1388634
#> 10601 1388635
#> 10602 1388637
#> 10603 1388638
#> 10604 1388640
#> 10605 1388641
#> 10606 1388900
#> 10607 1389352
#> 10608 1389357
#> 10609 1390003
#> 10610 1390004
#> 10611 1390025
#> 10612 1390092
#> 10613 1390170
#> 10614 1390171
#> 10615 1390172
#> 10616 1390181
#> 10617 1390184
#> 10618 1390185
#> 10619 1390186
#> 10620 1390189
#> 10621 1390190
#> 10622 1390191
#> 10623 1390195
#> 10624 1390197
#> 10625 1390219
#> 10626 1390384
#> 10627 1391248
#> 10628 1391396
#> 10629 1391397
#> 10630 1391668
#> 10631 1392068
#> 10632 1392077
#> 10633 1392078
#> 10634 1392309
#> 10635 1392487
#> 10636 1392517
#> 10637 1392528
#> 10638 1392529
#> 10639 1392530
#> 10640 1392531
#> 10641 1392532
#> 10642 1392533
#> 10643 1392534
#> 10644 1392535
#> 10645 1392536
#> 10646 1392537
#> 10647 1392538
#> 10648 1392539
#> 10649 1392540
#> 10650 1392541
#> 10651 1392558
#> 10652 1393882
#> 10653 1393885
#> 10654 1393888
#> 10655 1393889
#> 10656 1393890
#> 10657 1393897
#> 10658 1393898
#> 10659 1393903
#> 10660 1393906
#> 10661 1394672
#> 10662 1394768
#> 10663 1395051
#> 10664 1395532
#> 10665 1395977
#> 10666 1397252
#> 10667 1397261
#> 10668 1397548
#> 10669 1398042
#> 10670 1398044
#> 10671 1398045
#> 10672 1398046
#> 10673 1398047
#> 10674 1398048
#> 10675 1398049
#> 10676 1398050
#> 10677 1398051
#> 10678 1398052
#> 10679 1398053
#> 10680 1398054
#> 10681 1398055
#> 10682 1398056
#> 10683 1398057
#> 10684 1398058
#> 10685 1398059
#> 10686 1398060
#> 10687 1398061
#> 10688 1398062
#> 10689 1398063
#> 10690 1398064
#> 10691 1398065
#> 10692 1398066
#> 10693 1398067
#> 10694 1398068
#> 10695 1398069
#> 10696 1398070
#> 10697 1398071
#> 10698 1398072
#> 10699 1398073
#> 10700 1398074
#> 10701 1398075
#> 10702 1398076
#> 10703 1398077
#> 10704 1398078
#> 10705 1398079
#> 10706 1398080
#> 10707 1398081
#> 10708 1398082
#> 10709 1398083
#> 10710 1398084
#> 10711 1398085
#> 10712 1398086
#> 10713 1398087
#> 10714 1398088
#> 10715 1398089
#> 10716 1398090
#> 10717 1398091
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#> 10719 1398093
#> 10720 1398094
#> 10721 1398506
#> 10722 1398507
#> 10723 1398508
#> 10724 1398515
#> 10725 1398516
#> 10726 1398547
#> 10727 1399019
#> 10728 1399069
#> 10729 1399070
#> 10730 1399120
#> 10731 1399124
#> 10732 1399125
#> 10733 1399126
#> 10734 1399127
#> 10735 1399131
#> 10736 1399303
#> 10737 1399307
#> 10738 1399377
#> 10739 1400211
#> 10740 1401533
#> 10741 1401723
#> 10742 1401729
#> 10743 1401730
#> 10744 1401731
#> 10745 1401732
#> 10746 1401733
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#> 10748 1401735
#> 10749 1401736
#> 10750 1401737
#> 10751 1401738
#> 10752 1401739
#> 10753 1401740
#> 10754 1401741
#> 10755 1401742
#> 10756 1401743
#> 10757 1401744
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#> 10759 1401746
#> 10760 1401747
#> 10761 1401748
#> 10762 1401749
#> 10763 1401750
#> 10764 1401751
#> 10765 1401752
#> 10766 1401753
#> 10767 1401754
#> 10768 1401755
#> 10769 1401756
#> 10770 1401757
#> 10771 1401758
#> 10772 1401761
#> 10773 1401762
#> 10774 1401763
#> 10775 1401832
#> 10776 1401893
#> 10777 1401894
#> 10778 1401897
#> 10779 1402066
#> 10780 1402071
#> 10781 1402072
#> 10782 1402073
#> 10783 1402074
#> 10784 1402075
#> 10785 1402076
#> 10786 1402077
#> 10787 1402078
#> 10788 1402079
#> 10789 1402080
#> 10790 1402081
#> 10791 1402082
#> 10792 1402083
#> 10793 1402685
#> 10794 1402689
#> 10795 1402692
#> 10796 1402693
#> 10797 1402694
#> 10798 1402695
#> 10799 1402696
#> 10800 1402697
#> 10801 1402706
#> 10802 1402710
#> 10803 1402711
#> 10804 1402712
#> 10805 1402713
#> 10806 1402714
#> 10807 1402715
#> 10808 1402716
#> 10809 1402717
#> 10810 1402718
#> 10811 1402719
#> 10812 1402720
#> 10813 1402721
#> 10814 1402722
#> 10815 1402723
#> 10816 1402724
#> 10817 1402725
#> 10818 1402726
#> 10819 1402727
#> 10820 1402728
#> 10821 1402738
#> 10822 1402739
#> 10823 1402740
#> 10824 1402741
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#> 10829 1402746
#> 10830 1402747
#> 10831 1402748
#> 10832 1402749
#> 10833 1402750
#> 10834 1402751
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#> 10836 1402753
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#> 10838 1402755
#> 10839 1402756
#> 10840 1402757
#> 10841 1402758
#> 10842 1402759
#> 10843 1402760
#> 10844 1402761
#> 10845 1402762
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#> 10850 1402767
#> 10851 1402768
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#> 10853 1402770
#> 10854 1402771
#> 10855 1402772
#> 10856 1402773
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#> 10858 1402775
#> 10859 1402776
#> 10860 1402779
#> 10861 1402780
#> 10862 1402781
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#> 10866 1402785
#> 10867 1402786
#> 10868 1402796
#> 10869 1402797
#> 10870 1402821
#> 10871 1403375
#> 10872 1403414
#> 10873 1403522
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#> 10875 1403603
#> 10876 1403604
#> 10877 1403605
#> 10878 1403606
#> 10879 1403608
#> 10880 1403609
#> 10881 1403610
#> 10882 1403611
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#> 10884 1403613
#> 10885 1403614
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#> 10887 1403616
#> 10888 1403617
#> 10889 1403618
#> 10890 1403619
#> 10891 1403620
#> 10892 1403621
#> 10893 1403622
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#> 10895 1403720
#> 10896 1404169
#> 10897 1404298
#> 10898 1404315
#> 10899 1404316
#> 10900 1404317
#> 10901 1404318
#> 10902 1404319
#> 10903 1404320
#> 10904 1404321
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#> 10906 1404323
#> 10907 1404324
#> 10908 1404325
#> 10909 1404326
#> 10910 1404333
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#> 10912 1404335
#> 10913 1404336
#> 10914 1404337
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#> 10916 1404353
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#> 10930 1405716
#> 10931 1405717
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#> 10945 1406350
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#> 10951 1406357
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#> 10954 1406360
#> 10955 1406361
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#> 10957 1406363
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#> 10959 1406365
#> 10960 1406366
#> 10961 1406382
#> 10962 1406384
#> 10963 1406385
#> 10964 1406386
#> 10965 1406387
#> 10966 1406388
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#> 10968 1406390
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#> 10975 1406397
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#> 10978 1406400
#> 10979 1406401
#> 10980 1406402
#> 10981 1406403
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#> 10983 1406425
#> 10984 1406426
#> 10985 1406427
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#> 10987 1406440
#> 10988 1406448
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#> 10990 1406450
#> 10991 1406451
#> 10992 1406452
#> 10993 1406453
#> 10994 1406756
#> 10995 1407255
#> 10996 1407710
#> 10997 1407799
#> 10998 1407806
#> 10999 1407984
#> 11000 1408114
#> 11001 1408253
#> 11002 1408719
#> 11003 1408884
#> 11004 1408885
#> 11005 1408886
#> 11006 1409116
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#> 11008 1410218
#> 11009 1410219
#> 11010 1410220
#> 11011 1410221
#> 11012 1410222
#> 11013 1410223
#> 11014 1410224
#> 11015 1410339
#> 11016 1410420
#> 11017 1410421
#> 11018 1410422
#> 11019 1410910
#> 11020 1410911
#> 11021 1411801
#> 11022 1411921
#> 11023 1412411
#> 11024 1412412
#> 11025 1412413
#> 11026 1412784
#> 11027 1412954
#> 11028 1412961
#> 11029 1412980
#> 11030 1413230
#> 11031 1413820
#> 11032 1413965
#> 11033 1413966
#> 11034 1413967
#> 11035 1413971
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#> 11037 1413973
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#> 11039 1413975
#> 11040 1413976
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#> 11042 1413978
#> 11043 1413979
#> 11044 1413980
#> 11045 1413981
#> 11046 1413982
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#> 11048 1413985
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#> 11050 1413987
#> 11051 1414210
#> 11052 1414639
#> 11053 1414891
#> 11054 1414901
#> 11055 1414902
#> 11056 1414903
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#> 11058 1414919
#> 11059 1414920
#> 11060 1414921
#> 11061 1414922
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#> 11063 1414940
#> 11064 1414941
#> 11065 1414942
#> 11066 1414943
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#> 11068 1414945
#> 11069 1414949
#> 11070 1414950
#> 11071 1414951
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#> 11073 1415416
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#> 11075 1415418
#> 11076 1415422
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#> 11078 1415424
#> 11079 1415425
#> 11080 1415426
#> 11081 1415850
#> 11082 1415899
#> 11083 1415903
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#> 11085 1416608
#> 11086 1416609
#> 11087 1416610
#> 11088 1416611
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#> 11090 1416615
#> 11091 1416616
#> 11092 1416617
#> 11093 1417204
#> 11094 1417227
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#> 11096 1417229
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#> 11098 1418228
#> 11099 1418252
#> 11100 1418543
#> 11101 1418549
#> 11102 1418901
#> 11103 1419064
#> 11104 1419065
#> 11105 1419067
#> 11106 1419072
#> 11107 1419073
#> 11108 1419723
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#> 11110 1420819
#> 11111 1420984
#> 11112 1420995
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#> 11114 1420998
#> 11115 1420999
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#> 11117 1421001
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#> 11119 1421003
#> 11120 1421004
#> 11121 1421005
#> 11122 1421006
#> 11123 1421007
#> 11124 1421008
#> 11125 1421009
#> 11126 1421010
#> 11127 1421011
#> 11128 1421012
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#> 11130 1421015
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#> 11132 1421017
#> 11133 1421018
#> 11134 1421019
#> 11135 1421020
#> 11136 1421021
#> 11137 1421022
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#> 11139 1421025
#> 11140 1421026
#> 11141 1421027
#> 11142 1421028
#> 11143 1421029
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#> 11150 1421036
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#> 11160 1421046
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#> 11164 1421050
#> 11165 1421051
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#> 11175 1421061
#> 11176 1421062
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#> 11178 1421064
#> 11179 1421065
#> 11180 1421066
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#> 11189 1421075
#> 11190 1421076
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#> 11195 1421380
#> 11196 1421534
#> 11197 1421548
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#> 11215 1421800
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#> 11406 1430790
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#> 11408 1431177
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#> 11599 1444431
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#> 11678 1451522
#> 11679 1451523
#> 11680 1451524
#> 11681 1451525
#> 11682 1452102
#> 11683 1452108
#> 11684 1452125
#> 11685 1452213
#> 11686 1452247
#> 11687 1452253
#> 11688 1452254
#> 11689 1452256
#> 11690 1452257
#> 11691 1452259
#> 11692 1452261
#> 11693 1452262
#> 11694 1452264
#> 11695 1452265
#> 11696 1452266
#> 11697 1452279
#> 11698 1452327
#> 11699 1452613
#> 11700 1452614
#> 11701 1452615
#> 11702 1452628
#> 11703 1452789
#> 11704 1452790
#> 11705 1453057
#> 11706 1453200
#> 11707 1453387
#> 11708 1453470
#> 11709 1453475
#> 11710 1453476
#> 11711 1453477
#> 11712 1453478
#> 11713 1453479
#> 11714 1453480
#> 11715 1453481
#> 11716 1453482
#> 11717 1453483
#> 11718 1453484
#> 11719 1453485
#> 11720 1453486
#> 11721 1453487
#> 11722 1453488
#> 11723 1453489
#> 11724 1453490
#> 11725 1453491
#> 11726 1453492
#> 11727 1453493
#> 11728 1453494
#> 11729 1453695
#> 11730 1453887
#> 11731 1453888
#> 11732 1453889
#> 11733 1453910
#> 11734 1453922
#> 11735 1454070
#> 11736 1454136
#> 11737 1454144
#> 11738 1454145
#> 11739 1454146
#> 11740 1454147
#> 11741 1454152
#> 11742 1454153
#> 11743 1454154
#> 11744 1454160
#> 11745 1454290
#> 11746 1454291
#> 11747 1454292
#> 11748 1454346
#> 11749 1454747
#> 11750 1454934
#> 11751 1455420
#> 11752 1457631
#> 11753 1457636
#> 11754 1457645
#> 11755 1457646
#> 11756 1457647
#> 11757 1457651
#> 11758 1457652
#> 11759 1457653
#> 11760 1457654
#> 11761 1457655
#> 11762 1457656
#> 11763 1457657
#> 11764 1457658
#> 11765 1457659
#> 11766 1457660
#> 11767 1457661
#> 11768 1457662
#> 11769 1457663
#> 11770 1457664
#> 11771 1457665
#> 11772 1457666
#> 11773 1457667
#> 11774 1457668
#> 11775 1457669
#> 11776 1457670
#> 11777 1457671
#> 11778 1457672
#> 11779 1457673
#> 11780 1457674
#> 11781 1457675
#> 11782 1457676
#> 11783 1457677
#> 11784 1457678
#> 11785 1457679
#> 11786 1457680
#> 11787 1457681
#> 11788 1457682
#> 11789 1458342
#> 11790 1458343
#> 11791 1458381
#> 11792 1458382
#> 11793 1458383
#> 11794 1458384
#> 11795 1458385
#> 11796 1458386
#> 11797 1458387
#> 11798 1458388
#> 11799 1458389
#> 11800 1458390
#> 11801 1458391
#> 11802 1458392
#> 11803 1458393
#> 11804 1458394
#> 11805 1458395
#> 11806 1458402
#> 11807 1458403
#> 11808 1458692
#> 11809 1458693
#> 11810 1458821
#> 11811 1458879
#> 11812 1458881
#> 11813 1458883
#> 11814 1458885
#> 11815 1458887
#> 11816 1459193
#> 11817 1459194
#> 11818 1459195
#> 11819 1459196
#> 11820 1459197
#> 11821 1459198
#> 11822 1459202
#> 11823 1459203
#> 11824 1459204
#> 11825 1459611
#> 11826 1459617
#> 11827 1459618
#> 11828 1459619
#> 11829 1459630
#> 11830 1459829
#> 11831 1459830
#> 11832 1459925
#> 11833 1459930
#> 11834 1459932
#> 11835 1459934
#> 11836 1459939
#> 11837 1459940
#> 11838 1459941
#> 11839 1459942
#> 11840 1459945
#> 11841 1460295
#> 11842 1460351
#> 11843 1460352
#> 11844 1460353
#> 11845 1460354
#> 11846 1460611
#> 11847 1460615
#> 11848 1460868
#> 11849 1460873
#> 11850 1461629
#> 11851 1461632
#> 11852 1462042
#> 11853 1462043
#> 11854 1463416
#> 11855 1463437
#> 11856 1463438
#> 11857 1463444
#> 11858 1463976
#> 11859 1463977
#> 11860 1463979
#> 11861 1463980
#> 11862 1463981
#> 11863 1463982
#> 11864 1463984
#> 11865 1464224
#> 11866 1464225
#> 11867 1464226
#> 11868 1464227
#> 11869 1464228
#> 11870 1464229
#> 11871 1464782
#> 11872 1464921
#> 11873 1465169
#> 11874 1465531
#> 11875 1465532
#> 11876 1465533
#> 11877 1465534
#> 11878 1465535
#> 11879 1465536
#> 11880 1465537
#> 11881 1465538
#> 11882 1465539
#> 11883 1465540
#> 11884 1465929
#> 11885 1465940
#> 11886 1465941
#> 11887 1465994
#> 11888 1465995
#> 11889 1466056
#> 11890 1466162
#> 11891 1466167
#> 11892 1466168
#> 11893 1466169
#> 11894 1466170
#> 11895 1466171
#> 11896 1466172
#> 11897 1466173
#> 11898 1466174
#> 11899 1466175
#> 11900 1466176
#> 11901 1466177
#> 11902 1466178
#> 11903 1466179
#> 11904 1466180
#> 11905 1466181
#> 11906 1466182
#> 11907 1466183
#> 11908 1466184
#> 11909 1466185
#> 11910 1466186
#> 11911 1466243
#> 11912 1466249
#> 11913 1466250
#> 11914 1466251
#> 11915 1466252
#> 11916 1466253
#> 11917 1466254
#> 11918 1466255
#> 11919 1466256
#> 11920 1466257
#> 11921 1466258
#> 11922 1466354
#> 11923 1466708
#> 11924 1466729
#> 11925 1466730
#> 11926 1466731
#> 11927 1466732
#> 11928 1466736
#> 11929 1467167
#> 11930 1467286
#> 11931 1467295
#> 11932 1467329
#> 11933 1467330
#> 11934 1467331
#> 11935 1467332
#> 11936 1467333
#> 11937 1467334
#> 11938 1467344
#> 11939 1467345
#> 11940 1467346
#> 11941 1467347
#> 11942 1467590
#> 11943 1467732
#> 11944 1467735
#> 11945 1468094
#> 11946 1468136
#> 11947 1468137
#> 11948 1468138
#> 11949 1468139
#> 11950 1468148
#> 11951 1468149
#> 11952 1468155
#> 11953 1468160
#> 11954 1468165
#> 11955 1468170
#> 11956 1468175
#> 11957 1469211
#> 11958 1469214
#> 11959 1469226
#> 11960 1469227
#> 11961 1469802
#> 11962 1470745
#> 11963 1470749
#> 11964 1470770
#> 11965 1470772
#> 11966 1470781
#> 11967 1470784
#> 11968 1470788
#> 11969 1470917
#> 11970 1470921
#> 11971 1470922
#> 11972 1471049
#> 11973 1471052
#> 11974 1471053
#> 11975 1471096
#> 11976 1471178
#> 11977 1471422
#> 11978 1471732
#> 11979 1471736
#> 11980 1472959
#> 11981 1474397
#> 11982 1474400
#> 11983 1474888
#> 11984 1475680
#> 11985 1475681
#> 11986 1475682
#> 11987 1475793
#> 11988 1475794
#> 11989 1475795
#> 11990 1475796
#> 11991 1475797
#> 11992 1475798
#> 11993 1475804
#> 11994 1475805
#> 11995 1475806
#> 11996 1475809
#> 11997 1475810
#> 11998 1475811
#> 11999 1475812
#> 12000 1476840
#> 12001 1478423
#> 12002 1478427
#> 12003 1478428
#> 12004 1478429
#> 12005 1478430
#> 12006 1478431
#> 12007 1478432
#> 12008 1478433
#> 12009 1478434
#> 12010 1478435
#> 12011 1478436
#> 12012 1478437
#> 12013 1478480
#> 12014 1478481
#> 12015 1478482
#> 12016 1478483
#> 12017 1478484
#> 12018 1478485
#> 12019 1478486
#> 12020 1478590
#> 12021 1478598
#> 12022 1478701
#> 12023 1478702
#> 12024 1478727
#> 12025 1478745
#> 12026 1478746
#> 12027 1478817
#> 12028 1480298
#> 12029 1480299
#> 12030 1480300
#> 12031 1480587
#> 12032 1480668
#> 12033 1480672
#> 12034 1480675
#> 12035 1480676
#> 12036 1480677
#> 12037 1480678
#> 12038 1480679
#> 12039 1480680
#> 12040 1480681
#> 12041 1480682
#> 12042 1480683
#> 12043 1480684
#> 12044 1480685
#> 12045 1480686
#> 12046 1480687
#> 12047 1480688
#> 12048 1480689
#> 12049 1480690
#> 12050 1480691
#> 12051 1480692
#> 12052 1480693
#> 12053 1480694
#> 12054 1480695
#> 12055 1480696
#> 12056 1480697
#> 12057 1480698
#> 12058 1480699
#> 12059 1480700
#> 12060 1480701
#> 12061 1480702
#> 12062 1480703
#> 12063 1480704
#> 12064 1480705
#> 12065 1480706
#> 12066 1480707
#> 12067 1480708
#> 12068 1480709
#> 12069 1480710
#> 12070 1480711
#> 12071 1480712
#> 12072 1480713
#> 12073 1480738
#> 12074 1480744
#> 12075 1480749
#> 12076 1481785
#> 12077 1482176
#> 12078 1482178
#> 12079 1482180
#> 12080 1482182
#> 12081 1483567
#> 12082 1483572
#> 12083 1483823
#> 12084 1484986
#> 12085 1485222
#> 12086 1485223
#> 12087 1485224
#> 12088 1485225
#> 12089 1485226
#> 12090 1485227
#> 12091 1485228
#> 12092 1485229
#> 12093 1485230
#> 12094 1485231
#> 12095 1485240
#> 12096 1485241
#> 12097 1485242
#> 12098 1485257
#> 12099 1485258
#> 12100 1485259
#> 12101 1485260
#> 12102 1485261
#> 12103 1485262
#> 12104 1485263
#> 12105 1486250
#> 12106 1486299
#> 12107 1486673
#> 12108 1486761
#> 12109 1487202
#> 12110 1487203
#> 12111 1487504
#> 12112 1487508
#> 12113 1487509
#> 12114 1487510
#> 12115 1487511
#> 12116 1487512
#> 12117 1487514
#> 12118 1487515
#> 12119 1487516
#> 12120 1487691
#> 12121 1487692
#> 12122 1487693
#> 12123 1487694
#> 12124 1487695
#> 12125 1487696
#> 12126 1487697
#> 12127 1487698
#> 12128 1487699
#> 12129 1487700
#> 12130 1487701
#> 12131 1487702
#> 12132 1487703
#> 12133 1487704
#> 12134 1487705
#> 12135 1487716
#> 12136 1488291
#> 12137 1488397
#> 12138 1488398
#> 12139 1488487
#> 12140 1488615
#> 12141 1488687
#> 12142 1488707
#> 12143 1489043
#> 12144 1489075
#> 12145 1489127
#> 12146 1489378
#> 12147 1489605
#> 12148 1490938
#> 12149 1490950
#> 12150 1490954
#> 12151 1490955
#> 12152 1490956
#> 12153 1490959
#> 12154 1491051
#> 12155 1491121
#> 12156 1491122
#> 12157 1491123
#> 12158 1491209
#> 12159 1491469
#> 12160 1491478
#> 12161 1491479
#> 12162 1491480
#> 12163 1491481
#> 12164 1491483
#> 12165 1492837
#> 12166 1493938
#> 12167 1493969
#> 12168 1495471
#> 12169 1496084
#> 12170 1496299
#> 12171 1497216
#> 12172 1497324
#> 12173 1497329
#> 12174 1497330
#> 12175 1497331
#> 12176 1497332
#> 12177 1497333
#> 12178 1497334
#> 12179 1497335
#> 12180 1497336
#> 12181 1497337
#> 12182 1497338
#> 12183 1497339
#> 12184 1497340
#> 12185 1497341
#> 12186 1497342
#> 12187 1497343
#> 12188 1497344
#> 12189 1497345
#> 12190 1497346
#> 12191 1497347
#> 12192 1497348
#> 12193 1497349
#> 12194 1497350
#> 12195 1497351
#> 12196 1497352
#> 12197 1497353
#> 12198 1497354
#> 12199 1497355
#> 12200 1497601
#> 12201 1497619
#> 12202 1497696
#> 12203 1498138
#> 12204 1498375
#> 12205 1498975
#> 12206 1499200
#> 12207 1499244
#> 12208 1500282
#> 12209 1500913
#> 12210 1500915
#> 12211 1501177
#> 12212 1501688
#> 12213 1501911
#> 12214 1503033
#> 12215 1503043
#> 12216 1503044
#> 12217 1503477
#> 12218 1503613
#> 12219 1503615
#> 12220 1503617
#> 12221 1503724
#> 12222 1503736
#> 12223 1503760
#> 12224 1504183
#> 12225 1504263
#> 12226 1504286
#> 12227 1504423
#> 12228 1504424
#> 12229 1504508
#> 12230 1504527
#> 12231 1504728
#> 12232 1504729
#> 12233 1504730
#> 12234 1504734
#> 12235 1504739
#> 12236 1504740
#> 12237 1504769
#> 12238 1504868
#> 12239 1505179
#> 12240 1506516
#> 12241 1506694
#> 12242 1506733
#> 12243 1506878
#> 12244 1507657
#> 12245 1507679
#> 12246 1507904
#> 12247 1507909
#> 12248 1507913
#> 12249 1509521
#> 12250 1511021
#> 12251 1511022
#> 12252 1511023
#> 12253 1511024
#> 12254 1511027
#> 12255 1511043
#> 12256 1511217
#> 12257 1511227
#> 12258 1511235
#> 12259 1511464
#> 12260 1511465
#> 12261 1511466
#> 12262 1512194
#> 12263 1512675
#> 12264 1512696
#> 12265 1513911
#> 12266 1513912
#> 12267 1514432
#> 12268 1514436
#> 12269 1514437
#> 12270 1514438
#> 12271 1514439
#> 12272 1514440
#> 12273 1514441
#> 12274 1514442
#> 12275 1514582
#> 12276 1514583
#> 12277 1515182
#> 12278 1515186
#> 12279 1515187
#> 12280 1515188
#> 12281 1515189
#> 12282 1515190
#> 12283 1515191
#> 12284 1515192
#> 12285 1515193
#> 12286 1515194
#> 12287 1515195
#> 12288 1515196
#> 12289 1515197
#> 12290 1515198
#> 12291 1515199
#> 12292 1515200
#> 12293 1515201
#> 12294 1515202
#> 12295 1515203
#> 12296 1515204
#> 12297 1515205
#> 12298 1515206
#> 12299 1515207
#> 12300 1515208
#> 12301 1515209
#> 12302 1515210
#> 12303 1515211
#> 12304 1515212
#> 12305 1515213
#> 12306 1515214
#> 12307 1515215
#> 12308 1515216
#> 12309 1515219
#> 12310 1515220
#> 12311 1515221
#> 12312 1515222
#> 12313 1515223
#> 12314 1515224
#> 12315 1515225
#> 12316 1515226
#> 12317 1515238
#> 12318 1515383
#> 12319 1515384
#> 12320 1515385
#> 12321 1515386
#> 12322 1515388
#> 12323 1515389
#> 12324 1515390
#> 12325 1515391
#> 12326 1515396
#> 12327 1517357
#> 12328 1517361
#> 12329 1517362
#> 12330 1517363
#> 12331 1517364
#> 12332 1517365
#> 12333 1517366
#> 12334 1517367
#> 12335 1517368
#> 12336 1517369
#> 12337 1517370
#> 12338 1517371
#> 12339 1517372
#> 12340 1517373
#> 12341 1517374
#> 12342 1517375
#> 12343 1517376
#> 12344 1517377
#> 12345 1517378
#> 12346 1517379
#> 12347 1517380
#> 12348 1517381
#> 12349 1517382
#> 12350 1517383
#> 12351 1517384
#> 12352 1517385
#> 12353 1517386
#> 12354 1517387
#> 12355 1517388
#> 12356 1517389
#> 12357 1517390
#> 12358 1517391
#> 12359 1517392
#> 12360 1517393
#> 12361 1517394
#> 12362 1517395
#> 12363 1517396
#> 12364 1517397
#> 12365 1517398
#> 12366 1517399
#> 12367 1517400
#> 12368 1517401
#> 12369 1518071
#> 12370 1519240
#> 12371 1519241
#> 12372 1519242
#> 12373 1519243
#> 12374 1519244
#> 12375 1519245
#> 12376 1519412
#> 12377 1519439
#> 12378 1519440
#> 12379 1519441
#> 12380 1519442
#> 12381 1519640
#> 12382 1520043
#> 12383 1520047
#> 12384 1520048
#> 12385 1520050
#> 12386 1520051
#> 12387 1520141
#> 12388 1520144
#> 12389 1520145
#> 12390 1520213
#> 12391 1520217
#> 12392 1520221
#> 12393 1520268
#> 12394 1520269
#> 12395 1520270
#> 12396 1520271
#> 12397 1520272
#> 12398 1520273
#> 12399 1520329
#> 12400 1520345
#> 12401 1520369
#> 12402 1520393
#> 12403 1524219
#> 12404 1524241
#> 12405 1524242
#> 12406 1524243
#> 12407 1524244
#> 12408 1524245
#> 12409 1524246
#> 12410 1524247
#> 12411 1524248
#> 12412 1524249
#> 12413 1524250
#> 12414 1524251
#> 12415 1524252
#> 12416 1524254
#> 12417 1524256
#> 12418 1524258
#> 12419 1524259
#> 12420 1524262
#> 12421 1524265
#> 12422 1524266
#> 12423 1524273
#> 12424 1524275
#> 12425 1524277
#> 12426 1524278
#> 12427 1524284
#> 12428 1524285
#> 12429 1524286
#> 12430 1524287
#> 12431 1524289
#> 12432 1524291
#> 12433 1524293
#> 12434 1524294
#> 12435 1524296
#> 12436 1524298
#> 12437 1524300
#> 12438 1524307
#> 12439 1524308
#> 12440 1524309
#> 12441 1524310
#> 12442 1524311
#> 12443 1524312
#> 12444 1524318
#> 12445 1524323
#> 12446 1524342
#> 12447 1524345
#> 12448 1524348
#> 12449 1524351
#> 12450 1524354
#> 12451 1524361
#> 12452 1524362
#> 12453 1524363
#> 12454 1524364
#> 12455 1524365
#> 12456 1524366
#> 12457 1524369
#> 12458 1524370
#> 12459 1524371
#> 12460 1524372
#> 12461 1524373
#> 12462 1524374
#> 12463 1524375
#> 12464 1524556
#> 12465 1524561
#> 12466 1524573
#> 12467 1524601
#> 12468 1524652
#> 12469 1525028
#> 12470 1525044
#> 12471 1525059
#> 12472 1525060
#> 12473 1525198
#> 12474 1525202
#> 12475 1525206
#> 12476 1525207
#> 12477 1525208
#> 12478 1525209
#> 12479 1525210
#> 12480 1525211
#> 12481 1525212
#> 12482 1525248
#> 12483 1525715
#> 12484 1525716
#> 12485 1525719
#> 12486 1525720
#> 12487 1525721
#> 12488 1525722
#> 12489 1525723
#> 12490 1525724
#> 12491 1525725
#> 12492 1525726
#> 12493 1525727
#> 12494 1525728
#> 12495 1525729
#> 12496 1525730
#> 12497 1525731
#> 12498 1525732
#> 12499 1525733
#> 12500 1525734
#> 12501 1525735
#> 12502 1525736
#> 12503 1525737
#> 12504 1525738
#> 12505 1525739
#> 12506 1525740
#> 12507 1525741
#> 12508 1525742
#> 12509 1525743
#> 12510 1525744
#> 12511 1525745
#> 12512 1525746
#> 12513 1525747
#> 12514 1525748
#> 12515 1525749
#> 12516 1525750
#> 12517 1525751
#> 12518 1525752
#> 12519 1525753
#> 12520 1525754
#> 12521 1525755
#> 12522 1525757
#> 12523 1525758
#> 12524 1525759
#> 12525 1525760
#> 12526 1525761
#> 12527 1525762
#> 12528 1525763
#> 12529 1525764
#> 12530 1525765
#> 12531 1525766
#> 12532 1525767
#> 12533 1525770
#> 12534 1525771
#> 12535 1525783
#> 12536 1525785
#> 12537 1525786
#> 12538 1525787
#> 12539 1525788
#> 12540 1525789
#> 12541 1525790
#> 12542 1525791
#> 12543 1525798
#> 12544 1525881
#> 12545 1528517
#> 12546 1528729
#> 12547 1529212
#> 12548 1529217
#> 12549 1529218
#> 12550 1529221
#> 12551 1529869
#> 12552 1529998
#> 12553 1530488
#> 12554 1530489
#> 12555 1530490
#> 12556 1530501
#> 12557 1530524
#> 12558 1532050
#> 12559 1532244
#> 12560 1532245
#> 12561 1532246
#> 12562 1532247
#> 12563 1532248
#> 12564 1532249
#> 12565 1532250
#> 12566 1532251
#> 12567 1532252
#> 12568 1532253
#> 12569 1532254
#> 12570 1532255
#> 12571 1532256
#> 12572 1532257
#> 12573 1532258
#> 12574 1532259
#> 12575 1532260
#> 12576 1532261
#> 12577 1532262
#> 12578 1532263
#> 12579 1532264
#> 12580 1532265
#> 12581 1532266
#> 12582 1532267
#> 12583 1532268
#> 12584 1532269
#> 12585 1532270
#> 12586 1532271
#> 12587 1532272
#> 12588 1532273
#> 12589 1532274
#> 12590 1532275
#> 12591 1532466
#> 12592 1532473
#> 12593 1532474
#> 12594 1532475
#> 12595 1532491
#> 12596 1532492
#> 12597 1532500
#> 12598 1532505
#> 12599 1532506
#> 12600 1532507
#> 12601 1532508
#> 12602 1532509
#> 12603 1532510
#> 12604 1532662
#> 12605 1532663
#> 12606 1532683
#> 12607 1532691
#> 12608 1532692
#> 12609 1532710
#> 12610 1532846
#> 12611 1532855
#> 12612 1532866
#> 12613 1533309
#> 12614 1533310
#> 12615 1533462
#> 12616 1533529
#> 12617 1533531
#> 12618 1533532
#> 12619 1533533
#> 12620 1533534
#> 12621 1533535
#> 12622 1533536
#> 12623 1533537
#> 12624 1533538
#> 12625 1533539
#> 12626 1533540
#> 12627 1533541
#> 12628 1533542
#> 12629 1533543
#> 12630 1533544
#> 12631 1533545
#> 12632 1533546
#> 12633 1533547
#> 12634 1533548
#> 12635 1533558
#> 12636 1534694
#> 12637 1534704
#> 12638 1535014
#> 12639 1535572
#> 12640 1536153
#> 12641 1537019
#> 12642 1537025
#> 12643 1537190
#> 12644 1537194
#> 12645 1537196
#> 12646 1537197
#> 12647 1537198
#> 12648 1537199
#> 12649 1537200
#> 12650 1537201
#> 12651 1537202
#> 12652 1537203
#> 12653 1537387
#> 12654 1537388
#> 12655 1537389
#> 12656 1537391
#> 12657 1537392
#> 12658 1537393
#> 12659 1537394
#> 12660 1537395
#> 12661 1537669
#> 12662 1537715
#> 12663 1537835
#> 12664 1537847
#> 12665 1538664
#> 12666 1538679
#> 12667 1538700
#> 12668 1538708
#> 12669 1538724
#> 12670 1538725
#> 12671 1538726
#> 12672 1538727
#> 12673 1538728
#> 12674 1538729
#> 12675 1538730
#> 12676 1538731
#> 12677 1538732
#> 12678 1538733
#> 12679 1538734
#> 12680 1538735
#> 12681 1538736
#> 12682 1538737
#> 12683 1538738
#> 12684 1539056
#> 12685 1539057
#> 12686 1539063
#> 12687 1539071
#> 12688 1539072
#> 12689 1539073
#> 12690 1539074
#> 12691 1539075
#> 12692 1539076
#> 12693 1539077
#> 12694 1539079
#> 12695 1539082
#> 12696 1539103
#> 12697 1539104
#> 12698 1539108
#> 12699 1540252
#> 12700 1540632
#> 12701 1541664
#> 12702 1541723
#> 12703 1541741
#> 12704 1541742
#> 12705 1541743
#> 12706 1541746
#> 12707 1541747
#> 12708 1541748
#> 12709 1541749
#> 12710 1541750
#> 12711 1541751
#> 12712 1541752
#> 12713 1541753
#> 12714 1541754
#> 12715 1541755
#> 12716 1541756
#> 12717 1541757
#> 12718 1541758
#> 12719 1541759
#> 12720 1541760
#> 12721 1541761
#> 12722 1541762
#> 12723 1541763
#> 12724 1541764
#> 12725 1541765
#> 12726 1541766
#> 12727 1541767
#> 12728 1542169
#> 12729 1542923
#> 12730 1543034
#> 12731 1543120
#> 12732 1543126
#> 12733 1543186
#> 12734 1543459
#> 12735 1543503
#> 12736 1543506
#> 12737 1543507
#> 12738 1543509
#> 12739 1543511
#> 12740 1543513
#> 12741 1543515
#> 12742 1543517
#> 12743 1543519
#> 12744 1543523
#> 12745 1544072
#> 12746 1544398
#> 12747 1544657
#> 12748 1544658
#> 12749 1544659
#> 12750 1544660
#> 12751 1544661
#> 12752 1544662
#> 12753 1544789
#> 12754 1545041
#> 12755 1545102
#> 12756 1545103
#> 12757 1545105
#> 12758 1545106
#> 12759 1545120
#> 12760 1545410
#> 12761 1545757
#> 12762 1545777
#> 12763 1545844
#> 12764 1545849
#> 12765 1545855
#> 12766 1545866
#> 12767 1545879
#> 12768 1545881
#> 12769 1545905
#> 12770 1545953
#> 12771 1545993
#> 12772 1546456
#> 12773 1546536
#> 12774 1546556
#> 12775 1546565
#> 12776 1546572
#> 12777 1546624
#> 12778 1546626
#> 12779 1546630
#> 12780 1546631
#> 12781 1546799
#> 12782 1546809
#> 12783 1546982
#> 12784 1547112
#> 12785 1547148
#> 12786 1547959
#> 12787 1547967
#> 12788 1548244
#> 12789 1548256
#> 12790 1548257
#> 12791 1548986
#> 12792 1548987
#> 12793 1549101
#> 12794 1549674
#> 12795 1549868
#> 12796 1549906
#> 12797 1549917
#> 12798 1549920
#> 12799 1549929
#> 12800 1549934
#> 12801 1549935
#> 12802 1550000
#> 12803 1550094
#> 12804 1550096
#> 12805 1550103
#> 12806 1550542
#> 12807 1550785
#> 12808 1550794
#> 12809 1550795
#> 12810 1550796
#> 12811 1550797
#> 12812 1551329
#> 12813 1551768
#> 12814 1551769
#> 12815 1551893
#> 12816 1552549
#> 12817 1552710
#> 12818 1552862
#> 12819 1553416
#> 12820 1555771
#> 12821 1555772
#> 12822 1555773
#> 12823 1555827
#> 12824 1555834
#> 12825 1556024
#> 12826 1556109
#> 12827 1556148
#> 12828 1556149
#> 12829 1556150
#> 12830 1556151
#> 12831 1556162
#> 12832 1556163
#> 12833 1556604
#> 12834 1556835
#> 12835 1556842
#> 12836 1556846
#> 12837 1557387
#> 12838 1557391
#> 12839 1557398
#> 12840 1557466
#> 12841 1557960
#> 12842 1558384
#> 12843 1558412
#> 12844 1558434
#> 12845 1558483
#> 12846 1558800
#> 12847 1558802
#> 12848 1558803
#> 12849 1558804
#> 12850 1558805
#> 12851 1558806
#> 12852 1559382
#> 12853 1559492
#> 12854 1559494
#> 12855 1559496
#> 12856 1559497
#> 12857 1559500
#> 12858 1559503
#> 12859 1559505
#> 12860 1559506
#> 12861 1559509
#> 12862 1559511
#> 12863 1559514
#> 12864 1559517
#> 12865 1559519
#> 12866 1559521
#> 12867 1559523
#> 12868 1559525
#> 12869 1559527
#> 12870 1559529
#> 12871 1559531
#> 12872 1559532
#> 12873 1559535
#> 12874 1559537
#> 12875 1559539
#> 12876 1559541
#> 12877 1559543
#> 12878 1559545
#> 12879 1559547
#> 12880 1560693
#> 12881 1560787
#> 12882 1561076
#> 12883 1561152
#> 12884 1561153
#> 12885 1561172
#> 12886 1561173
#> 12887 1561176
#> 12888 1561178
#> 12889 1561179
#> 12890 1561180
#> 12891 1561181
#> 12892 1561182
#> 12893 1561183
#> 12894 1561184
#> 12895 1561185
#> 12896 1561187
#> 12897 1561188
#> 12898 1561189
#> 12899 1561190
#> 12900 1561193
#> 12901 1561194
#> 12902 1561195
#> 12903 1561196
#> 12904 1561197
#> 12905 1561198
#> 12906 1561199
#> 12907 1561200
#> 12908 1561201
#> 12909 1561202
#> 12910 1561271
#> 12911 1561275
#> 12912 1561331
#> 12913 1562379
#> 12914 1562382
#> 12915 1562766
#> 12916 1562843
#> 12917 1562944
#> 12918 1562985
#> 12919 1564182
#> 12920 1564441
#> 12921 1564454
#> 12922 1564455
#> 12923 1564456
#> 12924 1564457
#> 12925 1564458
#> 12926 1564459
#> 12927 1564460
#> 12928 1564461
#> 12929 1564462
#> 12930 1564463
#> 12931 1564464
#> 12932 1564465
#> 12933 1564481
#> 12934 1564482
#> 12935 1564483
#> 12936 1564484
#> 12937 1564485
#> 12938 1564774
#> 12939 1564790
#> 12940 1564791
#> 12941 1564792
#> 12942 1564793
#> 12943 1565073
#> 12944 1565721
#> 12945 1565922
#> 12946 1566496
#> 12947 1566497
#> 12948 1566537
#> 12949 1566557
#> 12950 1566942
#> 12951 1567110
#> 12952 1567111
#> 12953 1567217
#> 12954 1567364
#> 12955 1567367
#> 12956 1567604
#> 12957 1567606
#> 12958 1568249
#> 12959 1568290
#> 12960 1568297
#> 12961 1568298
#> 12962 1568299
#> 12963 1568300
#> 12964 1568312
#> 12965 1568317
#> 12966 1568318
#> 12967 1568319
#> 12968 1568320
#> 12969 1568321
#> 12970 1568329
#> 12971 1568330
#> 12972 1568731
#> 12973 1568733
#> 12974 1568869
#> 12975 1568971
#> 12976 1569611
#> 12977 1569612
#> 12978 1570108
#> 12979 1570325
#> 12980 1570334
#> 12981 1570338
#> 12982 1570341
#> 12983 1570368
#> 12984 1570369
#> 12985 1570370
#> 12986 1570371
#> 12987 1570372
#> 12988 1570808
#> 12989 1570809
#> 12990 1570810
#> 12991 1570811
#> 12992 1570812
#> 12993 1571163
#> 12994 1571172
#> 12995 1571185
#> 12996 1571188
#> 12997 1571427
#> 12998 1571511
#> 12999 1571517
#> 13000 1571558
#> 13001 1571559
#> 13002 1571599
#> 13003 1571600
#> 13004 1571601
#> 13005 1571602
#> 13006 1571603
#> 13007 1571604
#> 13008 1571606
#> 13009 1571607
#> 13010 1571608
#> 13011 1571609
#> 13012 1571610
#> 13013 1571611
#> 13014 1571612
#> 13015 1571613
#> 13016 1571614
#> 13017 1571615
#> 13018 1571616
#> 13019 1571621
#> 13020 1572255
#> 13021 1572263
#> 13022 1572264
#> 13023 1572265
#> 13024 1572266
#> 13025 1572267
#> 13026 1572269
#> 13027 1572270
#> 13028 1572271
#> 13029 1572272
#> 13030 1572273
#> 13031 1572287
#> 13032 1572556
#> 13033 1572568
#> 13034 1572569
#> 13035 1572570
#> 13036 1572571
#> 13037 1572572
#> 13038 1572573
#> 13039 1572574
#> 13040 1572580
#> 13041 1572591
#> 13042 1572598
#> 13043 1572839
#> 13044 1572840
#> 13045 1572848
#> 13046 1572849
#> 13047 1574047
#> 13048 1574088
#> 13049 1574089
#> 13050 1574195
#> 13051 1574269
#> 13052 1574272
#> 13053 1574273
#> 13054 1574274
#> 13055 1574275
#> 13056 1574276
#> 13057 1574277
#> 13058 1574278
#> 13059 1574279
#> 13060 1574280
#> 13061 1574284
#> 13062 1574285
#> 13063 1574435
#> 13064 1574436
#> 13065 1574450
#> 13066 1574451
#> 13067 1574497
#> 13068 1574498
#> 13069 1574499
#> 13070 1574500
#> 13071 1574501
#> 13072 1574502
#> 13073 1574503
#> 13074 1574504
#> 13075 1574505
#> 13076 1574506
#> 13077 1574507
#> 13078 1574595
#> 13079 1574596
#> 13080 1574597
#> 13081 1574598
#> 13082 1574599
#> 13083 1574609
#> 13084 1574611
#> 13085 1574612
#> 13086 1574613
#> 13087 1575077
#> 13088 1575291
#> 13089 1575293
#> 13090 1575480
#> 13091 1575595
#> 13092 1575634
#> 13093 1576848
#> 13094 1576849
#> 13095 1576850
#> 13096 1577581
#> 13097 1577643
#> 13098 1577659
#> 13099 1577663
#> 13100 1577682
#> 13101 1577692
#> 13102 1577700
#> 13103 1577718
#> 13104 1577724
#> 13105 1577896
#> 13106 1578156
#> 13107 1578239
#> 13108 1578247
#> 13109 1578248
#> 13110 1578249
#> 13111 1578250
#> 13112 1578251
#> 13113 1578252
#> 13114 1578253
#> 13115 1578254
#> 13116 1578255
#> 13117 1578256
#> 13118 1578257
#> 13119 1578258
#> 13120 1578515
#> 13121 1578516
#> 13122 1579160
#> 13123 1580238
#> 13124 1580659
#> 13125 1580663
#> 13126 1580691
#> 13127 1580692
#> 13128 1580693
#> 13129 1581560
#> 13130 1581820
#> 13131 1581821
#> 13132 1581822
#> 13133 1581823
#> 13134 1581987
#> 13135 1581988
#> 13136 1582591
#> 13137 1582701
#> 13138 1582702
#> 13139 1582703
#> 13140 1582704
#> 13141 1582705
#> 13142 1582706
#> 13143 1582707
#> 13144 1582708
#> 13145 1582709
#> 13146 1582710
#> 13147 1582711
#> 13148 1582712
#> 13149 1582716
#> 13150 1583164
#> 13151 1583165
#> 13152 1583364
#> 13153 1585715
#> 13154 1586322
#> 13155 1586360
#> 13156 1586767
#> 13157 1586782
#> 13158 1587303
#> 13159 1587308
#> 13160 1587358
#> 13161 1587635
#> 13162 1587831
#> 13163 1587852
#> 13164 1587860
#> 13165 1587861
#> 13166 1588021
#> 13167 1588122
#> 13168 1588343
#> 13169 1588374
#> 13170 1588375
#> 13171 1588376
#> 13172 1588377
#> 13173 1588379
#> 13174 1588383
#> 13175 1588385
#> 13176 1588386
#> 13177 1588387
#> 13178 1588388
#> 13179 1588389
#> 13180 1588390
#> 13181 1588498
#> 13182 1588500
#> 13183 1588585
#> 13184 1588962
#> 13185 1589101
#> 13186 1589102
#> 13187 1589103
#> 13188 1589104
#> 13189 1589113
#> 13190 1589114
#> 13191 1589115
#> 13192 1589116
#> 13193 1589117
#> 13194 1589143
#> 13195 1589147
#> 13196 1589218
#> 13197 1589219
#> 13198 1589220
#> 13199 1589221
#> 13200 1589660
#> 13201 1589825
#> 13202 1589949
#> 13203 1589950
#> 13204 1589955
#> 13205 1589993
#> 13206 1590016
#> 13207 1590027
#> 13208 1590028
#> 13209 1590029
#> 13210 1590030
#> 13211 1590031
#> 13212 1590147
#> 13213 1590317
#> 13214 1590318
#> 13215 1590319
#> 13216 1590320
#> 13217 1590321
#> 13218 1590322
#> 13219 1590323
#> 13220 1590324
#> 13221 1590325
#> 13222 1590326
#> 13223 1590327
#> 13224 1590329
#> 13225 1590330
#> 13226 1590331
#> 13227 1590332
#> 13228 1590333
#> 13229 1590334
#> 13230 1590335
#> 13231 1590336
#> 13232 1590337
#> 13233 1590338
#> 13234 1590339
#> 13235 1590340
#> 13236 1590341
#> 13237 1590342
#> 13238 1591559
#> 13239 1591718
#> 13240 1591719
#> 13241 1591738
#> 13242 1591746
#> 13243 1593167
#> 13244 1593198
#> 13245 1593199
#> 13246 1593200
#> 13247 1593204
#> 13248 1593648
#> 13249 1593806
#> 13250 1593819
#> 13251 1593820
#> 13252 1593821
#> 13253 1593822
#> 13254 1593823
#> 13255 1593824
#> 13256 1593825
#> 13257 1593826
#> 13258 1593827
#> 13259 1593828
#> 13260 1593829
#> 13261 1593830
#> 13262 1593831
#> 13263 1593832
#> 13264 1593833
#> 13265 1593834
#> 13266 1594084
#> 13267 1594306
#> 13268 1594754
#> 13269 1594759
#> 13270 1594769
#> 13271 1594820
#> 13272 1595375
#> 13273 1595377
#> 13274 1595393
#> 13275 1595394
#> 13276 1595395
#> 13277 1595396
#> 13278 1595397
#> 13279 1595398
#> 13280 1595399
#> 13281 1595510
#> 13282 1595517
#> 13283 1596037
#> 13284 1596038
#> 13285 1596046
#> 13286 1596080
#> 13287 1596510
#> 13288 1596511
#> 13289 1596512
#> 13290 1596513
#> 13291 1596514
#> 13292 1596515
#> 13293 1596516
#> 13294 1596517
#> 13295 1596518
#> 13296 1596519
#> 13297 1596520
#> 13298 1596521
#> 13299 1596522
#> 13300 1596523
#> 13301 1596524
#> 13302 1596525
#> 13303 1596527
#> 13304 1596528
#> 13305 1596529
#> 13306 1596530
#> 13307 1596531
#> 13308 1596532
#> 13309 1596533
#> 13310 1596630
#> 13311 1597179
#> 13312 1597753
#> 13313 1597754
#> 13314 1597755
#> 13315 1597756
#> 13316 1597758
#> 13317 1597759
#> 13318 1597760
#> 13319 1597761
#> 13320 1597762
#> 13321 1597763
#> 13322 1597764
#> 13323 1597765
#> 13324 1597766
#> 13325 1597767
#> 13326 1597768
#> 13327 1597769
#> 13328 1597770
#> 13329 1597930
#> 13330 1597933
#> 13331 1597974
#> 13332 1597990
#> 13333 1598974
#> 13334 1598975
#> 13335 1598980
#> 13336 1598982
#> 13337 1599128
#> 13338 1600524
#> 13339 1600528
#> 13340 1600531
#> 13341 1600533
#> 13342 1600535
#> 13343 1600546
#> 13344 1600547
#> 13345 1600548
#> 13346 1600549
#> 13347 1600550
#> 13348 1600556
#> 13349 1600557
#> 13350 1600565
#> 13351 1600566
#> 13352 1600567
#> 13353 1600568
#> 13354 1600569
#> 13355 1600570
#> 13356 1600571
#> 13357 1600572
#> 13358 1600573
#> 13359 1600574
#> 13360 1600575
#> 13361 1600576
#> 13362 1600577
#> 13363 1601488
#> 13364 1601493
#> 13365 1601639
#> 13366 1601642
#> 13367 1601643
#> 13368 1601644
#> 13369 1601645
#> 13370 1601646
#> 13371 1601647
#> 13372 1601648
#> 13373 1601649
#> 13374 1602814
#> 13375 1602815
#> 13376 1602816
#> 13377 1602817
#> 13378 1602818
#> 13379 1602819
#> 13380 1602820
#> 13381 1602821
#> 13382 1602822
#> 13383 1602823
#> 13384 1602824
#> 13385 1603320
#> 13386 1603736
#> 13387 1604037
#> 13388 1604224
#> 13389 1604229
#> 13390 1604231
#> 13391 1604240
#> 13392 1604277
#> 13393 1604381
#> 13394 1604742
#> 13395 1605076
#> 13396 1605100
#> 13397 1605720
#> 13398 1605721
#> 13399 1606936
#> 13400 1607705
#> 13401 1607707
#> 13402 1607708
#> 13403 1607709
#> 13404 1607728
#> 13405 1607742
#> 13406 1607751
#> 13407 1607752
#> 13408 1608324
#> 13409 1608496
#> 13410 1608513
#> 13411 1608530
#> 13412 1608531
#> 13413 1608544
#> 13414 1608545
#> 13415 1608546
#> 13416 1608550
#> 13417 1608554
#> 13418 1608558
#> 13419 1608562
#> 13420 1608877
#> 13421 1608881
#> 13422 1608888
#> 13423 1608892
#> 13424 1608894
#> 13425 1608898
#> 13426 1608954
#> 13427 1609129
#> 13428 1609130
#> 13429 1609175
#> 13430 1609229
#> 13431 1609779
#> 13432 1610065
#> 13433 1610070
#> 13434 1610074
#> 13435 1610136
#> 13436 1610228
#> 13437 1610229
#> 13438 1610230
#> 13439 1610231
#> 13440 1610250
#> 13441 1610365
#> 13442 1610373
#> 13443 1610654
#> 13444 1610891
#> 13445 1611265
#> 13446 1611268
#> 13447 1611269
#> 13448 1611270
#> 13449 1611271
#> 13450 1611272
#> 13451 1611273
#> 13452 1611274
#> 13453 1611275
#> 13454 1611276
#> 13455 1611277
#> 13456 1611522
#> 13457 1611848
#> 13458 1611979
#> 13459 1611994
#> 13460 1611999
#> 13461 1612001
#> 13462 1612035
#> 13463 1612054
#> 13464 1612088
#> 13465 1612329
#> 13466 1612697
#> 13467 1612875
#> 13468 1613072
#> 13469 1613392
#> 13470 1613395
#> 13471 1613396
#> 13472 1613398
#> 13473 1613399
#> 13474 1613400
#> 13475 1613401
#> 13476 1613402
#> 13477 1613403
#> 13478 1613404
#> 13479 1613405
#> 13480 1613406
#> 13481 1613407
#> 13482 1613408
#> 13483 1613409
#> 13484 1613410
#> 13485 1613411
#> 13486 1613412
#> 13487 1613413
#> 13488 1613414
#> 13489 1613415
#> 13490 1613416
#> 13491 1613417
#> 13492 1613418
#> 13493 1613419
#> 13494 1613420
#> 13495 1613421
#> 13496 1613422
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#> 13500 1613454
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#> 13502 1613456
#> 13503 1613460
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#> 13509 1614561
#> 13510 1614566
#> 13511 1614573
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#> 13513 1614778
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#> 13515 1614780
#> 13516 1615814
#> 13517 1615872
#> 13518 1615886
#> 13519 1616251
#> 13520 1616268
#> 13521 1616271
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#> 13524 1616541
#> 13525 1616542
#> 13526 1616746
#> 13527 1617181
#> 13528 1617607
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#> 13530 1617686
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#> 13535 1619616
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#> 13539 1620067
#> 13540 1621185
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#> 13543 1621404
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#> 13553 1622954
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#> 13555 1622984
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#> 13576 1624076
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#> 13578 1624078
#> 13579 1624079
#> 13580 1624080
#> 13581 1624083
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#> 13583 1624085
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#> 13586 1624088
#> 13587 1624089
#> 13588 1624090
#> 13589 1624091
#> 13590 1624092
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#> 13592 1624108
#> 13593 1624143
#> 13594 1624627
#> 13595 1624729
#> 13596 1624730
#> 13597 1624731
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#> 13599 1624733
#> 13600 1625019
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#> 13602 1625194
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#> 13604 1625198
#> 13605 1625199
#> 13606 1625200
#> 13607 1625201
#> 13608 1625202
#> 13609 1625203
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#> 13611 1625205
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#> 13619 1625213
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#> 13621 1625215
#> 13622 1625216
#> 13623 1625430
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#> 13626 1627187
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#> 13628 1627857
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#> 13641 1628529
#> 13642 1628530
#> 13643 1628681
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#> 13645 1628690
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#> 13648 1628701
#> 13649 1628702
#> 13650 1628703
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#> 13660 1628921
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#> 13663 1628924
#> 13664 1628925
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#> 13669 1630156
#> 13670 1630230
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#> 13678 1630467
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#> 13680 1630670
#> 13681 1631064
#> 13682 1631595
#> 13683 1632122
#> 13684 1632183
#> 13685 1632483
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#> 13687 1633545
#> 13688 1633801
#> 13689 1633802
#> 13690 1633803
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#> 13693 1633826
#> 13694 1634209
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#> 13696 1634240
#> 13697 1634319
#> 13698 1634320
#> 13699 1634321
#> 13700 1634323
#> 13701 1635266
#> 13702 1635269
#> 13703 1635333
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#> 13705 1635336
#> 13706 1636143
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#> 13708 1637287
#> 13709 1637288
#> 13710 1637289
#> 13711 1637290
#> 13712 1637291
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#> 13714 1637293
#> 13715 1637294
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#> 13718 1637297
#> 13719 1637298
#> 13720 1637299
#> 13721 1637300
#> 13722 1637301
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#> 13724 1637303
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#> 13726 1637305
#> 13727 1637306
#> 13728 1637307
#> 13729 1637308
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#> 13731 1637310
#> 13732 1637311
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#> 13737 1637316
#> 13738 1637317
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#> 13747 1637327
#> 13748 1637328
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#> 13759 1637347
#> 13760 1637348
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#> 13762 1637350
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#> 13765 1637353
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#> 13767 1637355
#> 13768 1637514
#> 13769 1637518
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#> 13773 1637522
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#> 13775 1637524
#> 13776 1637525
#> 13777 1637528
#> 13778 1637529
#> 13779 1637530
#> 13780 1637531
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#> 13782 1637534
#> 13783 1637578
#> 13784 1637656
#> 13785 1637805
#> 13786 1637824
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#> 13788 1638892
#> 13789 1639198
#> 13790 1639267
#> 13791 1639268
#> 13792 1639270
#> 13793 1639271
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#> 13795 1639273
#> 13796 1639274
#> 13797 1639275
#> 13798 1639276
#> 13799 1639361
#> 13800 1639362
#> 13801 1639363
#> 13802 1639383
#> 13803 1639498
#> 13804 1639845
#> 13805 1639972
#> 13806 1646179
#> 13807 1646183
#> 13808 1646345
#> 13809 1646361
#> 13810 1646362
#> 13811 1646363
#> 13812 1646364
#> 13813 1646365
#> 13814 1646366
#> 13815 1646370
#> 13816 1646371
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#> 13818 1646373
#> 13819 1646374
#> 13820 1646375
#> 13821 1646376
#> 13822 1646377
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#> 13824 1646379
#> 13825 1646380
#> 13826 1646381
#> 13827 1646382
#> 13828 1647423
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#> 13830 1647706
#> 13831 1647710
#> 13832 1647714
#> 13833 1647718
#> 13834 1647722
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#> 13836 1647748
#> 13837 1647749
#> 13838 1647750
#> 13839 1647751
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#> 13841 1647753
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#> 13844 1647756
#> 13845 1647775
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#> 13851 1647804
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#> 13859 1647968
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#> 13863 1648104
#> 13864 1648909
#> 13865 1649313
#> 13866 1649323
#> 13867 1649330
#> 13868 1649335
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#> 13870 1650131
#> 13871 1650132
#> 13872 1650133
#> 13873 1650617
#> 13874 1650662
#> 13875 1650663
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#> 13877 1650862
#> 13878 1650863
#> 13879 1651056
#> 13880 1651161
#> 13881 1651255
#> 13882 1651256
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#> 13884 1651258
#> 13885 1651551
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#> 13887 1651565
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#> 13889 1651567
#> 13890 1651568
#> 13891 1651569
#> 13892 1651570
#> 13893 1652069
#> 13894 1652074
#> 13895 1652718
#> 13896 1653099
#> 13897 1653107
#> 13898 1653110
#> 13899 1653147
#> 13900 1653179
#> 13901 1653188
#> 13902 1653192
#> 13903 1653197
#> 13904 1653664
#> 13905 1653665
#> 13906 1653667
#> 13907 1653668
#> 13908 1653694
#> 13909 1653695
#> 13910 1653696
#> 13911 1653700
#> 13912 1653704
#> 13913 1653705
#> 13914 1653709
#> 13915 1653713
#> 13916 1653715
#> 13917 1653716
#> 13918 1653721
#> 13919 1653911
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#> 13921 1653914
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#> 13923 1653919
#> 13924 1653935
#> 13925 1653936
#> 13926 1654056
#> 13927 1654070
#> 13928 1654071
#> 13929 1654143
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#> 13932 1655027
#> 13933 1655302
#> 13934 1655401
#> 13935 1655443
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#> 13937 1655700
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#> 13939 1655907
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#> 13941 1656507
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#> 13944 1656992
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#> 13948 1657906
#> 13949 1658389
#> 13950 1658408
#> 13951 1658425
#> 13952 1658670
#> 13953 1658671
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#> 13955 1658673
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#> 13958 1658676
#> 13959 1658677
#> 13960 1658678
#> 13961 1658679
#> 13962 1658680
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#> 13964 1658682
#> 13965 1658683
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#> 13967 1658685
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#> 13971 1658689
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#> 13973 1658916
#> 13974 1658919
#> 13975 1658920
#> 13976 1659073
#> 13977 1659074
#> 13978 1659075
#> 13979 1659212
#> 13980 1659217
#> 13981 1659245
#> 13982 1659646
#> 13983 1659657
#> 13984 1659685
#> 13985 1659842
#> 13986 1659843
#> 13987 1659844
#> 13988 1659845
#> 13989 1659846
#> 13990 1659997
#> 13991 1659998
#> 13992 1659999
#> 13993 1660000
#> 13994 1660001
#> 13995 1660002
#> 13996 1660004
#> 13997 1660005
#> 13998 1660006
#> 13999 1660007
#> 14000 1660008
#> 14001 1660022
#> 14002 1660023
#> 14003 1660024
#> 14004 1660025
#> 14005 1660026
#> 14006 1660027
#> 14007 1660028
#> 14008 1660029
#> 14009 1660030
#> 14010 1660031
#> 14011 1660032
#> 14012 1660033
#> 14013 1660101
#> 14014 1660102
#> 14015 1660123
#> 14016 1660124
#> 14017 1660127
#> 14018 1660128
#> 14019 1660129
#> 14020 1660198
#> 14021 1660199
#> 14022 1660348
#> 14023 1660613
#> 14024 1660615
#> 14025 1660910
#> 14026 1660911
#> 14027 1660912
#> 14028 1660976
#> 14029 1660977
#> 14030 1660978
#> 14031 1660980
#> 14032 1660981
#> 14033 1660982
#> 14034 1660983
#> 14035 1660984
#> 14036 1661120
#> 14037 1661121
#> 14038 1661736
#> 14039 1661953
#> 14040 1662197
#> 14041 1662198
#> 14042 1662203
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#> 14044 1662206
#> 14045 1662207
#> 14046 1662208
#> 14047 1662209
#> 14048 1662213
#> 14049 1662258
#> 14050 1662259
#> 14051 1662260
#> 14052 1662261
#> 14053 1662843
#> 14054 1663469
#> 14055 1663477
#> 14056 1663770
#> 14057 1663861
#> 14058 1664326
#> 14059 1664327
#> 14060 1664371
#> 14061 1664609
#> 14062 1664650
#> 14063 1664700
#> 14064 1664837
#> 14065 1664838
#> 14066 1664839
#> 14067 1664846
#> 14068 1664847
#> 14069 1664848
#> 14070 1664849
#> 14071 1664850
#> 14072 1664851
#> 14073 1664852
#> 14074 1664853
#> 14075 1664854
#> 14076 1664855
#> 14077 1664856
#> 14078 1664857
#> 14079 1664858
#> 14080 1664859
#> 14081 1664860
#> 14082 1664861
#> 14083 1664862
#> 14084 1664863
#> 14085 1664864
#> 14086 1664865
#> 14087 1664866
#> 14088 1664867
#> 14089 1664868
#> 14090 1664869
#> 14091 1664870
#> 14092 1664871
#> 14093 1664872
#> 14094 1664873
#> 14095 1664874
#> 14096 1664875
#> 14097 1664876
#> 14098 1664877
#> 14099 1664878
#> 14100 1664879
#> 14101 1664880
#> 14102 1664881
#> 14103 1664882
#> 14104 1664883
#> 14105 1664884
#> 14106 1664885
#> 14107 1664886
#> 14108 1664887
#> 14109 1664888
#> 14110 1664889
#> 14111 1664890
#> 14112 1664891
#> 14113 1664892
#> 14114 1664893
#> 14115 1664894
#> 14116 1664895
#> 14117 1664896
#> 14118 1664897
#> 14119 1664898
#> 14120 1664899
#> 14121 1664900
#> 14122 1664901
#> 14123 1664902
#> 14124 1664903
#> 14125 1664904
#> 14126 1665003
#> 14127 1666165
#> 14128 1666173
#> 14129 1666196
#> 14130 1666470
#> 14131 1666471
#> 14132 1666472
#> 14133 1666473
#> 14134 1666474
#> 14135 1666475
#> 14136 1666485
#> 14137 1666487
#> 14138 1666488
#> 14139 1666492
#> 14140 1666494
#> 14141 1666497
#> 14142 1666498
#> 14143 1666499
#> 14144 1666500
#> 14145 1666501
#> 14146 1666502
#> 14147 1666503
#> 14148 1666504
#> 14149 1666505
#> 14150 1666506
#> 14151 1666507
#> 14152 1666508
#> 14153 1666509
#> 14154 1666510
#> 14155 1666511
#> 14156 1666512
#> 14157 1666513
#> 14158 1666514
#> 14159 1666515
#> 14160 1666516
#> 14161 1666517
#> 14162 1666518
#> 14163 1666519
#> 14164 1666520
#> 14165 1666521
#> 14166 1666522
#> 14167 1666523
#> 14168 1666524
#> 14169 1666525
#> 14170 1666551
#> 14171 1666557
#> 14172 1666930
#> 14173 1666931
#> 14174 1666932
#> 14175 1666933
#> 14176 1666934
#> 14177 1666935
#> 14178 1666936
#> 14179 1667119
#> 14180 1667121
#> 14181 1667122
#> 14182 1667123
#> 14183 1667124
#> 14184 1667125
#> 14185 1667126
#> 14186 1667127
#> 14187 1667128
#> 14188 1667129
#> 14189 1667130
#> 14190 1667223
#> 14191 1667249
#> 14192 1667426
#> 14193 1667734
#> 14194 1667737
#> 14195 1667740
#> 14196 1667741
#> 14197 1667742
#> 14198 1667743
#> 14199 1667744
#> 14200 1668272
#> 14201 1668527
#> 14202 1668619
#> 14203 1668620
#> 14204 1668621
#> 14205 1668622
#> 14206 1668623
#> 14207 1668624
#> 14208 1668625
#> 14209 1668626
#> 14210 1668627
#> 14211 1669115
#> 14212 1669116
#> 14213 1669121
#> 14214 1669122
#> 14215 1669123
#> 14216 1669124
#> 14217 1669125
#> 14218 1669126
#> 14219 1669127
#> 14220 1669128
#> 14221 1669130
#> 14222 1669244
#> 14223 1669245
#> 14224 1669246
#> 14225 1673180
#> 14226 1673383
#> 14227 1674014
#> 14228 1674266
#> 14229 1674366
#> 14230 1675243
#> 14231 1675244
#> 14232 1675245
#> 14233 1675604
#> 14234 1676415
#> 14235 1677358
#> 14236 1677359
#> 14237 1677360
#> 14238 1677361
#> 14239 1677362
#> 14240 1677363
#> 14241 1677364
#> 14242 1677365
#> 14243 1677366
#> 14244 1677367
#> 14245 1677368
#> 14246 1677369
#> 14247 1677370
#> 14248 1677371
#> 14249 1677372
#> 14250 1677426
#> 14251 1677448
#> 14252 1677449
#> 14253 1677450
#> 14254 1677451
#> 14255 1677452
#> 14256 1677453
#> 14257 1677454
#> 14258 1677455
#> 14259 1677456
#> 14260 1677457
#> 14261 1677458
#> 14262 1677459
#> 14263 1677460
#> 14264 1677461
#> 14265 1677462
#> 14266 1677463
#> 14267 1677464
#> 14268 1677465
#> 14269 1677494
#> 14270 1677495
#> 14271 1677496
#> 14272 1677497
#> 14273 1677498
#> 14274 1677499
#> 14275 1677500
#> 14276 1677501
#> 14277 1677502
#> 14278 1677503
#> 14279 1677504
#> 14280 1677505
#> 14281 1677506
#> 14282 1677509
#> 14283 1677518
#> 14284 1677519
#> 14285 1677520
#> 14286 1677522
#> 14287 1677783
#> 14288 1677979
#> 14289 1677981
#> 14290 1678666
#> 14291 1679880
#> 14292 1679884
#> 14293 1679885
#> 14294 1680004
#> 14295 1680076
#> 14296 1680924
#> 14297 1681125
#> 14298 1681126
#> 14299 1681127
#> 14300 1681128
#> 14301 1682634
#> 14302 1682724
#> 14303 1682727
#> 14304 1682728
#> 14305 1682729
#> 14306 1682790
#> 14307 1682793
#> 14308 1682794
#> 14309 1682795
#> 14310 1682798
#> 14311 1682831
#> 14312 1682910
#> 14313 1682911
#> 14314 1682912
#> 14315 1682913
#> 14316 1682914
#> 14317 1682915
#> 14318 1682916
#> 14319 1682917
#> 14320 1682918
#> 14321 1682919
#> 14322 1682922
#> 14323 1683019
#> 14324 1683020
#> 14325 1683021
#> 14326 1683022
#> 14327 1683040
#> 14328 1683108
#> 14329 1683176
#> 14330 1683177
#> 14331 1683179
#> 14332 1683180
#> 14333 1683183
#> 14334 1683185
#> 14335 1683186
#> 14336 1683189
#> 14337 1683190
#> 14338 1683193
#> 14339 1683196
#> 14340 1683197
#> 14341 1683443
#> 14342 1683444
#> 14343 1683445
#> 14344 1683446
#> 14345 1683447
#> 14346 1683448
#> 14347 1683449
#> 14348 1683450
#> 14349 1683451
#> 14350 1683452
#> 14351 1683453
#> 14352 1683454
#> 14353 1683455
#> 14354 1683456
#> 14355 1683457
#> 14356 1684497
#> 14357 1684592
#> 14358 1686066
#> 14359 1686069
#> 14360 1686070
#> 14361 1686598
#> 14362 1686601
#> 14363 1686691
#> 14364 1688236
#> 14365 1688237
#> 14366 1689067
#> 14367 1689072
#> 14368 1689073
#> 14369 1689074
#> 14370 1689075
#> 14371 1689076
#> 14372 1689077
#> 14373 1689078
#> 14374 1689079
#> 14375 1689080
#> 14376 1689081
#> 14377 1689082
#> 14378 1689083
#> 14379 1689084
#> 14380 1689085
#> 14381 1689086
#> 14382 1689091
#> 14383 1689092
#> 14384 1689093
#> 14385 1689094
#> 14386 1689095
#> 14387 1689096
#> 14388 1689097
#> 14389 1689098
#> 14390 1689107
#> 14391 1689778
#> 14392 1689796
#> 14393 1689800
#> 14394 1690589
#> 14395 1690591
#> 14396 1690602
#> 14397 1690603
#> 14398 1690604
#> 14399 1690605
#> 14400 1690607
#> 14401 1690608
#> 14402 1690609
#> 14403 1690610
#> 14404 1690611
#> 14405 1690612
#> 14406 1690613
#> 14407 1690618
#> 14408 1690801
#> 14409 1691237
#> 14410 1691240
#> 14411 1691244
#> 14412 1691248
#> 14413 1691252
#> 14414 1691257
#> 14415 1691261
#> 14416 1691265
#> 14417 1691553
#> 14418 1692249
#> 14419 1692469
#> 14420 1693359
#> 14421 1693647
#> 14422 1693845
#> 14423 1693848
#> 14424 1693983
#> 14425 1694031
#> 14426 1694032
#> 14427 1694033
#> 14428 1694034
#> 14429 1694035
#> 14430 1694036
#> 14431 1694039
#> 14432 1694124
#> 14433 1694242
#> 14434 1694244
#> 14435 1694245
#> 14436 1694246
#> 14437 1694247
#> 14438 1694248
#> 14439 1694249
#> 14440 1694250
#> 14441 1694251
#> 14442 1694252
#> 14443 1694253
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#> 14445 1694255
#> 14446 1694256
#> 14447 1694257
#> 14448 1694258
#> 14449 1694259
#> 14450 1694260
#> 14451 1694261
#> 14452 1694262
#> 14453 1694263
#> 14454 1694264
#> 14455 1694265
#> 14456 1694266
#> 14457 1694268
#> 14458 1694269
#> 14459 1694300
#> 14460 1694343
#> 14461 1694905
#> 14462 1694945
#> 14463 1695017
#> 14464 1695083
#> 14465 1695300
#> 14466 1695397
#> 14467 1695602
#> 14468 1696476
#> 14469 1696592
#> 14470 1696720
#> 14471 1697174
#> 14472 1697876
#> 14473 1698639
#> 14474 1699009
#> 14475 1699011
#> 14476 1699045
#> 14477 1699052
#> 14478 1699053
#> 14479 1699178
#> 14480 1699179
#> 14481 1699286
#> 14482 1699496
#> 14483 1700000
#> 14484 1700145
#> 14485 1700146
#> 14486 1700147
#> 14487 1700148
#> 14488 1700149
#> 14489 1700150
#> 14490 1700151
#> 14491 1700152
#> 14492 1700153
#> 14493 1700154
#> 14494 1700155
#> 14495 1700168
#> 14496 1700169
#> 14497 1701037
#> 14498 1701222
#> 14499 1701510
#> 14500 1701938
#> 14501 1701960
#> 14502 1701961
#> 14503 1701988
#> 14504 1701989
#> 14505 1701990
#> 14506 1702586
#> 14507 1702932
#> 14508 1702942
#> 14509 1702952
#> 14510 1702962
#> 14511 1702972
#> 14512 1703215
#> 14513 1703284
#> 14514 1703387
#> 14515 1704305
#> 14516 1704388
#> 14517 1704389
#> 14518 1704390
#> 14519 1704493
#> 14520 1704631
#> 14521 1704654
#> 14522 1704670
#> 14523 1705700
#> 14524 1705711
#> 14525 1706104
#> 14526 1706105
#> 14527 1706109
#> 14528 1706124
#> 14529 1706125
#> 14530 1706126
#> 14531 1706127
#> 14532 1706128
#> 14533 1706137
#> 14534 1706138
#> 14535 1706141
#> 14536 1706475
#> 14537 1707043
#> 14538 1707198
#> 14539 1707203
#> 14540 1707214
#> 14541 1707242
#> 14542 1708502
#> 14543 1708503
#> 14544 1708507
#> 14545 1708939
#> 14546 1709300
#> 14547 1709301
#> 14548 1709302
#> 14549 1709727
#> 14550 1709734
#> 14551 1709735
#> 14552 1709736
#> 14553 1709737
#> 14554 1709738
#> 14555 1709739
#> 14556 1709740
#> 14557 1709741
#> 14558 1709742
#> 14559 1709743
#> 14560 1709744
#> 14561 1709745
#> 14562 1709746
#> 14563 1709747
#> 14564 1709748
#> 14565 1709749
#> 14566 1709750
#> 14567 1709751
#> 14568 1709752
#> 14569 1709753
#> 14570 1709754
#> 14571 1709756
#> 14572 1709759
#> 14573 1709762
#> 14574 1709786
#> 14575 1709787
#> 14576 1709799
#> 14577 1709800
#> 14578 1709837
#> 14579 1709838
#> 14580 1709839
#> 14581 1709840
#> 14582 1709841
#> 14583 1709842
#> 14584 1709843
#> 14585 1709844
#> 14586 1709845
#> 14587 1709846
#> 14588 1709847
#> 14589 1709848
#> 14590 1709849
#> 14591 1709850
#> 14592 1709851
#> 14593 1709852
#> 14594 1709853
#> 14595 1709854
#> 14596 1709855
#> 14597 1710777
#> 14598 1711505
#> 14599 1711798
#> 14600 1711841
#> 14601 1713024
#> 14602 1713144
#> 14603 1713253
#> 14604 1713596
#> 14605 1713720
#> 14606 1714143
#> 14607 1714144
#> 14608 1714145
#> 14609 1714146
#> 14610 1714149
#> 14611 1714150
#> 14612 1714151
#> 14613 1714152
#> 14614 1714153
#> 14615 1714154
#> 14616 1714155
#> 14617 1714156
#> 14618 1714157
#> 14619 1714158
#> 14620 1714166
#> 14621 1714167
#> 14622 1714175
#> 14623 1714176
#> 14624 1714179
#> 14625 1714180
#> 14626 1714183
#> 14627 1714184
#> 14628 1716995
#> 14629 1717030
#> 14630 1717096
#> 14631 1719505
#> 14632 1719506
#> 14633 1719507
#> 14634 1719508
#> 14635 1719509
#> 14636 1719510
#> 14637 1719511
#> 14638 1719512
#> 14639 1719513
#> 14640 1719514
#> 14641 1719515
#> 14642 1719518
#> 14643 1719519
#> 14644 1719520
#> 14645 1719521
#> 14646 1719522
#> 14647 1719523
#> 14648 1719524
#> 14649 1720091
#> 14650 1720117
#> 14651 1720437
#> 14652 1720447
#> 14653 1720448
#> 14654 1720449
#> 14655 1720455
#> 14656 1720560
#> 14657 1720561
#> 14658 1720562
#> 14659 1720563
#> 14660 1720564
#> 14661 1720566
#> 14662 1720567
#> 14663 1720568
#> 14664 1722288
#> 14665 1722290
#> 14666 1722676
#> 14667 1722757
#> 14668 1722758
#> 14669 1722763
#> 14670 1722772
#> 14671 1722773
#> 14672 1722774
#> 14673 1722775
#> 14674 1722776
#> 14675 1722777
#> 14676 1722778
#> 14677 1722779
#> 14678 1722780
#> 14679 1722781
#> 14680 1722782
#> 14681 1722783
#> 14682 1722784
#> 14683 1722785
#> 14684 1722786
#> 14685 1722787
#> 14686 1722796
#> 14687 1722852
#> 14688 1722856
#> 14689 1724512
#> 14690 1724530
#> 14691 1725705
#> 14692 1726325
#> 14693 1726326
#> 14694 1726338
#> 14695 1726342
#> 14696 1726344
#> 14697 1726678
#> 14698 1726679
#> 14699 1726680
#> 14700 1726763
#> 14701 1727016
#> 14702 1727051
#> 14703 1727083
#> 14704 1727087
#> 14705 1727091
#> 14706 1727156
#> 14707 1727298
#> 14708 1728741
#> 14709 1728925
#> 14710 1729231
#> 14711 1729297
#> 14712 1729878
#> 14713 1729886
#> 14714 1729887
#> 14715 1729888
#> 14716 1729889
#> 14717 1729896
#> 14718 1729897
#> 14719 1729900
#> 14720 1729901
#> 14721 1729906
#> 14722 1729907
#> 14723 1729916
#> 14724 1729917
#> 14725 1729918
#> 14726 1729919
#> 14727 1730122
#> 14728 1730126
#> 14729 1730127
#> 14730 1730128
#> 14731 1730129
#> 14732 1730130
#> 14733 1730131
#> 14734 1730132
#> 14735 1730133
#> 14736 1730134
#> 14737 1730135
#> 14738 1730136
#> 14739 1730137
#> 14740 1730269
#> 14741 1730301
#> 14742 1730307
#> 14743 1730315
#> 14744 1730323
#> 14745 1730638
#> 14746 1730657
#> 14747 1730721
#> 14748 1730723
#> 14749 1730724
#> 14750 1731561
#> 14751 1731569
#> 14752 1731571
#> 14753 1731573
#> 14754 1731575
#> 14755 1731576
#> 14756 1731578
#> 14757 1731579
#> 14758 1731580
#> 14759 1731581
#> 14760 1731582
#> 14761 1731583
#> 14762 1731584
#> 14763 1731961
#> 14764 1731994
#> 14765 1732003
#> 14766 1732004
#> 14767 1732005
#> 14768 1732006
#> 14769 1732007
#> 14770 1732008
#> 14771 1732009
#> 14772 1732010
#> 14773 1732011
#> 14774 1732012
#> 14775 1732013
#> 14776 1732014
#> 14777 1732015
#> 14778 1732016
#> 14779 1732017
#> 14780 1732018
#> 14781 1732019
#> 14782 1732020
#> 14783 1732021
#> 14784 1732022
#> 14785 1732023
#> 14786 1732024
#> 14787 1732025
#> 14788 1732160
#> 14789 1732410
#> 14790 1732438
#> 14791 1732442
#> 14792 1732443
#> 14793 1732444
#> 14794 1732445
#> 14795 1732446
#> 14796 1732447
#> 14797 1732448
#> 14798 1732449
#> 14799 1732450
#> 14800 1732451
#> 14801 1732452
#> 14802 1732453
#> 14803 1732454
#> 14804 1732455
#> 14805 1732456
#> 14806 1732457
#> 14807 1732458
#> 14808 1733014
#> 14809 1733015
#> 14810 1733017
#> 14811 1733022
#> 14812 1733025
#> 14813 1733026
#> 14814 1733027
#> 14815 1733028
#> 14816 1733029
#> 14817 1733030
#> 14818 1733031
#> 14819 1733125
#> 14820 1734808
#> 14821 1735275
#> 14822 1735672
#> 14823 1735888
#> 14824 1735977
#> 14825 1736121
#> 14826 1736587
#> 14827 1736625
#> 14828 1736761
#> 14829 1737138
#> 14830 1737578
#> 14831 1737579
#> 14832 1737580
#> 14833 1737581
#> 14834 1737582
#> 14835 1737583
#> 14836 1737584
#> 14837 1737585
#> 14838 1737586
#> 14839 1737587
#> 14840 1737797
#> 14841 1737803
#> 14842 1737805
#> 14843 1737806
#> 14844 1737807
#> 14845 1737808
#> 14846 1737809
#> 14847 1737810
#> 14848 1737811
#> 14849 1737812
#> 14850 1737813
#> 14851 1737814
#> 14852 1737815
#> 14853 1737816
#> 14854 1737828
#> 14855 1737829
#> 14856 1737830
#> 14857 1737831
#> 14858 1737832
#> 14859 1737833
#> 14860 1737841
#> 14861 1737842
#> 14862 1737843
#> 14863 1737902
#> 14864 1737912
#> 14865 1737918
#> 14866 1737921
#> 14867 1737957
#> 14868 1737958
#> 14869 1737959
#> 14870 1737960
#> 14871 1737961
#> 14872 1737962
#> 14873 1737963
#> 14874 1737964
#> 14875 1737965
#> 14876 1737966
#> 14877 1737967
#> 14878 1737968
#> 14879 1737969
#> 14880 1737993
#> 14881 1738823
#> 14882 1738838
#> 14883 1738839
#> 14884 1738840
#> 14885 1738841
#> 14886 1738842
#> 14887 1738843
#> 14888 1738844
#> 14889 1738845
#> 14890 1738846
#> 14891 1738847
#> 14892 1738848
#> 14893 1738849
#> 14894 1738850
#> 14895 1738851
#> 14896 1738852
#> 14897 1738853
#> 14898 1738854
#> 14899 1738855
#> 14900 1738856
#> 14901 1738857
#> 14902 1738858
#> 14903 1738859
#> 14904 1738860
#> 14905 1738861
#> 14906 1738862
#> 14907 1738863
#> 14908 1738864
#> 14909 1738865
#> 14910 1738866
#> 14911 1738867
#> 14912 1738868
#> 14913 1738869
#> 14914 1738870
#> 14915 1738871
#> 14916 1738872
#> 14917 1738873
#> 14918 1739707
#> 14919 1739806
#> 14920 1740503
#> 14921 1740506
#> 14922 1740507
#> 14923 1740508
#> 14924 1740509
#> 14925 1740510
#> 14926 1740511
#> 14927 1740512
#> 14928 1740513
#> 14929 1740514
#> 14930 1740515
#> 14931 1740516
#> 14932 1740517
#> 14933 1740518
#> 14934 1740519
#> 14935 1740520
#> 14936 1740521
#> 14937 1740522
#> 14938 1740588
#> 14939 1741420
#> 14940 1741565
#> 14941 1741570
#> 14942 1741571
#> 14943 1741572
#> 14944 1741573
#> 14945 1741574
#> 14946 1741575
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#> 14948 1741577
#> 14949 1741578
#> 14950 1741579
#> 14951 1741580
#> 14952 1741581
#> 14953 1741582
#> 14954 1741583
#> 14955 1741584
#> 14956 1741585
#> 14957 1741586
#> 14958 1741587
#> 14959 1741588
#> 14960 1741589
#> 14961 1741590
#> 14962 1741591
#> 14963 1741592
#> 14964 1741593
#> 14965 1741594
#> 14966 1741595
#> 14967 1741596
#> 14968 1741915
#> 14969 1741916
#> 14970 1741928
#> 14971 1741933
#> 14972 1741934
#> 14973 1741935
#> 14974 1741945
#> 14975 1741946
#> 14976 1741947
#> 14977 1741948
#> 14978 1741949
#> 14979 1741958
#> 14980 1742334
#> 14981 1742340
#> 14982 1742345
#> 14983 1742348
#> 14984 1742365
#> 14985 1742544
#> 14986 1743182
#> 14987 1743648
#> 14988 1743649
#> 14989 1743650
#> 14990 1748631
#> 14991 1750230
#> 14992 1751131
#> 14993 1751298
#> 14994 1751320
#> 14995 1751493
#> 14996 1752063
#> 14997 1752065
#> 14998 1752067
#> 14999 1752068
#> 15000 1752069
#> 15001 1752070
#> 15002 1752506
#> 15003 1752507
#> 15004 1752512
#> 15005 1752513
#> 15006 1752514
#> 15007 1752519
#> 15008 1752520
#> 15009 1752521
#> 15010 1752522
#> 15011 1752532
#> 15012 1752533
#> 15013 1752628
#> 15014 1753127
#> 15015 1753881
#> 15016 1754633
#> 15017 1755070
#> 15018 1755095
#> 15019 1755570
#> 15020 1755830
#> 15021 1755838
#> 15022 1756038
#> 15023 1756134
#> 15024 1756135
#> 15025 1756547
#> 15026 1756924
#> 15027 1756928
#> 15028 1758691
#> 15029 1758986
#> 15030 1759088
#> 15031 1759488
#> 15032 1759850
#> 15033 1759941
#> 15034 1760127
#> 15035 1760129
#> 15036 1760142
#> 15037 1760143
#> 15038 1760144
#> 15039 1760363
#> 15040 1760374
#> 15041 1760386
#> 15042 1760403
#> 15043 1760406
#> 15044 1760409
#> 15045 1760418
#> 15046 1760429
#> 15047 1761743
#> 15048 1761926
#> 15049 1763138
#> 15050 1764002
#> 15051 1764670
#> 15052 1765861
#> 15053 1765919
#> 15054 1766020
#> 15055 1766104
#> 15056 1766105
#> 15057 1766188
#> 15058 1766192
#> 15059 1766196
#> 15060 1766555
#> 15061 1767166
#> 15062 1767912
#> 15063 1767915
#> 15064 1767916
#> 15065 1767917
#> 15066 1767918
#> 15067 1767919
#> 15068 1767920
#> 15069 1767921
#> 15070 1767922
#> 15071 1767923
#> 15072 1767924
#> 15073 1767925
#> 15074 1767926
#> 15075 1767940
#> 15076 1768122
#> 15077 1768411
#> 15078 1769818
#> 15079 1770908
#> 15080 1770909
#> 15081 1770910
#> 15082 1770911
#> 15083 1770912
#> 15084 1770913
#> 15085 1770914
#> 15086 1770915
#> 15087 1770916
#> 15088 1770917
#> 15089 1770918
#> 15090 1770919
#> 15091 1770922
#> 15092 1770923
#> 15093 1770924
#> 15094 1770925
#> 15095 1770926
#> 15096 1770927
#> 15097 1770928
#> 15098 1770979
#> 15099 1771460
#> 15100 1772961
#> 15101 1773310
#> 15102 1773825
#> 15103 1775101
#> 15104 1775102
#> 15105 1775103
#> 15106 1775105
#> 15107 1775116
#> 15108 1776946
#> 15109 1776979
#> 15110 1776988
#> 15111 1776996
#> 15112 1776997
#> 15113 1776998
#> 15114 1776999
#> 15115 1777000
#> 15116 1777001
#> 15117 1777002
#> 15118 1778187
#> 15119 1778194
#> 15120 1778195
#> 15121 1778196
#> 15122 1778197
#> 15123 1778198
#> 15124 1778199
#> 15125 1778200
#> 15126 1778201
#> 15127 1778202
#> 15128 1778203
#> 15129 1778204
#> 15130 1778205
#> 15131 1778206
#> 15132 1778207
#> 15133 1778208
#> 15134 1778209
#> 15135 1778210
#> 15136 1778211
#> 15137 1778212
#> 15138 1778213
#> 15139 1778214
#> 15140 1778215
#> 15141 1778216
#> 15142 1778217
#> 15143 1778218
#> 15144 1778264
#> 15145 1778267
#> 15146 1778268
#> 15147 1778269
#> 15148 1778270
#> 15149 1778271
#> 15150 1778272
#> 15151 1778273
#> 15152 1778274
#> 15153 1778275
#> 15154 1778276
#> 15155 1778277
#> 15156 1778278
#> 15157 1778279
#> 15158 1778280
#> 15159 1778281
#> 15160 1778282
#> 15161 1778283
#> 15162 1778284
#> 15163 1778285
#> 15164 1778286
#> 15165 1778287
#> 15166 1778288
#> 15167 1778295
#> 15168 1778861
#> 15169 1779278
#> 15170 1779396
#> 15171 1780467
#> 15172 1780705
#> 15173 1781484
#> 15174 1781508
#> 15175 1781785
#> 15176 1781786
#> 15177 1781787
#> 15178 1781788
#> 15179 1781789
#> 15180 1781790
#> 15181 1781791
#> 15182 1781792
#> 15183 1781793
#> 15184 1781912
#> 15185 1782147
#> 15186 1782203
#> 15187 1782524
#> 15188 1783715
#> 15189 1783822
#> 15190 1784415
#> 15191 1784416
#> 15192 1784417
#> 15193 1784418
#> 15194 1784973
#> 15195 1785349
#> 15196 1785395
#> 15197 1785503
#> 15198 1785875
#> 15199 1786122
#> 15200 1786123
#> 15201 1789669
#> 15202 1792930
#> 15203 1807436
#> 15204 1807605
#> 15205 1807868
#> 15206 1808095
#> 15207 1810125
#> 15208 1811504
#> 15209 1811505
#> 15210 1811508
#> 15211 1811509
#> 15212 1811510
#> 15213 1811511
#> 15214 1811513
#> 15215 1811514
#> 15216 1811515
#> 15217 1811516
#> 15218 1811517
#> 15219 1811518
#> 15220 1811519
#> 15221 1811520
#> 15222 1811521
#> 15223 1811523
#> 15224 1811524
#> 15225 1811525
#> 15226 1811526
#> 15227 1811527
#> 15228 1811528
#> 15229 1811529
#> 15230 1811530
#> 15231 1811531
#> 15232 1811532
#> 15233 1811533
#> 15234 1811534
#> 15235 1811535
#> 15236 1811536
#> 15237 1811537
#> 15238 1811538
#> 15239 1811540
#> 15240 1811541
#> 15241 1811542
#> 15242 1811543
#> 15243 1811544
#> 15244 1811545
#> 15245 1811546
#> 15246 1811547
#> 15247 1812574
#> 15248 1812601
#> 15249 1814211
#> 15250 1814214
#> 15251 1814215
#> 15252 1814216
#> 15253 1814229
#> 15254 1814233
#> 15255 1814235
#> 15256 1814237
#> 15257 1814239
#> 15258 1814242
#> 15259 1814243
#> 15260 1814244
#> 15261 1814245
#> 15262 1814285
#> 15263 1814787
#> 15264 1815684
#> 15265 1815685
#> 15266 1815686
#> 15267 1815687
#> 15268 1815688
#> 15269 1815692
#> 15270 1815693
#> 15271 1815694
#> 15272 1815695
#> 15273 1815696
#> 15274 1815697
#> 15275 1815698
#> 15276 1815699
#> 15277 1815700
#> 15278 1815701
#> 15279 1815702
#> 15280 1815705
#> 15281 1815706
#> 15282 1815707
#> 15283 1815708
#> 15284 1815709
#> 15285 1815710
#> 15286 1815711
#> 15287 1815712
#> 15288 1815713
#> 15289 1815714
#> 15290 1815715
#> 15291 1815716
#> 15292 1815717
#> 15293 1815733
#> 15294 1815775
#> 15295 1815776
#> 15296 1815853
#> 15297 1816962
#> 15298 1816968
#> 15299 1817207
#> 15300 1817218
#> 15301 1817227
#> 15302 1817281
#> 15303 1817293
#> 15304 1817885
#> 15305 1818071
#> 15306 1818755
#> 15307 1819563
#> 15308 1819564
#> 15309 1819932
#> 15310 1821635
#> 15311 1821636
#> 15312 1821637
#> 15313 1821645
#> 15314 1821646
#> 15315 1821647
#> 15316 1821657
#> 15317 1821658
#> 15318 1821659
#> 15319 1821660
#> 15320 1821661
#> 15321 1821662
#> 15322 1821663
#> 15323 1821664
#> 15324 1821665
#> 15325 1821666
#> 15326 1821667
#> 15327 1821668
#> 15328 1821669
#> 15329 1821670
#> 15330 1821671
#> 15331 1821672
#> 15332 1821673
#> 15333 1821674
#> 15334 1821675
#> 15335 1821676
#> 15336 1821677
#> 15337 1821678
#> 15338 1821679
#> 15339 1821680
#> 15340 1821681
#> 15341 1821682
#> 15342 1821704
#> 15343 1821945
#> 15344 1821946
#> 15345 1821947
#> 15346 1821948
#> 15347 1821949
#> 15348 1821950
#> 15349 1821951
#> 15350 1822233
#> 15351 1822506
#> 15352 1823046
#> 15353 1824978
#> 15354 1825305
#> 15355 1828134
#> 15356 1828747
#> 15357 1828748
#> 15358 1828749
#> 15359 1828750
#> 15360 1828751
#> 15361 1828758
#> 15362 1828759
#> 15363 1828894
#> 15364 1828939
#> 15365 1829031
#> 15366 1829032
#> 15367 1829033
#> 15368 1829034
#> 15369 1829035
#> 15370 1829036
#> 15371 1829037
#> 15372 1829038
#> 15373 1829698
#> 15374 1829941
#> 15375 1830065
#> 15376 1830066
#> 15377 1830067
#> 15378 1830068
#> 15379 1830069
#> 15380 1830076
#> 15381 1830077
#> 15382 1830078
#> 15383 1830080
#> 15384 1830081
#> 15385 1830082
#> 15386 1830789
#> 15387 1831002
#> 15388 1831106
#> 15389 1831107
#> 15390 1831108
#> 15391 1831109
#> 15392 1831110
#> 15393 1831111
#> 15394 1831113
#> 15395 1831116
#> 15396 1831117
#> 15397 1832106
#> 15398 1832112
#> 15399 1832113
#> 15400 1832114
#> 15401 1832115
#> 15402 1832116
#> 15403 1832117
#> 15404 1832118
#> 15405 1832119
#> 15406 1832120
#> 15407 1832121
#> 15408 1832122
#> 15409 1832123
#> 15410 1832124
#> 15411 1832125
#> 15412 1832126
#> 15413 1832127
#> 15414 1832128
#> 15415 1832129
#> 15416 1832130
#> 15417 1832131
#> 15418 1832132
#> 15419 1832133
#> 15420 1832134
#> 15421 1832135
#> 15422 1832136
#> 15423 1832137
#> 15424 1832138
#> 15425 1832139
#> 15426 1832140
#> 15427 1832141
#> 15428 1832142
#> 15429 1832683
#> 15430 1832749
#> 15431 1832975
#> 15432 1833843
#> 15433 1833847
#> 15434 1833938
#> 15435 1834433
#> 15436 1834434
#> 15437 1834435
#> 15438 1834436
#> 15439 1834437
#> 15440 1834438
#> 15441 1835832
#> 15442 1835833

To aggregate concise bioactivity data from each AID:

result <- get_pug_rest(identifier = "79900", namespace = "aid", domain = "assay", operation = "concise", output = "JSON")
result
#> 
#>  An object of class 'PugRestInstance'
#> 
#>  Request Details:  
#>   - Domain: Assay
#>   - Namespace: AID
#>   - Operation: concise
#>   - Identifier: 79900
#> 
#>  NOTE: Run getter function 'pubChemData(...)' to extract raw data retrieved from PubChem Database. 
#>        See ?pubChemData for details.
pubChemData(result)
#> $Table
#> $Table$Columns
#> $Table$Columns$Column
#>  [1] "AID"                 "SID"                 "CID"                
#>  [4] "Activity Outcome"    "Target Accession"    "Target GeneID"      
#>  [7] "Activity Value [uM]" "Activity Name"       "Assay Name"         
#> [10] "Assay Type"          "PubMed ID"           "RNAi"               
#> 
#> 
#> $Table$Row
#> $Table$Row[[1]]
#> $Table$Row[[1]]$Cell
#>  [1] "79900"                                                                                                       
#>  [2] "103416777"                                                                                                   
#>  [3] "6476829"                                                                                                     
#>  [4] "Active"                                                                                                      
#>  [5] ""                                                                                                            
#>  [6] ""                                                                                                            
#>  [7] "0.162"                                                                                                       
#>  [8] "EC50"                                                                                                        
#>  [9] "Tested for antirhinoviral activity of compound against HRV 25 infected H1HeLa cells; Cytotoxicity at > 10 uM"
#> [10] "Confirmatory"                                                                                                
#> [11] "11858991"                                                                                                    
#> [12] ""

These methods provide an efficient and targeted approach to access and analyze cell line-related data in PubChem, supporting a wide range of research applications in cellular biology, pharmacology, and related fields.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.