RAS: Regional Association Score for Genome-Wide Association Studies

Implements the Regional Association Score (RAS) method for genome-wide association studies (GWAS). For each single nucleotide polymorphism (SNP), RAS quantifies the strength of association within its surrounding genomic region, arranges these regional scores along the chromosome into a signal profile, and locates association regions on that profile with one of two detectors: the original changepoint detector, or a box-scan region detector that also delimits broad plateau-shaped regions. Genotypes can be streamed from a chunked on-disk format through compiled code so that peak memory no longer grows with chromosome size, and the regional weights can be taken from an independent external GWAS (harmonised summary statistics) instead of a within-sample split. The method is described in Jiang and Zhang (2025) <doi:10.1073/pnas.2419721122>.

Version:	1.1.2
Imports:	grDevices, graphics, parallel, segmented, stats, tools, utils
Suggests:	testthat (≥ 3.0.0)
Published:	2026-09-26
DOI:	10.32614/CRAN.package.RAS
Author:	Jiahe Jin [aut], Yiran Jiang [aut], Heping Zhang [aut, cre]
Maintainer:	Heping Zhang <heping.zhang at yale.edu>
BugReports:	https://github.com/hepingzhangyale/RAS/issues
License:	MIT + file LICENSE
URL:	https://github.com/hepingzhangyale/RAS
NeedsCompilation:	yes
Language:	en-GB
Citation:	RAS citation info
Materials:	README, NEWS
CRAN checks:	RAS results

Documentation:

Reference manual:

RAS.html , RAS.pdf

Downloads:

Package source:	RAS_1.1.2.tar.gz
Windows binaries:	r-devel: RAS_1.1.2.zip, r-release: RAS_1.1.2.zip, r-oldrel: RAS_1.1.2.zip
macOS binaries:	r-release (arm64): RAS_1.1.2.tgz, r-oldrel (arm64): RAS_1.1.2.tgz, r-release (x86_64): RAS_1.1.2.tgz, r-oldrel (x86_64): RAS_1.1.2.tgz
Old sources:	RAS archive

Linking:

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