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Internally, adoptr is built around the joint
distribution of a test statistic and the unknown location parameter of
interest given a sample size, i.e. \[
\mathcal{L}\big[(X_i, \theta)\,|\,n_i\big]
\] where \(X_i\) is the
stage-\(i\) test statistic and \(n_i\) the corresponding sample size. The
distribution class for \(X_i\) is
defined by specifying a DataDistribution
object, e.g., a
normal distribution
To completely specify the marginal distribution of \(X_i\), the distribution of \(\theta\) must also be specified. The classical case where \(\theta\) is considered fixed, emerges as special case when a single parameter value has probability mass 1.
The simplest supported prior class are discrete
PointMassPrior
priors. To specify a discrete prior, one
simply specifies the vector of pivot points with positive mass and the
vector of corresponding probability masses. E.g., consider an example
where the point \(\delta = 0.1\) has
probability mass \(0.4\) and the point
\(\delta = 0.25\) has mass \(1 - 0.4 = 0.6\).
For details on the provided methods, see
?DiscretePrior
.
adoptr also supports arbitrary continuous priors with support on compact intervals. For instance, we could consider a prior based on a truncated normal via:
cont_prior <- ContinuousPrior(
pdf = function(x) dnorm(x, mean = 0.3, sd = 0.2),
support = c(-2, 3)
)
For details on the provided methods, see
?ContinuousPrior
.
In practice, the most important operation will be conditioning. This is important to implement type one and type two error rate constraints. Consider, e.g., the case of power. Typically, a power constraint is imposed on a single point in the alternative, e.g. using the constraint
If uncertainty about the true response rate should be incorporated in the design, it makes sense to assume a continuous prior on \(\theta\). In this case, the prior should be conditioned for the power constraint to avoid integrating over the null hypothesis:
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.