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clinfun 1.1.5 (10/19/2023)

• clarified one-sided vs two-sided futility boundary for gsdesign functions

clinfun 1.1.4 (10/12/2023)

• added check for n; since it is for stopping early at least two values should be given
• addressed the warning in the example for calogrank; status had both death and transplant

clinfun 1.1.3 (07/11/2023)

• fixed the bug in ph2simon/twostage.admissible when minimax is also optimal
• ph2simon and toxbdry help have been made more clear

clinfun 1.1.2 (06/19/2023)

• changed all dfloat in fortran to dble
• print method for ph2simon now lists admissible designs

New Functionality

• plot and lines method for roc.curve includes the option for precision-recall curve
• roc.curve returns PPV and NPV which are needed for precision-recall curve

clinfun 1.1.1 (03/06/2023)

• changed class check to use inherits instead of comparing strings

New Functionality

• Added out.ties option to coxphCPE for discrete risk score case

clinfun 1.1.0 (02/22/2022)

New Functionality

• Added added admissible two stage design function
• Added added futilbdry function for sequential futility stopping
• added 1:r sample allocation in gsdesign functions
• Fixed the warnings messages from deltaAUC.f

New Documentation

• Added a NEWS.md file to track changes to the package.
• deposited development version on GitHub
• created {pkgdown} website and github actions for building site

clinfun 1.0.15 (04/13/2018)

• Added new function deltaAUC to test for difference in the area under the ROC curves from nested binary regression models.
• power.ladesign does exact null if number of combinations is small
• Added to help of fedesign, ph2simon and ph2single functions

clinfun 1.0.14 (04/25/2017)

• added init.c to register native routines

clinfun 1.0.13 (11/29/2016)

• permlogrank bug fix - strata option gave an error. Names of elements in survfit.object changed. (strata instead of ntimes.strata and n a vector).

clinfun 1.0.12 (08/03/2016)

• added aucVardiTest to compare growth curves

clinfun 1.0.11 (08/11/2015)

• check for misssing values in jonckheere.test

clinfun 1.0.10 (05/18/2015)

• bug fix for pselect; nlen > 3 should have been nlen > 2

clinfun 1.0.9 (02/24/2015)

• use requireNamespace to remove NOTES on functions using survival pkg

clinfun 1.0.8 (02/19/2015)

• fix name swap in the result of mdrr in v1.0.7

clinfun 1.0.7 (02/19/2015)

• new function mdrr added to calculate minimum detectable difference in response rates for given average response rate and class proportion

clinfun 1.0.6 (06/10/2014)

• On rare occasions jonckheere.test gave a p-value bigger than 1. Sometimes 2min(iPVAL, dPVAL, 1) can be larger than 1. Replace with 2min(iPVAL, dPVAL, 0.5) (Thanks to Drs. Shterev and Owzar of Duke).

clinfun 1.0.5 (04/16/2013)

• Fixed the bound checks

clinfun 1.0.4 (01/22/2013)

• Added the option to calculate continuity corrected sample size in the function gsdesign.binomial.

clinfun 1.0.3 (10/15/2012)

• Fixed two-sided p-value > 1 bug when statistic is exactly its mean.
• Fixed Rd file to address LaTeX warnings.

clinfun 1.0.2 (09/25/2012)

• integer overflow in djonck for the Jonckheere-Terpstra statistic. replace with pdf calculation using Mark van de Wiel convolution.
• Create seperate help for functions permlogrank and jonckheere.test

clinfun 1.0.1 (08/14/2012)

• Fix integer overflow because of n0n1 == 0 in roc.curve and nnnd == 0 in roc.area.test
• In coxphQuantile eliminate times for which survival probability is 0 or 1 from quantile computation.

clinfun 1.0.0 (03/13/2012)

• clinfun number changed to 1.0.0 in preparation for R 2.15.

• toxbdry now does the entire Pocock to O’Brien-Fleming range of boundaries. Added references for the method.
• Fixed linebreak in the help for coxphERR.

clinfun 0.9.9 (01/18/2012)

• Added coxphERR to calculate Heller’s explained relative risk.
• Fixed NaN bug in toxbdry when priority=“alt” is used.

clinfun 0.9.8 (09/13/2011)

• fixed bug in print.gsdesign for binomial case (p1,p2 instead of pC,pE)
• ROC functions now check that there are at least one each of status=0,1

clinfun 0.9.7 (04/27/2011)

• fixed fortran code to address gfortran-4.6 warnings
• added ktau a faster implementation of cor(x, y, method=“k”). not in NAMESPACE. Should be called using clinfun:::ktau

clinfun 0.9.7 (04/25/2011)

• bug fix: roc.area.test integer overflow for large nn*nd.
• use sort function to speed up roc curve and area estimation.

clinfun 0.9.6 (03/24/2011)

• bug fix: roc.area.test gave NaN as the statistic and p-value when the markers are identical. Changed it to 0.

clinfun 0.9.5 (03/09/2011)

• bug fix: gsdesign funtions not returning the sample size / # events.

clinfun 0.9.4 (02/24/2011)

• twostage.inference for umvue, p-value and CI for 2 stage design.

clinfun 0.9.3 (12/06/2010)

• ph2simon was testing whether dim is null for feasible solution. Replaced with nrow == 0 since it is now possible to have 0 rows.

clinfun 0.9.2 (11/05/2010)

• Added functions to compute and plot the empirical ROC curve.

clinfun 0.9.1 (11/03/2010)

• Added functions for the area and permutation tests to compare ROC.
• Checks that min.diff is greater than 0 in pselect.

clinfun 0.9.0 (11/01/2010)

• Added a non-binding futility boundary to gsdesign

clinfun 0.8.10 (04/16/2010)

• variable names for returned data.frame in coxphQuantile
• examples in coxphQuantile & coxphCPE use status==2

clinfun 0.8.9 (04/09/2010)

• check R# clinfun so that coxphCPE works for any # clinfun (see 0.8.9)

clinfun 0.8.8 (04/07/2010)

• Change coxphCPE to reflect the fact that model.matrix.coxph doesn’t have an intercept term.

clinfun 0.8.8 (02/25/2010)

• Added the function or2pcase

clinfun 0.8.7 (11/20/2009)

• Fixed the 0/0 bug in the revised pselect

clinfun 0.8.6 (11/17/2009)

• Changed Venkat’s affiliation to MSKCC.
• Fixed pselect to calculate the selection probability correctly when only one treatment exceeds the min.resp threshold.

clinfun 0.8.5 (07/10/2009)

• Changed the Jonckheere-Terpstra statistic such that large value is indicative of increasing group locations and small for decreasing. Function warns that p-value is based on approximation for tied data.

clinfun 0.8.4 (12/02/2008)

• Added functionality to pselect. It can do unequal sample size for the case of two treatments. min.diff can be specified as a rate instead of number of responses. Output element names changed to be more descriptive.

clinfun 0.8.3 (11/18/2008 & 09/18/2008)

• Fixed the bug CPS.ssize. call inside used fixed alpha, power & r.
• Fixed the bug in the approximate one-sided p-value of Jonckheere test. wrong tail was used.

clinfun 0.8.2 (06/20/2008)

• toxbdry allows the error threshold to prioritize when the sample size is too small to have both satisfied.

clinfun 0.8.1 (06/17/2008)

• Fixed gsdesign to allow for fixed sample designs. Help file fixed.

clinfun 0.8.0 (05/23/2008)

• New # clinfun with one new function power.lehmann.design

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.