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Enrichment strategies play a critical role in modern clinical trial design, especially as precision medicine advances the focus on patient-specific efficacy. Recent developments in enrichment design have introduced biomarker randomness and accounted for the correlation structure between treatment effect and biomarker, resulting in a two-stage threshold enrichment design. We propose novel two-stage enrichment designs capable of handling two or more continuous biomarkers. See Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report.
| Version: | 1.0.1 |
| Depends: | R (≥ 4.2.0) |
| Imports: | tmvtnorm (≥ 1.2), stats (≥ 4.0.0) |
| Published: | 2025-04-15 |
| DOI: | 10.32614/CRAN.package.cobenrich |
| Author: | Jiangtao Gou [aut, cre], Fengqing (Zoe) Zhang [aut] |
| Maintainer: | Jiangtao Gou <gouRpackage at gmail.com> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| CRAN checks: | cobenrich results |
| Reference manual: | cobenrich.pdf |
| Package source: | cobenrich_1.0.1.tar.gz |
| Windows binaries: | r-devel: cobenrich_1.0.1.zip, r-release: cobenrich_1.0.1.zip, r-oldrel: cobenrich_1.0.1.zip |
| macOS binaries: | r-release (arm64): cobenrich_1.0.1.tgz, r-oldrel (arm64): cobenrich_1.0.1.tgz, r-release (x86_64): cobenrich_1.0.1.tgz, r-oldrel (x86_64): cobenrich_1.0.1.tgz |
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