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dotgen: Gene-Set Analysis via Decorrelation by Orthogonal Transformation

Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.

Version: 0.1.1
Depends: R (≥ 3.5.0), mvtnorm
Published: 2024-10-27
DOI: 10.32614/CRAN.package.dotgen
Author: Olga Vsevolozhskaya ORCID iD [aut], Dmitri Zaykin ORCID iD [aut], Xiaoran Tong ORCID iD [aut, cre]
Maintainer: Xiaoran Tong <xt at uky.edu>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
URL: https://github.com/xiaoran831213/dotgen
NeedsCompilation: no
CRAN checks: dotgen results

Documentation:

Reference manual: dotgen.pdf

Downloads:

Package source: dotgen_0.1.1.tar.gz
Windows binaries: r-devel: dotgen_0.1.1.zip, r-release: dotgen_0.1.1.zip, r-oldrel: dotgen_0.1.1.zip
macOS binaries: r-release (arm64): dotgen_0.1.1.tgz, r-oldrel (arm64): dotgen_0.1.1.tgz, r-release (x86_64): dotgen_0.1.1.tgz, r-oldrel (x86_64): dotgen_0.1.1.tgz
Old sources: dotgen archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.