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Dowser

Dowser is part of the Immcantation analysis framework for Adaptive Immune Receptor Repertoire sequencing (AIRR-seq). Dowser provides a set of tools for performing phylogenetic analysis on B cell receptor repertoires. It supports building and visualizing trees using multiple methods, and implements statistical tests for discrete trait analysis of B cell migration, differentiation, and isotype switching.

Dowser has 6 primary functions:

1. Reconstruct clonal germline sequences.
2. Build B cell lineage trees using multiple methods, such as maximum parsimony, maximum likelihood, and IgPhyML.
   
3. Reconstruct intermediate sequences within lineage trees using different methods.
4. Create publication-quality lineage tree plots.
5. Analyze trees to detect ongoing B cell evolution over time.
6. Understand B cell migration and differentiation.

What’s a dowser?

Contact

For help and questions please contact the Immcantation Group or use the issue tracker.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.