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IMPORTANT! Dowser’s source code has moved to https://github.com/immcantation/dowser

To update Git configuration settings use:

   git config user.email "your-gh-user@email.com"
   git config user.name "your-gh-user-name"
   git remote set-url origin git@github.com:immcantation/dowser.git

Dowser

Dowser is part of the Immcantation analysis framework for Adaptive Immune Receptor Repertoire sequencing (AIRR-seq). Dowser provides a set of tools for performing phylogenetic analysis on B cell receptor repertoires. It supports building and visualizing trees using multiple methods, and implements statistical tests for discrete trait analysis of B cell migration, differentiation, and isotype switching.

Dowser has 6 primary functions:

1. Reconstruct clonal germline sequences.
2. Build B cell lineage trees using multiple methods, such as maximum parsimony, maximum likelihood, and IgPhyML.
   
3. Reconstruct intermediate sequences within lineage trees using different methods.
4. Create publication-quality lineage tree plots.
5. Analyze trees to detect ongoing B cell evolution over time.
6. Understand B cell migration and differentiation.

What’s a dowser?

Documentation and tutorials

Full documentation, including tutorials and vignettes: https://dowser.readthedocs.io

Contact

If you need help or have any questions, please contact the Immcantation Group.

If you have discovered a bug or have a feature request, you can open an issue using the issue tracker.

To receive alerts about Immcantation releases, news, events, and tutorials, join the Immcantation News Google Group. Membership settings can be adjusted to change the frequency of email updates.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.