insulin.secretion: Insulin Secretion Rate Deconvolution

Calculates insulin secretion rates from C-peptide values based on the methods described in Van Cauter et al. (1992) <doi:10.2337/diab.41.3.368>. Includes functions to calculate estimated insulin secretion rates using linear or cubic spline interpolation of c-peptide values (see Eaton et al., 1980 <doi:10.1210/jcem-51-3-520> and Polonsky et al., 1986 <doi:10.1172/JCI112308>) and to calculate estimates of input coefficients (volume of distribution, short half life, long half life, and fraction attributed to short half life) as described by Van Cauter. Although the generated coefficients are specific to insulin secretion, the two-compartment secretion model used here is useful for certain applications beyond insulin.

Version:	0.0.1
Imports:	glue, lifecycle, npreg, rlang
Published:	2025-11-05
DOI:	10.32614/CRAN.package.insulin.secretion (may not be active yet)
Author:	Ken Stier [aut, cre, cph]
Maintainer:	Ken Stier <kennethstier99 at gmail.com>
BugReports:	https://github.com/kstier/isr.deconv/issues
License:	GPL (≥ 3)
URL:	https://github.com/kstier/isr.deconv
NeedsCompilation:	no
CRAN checks:	insulin.secretion results

Documentation:

Reference manual:

insulin.secretion.html , insulin.secretion.pdf

Downloads:

Package source:	insulin.secretion_0.0.1.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): insulin.secretion_0.0.1.tgz, r-oldrel (arm64): insulin.secretion_0.0.1.tgz, r-release (x86_64): insulin.secretion_0.0.1.tgz, r-oldrel (x86_64): insulin.secretion_0.0.1.tgz

Linking:

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