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multfisher: Optimal Exact Tests for Multiple Binary Endpoints

Calculates exact hypothesis tests to compare a treatment and a reference group with respect to multiple binary endpoints. The tested null hypothesis is an identical multidimensional distribution of successes and failures in both groups. The alternative hypothesis is a larger success proportion in the treatment group in at least one endpoint. The tests are based on the multivariate permutation distribution of subjects between the two groups. For this permutation distribution, rejection regions are calculated that satisfy one of different possible optimization criteria. In particular, regions with maximal exhaustion of the nominal significance level, maximal power under a specified alternative or maximal number of elements can be found. Optimization is achieved by a branch-and-bound algorithm. By application of the closed testing principle, the global hypothesis tests are extended to multiple testing procedures.

Version: 1.1
Depends: R (≥ 3.0.0)
Imports: stats
Published: 2018-02-23
DOI: 10.32614/CRAN.package.multfisher
Author: Robin Ristl [aut, cre]
Maintainer: Robin Ristl <robin.ristl at meduniwien.ac.at>
License: GPL-3
NeedsCompilation: no
Citation: multfisher citation info
CRAN checks: multfisher results

Documentation:

Reference manual: multfisher.pdf

Downloads:

Package source: multfisher_1.1.tar.gz
Windows binaries: r-devel: multfisher_1.1.zip, r-release: multfisher_1.1.zip, r-oldrel: multfisher_1.1.zip
macOS binaries: r-release (arm64): multfisher_1.1.tgz, r-oldrel (arm64): multfisher_1.1.tgz, r-release (x86_64): multfisher_1.1.tgz, r-oldrel (x86_64): multfisher_1.1.tgz
Old sources: multfisher archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.