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pksensi 1.2.3

• Syntax update (check & install)
• Fix bug (check)
• Fix MCSim installation issue (#9)
• Remove dependent: magrittr, reshape2
• New function: set_rtools40_path()
• Add feature to run simple simulation (generate_infile())

pksensi 1.2.2

• Add more flexible parallel method (solve_mcsim())
• Fix error in previous version

pksensi 1.2.1

• Add mcsim_pkg() to download and run portable MCSim
• Change the site location to https://nanhung.github.io
• Improve coverage

pksensi 1.2.0

• update the route to load example model
• update the default MCSim version to 6.2.0
• Switch the contact mail to d99622005@ntu.edu.tw

pksensi 1.1.7

• Suggested to use Rtools40
• Added parallel method in solve_mcsim()
• Fixed bug in heat_check()
• Added message of display info in heat_check() function
• Improved heat_check() to display the indices based on the setting cut-off

pksensi 1.1.6

• Improved heat_check() to only show influential parameters as default
• Updated check() to return the SI and CI in a list

pksensi 1.1.5

• solve_mcsim(): extend the flexible for the model in subfolder
• Update the vignettes (add deSolve modeling example)

pksensi 1.1.4

• Replace SE to NSE in heat_check()
• Update manual

pksensi 1.1.3

• Update solve_fun() to run deSolve with Pure R code
• set default mxstep = 5000 in mcsim_install()

pksensi 1.1.2

• Add timer in solve_fun()
• Add default MCSim version = '6.1.0' in compile_model()
• Update pksim(): Can customize xlab and ylab
• Update pbtk1cpt model: Add body weight
• Update vignettes
• Fix bug: Create .dll in win10 through compile_model()
• Fix bug: plot() cannot display variable name when using character
• Revise the mcsim_version() for Windows OS

pksensi 1.1.1

Fix Bug:

• Add rtol and atol in solve_mcsim()
• Switch default compiler from Clang to GCC in MacOS
• Fix the mName problem under Windows environment in solve_mcsim()

Update vignette

• Remind to set the mxstep to 5000 in APAP-PBPK example
• Add note to APAP vignette (Set atol and rtol)

Update function

• mcsim_version() can work in MCSim_under_R
• Stop the function when compile error in compile_model()
• Revise the default name of output to “simmc.out” and “setpts.out” in solve_mcsim()

pksensi 1.1.0

Fix Bug:

• Used single time point in solve_mcsim()

Update function:

Installation

• Update the default MCSim version to version = 6.1.0 in install_mcsim()
• Adopt the name of model file (“model.R.exe”) to MCSim_under_R project

Modeling

• Change assignment n to monte_carlo in solve_mcsim()
• Revise the default name of output to “sim.out” and “setpoint.out” in solve_mcsim()
• Add solving message to track time spend in solve_mcsim()
• Add assignment tell = T to automatically combine the output y in decoupling simulation x in solve_fun() and solve_mcsim()

Plot

• Transfer the log-transformed value to natural scale in pksim()
• Revise the discrete time condition to length(times) < 16 in heat_check()

pksensi 1.0.1

New vignette:

• Add “PBTK 1-compartment model”
• Add “Acetaminophen-PBPK model”

New example:

• Update example in solve_mcsim()

New function:

• Add pbtk1cpt_model()
• Add pbpk_apap_model()
• Add function mcsim_version()

NEW dataset:

• Add APAP dataset

Fix Bug:

• Fix the order argument in heat_check()
• Add message in generate_infile()

Update function:

• Remove argument params in solve_fun()
• No need to define infile.name and outfile.name in solve_mcsim()

Change:

• Change function’s name install_mcsim() to mcsim_install()

pksensi 1.0.0

• Initial release in CRAN

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.