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Added NCA parameter estimation to
calc_derived_1cpt(), calc_derived_2cpt() and
calc_derived_3cpt(), if dose and other required information
(e.g. tinf, dur, tau) is
provided.
Added a warning about flip-flop kinetics and their potential
effects on derived half-lives to calc_derived_1cpt(),
calc_derived_2cpt(), and
calc_derived_3cpt().
Added blq_trans() and blq_log_trans()
for assistance with visualization of measurements below a limit of
quantification.
Added a test for valid XML to read_nm().
Small fixes and enhancements to
read_nmtable_single() and
read_nm_multi_table() to ensure that stray text is properly
handled while reading in NONMEM output files.
count_na() now throws a warning if NaN
values are included in the NA count, and indicates how many
of them there are.
Changed the significant digits functionality for 95% confidence
intervals for get_theta(), get_omega() and
get_sigma(), and all functions that apply these.
Replaced gridExtra with
patchwork.
Numerous small fixes.
Removed some unnecessary dependencies.
Added many new unit tests, increasing test coverage considerably.
Fixed another error in sample_uncert() which was
still crashing the function.
Added helper functions count_na(),
dgr_table(), gcv(),
fmt_signif().
Added distribution plotting function
plot_dist().
sample_uncert() which was crashing
the function.Added vignette describing PK curves.
Fixed a systematic error in
calc_sd_1cmt_linear_oral_0_lag(),
calc_ss_1cmt_linear_oral_0_lag(),
calc_sd_2cmt_linear_oral_0_lag() which resulted in
incorrect curves being plotted.
Rewrote plot_scm function to produce tree diagrams
via DiagrammeR.
Fixed a rare bug in get_auc in which measurements
from different individuals could be erroneously mixed.
Amended (or added) read_nm(),
read_nm_all(), read_nmext(),
read_nmcov(), read_nmtables() functions to
allow reading of multiple NONMEM estimation steps.
Clarified documentation for calc_derived().
Now using xml2 to read NONMEM-generated XML
files.
Fixed partial argument match warnings encountered during tests.
Add function for calculting geometric CV.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.