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The reflimR package provides a simple and robust three-step procedure for the estimation of reference intervals from routine laboratory data that may contain an unknown proportion of pathological results. Reference intervals play a crucial role in the medical interpretation and statistical evaluation of laboratory results.
To install the reflimR package, open R and enter the following command in the console:
install.packages("reflimR")This command will download the package from CRAN. Once the installation is complete, load the package into your R session using the following command:
library(reflimR)The package will then be ready for use in your R environment (e.g. in RStudio). To see the documentation of the package with all its help files, please enter
help(package = reflimR)Here is a basic example demonstrating how to use reflimR:
library(reflimR)
x <- c(rnorm(800, 100, 10), rnorm(100, 70, 15), rnorm(100, 125, 15))
reflim(x, targets = qnorm(c(0.025, 0.975), 100, 10))reflimR has been published in: Hoffmann, G., Klawitter, S., Trulson, I., Adler, J., Holdenrieder, S., & Klawonn, F. (2024). A Novel Tool for the Rapid and Transparent Verification of Reference Intervals in Clinical Laboratories. Journal of clinical medicine, 13(15), 4397. https://doi.org/10.3390/jcm13154397
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.