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seqDesign: Simulation and Group Sequential Monitoring of Randomized Two-Stage Treatment Efficacy Trials with Time-to-Event Endpoints

seqDesign is an R package implementing a modification of the preventive vaccine efficacy trial design of Gilbert P. B., Grove D. et al. (2011), A Sequential Phase 2b Trial Design for Evaluating Vaccine Efficacy and Immune Correlates for Multiple HIV Vaccine Regimens, Statistical Communications in Infectious Diseases, 3:1, Article 4.

Check out the following two vignettes, in this order, for a brief introduction to the package: * Instructions for Using seqDesign and Generating the Output PDF Report, and * seqDesign’s Report Template.

The latter includes a report template PDF as well as the underlying code (Latex + R included in an Rnw file).

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.