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Create mixed models with repeated measures using natural cubic splines applied to an observed continuous time variable, as described by Donohue et al. (2023) <doi:10.1002/pst.2285>. Iterate through multiple covariance structure types until one converges. Categorize observed time according to scheduled visits. Perform subgroup analyses.
| Version: | 0.1.0 |
| Imports: | car, cli, dplyr, emmeans, mmrm (≥ 0.3.16), rlang, splines |
| Suggests: | ggplot2, testthat (≥ 3.0.0) |
| Published: | 2025-12-18 |
| DOI: | 10.32614/CRAN.package.splinetrials |
| Author: | Nik Krieger [aut, cre], Daniel Sabanes Bove [ctb], Eli Lilly and Company [cph] |
| Maintainer: | Nik Krieger <nikkrieger at gmail.com> |
| BugReports: | https://github.com/NikKrieger/splinetrials/issues |
| License: | Apache License (≥ 2) |
| URL: | https://github.com/NikKrieger/splinetrials, https://nikkrieger.github.io/splinetrials/ |
| NeedsCompilation: | no |
| Materials: | README, NEWS |
| CRAN checks: | splinetrials results |
| Reference manual: | splinetrials.html , splinetrials.pdf |
| Package source: | splinetrials_0.1.0.tar.gz |
| Windows binaries: | r-devel: splinetrials_0.1.0.zip, r-release: not available, r-oldrel: splinetrials_0.1.0.zip |
| macOS binaries: | r-release (arm64): splinetrials_0.1.0.tgz, r-oldrel (arm64): splinetrials_0.1.0.tgz, r-release (x86_64): splinetrials_0.1.0.tgz, r-oldrel (x86_64): splinetrials_0.1.0.tgz |
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These binaries (installable software) and packages are in development.
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