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ssutil

ssutil is an R package providing a suite of tools for sample size estimation and power simulation in a variety of clinical trial designs. It includes methods for binomial, normal, and negative binomial endpoints, as well as support for equivalence and non-inferiority testing scenarios. It also includes functionality for power and sample size calculation for selecting the best group using the indifferent-zone approach for normal and binomial outcomes.

Features

• Empirical power simulation for:
  • Binomial, normal, and negative binomial endpoints
  • Equivalence and non-inferiority designs
  • Best group selection using the indifferent-zone approach for normal and binomial outcomes
• Sample size utilities for various design types

Installation

# Install from GitHub (requires remotes or devtools)
remotes::install_github("johnaponte/ssutil")

Vignettes

Learn how to use ssutil through these worked examples:

• Selection of the best group using indifferent zone approach for binomial outcomes

• Selection of the best group using indifferent zone approach for normal outcomes

• Equivalence Trials

• Negative Binomial Models

• Non-Inferiority Testing

• Single Rate Power

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.