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Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses
Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <DOI:10.1111/1467-9876.00244> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.